Abstract: The immunoconjugate molecules contain an interleukin-2 (IL-2) polypeptide and a masking moiety capable of inhibiting and activating the IL-2 activity under suitable conditions. Methods for producing the immunoconjugate molecules. The therapeutic uses of the immunoconjugate molecules due to their modulating effects on the immune system for treating diseases such as cancer and other chronic infectious diseases.

Abstract: The present invention provides compositions and methods of use thereof in the treatment of cancer and abnormal immune suppression diseases with antibodies an antigen binding fragments thereof which bind collagen and antibody drug conjugates (ADC). In some embodiments, in the methods provided herein the ADCs target non-cell surface targets associated with tumors.

Abstract: The present disclosure is directed to shear-thinning and stabilizing hydrogels, especially for use in drug delivery, therapy, and 3D printing. Embodiments provide an injectable hydrogel, including: a water-soluble polymer including a first functional group; a host molecule including a second functional group, wherein the second functional group is characterized as complementary to the first functional group; and a guest-terminated star polymer, wherein the guest-terminated star polymer comprises a core unit, a plurality of arms extending from the core unit, and a guest molecule disposed at a terminal end of each of the plurality of arms, and wherein the host molecule and the guest-terminated star polymer are linked by one or more bonds that break under mechanical stress and reform after removal of the mechanical stress.

Abstract: Provided herein are double strand DNA molecules comprising inverted repeats, expression cassette and one or more restriction sites for nicking endonucleases, the methods of use thereof, and the methods of making therefor.

Abstract: According to the present disclosure, the relation between the MeCP2 expression level and depression in D2R neurons of the ventral striatum was first found, and it was confirmed that MeCP2 in D2R neurons of the ventral striatum was significantly decreased due to depressive symptoms, and depressive symptoms were improved when MeCP2 expression in the neurons was up-regulated. Accordingly, the expression level of MeCP2 in D2R neurons of the ventral striatum is provided as a biomarker for diagnosing depression and the up-regulation of the MeCP2 expression is provided as a treatment strategy for depression, and thus, it is expected to be useful as a development platform for drugs for preventing or treating depression in the future.

Abstract: The present disclosure relates to a method (100, 200) for gene editing of a cell or tissue. The method (100,200) includes introducing a gene editing agent into the cell or tissue using a gene delivery vector. The method (100,200) also includes modifying the gene delivery vector with a targeting agent to direct the gene editing agent to the desired cell or tissue. The method (100,200) also includes attuning the gene delivery agent to modify or replace the mutated gene. The method (100,200) also includes introducing other genetic modifications through the genetic agent. The method (100,200) also includes modifying the gene delivery vector with agents to enhance the stability or activity of the gene editing agent.

Abstract: Gene therapy methods, vectors and cargo described herein can reduce or prevent C3b amplification and/or MAC formation within the neural retina, retinal pigmented epithelium (RPE), choroid, choriocapillaris (CC), Bruch's membrane and other ocular cells and tissues to re-establish appropriate control of the complement system. Gene therapy methods disclosed will benefit patients with complement related diseases such as AMD.

Abstract: Provided are recombinant adeno-associated virus (rAAV) vectors comprising a transgene to express galactose-1-phosphate uridylyl transferase (GALT); virions comprising said vectors (rAAV virions); methods of their production; methods of their use, including methods for treating galactosemia, GALT-deficiency, symptoms therefrom; and kits.

Abstract: Provided are methods of treating or ameliorating the symptoms of dystrophinopathies, such as Duchenne muscular dystrophy and Becker muscular dystrophy by administration of therapeutically effective doses of recombinant adeno-associated viruses (rAAV) containing a transgene encoding a microdystrophin in combination with a second therapeutic which is effective to treat or ameliorate the symptoms of the dystrophinopathy.

Abstract: Compositions and methods are provided for the assessment and treatment of age-related conditions and diseases. Also provided are methods for identifying compounds that can potentially regulate the aging process.

Abstract: The present disclosure provides codon optimized nucleotide sequences encoding human REP1, vectors, and host cells comprising codon optimized REP1 sequences, and methods of treating retinal disorders such as choroideremia comprising administering to the subject a codon optimized sequence encoding human REP1.

Abstract: Compounds, systems, and methods are provided for the design and assembly of a non-invasive, analyte sensing dressing. The dressing can be therapeutic. The dressing includes a sensor and a matrix. The sensor is capable of detecting analytes such as molecular oxygen, carbon dioxide, nitric oxides, dissolved analytes in plasma, and hydrogen ions. The matrix is at least partially permeable to the analyte. The device emits a detectable signal when the sensor is excited in the presence of the analyte. In one version of the dressing, the sensor includes a meso-unsubstituted metallated porphyrin that is sensitive towards oxygen. The metallated porphyrin can be excited when illuminated at a first wavelength, followed by emission of phosphorescence at a second wavelength whose intensity can be used as an indicator for oxygen concentration.

Abstract: Methods for early diagnosis of cervical intraepithelial neoplasia in low-income settings are disclosed. This invention primarily addresses inaccurate screening and diagnosis by developing, standardizing, and optimizing an innovative, highly-effective (high specificity, high sensitivity), and low-cost Fluorescein Sodium (FNa) staining method to replace the current burdensome (requires multiple visits), inherently inaccurate (low specificity, high sensitivity) Acetic Acid (AA) staining method.

Abstract: The present invention describes a method for synthesizing a near-infrared probe GGa-ICG that specifically binds to PSCA. The method involves isolating and identifying a nucleic acid aptamer from a prostate cancer cell line that exhibits specific binding to PSCA, and conjugating the aptamer with a near-infrared fluorescent dye to obtain the PSCA-specific binding near-infrared probe GGa-ICG.

Abstract: The present invention relates to a complex of formula (II) constituted of at least 90% of a diastereoisomeric excess comprising a mixture of isomers II-RRR and II-SSS of formulae: The present invention also relates to a process for preparing and purifying said complex of formula (II), and also to a composition comprising said complex.

Abstract: The present invention relates to a method of removal of metal ion impurities, such as calcium, from lanthanide metal complexes of macrocyclic chelators. The method uses a scavenger resin to remove metal ions, displaced from chelator, by an excess of lanthanide ions. Also provided is a method of preparation of MRI contrast agents, from the purified lanthanide metal complex, by the addition of a defined excess chelator.

Abstract: The present disclosure is generally directed to quinolinyl and pyridinyl containing compounds targeting on alpha-synuclein for neurological diseases. These compounds, particularly radiolabeled versions of these compounds, can be particularly useful in PET scans targeting diseases such as Parkinson's disease (PD), Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA).

Abstract: Compounds derived from celecoxib, valdecoxib, and indomethacin, and methods of use thereof, are disclosed. The compounds are useful for, inter alia, identifying and localizing the site of pathology and/or inflammation responsible for the sensation of pain in a patient; for identifying the sites of primary, secondary, benign, or malignant tumors; and for diagnosing infection or confirming or ruling out suspected infection. The compounds contain a radioactive agent which permits imaging. The compounds concentrate at sites of increased cyclooxygenase expression, such as areas of increased COX-2 expression, thus revealing the sites of increased prostaglandin production, which is correlated with pain and inflammation, and correlated with tumor presence and/or location. Identifying areas of increased COX expressing can also aid in screening for infections, assessing efficacy of diagnosis and treatment of rheumatoid arthritis, and assessing the need for treatment with opioid drugs.

Abstract: The present disclosure provides, in part, methods for site-specific labeling of proteins/peptides with radiohalogens and compositions resulting from said methods.

Abstract: An adapter couples an ultraviolet (UV) disinfecting device to a container suitable for holding liquid. The adapter may be a lid adapter that also functions as a lid for the container. The adapter includes a body and a coupler. The body couples to the UV disinfecting device, and the coupler couples to the container. In this way, the UV disinfecting device is in communication with the interior of the container.

Abstract: A self-sanitizing surface structure configured to selectively refract light, a method of fabricating a self-sanitizing surface configured to selectively refract light, and a method of decontaminating a surface using selectively refracted light. A waveguide including a support layer below a propagating layer is positioned over a substrate as a self-sanitizing layer. In the absence of a contaminant or residue on the waveguide, UV light injected into the propagating layer is constrained within the propagating layer due to total internal reflection. When a residue is present on the self-sanitizing surface structure, light may be selectively refracted at or near the interface with the residue along the side of the waveguide to destroy the residue. The self-sanitizing surface structure may be configured to refract a suitable amount of UV light in response to a particular type of residue or application.

Abstract: A disinfection station for disinfection of a storage container in an automated storage and retrieval system includes a frame and a disinfection system. The frame includes a support, by which the storage container is supported in a disinfection position during disinfection, and an opening through which the storage container is transported between a storage position in the automated storage and retrieval system and the disinfection position. The disinfection system is for disinfecting the storage container in the disinfection position. The disinfection system includes a disinfection fluid applicator, a disinfection fluid container, and a pump controlled to pump the disinfection fluid from the container to the applicator. The opening is a top opening. The storage container is lowered through the top opening to the support before disinfection. The disinfection station includes a splash cover for protecting the surroundings from disinfection fluid.

Abstract: An aerosol-surface interface sanitization system comprising a non-toxic, non-corrosive and biocompatible sanitization formulation, and a nebulizer selected from jet-nebulizer, ultrasonic nebulizer or spray gun. This system is designed for interior environment application, and is applicable for both airborne and surface disinfection. The sanitization formulation is formed by membrane emulsification technique to optimize nebulization efficiency through adjustment in viscosity, droplet size, dispersion area and settlement rate, while having a high antiviral, antifungal and antibacterial activity.

Abstract: Systems and techniques for reprocessing a medical device equipped with an electromagnetic tag can include opening an access door of a reprocessing machine and passing the medical device through an entry-opening towards an inside of a washing chamber of the reprocessing machine. The systems and techniques can also involve energizing an electromagnetic tag carried by the medical device with an energizing power source of the reprocessing machine. As the medical device is passing through the entry-opening (EO) towards the inside of the washing chamber and in response to the energizing, the system can receive an identification electromagnetic signal transferred by the energized electromagnetic tag with a receiver the reprocessing machine. Information associated with the identification electromagnetic signal can be used to select and/or control washing parameters of the reprocessing machine.

Abstract: A method of inactivating pathogens in an environment, the method including moving a base of a mobile robot carrying a pathogen detector on a base surface; moving the pathogen detector by means of a manipulator; obtaining pathogen data by means of the pathogen detector, the pathogen data being indicative of a presence of pathogens in one or more detection regions of the environment; moving a base of a mobile robot carrying an inactivation device on the base surface based on the pathogen data; moving the inactivation device based on the pathogen data by means of the manipulator carrying the inactivation device; and controlling the inactivation device to inactivate the pathogens.

Abstract: A method comprising of a modular and configurable sanitization system that includes one or more panels and a processing module. The processing module is operable to obtain configuration data pertaining to one or more of: the one or more panels, one or more configurable sanitizing mechanisms, and one or more sanitization subjects, determine one or more sanitization protocols based on the configuration data, generate one or more sanitizing mechanism configuration instructions to configure the one or more configurable sanitizing mechanisms based on the one or more sanitization protocols and in accordance with the one or more sanitization subjects, generate one or more panel configuration instructions to configure the one or more panels based on the one or more sanitization protocols and in accordance with the one or more sanitization subjects, and configure the one or more configurable sanitizing mechanisms and the one or more panels.

Abstract: A cassette that includes at least one tray defined by a plurality of walls extending from a panel to receive at least one dental instrument in a reception space defined by the walls, and a locking mechanism, or at least one lockable lock bar, or one part of a coupling mechanism, located in the reception space.

Abstract: Various embodiments are directed to a coronavirus air sanitization/isolation system with anti-virus curtain. The system may include a group of anti-virus strips with attached separation magnets coupled to an air inlet housing mounted above (e.g., in an attic ceiling) in an enclosed space. The anti-virus strips may be coated with a saline and soap solution that attracts airborne droplets contaminated with the coronavirus and dissolves a fatty layer of coronavirus cell membranes to prevent cell replication of the coronavirus, thereby destroying the coronavirus. The air inlet housing may include exhaust ventilation fans, salt filters, a wick saturated with the saline and soap solution, an electro-static air filter, and a distribution air duct. The fans may be utilized to circulate an airstream containing the coronavirus through the anti-virus strips, the filters, the saturated wick, and the distribution air duct to remove the coronavirus while protecting occupants with uncontaminated air.

Abstract: A volatile composition dispenser includes a cartridge comprising a reservoir of at least one liquid volatile composition and a breathable membrane for enclosing the reservoir and evaporating the at least one liquid volatile composition into the atmosphere upon activation of the volatile composition dispenser. The cartridge is disposed in a housing having opposing first and second walls, while the second wall has a plurality of evaporation vents and is characterized by a Total Vent Area (T). A scent intensity controller is attached to said housing for adjustably covering at least some or portions of said plurality of evaporation vents on the second wall. The volatile composition dispenser is characterized by an Un-Adjustable Vent Area (U) that is no more than 15% of the Total Vent Area (T), which helps to deliver improved scent intensity control.

Abstract: Various embodiments of diffusing devices are described. The diffusing device can include a cover or retaining ring that attaches to the diffusing device to hold a scent cartridge in place. The scent cartridge can include a top plate suspended above the cartridge and preferably supported solely by the cartridge such that air flowing from the scent cartridge is circumferentially dispersed from the scent cartridge.

Abstract: A dispensing system for dispensing a fluid into the atmosphere which includes a container for containing a liquid solution, a rigid support and a capillary fabric, wherein a first section of the support is positioned inside the container through an opening of the container and a second section of the support is positioned outside the opening of the of container, wherein the support is at least partially U-shaped or L-shaped by means of the second section of the support. The capillary fabric is attached around the first section and second section of the support, such that the capillary fabric can draw up the liquid solution from the container by capillary attraction to dispense a gaseous fluid into the atmosphere outside the container by means of evaporation of the liquid solution.

Abstract: An isolation section assembly includes a section housing defining an interior space. The section housing includes a door with access to the interior space. The isolation section assembly includes an enclosure abutting the door. The airlock enclosure defines an interior airlock space. The interior airlock space is configured and adapted to be at a negative pressure relative to a cabin area. An air recirculation system in fluid communication with at least one of the interior space of the section housing or the interior airlock space.

Abstract: An air purification system is provided. The air purification system utilizes a multi-pronged approach to both filter air as well as irradiate it with ultraviolet light. Optionally, a humidifier and/or dehumidifier may be used to further treat the outlet air. The system may be positioned fixedly in building air ducts, or may be used in mobile applications to treat and purify air in a room or other space.

Abstract: The present disclosure relates to the technical field of an air disinfection machine, and discloses a fixing structure of an ultraviolet lamp tube of an air disinfection machine, which comprises a bracket and a lamp post assembly provided on the bracket, wherein a catalytic assembly is provided on the bracket and covers the lamp post assembly, the bracket is provided with a first mounting table, the lamp post assembly penetrates through the first mounting table, the catalytic assembly comprises a protective cover which covers the lamp post assembly, the protective cover is further provided with a photocatalyst coating, a mounting seat protective cover is provided on a mounting seat, and the mounting seat is provided on the first mounting table through threaded connection.

Abstract: Antimicrobial material which is a composite of a matrix component comprising a flexible hydrophilic polymer foam or fiber matrix comprising two matrix faces providing a release face and a reverse face or two release faces, and therebetween a structural matrix framework defining a network of cells having a cell network surface and therein a network of pores or cell openings, and a powder charge component comprising antimicrobial additive or wound care additive, wherein said powder charge is comprised at one said release face or both said faces and/or within said cell network wherein said composite is an assembly of pre-formed matrix component and powder charge component; and asymmetric material which is asymmetric having regard to distribution of said powder charge therein; and material wherein said power charge comprises flowing agent and/or bulking agent and/or binder and wherein said additive and/or flowing agent is co-located with said bulking agent and/or said binder; devices comprising said composite, me

Abstract: A composition includes a ferrocene-containing polyelectrolyte complex. Ferrocene in the polyelectrolyte complex may be bound to the polycation or the polyanion prior to combining the polycation and the polyanion. The polycation may be chitosan. The polyanion may be alginate. A wound dressing utilizes the composition.

Abstract: A liquid polymeric composition including: (a) from about 2 to about 20 weight percent of a polymer; (b) from about 5 to about 40 weight percent of a radiopaque molecule with a molecular weight below 2000 g/mol; and (c) from about 40 to about 93 weight percent of a non-physiological solvent or solvent system; wherein (i) the sum of the weight percent of all components in the composition is 100, (ii) the polymer and the radiopaque molecule are not covalently bound and are both dissolved in the non-physiological solvent or solvent system, and (iii) the polymer is soluble in the non-physiological solution and insoluble in a physiological solution at room temperature, and (iv) the liquid polymeric composition is capable of forming, upon contact with physiological conditions, a radiopaque precipitate which maintains at least 50% of its radiopacity during at least 30 minutes and loses at least 50% of its radiopacity in less than 6 months.

Abstract: The present application relates to a bone graft material composed of porous whitlockite including nanopores with a size of 100 nm to 1,000 nm, micropores with a size of 1 ?m to 100 ?m, and macropores with a size of 100 ?m to 1,000 ?m. Having pores with various sizes, the bone graft material exhibits the effect of being brought into wide contact with in vivo components and maintaining an appropriate mechanical strength.

Abstract: A porous material suitable for implant is disclosed comprising a large plurality of substantially spherical intercalated hollows in a polymer. The hollows are formed by combining the polymer with a fugitive material under heat and pressure and subsequently removing the fugitive material to reveal the hollows. Intercalation can be increased by subjecting the fugitive material to a coalescing compacting process prior to combining the fugitive material with the polymer. The porous material can be combined with a solid material such as a solid polymer to fabricate complex implantable materials with a variety of features.

Abstract: Methods for mixing highly concentrated hydrogels are provided herein. The methods can be performed aseptically. Hydrogels created by this process may include many types of polymers, which may include glycosaminoglycans such as hyaluronic acid. The hydrogels formed by the methods described herein may further include and/or incorporate other molecules having biological activity.

Abstract: Methods and compositions employing hybrid hydrogels formed of high molecular weight hyaluronic acid and a plurality of self-assembled peptides in inducing bone regeneration are provided.

Abstract: The present invention relates to a mineralized collagen material, a preparation method therefor, and an application thereof. The preparation method comprises: dissolving type I collagen, a calcium source, and acid in a first solvent to obtain a first solution; dissolving alkali and a phosphorus source in a second solvent to obtain a second solution; under the condition that a temperature is less than or equal to 45° C., adding the second solution into the first solution and mixing to obtain a third solution; and placing the third solution in a deionized water solvent or an ethanol solvent for soaking, and removing impurities to obtain a mineralized collagen gel.

Abstract: The present invention is directed to a nerve regeneration conduit including a resorbable tube having a matrix therein. The matrix is characterized by substantially parallel, axially aligned pores extending the length of the matrix. The matrix is formed by the axial freezing of a slurry having little or no significant radial thermal gradient during the freezing process. The matrix is used to bridge the gap between the severed ends of a nerve and provide a scaffold for nerve regeneration.

Abstract: In some embodiments, the present disclosure pertains to an injectable shear-thinning composition that comprises (a) one or more types of polymers, (b) one or more types of microparticles and (c) water. In some embodiments, the present disclosure pertains to a kit that comprises (a) one or more containers that contain an injectable shear-thinning composition that comprises one or more types of polymers, one or more types of microparticles and water and (b) a delivery device. In some embodiments, the present disclosure pertains to a medical procedure comprising administering to a subject an injectable shear-thinning composition that comprises one or more types of polymers, one or more types of microparticles and water.

Abstract: This disclosure describes, inter alia, materials, devices, kits and methods that may be used to treat chronic sinusitis. More specifically, a drug-eluting scaffold is implanted in the middle meatus to treat chronic sinusitis for weeks to months.

Abstract: Provided is a cell sheet suitable for cartilage repair. The present invention provides a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the cell sheet is negative for immunostaining using an antibody against type II collagen. The present invention also provides a method for producing a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the method includes culturing cells derived from a cartilage tissue on a surface of a membrane, where a temperature-responsive polymer is immobilized on the surface, to give the cell sheet. The culturing is stopped before the cell sheet becomes positive for immunostaining using an antibody against type II collagen.

Abstract: Disclosed are a model training method, a visual perception method, an electronic device and a storage medium. The model training method is applicable to a spiking recurrent model in a retinal prosthesis and includes: determining labels respectively corresponding to ganglion cells based on a preset ganglion cell response dataset; obtaining multiple spike signals as training samples; inputting the spike signals into the spiking recurrent model, obtaining spike responses of the ganglion cells predicted by the spiking recurrent model, and computing a loss value based on the spike responses of the ganglion cells, the labels and a preset Poisson loss function; and updating a weight for each layer in the spiking recurrent model based on the loss value and a preset time backpropagation function recursively until the spiking recurrent model converges, thereby scientifically and quickly training the spiking recurrent model for predicting the responses of retinal ganglion cells.

Abstract: In some embodiments, the present disclosure pertains to an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers. In some embodiments, the present disclosure pertains to kits that comprise a syringe preloaded with an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers. In some embodiments, the present disclosure pertains to methods of treatment comprising injecting into a subject an injectable suspension that contains radiopaque crosslinked hydrogel particles in a carrier fluid that comprises one or more types of linear hydrophilic polymers.

Abstract: A medical device having resistance to Candida albicans yeast and antimicrobial activity includes a medical device surface having a copolymer coating of antifungal moieties and ionic binding moieties. The copolymer coating is obtained by copolymerizing antifungal monomers selected from tricyclodecane dimethanol diacrylate, 4-tert-butylcyclohexyl acrylate, neopentyl glycol diacrylate, trimethylcyclohexyl methacrylate, isobornyl acrylate, and mixtures thereof and ionic binding monomers selected from acrylic acid, methyl acrylate, and mixtures thereof. The coating may be loaded with elutable antimicrobial substances ionically bound to the ionic binding moieties. The antimicrobial substances may be cationic, such as, a cationic dye such as ethyl violet chloride, a cationic drug such as chlorhexidine diacetate, cationic peptides such as cecropins, magainins, protegrins, and bactenicins, or ionic silver.

Abstract: The present invention relates to a drug delivery system for medical devices comprising a combination of at least one cellulose compound or derivative thereof and one compound with cyclopenta[a]phenanthrene structure or a structure derived therefrom or derivative thereof alone or in combination with other substances and a method for the preparation thereof. Said drug delivery system further comprises at least one active ingredient intended to treat a disease whereas said drug delivery system has favorable drug delivery properties. The present invention has applications in drug formulations and in medical devices such as balloons. stents. grafts. patches. catheters and implants of all kinds.