Abstract: Analyte collection and testing systems and methods, and more particularly to testing systems and methods that achieve significant improvements in the detection of fluorescence signals in the reader by modulating the applied optical excitation. Also described herein are optical detection apparatuses and methods for removable photonic chips that do not require translation for calibration when coupling the photonics chip with the sensing system. Also described herein are methods and apparatuses for accurately calibrating a dilution factor when reading from a photonics chip.

Abstract: A quality control method for a diisononyl phthalate includes a measuring step of irradiating the diisononyl phthalate with a laser to measure a Raman spectrum; and an acceptance or rejection decision step of determining an acceptance or a rejection of a quality of the diisononyl phthalate on the basis of a high and low intensity relationship between an intensity of a first spectral peak, which is ascribed to a vibration of molecular chains in a straight chain hydrocarbon, and an intensity of a second spectral peak, which is ascribed to a vibration of isopropyl groups, in the measured Raman spectrum.

Abstract: A method for use in measuring one or more characteristics of patterned structures, the method including providing measured data comprising data indicative of at least one Raman spectrum obtained from a patterned structure under measurements using at least one selected optical measurement scheme each with a predetermined configuration of at least one of illuminating and collected light conditions corresponding to the one or more characteristics to be measured, processing the measured data, and determining, for each of the at least one Raman spectrum, a distribution of Raman-contribution efficiency (RCE) within at least a part of the structure under measurements, being dependent on characteristics of the structure and the predetermined configuration of the at least one of illuminating and collected light conditions in the respective optical measurement scheme, and analyzing the distribution of Raman-contribution efficiency and determining the one or more characteristics of the structure.

Abstract: A sampling device is provided, including: a syringe barrel having an opening and a holding portion; a plunger body having a protruding wall and disposed in the syringe barrel through the opening, where the protruding wall has a first recessed portion; a spring disposed around the plunger body; and a fastening assembly having an engaging structure for engaging the fastening assembly with the holding portion, a groove rail for receiving the protruding wall of the plunger body and a fastening portion for limiting displacement of the plunger body. A semi-automatic sample feeding device is further provided and includes the sampling device and a flow control device, and a test paper detection system is also provided and includes the semi-automatic sample feeding device and a test paper device. The test paper detection system is able to stably introduce samples, suitable for large-volume samples, which meets the needs of point-of-care applications.

Abstract: According to various embodiments of the present invention, an optical capture system is provided. In one embodiment, a micro-scale optical capturing system is provided with low divergence (approximately 1°) of the incident light and low acceptance angle (<8°) of the captured light. According to embodiments, a micro-scale optical capturing system is provided with a large number of collimated high-power white LEDs as light sources, between 60 and 100 units, for example, and may be positioned at distances of about 650 mm from the sample. In one embodiment, a digital camera using 50 mm focal objective with a 25 mm length extension tube captures images of the sample. This provides a working distance of approximately 100 mm and at the same time maintains ×0.5 magnification for microscale captures, with an image size of 4×4 microns per pixel.

Abstract: In order to reduce inspection tact time in centralized management of a plurality of inspection lines, the system includes: a plurality of inspection lines 4 each having a visual appearance inspection device 3; a first database 5A for storing a captured image captured by each of the visual appearance inspection device 3; and a centralized control device 6 connected to each of the visual appearance inspection devices 3 and the first database 5A, having a display unit 32 that displays an inspection image of an inspection object 7, and enabling visual inspection of the inspection object 7 conveyed on each of the inspection lines 4 in a centralized manner; wherein, while one of the inspection lines 4 is inspected by using the centralized control device 6, the visual appearance inspection devices 3 of the other inspection lines 4 pre-captures the inspection object 7 conveyed on the inspection line 4 under predetermined capturing conditions and stores the pre-captured image in the first database 5A, and wherein the

Abstract: A computer-implemented method comprising: controlling input of data quantifying damage received by a compressor of a gas turbine engine into a first machine learning algorithm; receiving data quantifying a first operating parameter of the compressor as an output of the first machine learning algorithm; and determining operability of the compressor by comparing the received data quantifying the first operating parameter of the compressor with a threshold.

Abstract: Embodiments include a method, comprising: receiving measured radiation obtained from a radiation detector that received radiation through an object; simulating the measured radiation obtained from the radiation detector that received radiation through the object; generating an offset based on the measured radiation and the simulated measured radiation; estimating scatter radiation based on the offset; and estimating primary radiation based on the estimated scatter radiation.

Abstract: Determining a property of a layer of an integrated circuit (IC), the layer being formed over an underlayer, is implemented by performing the steps of: irradiating the IC to thereby eject electrons from the IC; collecting electrons emitted from the IC and determining the kinetic energy of the emitted electrons to thereby calculate emission intensity of electrons emitted from the layer and electrons emitted from the underlayer calculating a ratio of the emission intensity of electrons emitted from the layer and electrons emitted from the underlayer; and using the ratio to determine material composition or thickness of the layer. The steps of irradiating IC and collecting electrons may be performed using x-ray photoelectron spectroscopy (XPS) or x-ray fluorescence spectroscopy (XRF).

Abstract: A substrate 1 includes a color center excited by excitation light, and at least a pair of reflection members 21a, 21b are arranged with gaps from the substrate 1. The substrate 1 causes the excitation light entering the substrate 1 to exit through its surfaces without reflection, and the reflection members 21a, 21b cause the exited excitation light to reflect at the reflection surface 21-1 or 21-2 and enter the substrate 1, and cause the excitation light to repeatedly enter and exit the substrate 1 and thereby pass through the substrate 1 only a predetermined number of times. Here, the irradiating device 4 emits the excitation light such that the excitation light is incident to the reflection surface 21-1 or 21-2 with an angle perpendicular to one axis among two axes of the reflection surface 21-1 or 21-2 and with a predetermined slant angle from the other axis.

Abstract: A moisture detection system may include a baseboard including a first electrode and a second electrode; and a moisture detector configured to detect whether a circuit is closed by a conductive liquid making simultaneous contact with the first electrode and the second electrode.

Abstract: A gas detection device and a process monitor an area for a combustible target gas. A heating segment of a detector (10) is heated when electrical current flows therethrough. A heating segment of a compensator (1) is heated when electrical current flows therethrough. An electrical voltage is applied to both the detector and the compensator. The heating of the detector (10) causes a combustible target gas to be oxidized in an interior of the gas detection device. A detection variable, which depends on the temperature (Temp_10) of the detector, and a detection variable, which depends on the temperature (Temp_11) of the compensator, are measured. A presence and/or a concentration of a target gas are determined as a function of the detection variables. A quality parameter is measured and increases as the detection variable depending on the detector temperature increases and as the detection variable depending on the compensator temperature decreases.

Abstract: The subject of the present invention is the sensor for the impedance measurements of the biological or chemical factor sample in the potentiostat system comprising the reference electrode RE and counting electrode CE with the electric contacts leading to the edge of the sensor in the form of the edge connector characterised in that it contains n working electrodes WEn, wherein n>2 and preferably n is in the range 2 to 256, and the reference electrode RE is common for all working electrodes WEn and the fragment thereof present by the working electrode WEn forms the measuring segment RE-CE-WEn. The subject of the invention is also the detection method of the chemical or biological factor in the sample using such a sensor.

Abstract: In a sensor element for a limiting-current type gas sensor measuring concentration of NOx in a measurement gas, an inner pump electrode located to face a first internal space communicating with a gas inlet through which the measurement gas is introduced from an external space under predetermined diffusion resistance is made of a cermet of a Pt—Au alloy and zirconia, and the inner pump electrode is located, from among surfaces defining the first internal space, at least on a surface farthest from a heater part in a thickness direction of the element, and is not located on a surface closest to the heater part in the thickness direction.

Abstract: A sensor element includes an element body provided with a measurement-object gas flow section therein; a measurement electrode disposed in the measurement-object gas flow section; a measurement-object-gas side electrode disposed on the element body; a reference electrode disposed inside the element body; and a reference-gas introduction section having a reference-gas introduction space and a porous reference-gas introduction layer, the reference-gas introduction space introducing a reference gas into the element body, the porous reference-gas introduction layer causing the reference gas to flow from the reference-gas introduction space to the reference electrode. Limiting current A as a limiting current when oxygen is pumped out from a periphery of the reference electrode to a periphery of the measurement-object-gas side electrode is 30 ?A or lower, A×Ra as a product of a diffusion resistance Ra [/mm] of the reference-gas introduction space and the limiting current A is 50,000 or smaller.

Abstract: Disclosed herein are methods and devices for a cell-free assay platform that enables measurement of membrane protein function by measuring the events that are induced by ligand binding or other stimuli.

Abstract: Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis.

Abstract: Articles and methods for the active transport of molecules into, within, and/or from a matrix are generally described. In some embodiments, an electric field may be used to alter the position of the molecule with respect to the matrix. The electric field may be used to move the molecule to a new location within the matrix, remove the molecule from the matrix, or infuse the molecule into the matrix. For instance, the electric field may be used to move a molecule having a binding partner within the matrix into or away from the vicinity of the binding partner. In some embodiments, the position of the molecule may be altered by exposing the molecule to an electrodynamic field. In some such embodiments, the molecule exposed to the dynamic electric field may have enhanced mobility and minimal adverse matrix interactions relative to conventional molecular transport methods, and in some cases, a molecule exposed to an electrostatic field.

Abstract: A hydrogen gas sensor utilizing electrically isolated tunneling magnetoresistive stress sensing elements is disclosed. The hydrogen gas sensor comprises: a deformable substrate, a magnetoresistive bridge stress sensor located on the deformable substrate, an electrical isolation layer covering the magnetoresistive bridge stress sensor, a magnetic shielding layer located on the electrical isolation layer, and a hydrogen sensing layer located above the deformable substrate. The hydrogen sensing layer is located in a plane perpendicular to the deformation of the substrate covering the electrical isolation layer. The hydrogen sensing layer is used for absorbing or desorbing hydrogen gas to generate expansion or contraction deformation and cause a stress change of the deformable substrate. The magnetoresistive bridge stress sensor is used for measuring a hydrogen gas concentration utilizing the stress change of the deformable substrate. It results in a hydrogen gas sensor with improved performance.

Abstract: A method of manufacturing is provided. The method can include determining a cross-sectional shape of an object to be inspected using a sensor configured with a sensor coil. The method can also include providing a substrate having a profile matching the cross-sectional shape of the object. The method can further include applying a dielectric material to the substrate in a patter matching a shape of the sensor coil. The method can also include forming a first layer of a first material on the dielectric material by sputtering particles of the first material on the dielectric material in the pattern and forming additional layers of the first material atop the first layer by iteratively depositing the additional layers in the pattern via an additive manufacturing technique. A sensor including a sensor coil formed via the method is also provided.

Abstract: Systems, methods, and apparatuses for inspecting a tank containing a flammable fluid are provided. A vehicle configured to inspect the tank can include a propeller, a battery, a control unit, an inspection device, and a ranging device. The battery provides power to the propeller, the control unit, the inspection device, and the ranging device. The control unit generates a map of the tank and determines a first position of the vehicle on the map. The propeller moves the vehicle through the flammable fluid in the tank. The inspection device includes a pulsed eddy current array to obtain inspection data indicating a quality of a tank wall. The control unit causes the propeller to move the vehicle from the first position to a second position within the tank. The control unit obtains first inspection data indicating the quality of the tank wall, and stores the first inspection data.

Abstract: Disclosed herein is a chemical sensing system, comprising: a sensor configured to adsorb an analyte; an electronic circuit to operate the sensor; and a microcontroller in communication with the sensor and the electronic circuit. The microcontroller can also be configured to provide a real-time signal indicative of a concentration of the analyte. The sensor can comprise a microelectromechanical system (MEMS) resonator and a sensing film configured to adsorb the analyte, the sensing film coating at least a portion of the sensor. The MEMS resonator can comprise a second sensor, such as an impedimetric sensor to measure at least a second property of the sensing film. The electronic circuit can process signals stemming from at least two properties of the same sensing film, such as the changes in mass and dielectric constant of the same sensing film due to adsorption of analyte.

Abstract: The present disclosure provides a system and method for real-time visualization of a material during ultrasonic non-destructive testing. The system includes a graphical user interface (GUI) capable of showing a three-dimensional (3-D) image of a composite laminate constructed of a series of two-dimensional (2-D) cross sections. The GUI is capable of displaying the 3-D image as each additional 2-D cross section is scanned by an ultrasonic testing apparatus in real time or near real time, including probable defect regions that contain a flaw such as a hole, crack, wrinkle, or foreign object within the composite. Furthermore, in one embodiment, the system includes an artificial intelligence capable of highlighting defect areas within the 3-D image in real time or near real time and providing data regarding each defect area, such as the depth, size, and/or type of each defect.

Abstract: A downhole imaging tool and method of operating the tool in a wellbore. An imaging sensor array at an end of the tool is rotatable about a longitudinal axis of the tool to image the well by sweeping out a 2D area of the well. Actuators in the tool provide rotation and/or extension of the sensor array to change perspective. An ultrasound phased-array may be used to measure and identify features of the well or objects.

Abstract: This invention provides a method for finding the remnant thickness of a structure. A feature of guided waves known as the cut-off property is used to determine the remnant thickness of structures. Fundamental guided wave modes do not possess cut-off property, but higher order modes do. The cut-off thickness of a particular mode is the minimum thickness required for that mode to travel through the guided medium. The invention uses a wide-bands of frequency and wavelength to generate the modes using appropriate magnets and excitation signal shape to provide a low cost and rapid evaluation of remnant thickness of structure.

Abstract: This optical fiber distribution measurement system of distributed optical fiber sensing type includes: a tunable wavelength distributed feedback LD (1) for obtaining a DTSS signal through frequency shift analysis; an external resonance laser (2) for obtaining a DAS signal through phase shift analysis; a pulse compression coding circuit (4) including an intensity modulator (4a) and an phase modulator (4b); an acousto-optic switch (5); an erbium doped optical fiber amplifier (6); a circulator (7); a diversity device (8); a digitizer (11); a CPU (12); and a serial transfer interface (13). Through calculation on discrete signals sent from the digitizer (11), the CPU (12) converts an analyzed Rayleigh frequency shift signal obtained as the DTSS signal, to phase error, and corrects an analyzed phase signal obtained as the DAS signal, by the phase error.

Abstract: A cost of a testing device is reduced. A structure of a testing device is simplified. A testing device capable of testing with higher accuracy is provided. A testing device (10) has a structure including a sending unit (13), a receiving unit (14), a control unit (11), and a display (15). The control unit includes a memory portion (21) and an arithmetic portion (22). The sending unit has a function of generating a pulse signal for a probe (40) to generate an ultrasonic wave (51). The receiving unit has a function of generating a first signal including a first analog data (D1) on the basis of the input single input from the probe. The memory portion has a function of storing the first analog data. The arithmetic portion has a function of generating an image signal (S0) output to the display on the basis of the first analog data stored in the memory portion. The display has a function of displaying an image based on the image signal.

Abstract: A fastening arrangement fastens a sample holder to a force measuring device. The fastening arrangement has a sample holder, a counterpart holder on the side of the force measuring device. The counterpart holder has a sample holder receptable. The sample holder has a planar abutment surface and the sample holder receptacle has a flat counterpart abutment surface. The sample holder has a positioning element and a fixing element. The sample holder receptacle has a counterpart positioning element and a counterpart fixing element. The positioning element and the counterpart positioning element uniquely define a relative position between the sample holder and the counterpart holder together with the abutment surface and the counterpart abutment surface. The fixing element and the counterpart fixing element hold the sample holder and the counterpart holder against one another and force the abutment surface and the counterpart abutment surface against one another.

Abstract: Safety systems and material testing systems including safety systems are disclosed. An example material testing system includes: at least one actuator configured to control one or more operator-accessible components of the material testing system; an actuator disabling circuit configured to disable the at least one actuator; and one or more processors configured to: control the at least one actuator based on a material testing process; monitor a plurality of inputs associated with operation of the material testing system; determine, based on the plurality of inputs and the material testing process, a state of the material testing system from a plurality of predetermined states, the predetermined states comprising one or more unrestricted states and one or more restricted states; and control the actuator disabling circuit based on the determined state.

Abstract: The present invention discloses a circulating multidimensional liquid chromatography and application thereof. The liquid chromatography comprises an infusion device, a sampling device, a collecting-resampling device, a chromatographic column switching device and a detecting device which are connected sequentially, wherein the collecting-resampling device comprises a collecting valve and a sample ring, and the collecting valve is connected with the sample ring; the sampling device is successively connected with the collecting valve and the chromatographic column switching device; the detecting device is also connected with the collecting valve; and the collecting valve is a three-slot three-position multi-way valve.

Abstract: Disclosed is a chromatographic separation column assembly (100) comprising a column cylinder (120) having a cylinder wall (126) including an inner wall surface (124) partially defining a column volume (50), and a column component (110/130) insertable into to the cylinder (120), wherein at least an edge region (113/133) of the column component is intended to be in contact or adjacent a part of the inner wall surface (124) in use, the edge region and the contacting or adjacent part of inner wall surface each being formed from a compatible heat fusible material or materials, and wherein at least the cylinder wall in the area of the contacting or adjacent part of the inner wall is formed from a material which allows transmission of the light energy needed to cause said fusing of the adapter plate edge region to the inner wall surface.

Abstract: A modular gas detection system includes a primary gas chromatograph, a constant volume extractor positionable to provide a continuous fluid sample to the primary gas chromatograph, and a total hydrocarbon analyzer. The modular gas detection system also includes a processing device and a memory device including instructions executable by the processing device for causing the processing device to perform operations. The operations include adjusting a detection scheme of the primary gas chromatograph to update a detection range for the continuous fluid sample to detect different hydrocarbons within a single column. Further, the operations include controlling routing of the continuous fluid sample from the constant volume extractor to the primary gas chromatograph and the total hydrocarbon analyzer.

Abstract: A system for providing an indication of the presence of molecular structures in a medium is provided. The system includes a radio frequency (RF) wireless antenna, batteryless sensor, and a network analyzer. The sensor has an ultra-high frequency dipole antenna that transmits data to the RF wireless antenna and a sensing element. The sensing element is operatively coupled to the dipolar antenna and detects the presence of molecular structures. When molecular structures are detected, data indicative of the presence of the molecular structures is transmitted to a radio frequency (RF) wireless communication antenna from the dipole antenna. The network analyzer receives the data from the RF wireless antenna and analyzes the data to determine a concentration of molecular structures.

Abstract: [Object] To provide an arithmetic device, an arithmetic method, and a gas detection system that are capable of easily correcting deterioration over time of a detection element. [Solving Means] The arithmetic device includes a calculation unit. The calculation unit calculates a correction coefficient from a detection element that causes a resonant frequency change by adsorption of gas on the basis of a resonant frequency change amount associated with a humidity change of the detection element in a degraded state and a resonant frequency change amount associated with a humidity change of the detection element in an initial state that was acquired in advance, and corrects the resonant frequency change amount of the detection element in the degraded state by using the correction coefficient.

Abstract: A learning model generation support apparatus 10 is an apparatus for supporting generation of a learning model to be utilized in odor detection using an odor sensor that reacts to a plurality of types of odors. The learning model generation support apparatus 10 includes a data acquisition unit 11 that acquires sensor data output by the odor sensor under specific measurement conditions and condition data specifying the measurement conditions, and inputs, as training data, the acquired sensor data and condition data to a machine learning engine 31 that generates the learning model, and a condition setting unit 12 that acquires a predictive accuracy output by the machine learning engine in response to input of the training data, and sets new measurement conditions for when the odor sensor newly outputs sensor data as training data, based on the acquired predictive accuracy.

Abstract: A method for measuring the concentration of fluorine gas, which includes irradiating a halogen fluoride-containing gas with ultraviolet light in which the ratio (WX/WF) of the maximum value (WX) of ultraviolet light intensity in the wavelength region of less than 250 nm with respect to the ultraviolet light intensity (WF) at a wavelength of 285 nm is 1/10 or less, and measuring the absorbance at a wavelength of 285 nm to obtain the concentration of fluorine gas contained in the halogen fluoride-containing gas.

Abstract: A sensor and method for the rapid detection of fluoride containing gaseous species specifically the chemical warfare agents Sarin and Soman nerve gas, in which a chemically sensitive composition containing dye indicator molecules complexed with a heavy metal salt is exposed to an environment under surveillance for toxic gasses. In one embodiment the sensing composition is introduced into a polymer-based substrate. The detection composition reacts with hydrogen fluoride which is a decomposition by-product of Sarin and Soman gas so as to change the color of the dye indicator, in one embodiment being pentamethoxy red, that is to change the color of the polymer-based substrate from colorless to a dark purple color. The complex of pentamethoxy red with the exemplary heavy metal salt, zirconyl chloride, is specific for Sarin and Soman nerve gas; it does not react to certain other toxic gases.

Abstract: An analyzer and a control method thereof, a detection system, and a storage medium are provided. The control method of the analyzer includes: determining whether the analyzer obtains an analysis parameter corresponding to a detection chip used for detection: requesting and obtaining the analysis parameter in a case of being determined that the analyzer does not obtain the analysis parameter; and performing detection on the detection chip and analyzing a substance to be analyzed contained in the detection chip by using the analysis parameter to obtain analysis data of the substance to be analyzed in a case of being determined that the analyzer obtains the analysis parameter.

Abstract: A method for determining a reference value of a wine for feasibility of filling an aluminum can, the method comprising: acquiring a pH, an alcohol concentration, and a free sulfite concentration for multiple kinds of wines; calculating a molecular SO2 concentration of each of the multiple kinds of wines from acquired values of the pH, the alcohol concentration, and the free sulfite concentration; enclosing the multiple kinds of wines into aluminum cans of an identical type, respectively, thereby obtaining multiple kinds of canned wines; putting the multiple kinds of canned wines in storage and evaluating quality of the canned wines after the storage; and determining an upper limit value of the molecular SO2 concentration based on an evaluation result obtained from the evaluating.

Abstract: A system and process may be used to test water samples to measure ATP and/or estimate a microbial population, for example using an adenosine triphosphate (ATP) based assay. The system includes a device that is use in combination with single-use or disposable cartridges. The cartridge receives the water sample and is pre-loaded with one or more reagents. The device receives the cartridge and contains physical, electronic and/or mechatronic devices that interact with cartridge. One or more actions such as metering, mixing and conveying are performed automatically by elements of the device and/or cartridge. A sensor in the device measures light produced in the cartridge from a reaction with ATP in the water sample. Optionally, the cartridge also contains a pre-loaded amount of ATP, which is used to provide an internal reference or calibration measurement.

Abstract: A shaped charge target apparatus and method for using a target composed of synthetic material, thereby allowing for repeatable testing at a variety of density and hardness values.

Abstract: The present invention relates to a deep rock in situ environment reconstruction and integrated three-dimensional mechanical-thermo-acousto-seismic-flow testing method, which comprises: preparing a cubic sample; placing the cubic sample in a sample holder; extending the 6 indenters to butt with the sample holder; butting 6 butting indenters with the 6 indenters; butting each of 6 hydraulic actuators with one of the butting indenters, performing stress loading on the cubic sample by the hydraulic actuator, filling a fluid medium into the cubic sample by a percolation medium channel, and dynamically measuring related parameters. The present application can achieve three-way multi-parameter synchronous monitoring and acquisition of deformation, acoustic emission, ultrasonic wave, temperature field, percolation field and heat flow field.

Abstract: A method includes simultaneously measuring electrophysiological responses and contractility responses of a plurality of cells forming a tissue culture using a system comprising a sensor array configured to simultaneously measure the electrophysiological responses and the contractility responses of the plurality of cells forming the tissue culture. Fabrication techniques for making such systems include: forming a sensor array comprising an interpenetrating arrangement of IDEs and electrodes of a MEA in or on a substrate surface; forming a plurality of contacts for interfacing the system with one or more external devices in or on the substrate surface; and forming leads between the plurality of contacts and the sensor array.

Abstract: A laser suitable for use under field conditions to generate pulsed laser for detecting malaria using transient vapor nanobubbles can include a frequency doubled passively Q-switched microchip laser. The passively Q-switched microchip lasers can include suppression techniques for the unwanted fundamental wavelength in addition to using anti-reflective coatings. The pulsed laser disclosed herein can generate pulses with a high peak power as a result of high energy in conjunction with short pulse duration in the range of hundreds of picoseconds. The high peak power can be enough to generate the photo-thermal transient vapor nanobubbles for malaria detection and/or treatment.

Abstract: A computer system is provided for determining the relative effectiveness of anti-cancer drugs. The interface has selectable options, including an option to manage drug testing parameters, and enables user selection of desired drug testing parameters in relation to a virtual well plate associated with a physical well plate of a spectrophotometer. The computer system causes the spectrophotometer to start a drug test, wherein the physical well plate includes at least one test well containing viable cancer cells; and at least one drug candidate in a predetermined concentration; and at least one control well containing the viable cancer cells alone. The system records the optical density of the well at a predetermined wavelength at selected time intervals for a selected duration of time, and stores the optical density and time measurements in the database.

Abstract: Methods of assessing cytolysis of cancer cells are provided, which include: providing a cell-substrate impedance monitoring device operably connected to an impedance analyzer, adding target cells characterized as cancer cells to a well of the device adding effector cells to the well to form a test well, where the effector cells are immune cells obtained or derived from a same patient as the target cells; monitoring cell-substrate impedance of the test well before and after adding the effector cells and optionally deriving an impedance-based parameter from the impedance; and determining effectiveness of effector cell killing of the target cells by comparing the impedance or impedance-based curves over time.

Abstract: Provided are an expression inhibitor of an inflammation promoting factor based on the discovery of a new factor influencing the expression amount/level of an inflammation promoting factor, and a development tool therefor. Provided are also a diagnostic agent and a diagnosis method for immune diseases, inflammatory diseases, painful conditions and similar. More specifically provided are: an expression inhibitor of an inflammation promoting factor containing at least one kind of inhibitor selected from the group consisting of RBMS2 expression inhibitor and RBMS2 function inhibitor; a screening method using as an indicator the expression or the function of RBMS2; an expression cassette useful for the method; as well as a diagnostic agent containing a product detection agent for RBMS2 gene expression and disease detection method using as an indicator RBMS2 gene expression amount/level.

Abstract: Disclosed herein are trogocytosis based TCR ligand discovery platforms and methods of using the same, trogocytosis based TCR discovery platforms and methods of using the same, and trogocytosis based ligand discovery platforms and methods of using the same. Also disclosed herein are isolated cells, nucleotides, sequences, and sequence databases produced using trogocytosis based discovery platforms.

Abstract: Disclosed herein are human trophoblast stem (hTS) cells, differentiated cells thereof, derivatives thereof such as cellular mass, and uses thereof. The isolation of hTS cells can express FGF4, FGFR-2, Oct4, Thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell. The hTS cells are able to derive into specific cell phenotypes of the three primitive embryonic layers, produce chimeric reactions in mice, and retain a normal karyotype and telomere length. In the hTS cells, Oct4 and fgfr-2 expressions can be knockdown by bFGF. The hTS cells could apply to human cell differentiation and for gene and cell-based therapies.

Abstract: Provided herein are methods, systems and kits for detection of certain placental proteins, such as PAPP-A and ADAM-12, for example, in a serum sample from an individual to classify gestational ages above and below a specific threshold, such as for use in determining for use in determining gestational age for making clinical or personal decisions without ultrasound.