Abstract: The present invention describes an orthotic back brace. The device comprises shoulder poster straps that are attached to a first waist belt. The shoulder posture straps tighten around the shoulders of the user when the user leans forward, thereby preventing the form of motion. Instead this system will force the user to bend at the knees keeping proper lifting posture. The device can be utilized to prevent back injuries, to support the back, and promote proper posture, which can cut down on back related injuries in the workplace.

Abstract: An absorbent article can have a topsheet layer, a liquid impermeable layer, and an absorbent core positioned between the topsheet layer and the liquid impermeable layer. The absorbent article can further include an exudate management layer in fluid communication with the topsheet layer. In various embodiments, the exudate management layer can be positioned on a body facing surface of the topsheet layer. In various embodiments, the exudate management layer can be positioned between the topsheet layer and the absorbent core. The exudate management layer has a first component which defines an opening for direct passage of body exudates into the absorbent core. The exudate management layer has a second component which at least partially overlaps the first component of the exudate management layer and further extends in the longitudinal direction of the absorbent article in a direction towards the posterior region of the absorbent article.

Abstract: A medical system includes an ostomy appliance, a monitor, and a docking station. The monitor has a processor for processing data and a memory adapted to store the data. The docking station is provided to charge the monitor and/or transfer data from the monitor.

Abstract: An ostomy appliance that comprises a convex ring insert member. The insert member can have a curved body-side surface, an opposing pouch-side surface defining an internal cavity and an annular curved body portion between an outside flange and an engagement portion encircling a centrally-located input opening. The engagement portion can comprise a plurality of spaced-apart flexible tabs. The internal cavity can be defined by interior surfaces of the flexible tabs and the curved body portion. The flexible tabs can have flexibility to bend toward the internal cavity. A backfill material can be applied into the internal cavity along the interior surfaces of at least some of the flexible tabs. The backfill material can be removable from the ring insert. Upon application of the backfill material, the flexibility of some of the flexible tabs can be reduced to provide a localized rigid support segment along the engagement portion.

Abstract: A heating body, in which a heat-generating composition that generates heat in the presence of air, is accommodated in a bag body formed by heat sealing a one-surface side laminated base material including a first base material and a second base material, and a covering material, at a peripheral edge portion thereof. The first base material has a nonwoven fabric layer and a heat sealable resin layer; and the second base material is a sheet in which an olefin-based nonwoven fabric layer and a resin film are laminated using an olefin-based resin. The first base material and the second base material are capable of forming a space into which a body part can be inserted or held. The heat sealable resin layer and the nonwoven fabric layer are bonded together, and the resin film of the second base material and the covering material are bonded together.

Abstract: A device for delivery of a precise amount of pharmaceutical fluid to the eye is provided. The device includes an ampoule for storing a liquid and an aperture through which the liquid is discharged. The device further includes a vibrating membrane that includes a needle which protrudes from the membrane and extends to the aperture to form a needle valve. The needle valve provides hermetic closure of the aperture to enable preservative-free storage of the pharmaceutical fluid in the device. The system further includes an electromagnetic transducer to shift the membrane back and forth in order to discharge liquid through the nozzle. Finally, the system further includes a vent to permit air to enter the ampoule as fluid is ejected from the ampoule. Preferably this vent includes a filter to prevent ingress of microbes or other contaminants to the ampoule.

Abstract: An eye drop or eye wash dispenser assembly includes a dispenser bottle having a nipple for dispensing eye drops, and a cap removably coupleable to the dispenser bottle over the nipple. An eye cup removably fits over at least a portion of the dispenser bottle and couples to the bottle. The eye cup can be coupled to the dispenser bottle in a stowed position where the eye cup is disposed below the nipple, and can be inverted and coupled to the dispenser bottle in a deployed position where the eye cup is disposed so that it extends distally of and around the nipple. The eye cup in the deployed position can be supported on or rest on the periphery of the eye socket to facilitate delivery of eye drops into a user's eye.

Abstract: The invention presents a universal eyedrop adapter designed for efficient and hygienic eye drop administration. The adapter features a one-way valve at the top to prevent backflow, a reduced internal lumen to minimize drop wastage, and a controlled flow design for precise dispensing. The base incorporates spiral grooves for a secure fit and to prevent outflow. Constructed with an antimicrobial material, the adapter is bug-resistant, ensuring a clean application process. The ergonomic design includes a bent angle and a rounded tip to mitigate the risk of eye injury. The administration process involves attaching the adapter to most eyedrop containers, cleaning it and the receiving periorbital region with a sterile wipe, squeezing to dispense a drop at the rounded tip, and then touching the lateral canthus. The user blinks to utilize surface tension and a lateral-to-medial movement, bringing the drop onto the ocular surface.

Abstract: In an ophthalmic laser procedure, a lenticule is formed in the cornea and extracted from the cornea to accomplish vision correction. The ophthalmic laser system is used to form top and bottom lenticule incisions which intersect each other to form an isolated volume of corneal tissue in between. The volume of tissue includes a lenticular portion having a circular or oval shape and a side tab that protrudes from the peripheral of the lenticular portion. The side tab has a radial dimension between 0.5 and 5 mm and a width between 0.5 and 3 mm in. An entry cut is further formed from the anterior corneal surface to the top or bottom lenticule incisions to provide access to the lenticule. During extraction, the surgeon uses the surgical tool to grab the side tab to extract the lenticule.

Abstract: In certain embodiments, an ophthalmic surgical system for adjusting a dimension of an eye includes a camera and a computer. The camera generates a surgical image of the eye in contact with a patient interface, which distorts the cornea. The surgical image includes the pupil with a real pupil diameter. The computer accesses a diagnostic image of the eye with the cornea having a natural curvature. The natural curvature affects the real pupil diameter to yield a diagnostic pupil diameter of the diagnostic image that is different from the real pupil diameter of the surgical image. The computer adjusts the real pupil diameter of the surgical image using an eye model to yield a refracted pupil diameter that takes into account the curvature of the cornea and uses the refracted pupil diameter to compensate for the difference between the diagnostic and real pupil diameters.

Abstract: Disclosed herein is a system, apparatus and method directed to automated adjustment of a positioning of a drainage bag based on at least an amount of tension within a tubing extending from the drainage bag. The system, apparatus and method pertain to an automated drainage bag actuation system that includes at least a first railing, a control box coupled to the first railing and configured to receive mounting fasteners that couple a drainage bag to the control box, the control box including a tension load cell sensor, a first motor, and circuitry electrically coupled to the first motor and the tension load cell sensor. The circuitry is configured to receive data from the tension load cell sensor indicating an amount of tension in tubing extending from the drainage bag and transmit one or more electrical signals to activate the first motor causing adjustment of a positioning of the drainage bag.

Abstract: A system includes a surgical table, a pad disposed on a table portion of the surgical table, and a leg distraction unit configured for modular attachment to the surgical table, the leg distraction unit configured to apply a distraction force to a leg of the patient while the patient is positioned on the pad and the table portion is tilted so that the patient's head is below the patient's hip, wherein the table portion is capable of tilting to a tilt angle in which the distraction force applied to the leg of the patient is counteracted by a combination of a friction force provided by the pad and a force of gravity from the patient being tilted so that the patient is kept from sliding in a direction of the distraction force.

Abstract: A patient securing overlay is provided that includes a sheet of fabric for supporting a patient's torso on a surgical table. The sheet of fabric has an upper surface configured to face the patient and a lower surface configured to face a surgical table mattress or underbody support. The sheet of fabric includes friction enhancing elements applied to at least a portion of the upper surface thereof. The sheet of fabric can include an extension at a foot end of the sheet of fabric that provides material to be tucked under a foot end of the surgical table mattress or underbody support for securing the foot end of the sheet of fabric to the surgical table mattress or underbody support. The extension can include one or more friction enhancing elements.

Abstract: A patient support apparatus, such as a bed, recliner, cot, stretcher, operating table, or the like, includes battery-powered circuitry whose functions are reduced, but not eliminated, as the battery charge level falls below a threshold. Electrical power may be cut off to one or more components of the battery-powered circuitry while still providing battery-supplied electrical power to the other components of the circuitry. A user interface provides battery status data, including a replacement status of a rechargeable battery, and allows a user to select different formats for displaying battery status data. Such formats include displays of battery charge level information not only in manners specific to the battery, but also in manners relative to the patient support apparatus, such as displays of how many, or how much of, one or more functions the patient support apparatus is able to perform based on the battery's current charge level.

Abstract: A patient support apparatus comprise a first frame, a plurality of load cells positioned on the first frame, a second frame, and a control system. The control system includes a controller, the controller is operable to receive a separate signal from each of the plurality of load cells, process the signals to identify, based on transient changes in the forces measured by each of the plurality of load cells, motion of the patient, classify the motion of the patient, and, based on the classification, update a patient profile in a patient record to reflect the characterization of the patient motion.

Abstract: A mattress including: an elastic body; a sheet that is disposed at least above the elastic body and made of any of a conductive sheet and a conductive fiber; and a measurement unit that is configured to measure a change of capacitance of the sheet observed when the elastic body is deformed.

Abstract: A sheet holding arrangement for holding a sheet when transferring a patient placed on the sheet, comprising at least two knobs and at least two holder elements, where the sheet is held between the knobs and holder elements when connected to each other, where the holder element is provided with an opening adapted to allow insertion of the knob through the opening, where the sheet holding arrangement is connectable to a pulling arrangement, where the sheet holding arrangement comprises a connecting member provided with at least two knobs and where the stem comprises a circumferential groove having a shape that corresponds to a semi-circular end section of the holder element, such that the sheet is held between the groove and the semi-circular end section when the holder element is connected to the knob.

Abstract: A system for loading a patient transport apparatus into a vehicle is described. The system includes a loading and unloading system including a track and a trolley supporting a receiver movable between locked and unlocked configurations. The system also includes a patient transport apparatus for attachment to the loading and unloading system including a base, a litter, and a lift mechanism to facilitate arranging the litter at different heights relative to the base with an actuator movable between fully-retracted and fully-extended configurations, a coupler for engaging the receiver to secure the patient transport apparatus, first and second sensors configured to output a first signal and second signal and a controller to determine a target lift configuration during unloading from the emergency based on first and second values and to drive the actuator to the target lift configuration to limit relative movement between the patient transport apparatus and the trolley.

Abstract: Proposed is a rehabilitation exercise device for upper and lower limbs. The rehabilitation exercise device is characterized by including: a first support supporting a user's hand or foot; a second support supporting a user's forearm or calf; a pair of first hinges rotatably connecting the first support and the second support to each other; a third support supporting a user's upper arm or thigh; a pair of second hinges rotatably connecting the second support and the third support to each other; and a drive module selectively mounted on any one of the pair of first hinges and the pair of second hinges, and configured to pivot the first support or the second support.

Abstract: A textile actuator worn by a user comprises a textile envelope that defines a chamber made fluid-impermeable by a fluid-impermeable bladder contained in the textile envelope and/or a fluid-impermeable structure incorporated into the textile envelope. The textile envelope has a pre-determined geometry that produces an equilibrium state at a non-180-angle displacement and that stops further displacement upon pressurization of the chamber and prevents over-extension the joint. A fluid is delivered into or out of the chamber to displace the textile envelope primarily by transitioning from an uninflated state to the pre-determined geometry due to displacement of the textile envelope rather than via stretching or contraction of the textile envelope. When actuated, the textile actuator (a) displaces a body segment of the user and/or (b) supports and holds the body segment of the user in place.

Abstract: Exemplary aspects of a wearable device are described, including a body, an attachment element, and a plurality of energy generators. The body may include a flexible material layer and be conformable about a head of a user. The body may have a power source. The attachment element may include a band to maintain the body about the head of the user and a skin facing surface of the body against skin of the user. The plurality of energy generators may be independently operable to convert electricity from the power source into a plurality of different energy types transmittable towards the skin of the user. At least one of the plurality of energy generators may be disposed at least partially within the flexible material layer. Related apparatus, methods, and systems are described.

Abstract: Embodiments of the present disclosure are directed to systems, devices, and methods of inducing physical effects in tissue, such as dermis, adipose, musculoskeletal, vascular, hepatic tissue, using unfocused or planar, non-cavitating acoustic shock waves. The physical effects include disruption of fibrous extracellular matrix of the targeted tissues. Embodiments of the present disclosure include applying rapid acoustic pulses (e.g., shock waves) to cause a breakdown in the fibrous extracellular matrix to reduce the appearance of cellulite or scars in a treatment area. Such unfocused or planar, non-cavitating acoustic shock waves may induce a tissue reaction, such as reduction of fibrosis, induction of angiogenesis, or lymphangiogenesis.

Abstract: A device is described for delivering a therapeutic vibration to a body. The device may include at least two motors in a housing with unbalanced masses coupled to their axles, such that vibration of the masses causes the two motors and housing to vibrate at a beat frequency 80. The motors and housing may be coupled to the body via a platform which places the motors and housings at or near a resonant structure in the body, creating a coupled oscillation between the platform and the body. The vibration may be based on the input signal, such that the system applies the vibration based on the input signal to the user, wherein the signal may be an audio or video signal. The system may be configured to measure and manipulate the flow of cerebral spinal fluid.

Abstract: An interface system in an exoskeleton includes a base support, a strap assembly, and posterior strut. The posterior strut has a vertical member defining a lower end connecting to the base support, and an upper end connecting to first and second transverse members extending in opposed directions from the vertical member. The first and second transverse members connect to the strap assembly. The interface system is adapted to receive and support an assistive device adapted to augment a user's performance and mitigate repetitive strain injuries.

Abstract: A foot for a crutch has a ground contact portion with a variable camber. The camber angle changes from at least one of a front edge or rear edge of the variable camber, to a maximum camber. In embodiments, the camber increases from the at least one of the front edge or rear edge to the maximum camber region, and then decreases to the other of the front edge or the rear edge. In embodiments, a foot can have two regions of different cambers laterally disposed from each other such that only one of the two regions contacts the ground during a step at any given time.

Abstract: There is provided an apparatus (12) for use in measuring blood pressure. The apparatus (12) comprises a processor (102) configured to acquire a signal indicative of pressure oscillations detected inside a cuff inflated to pressurize a measurement site of a subject undergoing cardiopulmonary resuscitation. The pressure oscillations detected inside the cuff are indicative of a pulse of the subject. The processor (102) is also configured to trigger a blood pressure measurement for the subject based on the pressure oscillations detected inside the cuff.

Abstract: A system for managing treatment of a person in need of emergency assistance is provided. The system includes at least one camera configured to be mounted to a person in need of medical assistance. The system also includes an image processing device, which can be configured to receive images captured by the at least one camera and to process the images to generate a representation of a rescue scene surrounding the person. The system further includes an analysis device. The analysis device can be configured to determine a characteristic associated with a resuscitation activity based on analysis of the representation of the rescue scene generated by the image processing device. A computer-implemented method for managing treatment of a person in need of emergency assistance is also provided.

Abstract: A package for administration of fluid medicinal or nutritional substances features an outer bag with a sterile or sterilized inner chamber and inside chamber a bottle of medicinal or nutritional substance with a neck, a pierceable cap and a device for the withdrawal and/or reconstitution of the substance, placed below the cap of the bottle. The device comprises a perforation needle axially movable to the bottle and an outflow tube extending out of the bag equipped with an openable closure. The perforation needle is crossed longitudinally by a first channel connecting with the closure set open to the outflow tube, and a second channel with a side opening equipped with a hydrophobic filter configured to allow, after perforation of the cap, only air or other gaseous fluids to flow from inside the bottle into the inner chamber of the bag or vice versa.

Abstract: A packaged, sealed container system for stable storage of a formulation of an oxygen-sensitive pharmaceutical compound, the packaged, sealed container system comprising a primary container including therein a formulation of an oxygen-sensitive pharmaceutical compound, a secondary outer container comprising a first flexible sheet layer, an opposing second flexible sheet layer, and a seal disposed along a common peripheral edge of the first and second flexible sheet layers, such that the primary container is disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. An oxygen scavenger is also disposed between and enclosed by the first and second flexible sheet layers of the secondary outer container. The oxygen scavenger is in fluid communication with the contents of the primary container.

Abstract: Compositions and methods for the treatment of onychomycosis. The compositions include a pharmaceutically effective amount of polyhexamethylene biguanide (PHMB), polyaminopropyl biguanide (PAPB), and/or chlorhexidine (CHG) in a petrolatum carrier.

Abstract: Embodiments herein disclose methods relating to diabetic nephropathy (DN); methods for preventing the onset and also for preventing the progressing of DN, as well as the treatment of DN in diabetic subjects comprising administering reparixin and/or ladarixin which are inhibitors of CXCL8 receptor CXCR1 and CXCR2 activation.

Abstract: The present subject matter includes novel chemical formulations having antimicrobial, antifungal, antiseptic, and related effect in a wide range of applications for treating or preventing infections as well as treating various surfaces that may become tainted with infectants. In some embodiments, the formulation includes isoamyl hexanoates and at least one of propanoic and/or isobutyric acid.

Abstract: Disclosed herein are agents that enhance muscle stem cell engraftment, as well as methods and compositions using the same.

Abstract: Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

Abstract: Modified release formulations of gamma-hydroxybutyrate having improved dissolution and pharmacokinetic properties are provided, and therapeutic uses thereof.

Abstract: A therapeutic method for a cat treats chronic kidney disease to inhibit progression of chronic kidney disease into IRIS stage 4 or kidney death of a cat or improve the overall survival rate or the observed survival rate. The therapeutic method for a cat with chronic kidney disease inhibits progression of chronic kidney disease into IRIS stage 4 or kidney death of a cat by administering a therapeutic agent comprising, as an active ingredient, a compound represented by the formula (I) to a cat with stage 3 or 4 chronic kidney disease defined by the staging system established by the International Renal Interest Society (the IRIS staging) in an amount of 90 to 130 ?g of the compound represented by formula (I) daily: wherein R represents hydrogen or a pharmacologically acceptable cation.

Abstract: The invention described here provides methods of efficiently treating vitamin C deficiency-related diseases and other conditions comprising the administration of pharmaceutical compositions comprising ascorbic acid compound(s), such as sodium ascorbate, and one or more pharmaceutically acceptable excipients (e.g., a carrier and optionally other agents, such as a tonicity agent, a chelator, or both). The methods comprise administration of such compositions in ready-to-use (RTU) form, provided in single unit dose packaging, wherein the compositions are stable when stored at 20° C. to 25° C.±2° C. for at least about 3 months. Compositions provided by the invention comprise an osmolality of between about 270 mOsm/kg to about 340 mOsm/kg and do not require dilution or further manipulation prior to use.

Abstract: The invention provides carbazole derivatives for the treatment of fibrotic diseases (pathological collagen deposition) in tissues and organs, and related symptoms, and conditions thereof.

Abstract: Provided herein are maternal neonatal pheromonal agents capable of reducing aggression and improving feeding behavior in a pig. Compositions comprising the pheromonal agents and methods of using the agents to reduce aggression and improve feeding behavior and weight gain in the pig are also provided.

Abstract: Provided herein are maternal neonatal pheromonal agents capable of reducing aggression and improving feeding behavior in a pig. Compositions comprising the pheromonal agents and methods of using the agents to reduce aggression and improve feeding behavior and weight gain in the pig are also provided.

Abstract: The present invention relates to, inter alia, methods of treatment and combinations of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid (Compound 1) useful for the treatment of extra-intestinal manifestations (EIM) in an individual with inflammatory bowel disease (BBD) and for the treatment of pyoderma gangrenosum (PG). In some embodiments, the methods further comprise administering Compound 1, or a pharmaceutically salt, solvate, or hydrate thereof, in combination with a therapeutically effective amount of a compound selected from the group consisting of: a corticosteroid, a 5-aminosalicylic acid derivative, and a TNF-alpha inhibitor; or a corticosteroid, an immunosuppressant, a biologic, an anti-inflammatory agent, and an antibiotic.

Abstract: The present application relates to a method of treating migraine or cluster headache in a human patient, said method comprising administering subcutaneously composition comprising sumatriptan or its pharmaceutically acceptable salt, in an amount equivalent to 3 mg sumatriptan base.

Abstract: A composition of psilocin that is stable including at least one agent or chemical modification that provides enhanced stability. A method making stable psilocin, by providing a formulation of psilocin including at least one agent or chemical modification that provides enhanced stability. A method of treatment of a disease or condition, by administering a composition of psilocin that is stable to an individual and treating the disease or condition.

Abstract: Embodiments relate to a tablet comprising celecoxib and ciprofloxacin or a pharmaceutically acceptable salt thereof, and low viscosity hydroxypropyl methylcellulose having a viscosity of less than 150 cP, when measured as a 2% solution in water at 20° C.

Abstract: Provided are topical analgesic compositions and methods of preparing topical analgesic compositions comprising a stable nano-encapsulating matrix film. The topical analgesic compositions and methods of preparing topical analgesic compositions may be suited for roll-on applicators. Topical analgesic compositions may include 12 to 16 wt. % menthol; 4 to 8 wt. % camphor; 2 to 15 wt. % film-forming polymer; and 50 to 70 wt. % solvent. To be used in a roll-on applicator, the topical analgesic composition has a viscosity from 800 to 1400 centipoise.

Abstract: Abuse deterrent solid dosage formulations containing 5-({[2-Amino-3-(4-carbamoyl-2,6 -dimethyl-phenyl)-propionyl]-[1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-amino}-methyl)-2-methoxy -benzoic acid, and processes for the preparation and administration of these formulations.

Abstract: The present invention is directed to topical ophthalmic compositions of a lipophilic compound and an oligomeric or polymeric carrier wherein the compositions are useful in the treatment and prevention of macular degeneration. The invention also includes methods of treating macular degeneration by using a topical ophthalmic composition of a lipophilic compound and an oligomeric or polymeric carrier.

Abstract: A pharmaceutical composition for modified release comprising (R)-2-(2-aminothiazol-4-yl)-4?-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetic acid anilide or a pharmaceutically acceptable salt thereof, and a carrier for a sustained release pharmaceutical composition, wherein a maximum blood drug concentration (Cmax) when administered in fasted state is 400 ng/ml or less, is disclosed.

Abstract: A method for increasing the number of CD4+ T-lymphocytes in the serum of a subject in need of such treatment comprising administering to the subject a pharmaceutical composition comprising an amount of an L-isomer of ?-lactam effective to increase the number of CD4+ T-lymphocytes in said patient's serum.

Abstract: Methods and compositions are disclosed for diagnosing a patient suspected of suffering from, and for treating a patient suffering from, a disorder such as hypercortisolemia, metabolic syndrome, pre-diabetes, diabetes, Cushing's syndrome, Cushing's Disease, hyperglycemia secondary to hypercortisolemia, a liver disease, a cardiac disorder, high blood pressure, a blood clotting disorder, a cancer, a psychological disorder, weight gain, a disorder of glucose control, a bone disorder (e.g., osteoporosis), hypogonadism, pseudoacromegaly, pituitary tumors, functional hypercortisolism, ACTH secreting tumors, peripheral neuropathy, dyslipidemia and other disorders. The methods and compositions include administration of a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator (GRM).