Abstract: A method automatically characterizes a vascular access of a dialysis patient who is or was connected to a dialysis machine, the vascular access being characterized dependent on a recirculation rate.

Abstract: A perfusion system includes a fluid reservoir configured to hold a portion of fluid, the portion of fluid having a volume, the fluid reservoir having a total capacity that is greater than the volume; an imaging device, the imaging device configured to obtain image data corresponding to the fluid reservoir; and a controller. The controller is configured to receive the image data from the imaging device; determine the volume based on the image data; and facilitate control, in response to at least one of a user input and the determined volume of the portion of fluid, of an operating parameter corresponding to the fluid reservoir to facilitate changing or maintaining the volume of the portion of the fluid.

Abstract: An EBDLR system includes a multi-layered bio purifier having a plurality of layers. Each layer includes a membrane, a first type of cells on a first side of the membrane in a first channel, and a second type of cells on a second side of the membrane in a second channel. The EBDLR includes a plasma separator to receive blood from a subject and separate a plasma component from the blood, a first reservoir to collect the plasma component, and a second pump to move the plasma component from the first reservoir to the multi-layered bio purifier. The multi-layered bio purifier distributes the plasma component into the first and second channels of each layer to purify the plasma component. The EBDLR includes a second reservoir to collect the purified plasma component and a third pump to infuse the purified plasma component from the second reservoir into the subject.

Abstract: A blood reinfusion system for processing autologous blood for reinfusion into a patient. The system includes a blood reinfusion system having a blood processing canister with an internal fluid passageway. The internal fluid passageway includes a venturi region having a gravity-driven filtering system that is adapted to extract impurities from autologous blood without damaging the erythrocytes in the blood and, hence, inducing hemolysis of the erythrocytes in the blood, and loss of seminal native blood components, including native erythrocytes, platelets, white blood cells, plasma proteins and antibodies.

Abstract: An interlocking drug infusion device includes a drug reservoir, used for accommodating the drug to be infused, provided with a piston and a screw; a driving wheel, connected with the screw, driving the screw to push the piston forward by rotation; a driving unit, the driving unit moved in a driving direction to drive the driving wheel to rotate; an actuator, electrically connected to the driving unit, used to provide power for the driving unit in the driving direction after energized; a program module, electrically connected to the actuator, the program module providing a first driving instruction for controlling the actuator to perform periodic power output; and a position detection module, used to determine the periodic drug infusion amount. When the drug infusion amount reaches a preset threshold, the position detection module and/or the program module provide the actuator with a second driving instruction.

Abstract: A cradle securely mounts one or more infusion pumps to a pole without obstructing the display, buttons, or connector ports of the infusion pumps. A lower portion of the cradle includes connection pins sized/oriented to fit within respective connection holes of the infusion pump as well as an integrated strain relief mechanism for one or more cables. An upper portion of the cradle includes clamps for engaging a protrusion/ridge on a top surface of the infusion pumps. In a single cradle configuration, a recess within a back surface of the cradle mates with a pole clamp connector or a mounting bar in either a vertical or horizontal orientation. In a multiple cradle configuration, each cradle is secured indirectly to the pole clamp connector via a mounting bar and respective adapters. The mounting bar may be bent to introduce an offset between adjacent infusion pumps.

Abstract: A skin patch drug infusion device includes an infusion mechanism module, a driving unit, a power unit, a control mechanism module, a blockage detection module and an adhesive patch. The infusion mechanism module includes a reservoir used for accommodating the drug to be infused, a screw and a piston connected with the screw arranged inside. The driving unit is provided with driving wheel and driving end. The driving wheel is connected with the screw, and the driving end pushes the driving wheel to make the screw advance in the reservoir. The power unit connected with the driving unit is used for offering power for the driving unit. The control mechanism module is electrically connected with the infusion mechanism module. The blockage detection module operably connected to the control mechanism module includes a detection circuit and at least one detection element.

Abstract: A skin patch drug infusion device includes an infusion mechanism module, the infusion mechanism module includes: an upper case, a lower case, and a frame. The upper case is provided with multiple upper case engaging portions, and the lower case is provided with multiple lower case engaging portions, the frame is provided with multiple frame engaging portions engaged with the upper case engaging portions and lower case engaging portions; the lower case is further provided with a circuit board, while the circuit board is provided with a plurality of specific connection ends; the frame is provided with electrical connection terminals of specific components, and electrically connected the specific electrical connection ends on the circuit board to realize the internal circuit conduction of the infusion mechanism module. A control mechanism module, is electrically connected with the infusion mechanism module to regulate drug infusion.

Abstract: A skin patch drug infusion system includes an infusion mechanism module. The infusion mechanism module includes: a reservoir with a drug inlet and a drug outlet for accommodating the drug to be infused; an infusion needle with one end connected to the drug outlet of the reservoir. The other end is inserted subcutaneously implanting drug infusion. The skin patch drug infusion system includes: a control mechanism module, which works collaboratively with the infusion mechanism module to regulate drug infusion; an adhesive patch that attaches the infusion mechanism module and/or the control mechanism module to the skin surface; a filling module. The drug to be infused into the reservoir is filled via the drug inlet, the volume of the filling module is deliberately designed to be greater than the volume of the drug to be infused to ultimately reduce the risk of air being injected into the body.

Abstract: An infusion set includes a base (221) and a flexible catheter (242) movable from a first catheter position disposed substantially entirely within the base (221) to a second catheter position in which a free end of the catheter (242) is disposed externally of the base (221). An introducer needle (234) is located within the catheter (242) and is movable between a first introducer needle position disposed substantially entirely within the base (221) and a second introducer needle position in which a free end of the introducer needle (234) is disposed externally of the base (221). A spring (281) is activated to move the catheter (242) from the first to the second catheter position and the introducer needle (234) from the first to the second introducer needle position to facilitate insertion of the catheter (242).

Abstract: Systems and methods for driving electrical motors of medicament infusion pumps are disclosed. An infusion device for delivering a medicament to a body of a user can include a reservoir to contain medicament, a dispenser to cause medicament to be moved out of the reservoir, and a motor operably coupled to the dispenser. The motor can include a stator defining a central opening and a rotor removably disposed therein. A controller coupled to the stator is configured to (1) supply a first signal to the stator to cause the rotor to rotate in a first direction for a first rotational amount less than a full rotation; and (2) to then supply a second signal to the stator to cause the rotor to rotate in a second, opposite direction for a second rotational amount greater than the first, thereby causing medicament to be dispensed from the reservoir via the dispenser.

Abstract: An infusion pump is placed in a default mode in which a lower occluder valve is activated to compress a tubing loaded within the pump. While in the default mode, a downstream pressure sensor of the infusion device monitors for a lower force spike while the lower occluder valve is activated, and determines whether the spike is detected before the pump receives an indication to start an infusion of a fluid through the tubing. When the spike is detected, the pump is automatically configured to start the infusion. Otherwise, a warning is provided without starting the infusion.

Abstract: A system for compounding medications. The system includes one or more compounding devices, and a central computer system. The central computer system receives requests, at least some of which require the compounding of one or more medications, and pushes assignments of respective compounding tasks to the one or more compounding devices. The assignments are made in accordance with a set of rules designed to promote efficient use of compounding resources.

Abstract: The invention relates to a system comprising a cassette and an auto injector for delivery of medicament. The auto injector comprises an improved clutch functionality.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: An auto-injector for administering a dose of a liquid medicament includes an elongate housing arranged to contain a syringe with a hollow needle and a stopper for sealing the syringe and displacing the medicament, the housing having a distal end and a proximal end with an orifice intended to be applied against an injection site. The syringe is slidably arranged with respect to the housing. A spring capable of, upon activation: pushing the needle from a covered position inside the housing into an advanced position through the orifice and past the proximal end (P), operating the syringe to supply the dose of medicament (M), and retracting the syringe with the needle into the covered position. After delivering the medicament, an activator arranged to lock the spring in a pressurized state prior to manual operation and capable of, upon manual operation, releasing the spring for injection.

Abstract: The invention relates to a system comprising a cassette and an auto injector for delivery of medicament. The cassette for containing the medicament comprises an index ring.

Abstract: The invention relates to a system comprising a cassette and an auto injector for delivery of medicament. The system comprises an improved cap removal mechanism.

Abstract: The invention relates to a cassette for containing the medicament, wherein the cassette comprises an improved syringe holder lid ensuring that a syringe is maintained in the cassette.

Abstract: A pre-filled syringe (1) has a cap (14) which is snap-fastened/click-fitted onto the connecting tip (9) or the tubular body of the syringe, and inside which a breakable plug (13) is secured or connected. The plug is guaranteed to rupture when at least one portion of the cap is twisted about the longitudinal axis (X) of the syringe.

Abstract: A ring for facilitated aspiration of a syringe is provided. The ring is preferably worn on the thumb of a user, but may be used on other fingers. An opening slot is located along the perimeter of the ring. The opening slot has a curved passageway, formed by the first end and the second end of the ring being curved. The opening slot secures a portion of a syringe. A v-shaped slit on the second end of the ring receives and secures various sized syringes.

Abstract: A prefilled syringe containing a sterile ophthalmic pharmaceutical composition comprising an ultraconcentrated hydrogel and a pharmaceutically acceptable carrier, the prefilled syringe capable of storing the ultraconcentrated hydrogel and injecting the ultraconcentrated hydrogel with a reduced injection force into a biologic tissue.

Abstract: A device for administering a fluid product includes a first housing part with a receiver for the product, a second housing part detachably connectable to the first housing part, a piston rod held such that it can be displaced for the exertion of an emptying movement, an actuatable or releasable drive element for the piston rod, a coupling element including a coupling input element that couples the drive element to the piston rod in a coupling engagement, transmits a driving force of the drive element to the piston rod, and triggers the emptying movement, and a decoupling element displaceably connected to the second housing part and coupled to the first housing part such that it is displaced, by a movement of the housing parts in relation to each other when the housing parts are separated into a decoupling position wherein the piston rod is decoupled from the coupling input element.

Abstract: A needle shield assembly comprises an elongate needle shield comprising a shield portion, a hub connection portion and a bridge portion including a living hinge having a thickness, the bridge portion joining the hub connection portion and the shield portion, the hub connection portion comprising a receiving ring having a diameter sized to frictionally receive the hub outer surface when the needle assembly is inserted through the receiving ring and a flange extending from the receiving ring defining a top planar surface and a bottom surface. The thickness of the flange divided by the thickness of the living hinge defines a ratio of from 1.1 to 6. The shield portion is configured to pivot from an open position in which the needle cannula is exposed, to a closed needle protecting position in which the distal end of the needle cannula is within the longitudinal opening of the shield.

Abstract: A device for conveying a local cryoanesthesia type painless syringe, the device includes: a first needle guide hole formed at the center of a skin anesthetizing plate, a second needle guide hole formed at the center of a Peltier element, a third needle guide hole formed at the center of a heat dissipation block, a fourth needle guide hole formed at the center of a first heat dissipation plate, a support clip, configured to loosely clamp one side of a syringe cylinder, formed at an upper side of a moving stand to allow a syringe needle coupled to the syringe cylinder to be positioned on a center line of the fourth, third, second, and first needle guide holes, a moving stand conveyor configured to move the moving stand toward the skin to convey the syringe cylinder so that the syringe needle of the syringe cylinder is able to pass through the fourth, third, second, and first needle guide holes and be inserted at a predetermined depth into the skin, a moving clip in which an insertion groove is formed to, unlike

Abstract: A distraction device configured to be used with a needle device for insertion into tissue includes a body attached to the needle device; and a member extending from the body, wherein the member includes a distractor tip proximal to a needle tip of the needle device. In use, the distractor tip is configured to contact a tissue surface before and during insertion of the needle tip into the tissue surface.

Abstract: The present disclosure generally relates to medicament delivery devices such as autoinjectors, and particularly concerns pads for attaching medicament delivery devices such as autoinjectors to an injection site.

Abstract: Autoinjectors comprising an energy source mechanism, a damping mechanism and a delivery mechanism with a formulation that is to be delivered to a subject in need thereof are described. Also described are damping mechanisms that, in addition to other advantages, reduce the initial force and pressure spikes when energy is released from the energy source.

Abstract: A safety warning system for detecting glucose in an arterial monitoring or flush system is disclosed. An example of the system comprises a receptacle configured to receive fluid from a line for connecting to a patient, and an indicator arranged to contact the fluid and configured to provide an indication of whether the fluid comprises glucose. The receptacle comprises a gas release path to enable the fluid to displace gas to contact the indicator.

Abstract: A receptacle section for an aerosol provision article is described. The aerosol provision article is for generating a flow of aerosol in use. The receptacle section is arranged for receiving therein an activatable element for modifying, once activated, a property of the flow of aerosol. The receptacle section includes at least one activating element operable to apply, after an installation of the activatable element in the receptacle section by a user, a force to the activatable element to activate the activatable element installed in the receptacle section in use.

Abstract: A multifunctional atomization device includes a housing, an atomization module and an integrated module. The housing is provided with a storage cavity and an atomization cavity, the storage cavity is configured to store an atomized liquid, an end of the atomization cavity away from the storage cavity is provided with an air outlet communicating with an exterior of the housing, the housing is further provided with a gas channel, one end of the gas channel communicates with the exterior of the housing, and another end of the gas channel communicates with the atomization cavity. The atomization module is disposed within the atomization cavity and is configured to atomize the atomized liquid. The integrated module is disposed within the atomization cavity, and a blood oxygen detection unit, a heart rate detection unit and a gas composition detection unit are integrated on the integrated module.

Abstract: A droplet delivery device including a face seal within a cover of the droplet delivery device to seal over an ejector mechanism when the cover couples to a mouthpiece.

Abstract: An apparatus includes a first member coupled to a second member. The first member defines a chamber containing a dry powder and includes a chamber wall that forms an outer boundary of the chamber. The second member includes a surface covering the chamber and defines an intake channel and an exit channel. The exit channel is fluidically coupled to the chamber via an exit opening. The intake channel is fluidically coupled to the chamber via an intake port. A center line of the intake channel is tangential to a portion of the chamber wall such that a portion of an inlet airflow conveyed into the chamber via the intake channel has a rotational motion. The intake port is defined at least in part by an intake ramp. The intake ramp includes a transition surface that forms an exit angle with respect to the surface of less than 105 degrees.

Abstract: A medication inhalation device comprises a housing (10) movable between a collapsed state and an expanded state. In the expanded state the housing defines a volume for mixing a medication delivered from a medication delivery device and air. In the expanded state the housing (10) comprises: external walls (11), (12), (13), (14) that define the volume, a first end (15) with an inlet opening (18) for delivering the medication to the volume, and a second end (16) with an outlet opening (19). A mixture of air and medication can be inhaled from the volume by the user. The second end (16) is convertible between a mouthpiece configuration and a mask configuration.

Abstract: An electronic vapor provision device comprises a body and a vaporizer. The body comprises a power cell and a processor, and the vaporizer is releasably connectable to the body. The processor is configured to enter a sleep mode when the vaporizer is connected to the body and the device is inactive for an inactive time. Furthermore, the processor is configured to leave the sleep mode and enter a usable mode when the vaporizer is disconnected from the body then reconnected to the body.

Abstract: The present disclosure may provide an atomizer and an electronic atomization device. The atomizer may include a shell, a heating assembly, a lid, a base, and a first sealing component. The shell defines a liquid cavity and a smoke outlet. The heating assembly may heat and atomize the liquid into a smoke. The lid and the base may be provided to fix the heating assembly therebetween. The lid defines a liquid inlet communicating with the liquid cavity, and the liquid may flow through to reach the heating assembly. The atomizer may define an air entering hole, such that external air may enter the device through the hole to drive smoke to flow. The first sealing component may be engaged between the lid and the heating assembly, contacting both at the same time and defining air guiding channels to guide the air to flow into the liquid cavity.

Abstract: An inhalation component generating device includes: a power supply; a load that evaporates or atomizes an inhalation component source by power from the power supply; and a control circuit that performs control based on an output of a temperature sensor. The control circuit performs: a process (a) of calculating power supply temperature on the basis of the output of the temperature sensor; and a process (b1) of determining whether the power supply temperature is in a first temperature range, and performing deterioration diagnosis on the power supply only in a case where the power supply temperature is in the range.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

Abstract: The invention relates to a calibration device (2) for calibrating the measuring means (120-122) of an NO delivery apparatus (1), comprising a gas intake line (22) comprising, arranged in series, a valve, preferably manual (23) and actuatable by a user, for controlling the circulation of gas in the gas intake line (22); a precision regulator (24) configured to deliver a predefined fixed pressure in the gas intake line (22); a calibrated orifice device (25), and a venturi device (26). The measuring means of the NO delivery apparatus comprise an NO sensor, an NO2 sensor and an O2 sensor.

Abstract: A portable tracheobronchial-air stimulation device intended to be connected to a subject including a physiological interface; a vacuum interface, the vacuum interface including a safety element; a vent; an electro-valve; and a control module configured to control the electro-valve Also, a method for stimulating tracheobronchial-air, which uses the portable tracheobronchial-air stimulation device.

Abstract: Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system.

Abstract: A mechanical ventilator closed loop control system, methods, and apparatus are disclosed. In an example, a mechanical ventilator performs a respiratory treatment for a patient according to respiratory treatment settings, which include at least one ventilation mode. During the treatment, the mechanical ventilator receives and/or determines physiological parameter values from one or more physiological sensors. The physiological parameters may be patient neurological parameters, metabolic parameters, circulatory parameters, and/or respiratory parameters. The mechanical ventilator uses one or more closed loop control algorithms and the physiological parameter values to determine at least some of the respiratory treatment settings and/or the ventilation mode is to be adjusted. After making the determination, the mechanical ventilator adjusts the respiratory treatment so that the treatment reflects a current health status of the patient.

Abstract: The present disclosure relates to a tracheostomy exchange system including a catheter comprising a distal end and a proximal end, a balloon fluidly coupled to the distal end of the catheter, and an adapter assembly removably coupleable to the catheter and configured to fluidly couple the balloon with the proximal end of the catheter when the adapter assembly is coupled to the catheter. When the adapter assembly is decoupled from the catheter, the balloon is fluidly sealed from the proximal end of the catheter. When the is inflated before the adapter assembly is decoupled from the catheter, the balloon can remain inflated while the tracheostomy is exchanged preventing aerosolization, protecting the lungs from bleeding and aspiration, allowing for effective oxygenation while preserving an access to the main airway.

Abstract: A user interface comprising a non-sealing nasal cannula and a mask arranged about the nasal cannula, the mask including a seal configured with a user's face to allow the interface to be pressurised, the cannula configured to deliver breathing gases to the nares of a user at a flow rate exceeding the intended user's peak inspiratory flow requirements so that the mask and the user's pharynx are flushed continuously with fresh breathing gases to reduce dead space.

Abstract: Disclosed is a headgear for a patient interface, where the headgear includes a first and second lapped panels. The lapped panels define a lapped region in which the first and second panels respectively overlap and underlap each other. The lapped panels also define a non-lapped region in which the first panel is not lapped. At the lapped region, adjacent surfaces of the respective lapped panels are fused together.