Abstract: An elongated composite for an implant comprising: one or more composite elements includes a core region including a plurality of fibrous bundles, (which are preferably braided, woven, bound, interlaced and/or interlocked by bias fiber elements) wherein the core region of the composite elements includes a polymerizable material or polymeric material which fills gaps between the fibrous bundles, (preferably wherein the each of the one or more composite elements has a second region including a polymeric covering formed of a polymerizable material or a polymeric material); and a covering over the one or more composite elements, preferably wherein the covering provides one or more functional features to the composite.

Abstract: A breast pump wearable inside a bra, including a breast shield adapted to at least in part receive a breast of a lactating user, an aggregate for generating suction for expressing milk from the breast, a milk container providing a reservoir for the expressed milk, an accelerometer and a controller operatively connected with the accelerometer and provided for controlling the aggregate. To determine the volume of expressed milk within the milk container with higher accuracy, a sensor is assigned to the reservoir for determining the milk level within the reservoir (46), wherein the controller is operatively connected with the sensor and wherein the controller is adapted to output a signal indicative of the risk of milk spillage from the reservoir on the basis of the signals received from the accelerometer and from the sensor.

Abstract: A breast pump wearable inside a bra, including a breast shield adapted to at least in part receive a breast of a lactating user, an aggregate for generating suction for expressing milk from the breast, a milk container providing a reservoir for the expressed milk, an accelerometer, and a controller operatively connected with the accelerometer and provided for controlling the aggregate. To determine the volume of expressed milk within the milk container with higher accuracy, a sensor is assigned to the reservoir for determining the milk level within the reservoir (46), wherein the controller is operatively connected with the sensor and where-in the controller is adapted to output a signal indicative of the risk of milk spillage from the reservoir on the basis of the signals received form the accelerometer and from the sensor.

Abstract: The present disclosure provides a milk distribution system, components thereof, and methods of use thereof.

Abstract: Described is a gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet. The gas exchanger also includes: a hollow fiber bundle disposed within the housing between the core and the outer wall; and a gas inlet compartment for receiving an oxygen supply and directing the oxygen supply to first ends of the hollow fiber bundle, wherein the gas inlet compartment includes at least one restriction element configured to allow the oxygen supply to reach only a portion of the hollow fiber bundle.

Abstract: A dialysis system includes include a home dialysis machine and a home gateway device in communication with a cloud-based application via a connected health system. The gateway device has voice recognition capabilities. A user can provide spoken information to the gateway device, and the gateway device can cause one or more actions to be performed. The gateway device may cause a dialysis function to be performed by the dialysis machine, or data to be input into the dialysis machine. The gateway device can also communicate with one or more other systems (e.g., remote systems) via the cloud-based application. In some examples, the cloud-based application can communicate with an order management system to allow the user to order medical supplies (e.g., for use with the dialysis machine) via the gateway device. The gateway device can provide two-way conversational capability (e.g., back and forth communication) between the user and the gateway device.

Abstract: A circuit for measuring the conductivity of a medical fluid, the circuit comprising: a data collecting cell through which a medical fluid is configured to flow; an input voltage source that provides an input voltage to the data collecting cell; a voltage measurement unit configured to measure the input voltage and an output voltage of the data collecting cell; and a switch in communication with the voltage measurement unit, the switch configured to switch between a first state in which the voltage measurement unit is configured to measure the input voltage and a second state in which the voltage measurement unit is configured to measure the output voltage of the data collecting cell.

Abstract: A method for collection blood component using a medical system includes receiving, by the medical system, data associated with an individual subject, the data associated with the individual subject including a subject's initial hematocrit; identifying, by the medical system, a subject-specific pure component amount to be collected by the medical system, the subject-specific pure component amount to be collected by the medical system determined using the subject hematocrit, a total blood volume for the subject, and a targeted change in hematocrit; and performing, using the medical system, a component donation process to collect the identified subject-specific pure component amount to be collected.

Abstract: A bedside cell processing system including an apheresis system configured to collect from a patient a blood component comprising target cells, a cell processing system configured to receive the target cells from the apheresis system and to process the target cells, and a reinfusion system configured to receive the processed target cells and to return the processed cells to the patient. A method of operating a bedside cell processing system for a patient also is provided, including operating the apheresis system to collect from the patient via a collection flow path a blood component comprising target cells, operating a cell processing system to receive the target cells via a collected target cells flow path and to process the target cells, operating the reinfusion system to receive the processed target cells via a processed target cells flow path and to return the processed target cells to the patient.

Abstract: A system includes an anti-vacuum surge (AVS) mechanism and a processor. The AVS mechanism is configured to suppress a vacuum surge during the phacoemulsification procedure. The processor is configured to (i) during the phacoemulsification procedure, receive pressure readings from one or more sensors, (ii) using the pressure readings, estimate an occurrence of a vacuum surge, and (iii) upon estimating the occurrence of the vacuum surge, activate the AVS mechanism in a predefined pulsed manner to suppress the vacuum surge.

Abstract: A system for surgical suction and/or irrigation is provided that can be rendered stiff or flexible. In some embodiments, the system comprises a rod and two flexible and substantially coaligned conduits. A second conduit of the two substantially coaligned conduits can be sealed on a distal end and can have an inner diameter larger than or equal to an outer diameter of the rod. The rod can have a modulus of elasticity of at least 1 mPa. The second conduit can be configured to admit the rod while surgically inserted in a patient and without being removed from the patient. At least a first portion of a first conduit of the two substantially coaligned conduits can be bonded or coextruded to at least a second portion of the second conduit.

Abstract: A system for treating a wound, having a wound treatment device, a fluid input upstream side of the device, a fluid output downstream of the device; an air inlet valve upstream of the fluid output; an actuator to drive the air inlet valve between open and closed positions; a pump downstream of the fluid input; a motor to drive the pump to provide a negative pressure to the device; and a controller in configured to operate the air inlet valve and the pump. The controller is configured to (i) open the air inlet valve and operate the pump to maintain a first vacuum pressure at the wound treatment device and introduce air into the device, and (ii) close the air inlet valve and operate the pump to maintain a second vacuum pressure at the wound treatment device and remove air and fluid from the device.

Abstract: In accordance with some configurations, systems and methods for guided removal from an in vivo subject are provided. In some configurations, a method for removing an object is provided. The method comprising, guiding a flexible tube through a passageway of an in vivo subject, wherein the flexible tube comprises at least a first passageway and a second passageway. Positioning a distal end of the first passageway in proximity to the object. Infusing liquid through the second passageway substantially continuously. Removing the object through the first passageway with at least a portion of the liquid while suction is not being provided.

Abstract: A packaging assembly comprises a case configured to at least partially contain a plurality of injection devices for delivering a medicament; a light sensor configured to detect light incident on the packaging assembly; and a wireless communication module configured to establish a wireless connection with at least one external device conditional on an intensity of light detected by the light sensor exceeding a threshold light intensity.

Abstract: A system for controlled delivery of medical fluids to a patient includes an inlet conduit attached to a source of a medical fluid and an outlet conduit connected to the patient. The inlet and outlet conduits are interconnected by a multiple stage control valve assembly and a pair of syringes. The control valve assembly is alternated between a first state wherein the inlet conduit communicates with a first syringe for transmitting fluid from the source to the first syringe, a second state wherein the first syringe communicates with a second syringe and is isolated from the inlet conduit and the outlet for transmitting fluid from the first syringe to the second syringe, and a third state wherein the second syringe communicates with the outlet and is isolated from the inlet and the first syringe for transmitting fluid from the second syringe to the patient through the outlet.

Abstract: Systems and apparatuses for pressurized fluid system handpieces having pumps and pump cartridge mechanisms. The system may have a console, the pump and pump cartridge, and the handpiece, with the pump and pump cartridge configured to deliver high velocity fluid to the handpiece. The pump may comprise the pump cartridge, at least one actuator and a means for driving the at least one actuator. The means for driving the at least one actuator drive fluid from an inlet into the pump cartridge and forces the fluid out of the pump cartridge through an outlet to the handpiece.

Abstract: The present invention relates to an at least partly implantable system for injecting a substance into a patient's body. The system comprises at least one implantable infusion needle arranged in at least one first housing, the at least one implantable infusion needle having a tip end for injecting a substance into a penetration area of a patient, and at least one drive unit coupled to the at least one implantable infusion needle and arranged for moving the tip end of the at least one infusion needle for varying the penetration site, wherein the at least one drive unit is a drive unit arranged for moving the tip end of the at least one infusion needle using hydraulic force. The system is adapted to use infusion liquid to be injected into the patient's body as hydraulic fluid.

Abstract: A safety quick-refill compact pump for administering drugs is provided. The pump includes a motor-driven electromechanical actuator, a cylindrical container, and a hollow piercing element. The actuator causes bi-directional axial sliding of a rod that carries a pusher adapted to cause axial sliding of a plunger of the container which contains a liquid drug and is equipped, at an end thereof, with a pierceable membrane. The actuator is provided with a first connecting portion of a male-female connecting joint at least partially surrounding the rod. The container is provided with a second connecting portion of the male-female connecting joint and is firmly associated with the actuator and defines a cylindrical chamber axially extending about the sliding axis of the rod. The piercing element is oriented toward the inside of the chamber and defines a duct so that the piercing element is in fluid communication with the inside of the reservoir.

Abstract: A device for protecting a user from a sharp tip of a medical needle includes a central body portion, a medical needle having a sharp tip, a pair of wings in attachment to the central body portion, and a hook-and-loop fastening system disposed on at least one of the wings, and configured to selectively attach the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle. A method of using the device includes withdrawing a sharp tip of a medical needle from a patient, closing a pair of wings with the medical needle positioned between the wings, and fastening the wings together with the medical needle positioned between the wings so as to protect a user from the sharp tip of the medical needle.

Abstract: Apparatus including tubing sets and methods of use are described for deliver a therapeutic medication to a patient, the apparatus comprising a controller and a sensor. The controller is configured to receive data from the sensor, and to start and stop delivery of the therapeutic medication to the patient in response to data received from the sensor. In addition, apparatus, systems and methods are disclosed, which are configured to deliver a therapeutic medication to a patient. The apparatus, system and methods comprise a reservoir, a patient interface, a tubing set, and a fluid pump, and the components are configured to provide a calibrated flow rate based upon specific characteristics of the therapeutic medications passing through and internal lumen of the tubing set.

Abstract: Systems comprising: an analyte sensor for providing an analyte signal representative of an analyte level; a controller in data communication with the analyte sensor and programmed to provide a recommended medication dose based on the analyte level and a medication type, the controller comprising a user interface for inputting the medication type; and a model-based safety mechanism integrated with the controller for evaluating the recommended medication dose. Wherein the model-based safety mechanism overrides the recommended medication dose and provides a safety medication dose when the model-based safety mechanism detects a risk of insulin deprivation.

Abstract: Techniques disclosed herein relate to configurable target glucose values. In some embodiments, the techniques may involve modifying a glucose setpoint from a first target value to a second target value, wherein the second target value is lower than the first target value. The techniques may further involve regulating a glucose level of a patient to the modified glucose setpoint by controlling insulin delivery. The techniques may further involve after a time period has elapsed, reverting the glucose setpoint to the first target value.

Abstract: A multi-chamber device having a barrel with a first chamber and a second chamber, and a plunger assembly with a first plunger rod advanceable with respect to the first chamber and a second plunger rod advanceable with respect to the second chamber. The ends of the first and second plunger rods are independently advanceable to advance different amounts of material from the first and second chamber as the plunger assembly is advanced with respect to the barrel. The multi-chamber device may be part of a multi-chamber system including an injection system. The multi-chamber device and the injection system may include engaging elements facilitating ready coupling and decoupling of the multi-chamber device and the injection system.

Abstract: Mixing systems for producing a mixture to deliver to a treatment site. An illustrative system may comprise a needle hub and a multi-reservoir system including a plunger assembly and a barrel portion. The barrel portion may include a first lumen, a second lumen, and a plurality of channels formed in a wall of the first lumen. A first movable gasket may divide the first lumen into a first reservoir configured to contain a first constituent and a second reservoir configured to contain a second constituent. A second gasket may bound a third reservoir configured to contain a third constituent. Actuating the plunger assembly relative to the barrel portion may first cause the diluent to be injected into the second reservoir to form a precursor and then cause the precursor and the second constituent to be delivered into the needle hub.

Abstract: A novel single use auto-injector for delivering a fixed amount of medicament is described. The auto-injector may include a sealed housing rotatably held in a cover. Once the auto-injector is positioned at the injection location, the user can transition the housing from a locked to an armed position. The user can then compress the sealed housing into the cover, triggering activation mechanisms that initiate the injection. A first activation mechanism engages an interlock to prevent reuse of the auto-injector. A second activation mechanism straightens and extends a curved needle to a set the exposed needle length. A third activation mechanism pierces a sealed reservoir allowing the medicament to be forced through the injection needle. Following the injection, the auto-injector expands and interlocks, retracting the needle into the auto-injector and preventing reuse.

Abstract: Mixing systems for producing a mixture to deliver to a treatment site. An illustrative system may comprise a needle hub and a multi-reservoir system. The multi-reservoir system may comprise a first plunger assembly, a second plunger assembly, and a barrel portion. The first plunger assembly, the second plunger assembly, and the barrel portion may be assembled in a telescoping arrangement. Advancing the first plunger assembly may cause a first constituent to be delivered from a first reservoir of the second plunger assembly into the third reservoir to mix with a third constituent to form a precursor and a second constituent to be delivered from a second reservoir of the second plunger assembly into the fourth reservoir and advancing the first and second plunger assembly collectively causes the precursor and the second constituent to be delivered into the needle hub.

Abstract: Mixing systems for producing a mixture to deliver to a treatment site. An illustrative system may comprise a needle hub, a multi-reservoir system, and a syringe. The multi-reservoir system may comprise a plunger assembly including a first tubular plunger and a second tubular plunger, a barrel portion including a housing defining a first reservoir in fluid communication with a first port and configured to contain a first constituent and a second annular reservoir configured to contain a second constituent and in fluid communication with a second port, and a third plunger. A third constituent may be injected from the syringe into the first reservoir to form a precursor. Actuating the plunger assembly relative to the barrel portion may cause the precursor and the second constituent to be delivered into the needle hub.

Abstract: An expulsion assembly (100) of a medicament delivery device (102) for expelling medicament from a medicament container structure (250), the expulsion assembly comprising a container holder (125) having a container proximal end (212) and a container distal end (214), the container holder being configured to house the medicament container structure, and an axially extending needle cover (123), the needle cover having a needle cover proximal end (202) comprising a tubular shaped needle cover portion (206), and a needle cover distal end (204), wherein the container holder is at least partly enclosed by the needle cover, wherein a portion (121) of the outer surface of the container holder (125) and a portion (129) of the needle cover form an interface section (127) comprising an axially extending groove (220) and a protrusion (222) in which the container holder and the needle cover are arranged in abutment with each other.

Abstract: Mixing systems for producing a mixture to deliver to a treatment site. An illustrative system may comprise a needle hub, a multi-reservoir system, and a syringe. The multi-reservoir system may comprise a plunger assembly including a first plunger and a second plunger, a barrel portion including a housing defining a first reservoir in fluid communication with a first port and configured to contain a first constituent and a second reservoir configured to contain a second constituent and in fluid communication with a second port, and a cap including a port and a lumen extending therethrough. A third constituent may be injected from the syringe into the first reservoir via the port of the cap to form a precursor. Actuating the plunger assembly relative to the barrel portion may cause the precursor and the second constituent to be delivered into the needle hub.

Abstract: The present disclosure relates to an injection head of a needleless syringe, needleless syringe body, and needleless syringe. The injection head includes a medicine barrel and a piston rod. The medicine barrel opens at a rear end and has an injection micropore at a front end. A piston of a piston rod is movable within a chamber in an front-rear direction, the piston and a sidewall and a front wall of the medicine barrel jointly define a medicine liquid receiving chamber. The piston rod is provided therein with a medicine liquid channel. The injection head and the vial can be mounted together on the needleless syringe body, the medicine liquid can flow via the medicine liquid channel into the medicine liquid chamber, and the piston rod can eject medicine liquid within the medicine liquid receiving chamber outside via the injection micropore.

Abstract: The present disclosure provides a plunger rod for a medicament delivery device. The plunger rod includes a base at the proximal end of the plunger rod, a first arm extending from the base, and a second arm extending from the base. Each of the first arm and the second arm is flexible and configured to transform from a first rolled-up configuration to a second extended configuration.

Abstract: An apparatus for infusing medical liquid may include: a base body, a needle assembly mounted on the base body, a reservoir unit fluidly connected to the needle assembly and having a plunger therein, a driving unit including a rod, which is connected to the plunger and moves along the reservoir unit, and a driving wheel, which has a protrusion and transmits driving force to the rod, and a connection member disposed between the rod and the driving wheel and having a guide groove for guiding the movement of the protrusion.

Abstract: A gasket is formed to be in liquid-tight and slidable contact with the inside of a plastic outer cylinder of a syringe, the gasket includes: a gasket body including an elastic body; and a coating layer provided at least at a part in contact with the syringe, the coating layer is an elastic cured coating layer containing a silicone-based resin as a main component and containing a carbodiimide compound together with a silane coupling agent, and the silicone-based resin includes a condensate of a reactive silicone having a silanol group at both terminals and has a siloxane bond derived from the silanol group.

Abstract: The present invention provides a dose delivery device (1, 100, 200, 300, 400) comprising: a variable volume reservoir (10, 110, 210, 310, 410) holding a pharmaceutical suspension and comprising an outlet (12, 112, 212, 312, 412), a dose expelling mechanism adapted for activation to expel a volume of the pharmaceutical suspension through the outlet (12, 112, 5 212, 312, 412), and a dose preparation system comprising a preparation member (30, 130, 230, 330, 430) operable prior to activation of the dose expelling mechanism to enable administration of the volume of the pharmaceutical suspension to a subject, wherein the dose preparation system further comprises an agitation member (40, 140, 240, 340, 440) capable of agitating relative motion with respect to the variable volume reservoir (10, 110, 210, 310, 10 410), the agitating relative motion causing a re-suspending agitation of the pharmaceutical suspension, and wherein the agitation member (40, 140, 240, 340, 440) is operatively coupled with the preparation m

Abstract: A data collection device including an attachment assembly for attaching the data collection device to a dose setting dial of a medicament administration device, a light source configured to illuminate a portion of a surface of an internal component of the medicament administration device including a pattern of relatively reflective and non-reflecting regions formed on the surface of the internal component, and an optical sensor configured to receive light reflected by at least the relatively reflective regions.

Abstract: A data collection device comprises an attachment assembly for attaching the data collection device to a dose setting dial of a medicament administration device and a sensor configured to detected an identifier provided on a surface of an internal component of the medicament administration device, the sensor comprising an ultrasound sensor configured to detect a geometric identifier formed on the surface of the internal component of the medicament administration device. A system comprises the data collection device and the medicament administration device.

Abstract: Provided herein is a plunger device for a drug delivery device, including a plunger rod having a proximal end and a distal end configured to be attached to a stopper, a first switch and a second switch arranged at the proximal end, at least one processor in communication with the first switch and the second switch, and at least one communication interface, wherein the at least one processor is programmed or configured to receive a first signal when the first switch is activated, generate first time data, transmit, with the at least one communication interface, the first timestamp, receive a second signal when the second switch is activated, generate a second time data, and transmit, with the at least one communication interface, the second time data.

Abstract: The present disclosure discloses an atomizing nozzle and a nasal drug delivery device. The atomizing nozzle includes a spray hood which includes a conical hood body and a connecting cylinder provided inside the hood body and connected to the inner top of the hood body, the wall of the connecting cylinder is provided with a bayonet structure or a claw structure for non-detachable snap fit with the corresponding claw structure or the bayonet structure on the outer side of the syringe extending into the connecting cylinder, a columnar end extends from the external tip of the hood body for extending into the internal nasal cavity, the connecting cylinder, the columnar end and a portion of the hood body therebetween jointly form a communicating channel, the front end of the columnar end is provided with a spray hole, and a fluid-guiding cylinder.

Abstract: An insufflator (1) monitors the rate of insufflating of the peritoneal cavity (3) in the body (5) of a human subject by monitoring the increase in cavity pressure per unit time in order to avoid bradycardia (slow heart rate). A plurality of reference values of the maximum increases in cavity pressure per unit time is stored in a look-up table (23) for different body cavities for male and female subjects of different age ranges and different body mass index ranges. The particulars of the cavity (the peritoneal cavity 3) the sex, age and body mass index of the subject are inputted into the insufflator (1) through a touchscreen (30), and a microprocessor (20) determines the appropriate maximum increase in the cavity pressure per unit time from the look-up table (23).

Abstract: An insufflating system (201) comprises an insufflator (204) and an endoscope (205). The insufflator (204) comprises a flow control valve (217) for supplying insufflating gas to a cavity of a subject, and an isolating valve (222) for applying a vacuum to the cavity, both of which are connected to an instrument channel (208) of the endoscope (205) through a tube set (230). A pressure sensor (224) monitors cavity pressure through the instrument channel (208). The insufflator (201) is operable in a first operating mode in which a microprocessor (221) operates the flow control valve (217) to maintain the cavity pressure at a set pressure, and on the cavity pressure exceeding a predefined upper pressure, the microprocessor (221) operates the isolating valve (222) for applying vacuum to the cavity, and for further second time periods until the cavity pressure returns to the set pressure.

Abstract: Provided herein are devices, systems, and methods for providing respiratory therapy to a patient using a nasal cannula comprising a cannula body, first and second inlet tubes, and a nasal prong for the delivery of a flow of breathing gas to the patient. Configured with the cannula is a nebulizer having an aerosol generator positioned to emit aerosolized medicament along a longitudinal axis of the nasal prong. A flow director is configured to direct the flow of breathing gas into the nasal prong such that the breathing gas flows along the longitudinal axis, such that the flow of aerosolized medicament is contained within the flow of breathing gas as it moves along the longitudinal axis of the nasal prong for delivery to the patient.

Abstract: A system and method is disclosed for performing diagnostics on patient devices (720). The patient devices (720) may include respiratory therapy devices that operate in accordance with instruction sets, such as software or firmware. A server (710) may maintain a database of diagnostic data (718) indicating faults in one or more of a plurality of patient devices (720). The server (710) may transmit this diagnostic data (718) to one or more computing devices (760), including identification of faults that have occurred. The server (710) may also transmit service data to the plurality of patient devices (720) in order to address the identified faults.

Abstract: A ventilator apparatus comprising a ventilator with at least one actuator, at least one computing system connected to the at least one actuator, at least one transducer to provide input signals from a patient, a closed loop controller, connected to the computing system, configured to provide output data representing a delivered respiratory parameter of the ventilator, including at least one of: a respiratory pressure, a respiratory volume, and a respiratory flow, based on the computed respiration frequency, the estimated inspiratory time, the estimated expiratory time and the computed tidal volume; and the first duration ratio factor is computed with the computing system by: D1=(I:E)/((1+I:E)); wherein I:E is the inspiration-to-expiration ratio and said first duration ratio factor (D1) is used for computing of the respiration frequency, or the first duration ratio factor is set to a value between 0.5 and 0.2 and is used for computing of the respiration frequency.

Abstract: A breathing assistance device with continuous positive airway pressure for the treatment of sleep-related breathing disorders includes an air inlet duct conveying an incoming air flow to a compressor. There is a compressed air flow at the outlet of the compressor connected to a pressurized air outlet duct to a mask applied to the respiratory tract of a patient. The air inlet duct opens into a compartment that is upstream-looking in the direction in which the air flows—from the inlet of the compressor, and has, at that location, a guiding device for the flow of air first toward a bottom wall of the compartment oriented substantially perpendicular to the direction of suction of the air in the compressor. The bottom wall is at least partially covered with a structure with rigid and non-deformable honeycomb patterns.

Abstract: A ventilator comprising an inlet, an outlet and a blower, wherein the ventilator forms, between the inlet and the outlet, a respiratory gas path which is routed through the blower. The ventilator, for the routing of the respiratory gas path, further comprises a chamber, a first channel leading into the chamber, and a second channel leading into the chamber. A first acoustic impedance of the first channel and a second acoustic impedance of the second channel deviate from a third acoustic impedance of the chamber such that a sound generated by the blower is attenuated.

Abstract: A breathing assistance device with improved pressure characteristics provides a high level of CPAP per unit of supplementary respirable gas consumed while maintaining low CPAP fluctuations throughout the breath cycle utilizing a frustrum-shaped air channel that has no unblocked openings to accelerate air flow. In some embodiments, a manometer is provided for monitoring pressure and/or a pressure relief valve is provided as a safety measure against overpressure delivered to a patient. In some embodiments, the device is disposable for one-time or single patient use.

Abstract: Apparatus and methods detect sleep disordering events. The apparatus may be configured to access one or more physiological signals generated by one or more sensors. The apparatus may be configured to detect, from the one or more physiological signals, seed events suggestive of sleep disordering events. The apparatus may be configured to compute features indicative of patterns within portions of the one or more physiological signals that are associated with the detected seed events. The apparatus may be configured to apply to a classifier, the computed features indicative of patterns of the seed events. The classifier may be trained to compute a degree of fit of the computed features to learned repetitive patterns of sleep disordering events. The apparatus may be configured to output an identification of sleep disordering event(s) corresponding with the seed events based on the computed degree of fit determined by the classifier.

Abstract: The speed and range of the transition to low lung PO2 can be optimized such that it approaches the PO2 and timing profile of reoxygenation from a hypoxic profile. However, such hypoxic “spikes” are much more difficult to implement than re-oxygenation. A solution is to control the independent variables which contribute to hypoxia in the lung. These variables may be controlled in alone or in aggregate to minimize the time required to generate a target profile of transient lung hypoxia. In particular, a rapid decrease in [dOHb] can be implemented by breathing deeply, exhaling at least a portion of the functional residual capacity, lowering the PO2 at baseline, increasing the breathing rate, and increasing the PCO2 to shift the oxygen-hemoglobin dissociation curve to the right.

Abstract: A method of determining a respiratory parameter of a patient during inspiration when receiving respiratory support and their mouth is closed comprising: providing an apparatus gas flow with a flow rate and a gas proportion to a patient, measuring a gas proportion of a composite gas inflow to the patient, determining a composite gas inflow flow rate using one or more of: apparatus gas flow gas proportion, apparatus gas flow flow rate, composite gas inflow gas proportion, ambient gas proportion, and from the composite gas inflow flow rate, determining one or more respiratory parameters.

Abstract: A system for providing continuous positive air pressure therapy is provided. The system includes a flow generator, a sensor, and a computing device. The computing device is configured to control operation of the flow generator based on sensor data. The computing device is further configured to display, on a display device, one or more questions relating to demographic and/or subjective feedback; responsive to displaying the one or more questions, receive one or more inputs indicating answers to the one or more questions; transmit the answers to a remote processing system; receive, from the remote processing system, settings determined based on the transmitted answers; and adjust control settings of the system based on the received settings.