Abstract: A centrifugal fan for a heating, ventilation, air conditioning, and refrigeration (HVACR) system is disclosed. The centrifugal fan includes a volute housing having an inner surface and a curved inlet shroud. The volute housing defines an air outlet. The curved inlet shroud defines an air inlet. The air inlet has an inlet airflow cross-sectional area that lies substantially perpendicular to an outlet airflow cross-sectional area of the air outlet. The centrifugal fan also includes an impeller mounted for rotation about a rotational axis within the volute housing. The impeller has a plurality of fan blades. The plurality of fan blades has an outer surface. The centrifugal fan further includes a light source. The inner surface of the volute housing and the outer surface of the plurality of fan blades includes a photocatalyst layer. The light source is configured to emit light on the photocatalyst layer.

Abstract: Disclosed herein are improved devices, systems, and methods for the expression and collection of breast milk, such as human breast milk. A breast shield assembly for expression of breast milk may comprise a breast interface and an actuatable assembly interface fluidly coupled with a tube, wherein the breast interface is configured to engage the breast and the actuatable assembly interface is configured to removably couple to an actuatable assembly. The breast shield assembly may comprise an enclosed fluid reservoir extending between the breast interface and the actuatable assembly interface, the fluid reservoir physically separated from the expressed breast milk and filled with a driving fluid comprising a liquid. The breast shield assembly may further comprise a fill port configured to allow addition or removal of the driving fluid to or from the fluid reservoir.

Abstract: A hemodialysis system including one or more ultraviolet chambers is disclosed. The hemodialysis system including a dialyzer arranged and configured to filter a patient's blood, a hemodialysis machine arranged and configured to pump, move, or the like dialysate through the dialyzer, the hemodialysis machine including an outlet valve and an outlet fluid flow path to pump or move dialysate from the hemodialysis machine to the dialyzer, and an inlet valve and an inlet fluid flow path to pump or receive dialysate from the dialyzer, and one or more ultraviolet chambers arranged and configured to kill bacteria, viruses, or a combination thereof. Thus arranged, by incorporating one or more ultraviolet chambers in strategic areas of the system, the ultraviolet chambers may eliminate, or at least greatly reduce, the possibility of cross-contamination in, for example, the dialysate, and thus eliminate the need for disinfecting the system between treatments.

Abstract: Systems, methods, and devices are provided for the treatment of edema. In one aspect a method for implanting an indwelling catheter within a vein of a patient is provided. The catheter can extend from a position upstream of at least one outflow port of a duct of the lymph system to a terminal position downstream of the at least one outflow port. In use, a first restriction can be created within the vein proximal to a distal region of the catheter. The first restriction can define a localized low pressure zone distal of the restriction and within a portion of the vein housing the catheter. The low pressure zone can be adjacent to the at least one outflow port to enable fluid to pass from the at least one lymph duct outflow port into the vein.

Abstract: A method for damaging viruses in a human tissue comprised generating a series of ultra-short pulse laser (USPL) pulses by a USPL generator, radiating the USPL pulses by a USPL applicator and exposing the human tissue to a defined number of generated USPL pulses wherein an energy absorbing enhancing substance is disposed between the human tissue and the USPL applicator.

Abstract: Embodiments of a negative pressure wound therapy systems and methods for operating the systems are disclosed. In some embodiments, a system includes a pump assembly, canister, and a wound dressing configured to be positioned over a wound. The pump assembly, canister, and the wound dressing can be fluidically connected to facilitate delivery of negative pressure to a wound. The pump assembly can present graphical user interface screens for controlling and monitoring delivery of negative pressure. The system can be configured to efficiently deliver negative pressure and to detect and indicate presence of certain conditions, such as low pressure, high pressure, leak, canister full, and the like. Monitoring and detection of operating condition can be performed by measuring one or more operational parameters, such as pressure, flow rate, and the like.

Abstract: A flushing and aspirating device includes a device housing with an aspirating channel, a flushing channel, a flushing and aspirating channel and a valve chamber in which the channels empty or emerge therefrom, respectively. A manually operable valve push button is movably guided in the valve chamber against the force of a reset spring and which has at least one sealing section for controlling the connection of the flushing and aspirating channel to the aspirating channel and/or the flushing channel. The valve push button including the at least one sealing section is formed as a single piece of an elastic rubber material, such as silicone.

Abstract: An improved percutaneous endoscopic gastrostomy (PEG) tube that allows continuous suctioning/sumping without occlusion of the tube by the gastric wall. The PEG tube includes a hollow drainage tubing coupled to a ventilated bell cap. The bell cap can be open or closed to the external environment is ventilated via apertures, crenellations and grooves, and hemispherical arches. The PEG tube minimizes, or completely eliminates, the need for a user thereof to frequently flush the tube, thus also curtailing intermittent suctioning and allowing for longer periods of uninterrupted drainage. Furthermore, the PEG tubes of the current invention reduce clogging of the tube by larger gastric matter that is intended to be suctioned out of the patient or subject.

Abstract: A portable system for subatmospheric pressure therapy in connection with healing a surgical wound, includes a wound dressing dimensioned for positioning relative to a wound bed of a subject, a portable subatmospheric pressure mechanism dimensioned to be carried or worn by the subject and a container for collecting exudates from the wound bed removed under the subatmospheric pressure supplied by the subatmospheric pressure mechanism. The portable subatmospheric pressure mechanism includes a housing, a subatmospheric pressure source disposed within the housing and in fluid communication with the wound dressing to supply subatmospheric pressure to the wound dressing and a power source mounted to or within the housing for supplying power to actuate the subatmospheric pressure source.

Abstract: An electronic vaporizer is provided. The electronic vaporizer includes a cartridge that facilitates provision of a vaporized solution to an individual. The cartridge includes a housing that includes an interior, wherein the housing is one of a polymer housing or a ceramic housing. The cartridge also includes a heating element located in the interior of the housing, wherein the heating element is configured to vaporize a solution for oral provision to the individual. The vaporizer may also include a power harvesting device operative to acquire energy from the environment for use with powering the heating element.

Abstract: A system for performing an endoscopic surgical procedure in a surgical cavity of a patient that includes a gas delivery device configured to deliver a flow of pressurized gas to a gas delivery lumen extending therefrom, a gaseous sealing module communicating with a distal end of the gas delivery lumen and configured to generate a gaseous seal within a gas sealed lumen extending therefrom, and an access port communicating with a distal end of the gas sealed lumen so as to provide sealed instrument access to the surgical cavity and maintain a stable pressure within the surgical cavity.

Abstract: A carrier assembly for a spray device, which carrier assembly comprises a carrier member adapted to be mounted in a cartridge adapter of a spray device, which carrier member has a proximally directed first surface, and a through-hole placing the first surface in fluid communication with the second surface; a micro nozzle having an outlet surface, an inlet surface, and a channel placing an inlet orifice at the inlet surface in communication with an outlet orifice at the outlet surface and wherein the micro nozzle is accommodated and attached to the carrier member such that the outlet orifice is aligned with the through-hole, and wherein the carrier member comprises vent holes formed to allow air to flow between the second surface and the first surface.

Abstract: An aerosol-generating device is provided, including: a housing defining a mouthpiece end, a distal end, a sidewall between the mouthpiece end and the distal end, and a chamber within the housing, the chamber being configured to receive a liquid container, the housing including a retainer configured to retain the liquid container within the housing, the retainer including a magnetic retention mechanism; and a power source disposed within the housing, the sidewall of the housing defining an insertion window through which the liquid container is positionable inside the chamber. An aerosol-generating system and a liquid container are also provided.

Abstract: An aerosol-generating system may include a liquid storage portion configured to hold aerosol-forming substrate, a vaporizer, and a pump. The liquid storage portion includes a movable wall and an outlet. The vaporizer includes a heating element having a structure that at least partially defines an internal passage. The pump may deliver liquid aerosol-forming substrate from the outlet of the liquid storage portion to the internal passage of the heating element. The pump may include a micro stepper motor with a drive shaft that is configured to rotate a particular amount based on performing an individual step, a piston connected to the movable wall, and a lead screw connecting the drive shaft to the piston and configured to translate rotation of the drive shaft into axial movement of the piston and the movable wall. The vaporizer may at least partially vaporize the delivered liquid aerosol-forming substrate.

Abstract: Disclosed are an apparatus and a method for monitoring the disconnection of a patient interface system during the ventilation, in which values which are indicative for the time curve of the respiratory gas flow are established and subjected to data evaluation, and wherein an alarm is triggered on the basis of the data evaluation if at least one value which is indicative for the time curve of the respiratory gas flow deviates from a specific limit value for a specific period of time.

Abstract: A respiratory ventilation apparatus configured to deliver a respiratory gas to a patient interface is provided. The apparatus may include a gas pressurization unit configured to generate a pressurized respiratory gas, a gas inlet port configured to introduce the respiratory gas into the respiratory ventilation apparatus, a gas outlet port configured to discharge the pressurized respiratory gas to a respiration tube, a detection module configured to detect the pressure of the pressurized respiratory gas, at least one non-volatile memory configured to store a plurality of parameters and a plurality of programs, and one or more controllers. The one or more controllers may be configured to initiate the respiratory ventilation apparatus upon a boot operation, and/or initiate a program that constantly reads information from the detection module, and controls the pressure of the pressurized respiratory gas using the information read from the detection module and at least one parameter.

Abstract: A respiratory assistance device including a respiratory interface device configured to be worn by a user and deliver a gas, a gas temperature measurement unit configured to measure a gas temperature that is a temperature of the gas, a warming unit configured to warm the gas, and a temperature change unit configured to change the gas temperature by controlling the warming unit. The respiratory assistance device can administer comfortable respiratory assistance even during sleep.

Abstract: A paediatric tracheostomy tube is provided in two parts. One part is a patient end portion (13) having a silicone shaft (10) arranged to locate in the trachea. The machine end is formed with a mounting flange (20) adapted to lie against the neck and has a low profile coupling (21) on its machine side. The other part is a machine end portion (23) having a flexible, corrugated shaft (10?) of polypropylene with a low profile coupling (26) at its patient end adapted to engage the coupling (21) on the flange as a twist fit. The machine end of the machine end portion (23) has a tapered male coupling (25) adapted to fit with a female coupling on a breathing tube, the male coupling having a larger profile than the coupling (26) on the patient end of the machine end portion (23) and the coupling (21) on the flange.

Abstract: A securement device for a protruding oral or nasal device includes a continuous strip extending along a longitudinal axis between a first end and a second end. The continuous strip has a first anchor portion at the first end, a second anchor portion at the second end, a first bridge portion, a second bridge portion, and an adhesive for affixing the strip to a patient. The first bridge portion is disposed between the first anchor portion and the second bridge portion, the second bridge portion is disposed between the first bridge portion and the second anchor portion, the second bridge portion extends at an angle relative to the longitudinal axis. The first anchor portion and the second anchor portion are offset from one another relative to the longitudinal axis.

Abstract: Interfaces for positive pressure therapy having a mask assembly, a headgear assembly and a connection port assembly are disclosed herein. The connection port assembly has a ball joint connection with the mask assembly and includes a quick release button for easily disconnecting the gases source conduit from the mask assembly. The mask assembly may include a bias flow vent that is formed separately and attached to the mask assembly. The headgear assembly encircles the rear region of the user's head and may include at least some portions that are substantially non-stretchable.

Abstract: A patient interface including a seal-forming structure with an elastomeric membrane that has at least one hole such that the flow of air at a therapeutic pressure is delivered to at least an entrance to the patients nares and/or an entrance to the patients mouth. The seal-forming structure is constructed and arranged to maintain the therapeutic pressure in a cavity of a plenum chamber throughout the patients respiratory cycle, in use. The elastomeric membrane includes a first portion that is held in a relaxed state and a second portion that is held in a taut state. The elastomeric membrane is molded to include a three-dimensional shape that has multiple curvatures. The at least one hole includes an arch on a lateral side of the at least one hole, and is in a relaxed state before use. The arch is configured to move to a substantially taut state during use.

Abstract: An integrated cannula with interface pillows includes a cannula section having a gas inlet for receiving gas, exhalation holes for venting exhalation gas to the atmosphere, and nubs for attaching a head strap. There are two interface pillows formed from a pliable material extend from the cannula section. Each of the interface pillows having an insertion tip that is distal from where each of the interface pillows meets the cannula section. An insertion bulge extends from each interface pillow between the insertion tip and the cannula section, limiting an insertion distance of the insertion tip. An insertion area of each interface pillow extends between the insertion bulge and the insertion tip during use, the insertion bulge is configured to seal against an outer edge of the nostril of a nose.

Abstract: A patient interface system for delivery of a supply of air at positive pressure to the entrance of a patient's airways for treatment of sleep disordered breathing includes an air delivery tube connected to a flexible portion of a plenum; a vent structure having sufficient rigidity to support its own weight under gravity and/or not to block or fold under tube movement or tube drag; and a patient interface structure. The patient interface structure includes a seal forming structure arranged on a top portion of the plenum; and a seal positioning and stabilizing structure connected to a flexible portion of the plenum. The seal-forming structure is substantially decoupled from a tube drag force.

Abstract: This invention relates to connectors to be provided into fluid communication or engagement either directly with, or via a component to be associated with, a terminal end of a breathing conduit. In at least one embodiment, the connector comprises a body having a first end and a second end, and an internal lumen for the passage of gas between the ends. The first end engageable with a terminal end of a conduit or a component to be associated therewith. The second end engageable with another connector. An internal surface of the body at the second end comprises internal connection features for connection with another connector to be received internally therein. An external surface of the body comprises one or more external alignment feature(s) for aligning the connector or another connection into an aligned orientation for connection therebetween.

Abstract: Storage device for a guide wire or dilation balloon including a tank, and a frame including two walls forming between them an internal volume and including an insertion aperture. The frame includes an opening passing through the frame from one wall to the other, and a slot formed in the internal volume and communicating with the insertion aperture, the slot opening into the opening over part of its perimeter, referred to as open part. The tank includes a positioner configured to place the frame in a stowage position in which the open part of the slot is situated at least partly inside the tank and the insertion aperture extends outside the tank, the tank further including a stop configured to block the translational movement of the frame in directions of insertion and extraction of the guide wire or of the dilation balloon into and out of the frame.

Abstract: A storage apparatus is provided for storage of elongate articles in a vertical orientation, such as for storage of flexible esophageal dilators. The storage apparatus includes a gripping element of flexible material supported at a support frame. The gripping element includes receiving slots or apertures aligned with the spaced holes in the rigid panel. The support frame may include a rigid support panel with a pattern of spaced holes corresponding to respective ones of the receiving apertures of the gripping element. The gripping element grips and holds elongate articles at respective receiving apertures to suspend the articles in a vertical orientation. The elongate articles are retained in the gripping element until a user exerts a removal force on the article to retrieve it from the storage apparatus. The support frame may be disposed inside of a container, such as a cabinet or drawer.

Abstract: A system of devices for treating an artery includes an arterial access sheath adapted to introduce an interventional catheter into an artery and an elongated dilator positionable within the internal lumen of the sheath body. The system also includes a catheter formed of an elongated catheter body sized and shaped to be introduced via a carotid artery access site into a common carotid artery through the internal lumen of the arterial access sheath. The catheter has an overall length and a distal most section length such that the distal most section can be positioned in an intracranial artery and at least a portion of the proximal most section is positioned in the common carotid artery during use.

Abstract: The present disclosure is directed to a device that can be in the form of a sleeve that has a first upper portion and a second lower portion. The first upper portion can include exit ports to allow various catheters, such as peripherally inserted central catheter (PICC) lines, to extend through openings therein. The second lower portion is inverted upwardly over the first portion and can have a securement flap on an outer surface to tighten around the patient's arm and around the PICC line to ensure that the PICC line and the sleeve remain stationary relative to the patient's arm.

Abstract: A catheter assembly includes a flexible catheter (22), a needle (12) having a sharp distal tip, the needle (12) disposed in the flexible catheter (22) and moving from a first position that exposes the needle (12) to a second position, an outer member (26) that is configured to engage and disengage a catheter hub (14), an inner member (28) disposed in the outer member (26), and a needle protection (30) member disposed in the inner member (28), the needle protection member (30) enclosing at least a portion of the needle (12) when the needle (12) is in the second position.

Abstract: A guide wire includes a first core shaft, a second core shaft, a first tubular member, and a second tubular member. The first tubular member is disposed to cover (i) a contact portion where the first core shaft and the second core shaft are arranged opposite to each other so that their central axes coincide, and (ii) a part of each of the first core shaft and the second core shaft, the part being adjacent to the contact portion. The second tubular member, having a tubular shape, covers at least the first tubular member and is fixed to both the first core shaft and the second core shaft.

Abstract: The present disclosure relates to guidewire devices having shapeable tips and effective torquability. A guidewire device includes a core having a proximal section and a tapered distal section. A tube structure is coupled to the core such that the tapered distal section of the core extends into and distally beyond the tube structure. The portion of the core extending distally beyond the tube forms a shapeable tip. A polymer covering encompasses the tip. The tip is configured to reduce the tendency of resilient forces from the tube structure to disrupt a customized shape of the tip.

Abstract: The present disclosure is directed to a device. The device may include a distal shaft defining a central lumen and an orienting element comprising at least one inflatable member. Wherein a first portion of the orienting element extending from the shaft in a first direction and a second portion of the orienting element extending from the shaft in a second direction. Further, wherein the second direction is substantially opposite the first direction.

Abstract: Devices used to pressurize, depressurize, or otherwise displace fluid are disclosed. The devices may be configured to displace fluid in order to inflate or deflate a medical device, such as a balloon. The devices include a trigger configured to convert the devices from a pressurization state to a priming state. The devices further include a locking or toggle member configured to toggle and/or maintain the devices in a priming state.

Abstract: Sensor devices and methods of operating for use with catheter-based treatments of microcardial microvascular obstruction by infusion of fluids having protective agents into vasculature are provided herein. Such catheter devices can include a first lumen configured for advancement over a guidewire and for passage of fluid having protective agents after removal of the guidewire and a second lumen for inflation of an angioplasty balloon and can further include a temperature and/or pressure sensor mounted on the catheter body. Such catheter devices can further include use of a distal occlusive membrane between the angioplasty balloon and distal end to facilitate infusion into microvasculature. The occlusive membrane can be deployed by relative movement of concentric channels, thereby reducing the need for additional lumen while optimizing the size of the catheter device and lumens.

Abstract: Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.

Abstract: A system for cleansing wounds with a fluid jet includes a pressure pump (900) for generating a fluid jet, a handpiece body (200) with a nozzle (204) for emerging the fluid jet, a fluid line (90) connecting the pressure pump (900) with the handpiece body (200), an adapter (700) holding a porous body (510), the adapter (700) being releasably connected to the handpiece body (200). The adapter (700) and the porous body (510) comprise a free inner space (770, 570) into which the fluid jet emerges when leaving the nozzle (204). The adapter (700) is at least partially transparent, thereby enabling a view into the inner space of the adapter and the porous body. The system according to the invention combines the advantages of cleansing by a fluid jet with the advantages of mechanical cleansing and, at the same time, provides effective protection against aerosols.

Abstract: Devices and methods for delivering an ingestible medicament of a medicament tablet into the gastrointestinal tract of a user. A device according to the invention includes a vibrating ingestible capsule and a hollow medicament compartment housing. The vibrating capsule includes a housing, a vibrating agitation mechanism disposed within the housing, a power supply, and a control element. The hollow medicament compartment housing is associated with the housing of the capsule and includes at least one aperture. The hollow of the medicament compartment housing is configured to have the medicament tablet disposed therein. The aperture(s) are dimensioned to enable fluid communication the surrounding environment and the hollow.

Abstract: This disclosure includes wound dressings and systems for effluent management of topical wound therapy and related methods. Some devices, which are configured to dilute therapeutic gas effluent flowing from a dressing, comprise a therapeutic gas source configured to provide therapeutic gas to the dressing; a container comprising a sidewall that defines a chamber configured to receive therapeutic gas effluent from the dressing; a negative pressure source configured to be coupled to the container such that the negative pressure source can be activated to draw fluid from the dressing through the chamber of the container; and a diluent gas source configured to deliver a diluent gas to dilute therapeutic gas effluent before the therapeutic gas effluent enters the negative pressure source.

Abstract: Embodiments of the present disclosure relate to encapsulation devices, systems and methods of use. In some embodiments, encapsulation devices for housing cells and providing various therapeutic benefits to a patient or host are described. Encapsulation devices include, for example, a matrix or scaffold within a cell-receiving area or void. Encapsulation devices may include channels that are operable to convey fluid to internal areas of devices without restricting vascularization.

Abstract: There is disclosed systems and methods for non-invasive delivery of an agent to biological tissues. Delivery of the agent to the tissues can be by one or more modalities. In some embodiments the systems and methods use agent carrier body including a tissue contacting surface for non-invasively engaging tissues under treatment. The tissue contacting surface can be at least partly defined by a plurality of protrusions that are in fluid communication with one or more reservoirs forming part of the agent carrier body. The protrusions may extend outward from an inside of a void and terminate at said tissue contacting surface.

Abstract: Disclosed herein are embodiments of a connector system for releasably connecting together tubes, for example medical tubing, and methods of making and using such a connector system, whereby the connector system includes a female coupler having a first passageway, a male coupler having a second passageway, a catch movably coupled to the female coupler, and a catch-receiving element coupled to the male coupler. The connector system further includes a release element movably coupled to the female coupler, whereby travel of the release element along or over a female coupler outer surface of the female coupler disengages the catch from the catch-receiving element to achieve a disconnected condition of the connector system. Further disclosed herein are embodiments of a connector system for releasably connecting together tubes, whereby the connector system includes at least one valve biased by a valve-biasing member disposed external to or outside of the fluid flow path.

Abstract: A drug delivery system for injecting a medicament includes a housing defining a cavity, a container received within the cavity and configured to receive a medicament, the container comprising a stopper configured to move within the container and a closure, a drive assembly received within the cavity and configured to drive the stopper within the container, a needle actuator assembly received within the cavity and comprising a needle configured to be placed in fluid communication with the container, the needle moveable from a first position and a second position spaced from the first position, and a sterilizer received within the cavity and configured to sterilize at least one of the container, the drive assembly, and the needle actuator assembly upon activation of the drug delivery system.

Abstract: A packaging assembly comprises a case configured to contain a plurality of injection devices for delivering a medicament and a lid coupled to the case. The lid is movable between an open position and a closed position. The packaging assembly further includes a countdown timer configured to monitor a time remaining to a scheduled time and a sensor configured to output a signal representative of a change in position of the lid from the closed position to the open position. The packaging assembly also includes a reminder alert configured to activate once the scheduled time has been reached, and deactivate based on the signal received from the sensor. The packaging assembly further comprises a reset input device. The packaging assembly is configured to respond to operation of the reset input device by a user to set the scheduled time.

Abstract: Aspects of the present disclosure provide systems, devices, and methods for delivering substances such as fluids, solutions, medications, and drugs to patients using infusion devices having a set of advanced features. These advanced features include aspects related to the programming of infusion devices, the configuration of infusion sequences performed by the infusion devices, and the interconnection of multiple infusion devices for interoperation during an infusion having a sequence of infusion steps.

Abstract: Certain embodiments provide multi-medicament infusion systems for preventing the cross-channeling of medicaments. The system may include one or more of an infusion pump, medicament cartridges, cartridge connectors, a multi-channel fluid conduit, and an infusion set. The infusion pump can have an inductively chargeable battery assembly that can be charged by an inductive charging pad.

Abstract: Disclosed herein are techniques related to interactive guidance for medical devices. The techniques may involve identifying, by an application executing on a computing device, a user objective with respect to a medical device communicatively coupled to the computing device. The techniques may further involve obtaining state information for a current state of a graphical user interface of the medical device. The techniques may also involve generating, based on the current state of the graphical user interface, a guidance user interface comprising an ordered sequence of actuations of user input elements to achieve the identified user objective. Additionally, the techniques may involve obtaining updated state information for an updated state of the graphical user interface. The updated state information may be obtained responsive to an actuation of a user input element. Furthermore, the techniques may involve dynamically updating the guidance user interface based on the updated state information.

Abstract: Pumping segments are described herein. In certain embodiments, a peristaltic pumping segment include a tubing segment, a plunger, a downstream occluder, and an upstream check valve. The plunger is movable to selectively expand the pumping volume to draw in fluid flow and contract the pumping volume to administer the fluid flow. The occluder is movable to selectively engage against the downstream portion to prevent fluid flow from the downstream portion during expansion of the pumping volume and to permit fluid flow from the pumping volume through the downstream portion during contraction of the pumping volume. The check valve outlet is in fluid communication with the pumping volume, and the valve element is configured to permit fluid flow from the valve inlet to the pumping volume during expansion of the pumping volume and to prevent fluid flow from the pumping volume to the valve inlet during contraction of the pumping volume.

Abstract: A drug delivery device includes a blunt cannula and a reservoir. The blunt cannula has a cylindrical wall that defines an axial passage between a first end and a second end of the blunt cannula. The wall has at least a first tapered region at the first end to define an opening in fluid communication with the axial passage and adapted at the first end to resist interruption of fluid flow through the axial passage and out of the first end of the blunt cannula. The reservoir is connected to the second end of the blunt cannula.

Abstract: Fill stations and base stations are provided for personal pump systems. The fill stations may be opened and closed to accept a reservoir and to allow fluid to be introduced into the reservoir for use with personal pump systems. The fill stations may hold the reservoir at a tilt relative to an underlying surface and may discourage overfilling of the reservoir. The filling stations may also include viewing windows having fluid lines marked thereon for indicating volume of fluid within the reservoir.

Abstract: An implantable medical device (IMD) includes a drug reservoir located within a reservoir chamber of the IMD that includes a first side and a second side directly opposite the first side defining a reservoir volume there between. The IMD further includes and a volume sensor system including an ultrasound transmitter within the reservoir chamber and positioned to transmit an ultrasound signal toward the second side at an angle relative to the second side and a plurality of ultrasound sensors adjacent to at least one of the first side or second side of the drug reservoir with each sensor positioned to selectively receive the signal from the transmitter at different reservoir volume levels to indicate a current volume capacity of the drug reservoir.