Abstract: A method for creating a consolidated compound for delivering an immunomodulatory and imiquimod to a patient, comprising diluting immunomodulator extract to a desired dilution by transferring a desired quantity of the concentrated immunomodulator to an associated sterile container, the associated sterile container having a defined volume of diluted immunomodulator after dilution thereof, providing a viscous encapsulation material, selecting a prescribed amount of concentrated immunomodulator, the prescribed amount defined as that amount of the diluted immunomodulator extract required to provide a number of doses equal to the number of dispensable increments from the container containing the viscous encapsulation material, introducing the selected amount of each of the diluted immunomodulator extract into the viscous encapsulation material, introducing an amount of imiquimod into the viscous encapsulation material, and mixing the introduced amount of each of the diluted immunomodulator extracts and the introduc

Abstract: A packaging system for the storage of an ophthalmic device is disclosed. The packaging system comprises a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising (a) one or more osmoprotectants, (b) one or more poloxamer comfort agents and (c) one or more polyol demulcents, wherein the aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.

Abstract: A disinfection system is disclosed. The disinfection system includes a base, a first arm mechanically coupled to the base at a first joint, a second arm mechanically coupled to the first arm at a second joint, and an emission module mechanically coupled to the second arm at a third joint. The emission module may include a third arm that includes one or more scanners configured to emit electromagnetic energy further configured to disinfect a first surface. The emission module may also include the one or more scanners, focusing lens, a lens frame, and a rotary actuator, wherein the rotary actuator is configured to align one of the one or more scanners with the focusing lens to produce a narrow electromagnetic beam, or position the focusing lens out of alignment with the one of the one or more scanners to produce a broad electromagnetic beam.

Abstract: Antimicrobial system that includes distributed disinfection programming that implements a safe lockout protocol. The safe lockout protocol includes in response to a control station producing an arming initiation signal that is ON based on a first input from an operator, tracking a visual inspection signal produced by an arming switch based on a second input. The safe lockout protocol further includes in response to determining that the tracked visual inspection signal is ON and the control station producing an arming completion signal that is ON based on a third input, receiving a disinfection commencement signal that is ON based on a fourth input from the control station. The safe lockout protocol further includes in response to receiving the disinfection commencement signal that is ON based on the fourth input from the control station, controlling power to a luminaire to emit a disinfection light via a primary relay pack regulator.

Abstract: A currency sterilizing machine includes an internal sorting, counting, and stacking mechanism of the type found in conventional currency-counting devices. Within the housing interior is a sterilizing device for disinfecting currency as it passes through the machine. The sterilizing device is either a spray nozzle for dispensing a disinfectant or a plurality of UVC radiators for destroying microorganisms.

Abstract: A hand sanitization system, a sanitization machine, and hand coverings containing markings for use with the sanitization machine are disclosed. The hand sanitization machine is capable of sanitizing hand coverings that were traditionally disposed of after one use. The hand coverings may contain indicators that signal when they have been sterilized.

Abstract: Disclosed herein is a hydrogel that eradicates biofilm bacteria from wounds and accelerates diabetic wound healing. Also disclosed herein are methods of manufacture and use of said hydrogel.

Abstract: The present invention relates to a scaffold for the treatment of stress urinary incontinence, wherein the scaffold comprises three layers of polyurethane: a first layer and a third layer in which the polyurethane fibres are randomly orientated and a second layer between said first and third layers in which the fibres are aligned longitudinally; methods of making such scaffolds and uses thereof.

Abstract: Provided is a cell sheet suitable for cartilage repair. The present invention provides a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the cell sheet is negative for immunostaining using an antibody against type II collagen. The present invention also provides a method for producing a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the method includes culturing cells derived from a cartilage tissue on a surface of a membrane, where a temperature-responsive polymer is immobilized on the surface, to give the cell sheet. The culturing is stopped before the cell sheet becomes positive for immunostaining using an antibody against type II collagen.

Abstract: The present disclosure provides a decellularized extracellular matrix, the preparation process and uses thereof. The decellularized extracellular matrix of the present disclosure is derived from a three-dimensional cell spheroid, and the decellularized extracellular matrix has a three-dimensional spherical structure. The decellularized extracellular matrix of the present disclosure can be used to prepare a biomedical material scaffold for promoting tissue regeneration and repair.

Abstract: A method for forming a biocompatible structure includes the steps of forming a layered structure having alternatively disposed first layers and second layers, where the first layers includes at least one polymer and first particles, and the second layers includes second particles; and treating the layered structure with a washing solvent to form the biocompatible structure, where the first particles are solvable in the washing solvent.

Abstract: The invention relates to crosslinked soft tissue grafts and methods of use thereof. The invention also relates to methods of preparing the same.

Abstract: The invention provides, inter alia, ultra-thin conformal coated biological surfaces, such as living cells, cell clusters, tissues, organs, and hybrid synthetic organs, and methods of making the same, e.g., using click reactive water soluble polymers, under conditions that do not damage or significantly modify the biological surfaces. In some embodiments, the coated biological surfaces are suitable for delivery to a subject in need thereof.

Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.

Abstract: The present invention relates to a bio-electrode having improved conductivity, flexibility and bio-compatibility, and a method of manufacturing the same. Specifically, the present invention relates to a conductive polymer bio-electrode including nano-porous permeable membrane, based on a bio-compatible polymer material having a plurality of pores and an improved surface area based on a PDMS device having a low mechanical strength and an excellent bio-compatibility, bio-signal transmission patterning, and a gold coating layer and has an excellent bio-compatibility and low rejection response while having a conductivity similar to that of a bio-electrode configured with a metal material of the related art. Therefore, the conductive polymer bio-electrode of the present invention is expected to be able to replace a bio-electrode configured with a metal material by which the bio-signal transmission efficiency is degraded due to a high bio-incompatibility.

Abstract: An aerosol generator includes a composite conduit to transport multiple liquids to a heating element at flow rates such that the liquids arrive at the heating element in desirable concentrations. The heating element volatilizes the liquids to form volatilized fluid, which mixes with ambient air to form an aerosol with desirable concentrations of the multiple liquids.

Abstract: An apparatus for irradiating air flow in a vehicle includes a filter unit configured to couple to a recirculating-air conduit connected to a manifold of an air circulation system, the filter unit having an inlet end, and a filter disposed in the inlet end of the filter unit, including an outer High Efficiency Particulate Air (HEPA) media. The apparatus further includes a plurality of ultraviolet light transmissive strands that each have distal ends disposed in a spaced apart manner in an interface region between the outer HEPA media filter and an inner activated carbon filter or HEPA filter, and proximal ends connectable to an ultraviolet light emitting source such that ultraviolet light is transmitted by the transmissive strands into the interface region. The transmissive strands are configured to receive emitted ultraviolet light that is substantially between 222 nm and 265 nm for irradiating air passing through the filter.

Abstract: Apparatus and methods for concentrating platelet-rich plasma is described herein. One variation may generally comprise a tube having a length and defining a channel within and one or more ports located at a proximal end of the tube and in fluid communication with the channel. A plunger may slidably translatable within the channel while forming a seal against an inner surface of the channel and a float may have a pre-selected density and defining a concave interface surface, wherein the float is slidably contained within the channel such that the concave interface surface is in apposition to the one or more ports.

Abstract: The systems, methods, and devices can efficiently express breast milk while being visually and audibly discreet, and portable. The breastmilk expression system for extracting milk from a breast of a female may include an interface configured to deliver suction to a nipple of the breast. The system may include a breastmilk storage container configured to store breastmilk. The system may include a control device operatively coupled to the breastmilk storage container and the interface. The control device may include one or more pressure reservoirs configured to store negative pressure. The control device may be configured to cause passive suction at the interface to cause extraction of the breast milk by controlling delivery of the negative pressure stored in the one or more pressure reservoirs to the interface.

Abstract: A peritoneal dialysis (“PD”) system includes a cycler including an actuation surface having a peristaltic pump actuator; at least one pair of capacitive sensing plates; a manifold assembly including a rigid manifold having at least one chamber, the rigid manifold configured and arranged to be abutted against the actuation surface for operation, wherein the at least one pair of capacitive sensing plates is positioned to be operable with the at least one chamber; a peristaltic pump tube; and a control unit configured to actuate the peristaltic pump actuator to pump dialysis fluid to the at least one chamber, receive a signal from the at least one pair of capacitive sensing plates, count a number of revolutions of the peristaltic pump actuator, determine a current volume per revolution for the peristaltic pump actuator, and use the current volume per revolution for a subsequent operation of the peristaltic pump actuator.

Abstract: An external protective interface is provided for intravenous infusion lines, drive lines, vacuum lines, and monitoring lines for percutaneous access. The interface acts as an airtight seal in concert with a vacuum line to promote accelerated tissue healing to reduce and prevent infection at insertion sites for infusion lines, drive lines, and medical devices. The interface provides additional mechanical stability to an implanted tube or PAD or so as to speed healing around a semi-permanent implanted tube or PAD, as well as connection points for vacuum lines and at least one drive line for the insertion of medical devices. The dense fibroblast ingrowth encouraged by the interface acts to strengthen barriers to infection at the insertion site.

Abstract: The disclosure provides a method of placing a cardiac drainage cannula into a patient's heart. In some embodiments, the method comprises the steps of (a) inserting the cannula percutaneously into an internal jugular vein, (b) advancing the cannula through the internal jugular vein and into the right atrium of the heart, and (c) advancing the cannula through the atrial septum into the left atrium of the heart. Further aspects of the disclosure provide a method of draining blood from the left atrium or left ventricle of a patient's heart using a cardiac drainage cannula. The disclosure also provides a cardiac drainage cannula and a mechanical circulatory support system.

Abstract: Provided is a container for connection to a device for suctioning bodily fluids and for supplying a fluid substance to a human or animal body, said container comprising an interior which is divided into a first region for collecting the suctioned bodily fluids and into a second region for providing the fluid substance, The first region of the interior is separated from the second region by means of a flexibly realized partition wall.

Abstract: A wearable garment for recovery of a wearer after the wearer has undergone a surgical procedure, the wearable garment having an outer shell including at least a back panel and two front panels that, when the wearable garment is worn about a wearer, have outer edges that are adjacent to each other, a fastening system for securing the outer edges of the front panels together, thereby securing the wearable garment about the wearer, a compression region that provides a compressive force about the wearer; straps that hold the wearable garment about the wearer, and a tubing pocket attached to an inner surface of a respective one of the front panels for holding a drain tube in a coiled configuration against the wearer.

Abstract: A heating assembly for a vapour generating device includes a heating device arranged to heat, in use, a body, the body including a vaporisable substance located in use in a heating compartment of the heating assembly, the heating assembly being arranged to supply, in use, power to the heating device to heat the body; a temperature sensor arranged to monitor, in use, a temperature related to heat generated from the body, temperature information related to heat generated from the body being determinable from the monitored temperature; and a memory accessor arranged to access, in use, a memory that holds a relationship between the temperature information, the amount of power supplied to the heating device or the profile of power supplied to the heating device, and at least one condition including an age of the body, or a type of the body, or the presence of the body.

Abstract: An apparatus and method for providing a nebula or aerosol to a patient is described. In one aspect, the nebulizer is composed of a minimum number of parts to reduce complexity for automated or human assembly. The nebulizer may include an inhalation valve, exhalation valve and biasing member integrated into a single diaphragm structure that may be connected with an actuator and inserted into a housing for controlling nebulization of a medicine to a patient in response to the patient's breathing or in a continuous nebulization mode.

Abstract: A respiratory apparatus includes components to protect operations of the apparatus. For example, in some versions, the apparatus may include a power supply, a motor powered by the power supply, and a transient absorption diode circuit between the motor and the power supply. The transient absorption diode circuit may be configured to absorb energy generated by the motor from rotational kinetic energy. Such absorption may serve to protect the components of the apparatus. In some examples, the apparatus may include a fault mitigation integrated circuit (IC). The IC circuit may be included in the respiratory apparatus to detect one or more faults based on physical and system parameters of the apparatus. The fault mitigation integrated circuit may generate a signal to stop the motor based on the detected fault, and may digitally communicate with a processor information about the detected fault.

Abstract: A respiratory ventilation apparatus configured to deliver a respiratory gas to a patient interface is provided. The apparatus may include a gas pressurization unit configured to generate a pressurized respiratory gas, a gas inlet port configured to introduce the respiratory gas into the respiratory ventilation apparatus, a gas outlet port configured to discharge the pressurized respiratory gas to a respiration tube, a detection module configured to detect the pressure of the pressurized respiratory gas, at least one non-volatile memory configured to store a plurality of parameters and a plurality of programs, and one or more controllers. The one or more controllers may be configured to initiate the respiratory ventilation apparatus upon a boot operation, and/or initiate a program that constantly reads information from the detection module, and controls the pressure of the pressurized respiratory gas using the information read from the detection module and at least one parameter.

Abstract: Systems and methods for a manually operable volume-adjustable ventilation device. In some embodiments, the device includes a reservoir with an inlet mechanism, an outlet mechanism, and a volume adjuster configured to move a volume adjustment limit of the reservoir and change an expressed maximum volume of the reservoir. The reservoir may have a body comprising a plurality of movable walls defining an enclosed volume. The walls of the reservoir may be movable such that movement expresses the volume adjustment limit of the reservoir. In addition, the walls may be operably connected by movable structures such that two adjacent walls are be configured to rotate around substantially orthogonal axes with respect to each other when the reservoir moves from an uncompressed to a compressed state. Methods of ventilating a patient that involve the manually operable volume-adjustable ventilation device are also disclosed.

Abstract: This invention relates to, among other embodiments, methods and apparatus/systems for controlling gases delivery to a patient, such as via a patient interface. Such methods comprising receiving an input relating to either a patient's breathing phase and/or another patient parameter, controlling a flow of gases to be delivered to the patient and the inclusion in said flow of gases of a supplementary gas, wherein the amount of supplementary gas provided to the patient is substantially synchronized with respect to the patient's breathing phase and/or another patient parameter.

Abstract: Tube systems may include a tube with an inflatable balloon that is affixed to, and circumferentially surrounding an exterior portion of the tube. The inflatable balloon may be positioned between the first open end and the second open end of the tube. The tube may be flexible and hollow and may have a first open end and a second open end. The tube may include a suction line, a suction line port, and a spacer that extends from an exterior surface of the tube and is positioned proximate to the suction line port. The spacer may be configured to prevent occlusion of the suction line port.

Abstract: A patient interface for use in delivering a flow of a breathing gas to an airway of a patient includes a body that defines a cavity therein that is structured to receive the flow of breathing gas. A first aperture defined in the body is positioned and structured to communicate the flow of breathing gas from the cavity to an airway of the patient. A second aperture defined in the body is sized and configured to provide a pathway between the cavity and an ambient environment in which the body is disposed. The patient interface further includes a restrictor element that is selectively coupled to the body. The restrictor element includes a blocking portion that obstructs at least a portion of the second aperture.

Abstract: Devices, systems, and/or methods for immobilizing a patient's head and simultaneously providing emergency respiration for the patient includes, in some embodiments, a head immobilizer, a bag valve mask (BVM), an endotracheal tube (ET) bracket, and/or an oxygen face mask. In some embodiments where head immobilization is not needed, a cardiopulmonary resuscitation (CPR) board may be used in lieu of the head immobilizer. Each such embodiment is configured to require reduced manual intervention by a caregiver without reducing the effectiveness of each medical device and/or system. An adjustable BVM holder integrated into the head immobilizer secures the BVM on the patient. In embodiments with a BVM, only a single hand is necessary to provide emergency respiration, freeing the caregiver's other hand for other caregiving tasks. Such a head immobilizer may secure an ET bracket and/or face mask to a patient, allowing for hands-free operation during patient treatment, movement, and transportation.

Abstract: A method, system and apparatus for assessing the coupling between lung perfusion and ventilation in a patient who is mechanically ventilated or who is breathing spontaneously through a conventional artificial airway is provided. Embodiments of the apparatus comprise an adaptor configured to fit between the artificial airway and mechanical ventilator, a measuring chamber in constant fluid communication with the adaptor via one or more measuring chamber sampling ports, and a monitoring unit where data obtained from temperature and relative humidity sensors located in the measuring is calibrated, sampled, logged and analyzed together with anthropometric patient data to display a coupling index Qi and to enable ongoing diagnostic cardio-pulmonary monitoring of a patient by comparing changes in the patient's index during a monitoring interval.

Abstract: An apparatus to administer drugs to mechanically ventilated patients includes a mechanical ventilator, an artificial airway to be associated to a patient and a ventilation circuit connecting the mechanical ventilator to the artificial airway. The ventilation circuit includes: an inspiratory line, a dry powder inhaler disposed in line on the inspiratory line and a connector operatively connected to the dry powder inhaler and to the inspiratory line. The connector includes: a first duct facing an outlet port of the dry powder inhaler and connected or configured to be connected to a tube section of the inspiratory line placed downstream the dry powder inhaler; a second duct facing an air inlet port of the dry powder inhaler and connected or configured to be connected to a tube section of the inspiratory line placed upstream the dry powder inhaler.

Abstract: Disclosed is a massage apparatus including a processor configurable to receive a first dataset associated with a physiological parameter of an individual to derive a first emotional indication of the individual; wherein the first emotional indication and the first dataset are configured as inputs to derive a second emotional indication of the individual.

Abstract: A method includes initiating an accelerated daily light and darkness cycle experience at a first color palette position within the accelerated daily light and darkness cycle that corresponds to a current time at a destination geographic location that a user will travel to. The accelerated daily light and darkness cycle experience is executed at a second color palette position within the accelerated daily light and darkness cycle that corresponds to the current time at the destination geographic location of the user. The accelerated daily light and darkness cycle is less than six minutes and includes projecting a dark virtual sky in a digital space, transitioning the dark virtual sky to a dawn virtual sky in the digital space, altering the dawn virtual sky to introduce a daytime virtual sky in the digital space and modifying the daytime virtual sky to produce a dusk virtual sky in the digital space.

Abstract: Systems, devices, and methods described herein relate to multi-sensory presentation devices, including virtual reality (VR) devices, visual display devices, sound devices, haptic devices, and other forms of presentation devices, that are configured to present sensory elements, including visual and/or audio scenes, to a user. In some embodiments, one or more sensors including electroencephalography (EEG) sensors and a photoplethysmography (PPG) sensors, e.g., included in a brain-computer interface, can measure physiological data of a user to monitor a state of the user during the presentation of the visual and/or audio scenes. Such systems, devices, and methods can adapt one or more visual and/or audio scenes based on user physiological data, e.g., to control or manage the state of the user.

Abstract: A catheter pump includes a cannula and an impeller system. The cannula has an inlet zone with a first maximum outer diameter, an outlet zone with a second maximum outer diameter and a blood flow channel extending between the inlet zone and the outlet zone. The first maximum outer diameter is greater than the second maximum outer diameter, and the impeller system has a rotatable impeller body operable to convey blood from the inlet zone to the outlet zone. The impeller body may be axially spaced from the cannula in a separated position.

Abstract: A kit including a sheath having a tubular body with proximal and distal ends, an axis extending between the ends and a wall defining a bore extending along the axis to the distal end of the body. A delivery tube having proximal and distal ends and a lumen is adapted for disposition within the bore of the sheath in sealing engagement with the sheath, the delivery tube being slideable distally relative to the sheath. An elongated cannula having proximal and distal ends and a lumen is adapted for disposition inside the lumen of the delivery tube and an elongated dilator is adapted to fit within the lumen of the cannula with a proximal portion of the dilator extending proximally beyond the proximal ends of the cannula and delivery tube and in sealing engagement with the delivery tube proximal to the cannula.

Abstract: A custom length stylet assembly for meeting medical device length tolerances. The custom length stylet assembly including a stylet wire having a length extending between a distal end and a proximal end, stylet handle defining a longitudinally oriented throughbore sized to retain a proximal portion of the stylet wire, the stylet handle further defining a proximately positioned track and tab, the track configured to retain a bent proximal end portion of the stylet wire, the length of the stylet wire selected during assembly of the stylet assembly to conform to the corresponding length of a body implantable lead within a predefined tolerance, the tab of the stylet handle melted into the track, thereby securely fastening stylet wire to the stylet handle to inhibit rotation or dislodgement.

Abstract: Systems, methods and devices are described including a medical device subassembly including a magnetic feature. Systems include such a catheter adapter subassembly or needle subassembly or guidewire introducer subassembly and a wire including a magnetic feature, and relative movement of the catheter adapter subassembly or needle subassembly or guidewire introducer subassembly and the wire can be determined using a magnetometer.

Abstract: Disclosed herein are steerable catheter assemblies that utilize various mechanisms to accomplish independent control of catheter flex magnitude and catheter flex direction to provide improved steerability of an attached catheter. Some embodiments include a catheter with two or more pull wires that flex the catheter and a control handle coupled to the catheter. The control handle can include a direction control coupled to the two or more pull wires such that adjustment of the direction control adjusts a direction of catheter flex by the two or more pull wires, and the control handle can include a magnitude control coupled to the two or more pull wires such that adjustment of the magnitude control adjusts the magnitude of catheter flex.

Abstract: A deflectable catheter including an outer member having a proximal portion and a distal portion, an elongated column member extending distally from the outer member and an inner member positioned coaxial with the outer member and attached to the column member. The inner member extends distally of the outer member and has a distal tip portion. A reinforcement member is positioned over the column member to restrict axial movement of the column member such that when one of the inner member or outer member is moved with respect to the other, axial compression of the column member is restricted by the reinforcement member causing the distal tip portion of the inner member to deflect laterally.

Abstract: A catheter includes a catheter body and a distal tip section that includes an elongated member that extends along a longitudinal axis. An anchor mechanism can be disposed along an outer surface of the elongated member and/or within the elongated member in a first configuration. In a second configuration, the anchor mechanism can be configured to extend radially outward with respect to the longitudinal axis to surround at least a portion of the distal tip section.

Abstract: A steerable medical apparatus includes a shaft, a steering mechanism, and an actuation mechanism. The shaft has a proximal portion, a distal portion, a first pull wire, and a second pull wire. The distal ends of the first and second pull wires are coupled to the distal portion of the shaft. The steering mechanism has a first wheel and a second wheel coupled by a differential mechanism. The proximal ends of the first and second pull wires are respectively coupled to the first and second wheels. The actuation mechanism is coupled to the steering mechanism. Actuating the actuation mechanism in a first operational mode causes the distal portion of the shaft to curve in a first plane. Actuating the actuation mechanism in a second operational mode causes the distal portion of the shaft to curve away from the first plane.

Abstract: A catheter includes a handle and an elongate member extending from the handle. The catheter may also include steering system coupled to the handle. The steering system may be configured to deflect at least a portion of the elongate member in at least one direction. The catheter may also include a locking mechanism configured to lock the portion of the elongate member in a deflected configuration, and a lever coupled to the handle. The lever may be configured to move from a first position to a second position to engage the locking mechanism. The lever may also be configured to be separably retained at least at one of the first position or the second position to prevent movement therebetween.

Abstract: An integrated catheter assembly for rapid vascular insertion including a catheter configured for receipt of a needle and a guidewire; a catheter assembly comprising an integrated assembly comprising a catheter, needle, and guidewire; and a method of rapidly inserting a catheter to obtain vascular access. The catheter includes a central lumen for receiving the needle and guidewire. The lumen includes a distal port and a transverse side port adjacent an intermediate portion thereof which provide open vascular communication from two ports between the central lumen and the vasculature. The needle and guidewire, when integrated with the catheter, extend through the transverse side port wherein a proximal end of the needle extends contiguous to and exterior of a proximal portion of the catheter.

Abstract: A system for facilitating instrument delivery through a peripheral intravenous catheter (“PIVC”) may include a catheter assembly having a catheter adapter, an extension tube extending from a side port of the catheter adapter, a septum disposed in a lumen of the catheter adapter, and a PIVC extending distally from the catheter adapter. The septum may include a first piece and a second piece and may be least partially disposed within a canister. The system may include an extension set, which may include a distal end and a proximal end. The distal end may include a distal connector and a rigid tube. The proximal end may include a proximal connector. The distal connector may be coupled to the proximal end of the catheter adapter. The rigid tube may penetrate the septum in response to the distal connector being coupled to the proximal end of the catheter adapter.

Abstract: A catheter system may include a catheter adapter, which may include a distal end, a proximal end, and a lumen extending through the distal end of the catheter adapter and the proximal end of the catheter adapter. The catheter system may include a septum assembly disposed within the lumen of the catheter adapter. The catheter system may include a catheter extending from the distal end of the catheter adapter. The catheter system may include an introducer needle, which may include a proximal end, a sharp distal tip, and a bump disposed between the proximal end and the sharp distal tip. The proximal end of the introducer needle may be secured within a needle hub of the catheter system. In response to the bump contacting the septum assembly, the sharp distal tip of the introducer needle is disposed distal to a distal end of the catheter.