Abstract: A moving device includes: two leg portions each including an end-portion wheel and an intermediate wheel; a placement portion supported by the two leg portions; and a control unit configured to control the two leg portions. The moving device is configured such that, under a state of four-wheel ground contact in which the end-portion wheel and the intermediate wheel are in contact with the ground, when the end-portion wheel is moved from the boarding area to the step of the escalator and/or when the end-portion wheel is moved from the step to the landing area of the escalator, a wheel speed of the end-portion wheel is controlled by the control unit.

Abstract: The present application provides a collapsible wheelchair, including a front support frame, a backrest bracket, a rear support frame and a bracket connecting rod, which are hinged with each other to form a first connecting rod mechanism; the seat connecting rod is hinged with the front support frame and a seat bracket respectively; the front support frame, the backrest bracket, the seat bracket and the seat connecting rod form a second connecting rod mechanism; a hinge point of the backrest bracket and the seat bracket is located above a central plane of the seat bracket.

Abstract: An electric bed includes a base frame and a sliding unit. The base frame is provided with two parallel guide rails. Each of the two guide rails has a vertical wall, top and bottom walls extending respectively from top and bottom edges of the vertical wall, and a stopping wall extending upwardly from the bottom wall. The sliding unit includes a frame located above the two guide rails, and two slide portions disposed on a bottom side of the frame, and respectively and slidably disposed to the two guide rails in a way that the sliding unit is reciprocatingly slidable related to the base frame. As a result, a bed frame of the electric bed can slide towards the head of the electric bed when raising a user's back. The electric bed provides a sturdy and durable structure with a slight increase in weight.

Abstract: A patient support apparatus for supporting a patient is adapted to wirelessly communicate with one or more wall units. A controller onboard the patient support apparatus and/or a controller onboard the wall unit is adapted to use RF signals to determine a distance between the wall unit and the patient support apparatus. In some embodiments, the wall unit and/or patient support apparatus include an orientation sensor adapted to determine the geographic orientation of the wall unit and/or patient support apparatus. The patient support apparatus controller may use the geographic orientation information to determine if the wall unit is facing toward the patient support apparatus or not. The patient support apparatus may communicate with multiple wall units concurrently, and/or the wall unit may communicate with multiple patient support apparatuses concurrently.

Abstract: A patient support apparatus for transporting a patient over a floor surface is described herein. The patient support apparatus includes a drive system with a drive member, a user interface for receiving user commands from a user to operate the drive system, and a control system for operating the drive system. The control system includes a memory device configured to store a plurality of transition profiles and a controller configured to sense a plurality of positions of the drive member relative to the support structure, calculate a distance traveled by the patient support apparatus over the floor surface, compare the plurality of positions of the drive member and the distance traveled by the patient support apparatus with the transition profiles, and determine that the patient support apparatus is traveling on an inclined floor surface.

Abstract: Embodiments herein provide a modular and portable plug-and-train robot (1000) for providing hand rehabilitation. The modular and portable plug-and-train robot (1000) includes a housing (100) and a power source (200) for powering the modular and portable plug-and-train robot (1000) to provide the hand rehabilitation. The modular and portable plug-and-train robot (1000) also includes an actuator (300) mounted within the housing (100) and connected to the power source (200) for providing movements to the modular and portable plug-and-train robot (1000). Then the modular and portable plug-and-train robot (1000) includes a plug-in apparatus (400) for coupling the actuator (300) and a therapy tool (500) and an instrumented armrest (600) connected to the housing (100) for determining compensatory forces applied by a forearm of the user during the hand rehabilitation. The therapy tool (500) provides a single DOF movement to a hand for the hand rehabilitation.

Abstract: The present disclosure relates to an orthosis device for providing motor movement to a body part. The device comprises a plurality of sensors to sense a first set of motion signals, a control unit, at least one actuator, and a support structure. The support structure comprises a guide structure comprising a plurality of wires. The control unit generates a second set of motion signals and provides the same to the at least one actuator. The at least one actuator generates a force for movement of the plurality of wires of the guide structure of the support structure. The movement of the plurality of wires help in motor movement of the body part.

Abstract: A glove for preventing and relieving tenosynovitis is provided. The glove includes a glove body, a hand warming assembly is arranged at a lower part of the glove body; a control assembly and mounting bases are arranged at an upper part of the glove body. Each of the mounting bases is provided with an insertion block and includes a clamping sleeve; an adsorption magnetic ring is arranged at a lower end of the insertion block. A sliding rod elastically slides at a lower part of the insertion block; a heating plate is arranged at a lower end of the sliding rod; massage beads and a vibrator are arranged at the heating plate. The lower part of the insertion block is slidably provided inside the clamping sleeve, an inner wall of the clamping sleeve is circumferentially provided with a limiting magnetic ring.

Abstract: An apparatus for generating an acoustic energy pulse and delivering it into a body is described. The apparatus includes a generator for creating an acoustic energy pulse having an energy density field that can be measured at all points within a space in the shape of an imaginary cylinder having a length greater than or equal to 2 cm and a diameter. The cylindrically shaped space has a cylinder longitudinal axis oriented relative to a longitudinal axis of the energy pulse at an angle in the range from zero to twenty degrees. A minimum energy density for the pulse at all locations within the cylindrically shaped space is at least 50% of a maximum energy density for the pulse within the space.

Abstract: The present disclosure relates to a method of treating testicular pain. The method of treating testicular pain includes identifying a location of testicular pain in a human subject, coupling a vibration mechanism to a pelvic region of the human subject based on an identified location of testicular pain, and applying vibrations to the pelvic region to alleviate testicular pain.

Abstract: An apparatus, method and computer program of heating a sauna sweat room for providing a comfortable temperature and environment in the sauna sweat room for a pleasant sauna experience. The apparatus includes a heating unit comprising a heat accumulator and a duct for collecting a hot air and a cool air and enabling the mix of the collected hot and cool air for providing homogenous temperature in the sauna sweat room. The method includes receiving the hot air heated by the heat accumulator in the at least one duct, receiving in the at least one duct the cool air, mixing the received hot air with the received cool air to obtain a mixed air stream, directing at least part of the mixed air stream towards a lower section of the sauna sweat room via the second end of the at least one duct.

Abstract: The present invention falls within the technical field of Food Packaging and has been specifically created to cater to the needs of Enteral Nutrition Foods Administered by a Closed System, defining itself as an opening device that is part of an aseptic carton packaging for exclusive use through connection to the enteral feeding set. Its design redefines traditional aseptic carton packaging (used in open enteral systems) for a closed enteral system packaging, as its features allow for the infusion of the product through the enteral feeding tube and preserve the packaging's barriers and airtightness without exposing the product to the environment, eliminating handling and the consequent need for a specific preparation area.

Abstract: A connector assembly disclosed herein includes a male part and a female part. The female part includes a cylindrical body extending about a central axis, a fitting portion configured to be sealingly fitted to a medical injection device, and a spike. An annular gap is formed between the cylindrical body and the spike to at least partly accommodate the male part. The female part further includes at least two ribs formed on an inner surface of the cylindrical body and protruding radially inwardly. Each ribs extends straight in parallel to the central axis and has an innermost fitting surface configured to be detachably fitted to corresponding threaded portions of the male part.

Abstract: A feeding device includes a fluid reservoir and a nipple configured to be attached to the fluid reservoir. The nipple includes a body portion defining a compartment configured to contain a liquid so as to mimic a feel of a mother's breast. The body portion comprises a nipple tip comprising a fluid outlet. The nipple includes a base member attached to the body portion, the base member including an attachment portion configured to attach the nipple to the fluid reservoir. The base member comprises a fluid inlet in fluid communication with the fluid reservoir. The nipple includes a fluid passageway extending through the compartment from the fluid inlet to the nipple tip, where the fluid passageway allows fluid to flow from the fluid reservoir to the fluid outlet. A valve member positioned on the base member adjusts a flow rate of fluid from the fluid reservoir into the fluid passageway.

Abstract: A non-electrically driven enteral feeding pump including an expandable elastomeric bladder is provided. The enteral feeding pump includes a fluid delivery tube. The fluid delivery tube controls flow rate of fluid from the pump. The present invention further describes an enteral feeding pump assembly including the portable enteral feeding pump and a peristaltic pump. The peristaltic pump can be configured to be operatively coupled to the elastomeric bladder of the enteral feeding pump for transferring fluid from a reservoir external to the elastomeric bladder into a chamber of the elastomeric bladder.

Abstract: Provided herein are dental adhesives that contain a dental adhesive material and a multifunctional magnetic platform. The multifunctional magnetic platform has a core-shell structure. The core includes magnetic microparticles and an antibiotic with the core capped by an antibacterial silane coating. Also provided are methods utilizing the dental adhesives for increasing longevity of a dental restoration and for restoring a tooth in a subject.

Abstract: The present invention relates to dental, light-curable, one-component composite compositions comprising (A) monomers, (B) fillers, and (C) initiators, the viscosity ?20 of which at 20° C. is greater than 400 Pa*s, preferably greater than 800 Pa*s and more preferably greater than 1200 Pa*s, and the viscosity ?50 of which at 50° C. is less than 150 Pa*s, preferably less than 120 Pa*s and more preferably less than 90 Pa*s, and wherein the quotient ?50/?20 of the viscosity of the composite composition at 50° C. and the viscosity of the composite composition at 20° C. is less than 0.125, preferably less than 0.1. The invention is preferably directed to dental composite compositions selected from the group consisting of dental filling materials, lining materials, luting materials and fissure sealants.

Abstract: The present invention is a dermal-exfoliation system that uses positive pressure to deliver salt and/or bio-inert crystalline particle abrasives or saline solution to the stratum corneum, combined with a minimal amount of negative pressure to close the loop when in contact with the skin to evacuate spent particles and dislodged skin cells and debris. An applicator handpiece is optimized for the use of the combined pressure system discussed herein for the removal of epidermal layers.

Abstract: The invention includes saponin-containing compositions, wipes impregnated with these compositions, and related methods. Specifically, the invention includes a cleansing and deodorizing composition that includes a saponin; a deodorizer; cyclodextrin and a solvent. The saponin may be derived from botanical sources, such as, for example, Sapindus mukorossi or trifoliatus. Also included are textiles that are impregnated with the composition of the invention. Such textiles may be, for example, made of biodegradable materials. The invention also includes related methods of use and treatment.

Abstract: A therapeutic skin mask having: an elastomeric film barrier layer, and a pressure sensitive adhesive (PSA) disposed on a first side of the elastomeric film barrier layer, the PSA having a therapeutic ingredient configured to treat an area of skin upon which the PSA is applied; wherein the elastomeric film barrier layer includes a shape configured to cover the area of skin.

Abstract: A spherulite concentrate combining water, a linear alkyl sulfate surfactant, and specific amphoteric surfactants. The concentrate can be used in a skin care composition, where the skin care composition contains the concentrate in an amount between, e.g., 70% and 99% by weight of the composition, cosmetically acceptable oils, and a pH adjuster. The skin care compositions may be present in packaging, which may contain one or more skin care compositions described herein.

Abstract: An aqueous microcapsule dispersion liquid containing a component (A) and a component (B), component (A): microcapsules having a shell comprising an inorganic material as a constitutional component, and a core including one or more of an organic compound, inside the shell, and component (B): a polysaccharide containing a cationically modified branched chain structure. A content of the component (B) per 100 parts by mass of the component (A) in the aqueous microcapsule dispersion liquid is 0.03 part by mass or more and 3 parts by mass or less.

Abstract: An oral care composition with a tin, polyol with five or six carbon atoms, polyol with seven or more hydroxyl functional groups, and a pH of greater than 7. An oral care composition with a tin ion source, a fluoride ion source, a polyol with five or six carbon atoms, a non reducing sugar or sugar alcohol with seven or more hydroxyl functional groups, and a pH of greater than 7. Oral care compositions with a high tin ion availability.

Abstract: A composition of matter that may be used as an eyebrow primer, and a method for using the composition of matter, are provided. The composition of matter may include at least 5% by weight of a transparent filler, a polyacrylamide thickener, at least 2% by weight of one or more high HLB surfactants, and a water-dispersed latex polymer. The composition of matter may be substantially free of oils.

Abstract: A cosmetic aerosol product comprising a pressurised container holding a base composition and a propellant which is a mixture of a compressed gas and a liquefied gas at a weight ratio of from 0.1: 99.9 to 10: 90; wherein the pressurised container comprises: i). a pressure release valve; ii). a reservoir containing the base composition and the propellant; and iii). a dip tube arranged for the transport of the base composition from the reservoir to the pressure release valve; wherein the base composition comprises a suspension of a particulate solid cosmetic active in a carrier oil, the particulate solid cosmetic active having a concentration of from 5 to 40% by weight in the base composition.

Abstract: A cosmetic aerosol product comprising a pressurised container holding a base composition and a propellant which is a mixture of a compressed gas and a liquefied gas at a weight ratio of from 0.1:99.9 to 10:90; wherein the pressurised container comprises: i). a pressure release valve; ii). a reservoir containing the base composition and the propellant; and iii). a dip tube arranged for the transport of the base composition from the reservoir to the pressure release valve; wherein the base composition comprises ethanol and a non-volatile, ethanol-soluble cosmetic active and the weight ratio of the base composition to the propellant is from 30:70 to 90:10.

Abstract: A skin penetration cosmetic material containing (A) a low-molecular-weight betaine, (B) a multivalent alcohol, (C) a skin condition improving ingredient, and (D) water.

Abstract: The invention relates to a cosmetic process for depigmenting, lightening and/or whitening keratin materials, in particular the skin, which comprises the application of a cosmetic composition comprising a compound of formula (I): or its tautomer form of formula (I?): in which: R1 and R2, which may be identical or different, denote a radical chosen from: a) a hydrogen atom; b) a C1-C20 alkyl group optionally interrupted with N, S or O, optionally substituted with one or more group(s) chosen from —OR3, —SR3, —NR3R4, —CONHR3; —COOR3; and an aryl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; c) a C1-C8 alkyl group substituted with a C5-C12 aryl radical optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; d) a phenyl group optionally substituted with one or more hydroxyls and/or with one or more C1-C8 alkoxy radicals; R3 denoting H or a C1-C5 alkyl group, R4 denoting H, a C1-C5 hydrocarbon-based

Abstract: Personal care compositions, such as solid personal care compositions, and methods for preventing and/or treating skin pollution or lipid peroxidation of skin are disclosed. The personal care compositions may include a carrier and an antioxidant system. The antioxidant system may include one or more antioxidants and may be present in an effective amount to treat, inhibit, or prevent a lipid peroxidation of skin.

Abstract: A hair conditioning formulation is provided, comprising: a dermatologically acceptable vehicle; and a conditioning polymer, wherein the conditioning polymer is a dextran polymer functionalized with tertiary amine groups; wherein the dextran polymer has a weight average molecular weight of 50,000 to 3,000,000 Daltons.

Abstract: The invention relates to the use of sulfonate-functionalized alkyl polyglucosides and other functionalized alkyl polyglucosides surfactants in oral care applications such as toothpaste and mouthwash. These surfactants have desired performance attributes while not displaying the potential to cause oral or gingival irritation neither as a 4% solution, nor as a neat product.

Abstract: Proposed is a composition having antibacterial or antifungal activity, which includes a fermented extract of Scutellaria baicalensis, a fermented extract of Salvia miltiorrhiza, and a fermented extract of Dryopteris crassirhizoma, which, being comprised of natural ingredients, is safe for the human body, and can be effectively used as a natural preservative for foods and cosmetics due to its excellent antibacterial activity.

Abstract: The present disclosure is related to a method of treating and concealing a skin defect in a subject. The method comprises applying a makeup composition to the skin defect, wherein the makeup composition comprises silicone and/or a purified natural remedy and a coloring agent, wherein the makeup composition simultaneously conceals and treats said skin defect. Makeup compositions and kits for treating and concealing skin defects are also disclosed.

Abstract: A composition includes a salt; a polymer; and an antioxidant. A dispenser includes a flexible container having a closed end and an opposed open end; an osmotically-effective solute composition encapsulating at least a portion of the container, the solute composition including antioxidant in an amount of at least 0.5 wt %, based on weight of the solute composition; a semipermeable membrane encapsulating the osmotically-effective solute composition; a cap having a sealing surface adapted for sealing engagement with the open end of the container; and a port extending from an interior of the container and through the cap. Also disclosed are methods of making and using the composition and osmotic pumps.

Abstract: A cell encapsulating implantable device, including: a cell chamber accommodating a plurality of biological cells disposed within a fluid, the cell chamber at least partially enclosed within an immuno-isolative membrane which permits diffusive exchange of nutrients between the fluid and a tissue in which the device is implanted for sustaining the plurality of biological cells, and the cell chamber being configured to accommodate flow of fluid therethrough.

Abstract: Disclosed is a dry powder oral formulation that includes an active pharmaceutical ingredient (API), a lecithin powder, a galactomannan, one or more sweetening agents, one or more flavoring agents and an organic acid in a pharmaceutically acceptable preparation. Also disclosed are an excipient composition in absence of an API and methods of making and using the formulations and compositions. Also disclosed is a chewable, swallowable, and/or orally disintegrating tablet comprising an API, a lecithin powder, a galactomannan, one or more sweetening agents, one or more flavoring agents and an organic acid in a pharmaceutically acceptable preparation.

Abstract: Disclosed is a metal peroxide composite injectable hydrogel, a preparation method and use thereof. The preparation method comprises the step of dissolving a modified high-molecular polymer, a metal peroxide and a peroxidase in a solvent, mixing evenly, and standing to prepare the hydrogel, wherein the modified high-molecular polymer is a high-molecular polymer grafted with a phenolic hydroxyl group. According to the invention, the metal peroxide induces the modified high-molecular polymer to be quickly crosslinked under an action of the peroxidase to prepare the hydrogel, and the prepared hydrogel has good photo-thermal performance, antibacterial property, tissue adhesion, osteogenesis promoting effect, shape adaptability and injectability, can be well adapted to an irregular bone defect area, and is used for repairing a postoperative defect of tumor through a synergistic effect of multiple functions, which can effectively prevent tumor recurrence and reduce a possibility of implant material infection.

Abstract: The present invention refers to hyaluronic acid crosslinked with polyglycerol polyglycidyl ether containing local anesthetic agents, to a process for its preparation and its use in therapy, cosmetics and as a carrier.

Abstract: The present invention relates to pharmaceutical compositions comprising 3-(4-amino-1-oxo-1, 3 dihydro-isoindol-2-yl)-piperidine-2, 6-dione dissolved in a liquid vehicle. The present invention also relates to pharmaceutical compositions comprising 3-(4-amino-1-oxo-1, 3 dihydro-isoindol-2-yl)-piperidine-2, 6-dione and one or more pharmaceutically acceptable excipients. The present invention also related to the process for preparing the said liquid composition and its use for treating multiple myeloma and lymphoma.

Abstract: A composition comprises a low-solubility ingredient having a particle size of at most 10 ?m dispersed in a solvent. The ingredient is present in an amount greater than the saturation limit of the ingredient in the solvent. The composition passes the freeze-thaw cycling test.

Abstract: A composition for the transport of a dissolved active agent into hair follicles is provided that includes an active agent dissolved in a topical dispersion medium, and submicron particles. In one aspect, a pharmaceutical composition is provided for use in transporting a dissolved pharmacologically active therapeutical and/or prophylactic agent into hair follicles including a pharmacologically active therapeutic and/or prophylactic agent dissolved in a topical dispersion medium, and submicron particles. In embodiments, the active agent is not chemically coupled to the submicron particles. In a further aspect, the composition is a cosmetic composition including a cosmetically active agent, and the cosmetic composition can be used in a cosmetic method, in which the cosmetic composition is applied to an area of skin with hair follicles.

Abstract: The present invention relates to a carbon dioxide-generating micelle. In the present invention, a micelle which uses a material with high biocompatibility and has a multi-arm structure capable of generating a large amount of carbon dioxide is produced, and thus, a greater amount of carbon dioxide can be generated, as compared to conventional polyethylene glycol-based micelles. In addition, in the present invention, intracellular penetration is improved by using a ligand (peptide), and thus, it is possible to target adipocytes and minimize effects on surrounding tissues and cells. The carbon dioxide-generating micelle according to the present invention can be produced as an injectable preparation, and can be applied to local lipolysis supplements or diet and beauty products that break down localized fat.

Abstract: Micellar particles formed of a plurality of block copolymers, compositions comprising same, copolymers used to form the particles, and polymeric aggregates formed therefrom are provided. The micellar particles are for use in the treatment of inflammation, including chronic inflammation. The block copolymers forming the particles include at least a first block and a second block. The first block has an anti-inflammatory agent covalently attached, directly or via a linking moiety or group, to at least a portion of its backbone units; and the second block has a hydrophilic moiety that comprises an amino acid sequence that is capable of interacting with an inflammatory biomarker covalently attached to at least a portion of its backbone units, and the particle features a core made of the first block and a hydrophilic shell made of the second block.

Abstract: Lipid nanoparticles (LNPs) comprising biologically active poly nucleotides (e.g., RNAs) are provided. In some aspects, the LNP complexes are provided as aerosols and/or dry powders, such as for delivery to the lungs. Method of making and using such compositions are provided.

Abstract: The present disclosure relates to a lipid compound of formula (Ia) or (AL-GI): having various cleavable linkers defined by the variables Z1 and Z2 and Z10 and Z20. The present disclosure also relates to a lipid carrier or lipid nanoformulation employing the lipid compound, and the use of the lipid compound in a pharmaceutical composition as well as for a method of delivering an effector, e.g., a therapeutic agent.

Abstract: The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof.

Abstract: A method and process for creating an electrolyte based liposome powder. The process involves dissolving electrolyte rich salts in water, adding in various concentrations, emulsifiers such as maltodextrines and gum acacia, adding essential oils, mixing and homogenizing to specified levels, heating and cooling for defined times and to desired temperatures, all to create a liposome with an electrolyte core and an oil based lipid. Then drying through specified processes to create a liposome powder that can be used in water as a soak bath, in water as an electrolyte replacement drink, in oils for a liposome electrolyte cream, and in gelatins for an electrolyte edible gummy.

Abstract: The present invention concerns pharmaceutical formulations of ARN-509, which can be administered to a mammal, in particular a human, suffering from an androgen receptor (AR)-related disease or condition, in particular cancer, more in particular prostate cancer, including but not limited to castration-resistant prostate cancer, metastatic castration resistant prostate cancer, chemotherapy-naive metastatic castration resistant prostate cancer, biochemically relapsed hormone sensitive prostate cancer, or high-risk, non-metastatic castration-resistant prostate cancer. In one aspect, these formulations comprise a solid dispersion of ARN-509 and a poly(meth)acrylate copolymer. In one aspect, the solid dispersion of ARN-509 and a poly(meth)acrylate copolymer is obtainable, in particular is obtained, by melt-extruding a mixture comprising ARN-509 and a poly(meth)acrylate copolymer and optionally subsequently milling said melt-extruded mixture.

Abstract: A sustained release composition comprising one or more particles comprising a polymer and an amount of a select androgen receptor modulator (SARM), and methods of making and using the composition, are provided.

Abstract: The present disclosure relates to pharmaceutical compositions comprising an intragranular phase, wherein the intragranular phase comprises: (i) an amorphous solid dispersion comprising Compound (I) or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable polymer, and (ii) a surfactant; and an extragranular phase, wherein the extragranular phase comprises a surfactant. The present disclosure also relates to methods of using said compositions in the treatment of various disorders.