Abstract: An arrangement of drug delivery devices is provided with interchangeable members and non-interchangeable members.

Abstract: Described is a catheter patency maintenance device comprising of a flush syringe, an elongate plunger rod with a stopper slidably positioned within the barrel, a cap, disinfectant and a valve movable between an open position and a closed position. The valve may include a valve stem and/or openings in the valve to permit fluid flow. Methods of using the flush syringe assemblies are also described.

Abstract: Embodiments of the present invention disclose a method of cosmetic or biomedical application of a device, comprising a self-contained syringe device comprising an inner syringe included within an outer syringe and wherein a filter is attached inside the outer syringe barrel; wherein the filter comprises a filter material that prevents premature filter collapse where the filter material is optionally coated to increase stiffness, and wherein liposuctioned adipose tissue is collected and purified inside the syringes.

Abstract: Apparatuses and methods for continuous injection of fluid, in some examples the apparatuses may include a manifold, a pair of reciprocating pistons, and an actuation control that may apply both suction (aspiration) and injection of fluid as part of the same actuation. The apparatuses and methods may be configured to simplify operation of a continuous fluid injection apparatus, including operations that include an aspiration an injection of fluid to confirm the absence/presence of blood prior to injection.

Abstract: A puncture needle for medical use includes: a main body that is rod-shaped and that comprises a distal end portion comprising a blade surface. The blade surface includes: a first blade surface portion that extends so as to incline with respect to a central axis of the main body, and a second blade surface portion that is formed on a back side of the first blade surface. A blade edge having a needle tip at one end is formed by a ridge line where the first blade surface portion meets the second blade surface portion. The first blade surface portion is constituted by a concave surface that is concave in a side view of the main body.

Abstract: The present invention relates to an infusion fluid warmer comprising a heat exchanger and first and second printed circuit boards comprising respective integrally formed electrically resistive patterns acting as heating elements. The integrally formed electrically resistive patterns are heated by supply of electrical power and thermally coupled to a heat exchanger to warm an infusion fluid flowing through a fluid passage of the heat exchanger.

Abstract: A system for delivering one or more therapeutics to a region of the ear, the region being internal to a tympanic membrane. The system includes a canal guide configured to be inserted within and fittingly engaged with walls of the ear canal and needle assembly having a flexible shaft sized to extend through the canal guide. The canal guide provides alignment of the needle assembly within the ear canal relative to the tympanic membrane. The canal guide includes a viewing lumen extending between a proximal end to a distal-most end of the canal guide and is sized to remain external to the tympanic membrane. The canal guide includes a guide lumen extending to a distal opening near the distal-most end of the canal guide. The guide lumen curves from a first axis to a second axis. Related devices, systems, and methods are provided.

Abstract: Described is an electronics assembly with pressure or force sensing capabilities for use in a drug delivery device. The electronics assembly includes a processor, a sensor arranged to measure the force applied by a drive mechanism to drive a medicament from a cartridge, a wireless module to which an external device can be paired, a power module arranged to supply power to the assembly, and memory storing instructions for the processor to perform. The instructions include receiving a measurement signal during the drug delivery operation, and determining if the dose of the medicament was expelled from the drug delivery device based on the received measurement signal.

Abstract: A temporary, removable mechanical circulatory support heart-assist device has at least two propellers or impellers. Each propeller or impeller has a number of blades arranged around an axis of rotation. The blades are configured to pump blood. The two propellers or impellers rotate in opposite directions from each other. The device can be configured to be implanted and removed with minimally invasive surgery.

Abstract: Catheter blood pumps that include an expandable pump portion, which include an expandable impeller housing. The housings include an expandable blood conduit that defines a blood lumen, and one or more pluralities of expandable struts extending axially from an end region of the expandable blood conduit. At least one of the pluralities of struts are non-unitary with a blood conduit at the end region.

Abstract: A method of managing a speed of implantable blood pump. The implantable blood pump is in communication with an internal battery and a transcutaneous energy transfer system (TETS). The method includes starting the pump at a programmed set speed. The speed of the pump is decreased from the programmed set speed to a minimum set speed if either a capacity of the internal battery is less than a predetermined reserve level and TETS power is unavailable, or there is insufficient TETS power to maintain the programmed set speed. The speed of the pump is progressively decreased from the programmed set speed if there is insufficient power to maintain the programmed set speed.

Abstract: A TETS having an external controller having a power source, a transmission coil in communication with the external controller, a receiving coil configured for transcutaneous inductive communication with the transmission coil, and an implantable controller in communication with the receiving coil and an implantable blood pump. The implantable controller has a battery configured to receive power from the receiving coil and the external controller is configured to categorize power transfer states based on predetermined thresholds of efficiency and power demand, and user display states (associated with optional configurable notifications) based on the power transfer states and predetermined temperature thresholds of the transmission coil.

Abstract: An external coil system for a transcutaneous energy transfer system (TETS), the external coil being configured to transfer energy sufficient to power and implantable blood pump. The system includes a housing containing the external coil, the housing includes a thermal insulating base, the external coil being partially disposed within the thermal insulating base and a thermally conductive plastic, the external coil being partially disposed within the thermally conductive plastic.

Abstract: A device for functional electrical stimulation, including a garment mountable on a user's body part, an assembly having a socket and an electrode in turn having electrode pads and a stimulator with a controlling mechanism for activating/deactivating stimulating electrical signals to be provided to at least some of the electrode pads. The garment defines a hollow area configured to receive the socket, the socket configured to house the stimulator. In use of the device, a first portion of the electrode is in contact with an inner surface of the garment, the electrode pads are in a fixed position with respect to the garment, and a second portion of the electrode is in contact with a surface of the socket for receiving the stimulating electrical signals delivered by the stimulator. A system may include the device and a sensor configured to be positioned on either user or in proximity thereto.

Abstract: A wearable defibrillator for monitoring treatable arrhythmias in a patient in the presence of background noise includes a plurality of sensing electrodes configured to generate ECG data, one or more therapy pads, one or more audio devices, and one or more processors. The one or more audio devices include a microphone configured to detect background noise and a speaker. The one or more processors are configured to determine, from at least the ECG data, whether the patient is experiencing a treatable arrhythmia; cause, via the speaker, an audible alarm in response to determining that the patient is experiencing the treatable arrhythmia; delay a delivery of treatment to the patient in response to determining that at least the predetermined level of background noise exists; and during the delay, perform at least one of obtaining additional data or running an additional test to verify that the patient is experiencing the treatable arrhythmia.

Abstract: A wearable cardiac monitoring and treatment device for improved skin interface contact and easy assembly and disassembly includes a garment including an inner surface and an outer surface, ECG sensing electrodes, and at least one stiffener forming a section of the garment in proximity to one or more of the ECG sensing electrodes. The at least one stiffener is configured to resist rotation or pulling away of the one or more of the ECG sensing electrodes from a patient's torso. The device includes therapy electrodes, at least one separate module including a therapy delivery circuit, and a controller. The device includes compartments configured to receive the therapy electrodes and at least one separate module, and retention loops configured to route external wires extending between at least the therapy electrodes and at least one separate module, where the compartments and retention loops are disposed on the outer surface of the garment.

Abstract: A subcutaneously implantable device includes a housing, a clip attached to a top side of the housing, a first prong with a proximal end attached to the housing and a distal end extending away from the housing, and a first electrode on the first prong. The clip is configured to anchor the device to a muscle, a bone, and/or a tissue. The first prong is configured to contact a heart. The first electrode is configured to contact the heart. Sensing circuitry in the housing that is configured to sense an electrical signal from the heart, and therapeutic circuitry in the housing is in electrical communication with the first electrode and is configured to deliver electrical stimulation to the heart through the first electrode.

Abstract: A subcutaneously implantable device is implantable into a body of a patient, and includes a prong and an electrode. The prong has a contact portion at or adjacent to a distal end thereof that is configured to contact an organ. The prong is constructed to apply pressure to the organ with spring action so as to maintain contact between the contact portion and the organ without fixing the contact portion to the organ. The electrode is provided at the contact portion of the prong, is configured to contact the organ, and is electrically coupled or couplable with circuitry that is configured to provide monitoring, therapeutic, and/or diagnostic capabilities with respect to the organ.

Abstract: Presented herein are dissolution barriers for use with tissue-stimulating prostheses. As described further below, a tissue-stimulating prosthesis comprises a stimulating assembly including an elongate insulating carrier member and a plurality of electrode contacts disposed along the carrier member. A continuous dissolution barrier is disposed on the surface of the stimulating assembly so as to substantially encapsulate/enclose the plurality of electrode contacts and the carrier member. The continuous dissolution barrier is configured to inhibit in situ dissolution of the plurality of electrode contacts.

Abstract: A temporary pacing lead has an atraumatic curled distal region with multiple cathodes and distal pressure measurement to allow positioning and repositioning within the heart chamber without fluoroscopic or echo guidance. The curled distal region provides definite contact with two opposing walls of the ventricular chamber to ensure electrical signal capture without trauma to the endocardial surface. A stylet located in the pacing lead lumen assists in introducing, placing, and removing the pacing lead from the heart. The flexible distal region provides safe removal of the temporary lead following completion of use.

Abstract: A delivery device for delivering a pacing lead to the His bundle of a patient's heart includes an elongated sheath having a distal end, and a plurality of mapping electrodes positioned at the distal end. The distal end of the sheath may have a distal end face, and the mapping electrodes may include two electrodes that diametrically oppose one another at a position exposed on or spaced from the distal end face. The sheath includes a plurality of flexible sections spaced apart from one another, and a pull wire that causes the sheath to deflect from a substantially straight configuration to a dual hinged curved configuration that maneuvers and positions the electrodes in the vicinity of the bundle of His. The sheath may include a PTFE liner having axially oriented, platelet-like fibril features that enable the sheath to be split along its length from a proximal end to the distal end.

Abstract: An adaptive transdermal iontophoretic introduction system for the beauty field is provided. Specifically, the system includes an iontophoretic introduction system, and a control and drive electronic system. The control and drive electronic system includes an operation system, a central processing system, an electrode drive system, a sensing system and a data communication system. The adaptive transdermal iontophoretic introduction system provides personalized transdermal drug delivery according to the actual condition of a user's skin, optimizes the dose, depth and speed of the transdermal drug delivery in real time, and maximizes the product usage effect and safety.

Abstract: A noninvasive ergonomic self-use device including a plurality of electrodes and a processor in electrical communication with the electrodes, the processor is configured to switch two or more of the electrodes between at least an ECG mode of operation in which the electrodes receive user body signals and an EPG mode in which the electrodes generate electrical pulses for stimulating the abdominal muscles of the user.

Abstract: A system may include at least one lead, a stimulation waveform generator, and a controller. The controller may be programmed to implement a process to suggest at least one electrode to be used to stimulate the nerve root. A therapeutic window may be determined for each electrode. For each electrode determining the therapeutic window may include applying stimulation, determining a first stimulation threshold for the applied stimulation to cause a first physiological effect, determining a second stimulation threshold for the applied stimulation to cause a second physiological effect, and determining a difference between the first stimulation threshold and the second stimulation threshold, wherein the difference is the therapeutic window. The process may further include determining at electrode(s) with a minimum value for the therapeutic window, and suggesting the electrode(s) to be used to stimulate the nerve root based on the determined electrode(s) with the minimum value.

Abstract: An exemplary neuromodulation device may be configured to treat a pain syndrome based on applying a predetermined waveform to a patient, while measuring patient physiological parameters in a feedback loop using sensors and triggering a change of the predetermined waveform to an adapted waveform, in response to detecting a change in the tolerance of the pain syndrome to the predetermined waveform. The neuromodulation device may be, for example, a Spinal Cord Stimulation Implantable Pulse Generator (SCS IPG). The SCS IPG may be configured to measure signal characteristics of an applied waveform using input electrodes while the same waveform is applied to a patient using output electrodes. The SCS IPG may compare the measured signal characteristics to signal characteristics of a predetermined waveform to determine if the applied waveform matches the predetermined waveform. The SCS IPG may send an indication to an authorization server that the predetermined waveform is in use.

Abstract: An exemplary neuromodulation device may be configured to treat a pain syndrome based on applying a prescribed waveform to a patient, while measuring patient physiological parameters in a feedback loop using sensors and triggering a change of the prescribed waveform to an adapted waveform, in response to detecting a change in the tolerance of the pain syndrome to the prescribed waveform. The neuromodulation device may be, for example, a Spinal Cord Stimulation Implantable Pulse Generator (SCS IPG). The SCS IPG may be configured to receive a digital indication to apply the prescribed waveform to the patient using output electrodes until a predetermined time while measuring signal characteristics of the applied waveform using input electrodes. The SCS IPG may compare the measured signal characteristics to signal characteristics of a predetermined waveform to determine if the applied waveform matches the predetermined waveform and send an indication the predetermined waveform is in use.

Abstract: The invention provides methods for treating a neurological disorder or deficit, such as tinnitus and phantom limb pain.

Abstract: An automated method of controlling neural stimulation. A neural stimulus is applied to a neural pathway in order to give rise to an evoked action potential on the neural pathway, and the stimulus is defined by at least one stimulus parameter. A neural compound action potential response evoked by the stimulus is measured. From the measured evoked response a feedback variable such as observed ECAP voltage (V) is derived. A feedback loop is completed by using the feedback variable to control the at least one stimulus parameter value for a future stimulus. The method adaptively compensates for changes in a gain of the feedback loop caused by electrode movement relative to the neural pathway. A compensating transfer function is applied to the feedback variable, the compensating transfer function being configured to compensate for both (i) a distance-dependent transfer function of stimulation, and (ii) a distance dependent transfer function of measurement which is distinct from (i).

Abstract: A method is described, which provides electrical stimulation to a person, where the current flows from a subcranial electrode, through a target brain region, through a separate conductive path, and back to a subcutaneous electrode, and where the parameters of the electric current pulses are set to influence the resonant properties of the brain.

Abstract: Devices, systems, and techniques include determining spatial relationships between electrodes implanted within a patient. In one example, a medical device delivers, via a first electrode, an electrical stimulus and senses, for each other electrode, a respective electrical signal indicative of the electrical stimulus. The medical device determines, for each other electrode, a respective value for each respective electrical signal. The medical device determines, based on the respective values for each respective electrical signal and values of tissue conductivity of tissues of the patient interposed between the first electrode and the other electrodes, spatial relationships between the first electrode and each other electrode of the plurality of electrodes.

Abstract: An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to access at least one of: patient input, clinician input, or automatic input, use the patient input, clinician input, or automatic input in a search method. The search method may be designed to evaluate a plurality of candidate neuromodulation parameter sets to identify an optimal neuromodulation parameter set and to program a neuromodulator using the optimal neuromodulation parameter set to stimulate a patient.

Abstract: An intracardiac pacemaker system is configured to produce physiological atrial event signals by a sensing circuit of a ventricular intracardiac pacemaker and select a first atrial event input as the physiological atrial event signals. The ventricular intracardiac pacemaker detects atrial events from the selected first atrial event input, determines if input switching criteria are met, and switches from the first atrial event input to a second atrial event input in response to the input switching criteria being met. The second atrial event input includes broadcast atrial event signals produced by a second implantable medical device and received by the ventricular intracardiac pacemaker.

Abstract: Techniques for pairing an external device such as a clinician programmer (CP) to an implantable medical device (IMD) are disclosed, which involve use of a remote controller (RC) paired to the IMD. The RC is placed into a CP pairing mode, which acts differently depending on the type of IMD paired to the RC. If the IMD is RF based, the CP pairing mode places the IMD in a pairing mode, thus allowing the CP to connect directly with the IMD via a RF telemetry protocol. If the IMD is magnetic-induction based, the CP pairing mode causes the RC to advertise its presence to the CP, allowing the CP to connect to the RC via the RF telemetry protocol. Because the RC is also paired with the IMD via a magnetic induction telemetry protocol, the RC acts as a passthrough device to allow communications between the CP and the IMD.

Abstract: Systems, apparatus, methods and computer-readable storage media facilitating trusted pairing between an implantable medical device (IMD) and an external device are provided. In one embodiment, an IMD includes a housing configured to be implanted within a patient, a memory and circuitry within the housing and a processor that executes executable components stored in the memory.

Abstract: Embodiments herein relate to systems for tracking and maintaining the integrity of patient device data over extended periods of time. In a first aspect, a medical device system is included having an implantable device that can include a control circuit, a communication circuit, and one or more sensors. The system can also include an external device including a control circuit and a communication circuit. The external device can be configured to receive patient data from the implantable device and execute a hashing operation on units of received patient device data and one or more previous digest packets to create new digest packets. The external device can be configured to store the new digest packets and forward digest packets onto another device of the medical device system when requested to allow patient data to be authenticated. Other embodiments are also included herein.

Abstract: A subcutaneously implantable device includes a housing, a clip attached to a top side of the housing that is configured to anchor the device to a bone, and an electrode that is configured to contact an organ. The clip includes a top portion that is rigid, a bottom portion that is rigid, and an intermediate portion between the top portion and the bottom portion that is configured to permit movement of the top portion with respect to the bottom portion and thereby apply force onto the bone between the top portion and the bottom portion.

Abstract: A lead adapter for a patient treatment system comprises a housing having a plurality of inlets, each inlet being segregated from an immediately adjacent inlet by a housing intermediate wall. A plurality of electrical contact assemblies residing in the housing are electrically connected to a respective one of a plurality of electrical contact posts. Each contact post has an exposed terminal portion residing in one of the plurality of inlets. A header is movably secured to the housing to selectively open and close the housing. With the header in an open position, an implantable lead is movable into a longitudinally extending opening in the header. The header is then manipulatable into a closed position to move an electrical contact of the lead into contact with a respective one of the electrical contact assemblies electrically connected to a respective one of the electrical contact posts.

Abstract: Certain medical devices, such as auditory prostheses, have an implantable portion and an external portion. The implantable portion and external portion each include a transmission/receiver coil that communicates signals between the two portions. The implanted coil is implanted about the ear canal while the external coil is disposed about the pinna or in the ear canal itself. The proximity of the two coils allows for signal transmission between the implantable and external portions.

Abstract: Methods and systems that analyze electrocardiogram (ECG) data to identify whether it would be beneficial for a caregiver to administer an electric shock to the heart in an effort to get the heart back into a normal pattern and a consistent, strong beat. By conducting a running check for conditions that are pre-validated by a comprehensive patient database to have high predictive value (e.g., with a low false-positive rate), a shockable rhythm can be identified fast (e.g., less than 6 seconds, less than 3 seconds, possibly in less than a second) and without having to analyze ECG data for longer time segments than would otherwise be required using conventional methods.

Abstract: A serviceable wearable cardiac treatment device for continuous extended use by an ambulatory patient includes a garment and a device controller. The garment is configured to dispose therein a plurality of ECG sensing and therapy electrodes. The device controller is configured to be in separable electrical communication with the plurality of ECG sensing and therapy electrodes. The device controller includes an impact-resistant energy core, including a frame and capacitor(s) permanently bonded to the frame. The device controller includes a critical function circuit board, including critical function processor(s) and circuitry, and a non-critical function circuit board, including non-critical function processor(s) and circuitry. The critical function circuit board is in electrical communication with the capacitor(s) and configured to control critical operations of the device controller regardless of operability of the non-critical function circuit board.

Abstract: A magnetic bio-therapy device may include a ring having an inside diameter and an outside diameter and a bore defined by the inside diameter. In addition, the device may include a plurality of permanent magnets each having a magnetic field circumferentially spaced around the ring between the inside diameter and the outside diameter where each of the plurality of permanent magnets is oriented such that the magnetic field of each of the permanent magnets is directed in a predetermined direction.

Abstract: The disclosure relates generally to methods for treating or slowing progression of a tumor, a neurodegenerative disease or a cognitive impairment, and for improving cognition, comprising administration of light therapy. The disclosure also relates to methods for activating oral stem cells, comprising administration of light therapy. Further provided herein are methods for improving cognition, comprising administering to the oral cavity of a subject in need thereof an effective amount of light. Additionally provided herein are methods for treating autism or Asperger's syndrome, comprising administering to the oral cavity of a subject in need thereof an effective amount of light.

Abstract: A treatment device includes a pulsed particles accelerator and a processor for controlling the latter to deliver a treatment plan by deposition at HDR of charged particles into a flash volume (Vht) by PBS. To shorten the time for depositing a target dose (Dti) into the cells spanned by the flash spots (Si) of the flash volume (Vht), the flash spots are combined into k sets of n flash spots (Si). After depositing a jth pulse dose (Dij) into the cells spanned by a ith flash spot (Si) the beam commutes from the ith flash spot (Si) to a next (i+1)th flash spot according to a flash scanning subsequence to deposit a jth dose into the cells spanned by each of the subsequent flash spots of the flash scanning subsequence, until returning to the ith flash spot to deposit a (j+1)th dose (Di(j+1)), and so on When all the cells spanned by all the flash spots of a set have received their corresponding target dose, the beam moves to a next set of combined flash spots and repeats the foregoing pulse deposition steps.

Abstract: A method of treatment including: selecting tissue to be exposed to radiation for gradual closure of one or more blood vessel within the tissue to be exposed radiation; selecting radiation levels to promote gradual constriction of the one or more vessel; exposing the tissue to be exposed radiation to selected radiation levels.

Abstract: A casing holding one or more brachytherapy seeds for implanting in a patient, which in turn carry atoms of a radioactive element for radiotherapy treatment is filled with a viscous liquid in a manner preventing radiation from the one or more brachytherapy seeds from exiting the casing. The casing may include a metallic or non-metallic elongated tube configured for insertion into tissue or a vial for delivering a seed to a physician for insertion into a needle.

Abstract: New compositions of tissue-equivalent three-dimensional polymer gel dosimeters based on acrylamide (AAm), N-isopropylacrylamide (NIPAM), N-(Hydroxymethyl)acrylamide (NHMA), diacetone acrylamide (DAAM) and N-Vinylcaprolactam (NVCL) monomer with ethylene glycol co-solvent have been introduced in this invention for radiotherapy dosimetry. The dosimeter was irradiated with 6 and 15 MV linear accelerator at absorbed doses up to 10 Gy. The nuclear magnetic resonance (NMR) spin-spin relaxation rate (R2) for water proton surrounding polymer formation was used to investigate the degree of polymerization of the five gels. The effect of additives, dose rate, radiation energy, stability of the polymerization after irradiation, were investigated on the dose response of the gels.

Abstract: A radiation treatment plan three-dimensional dose prediction machine learning model is trained using a training corpus that includes a plurality of radiation treatment plans that are not specific to a particular patient and wherein the training corpus includes some, but not all, possible patient volumes of interest. Information regarding the patient (including information regarding at least one volume of interest for the patient that was not represented in the training corpus) is input to the radiation treatment plan three-dimensional dose prediction machine model. The latter generates predicted three-dimensional dose distributions that include a predicted three-dimensional dose distribution for the at least one volume of interest that was not represented in the training corpus.

Abstract: A radiation treatment plan for a particular patient is optimized that provides corresponding resultant radiation dosing information. Such optimization can include, by one approach, calculating a corresponding influence matrix. Upon detecting at least one manual edit to at least one spot weight that corresponds to the radiation treatment plan, these teachings can provide for responsively generating new radiation dosing information in at least near real-time as a function of a corresponding influence matrix.

Abstract: Patient information for a particular patient, radiation treatment information, and information regarding a particular radiation treatment platform that includes at least one multi-leaf collimator are each accessed. These teachings then provide for optimizing a radiation treatment plan to dose at least one treatment volume in the particular patient using the particular radiation treatment platform as a function of the patient information, the radiation treatment information, and the information regarding the particular radiation treatment platform, wherein the optimizing does not include optimizing movement of any leaves of the multi-leaf collimator.

Abstract: The present disclosure is directed towards a treatment planning system for use in a stereotactic radiotherapy system. In particular, the disclosed systems and methods may be used for generating a treatment plan and/or verifying an existing treatment plan. Moreover, the disclosed systems and methods may be suitable for use in a clinical setting. A method for verifying a treatment plan of a stereotactic radiotherapy device may include the steps of receiving a treatment plan, generating a second treatment plan by applying a modified monte-carlo method to regions of interest in the treatment plan, and identifying discrepancies between the received treatment plan and the generated second treatment plan.