Abstract: Techniques for fluid delivery are provided. In some embodiments, the techniques may involve monitoring a value representative of a physiological condition in a body of a user. The techniques may further involve operating in a first operational mode of a fluid delivery device based on the value representative of the physiological condition. The techniques may further involve transitioning to a second operational mode of the fluid delivery device based at least in part on the value representative of the physiological condition relative to a threshold and a time that has been spent in the first operational mode of the fluid delivery device.

Abstract: A system and method for operating an analgesia administration system is disclosed. A control device is associated with a drug delivery device and configured to receive a first user input including at least a portion of a fingerprint of a patient, together with a second user input corresponding to a request to administer medication. The portion of the fingerprint is compared with previously-stored fingerprints to determine an identity of the patient and, in response to receiving the second user input and determining that the patient is an authorized user, one or more sensors are used to obtain one or more signals indicative of a state of the patient. If the state of the patient satisfies a set of medication delivery criteria, the drug delivery device is caused to administer a predefined amount of medication to the patient.

Abstract: The exemplary embodiments attempt to identify impending hypoglycemia and/or hyperglycemia and take measures to prevent the hypoglycemia or hyperglycemia. Exemplary embodiments may provide a drug delivery system for delivering insulin and glucagon as needed by a user of the drug delivery system. The drug delivery system may deploy a control system that controls the automated delivery of insulin and glucagon to a patient by the drug delivery system. The control system seeks among other goals to avoid the user experiencing hypoglycemia or hyperglycemia. The control system may employ a clinical decision support algorithm as is described below to control delivery of insulin and glucagon to reduce the risk of hypoglycemia or hyperglycemia and to provide alerts to the user when needed. The control system assesses whether the drug delivery system can respond enough to avoid hypoglycemia or hyperglycemia and generates alerts when manual action is needed to avoid hypoglycemia or hyperglycemia.

Abstract: An electro-pneumatic intelligent syringe includes an injection assembly including a fixing component and a moving component, and a pneumatic assembly including an airway component and a pneumatic component. The electro-pneumatic intelligent syringe can operate intelligently and automatically, which provides equipment support for achieving automatic injection.

Abstract: The present invention relates to an autoinjector device (10) for use in combination with a syringe (30), said syringe comprising a movable plunger; a needle; and a tubular needle shield (34). The claimed autoinjector device (10) comprises: an elongated housing having a proximal (11) and a distal end (12); a drive mechanism; a syringe holder (40) in order to support the fragile syringe and to prevent damage to the syringe. The invention furthermore relates to a method for assembly of the autoinjector device according to the invention.

Abstract: The application describes syringe carriers for medicament delivery devices such as autoinjectors. Methods of assembly are described, including a method of assembling a sub-assembly of a medicament delivery device. The method includes the steps of providing a housing, a syringe carrier and a syringe, wherein the housing extends along a longitudinal axis from a proximal end to a distal end; inserting the syringe carrier into the housing so that the syringe carrier is aligned with the housing along the longitudinal axis and inserting the syringe into the syringe carrier in the longitudinal direction. The syringe carrier remains aligned with the longitudinal axis during insertion of the syringe into the syringe carrier. As the syringe is inserted into the syringe carrier, the syringe rotates from a first position parallel to the longitudinal axis to a second position that is not parallel to the longitudinal axis and then to a third position parallel to the longitudinal axis.

Abstract: An auto-injector for receiving and operating a syringe to facilitate injection of medicament into a subject, the auto-injector comprises an openable lid to allow insertion and removal of the syringe, a lid latch operable to latch the lid in a closed position, and a needle safety shroud moveable between a first retracted position and a second extended position. The auto-injector is configured such that, when the safety shroud is in the first position, the lid latch cannot be released preventing the lid from being opened and, when the safety shroud is in the second position, the lid latch can be released allowing the lid to be opened.

Abstract: An apparatus includes a housing, an energy storage member, a carrier, a medicament container, and a delivery control mechanism. The housing defines a gas chamber configured to receive pressurized gas from the energy storage member to pressurize the gas chamber. The carrier has a proximal surface that defines a portion of the gas chamber. The medicament container is coupled to the carrier and has a distal end portion coupled to a delivery member. The medicament container contains a medicament and includes an elastomeric member that seals the medicament within the medicament container. The delivery control mechanism is coupled to a proximal end portion of the medicament container and includes a flow restriction member for regulating a pressure supplied by the gas chamber and entering into the medicament container that acts on the elastomeric member.

Abstract: The application describes syringe carriers for medicament delivery devices such as autoinjectors. One example concerns a syringe carrier for a syringe with a flange, the syringe carrier having a tubular housing extending along a longitudinal axis from a proximal end to a distal end and a syringe holder attached to the distal end of the tubular housing, wherein the syringe holder is configured to hold the flange of the syringe, and wherein the syringe holder comprises either a c-clip or a screw thread. Other associated syringe carriers, sub-assemblies, medicament delivery devices and corresponding methods are also described.

Abstract: A cartridge for positioning within a pharmaceutical delivery device is described. The cartridge has a housing with a light pipe section which acts as a light pipe having an input location, and a light diffusing section optically coupled to the light pipe. The light diffusing section extends beyond a plane defined by the housing.

Abstract: A drive assembly for a drug delivery system includes a plunger member configured to engage and move a stopper within a container, with the plunger member having a first position and a second position axially spaced from the first position, a leadscrew configured to move the plunger member from the first position to the second position, and a biasing member configured to bias the leadscrew in a rotational direction, where rotational movement of the leadscrew is configured to move the plunger member from the first position to the second position.

Abstract: Diabetes management systems include an insulin delivery device and a monitoring device for detecting at least one characteristic relating to the insulin delivery device. Monitoring devices may comprise pen caps.

Abstract: Embodiments of the present disclosure are directed to conserving energy of an injection device that includes an energy source, an electronic component configured to be electrically decoupled from the energy source, a priming component configured to generate a trigger, and a mechanism attached to the priming component and configured to perform operations comprising in response to receiving the trigger, electrically coupling the energy source to the electronic component.

Abstract: The present disclosure relates to an acoustic signal generating device for a medical injection device. The acoustic signal generating device has a base body comprising a first resilient arm comprising a first free end; an abutment surface, and an impact surface. The first resilient arm is configured to be deflected by a first load being applied on the first resilient arm such that the first free end of the first resilient arm is in compressive engagement with the abutment surface, whereby when the first load is increased to a second load the first free end is released from compressive engagement with the abutment surface and the first resilient arm hits the impact surface, thereby generating an acoustic signal. Moreover, the present disclosure relates to a medical injection device comprising said acoustic signal generating device.

Abstract: A drug delivery device (100, 300) for delivering a plurality of doses of a medicament, wherein a needle shield (110, 310) is operationally coupled to a hub driving structure (210, 430), a active needle assembly (220, 420), a pulling structure (230, 320) and a support structure (136, 336, 338, 350) such that the operation of the needle shield is adapted to drive the active needle assembly (220, 420) to the proximal position of the active needle assembly (220, 420), before the needle shield (110, 310) can reach the proximal position of the needle shield (220, 420), whereby fluid connection can be establish before the drive mechanism can be activated.

Abstract: Embodiments of the present invention relate to a topical anesthetizing apparatus that includes a first portion, second portion, numbing orb that is configured to be chilled, an open state, and a closed state. The first portion includes a first recess. The second portion comprises a second recess. In the closed state, the first recess and the second recess come together to form a sphere. Here, the numbing orb is selectively positioned within the sphere. In the open state, the first recess is positioned distal to the second recess and the numbing orb is selectively positioned within the first recess or the second recess. The first portion is hinge attached to the second portion. Here, the numbing orb is configured to be topically applied to the skin of a mammal to thereby topically anesthetize the skin.

Abstract: The disclosure relates to a nebulizing device (2) for an inhalator (100). The nebulizing device (2) comprises an aperture plate (6) having a fluid side (7) to which a fluid (110) is to be supplied and a nebulizing side (9) at which the fluid is to be nebulized, wherein the aperture plate (6) comprises a single layer (5) of unitary material, a plurality of recesses (10) being formed in the single layer (5), the recesses (10) each having an opening (11) facing the fluid side (7) and a bottom (12) facing the nebulizing side (9), a plurality of the apertures (20) being formed in the bottom (12) of each of the recesses (20).

Abstract: An atomizer includes a medicament feeding unit, a medicament delivering vessel, and an atomizing unit, the medicament delivering vessel includes a medicament guiding tube communicated to the medicament feeding unit, and an elastic membrane bladder wound around the medicament guiding tube, wherein when medicament liquid is fed into the medicament delivering vessel through the medicament feeding unit, the elastic membrane bladder is inflated and is capable of generating an elastic driving force for driving the medicament liquid to be fed towards the atomizing unit for atomizing the medicament liquid. A depressurization receptacle has a curved medicament delivery passage is also provided for causing pressure loss of the medicament liquid.

Abstract: An inhalation device equipped with a liquid storage section storing a liquid that generates an aerosol when heated, a heating section that heats the liquid, an electric power supply section that stores electric power, and a control section that controls the electric power supply from the electric power supply section to the heating section, wherein: when predetermined conditions determined in advance are satisfied, the control section controls the electric power supply to perform first heating to raise the temperature of the liquid to a first temperature, at which the liquid vaporizes, or higher; and when an event that is expected to cause the predetermined conditions to be satisfied is detected before the predetermined conditions are satisfied, the control section controls the electric power supply to perform second heating to make the temperature of the liquid to be a second heating temperature or higher but lower than the first temperature.

Abstract: A medical system can include a medical gas duct comprising a first end, a second end opposite the first end, a first opening at the first end of the duct, and a second opening at the second end of the duct. The first opening can be positioned to receive medical gas exiting an exhaust port of a medical gas evacuation unit. On the condition a medical suction supply provides a suction at the second opening of the duct, medical gas exiting the exhaust port of the medical gas evacuation unit flows into the first opening of the duct. Devices, systems, and methods relate to evacuating medical gasses.

Abstract: The method includes establishing an aerosol-generating device with an electric heating element, and configuring a porous body and a liquid retention medium within an aerosol-generating article, a first end of the aerosol-generating article being formed in part by the porous body, the porous body being configured to absorb heat from the electric heating element and emit at least some of the absorbed heat into an airflow that is drawn into the first end and through a second end of the aerosol-generating article, the liquid retention medium being between the first end and the second end, the aerosol-generating article being selectively connectable to the aerosol-generating device, the electric heating element being in direct contact with the porous body when the aerosol-generating article is connected to the aerosol-generating device.

Abstract: [Problem] To provide a drug inhaler equipped with a counter mechanism having a simple and compact configuration. [Solution] In this inhaler 100, a mount is gradually peeled off one or a plurality of blister strips in coordination with the operation of a blister opening means, and an amount of a powdered drug corresponding to a single dose is sequentially fed to a space enabling inhalation through an inhalation port 41. The inhaler 100 has a counter mechanism for presenting the remaining number of the drug that is individually packaged by the blister strip in coordination with the operation of the blister opening means.

Abstract: Provided herein are dry powder formulations comprising at least one active pharmaceutical ingredient suitable for nasal application. Also provided are unit dose forms and devices comprising such formulations and methods of using such formulations for the treatment of various conditions including respiratory conditions, hemodynamic collapse, seizures, migraines, and other conditions.

Abstract: A process for flushing a gas measurement line of a medical device includes the steps of: providing a first flushing volume flow to purge the gas sensing line toward a patient during a first time interval, and interrupting the first flushing volume flow during a second time interval. Further disclosed are a corresponding apparatus, a medical device, a computer program product with a computer readable medium.

Abstract: A respiratory treatment device having an inlet configured to receive exhaled air into the device, an outlet configured to permit exhaled air to exit the device, a valve moveable in response to a threshold exhalation pressure at the inlet between a closed position where the flow of air from the inlet to the outlet is restricted, and an open exhalation position where the flow of air from the inlet to the outlet is less restricted, and a valve brace configured to support the valve, wherein a position of the valve brace relative to the valve is selectively adjustable to increase or decrease the threshold exhalation pressure.

Abstract: An interface for positive pressure therapy includes a mask assembly, a headgear assembly and a connection port assembly. The mask assembly comprises a seal member that has an upper portion movably connected to an integrated lower portion, wherein the upper portion rolls during hinging movement of the upper portion relative to the lower portion. The headgear assembly allows connection to the mask assembly in a direction substantially normal to a direction of strap tension. The connection port assembly includes a swivel elbow with a valve member that controls flow through a port that opens toward the user.

Abstract: A patient interface comprises a blower, a cushion for contacting a user's face, and a mask body and/or a frame for supporting the cushion on a user's face. The cushion and/or the mask body or frame define an interior space for receiving a flow of gases from the blower. The blower is mounted to the mask body or frame so that the blower is at least partially within the mask body or frame. The blower substantially separates a high pressure side of the mask body or frame from a low pressure side of the mask body or frame and/or the mask body or frame is substantially without a wall between the blower and the interior space.

Abstract: Proposed are a 3G sensor mask and a continuous positive airway pressure system using same, the mask sensing the sleep position of a patient during sleep to immediately correct pressure through a blower according to a changed sleep position if the sleep position has changed, and the system comprising: a 3G sensor mask worn on the face of a patient to sense the sleep position of the patient during sleep; and a positive airway pressure machine, which is connected to the 3G sensor mask in a wired/wireless manner to receive sleep position information about the patient sensed through the 3G sensor mask, detects the respiratory obstruction pressure necessary for an airway opening in response to a received sleep position change of the patient, and immediately corrects treatment pressure on the basis of the detected respiratory obstruction pressure for each sleep position.

Abstract: The invention comprises a method of operating a breathing apparatus comprising measuring a baseline breath flow parameter being respiratory rate and/or tidal volume or a parameter derived therefrom, varying the flow rate provided by the breathing apparatus, measuring a current breath flow parameter being respiratory rate and/or tidal volume or a parameter derived therefrom, comparing the baseline and current breath flow parameters, and altering operation of the breathing apparatus based on the comparison. The invention also comprises a breathing apparatus that implements the above method.

Abstract: A fluid passage/stop body, component, housing and apparatus, a ventilation treatment device, and an oxygen supply control method. The fluid passage/stop body comprises a sliding plate and a flexible connecting member; the flexible connecting member is connected to the sliding plate; the flexible connecting member is used for connecting to a first channel wall of a first fluid channel of a fluid passage/stop apparatus; and the sliding plate is used for moving, driven by the pressure of a fluid in the first fluid channel, to drive the flexible connecting member to flexibly deform. The fluid passage/stop body is simple in structure, can drive, in actual use, a passage/stop member to safely and reliably achieve the passage/stop of a fluid, and can significantly improve, in a ventilation treatment device, the safety of oxygen supply of the ventilation treatment device.

Abstract: A method for determining a respiratory-gas content in a respiratory tract, which content is present in the respiratory tract of an at least partially artificially ventilated patient following a plurality of breaths performed with the involvement of a ventilation apparatus, wherein the plurality of breaths include at least one earlier number of breaths and at least one follow-up breath following the earlier number of breaths; wherein the earlier number of breaths include an earlier breath or a plurality of successive earlier breaths; wherein the method comprises quantitative detection of inspiratory and expiratory respiratory-gas flows by at least one respiratory-gas flow sensor and summation of detected inspiratory and expiratory flow values to form the respiratory-gas content in the respiratory tract; wherein a respiratory tract content starting value, at which the determination of the respiratory-gas content in the respiratory tract for the follow-up breath starts, depending on a difference in respiratory-g

Abstract: A respiratory apparatus that is configured to provide a flow of gases to a user for respiratory therapy. A flow generator is operable to generate a flow of gases. A controller is operable to control one or more properties of the flow of gases provided to the user by controlling a motor speed of the flow generator. The controller is configured to receive one or more input therapy settings that represents one or more properties desired for the generated flow of gases during a therapy session. The controller predicts if a steady-state temperature of the apparatus will exceed a high-temperature-condition threshold, based at least partly on input therapy setting(s) and a heat model of the apparatus. The controller may generate an alarm and/or initiate an alarm response counteraction control measure in response to the prediction to reduce the risk of the apparatus exceeding the high-temperature-condition threshold.

Abstract: An obturator (2) for a tracheostomy tube (1) has a shaft (20) with a bullet-shape nose (24) at its patient end and a clip (21) at its machine end with arms (34) engaging recesses (15) on a coupling (13) at the machine end of the tube (1). The clip (21) is rotatably mounted with the shaft (20) by means of an engaging spigot (135) and aperture (213) and is retained angularly by dimples (219) on the clip engaged with recesses (141) on the obturator shaft. The obturator (2) is released from the tube (1) by twisting the clip against the retention of the dimples with the recesses and without applying any twisting force to the patient end of the obturator or tube.

Abstract: A tube 174 for delivery of gases to a patient interface and for treatment of expiratory gases. The tube has an inspiratory conduit 170 for directing a flow of gas toward a patient interface, an expiratory conduit 173 for directing a flow of gas from the patient interface 100 and a filter 140 in fluid communication with, or part of, the expiratory conduit 140. The filter 140 is configured to filter the flow of expiratory gases from the patent interface 100 before passage of the flow of expiratory gases from the patient interface into ambient air.

Abstract: There is provided a respiratory gas delivery and sampling system, a gas sampling system, a gas sampling interface and a gas sampling tip that may be used to sample exhaled and/or expired gases from a patient, particularly from a patient who is apnoeic and/or who is receiving high flow respiratory therapy. The gas sampling system comprises a respiratory gas monitor in fluid communication with the gas sampling interface, which comprises the gas sampling tip of the invention. The gas sampling interface comprises a gas sampling conduit and the gas sampling tip is located at a free end of the conduit. The gas sampling interface may be configured to allow the gas sampling tip to be selectively positioned at or in the mouth or a nare of the patient's nose.

Abstract: An electrically conductive plastic (ECP) material can be used to heat water in a reservoir of a respiratory humidifier to encourage heating and/or humidification of gases passing through the respiratory humidifier. The electrically conductive plastic material can at least in part overmould the base and/or walls of the chamber and/or the reservoir of the respiratory humidifier. The reservoir can also partially or fully be formed from the electrically conductive plastic material. Furthermore, the humidification system can be configured to create substantially equal or differential heating of water in the reservoir.

Abstract: Apparatus for providing a mixture including nitrous oxide (N2O) to a subject are disclosed. One apparatus includes a first reservoir for storing a first gas including at least N2O and a mask connected to the first reservoir in which the mask includes a second reservoir integrated with the mask. The second reservoir is for storing a first additive and the mask is for combining the first gas and the first additive to create a mixture including at least the N2O and the first additive in the mask and introducing the mixture to the mouth and/or nose of a subject. Another apparatus includes a configuration including separate first and second reservoirs storing at least N2O and a first additive in which the first reservoir and/or the second reservoir are detachably connected to the mask.

Abstract: A humidifier for humidifying a flow of pressurized breathable gas to be delivered to a patient includes a dock with a device compartment configured to at least partially removably receive in a vertical direction an RPT device that is configured to supply the flow of pressurized breathable gas, and a humidification compartment fluidly connected to the device compartment, the humidification department being configured to at least partially removably receive in a vertical direction a humidification tub configured to contain a supply of water. The dock is structured to convey the flow of pressurized breathable gas through the dock from the device compartment to the humidification compartment.

Abstract: A respiratory treatment device having an inlet configured to receive exhaled air into the device and an outlet configured to permit exhaled air to exit the device. A blocking member is moveable between a closed position where the flow of air through the device is restricted, and an open position where the flow of air through the device is less restricted. A biasing member is configured to bias the blocking member toward the closed position, wherein a level of bias decreases as the blocking member moves from the closed position to the open position.

Abstract: A vent system for use during respiratory therapy with a flow of pressurized gas may provide a continuous vent flow of gas. The vent system may include a vent housing having an outer wall; an inner wall, the inner wall defining an inlet for the flow of gas; and a base positioned between the outer wall and the inner wall, the base having at least one first orifice and at least one second orifice. The vent system may include a membrane, the membrane being shaped and dimensioned such that the membrane does not cover the at least one first orifice to allow the vent flow through the at least one first orifice, and the membrane being shaped and dimensioned such that in a first position the membrane is positioned over the at least one second orifice to allow the vent flow through the at least one second orifice.

Abstract: A method for the prevention and/or treatment of post-operative cognitive dysfunction, which entails administering to a human or other mammal an effective amount of one or more compounds selected from the group consisting of N-substituted 2(1H) pyridones, N-substituted 3(1H) pyridones and pharmaceutically-acceptable salts of any one or more of the above pyridones, which are optionally further substituted at various available ring positions.

Abstract: A device for promoting healthy sleep habits in an individual, including a recording device for capturing the voices of the individual's parent(s) or care giver, a processing unit for analyzing the recorded voices and creating a customized soothing method for the individual, and a speaker for playing the customized soothing method. The device also includes a mechanism for gradually adjusting the soothing method over time to train the individual for healthy sleep practices.

Abstract: Disclosing a catheter, comprising a tubular elongated body. The tubular elongated body extends along a longitudinal axis between a proximal end and a distal end. The tubular elongated body has a lumen. At least a portion of the tubular elongated body is defined by a first coil. The first coil comprises a plurality of windings extending along and around the longitudinal axis. The first coil comprises at least one first region arranged near the distal end of the tubular elongated body and including a plurality of adjacent windings. The first region has a plurality of windings inserted from at least one second coil therein. The inserted windings of the second coil are positioned between the windings of the first coil; and the first coil further comprises at least one second region including a plurality of adjacent windings. The second region does not have windings inserted from the second coil.

Abstract: The disclosure is directed to a catheter system comprising an inner catheter and/or an outer catheter configured to at least partially receive the inner catheter. In some embodiments, the inner catheter comprises a proximal hub, a distal portion, and/or a pusher wire extending between the proximal hub and the distal portion. In some embodiments, the inner and/or the outer catheter does not include a smooth inner surface. In some embodiments, the inner and/or outer catheter includes an inner surface comprising a series of recessed surfaces. In some embodiments, the recessed surfaces are formed by the spaces between the catheter's reinforcement structure, where the spaces are filled and/or sealed by an encasement sleeve. In some embodiments, the reinforcement structure forms support surfaces for structures traversing through the inner diameter. In some embodiments, at least a portion of the support surfaces and/or recessed surfaces include reflown polymer and/or a hydrophilic coating.

Abstract: An elongated medical body having a resistance that is constantly 10 gf or less when a tube is moved 100 times while the elongated medical body is clamped at 500 gf between a pair of abutting members.

Abstract: A catheter includes an outward protruding portion provided at a distalmost end portion and protruding outward in a radial direction; and an inward protruding portion provided at the distalmost end portion and protruding inward in the radial direction.

Abstract: A urinary catheter conveying device includes a sleeve member, a conveying assembly and a controller. The sleeve member is for sleeving onto a glans of a penis and has a guiding hole to be registered with an external urethral orifice of the glans. The conveying assembly includes a casing removably mounted to the sleeve member, and a conveying mechanism for advancing the urinary catheter to the guiding hole such that the urinary catheter is inserted into the external urethral orifice. The controller controls the conveying mechanism to advance the urinary catheter to the guiding hole. A urinary catheterization system and a method of using the urinary catheterization system are also disclosed.

Abstract: Everting balloon systems and methods for using the same with an alignment element for stability and anti-rotation of the everting balloon are disclosed herein. The systems can be configured to access and deliver instruments, media, or other catheters into bodily lumens and cavities. The alignment element eliminates the potential for the everting membrane to become twisted or rotated which could impact access or the ability of the system to deliver materials. A compliance member facilitates internal pressurization of the everting catheter system.

Abstract: Disclosed herein are devices, systems, and methods relating to steerable catheters. A steerable catheter includes a first actuation line, an inner catheter, and an outer catheter. The inner catheter has an inner catheter proximal end, an inner catheter distal end, an inner catheter outer surface defining a keyway that is longitudinally-extending, and an inner catheter inner surface defining an inner catheter lumen. The outer catheter has an outer catheter proximal end, an outer catheter distal end, an outer catheter outer surface, and an outer catheter inner surface defining an outer catheter lumen and a spline that is longitudinally-extending and that projects radially inward into the outer catheter lumen. The outer catheter lumen is operable to receive the inner catheter with the spline of the outer catheter operable to key with the keyway of the inner catheter. The spline defines a spline lumen operable to receive the first actuation line.

Abstract: A launching catheter for targeting a second vessel from a first vessel includes a catheter including a proximal portion and a distal portion including a needle aperture and a flat rectangular radiopaque marker. The flat rectangular radiopaque marker disappears under fluoroscopy upon rotation to provide information about rotational alignment of the launching catheter. The launching catheter includes a needle configured to extend through the needle aperture. A method of aligning the catheter includes rotating the catheter in a first blood vessel until the marker has a thickness (e.g., minimal thickness) under fluoroscopy. The thickness indicates rotational alignment of the catheter.