Abstract: A dual-flange stent can have a therapeutic effect that can bring about a marked increase in patency. The dual flanges of the stent can comprise a first discrete flange component and a second discrete flange component. One or both flange components can include a magnetic element. The stent can further comprise a shaft connecting the flange components. At least one of the flanges can transition between a first configuration and a second configuration, where the first configuration is compact and the second configuration provides a large tissue-compressing surface. In one instance, the transition to the configuration with a large tissue-compressing surface can include filling a balloon with saline or another fluid. The first flange and the second flange may be drawn together to compress interposed tissue of the stricture.

Abstract: A radially expandable, tubular stent, includes a first section having a first crush resistance force and a second section have a second crush resistance force, wherein the first crush resistance force is less than the second crush resistance force. The first section is connected to the second section to form a tube, connection of the first and second sections extending in an axial direction of the tube.

Abstract: A growth stent and valve and methods for making and using the same. The growth stent and valve may be delivered to treat early stage congenital lesions, while expanding to adult vessel diameters. In selected embodiments, the growth stent and valve can comprise a frame and may have a covering on some portion to prevent blood flow through a wall of the frame. The growth stent and valve advantageously can maintain radial strength across an entire range of diameters necessary to treat a narrowed lesion from birth and childhood through adulthood as the vessels grow over the lifetime of a patient.

Abstract: Delivery systems for expandable elements, such as stents or scaffolds having spikes, flails, or other protruding features for delivering drugs and/or penetrating target tissue within a human patient and associated methods for using such systems. The delivery systems can be configured to deliver and position expandable structures within a body lumen (e.g., vessel). In addition, these delivery systems can also be configured to deploy and expand the expandable structures in the body lumen. The delivery systems can further be configured to engage with the expanded structure and collapse the structure for removal from the body lumen. The delivery systems can be configured to deliver another expandable structure or the same expandable structure to another body lumen, or the same body lumen, in a single procedure or during a plurality of procedures.

Abstract: Methods for crimping a stent on an expandable member of a delivery catheter, and devices and methods for treating a bifurcation are disclosed. A method for crimping includes positioning a stent having a first portion and a second portion over the expandable member, and non-uniformly crimping the stent to the expandable member. The method can include routing an elongate shaft under the second portion of the stent and through the side hole so as to be routed external to the first portion. The stent second portion can be crimped so that the elongate shaft can be slidably disposed relative to the stent second portion prior to deployment of the stent.

Abstract: A percutaneous transluminal angioplasty device includes a catheter defining one or more lumens. A filter is coupled to the catheter adjacent a distal end of the catheter, and the filter is movable between an unexpanded and expanded configuration via a filter activation wire that extends through a lumen. An expandable balloon is coupled to the catheter proximally of the filter, and a stent is disposed over at least a portion of the balloon. To deploy the stent to a target site, the filter is first moved into its expanded position via the filter activation wire. Then, the stent is expanded, and the balloon is inflated to expand the stent further radially. The balloon is then deflated, the filter is contracted, and the catheter, balloon, and filter are removed from the body.

Abstract: Disclosed is a method, apparatus, and kit for assisting the expansion of a self-expanding stent, especially within highly curved or tortuous blood vessels. An elongated pusher having an expandable distal mesh portion can be positioned within a self-expanding stent, expanding during delivery to provide extra expansion force to the stent to ensure the stent properly expands.

Abstract: An implant delivery system is described. The implant delivery system utilizes an implant, implant wire, delivery sheath, and a torque device. The torque device may include a cutting element to slit the delivery sheath and a clamp device to fix the position of the implant delivery wire.

Abstract: A versatile orthopedic device is arranged to convert between ligament and osteoarthritis treatment, and to accommodate a variety of leg anatomies. The orthopedic device is preferably configured as a double-upright brace indicating struts, frame component sections and associated hinges preferably intended to be along both medial and lateral sides of a wearer's leg. A strap kit with an unloading strap system may be added to the orthopedic device for conversion into an orthopedic device for osteoarthritis relief.

Abstract: A medical auxiliary equipment, in particular to an adjustable toe orthotic device, with a primary support and a secondary support connected by rotation; the primary and secondary supports are both provided with bandages, separately used for tying the primary support to the arch of the foot and the secondary support to the toe. Pivots of the primary and secondary supports are arranged with a lifting component, which is used to abut on the deformity point of the toe, and by adjusting the lifting distance of the lifting component, it adapts to different degrees of toe deformity. The device adapts to different toe deformities through the adjustment of the lifting degree of the abutting surface, so that the orthotic abutment of the toe orthotic device is always in the state that best matches the toe deformity of users.

Abstract: Illustrative embodiments of a sling apparatus for supporting an arm of a person include a garment to be worn on the torso, and arm support elements mounted on the garment that are configured to support the arm of the person wearing the garment in at least two positions with respect to the torso. Illustrative implementations of the two positions include a first position of the arm having the elbow extended with a shoulder associated with the arm of the person being in a neutral rotation orientation, and a second position of the arm having the shoulder associated with the arm being in an adducted, internal rotation position with the elbow flexed.

Abstract: Certain embodiments of the present application relate to an adjustable ostomy wafer system including an ostomy wafer and an insert ring. The ostomy wafer includes an adjustable layer with an effluent opening through which effluent flows, and the adjustable layer has a body-facing side and a non-body-facing side. The insert ring is capable of providing or increasing convexity of the adjustable layer when the insert ring is pressed against the non-body-facing side of the adjustable layer.

Abstract: A urine removal device includes a plurality of layers suitable to capture and transfer urine. A conduit system is disposed inside of the device and extends from the proximal portion of the device, where it interfaces via an outlet conduit member, to the distal end of the device where it draws in urine from the device. The device allows air flow through the device to support suction that is applied. The fluid layer system has at least one conduit configured to draw urine from the distal portion of the device up to the proximal end of the device, and into the outlet conduit where it exits the urine removal device.

Abstract: An external urine collection system for collecting urine excreted by a user through the user's external urethral orifice includes a urinary assembly having a sleeve and a cup that define a collection chamber. The sleeve can be attached to an area around the user's external urethral orifice by an adhesive. The cup can be coupled to the sleeve through a male connector and female connector that form a liquid tight seal between the sleeve and the cup. An outlet is defined by at least one of the sleeve and the cup for draining urine excreted by the user into the urinary assembly.

Abstract: An oral appliance having an upper dental tray and lower dental tray. The upper dental tray and lower dental tray are connected by an elongated connector having receptacles at its proximal and distal ends for engaging laterally extending supports on the upper dental tray and lower dental tray, respectively. A backstop is positioned adjacent to each of the laterally extending supports to prevent movement of the connector in a predetermined direction.

Abstract: This application relates to a hand-held cooling device for supplying a cryogen to a target region for cryotherapy. The device can include a cryogen container configured to contain a first cryogen having a first temperature and a nozzle configured to spray a first modified cryogen to the target region, the first modified cryogen having a second temperature higher than the first temperature. The device can also include a cryogen temperature regulator configured to receive the first cryogen and output the first modified cryogen to the nozzle, the cryogen temperature regulator disposed closer to the nozzle than the cryogen container. The cryogen temperature regulator can include a holder tube, a porous structure disposed inside a holder tube and a heater disposed around the holder tube and heating the holder tube so as to increase the first temperature to the second temperature while the first cryogen passes through the porous structure.

Abstract: A whole-body hyperthermia system for raising the body temperature of the entire body of an individual to a predetermined target temperature and for stabilizing the body temperature at the target temperature comprises an apparatus means for raising the body temperature at a rate of at least 1° C./hour, and at least a second thermal means for further adjusting the body temperature to the target temperature Tb. The second thermal means comprises a fluid circuit, which is at least partially within the individual, and a fluid, heated by a heat exchanger to a set temperature is circulated through the fluid circuit.

Abstract: A device for a medical or cosmetic treatment based on heat is provided. The device includes an impermeable backing layer and an adhesive layer in contact with the backing layer. The device also includes an alkali metal selected from a single, free alkali metal and an alloy alkali metals, the alkali metal in contact with at least a portion of the adhesive layer to define a treatment region. The device also includes a release liner in contact with the adhesive layer and the treatment region. A heat delivery system or kit including the device and a method for its use are also provided.

Abstract: A conjunctival cover including an annular generally curved shell having a conjunctival portion structured to conform to and overly at least part of the conjunctiva of an eye. The annular generally partially spherical shell defines a generally central opening. The central opening is sized to leave a cornea of the eye substantially or partially uncovered when the conjunctival cover is applied to the eye.

Abstract: A method of deploying an ocular implant into Schlemm's canal of an eye. The method includes the steps of inserting a distal end of a cannula through a cornea of the eye and into an anterior chamber of the eye, the cannula having a distal opening extending from the distal end and through a side wall; placing the distal opening of the cannula into fluid communication with Schlemm's canal; advancing the ocular implant distally through the cannula with a delivery tool engaged with the ocular implant, a proximal portion of the ocular implant engaging the delivery tool proximal to a distal portion of the delivery tool; and disengaging the ocular implant and the delivery tool when the proximal portion of the ocular implant reaches the cannula distal opening. The invention also includes a system for practicing the method.

Abstract: A phacoemulsification system includes a phacoemulsification probe and a processor. The phacoemulsification probe includes (a) a needle configured for insertion into a lens capsule of an eye, and to be vibrated to emulsify a lens of the eye, (b) an irrigation channel for flowing irrigation fluid into the lens capsule, (c) an aspiration channel for removing material from the lens capsule, (d) a bypass channel fluidly coupled with the irrigation channel and with the aspiration channel, (e) a processor-controlled valve configured to control a level of fluid communication between the irrigation channel and the aspiration channel via the bypass channel, and (f) one or more sensors configured to measure fluid pressure at a distal portion of one or both of the irrigation channel and the aspiration channel. The processor is configured to adaptively adjust the valve based on the fluid pressure measured by the one or more sensors.

Abstract: A device for producing control data for a laser device for the surgical correction of defective vision. The device produces the control data such that the laser emits the laser radiation such that a volume in the cornea is isolated. The device calculates a radius of curvature RCV* to determine the control data, the cornea reduced by the volume having the radius of curvature RCV* and the radius of curvature being site-specific and satisfying the following equation: RCV*(r,?)=1/((1/RCV(r,?))+BCOR(r,?)/(nc?1))+F, wherein RCV(r,?) is the local radius of curvature of the cornea before the volume is removed, nc is the refractive index of the material of the cornea, F is a coefficient, and BCOR(r,?) is the local change in refractive force required for the desired correction of defective vision in a plane lying in the vertex of the cornea, and at least two radii r1 and r2 satisfy the equation BCOR(r=r1,?)?BCOR(r=r2,?).

Abstract: The present invention relates to a cutting device comprising: a laser source (1) for emitting an initial laser beam (11) in the form of pulses, a shaping system (2) positioned downstream of the femtosecond laser (1), for transforming the initial laser beam (11) into a single phase-modulated laser beam, an optical coupler (3) between the laser source (1) and the shaping system (2), the optical coupler (3) including an optical fibre (31), remarkable in that the cutting device further comprises a polarisation corrector (7) for modifying the polarisation of the initial laser beam (11) at an input end of the optical coupler (3) such that the polarisation of the laser beam at an output end of the optical coupler (3) corresponds to a desired reference polarisation.

Abstract: A photocoagulation apparatus of some embodiment examples is configured to apply both treatment light for subthreshold coagulation and an OCT scan to a retina via a probe inserted in an eye. Upon receiving a user's instruction, the apparatus applies the treatment light to the retina, and applies an OCT scan to the retina at least after the treatment light application. The apparatus compares the first OCT image constructed from OCT data of the retina acquired prior to the treatment light application and the second OCT image constructed from OCT data of the retina acquired after the treatment light application, thereby acquiring change information that represents a tissue change in the retina caused by the treatment light. The apparatus displays a change image based on the change information together with a retinal image.

Abstract: A method for modifying a refractive property of ocular tissue in an eye by creating at least one optically-modified gradient index (GRIN) layer in the corneal stroma and/or the crystalline by continuously scanning a continuous stream of laser pulses having a focal volume from a laser having a known average power along a continuous line having a smoothly changing refractive index within the tissue, and varying either or both of the scan speed and the laser average power during the scan. The method may further involve determining a desired vision correction adjustment, and determining a position, number, and design parameters of gradient index (GRIN) layers to be created within the ocular tissue to provide the desired vision correction.

Abstract: A device for ultrasonic object detection, having at least two independent transducers that are able to emit at least two ultrasonic signals respectively in order to produce reflected ultrasonic signals in return, and able to receive the reflected ultrasonic signals, wherein it has an electronic processing unit configured so as to convert the received reflected ultrasonic signals into respective spectrograms, in an audible frequency band, and form respective audible temporal signals through an inverse Fourier transform of the spectrograms.

Abstract: A cot can include a support frame that extends between a front end and a back end. A front leg and a back leg can be slidingly coupled to the support frame. A front actuator can be coupled to the front leg and slide the front leg to retract and extend the front leg. A back actuator can be coupled to the back leg and slide the back leg to retract and extend the front leg. One or more processors can execute machine readable instructions to receive signals from one or more sensors indicative of the front end of the cot and the front leg. The one or more processors can actuate the back actuator to extend the back leg to raise the back end of the cot, when the front end of the cot is supported by a surface and the front leg is retracted a predetermined amount.

Abstract: A surgical table for supporting a patient during a surgical procedure and including a patient support structure, a first support structure, and a second support structure. The patient support structure is configured to support the patient during the surgical procedure and may be operably coupled at a first end to the first support structure and at a second end to the second support structure. The first support structure includes a first column and a first displacement apparatus operably coupling the first column to the first end of the patient support structure.

Abstract: A surgical drain tray assembly includes a fluid impermeable first layer and a porous second layer positioned on the fluid impermeable first layer. The fluid impermeable first layer includes a drain outlet, a basin, and a sloping surface angled toward the basin, the drain outlet being positioned within the basin. The porous second layer may be formed of a foam material and includes a top work surface. Fluids spilled onto the work surface pass through the porous second layer to the fluid impermeable first layer. The sloping surface of the fluid impermeable first layer conveys the fluids toward the basin for draining through the drainage outlet.

Abstract: A small electric vehicle includes: left and right motors connected so as to respectively transmit power to left and right driving wheels; left and right rotation speed sensors; an inclination sensor; a joystick-type operation element; and a control unit, wherein it is configured to calculate target rotation speeds of the left and right motors, based on a target vehicle speed provided by an inclination angle in consideration of the pitch angle and the roll angle detected through the inclination sensor and by an operation position of the operation element, and on a target vehicle angular velocity provided by the inclination angle, by the operation position of the operation element and by the actual speed of the vehicle, and control the left and right motors such that actual rotation speeds of the left and right motors follow the respective target rotation speeds.

Abstract: A mobility vehicle may comprise a frame, a first pivot arm, a second pivot arm, and a suspension assembly. The first pivot arm may be coupled to the frame and coupled to a drive wheel. The second pivot arm may be coupled to the frame and coupled to a ground engaging caster wheel. The suspension assembly may be coupled to the frame. The suspension assembly may include a first spring assembly and a second spring assembly. The first spring assembly may be disposed about a first spring axis and coupled to the first pivot arm. The second spring assembly may be disposed about a second spring axis and coupled to the second pivot arm. The first spring axis and the second spring axis may be disposed relative to each other at an angle of no greater than about 150° when the mobility vehicle is operating on horizontal ground.

Abstract: A patient turning apparatus is disclosed. The apparatus comprises a reconfigurable support platform comprising a plurality of laterally extending support slats configured for pivotal movement about a longitudinally extending central region of the platform. At least one support slat is configured to follow a pivotal movement of a longitudinally adjacent support slat about the central region, through at least a portion of a pivotal range of movement of the longitudinally adjacent support slat. The apparatus further comprises means operable to control pivotal movement of at least one support slat of the platform about the central region.

Abstract: There is described a patient lift apparatus comprising a supporting frame, a boom portion connected to the supporting frame via a pivot joint (PJ1) to allow the boom portion to pivot with respect to the supporting frame about a pivot axis (PA1), a boom actuator to mechanically assist pivotal movement of the boom portion with respect to the supporting frame, and a leg/knee support connected to the supporting frame. The leg/knee support is configured to be selectively releasable from the supporting frame and comprises a manually-operable release mechanism forming an integral part of the leg/knee support, which manually-operable release mechanism is configured to allow selective release of the leg/knee support from the supporting frame.

Abstract: A human lift apparatus is disclosed. In various embodiments, the lift apparatus includes a substantially vertical guide rail; a carriage positioned to be moved up and down along the guide rail; a drive mechanism coupled to the carriage and configured to move the carriage at a controlled rate along the guide rail; and a tiltable seat coupled mechanically to the carriage in a manner that allows the seat to tilt about a substantially transverse tilt axis that is substantially parallel to the floor and runs substantially across the seat at a depth that enables a human subject to be seated on the tiltable seat with the center of gravity of the human subject being between the tilt axis and a back end of the seat. The tiltable seat is tiltably mounted in a manner and location that allows the tiltable seat to tilt down, with a front edge of the seat lower than the back edge of the seat, as the center of gravity of the human subject is shifted to a position forward of the tilt axis.

Abstract: An inflatable neck traction device includes a supporting portion and a bearing portion. The height of the top surface of the bearing portion is lower than that of the supporting portion. The supporting portion has a neck support body and two shoulder abutting bodies, and can be provided therein with a first airbag and two second airbags. An inflation device can be connected to the airbags. When a user rests on the device in a supine position, the top surface of the neck support body supports the neck, and the shoulder abutting bodies abut against the shoulders. The inflation device inflates or deflates the airbags to displace the neck support body along a first axis and the shoulder abutting bodies along a second axis to change the force exerted by the neck support body and shoulder abutting bodies on the neck and shoulders to achieve cervical traction effects.

Abstract: An exoskeleton wearable on a body of a human having two legs, the exoskeleton comprising a first HAA joint and a second HAA joint to assist the human with leg abduction and adduction movements that are parallel to a frontal plane, each of the first and the second HAA joints having an actuator, each actuator including a motor and a clutch. The exoskeleton further comprises a sensor system for measuring a combined center of mass of the human and the exoskeleton in the frontal plane and a step width of the human in the frontal plane. The exoskeleton further comprises a controller that outputs adjustment angles for each of the first and the second HAA joints based on the center of mass and the step width. The first and the second HAA joints are respectively rotated based on the respective output adjustment angles.

Abstract: A motion assistance apparatus includes a force transmitting frame configured to support a distal part of a user, a slider configured to slide in the force transmitting frame, and a driving frame connected to the slider and configured to slide with respect to a proximal part of the user.

Abstract: An actuator system for an orthotic device includes an actuator assembly and a driven joint member connected remotely from the actuator assembly by flexible cabling to permit flexibility in positioning the driven joint member relative to the actuator assembly. The actuator system includes an actuator assembly having a motor and a first portion of a transmission assembly that provides a speed reduction of a motor speed to an output speed. The driven joint member has an output portion of the transmission assembly and a connector component for connecting the driven joint member to a brace component of the orthotic device. The driven joint member including the output portion of the transmission assembly is connected remotely from the actuator assembly by flexible cabling that runs between the actuator assembly and the driven joint component, to permit flexibility in positioning the driven joint member relative to the actuator assembly.

Abstract: Systems and methods related to the field of cardiac resuscitation, and in particular to devices for assisting rescuers in performing cardio-pulmonary resuscitation (CPR) are described herein. The system includes a chest compression device having force sensing capabilities, for providing feedback in enhancing the quality of acute care. The force sensor(s) may exhibit varying resolutions over different dynamic force ranges, for example, to provide information helpful to the resuscitative treatment. Chest compression devices that are able to sense force may be able to assist a system in providing accurate chest compression depth and rate information, as well as assess the amount of work exerted by one or more rescuers during the course of resuscitation.

Abstract: Disclosed are systems and processes related to cardiopulmonary resuscitation (CPR). One embodiment of the system comprises an inspiration chamber and an expiration chamber, which work cooperatively to provide gas (e.g., Oxygen (O2)) to a subject (e.g., human patient) during inspiration and extract and expel expired gas (e.g., Carbon Dioxide (CO2)) from the subject during expiration as a medical professional applies CPR to the subject. In other words, this disclosure provides systems and processes that allow for substantially synchronous chest compressions with positive pressure active inspirations and, also, substantially synchronous chest decompressions with negative pressure active expirations.

Abstract: A negative pressure massage device with cold feeling mechanism and a massage stick thereof are provided. The massage stick includes a stick body and a refrigeration module. The stick body includes a cover assembly, an end cover connected to the cover assembly, and a temperature transmitting member. The end cover includes a negative pressure connection hole. The temperature transmission member includes a suction port. The stick body further includes an air pipe communicates with the negative pressure connection hole and the suction port. The refrigeration module arranged inside of the stick body. The refrigeration module including a thermoelectric cooling chip and a heat sink. The thermoelectric cooling chip including a cold end and a hot end. The cold end attached to the temperature transmitting member. The hot end thermally contacts with the heat sink.

Abstract: Compression garment systems may include a trunk garment and a leg garment to be positioned about a trunk and leg of a body to provide compression therapy thereto. The trunk garment and the garment may include a plurality of controllable pressure applying regions to move lymph from the leg and trunk.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: The present invention relates to a bag containing preprepared injectable drug(s) and/or diluents for injectable drugs to be administered by intravenous (IV) application to a patient, said bag having an integrated flushing option.

Abstract: The present disclosure relates to relates to improved dietary supplement compositions formulated in a therapeutic effective amount for enhancing cognitive support and brain health. Specifically, the present disclosure relates to dietary and nutritional supplement compositions administered to a mammal in a therapeutically-effective amount to provide cognitive support and enhance overall brain health. The present disclosure further relates to a method of supporting cognitive health in a mammal comprising administering to the mammal in need thereof a therapeutically effective amount of a nutritional supplement comprising a combination of a carotenoid and an adaptogen.

Abstract: The present disclosure provides methods for safe and efficacious administration of esketamine.

Abstract: In various embodiments, methods are provided for applying transcutaneous and/or epidural spinal cord stimulation with and without selective pharmaceuticals to restore voluntary control of hand function in tetraplegic subjects.

Abstract: Described herein are methods and compositions useful to reduce (partially/inhibit or completely—prevent) skin cancer development in an individual in need thereof.

Abstract: In a method of producing aqueous solutions of N-bromotaurine (Taurine Bromanine, NBrT) with taurine with latter addition of NaOBr, and emulsions of these solutions with Stable Produced Olive Oil (S.P.O.O.), so to use against hyper-proliferative and abnormally differentiating cells of human and mammalian origin. In addition, due to the hyper-proliferation of keratinocytes in psoriatic skin, the methodology and subsequent use of the aqueous solutions and emulsions derived from this invention, containing NBrT and taurine, and S.P.O.O. against the lesions of psoriasis. With the method of this invention, the solutions derived and applied on cells in vitro beneficially provide maximization of NBrT anti-proliferative properties on abnormally differentiating and hyper-proliferating cells of human and mammalian origin by restoring NBrT anti-proliferative activity in a solution, whilst leaving unaffected the proliferation of normally dividing human fibroblasts.