Abstract: The invention provides a decellularized tissue hydrogel cross-linked with a polyphenol, and a method of preparing a cross-linked decellularized tissue hydrogel, the method comprising the steps of: a) providing at least one decellularized tissue hydrogel; and b) cross-linking the at least one decellularized tissue hydrogel with a polyphenol.

Abstract: The invention relates to a method for coating the balloon of a balloon catheter, wherein the surface of the balloon is wetted at least partially with a first solution containing a polysaccharide and the part of the surface of the balloon wetted with the first solution is wetted with a second solution containing an active agent. In this way, the balloon is provided with an active agent layer which is effectively applied to the inner wall of the vessel when the balloon is inflated and moreover results in a delayed long-lasting release of the active agent.

Abstract: Device surfaces are rendered superhydrophobic and/or superoleophobic through microstructures and/or nanostructures that utilize the same base material(s) as the device itself without the need for coatings made from different materials or substances. A medical device includes a portion made from a base material having a surface adapted for contact with biological material, and wherein the surface is modified to become superhydrophobic, superoleophobic, or both, using only the base material, excluding non-material coatings. The surface may be modified using a subtractive process, an additive process, or a combination thereof. The product of the process may form part of an implantable device or a medical instrument, including a medical device or instrument associated with an intraocular procedure.

Abstract: A medical system including a tube defining a lumen, a porous body connected to a distal end of the tube to be advanced to a target site within a subject. The porous body defines a plurality of openings, the plurality of openings are in fluid connection with the lumen, the porous body includes a first material and a second material, and the second material elutes from the porous body in the subject.

Abstract: A dialysis system comprising: a dialysis machine; a communication module configured to communicate using a short-range wireless technology protocol; data storage configured to store data corresponding to identities of one or more short-range wireless devices; and a processor configured to: identify presence of a short-range wireless device; and cause the dialysis machine to carry out an action when one or both of i) the presence of the short-range wireless device is identified, and ii) the presence of the short-range wireless device is no longer identified.

Abstract: This disclosure relates to dialysis systems and methods. In some implementations, a dialysis system includes a dialysis machine with a fluid line and a drain line, a blood line set configured to be connected to the dialysis machine, and a drain apparatus coupled to the dialysis machine. The drain apparatus includes a chamber configured to receive an end of a patient line of the blood line set, an inlet line, an outlet line, and a valve. The inlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the fluid line of the dialysis machine. The outlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the drain line of the dialysis machine. The valve is configured to control flow of fluid through the outlet line.

Abstract: A device controls temperature of soft water and/or permeate for dialysis applications based on the principle of reverse osmosis. The device, which can be used in a dialysis system, includes a buffer tank for heat which is coupled in terms of heat flow to a heat source and/or heat sink and receives or contains a fluid heat transfer medium. A soft water heat exchanger is connected on the primary side to the buffer tank by a pump circuit for the heat transfer medium, which is connected on the secondary side to the soft water supply line. A permeate heat exchanger is connected on the primary side to the buffer tank by a pump circuit for the heat transfer medium, which is connected on the secondary side to the permeate extraction line.

Abstract: Peritoneal dialysis admixing and/or treatment devices, methods, and systems are disclosed. The systems, methods, and devices provide high-level guarantees of sterility and employ relatively inexpensive disposable components to provide pumping. Disclosed systems, methods, and devices and features thereof are adapted for point of use generation of medicament. In particular, admixing systems that employ independently-replaceable long term concentrate are disclosed. Features are directed to assurance of sterility and accurate admixing of water and concentrate to generate ready-to-use medicaments and other benefits.

Abstract: A peritoneal dialysis (“PD”) system for detecting peritonitis is disclosed herein. In one example, the PD system includes a cycler including a pump actuator and a control unit in operable communication with the pump actuator. The PD system also includes a disposable set comprising a disposable cassette having a pump chamber. The disposable cassette is sized and arranged to be held by the cycler such that the pump chamber is in operable communication with the pump actuator. The disposable set includes a patient line and a drain line extending from the disposable cassette. The PD system further includes a temperature sensor operably coupled to one of the patient line, the drain line, or the disposable cassette to sense a temperature of effluent PD fluid removed from a patient. The control unit is configured to use the sensed temperature to form a patient peritonitis determination and communicate the peritonitis determination.

Abstract: The present invention relates to cannulae for extracorporeal circulation of blood. More specifically, it relates to cannulae used to access the vessels of a patient either to deliver or to drain blood for circulating and processing it outside the body. In particular, it relates to arterial and venous cannulae for extracorporeal circulation having slotted openings.

Abstract: A subcutaneous tunneling device includes a shaft having a bend, a catheter connector extending from a distal end of the shaft distal of the bend, and a sleeve. The catheter connector can include a body having a gripping portion, and a barbed extension distal of the body configured for insertion into a distal opening of a catheter. The sleeve is slidably mounted on the shaft and has a retracted position exposing the catheter connector for coupling the catheter to the catheter connector via the barbed extension, and an extended position covering the catheter connector and a distal end of the catheter.

Abstract: The present invention provides methods and devices for augmenting impaired glycocalyx barrier function in a subject in need thereof by contacting a sample (e.g., blood) obtained from the subject with a glycocalyx-mimetic adsorption media. The adsorption media includes glycosaminoglycan structures and, optionally, proteoglycan core proteins, which are conducive to enhancing and/or restoring the impaired glycocalyx barrier function in a sample. The contacted sample is subsequently separated from the adsorption media, producing a treated sample that can be infused into the subject. Methods and devices for treating a patient suffering from a disease associated with glycocalyx barrier dysfunction are also provided herein.

Abstract: A removable manifold for a medical/surgical waste collection system. The manifold is dimensioned to be mounted to a receiver integral with the system. The manifold includes at least one tube through which waste is drawn into a manifold cage. The tube extends through an inlet port into a void space internal to the manifold cage at an angle. The tube exits the manifold cage and is centered along an axis that is off center to the longitudinal axis of the manifold cage where it engages a complementary valve internal to the receiver. The valve regulates flow between the receiver and the down line components of the waste collection system. The valve is normally closed. When the manifold is fitted to the receiver the tube engages the valve and rotation of the manifold moves the valve to the open position allowing fluid flow from the manifold and receiver to the downstream components of the system.

Abstract: Surgical drains including a tubular mesh that is configured to distally expand from and proximally retract into a distal end of a tube or catheter. The tubular mesh may be expanded into a soft tissue body region where suction may be applied to drain fluid and other bodily material from the soft tissue body region. The tubular mesh is configured to invert along an inversion region of the tubular mesh as it is extended from and withdrawn into the tube or catheter. The distal end of the tube or catheter has a shape that promotes smooth exit of the tubular mesh out of the tube or catheter and/or entry of the tubular mesh into the tube or catheter.

Abstract: A device for producing an active ingredient solution, preferably an antiseptic wound-irrigating solution, having: a connection element designed and configured for liquid-tight connection to a container; a mandrel designed and configured for piercing a septum of a container; a reservoir containing an active ingredient in solid form, and connectable via an outlet of the reservoir in a fluid-conducting manner to the connection element; a liquid-permeable filter arranged at the outlet of the reservoir and configured to retain the active ingredient in solid form in the reservoir; a fluidic element configured to receive a liquid from a container into the reservoir, configured to dispense a liquid from the reservoir; wherein the device is configured to receive a liquid from a container into the reservoir, to dissolve the active ingredient in the liquid, and to dispense the dissolved active ingredient to a patient via the connection element.

Abstract: A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, inside the package. A nonlimiting example of the package can be a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Optionally, the package further comprises a bag, a blister, a pouch or any other vessel. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained. The said pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist is suitable for sterilization (such as for surface and/or terminal sterilization) with sterilization gas residuals being minimal and/or lower than required by ISO 10993-7.

Abstract: Disclosed in some embodiments is an electronic intravenous infusion pump provided with a disposable, insertable pump cartridge that is connectable to one or more intravenous fluid infusion sources. The infusion pump has multiple pump drivers and an electronic display with multiple display regions. Each display region includes a graphic associating information in that region with a different one of the pump drivers. Each display region also includes a machine-readable code.

Abstract: A self-compensating chucking device may be provided. The chucking device may form a portion of a latching door handle of a door of an infusion pump. The door and a housing of the infusion pump may form a clam-shell clamp that secures infusion tubing to pumping mechanisms of the infusion pump. The latching door handle may include a latching door mechanism that includes a tapered pin. The tapered pin may extend through an outer portion of a door housing, an opening in a handle of the door, and into an opening in an inner portion of the door housing. The opening in the handle of the door may have a tapered inner surface that corresponds to the taper the tapered pin to form the chucking device. The pin may include a groove configured to accept an E-clip that retains the tapered pin within the door housing.

Abstract: A medical device includes a body configured to receive and secure an IV tube that is configured to allow for the transportation of a fluid. The medical device includes a pump mechanism including a first element positioned along a first axis and configured to move in a first direction along the first axis to compress the IV tube. The pump mechanism includes a second element positioned along a second axis perpendicular to the first axis and configured to move in a second direction along the second axis and perpendicular to the first direction to provide a force against a side of the IV tube. The pump mechanism includes a third element positioned along the second axis opposite the second element and configured to move in a third direction along the second axis opposite the second direction to provide a force against another side of the IV tube.

Abstract: An infusion pump includes: a displacement sensor including: a groove portion to which an infusion tube is attachable, a detection surface exposed to the groove portion, the displacement sensor being configured to detect a pressure applied to the detection surface, a first mask portion that covers a first end of the detection surface in a width direction of the groove portion, and a second mask portion that covers a second end of the detection surface in the width direction of the groove portion.

Abstract: A drug delivery device (1), comprising a delivery unit (2) in the form of a disposable single-use part and a base unit (4) in the form of a reusable part for coupling to the delivery unit (2), the delivery unit comprising a liquid flow system for pumping liquid from a drug vial or cartridge (3) received in the drug delivery device to an outlet of the device for transcutaneous administration of a liquid drug, the base unit including at least a power source and an electronic control system, the delivery unit and base units comprising a releasable locking mechanism including a locking shoulder (30) on the delivery unit that engages a complementary locking shoulder (34) on the base unit.

Abstract: A tubing dimension measurement assembly includes a processor, a housing having an opening configured to receive a tube, the opening having an anti-slip material configured to affix the tubing dimension measurement assembly to measure a location on the tube, an emitter disposed in the housing, the emitter configured to generate an emission into a tubing pathway, and a collector disposed in the housing, the collector disposed to receive the emission from the emitter. The tubing dimension measurement assembly is configured to measure an outside diameter of the tube received in the tubing pathway without physically contacting the tube or the tubing pathway, the measurement based at least in part on the emission, and monitor a change in measurements of the outside diameter without physical contact in real time while fluid flows through the tube. Methods of operating a tubing dimension measurement assembly are also provided.

Abstract: A method and medical pump to perform a flushing procedure are provided. The medical pump is configured to execute the flushing procedure subsequent to an infusion procedure, the flushing procedure and infusion procedure lacking a specified relationship between each other until after performance of the infusion procedure. The method comprises performing an infusion procedure of a medicament with the medical pump and automatically querying in human detectable form whether to execute a flushing procedure in response to conclusion of the infusion procedure.

Abstract: The present disclosure relates to devices, systems and processes for delivering therapeutic fluids. Embodiments disclosed herein are directed to medical devices for housing a therapeutic fluid, and methods and systems for monitoring in an infusion delivery device, using a pressure sensor of the device, one or more of: (A) fill event detection; (B) fill volume detection; (C) mechanical compliance calibration/air detection of an infusion management system after fill event and priming; (D) occlusion detection after removal of insertion seal assembly; (E) detecting fluid path deployment of an infusion delivery device; (F) monitoring for occlusion detection during pump use; and (G) detecting an empty reservoir.

Abstract: The present disclosure relates to devices, systems and processes for delivering therapeutic fluids. Embodiments disclosed herein are directed to medical devices for housing a therapeutic fluid, and methods and systems for monitoring in an infusion delivery device, using a pressure sensor of the device, one or more of. (A) fill event detection; (B) fill volume detection; (C) mechanical compliance calibration/air detection of an infusion management system after fill event and priming; (D) occlusion detection after removal of insertion seal assembly; (E) detecting fluid path deployment of an infusion delivery device; (F) monitoring for occlusion detection during pump use; and (G) detecting an empty reservoir.

Abstract: The present disclosure relates to devices, systems and processes for delivering therapeutic fluids. Embodiments disclosed herein are directed to medical devices for housing a therapeutic fluid, and methods and systems for monitoring in an infusion delivery device, using a pressure sensor of the device, one or more of: (A) fill event detection; (B) fill volume detection; (C) mechanical compliance calibration/air detection of an infusion management system after fill event and priming; (D) occlusion detection after removal of insertion seal assembly; (E) detecting fluid path deployment of an infusion delivery device; (F) monitoring for occlusion detection during pump use; and (G) detecting an empty reservoir.

Abstract: The present disclosure relates to devices, systems and processes for delivering therapeutic fluids. Embodiments disclosed herein are directed to medical devices for housing a therapeutic fluid, and methods and systems for monitoring in an infusion delivery device, using a pressure sensor of the device, one or more of. (A) fill event detection; (B) fill volume detection; (C) mechanical compliance calibration/air detection of an infusion management system after fill event and priming; (D) occlusion detection after removal of insertion seal assembly; (E) detecting fluid path deployment of an infusion delivery device; (F) monitoring for occlusion detection during pump use; and (G) detecting an empty reservoir.

Abstract: An infusion pump for detection of a fluid condition in a flexible tubing is provided. The infusion pump includes a sensor positioned to obtain a value of a tubing force when the tube is received by the infusion pump, a memory storing instructions and a processor. The processor is configured to execute the instructions to generate a force-time curve representative of values of the tubing force obtained by the sensor over time, determine a time-decaying parameter associated with the tubing force characterizing the force-time curve, and determine a fluid pressure value for a fluid in the tube based at least in part on the time-decaying parameter, a material of the tube, a dimension of the tube, and a use history of the tube. A method for using an infusion pump is also provided.

Abstract: The present disclosure relates to devices, systems and processes for delivering therapeutic fluids. Embodiments disclosed herein are directed to medical devices for housing a therapeutic fluid, and methods and systems for monitoring in an infusion delivery device, using a pressure sensor of the device, one or more of: (A) fill event detection; (B) fill volume detection; (C) mechanical compliance calibration/air detection of an infusion management system after fill event and priming; (D) occlusion detection after removal of insertion seal assembly; (E) detecting fluid path deployment of an infusion delivery device; (F) monitoring for occlusion detection during pump use; and (G) detecting an empty reservoir.

Abstract: Infusion systems are provided that include an infusion pump and a fluid ingress protection assembly. The fluid ingress protection assembly includes a cover assembly having an outer surface and an inner surface, a perimeter gasket disposed within a raised perimeter on the outer surface of the cover assembly, a lens coupled to the outer surface of the cover assembly, a circuit assembly coupled to the outer surface of the cover assembly, a switch assembly coupled to the circuit assembly, a shield assembly coupled to the switch assembly, the shield assembly comprising an electrostatic discharge shield and an overlay assembly coupled with the shield assembly. Methods of assembling an infusion system are also provided.

Abstract: Methods, devices and systems are disclosed for inter-app communications between software applications on a mobile communications device. In one aspect, a computer-readable medium on a mobile computing device comprising an inter-application communication data structure to facilitate transitioning and distributing data between software applications in a shared app group for an operating system of the mobile computing device includes a scheme field of the data structure providing a scheme id associated with a target software app to transition to from a source software app, wherein the scheme id is listed on a scheme list stored with the source software app; and a payload field of the data structure providing data and/or an identification where to access data in a shared file system accessible to the software applications in the shared app group, wherein the payload field is encrypted.

Abstract: A model-based control scheme consisting of either a proportional-integral-derivative (IMC-PID) controller or a model predictive controller (MPC), with an insulin feedback (IFB) scheme personalized based on a priori subject characteristics and comprising a lower order control-relevant model to obtain PID or MPC controller for artificial pancreas (AP) applications.

Abstract: A system includes one or more processors and one or more processor-readable storage media storing instructions which, when executed by the one or more processors, cause performance of obtaining an insulin-on-board (IOB) value, wherein the IOB value is a quantity of insulin remaining in a patient following delivery of a bolus of insulin, scaling a total daily dose (TDD) value by a factor, to generate a result having a value that is less than the TDD value, based on determining that the IOB value is greater than the result, identifying a condition in which the patient's glucose level will continue to decrease after suspension of basal insulin dosage delivery, and responsive to identifying the condition, causing performance of an action for preventing the patient's glucose level from falling into a hypoglycemic range in combination with the suspension of basal insulin dosage delivery.

Abstract: A medical device may comprise: a first inlet for receiving a first fluid; a second inlet for receiving a second fluid; and a mixing body including a first body defining a first lumen and a second body disposed within the first lumen. The first lumen may be in fluid communication with the first inlet such that the first lumen receives the first fluid from the first inlet. The second body may define a second lumen. The second lumen may be in fluid communication with the second inlet, such that the second lumen receives the second fluid from the second inlet. A radially outer surface of the second body may have a plurality of openings, such that the first lumen and the second lumen are in fluid communication via the plurality of openings.

Abstract: The present disclosure provides medical products and methods including an applicator tip for connection to a syringe. The applicator tip is advantageous when dispensing viscous fluids, such as adhesives and/or sealants.

Abstract: An injection device is provided, including a syringe having a barrel and a flange and a backstop configured to be coupled with the syringe adjacent to the flange. The backstop includes an inner surface generally extending around at least a portion of the syringe, wherein the inner surface includes at least one protrusion extending away from the inner surface and configured to engage the flange and/or the barrel to permit or promote airflow through a space between the inner surface and the syringe.

Abstract: A plunger stopper configured for attachment with a plunger rod for use with a within a syringe barrel for high dose accuracy drug delivery. The stopper having a first portion formed from a first material and a second portion formed from a second material, wherein the second material has a greater rigidity than the first material and wherein the second portion is configured to be attached to a plunger rod. The second material can be in the form of an insert which functions to reduce the amount of distortion of the stopper during use, reduce air bubble size variation from fill to fill, maintain a seal with the inner wall of the syringe barrel with lower contact pressure in a resting state and reduce the amount of hysteresis of the stopper. The stopper can be adapted for use with infusers, pens, and other types of auto-injectors.

Abstract: A sliding cover for a liquid delivery device, such as a cap (100) for a pen injector (200), incorporates a set of sensors including a first optical sensor (110) with an output which changes during uncapping or capping motions on passing of a plunger (220) of the pen injector. This output is used together with at least one additional sensor output to determine the position of the plunger along a cylinder (210) of the liquid delivery device. By monitoring changes in the plunger position, the quantity of dosages delivered by the liquid delivery device can be determined, displayed, stored and/or transmitted to an external device for further data processing or storage.

Abstract: The present invention relates to a handheld mechanical injection device by which set doses of a liquid medicament can be injected from a medical reservoir. The medicament is expelled through an injection needle by release of a power reservoir in the device, the power reservoir being fully or partially released by actuation of a user operable release member being positioned at or near an upper end of the injection device, the upper end being that end of the injection device which is opposite the injection needle.

Abstract: An autoinjector comprises a housing, a product container, a displaceable needle protection sleeve, a plunger rod displaceable by a preloaded discharge spring, a dose setting element with at least two different rotational positions relative to the housing, and a dosing sleeve. The dosing sleeve or the plunger rod has a dose selection stop, and the other has at least one dosing stop. By rotating the dose setting element, the dosing sleeve or the plunger rod is rotated relative to the other. Upon displacement of the needle protection sleeve, the spring displaces the plunger rod, whereby, if the dose setting element is in the first rotational position, the dose selection stop and the first dosing stop strikes against each other, and, if the dose setting element is in the second rotational position, one of the dose selection stop and the first dosing stop is or can be moved past the other.

Abstract: A rigid needle shield assembly (40) for covering the needle of a syringe including a rigid shield (42) having an open proximal end (44), a distal end (46), an exterior sidewall (47), and an interior sidewall (48), as well as a flexible needle sheath (52) having an open proximal end (54), a closed distal end (56), an exterior sidewall (57), and an interior sidewall (58). The rigid needle shield assembly (40) also includes an RFID tag (60) having at least a first antenna leg (65A) and a second antenna leg (65B). The flexible needle sheath (52) and the RFID tag (60) are housed within the rigid shield (42). Furthermore, the RFID tag (60) is positioned between the interior sidewall (48) of the rigid shield (42) and the exterior sidewall (57) of the flexible needle sheath (52), and the first antenna leg (65A) and the second antenna leg (65B) extend along a length of the rigid shield (42) between the interior sidewall (48) of the rigid shield (42) and the exterior sidewall (57) of the flexible needle sheath (52).

Abstract: A needle shield remover assembly for a wearable injector includes a needle shield having a body defining an opening configured to receive a patient needle of the wearable injector, with the body of the needle shield having an extension portion having a top surface and a bottom surface positioned opposite the top surface, and a needle shield remover having a first portion and a second portion. The needle shield remover has an unassembled position where the first portion is spaced from the second portion and an assembled position where the first portion is connected to the second portion, with the first portion and the second portion of the needle shield remover defining a needle shield surface configured to engage the top surface of the extension portion of the needle shield when the needle shield remover is in the assembled position.

Abstract: A medicament delivery device (1) comprising: a tubular housing (3) extending along an axis (L), wherein the housing (3) has a proximal end (3a) provided with a proximal opening, and a distal end (3b), a delivery member cover (5) configured to be axially movable along the axis (L) relative to the housing (3) from an extend position, towards which the delivery member cover (5) is biased and in which the delivery member cover (5) protrudes from the proximal opening, to a retracted position, and a drive assembly arranged in the housing (3) and configured to be activated to initiate medicament delivery by movement of the delivery member cover (5) from the extended position towards the retracted position, wherein the housing (3) has an outer surface provided with a plurality of ribs (7) extending from the proximal end (3a) in a direction towards the distal end (3b).

Abstract: Medication delivery methods, devices and systems are provided. The medication delivery device includes a retractable sheath mechanism connected to a distal end of the device. The retractable sheath mechanism is axially movable between a first position to cover a needle attached to the distal end and a second position to expose the needle with an adjustable protrusion length. The retractable sheath mechanism includes one or more skin sensors disposed on an end surface thereof to detect skin before and during injection. In some cases, a needle carousel is provided to connect to the distal end of the device. The needle carousel supports multiple needle capsules each including a needle.

Abstract: A hypodermic needle destruction device includes a main body housing a power source and a controller; a recess for receiving, in use, a needle destruction module; and means for retaining the needle destruction module at least partially within the recess. The needle destruction module has clamping and tip electrodes that respectively clamp and axially compress a hypodermic needle, and a containment tube that inhibits bowing of the needle. When a current is passed through the needle via the electrodes and an axial force applied, the needle is sterilised and blunted.

Abstract: A device for preventing wrong route/unintentional/unauthorized injection into catheters and connectors for intravascular, hypodermic, and neuraxial applications includes a female end (connector) connected to a male end (connector), and a detecting mechanism for detecting the insertion of an external male end (connector) such as a syringe into the female end of the device. The device may further include an input/output (I/O) interface coupled to the detecting mechanism. The detecting mechanism is further configured to urge the I/O interface to generate an alarm responsive to the detection of the insertion of a male connector into the female end of the device. By connecting this device to any female ends in which we need an extra layer of security we can protect that female connection from possible errors. This device is applicable in any situations in which we need more caution such as preventing wrong route drug injections.

Abstract: A power supply section for an e-vaping device includes a sensor housed in a housing, a sensor holder holding the sensor, the sensor holder disposed in the housing to divide the housing into a first portion and a second portion, and the sensor and the sensor holder configured to substantially prevent air flow from the first portion into the second portion, and a power source disposed in the second portion. The construction of this unit insures that gases that may be produced by outgassing of the battery cell will be vented to the environment and that those gases will be isolated from the air that is mixed with the vaporized e-liquid and inhaled by the user.

Abstract: The present disclosure provides for a flow therapy apparatus that can implement one or more closed loop control systems to control the flow of gases of a flow therapy apparatus. The flow therapy apparatus can monitor blood oxygen saturation (SpO2) of a patient and control the fraction of oxygen delivered to the patient (FdO2). The flow therapy apparatus can automatically adjust the FdO2 in order to achieve a targeted SpO2 value for the patient.

Abstract: A breathing device with carbon dioxide compensation function includes an air source pipeline, a low pressure oxygen source pipeline, a high pressure oxygen source pipeline, a carbon dioxide source pipeline, a gas supply pipeline all of which are set in a ventilator and corresponding to an air source, a lower pressure oxygen source, a high pressure oxygen source and a carbon dioxide source respectively; and a breathing pipeline which is set outside the ventilator. The breathing device further includes a carbon dioxide flow regulation system for detecting and regulating carbon dioxide in the breathing gas which is transported by the breathing device for patients.

Abstract: A method for intubating a patient with a magnetic bougie system is provided. The method includes inserting a bougie through an oral cavity of the patient and advancing the bougie to a trachea of the patient. The method further includes attracting a metal tip of the bougie to a magnet. The magnet is positioned externally to the trachea of the patient. The magnet is fixed to a base holder. The method further includes confirming a position of the bougie with one or more sensors. The method further includes inserting an endotracheal tube through the oral cavity of the patient and advancing the endotracheal tube to the position of the bougie.