Patents Issued in September 17, 2024
  • Patent number: 12091615
    Abstract: The present disclosure relates to an FCC catalyst composition and a process for preparing the same. In a first aspect, there is provided an FCC catalyst composition comprising 25 to 45 wt % Y-type zeolite, 20 to 40 wt % silicon oxide, 5 to 25 wt % alumina, 5 to 35 wt % of at least one clay and 0.5 to 3 wt % of at least one rare earth oxide. The weight % of each of the component is with respect to the total weight of the composition. The FCC catalyst composition has an average particle size in the range of 45-120?. In a second aspect, there is provided a process for preparing the FCC catalyst composition, which uses ball milled pseudoboehmite having an average particle size in the range of 1 to 8 micron and the whole process is carried out at a pH value in the range of 6 to 7.
    Type: Grant
    Filed: October 3, 2020
    Date of Patent: September 17, 2024
    Assignee: Reliance Industries Limited
    Inventors: Ravichandran Gopal, Nirav Jethalal Jani, Ankit Vipinkumar Patel, Asit Kumar Das
  • Patent number: 12091616
    Abstract: Process control parameters for production of hydrogen and FT products by steam/CO2 reforming include controlling steam reformer temperature, addition of steam, CO and optionally, biogas. Optimization of parameters have resulted in increased production of H2, removal of sulfur and halogen contaminants, and control of the H2/CO ratio for efficient generation of Fischer-Tropsch products.
    Type: Grant
    Filed: January 31, 2023
    Date of Patent: September 17, 2024
    Assignee: Raven SR, Inc.
    Inventor: Terry R. Galloway
  • Patent number: 12091617
    Abstract: A method may include: providing bio waste stream wherein the bio waste stream comprises at least one bio waste selected from the group consisting of palm oil mill effluent, soapstock, and combinations thereof; introducing the bio waste effluent stream into a fluidized catalytic cracking unit; contacting the bio waste with a catalyst in the fluidized catalytic cacking unit; and cracking at least a portion of the bio waste stream to form cracked products that comprise a cracked product stream.
    Type: Grant
    Filed: June 10, 2022
    Date of Patent: September 17, 2024
    Assignee: ExxonMobil Technology and Engineering Company
    Inventors: Xiaochun Xu, Dario Campani, Hyung Rae Kim
  • Patent number: 12091618
    Abstract: Mixtures of certain olefin-carboxylic acid copolymers (A) with at least one additive with detergent action, preferably at least one quaternary nitrogen compound (B), and optionally further fuel additives, are useful for improving or boosting the separation of water from fuel oils and gasoline fuels.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: September 17, 2024
    Assignee: BASF SE
    Inventors: Matthias Zorn, Harald Boehnke
  • Patent number: 12091619
    Abstract: A method for upgrading mixed pyrolysis oil may include contacting the mixed pyrolysis oil with hydrogen in the presence of a mixed metal oxide catalyst at reaction conditions to produce a reaction effluent including light aromatic compounds. The mixed pyrolysis oil includes multi-ring aromatic compounds and is formed from light pyrolysis oil and heavy pyrolysis oil at a ratio of 10:90 to 40:60 with light pyrolysis oil representing a bottom stream of a gas steam cracker and heavy pyrolysis oil representing a bottom stream of a naphtha steam cracker. The mixed metal oxide catalyst includes a plurality of catalyst particles with each catalyst particles including a plurality of metal oxides. An associated system for upgrading mixed pyrolysis oil may include a pyrolysis upgrading unit housing the mixed metal oxide catalyst and a separation unit operable to separate used mixed metal oxide catalyst from the reaction effluent.
    Type: Grant
    Filed: July 6, 2023
    Date of Patent: September 17, 2024
    Assignees: Saudi Arabian Oil Company, SABIC Global Technolgoies B.V.
    Inventors: Miao Sun, Sohel K Shaikh, Wojciech Andrzej Supronowicz, Chandrasekar Subramani, Eman Z Albaher
  • Patent number: 12091620
    Abstract: A system for processing plastic waste may include a feed line, a feed fractionator, a hydrotreater, a catalytic reforming unit, a heavy oil cracker, and a steam cracker. A pyrolyzed plastics feed is separated into light, medium, and heavy hydrocarbon streams. The hydrotreater removes sulfur, and the catalytic reforming unit produces a circular aromatic-rich stream. The heavy oil cracker generates cracked streams. The steam cracker produces a circular olefin stream from a cracked stream. A system for processing plastic waste may include the feed line, the feed fractionator, the hydrotreater, a medium hydrocarbon fractionator, the catalytic reforming unit, a full-range reforming unit, the heavy oil cracker, and the steam cracker. The medium hydrocarbon fractionator produces two hydrocarbon streams. The full-range naphtha reforming unit produces a second circular aromatic-rich stream.
    Type: Grant
    Filed: February 19, 2024
    Date of Patent: September 17, 2024
    Assignee: Chevron Phillips Chemical Company LP
    Inventors: Bruce D. Murray, Scott G. Morrison, Kenneth Fountain, Steven R. Horlacher, Vincent D. Mcgahee, Reza Khankal, David Dockter
  • Patent number: 12091621
    Abstract: A bio-multi-reactor hydrogen generation method using a bio-multi-reactor hydrogen generation system including a plurality of carbonization-water gasification furnaces and a plurality of heating furnaces arranged alternately side by side includes: arranging solid combustibles in each carbonization-water gasification furnace; dry distilling the solid combustibles by heating from each heating furnace adjacent to each carbonization-water gasification furnace; gasifying carbide obtained by dry distillation within each carbonization-water gasification furnace by supplying steam to the carbide to cause a water gasification reaction to take place; and maintaining each heating furnace at a temperature for dry distilling the solid combustibles in each carbonization-water gasification furnace by collecting a combustible gas generated in dry distillation of the solid combustibles in each carbonization-water gasification furnace in a tank and supplying the combustible gas to each heating furnace for combustion.
    Type: Grant
    Filed: September 28, 2023
    Date of Patent: September 17, 2024
    Inventor: Kozon Takahashi
  • Patent number: 12091622
    Abstract: The present invention relates to a fuel additive composition comprising at least a first additive chosen from quaternary ammonium salts different from betaines, and at least a second additive chosen from amido alkyl betaines, wherein the weight ratio of the amount of the first additive to the amount of the second additive is within the range of from 1:4 to 4:1. The invention also relates to an additive concentrate and to a fuel composition comprising this additive composition, and also to the use thereof for preventing and/or eliminating the deposits in at least one of the internal parts of an engine.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: September 17, 2024
    Assignee: TotalEnergies OneTech
    Inventor: Julien Sanson
  • Patent number: 12091623
    Abstract: A fuel additive composition comprising an anthocyanidin; an amino acid; and a catalyst. The anthocyanidin may comprise delphinidin chloride. The amino acid may comprise aspartic acid, leucine acid, glutamic acid, a non-natural amino acid, or a combination thereof. Embodiments of the present invention also relate to a method for making of fuel additive, the method comprising: providing an anthocyanidin; contacting the anthocyanidin with an amino acid to form an anthocyanidin-amino acid mixture; contacting the anthocyanidin-amino acid mixture with a catalyst. The method may further comprise contacting the anthocyanidin-amino acid mixture with ethanol and/or an acid. The method may further comprise adjusting the pH of the anthocyanidin-amino acid mixture to less than 7.
    Type: Grant
    Filed: September 29, 2023
    Date of Patent: September 17, 2024
    Inventor: Clifton Ray Taylor
  • Patent number: 12091624
    Abstract: A fuel stabilizer formulation includes a hybrid component that acts as an antioxidant, a chelating agent, and lubricant when added to the fuel, one or more vapor suppressants, and a water scavenger. Furthermore, the formulation may include components that bond with gasoline compounds to prevent evaporation of low-end components, form a layer along with the engine metal that prevents condensed water from corroding the metal, prevent corroded metal ions from destabilizing gasoline compounds into resin, and scavenge water to prevent water deposits at the bottom of the tank which limits biological activity, resulting in an overall improvement in oxidation stability over conventional fuel stabilizers.
    Type: Grant
    Filed: July 1, 2022
    Date of Patent: September 17, 2024
    Assignee: HAPPYFUEL, LLC
    Inventors: Shant Saroukhanian, Donato Polignone, Stephen Utschig-Samuels
  • Patent number: 12091625
    Abstract: This disclosure relates to CO2-philic crosslinked polyethylene glycol membranes useful for natural gas purification processes. Also provided are methods of using the membranes to remove CO2 and H2S from natural gas.
    Type: Grant
    Filed: June 13, 2023
    Date of Patent: September 17, 2024
    Assignee: Saudi Arabian Oil Company
    Inventors: Benjamin James Sundell, John Alden Lawrence, III, Seth A. Sharber, Sibo Lin, Daniel J. Harrigan
  • Patent number: 12091626
    Abstract: Processes for upgrading of a coal product and preparing of a purified coal product are provided. The process comprises the steps of: (i) providing a purified coal composition, wherein the composition is in the form of solid particles, and wherein at least about 90% by volume (% vol) of the solid particles are no greater than about 500 ?m in diameter; and (ii) combining the purified coal composition with a solid coal feedstock, in order to create a combined solid-solid blend upgraded coal product.
    Type: Grant
    Filed: September 7, 2022
    Date of Patent: September 17, 2024
    Assignee: ARQ IP Limited
    Inventors: Paul Groves, John Francis Unsworth
  • Patent number: 12091627
    Abstract: A method for producing a biofuel by continuous or discontinuous steam cracking of lignocellulosic biomass, comprises: —recording a digital model of the optimal steam cracking parameters as a function of the typology of the plant constituents of the biomass; —supplying the steam cracking reactor with heterogeneous biomass; —measuring at least once during the treatment the typology of the plant constituents of the biomass; and —controlling the adjustment of the steam cracking parameters as a function of the typology of the plant constituents of the measured biomass and of the digital model.
    Type: Grant
    Filed: June 17, 2020
    Date of Patent: September 17, 2024
    Assignee: EUROPEENNE DE BIOMASSE
    Inventors: Jean-Luc Despres, Thomas Habas, Adriana Quintero-Marquez, Frédéric Martel
  • Patent number: 12091628
    Abstract: The invention relates to a composition preparation method for preparing a composition of estolides, the method comprising reacting an unsaturated compound of a type such as an acid or ester, with a saturated fatty acid; in the presence of a catalyst of a type such as sulphonic acid, the said method including no vacuum distillation step thereby making it possible to separate the monoestolides from the polyestolides. The invention also relates to a composition of estolides that is obtainable by the method according to the invention and the use thereof in lubricating compositions.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: September 17, 2024
    Assignee: TOTALENERGIES ONETECH
    Inventors: Delphine Crozet, Alice Limoges, Laurent Germanaud, Henri Strub, Grégoire Hervé, Djibril Faye, Yves Travert
  • Patent number: 12091629
    Abstract: An aspect of the present invention provides a refrigerating machine oil containing an ester-based base oil, at least one epoxy compound selected from an alkyl glycidyl ether and an aryl glycidyl ether, and a phenol-based antioxidant, wherein a content of the epoxy compound is 0.7% by mass or more based on a total amount of the refrigerating machine oil, and the refrigerating machine oil is used with a refrigerant containing trifluoroiodomethane.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: September 17, 2024
    Assignee: ENEOS CORPORATION
    Inventors: Satoshi Nagai, Tatsuki Nakajima, Yuya Mizutani, Hidetoshi Ogata
  • Patent number: 12091630
    Abstract: A lubricating oil composition containing a base oil (A), a comb-shaped polymer (B), and an olefin-based copolymer (C), wherein a content of the component (B) is more than 0.80 mass % based on the total amount of the lubricating oil composition, a weight average molecular weight of the component (C) is 500,000 or more, and the lubricating oil composition has a viscosity index of 200 or more and a kinematic viscosity at 100° C. of 9.3 to 11.0 mm2/s.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: September 17, 2024
    Assignee: Idemitsu Kosan Co., Ltd.
    Inventor: Akinori Yomogita
  • Patent number: 12091631
    Abstract: A composition includes (a) a hydrocarbon fluid comprising less than 1000 ppm by weight of aromatics, a weight ratio normal paraffins/isoparaffins ranging from 0.2 to 1.0 and having an initial boiling point and a final boiling point in the range from 265° C. to 380° C., and (b) a copolymer derived from alpha-olefin monomers and vinyl acetate type monomers and optionally acrylate type monomers.
    Type: Grant
    Filed: June 9, 2021
    Date of Patent: September 17, 2024
    Assignee: TOTALENERGIES ONETECH
    Inventors: Didier Bedel, Clarisse Doucet, Frédéric Tort
  • Patent number: 12091632
    Abstract: A method of removing metal particles from a contaminated metalworking fluid comprising emulsion droplets and metal particles includes pressurizing a first clean metalworking fluid with gas to provide an aerated metalworking fluid; releasing the pressure of the aerated metalworking fluid to form a plurality of bubbles; applying a shear force to the contaminated metalworking fluid to separate the emulsion droplets from the metal particles; flowing the contaminated metalworking fluid with the aerated metalworking fluid in a laminar flow to form a combined fluid, wherein the flowing occurs during the formation of the plurality of bubbles and while the emulsion droplets are separated from the metal particles, and wherein the laminar flow lasts for a time sufficient for the plurality of bubbles to attach to the metal particles; releasing the combined fluid into a flotation tank; and removing the metal particles to form a second clean metalworking fluid.
    Type: Grant
    Filed: October 21, 2022
    Date of Patent: September 17, 2024
    Assignee: Quaker Chemical Corporation
    Inventor: John Michael Burke
  • Patent number: 12091633
    Abstract: A process for dry fractionation of a soft palm oil mid fraction (SPMF) into a final hard palm oil mid fraction (fHPMF-A) is disclosed. The process comprises: providing the solf palm oil mid fraction (SPMF), using the soft palm oil mid fraction (SPMF) as an input (IN1) to a first dry fractionation (FDF) to obtain an intermediate olein fraction (SPMF-O) and an intermediate stearin fraction (SPMF-S), using the intermediate olein fraction (SPMF-O) as an input (IN2) to an ultrasound assisted second dry fractionation (SDF) to obtain the final hard palm oil mid fraction (fHPMF-A) and a palm oil olein fraction (POO), wherein the ultrasound assisted second dry fractionation (SPF) comprises subjecting at least a part of the input (IN2) to ultrasonic treatment (US2). Also disclosed is a final hard palm oil mid fraction (fHPMF-A), a second hard palm oil mid fraction (sHPMF-B), a hard palm oil mid fraction mixture, and uses of these.
    Type: Grant
    Filed: August 20, 2019
    Date of Patent: September 17, 2024
    Assignee: AAK AB (PUBL)
    Inventor: Jeppe Lindegaard Hjorth
  • Patent number: 12091634
    Abstract: A wooden wick comprising a strip of wood. Such wick further includes a wood booster member connected to the strip of wood. At least the strip of wood or the booster member comprises a grain, wherein the grain is figured.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: September 17, 2024
    Inventor: Melynda S. Delcotto
  • Patent number: 12091635
    Abstract: Disclosed is a surfactant composition in which at least one of surface tension and interfacial tension is superior, the composition including a fluorinated surfactant and a phospholipid-based surfactant, and optionally further including a sulfosuccinate-based surfactant.
    Type: Grant
    Filed: December 2, 2021
    Date of Patent: September 17, 2024
    Assignee: AK ChemTech CO., LTD.
    Inventors: Hyun Chul Kang, Won Jun Jeong, Bu Hyeon Kim, Hyun Pil Yu, Ki Ho Park, Won Gook Shin, Byung Jo Kim
  • Patent number: 12091636
    Abstract: A composition for dissolving abrasive particles, and a cleaning method using the composition are provided. The composition includes a sulfur-containing organic acid, a fluorine ion-containing compound, and a solvent, and a turbidity change rate (%) measured at 60° C. for 15 minutes may be in a range of ?80 to ?99.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: September 17, 2024
    Assignee: KCTECH CO., LTD.
    Inventors: Kyong Jin Jung, Ga Young Jung, Young Ho Yun, Kun Hee Park, Young Gon Kim, Yong Ho Jeong
  • Patent number: 12091637
    Abstract: The need for a hand-dishwashing composition which is highly effective at emulsifying grease is met by formulating the liquid hand dishwashing cleaning composition to comprise a surfactant system having a combination of alkyl sulphate anionic surfactant and a co-surfactant comprising at least 70% by weight of the co-surfactant of a betaine, in combination with a polypropyleneglycol having a weight average molecular weight from 500 g/mol to 1800 g/mol.
    Type: Grant
    Filed: September 17, 2021
    Date of Patent: September 17, 2024
    Assignee: The Procter & Gamble Company
    Inventor: Pieter Jan Maria Saveyn
  • Patent number: 12091638
    Abstract: A one-piece combination detergent tablet is provided and includes: a detergent composition body A, a color-care and anti-stain composition body B, and an antibacterial and softening composition body C. The detergent composition body A includes: an anionic surfactant A, a non-ionic surfactant A, a polymeric water-soluble film A, an additive A, and water. The color-care and anti-stain composition body B includes: an anionic surfactant B; a non-ionic surfactant B; a polymeric water-soluble film B; an additive B; and water. The antibacterial and softening composition body C includes: a non-ionic surfactant C, a quaternary ammonium cationic surfactant, a polymeric water-soluble film C an additive C, and water. The one-piece combination detergent tablet can be stably stored and has an extended shelf life and a reduced transportation costs.
    Type: Grant
    Filed: January 25, 2024
    Date of Patent: September 17, 2024
    Inventors: Jianfeng Sun, Fenglei Li, Min Sun, Xiangjian Zeng, Na Lan, Yumei Huang
  • Patent number: 12091639
    Abstract: Provided herein are detergent compositions in solid sheet form that include a detergent component and activated charcoal dispersed in the detergent sheet. The activated charcoal is lightweight, porous and has high surface area to weight ratio. The detergent component and activated charcoal work synergistically to enhance cleaning and stain removal efficacy. The detergent compositions may be a laundry detergent sheet or a toilet bowl cleaner sheet.
    Type: Grant
    Filed: January 17, 2024
    Date of Patent: September 17, 2024
    Assignee: Venus Laboratories, Inc.
    Inventors: Jenna L. Arkin, Ryan K. Hood, Johanna Sandoval, Marlene Raigoza, James W. Davis
  • Patent number: 12091640
    Abstract: Provided herein are formulations for liquidless cleansing products having high biobased content. The cleansing formulations may be substantially free of polyvinyl alcohol. The cleansing composition may contain no more than a negligible amount of polyvinyl alcohol. The cleansing composition may contain no detectable amount of polyvinyl alcohol.
    Type: Grant
    Filed: September 11, 2023
    Date of Patent: September 17, 2024
    Assignee: Venus Laboratories, Inc.
    Inventors: Jenna A. Arkin, Ryan K. Hood, Trung T. Phan
  • Patent number: 12091641
    Abstract: The invention is directed to a high flashpoint alcohol based cleaning, sanitizing and disinfecting composition and its method of use on food contact surfaces. More particularly, the present invention relates to a quick drying and ready to use cleaning and sanitizing formula with an isopropyl alcohol level low enough to permit a reduced flammability rating while maintaining microbiological sanitizing and disinfecting properties.
    Type: Grant
    Filed: October 21, 2020
    Date of Patent: September 17, 2024
    Assignee: ECOLAB USA INC.
    Inventors: Robert J. Ryther, Nicole M. Delaney, Jesse D. Hines, Linda E. Grieme
  • Patent number: 12091642
    Abstract: A composition for removing iron deposits, rust, or metallic particles from a surface, the composition including: at least one reducing agent; at least one chelating agent that changes color upon chelation; and at least one solvent.
    Type: Grant
    Filed: December 27, 2023
    Date of Patent: September 17, 2024
    Assignee: Stoner Incorporated
    Inventors: Jared H. Nash, Matthew J. Gilkey, Jonathan E. Crothers, Robert W. Sweger, Harry T. Zechman, III
  • Patent number: 12091643
    Abstract: A process of removing microorganism from an article of clothing is provided in which the process comprises the steps of a) providing an article of clothing in a washing machine; and b) contacting the article of clothing during a wash sub-cycle of the washing machine with a liquid detergent composition comprising a surfactant system and an organic acid, wherein the composition has a neat pH of from 1.5 to 5.0.
    Type: Grant
    Filed: November 8, 2021
    Date of Patent: September 17, 2024
    Assignee: The Procter & Gamble Company
    Inventors: Haiyan Huang, Ryohei Ohtani, Yijia Cao, Yuxiang Liu
  • Patent number: 12091644
    Abstract: A laundry scent additive having polyethylene glycol repeat units and perfume. The laundry scent additive enables consumers to control the amount of scent imparted to their laundry.
    Type: Grant
    Filed: December 13, 2023
    Date of Patent: September 17, 2024
    Assignee: The Procter & Gamble Company
    Inventor: Yousef Georges Aouad
  • Patent number: 12091645
    Abstract: In an embodiment of the present invention, contaminants contained in polycrystalline silicon are removed to obtain highly-pure polycrystalline silicon, with only a small amount of etching. Polycrystalline silicon is washed with use of: a first washing step of bringing fluonitric acid into contact with the polycrystalline silicon; and a second washing step of bringing a non-oxidizing chemical containing hydrofluoric acid into contact with the polycrystalline silicon that has undergone the first washing step.
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: September 17, 2024
    Assignee: TOKUYAMA CORPORATION
    Inventors: Hiroyuki Tasaki, Kazuhiro Kawaguchi
  • Patent number: 12091646
    Abstract: The present disclosure provides methods for treating one or more grains in an ethanol plant or alcohol brewery, methods of drying, cooling, disease control of dried distillers grains with soluble (DDG), barley, or brewer's spent grain (BSG), and a system for treating one or more grains in an ethanol plant or alcohol brewery by these disclosed methods.
    Type: Grant
    Filed: February 17, 2023
    Date of Patent: September 17, 2024
    Assignee: FERMENTATION TECHNOLOGY SERVICES
    Inventor: Steffen Mueller
  • Patent number: 12091647
    Abstract: A moving bed biofilm reactor system for growing microorganisms comprising a reservoir containing a fluid that contains nutrients conducive to growth of microorganisms and a plurality of inert biomass carriers having a surface area configured to support growth of microorganisms is provided. The microorganisms may be used to remove a pollutant from a fluid. Furthermore, the microorganisms may be harvested and used as a foodstuff fertilizer, biofuels, and bioplastics.
    Type: Grant
    Filed: March 8, 2021
    Date of Patent: September 17, 2024
    Assignee: KIMLE AQUACULTURE, LLC
    Inventors: Jackson Kimle, Matthew Ellis
  • Patent number: 12091648
    Abstract: The systems and methods disclosed herein provide for the efficient generation of fine bubbles. In particular, systems and methods for use in bioreactors are disclosed herein providing a superior means to produce useful fermentation products by the biological fermentation of fine bubble waste substrates injected into a liquid broth containing a microorganism culture.
    Type: Grant
    Filed: November 3, 2021
    Date of Patent: September 17, 2024
    Assignee: LanzaTech, Inc.
    Inventors: Rachel Jane Brenc, Robert John Conrado, Joss Anton Coombes, Elham Ebrahimiaqda, Allan Haiming Gao, Brian Nelson Horton, Xueliang Li, Mayur Sathe, Curtis Paul Studebaker
  • Patent number: 12091649
    Abstract: A yeast storage and transfer vessel having semi-permeable materials and a method for transfer of liquid yeast to a fermentor using said vessel and a peristaltic pump. In some embodiments, one or more opening(s) may include a port and valves and/or filters allowing the egress of carbon dioxide and other fermentation gases out of the yeast vessel. The bag storage vessel materials may also include semi-permeable materials. The herein disclosed apparatus and method permit the sterile transfer and mixing of yeast and/or fermentation product into a variety of fermentors, in addition to sterile pumping action in the reverse direction.
    Type: Grant
    Filed: August 20, 2021
    Date of Patent: September 17, 2024
    Assignee: WLDNA, LLC
    Inventor: Chris White
  • Patent number: 12091650
    Abstract: The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems.
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: September 17, 2024
    Assignee: EMULATE, INC.
    Inventors: S. Jordan Kerns, Norman Wen, Carolina Lucchesi, Christopher David Hinojosa, Jacob Fraser, Geraldine Hamilton, Gad Vatine, Samuel Sances, Clive Svendsen, Daniel Levner, Dhruv Sareen
  • Patent number: 12091651
    Abstract: An automated isolation device for isolation of mitochondria includes an incubation station including a holder for a viable mitochondria solution; and a cooling system, controlled by a processor of the device, for cooling the holder. The device includes a processor-controlled transfer system for transferring solution from the holder to a filtration station; and the filtration station, including a series of filters. The device includes a processor-controlled spectrometry station including a spectrometer positioned to illuminate a cuvette fluidically coupled to an output of the filtration station; and a detector coupled to the processor and positioned on a side of the cuvette opposite the spectrometer. The device includes a processor-controlled transfer system for transferring solution from the spectrometry station to a centrifuge. The centrifuge is processor-controlled and configured to centrifuge the filtrate to separate viable mitochondria from a supernatant.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: September 17, 2024
    Assignee: Children's Medical Center Corporation
    Inventors: James D. McCully, Douglas B. Cowan, Pedro J. Del Nido, Thomas Duignan
  • Patent number: 12091652
    Abstract: This disclosure provides, inter alia, an optimized strain of Nitrosomonas eutropha (N. eutropha) designated D23, D23-100, or AOB D23-100. N. eutropha bacteria disclosed in this application have desirable properties, e.g., optimized properties, such as the ability to suppress growth of pathogenic bacteria, and an enhanced ability to produce nitric oxide and nitric oxide precursors. The N. eutropha herein may be used, for instance, to treat diseases associated with low nitrite levels, skin diseases, and diseases caused by pathogenic bacteria.
    Type: Grant
    Filed: November 23, 2020
    Date of Patent: September 17, 2024
    Assignee: AOBIOME LLC
    Inventors: David R. Whitlock, Spiros Jamas, Larry Weiss, Ioannis Gryllos
  • Patent number: 12091653
    Abstract: The present disclosure discloses a novel strain of Glutamicibacter, derived from insects, which efficiently degrades bifenthrin, belonging to the field of microbial strains. The Glutamicibacter CCTCC NO: M20221445 of the present disclosure was isolated from the intestinal tract of bifenthrin-resistant Ectropis grisescens Warren larvae. It exhibits unique genomic characteristics, growth and phenotypic traits, physiological and biochemical characteristics, as well as the ability to utilize and degrade bifenthrin efficiently. Specifically, it can effectively degrade bifenthrin. Based on phenotypic features, physiological and biochemical characteristics, chemical composition, and molecular biology-based polyphasic classification, Glutamicibacter CCTCC NO: M20221445 is identified as a new species. This bacterium possesses the capability to efficiently degrade bifenthrin, laying the foundation for biological control of E. grisescens and offering new microbial resources to address pesticide residue problems.
    Type: Grant
    Filed: December 1, 2023
    Date of Patent: September 17, 2024
    Assignee: ANHUI AGRICULTURAL UNIVERSITY
    Inventors: Yanhua Long, Xiayu Li, Ting Fang, Hao Gui, Meiqi Wang, Haiyue Wang, Yanru Bao, Anqi Shi, Yuhan Pan, Linlin Zhou, Xiaochun Wan, Yunqiu Yang
  • Patent number: 12091654
    Abstract: The device uses pulsed electric fields to prevent the growth of biofilm and the attachment of bacteria to targeted surfaces. The device sets up an electric field around or surrounding the surface itself. These pulsed electric fields disrupt biofilm formation and bacterial attachment to surfaces. The device is meant to prevent the formation of biofilm or attachment of bacteria to a surface as opposed to disinfecting the surface.
    Type: Grant
    Filed: January 20, 2022
    Date of Patent: September 17, 2024
    Inventors: Emily Chen Tang, Bryan Michael Gerber, Chadwick Phillip Pearson, Harsimran Panesar
  • Patent number: 12091655
    Abstract: A method to selectively permeabilize and/or fragmentize cells. A structure comprising a material and particles able to absorb electromagnetic radiation and cells are brought at close distance from each other. Part of the particles embedded in the structure are exposed to the free surface of the structure. The structure and, in particular, the particles in the structure are irradiated with electromagnetic radiation to selectively permeabilize and/or fragmentize the cells. Furthermore, the disclosure relates to a structure for use in a photothermal process to selectively permeabilize and/or fragmentize cells.
    Type: Grant
    Filed: March 22, 2022
    Date of Patent: September 17, 2024
    Assignee: Universiteit Gent
    Inventors: Kevin Braeckmans, Stefaan De Smedt, Félix Sauvage, Aranit Harizaj, Ranhua Xiong
  • Patent number: 12091656
    Abstract: The present invention pertains to a novel method for the generation of highly diverse RNA expressing vectors and vector libraries for use in targeted gene knock out, knock down and genome modification approaches. The invention pertains to a method for generating such higher order libraries without the need of classical cloning technologies. This is particularly useful for libraries based on large vectors wherein a sequence cannot be easily mutated with classical mutagenesis methods. The vectors and libraries generated according to the methods of the invention are in particular for RNA assisted silencing technologies such as RNA interference, and for targeted genome editing using the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system or similar RNA/DNA-encoded gene perturbation systems which use small guide RNAs to target the CRISPR complex to a specific genomic sequence. The invention provides also kits comprising the materials for performing the methods of the invention.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: September 17, 2024
    Assignee: Johann Wolfgang Goethe-Universität Frankfur
    Inventors: Manuel Kaulich, Andreas Ernst, Martin Wegner, Valentina Diehl, Rahel De Bruyn, Svenja Wiechmann
  • Patent number: 12091657
    Abstract: Provided herein are compositions and methods for the incorporation of unnatural nucleotides using mutant polymerases, such as reverse transcriptases. Further provided herein are methods of detection and sequencing of polynucleotide sequences. In some aspects, the compositions and methods are used enhance the efficiency and speed of detecting nucleotide bases. The methods and compositions described herein may further reduce time, cost, or scale of devices for next generation sequencing platforms.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: September 17, 2024
    Assignee: ELEMENT BIOSCIENCES, INC.
    Inventors: Matthew Kellinger, Molly He, Tyler Lopez
  • Patent number: 12091658
    Abstract: Pichia pastoris alcohol dehydrogenase 2 (ADH2) promoter variants include at least one of the specified modifications on wild-type Pichia pastoris ADH2 promoter (SEQ ID NO: 1). The modification includes one of the following mutations: integration of a Cat8 transcription factor binding site (TFBS), particularly integration of SEQ ID NO: 3 or other gene sequences that show at least 80% similarity with this sequence, at any positions within nucleotides a) 647 to 660; b) 739 to 752; c) 1 to 948; and d) mutations specified with SEQ ID NO: 2 within nucleotides 15 to 848 separately and combinations thereof.
    Type: Grant
    Filed: September 23, 2019
    Date of Patent: September 17, 2024
    Assignee: ORTA DOGU TEKNIK UNIVERSITESI
    Inventors: Pinar Calik, Burcu Gunduz Ergun
  • Patent number: 12091659
    Abstract: Aspects of the disclosure relate to barcoded chimeric adeno-associated virus (AAV) capsid libraries, chimeric capsids and related recombinant AAVs (rAAVs) identified using the libraries. Specifically, the chimeric AAV capsid libraries comprise a plurality of nucleic adds encoding AAV capsid proteins, wherein each nucleic acid (i) encodes a unique AAV capsid protein having distinct polypeptide regions of greater than six amino acids in length that are derived from at least two different AAV serotypes, and (ii) comprises a unique barcode sequence. Further disclosed are methods of preparing an AAV library and identifying AAV capsids tropic for a target tissue.
    Type: Grant
    Filed: May 21, 2020
    Date of Patent: September 17, 2024
    Assignee: University of Massachusetts
    Inventors: Miguel Sena Esteves, Sourav Roy Choudhury
  • Patent number: 12091660
    Abstract: Compositions and methods are provided for detection of dynamic loci in a genome, where such loci may comprise structural variations as a result of DNA recombination; DNA duplication, insertions, deletions, transpositions, and epigenetic changes. The methods may utilize microfluidic platforms and functionalized polymer matrices to allow determination of mechanisms of cell-type-specific, programmed genomic heterogeneity. The method and compositions allow determination of mechanisms of cell-type-specific, programmed genomic heterogeneity.
    Type: Grant
    Filed: April 10, 2023
    Date of Patent: September 17, 2024
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Board of Regents, The University of Texas System
    Inventors: Massa Shoura, Andrew Z. Fire, Stephen Levene
  • Patent number: 12091661
    Abstract: The present disclosure relates to methods of treating heat shock factor 1 (HSF1)-related diseases such as cancer and viral diseases, using a therapeutically effective amount of a RNAi agent to HSF.
    Type: Grant
    Filed: April 6, 2022
    Date of Patent: September 17, 2024
    Assignee: Arrowhead Pharmaceuticals, Inc.
    Inventors: Gregory Hinkle, Satyanarayana Kuchimanchi, Stuart Milstein, Markus Warmuth, Wenlai Zhou, Ping Zhu, Tracy S. Zimmermann
  • Patent number: 12091662
    Abstract: Disclosed herein are antisense compounds and methods for decreasing Tau mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Tau-associated diseases, disorders, and conditions.
    Type: Grant
    Filed: January 18, 2023
    Date of Patent: September 17, 2024
    Assignee: Biogen MA Inc.
    Inventors: Holly Kordasiewicz, Eric E. Swayze, Susan M. Freier, Huynh-Hoa Bui
  • Patent number: 12091663
    Abstract: Disclosed herein is a modified ribonucleotide comprising a nucleoside comprising N4-acetylcytidine and/or 5-hydroxymethyluridine, and polyribonucleotides comprising the same. Also provided herein are compositions comprising a polyribonucleotide of the present disclosure and methods of making and using the same.
    Type: Grant
    Filed: August 17, 2023
    Date of Patent: September 17, 2024
    Assignee: Helix Nanotechnologies Inc
    Inventors: Nikhil Dhar, Marianna Keaveney, Kyle Backman, Everett Webster, Nikolai Eroshenko, Justin Quinn
  • Patent number: 12091664
    Abstract: The invention provides methods for treating ischemia (such as ischemia repertusion injury (IRI)) in tissue (such as transplant donor tissue), comprising contacting the tissue during ex vivo perfusion with a therapeutically effective amount of RNAi (such as siRNA) that specifically hinds to at least a portion of a gene (such as p53) that mediates ischemic injury in the tissue. The invention's methods additionally decrease the risk of tissue rejection and/or or induce immunological tolerance to transplanted tissue.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: September 17, 2024
    Assignee: UNIVERSITY OF MASSACHUSETTS
    Inventors: Paulo Martins, Xiaofei E., Timothy Kowalik