Abstract: From gene expression analysis with a long-term recurrence-free group and a recurrence metastasis group of stomach cancer, CHRNB2 and NPTXR were identified as drug discovery targets. Tumor growth was successfully inhibited by an antibody medicine or a nucleic acid medicine targeting CHRNB2 or NPTXR. Furthermore, a polyclonal antibody and a monoclonal antibody linking to CHRNB2 or NPTXR are provided. Since these receptor molecules are novel molecular targets, treatment of cases which the existing therapeutic drugs have no effect on is made possible.

Abstract: The present invention relates to an antibody against a PDGF receptor, an antibody-drug conjugate in which a chemotherapeutic agent is conjugated to the antibody against PDGF receptor, and a use of prevention or treatment of ocular neovascular diseases.

Abstract: The present invention provides methods for treating, preventing or ameliorating a neutrophilic dermatosis. The methods of the present invention include administering to a patient suffering from a neutrophilic dermatosis a pharmaceutical composition including an anti-interleukin-36 receptor (anti-IL-36R) antibody.

Abstract: Provided are methods for preventing or ameliorating toxicity caused by or due to a therapy, such as an immunotherapy or a cell therapy, by pre-emptive or early administration toxicity-targeting agent(s). In some embodiments, the therapy is a cell therapy in which the cells generally express recombinant receptors such as chimeric receptors, e.g., chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the methods, including the timing of the administration of the agents or treatments for toxicity, provide various advantages, such as lower toxicity while maintaining persistence and efficacy of the administered cells.

Abstract: An asymmetric fusion protein in which a fragment of an antibody binding to an insulin receptor, an iduronate-2-sulfatase (IDS) enzyme, and an Fc region are fused, and a use thereof are disclosed. The fusion protein can cross the blood-brain barrier (BBB) to deliver the IDS enzyme to the brain. Therefore, a pharmaceutical composition containing the fusion protein as an active ingredient can be used as a therapeutic agent for a central nervous system disease and particularly, is expected to prevent and treat various diseases caused by ribosome accumulation.

Abstract: Disclosed are methods of treating cancers and enhancing efficacy of BCMAxCD3 bispecific antibodies. In particular, methods are disclosed of using a BCMAxCD3 bispecific antibody, an anti-CD38 antibody and/or pomalidomide to treat cancers, particularly relapsed or refractory multiple myeloma.

Abstract: The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.

Abstract: In combination with conventional therapies (e.g. targeted therapy, chemotherapy, and angiogenesis inhibitors, etc.), immunotherapies targeting checkpoint molecules have shown promise in the treatment of solid or liquid tumors. However, the role of non-tumor cells in the intratumoral microenvironment has indicated that ablation of these cells may be a key to mounting an effective immune response against the tumor which includes tumor infiltration of cytotoxic T-cells and other anti-tumor cells of the immune system. Rather than focusing on trying to inhibit the ectonucleotidase activity of CD39 as an enzyme that generates adenosine, the present invention instead utilizes CD39 expression to bring about intratumoral cell ablation by CD39-depedent ADCC.

Abstract: The present invention generally relates to antibodies that bind to HLA-A2/WT1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.

Abstract: Provided are methods of treating cancer that comprise administering a polypeptide (e.g. a fusion polypeptide) that comprises a SIRP? D1 domain variant and an Fc domain variant in combination with at least one chemotherapy agent and/or at least one therapeutic antibody. Also provided are related kits.

Abstract: The disclosure provides constructs comprising a first fusion protein, a second fusion protein, and a linker, wherein the first fusion protein and the second fusion protein each include an affinity reagent and a reactive enzyme, and the linker includes a first and second functional groups specific for irreversibly inhibiting the first and second fusion protein reactive enzymes. The disclosure further provides a method including (a) contacting a first fusion protein including an affinity reagent and a reactive enzyme with a linker including a functional group specific for irreversibly inhibiting the first fusion protein reactive enzyme thereby coupling the first fusion protein and the linker, and (b) contacting a second fusion protein including an affinity reagent and a reactive enzyme with the linker, the linker including a functional group specific for irreversibly inhibiting the second fusion protein reactive enzyme thereby coupling the second fusion protein and the linker.

Abstract: The present disclosure is concerned with dipeptide compounds for the treatment of various cancers such as, for example, sarcomas, carcinomas, hematological cancers, solid tumors, breast cancer, cervical cancer, gastrointestinal cancer, colorectal cancer, brain cancer, skin cancer, prostate cancer, ovarian cancer, bladder cancer, thyroid cancer, testicular cancer, pancreatic cancer, endometrial cancer, melanomas, gliomas, leukemias, lymphomas, chronic myeloproliferative disorders, myelodysplastic syndromes, myeloproliferative neoplasms, and plasma cell neoplasms (myelomas). This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention relates to a fusion peptide having one of the following formulae: P1-L-P2 (I) or P2-L-P1 (II) wherein P1 is chosen from the proline-rich antimicrobial peptides; Lisa peptide linker; and P2 has the following formula (III): wherein m is 0 or 1; n is an integer comprised between 0 and 9; p is an integer comprised between 0 and 10; r is 0, 1 or 2; s is 0 or 1; Gln is glutamine; R1 is the side chain of arginine or lysine; R2 is for example a —(CH2)—C3-6-cycloalkyl group optionally substituted; R3 is for example a C1-8-alkyl group; R4 is in particular a C1-8-alkyl group optionally substituted by a C3-6-cycloalkyl group; R5 is for example a —(CH2)—C3-6-cycloalkyl group; R6 is in particular —COOH, wherein, when the fusion peptide has the formula (II), its C-terminus contains a —CO— group engaged in a peptide bond with said linker.

Abstract: The present invention provides a manufacturing process for preparing a peptide, preferably a decapeptide, such as degarelix, by incorporating p-nitro-phenylalanin in the amino acid sequence preferably during stepwise solid phase synthesis, and converting these into the required amino acids Aph(Hor) and/or D-Aph(Cbm), preferably while attached to a solid phase. The invention further provides intermediates useful in the manufacturing process.

Abstract: A method for drying polyolefin-containing particles includes a drying step of supplying polyolefin-containing particles to a drying container and drying the polyolefin-containing particles in the drying container. In the drying step, a value determined by the following formula (a) is ?0.20 or more and 1.05 or less. 0.00304×apparatus diameter [m]+0.00261×bed height [m]+0.0179×residence time [hr]+0.00213×particle temperature in drying container [K]?0.0109×inclination angle [degree]+0.

Abstract: A liquid composition comprising a polymer having pendant groups of the formula I: (I) Wherein X is either a bond or is a linking group having 1 to 8 carbons and optionally 1 to 4 heteroatoms selected from O, N and S; and n is 1 to 4.

Abstract: A purge system for a polymerization system may include a purge column including a stripping zone and a stripping fluid distributor below the stripping zone for injecting a stripping fluid including one or more light olefins. A first displacement zone is below the distributor. A second displacement zone is below the first displacement zone. A nitrogen distributor introduces nitrogen in the second displacement zone. Another purge system for a polymerization system may include a fluidized bed separator and a purge column. The fluidized bed separator includes a separator inlet, a stripping fluid inlet, a first stripped fluid outlet, and a separator outlet. The purge column includes a flake inlet, a stripping zone, a stripping fluid distributor below the stripping zone, a stripped flake outlet, and a second stripped fluid outlet for a second stripped fluid from the purge column.

Abstract: The present invention relates to a process for producing an aqueous polymer dispersion by free-radically initiated aqueous emulsion polymerization, by polymerizing, in an aqueous medium, (a) 40 to 75 parts by weight of at least one vinylaromatic compound and (b) 24.9 to 59.9 parts by weight of at least one conjugated aliphatic diene (c) 0.

Abstract: The invention provides a living radical polymerization method using a zinc phthalocyanine dye as a near-infrared photocatalyst, including subjecting a free radical polymerizable monomer to a near-infrared light-controlled polymerization reaction, in the presence of a chain transfer agent, a cocatalyst and a zinc phthalocyanine dye containing a carbon-carbon double bond, in a solvent at 0-30° C. under the air atmosphere, to obtain a living radical polymerization product. The free radical polymerizable monomer is an acrylate monomer, a methacrylate monomer, an acrylamide monomer or a methacrylamide monomer; the chain transfer agent includes a thiocarbonate; and the cocatalyst includes an organic amine with or without a carbon-carbon double bond.

Abstract: In the present disclosure, there are provided a polyethylene having improved low-temperature sealing properties with an increase in the content and molecular weight of a low crystalline polymer, and a method for preparing the same.

Abstract: The present invention discloses a preparation method for an amphiphilic nanosheet. The preparation method comprises the following steps: mixing choline chloride and urea, and heating to prepare a choline chloride-urea based deep eutectic solvent; adding styrene, divinylbenzene and azobisisobutyronitrile into a higher alkane solvent, stirring and dissolving to obtain an oil phase solvent, wherein an addition amount of the divinylbenzene is greater than 5% by mass of a styrene monomer; and adding a hydrophilic monomer, cetyltrimethylammonium chloride and the oil phase solvent into the deep eutectic solvent, stirring and mixing, ventilating and deoxidizing, then heating to 70° C., reacting for at least 6 h, and then crushing and centrifuging to obtain the amphiphilic nanosheet.

Abstract: To provide a polymer wherein a linking group that connects the main chain of the polymer and a cyclic perfluoroaliphatic disulfonimide skeleton, is a fluoroalkylene group which may have an ether oxygen atom. A polymer which has either one or both of units represented by formula u1-1 and units represented by formula u1-2: RF1, RF2: a C1-3 perfluoroalkylene group; RF3: a C1-6 perfluoroalkylene group; m: 0 or 1; and X: a hydrogen atom, an alkali metal atom, a fluorine atom, an alkyl group, ammonium or the like.

Abstract: The present disclosure provides methods, systems, devices, and kits for creating composite materials from a single resin, the composite materials having multiple continuous phases. The disclosure includes a process to three-dimensionally print objects (e.g., orthodontic appliances) with composite properties. In some aspects, the composite properties are formed from a single formulation with components that, when processed, have hard and soft continuous phases. In some aspects, the composite properties are formed by separately processing the hard phase components and the soft phase components. In some aspects, the composite materials and devices are three-dimensionally printed using the processed material.

Abstract: The present invention relates to an aqueous dispersion comprising core-shell polymer latex particles wherein the shell of the core-shell polymer latex particles bears ethylenically unsaturated groups pending from the polymeric backbone of the shell of the latex particles wherein the ethylenic unsaturation is separated from the polymeric backbone by at least 3 chemical bonds and wherein the shell of the core-shell particles is cross-linked and the core of the core-shell particles is not crosslinked, to a method for making the aqueous dispersion, to an elastomeric film made from the aqueous dispersion, to an article comprising the elastomeric film and to a method for making a self-supported elastomeric film from the aqueous dispersion.

Abstract: To provide a resin composition for plating and a plated molded article which are excellent in impact resistance and fluidity and which satisfy plating adhesion strength, plating deposition rate and thermal cycle resistance in a well-balanced manner.

Abstract: A build-up film with low dielectric loss, a preparation method therefor, and a circuit substrate structure are provided. The build-up film is prepared from raw materials including 5-10 parts by mass of monofunctional benzoxazine having indene oligomer, 40-65 parts by mass of polymerized aromatic-based maleimide, 30-50 parts by mass of allyl benzoxazine, 0.1-3 parts by mass of initiator, 250-400 parts by mass of inorganic filler, and 0.1-5 parts by mass of silane coupling agent. The build-up film has low dielectric loss and high tensile strength. Low dielectric loss enables it to be applied in the field of 5G. For example, the build-up film can be used to packaging integrated circuit substrates, which is conducive to minimizing the transmission loss.

Abstract: This invention relates to polyolefin. More specifically, this invention relates to polyolefin that has small copolymer content, but exhibits excellent mechanical properties.

Abstract: A neodymium-catalyzed modified conjugated diene-based polymer having excellent affinity with a filler is provided. A method for preparing the same and a rubber composition including the same are also provided. The neodymium-catalyzed modified conjugated diene-based polymer includes a repeating unit derived from a conjugated diene-based monomer; and a functional group derived from a modifier represented by Formula 1 in at least one terminal of a polymer.

Abstract: A devolatilizer (devo), which operates at a temperature (T) and at a pressure (P), for the separation of at least a portion of a solvent from a polymer-rich solution comprising the solvent and a polymer, and wherein the devolatilizer comprises at least the following components: A) a distributor, a heater, or a heater/distributor combination; B) a shroud (component B) located around some or all of the periphery of component A; and C) a gap (component C) located between the outer surface of component A and the inner surface of component B.

Abstract: A stable polyol pre-mix composition comprises a blowing agent, a polyol, a surfactant, and a catalyst composition comprising an oxygen-containing amine catalyst and a metallic salt. The oxygen-containing amine catalyst may be, for example, one or more of an alkanol amine, an ether amine, or a morpholine group-containing compound such as, for example, 2-(2-dimethylaminoethoxy)ethanol or N,N,N?-trimethylaminoethyl-ethanolamine. The metallic salt may be, for example, alkali earth carboxylates, alkali carboxylates, and carboxylates of metals selected form the group consisting of zinc (Zn), cobalt (Co), tin (Sn), cerium (Ce), lanthanum (La), aluminum (Al), vanadium (V), manganese (Mn), copper (Cu), nickel (Ni), iron (Fe), titanium (Ti), zirconium (Zr), chromium (Cr), scandium (Sc), calcium (Ca), magnesium (Mg), strontium (Sr), and barium (Ba).

Abstract: There is described a foamed isocyanate-based polymer derived from a reaction mixture comprising: an isocyanate; a polyol composition comprising a first prescribed amount of polymer particles dispersed in a base polyol; a second prescribed amount of biomass-based carbonaceous particulate material; and a blowing agent. In one embodiment, the foamed isocyanate-based polymer having an Indentation Force Deflection when measured pursuant to ASTM D3574-11 which is within about 15% as that of a reference foam produced by omitting the biomass-based carbonaceous particulate material from the reaction mixture and increasing the amount of polymer particles in the polymer polyol composition to equal the sum of the first prescribed amount and the second prescribed amount.

Abstract: A monomer composition, including: an acidic phosphoric acid ester (A); an amine-based catalyst (B); and a (meth)acrylate (E) having at least one of a urethane bond or a —NHC(?S)O— bond.

Abstract: The present invention generally relates to the field of curable resin compositions for cold flexible applications which are prepared from at least one monofunctional monomer and at least one urethane (meth)acrylate and which exhibit high performing coating properties over a broad range of service temperatures including temperatures in very cold conditions, methods for making these curable compositions and their uses.

Abstract: A curable resin represented by General Formula (1). In General Formula (1), R1 each independently represent a monovalent substituent (an alkyl group, an alkoxy group, a fluorine atom, and the like), m is 0 to 4, n is 0 to 40, and R2's are each independently a monovalent group including a polymerizable functional group.

Abstract: Disclosed are a modified epoxy resin immobilized enzyme, a preparation method therefor and an application thereof. Herein, the preparation method includes the following steps: modifying an epoxy resin, adding a polyethyleneimine to a modified epoxy resin for further modification, and then adding an enzyme to be immobilized and a glutaraldehyde for immobilization, to obtain the modified epoxy resin immobilized enzyme. The epoxy resin is modified, the polyethyleneimine is added to the modified epoxy resin for the further modification, and an aldehyde group in the resin and an amino group in the polyethyleneimine are covalently bound to each enzyme, then it is activated by the bifunctional reagent glutaraldehyde.

Abstract: Foam compositions are provided. The compositions are prepared from multi-functional acetoacetate esters and multi-functional amines or acrylates. The foam compositions can include one or more additives. The foam compositions can be used for home and commercial insulation, air sealing, sound proofing, structural improvement, and exterior roofing, among other applications. The foam compositions provide advantages of being isocyanate free and offer reduced exposure to isocyanate.

Abstract: A thermoplastic resin composition that contains, based on 100 mass parts for a total of (A) and (B), at least 20 mass parts but less than 50 mass parts of (A) a polyalkylene terephthalate resin and more than 50 mass parts and not more than 80 mass parts of (B) a polystyrene resin or a rubber-reinforced polystyrene resin, wherein an intrinsic viscosity (IVA) of the polyalkylene terephthalate resin (A) is 0.3 to 0.8 dl/g and a melt viscosity (?B) of the polystyrene resin or rubber-reinforced polystyrene resin (B) at 250° C. and 912 sec?1 is at least 80 Pa·sec.

Abstract: Disclosed is an eco-friendly biodegradable polyester resin composition, including: a polyester resin including a diol, an aromatic dicarboxylic acid and an aliphatic dicarboxylic acid, wherein an alternating ratio of the polyester resin is 0.3 to 0.7, wherein the alternating ratio is a ratio of a diol, bonded between the aromatic dicarboxylic acid and the aliphatic dicarboxylic acid, among the diol. The diol may include 1,4-butanediol; the aromatic dicarboxylic acid may include terephthalic acid or dimethyl terephthalate; and the aliphatic dicarboxylic acid may include adipic acid. When the biodegradable polyester resin composition is dried at 80° C., placed in a stainless steel mold, and compressed at 210° C. under a pressure of 10 MPa for 3 minutes to produce a polyester sheet having a thickness of 300 ?m, the sheet has a tensile strange range from 40 MPa to 60 MPa, an elongation at break range from 800% to 1100%, and Young's modulus range from 20 MPa to 80 MPa.

Abstract: Provided is a polyether ether ketone, comprising a repeating unit represented by the following formula (1), the polyether ether ketone having a crystallization temperature Tc of 255° C. or more, and satisfying one or both of the following conditions (A) and (B): (A) a fluorine atom content a is less than 2 mg/kg; and (B) a chlorine atom content b is 2 mg/kg or more.

Abstract: The invention relates to a process for producing semi-aromatic polyethers based on an aliphatic diol, to semi-aromatic polyethers based on an aliphatic diol obtained by said process, and to the use of said semi-aromatic polyethers based on an aliphatic diol for manufacturing membranes, manufactured parts and coatings.

Abstract: A capped bisphenol polyether oligomer including a reactive end group, wherein the capped bisphenol polyether oligomer further includes a repeating unit derived from: a bisphenol monomer, a benzylic dihalide, a tertiary cycloalkyl dihalide, or a combination thereof; and optionally, the capped bisphenol polyether oligomer further includes a branching agent.

Abstract: Ternary resin blends which can be cured in order to form a cured resinous material for use as a matrix in composite materials. The ternary resin blends comprise a polyfunctional cyanate ester, an asymmetric bisphenol-derived cyanate ester, and a compound of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification. A cured resinous material prepared by curing a ternary resin blend, a composite material comprising said cured resinous material, an article comprising said cured resinous material or said composite material, and methods for making the ternary resin blends, cured resinous materials, composite materials and articles are also disclosed.

Abstract: A poly(etherimide) includes repeating units derived from polymerization of a biphenol dianhydride and an organic diamine. A method of making the poly(etherimide) includes contacting the biphenol dianhydride and the organic diamine under conditions effective to provide a poly(etherimide). The poly(etherimide) can be useful in a variety of articles, for example in an optoelectronic component.

Abstract: A poly(amide-imide) copolymer that is a reaction product of a diamine represented by Chemical Formula 1, a diamine represented by Chemical Formula 2, a dicarbonyl compound represented by Chemical Formula 3, and a tetracarboxylic acid dianhydride represented by Chemical Formula 4, a composition for preparing the poly(amide-imide copolymer, and an article including the copolymer, e.g., a film are provided: wherein, in Chemical Formulae 1 to 4, Ra, L1, L2, n1, A, R3, X, R10, R12, R13, n7 and n8 are the same as defined in the specification.

Abstract: Aspects of the present disclosure relate to Schiff base oligomers and uses thereof. In at least one aspect, an oligomer is represented by Formula (I) wherein each instance of R4, R5, R6, R7, R8, R10, R11, R12, R13, and R14 is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, alkoxyl, aryloxyl, ether, and heterocyclyl. Each instance of R9 of Formula (I) is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, and ether. Each instance of R28 and R29 of Formula (I) is independently selected from the group consisting of hydrogen, alkyl, and aryl. Each instance of R33 of Formula (I) is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, and a bond. Each instance of R41 of Formula (I) is independently —NH— or a bond and each instance of R40 is independently —NH— or —NH—NH—.

Abstract: Aspects of the present disclosure relate to Schiff base oligomers and uses thereof. In at least one aspect, an oligomer is represented by Formula (IV) wherein each instance of R9 is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heteroaryl, and ether. Each instance of R28 and R29 of Formula (IV) is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, and aryl. Each instance of R33 of Formula (IV) is independently selected from the group consisting of alkyl, cycloalkyl, aryl, heterocyclyl, and a bond. Each instance of R41 of Formula (IV) is independently —NH— or a bond and each instance of R40 is independently —NH— or —NH—NH—. Each instance of R42 of Formula (IV) is independently —NH— or a bond and each instance of R43 is independently —NH— or —NH—NH—.

Abstract: Esters of polylactic acid, including polyethylene glycol esters of polylactic acid are disclosed. Exemplary esters of polylactic acid can be used as textile finishes. Methods of making the esters of polylactic acid via direct and transesterification reactions are also disclosed.

Abstract: A method for preparing a hydrogel includes forming a pre-gel comprising polymer and metal salt particles, unidirectionally-shrinking and dehydrating the pre-gel, and impregnating the unidirectionally shrunk and dehydrated pre-gel with an ion solution to crosslink and rehydrate the unidirectionally shrunk and dehydrated pre-gel to produce the hydrogel.

Abstract: A method of producing a thermoplastic starch by an in-situ reactive extrusion plasticization process and a method for preparing a starch/polymer blend by an in-situ reactive extrusion plasticization and compatibilization process. In the method, a plasticizer reaction precursor (or a plasticizing compatibilizer reaction precursor) is mixed with starch to adhere to the surface of the starch or enter the starch to break the intermolecular and intramolecular hydrogen bonds of the starch. Then a mixture of the plasticizer reaction precursor (or the plasticizing compatibilizer reaction precursor) and starch is subjected to extrusion to produce the thermoplastic starch (or the starch/polymer blend), where the reaction precursor undergoes an in-situ reaction on the surfaces of the starch and in the starch to form a macro-molecular plasticizer (or a plasticizing compatibilizer) to plasticize starch or provide plasticizing and compatibilizing effect on the starch/polymer blend.

Abstract: Provided is a glass fiber-reinforced resin molded article including low dielectric constant and particularly low dielectric loss tangent, in a high-frequency region of 10 GHz or more. The glass fiber-reinforced resin molded article contains glass fiber in the range of 10 to 90% by mass and a resin in the range of 90 to 10% by mass with respect to the total amount of the glass fiber-reinforced resin molded article. The glass fiber includes a composition including 52.0 to 59.5% by mass of SiO2, 17.5 to 25.5% by mass of B2O3, 9.0 to 14.0% by mass of Al2O3, 0.5 to 6.0% by mass of SrO, 1.0 to 5.0% by mass of MgO, 1.0 to 5.0% by mass of CaO, and 0.1 to 2.5% by mass of F2 and Cl2 with respect to the total amount of the glass fiber, and a number average fiber length is 1 to 10000 ?m.