Abstract: A probe can be situated within a tissue to perfuse one or more materials, collect material in response, and pass the collected material to a microdialysis probe situated external to the tissue based on fluid flow by electroosmosis. Perfusion and collection can be via orifices that are offset laterally and along a tissue depth. Variation of perfusion by varying materials perfused or rate of perfusion can be used to determine perfusion rates or other time-dependencies., concentrations of chemical species and rates of reactions of chemical species in the tissue.

Abstract: An installation unit of an analyte detection device includes a housing. A parallel slider module is arranged inside the housing and can slide relative to the housing. An analyte detection device is arranged at the front end of the parallel slider module. The analyte detection device includes a shell, a transmitter, a sensor and an internal circuit arranged in the shell and electrically coupled with the sensor. The shell connects with the parallel slider module releasably. An auxiliary-needle module is used to pierce the sensor under the use's skin. When a triggering module moves towards the near end relative to the housing, the installation action is implemented. An elastic module is used to provide the elastic force required to implement the installation action.

Abstract: An analyte detection device with battery and shell integrated is provided. The battery cavity is installed in the outer shell, the battery cavity includes the cavity shell, the diaphragm, the electrolyte, the anode plate, cathode plate and the conductive strip, the electrolyte isolation layer is also arranged inside the cavity shell, to form the structure of battery and outer shell integration, the shape and size of the analyte detection device are no longer limited by the shape and size of the shell of the button battery, and the shape and size of the battery cavity can be optimized according to the miniaturization design requirements of the analyte detection device to improve user experience.

Abstract: System and method for realizing communication connection of analyte detection device are disclosed. When the communication connection is not established and the communication connection has been established, the analyte detection device transmits two different signals respectively, namely the first signal and the second signal. The remote equipment searches and identifies the nearby signals, and executes different communication connection procedures according to the signals. When only one first signal is recognized by the remote equipment, it can be judged that the analyte detection device transmitting the signal is the analyte detection device to be established with communication connection, and the communication connection can be established directly without the user manually inputting or scanning the equipment code, which simplifies the process of establishing the communication connection, avoids the user inputting or scanning the wrong equipment code, and improves the user experience.

Abstract: An analyte detection device includes a shell, a sensor, a transmitter, a battery, a memory, and a processor. The sensor includes an internal part and an external part. The internal part is used to penetrate into a user's subcutaneous skin to obtain a first parameter value. At least one predetermined pair-data set composed of the first parameter value and a second parameter value is pre stored in the memory. The second parameter value is associated with the in vivo analyte parameter information. The processor is programmed to call predetermined pair-data set from the memory, and obtain the second parameter value based on the first parameter by indexed. The transmitter is used to transmit the first parameter value and/or the second parameter value to a remote equipment. The battery is used to provide electric energy.

Abstract: An analyte detection device includes an outer shell, a circuit board and a battery cavity. The battery cavity includes a cavity shell, a diaphragm, an electrolyte, an anode plate, a cathode plate and a conductive strip, an electrolyte isolation layer is also arranged inside the cavity shell, an upper cover shell of the cavity shell is integrated with the circuit board. The shape and size of the battery cavity can be optimized according to the miniaturization design requirements of the analyte detection device to improve user experience.

Abstract: Provided relates to a continuous blood glucose measurement device which is produced with an assembled body attachment unit inside an applicator so as to minimize a user's additional work of attaching the body attachment unit to the body, thereby enabling the body attachment unit to be attached to the body by simply activating the applicator, and which is provided with a wireless communication chip in a body attachment unit so as to enable communication with an external terminal, thereby enabling simple and convenient use, without additional work of connecting a separate transmitter, and easier maintenance; and is activated by the user after the body attachment unit is attached to the body so as to enable the operation start time to be adjusted to an appropriate time according to user's needs, and to enable the operation to start in a stabilized state so that blood glucose can be measured more accurately.

Abstract: The invention disclosed generally relates to sensors, systems and methods for the detection of an analyte in a complex sample.

Abstract: A device includes a bottom housing that includes a printed circuit board, a processor formed on the printed circuit board, a probe tip coupled to the processor, and a first wall. The first wall includes a front side surface, a backside surface, and an opening extending from the front side surface to the backside surface. The printed circuit board is coupled to the front side surface of the first wall. The printed circuit board includes a plurality of electrical contacts located on the back surface and coupled to the processor. The electrical contacts on the backside surface of the printed circuit board are visible through the opening formed in the first wall of the bottom housing. The electrical contacts are sealed from fluid penetration and can connect to the electrical contacts of a battery connected to the device.

Abstract: A photoplethysmographic device includes a photoplethysmographic monitor, a laser housing electronically coupled to the photoplethysmographic monitor, at least two diode lasers, which generate laser light, positioned within the laser housing, the photoplethysmographic monitor providing electronic control of the at least two diode lasers, a desiccant fully enclosed within the laser housing, the desiccant positioned within the laser housing such that the desiccant does not make physical contact with the at least two diode lasers and/or interfere with the laser light, and a sensor in communication with the photoplethysmographic monitor and adapted to output the laser light from the at least two diode lasers. The sensor includes a photodetector, and the photoplethysmographic monitor receives and processes photoplethysmographic data from the sensor.

Abstract: A wearable device is described. The wearable device includes a housing having a back cover, and an optical mask on first portions of the back cover. The back cover includes a set of windows, with a first subset of windows in the set of windows being defined by an absence of the optical mask on second portions of the back cover, and a second subset of windows in the set of windows being inset in a set of openings in the back cover. An optical barrier surrounds each window in the second subset of windows. A set of light emitters is configured to emit light through at least some of the windows in the set of windows. A set of light detectors is configured to receive light through at least some of the windows in the set of windows.

Abstract: A medical implant device can comprise a light source and a light sensor, and a housing configured to receive the light source and the light sensor. The housing can comprise a first wall portion configured to be positioned over an extraluminal surface of a coronary sinus, the first wall portion comprising a first surface oriented toward the extraluminal surface. A first light-transparent region of the first wall portion can be configured to allow passage therethrough of an emitted light signal from the light source into the coronary sinus, and a second light-transparent region of the first wall portion can be configured to allow passage therethrough of a reflected light signal from within the coronary sinus for detection by the light sensor.

Abstract: An assembly, in particular for use in a confocal laser scanning apparatus, comprising a light-sensitive detector (1) and a device (2) for focusing and/or geometrically constraining light onto a detection path (3), is disclosed in response to the problem of specifying an assembly having a detector, which assembly can generate images as quickly as possible at high light sensitivity, characterised in that a device (4) is provided in the detection path (3) and spectrally splits the light, wherein at least one optical component (5) is provided, which directs the spectrally split light onto a detection row (6) of the detector (1), the detection row (6) having fields (6i) onto each of which light of different wavelengths is incident.

Abstract: Embodiments herein relate to embodiments herein relate to packages for implantable chemical sensors with features to facilitate calibration of the sensors therein. In an embodiment, a chemical sensor system is included having a package and an implantable monitor device therein. The implantable monitor device can include an optical chemical sensor. A first aqueous solution including a solute can be disposed within the package. In some embodiments, the package includes a first chamber a second chamber separated by a frangible seal. A first aqueous solution can be disposed within the first chamber and a second aqueous solution can be disposed in the second chamber. Other embodiments are also included herein.

Abstract: A method of analysis using mass spectrometry or ion mobility spectrometry that includes producing ions from a sample in a proximity of the sample, transferring the produced ions from the sample to a distance with a flexible or re-configurable ion guide, the flexible or re-configurable ion guide being connected to RF voltages, and separating the produced ions with a mass to charge or mobility analyzer located at the distance to provide spectrometric results; and detecting the separated ions with at least one detector.

Abstract: A wearable device for non-invasive monitoring of the presence, amount, and/or concentration of an analyte in a sample from a user of the device is described. The analyte is selected to be indicative of or related to a physiological status of a user. Relevant physiological status include hypoglycemia, infection, respiratory infection, urinary infection, gastrointestinal infection, obesity, diabetes, type I diabetes and type II diabetes.

Abstract: Transdermally emitted gasses are detected by applying a dermal sampling strip to the skin of a biological subject, capturing the gasses in a vapor space in the dermal sampling strip, and analyzing for at least one such gas captured in the vapor space of the dermal sampling strip. Analysis is preferably performed using an electrocatalytic cell, which can be mounted on the dermal sampling strip and form a wall of the vapor space.

Abstract: Analyte monitoring device calibration is described. A calibration system generates calibration results for multiple analyte monitoring devices during a calibration evaluation process. To do so, the calibration system implements a calibration board that includes a single ground electrode shared by, but not physically connected to, the multiple analyte monitoring devices. An input voltage is applied to an analyte-sensing element of each of the multiple analyte monitoring devices. Analyte-sensing elements and the common ground electrode are placed into/in contact with a reference bath that includes a known concentration of an analyte to be measured. The input voltage causes each analyte-sensing element to generate an electrical current that is indicative of the reference bath analyte concentration.

Abstract: A sensor calibration method comprises: providing a lot of sensors which are tested before production to obtain the summary pair-data set Di, classifying and dividing the summary pair-data set to obtain the typical pair-data sets Dj, and storing them in the computer; during production, testing the small number of pair-data of sensors to be delivered, inputting the small number of pair-data into the computer, and obtaining the closest typical pair-data set to the small number of pair-data through calculation, the typical pair-data set can be used as the predetermined pair-data of the sensor to be delivered, and the preset predetermined calibration function is no longer required, which improves the calibration efficiency of the sensor, reduces the production time, and improves the reliability of the sensor.

Abstract: The invention discloses a sensor calibration method, during production, some sample sensors are taken out from a lot of sensors for testing, to obtain the sample pair-data composed of the first test parameter value and the second parameter value. After averaging the first test parameter value, the range value composed of the average first test parameter value of the sample or the average value of the average first test parameter value of adjacent samples is given as the first parameter value of the lot, to obtain the predetermined pair-data set of the lot, and the preset predetermined calibration function is no longer required, which improves the calibration efficiency of sensors, reduces the production time, and improves the reliability of sensors.

Abstract: The invention discloses a sensor calibration method. A lot of sensors are tested before production to obtain the summary pair-data set, classify and divide the summary pair-data set to obtain the typical pair-data sets, and store them in the computer. During production, test small number of pair-data of sensors to be delivered, input the small number of pair-data into the computer, and obtain the closest typical pair-data set to the small number of pair-data and difference between them through calculation, and then adjust the closest typical pair-data set based on the difference, and the adjusted typical data set can be used as the predetermined pair-data of the sensor to be delivered, and the preset predetermined calibration function is no longer needed, which improves the calibration efficiency of the sensor, reduces the production time, and reduces the difference between the actual sensitivity of the sensor and the predetermined pair-data.

Abstract: A booty for an infant that heats the heel of the infant while preventing potential bruising, infection or cartilage damage caused by frequent heel sticks from blood tests being taken at the heel of the infant. The booty has a flexible body with a closure opening to allow the booty to be placed on the foot of the infant. The booty also has a closure device to adjust the size of the closure opening and further secure the booty to the foot of the infant. A warming device is included to heat the heel of the infant. The booty includes an attachment device to securely attach the warming device to the booty.

Abstract: A catheter assembly includes: a tubular catheter shaft; and an inner needle inserted into a lumen of the catheter shaft, the inner needle including an insertion distal end surrounded by a catheter distal end which is a distal end of the catheter shaft in an initial state of the catheter assembly in which the inner needle is inserted into the lumen of the catheter shaft. A wavelength conversion member is included in at least one of the catheter distal end or the insertion distal end, the wavelength conversion member including a wavelength conversion material that converts near-infrared light into visible light.

Abstract: A lancing device having a housing with a proximal end, a distal end and a longitudinal axis. The lancing device also has a lancet carrier translationally supported with respect to the housing. The lancet carrier has a proximal end and a distal end. The lancing device additionally has a charging mechanism and/or an ejection mechanism adapted to pivot into the lancing device for engaging portions of the lancet carrier to perform the same.

Abstract: A device for screening for autism spectrum disorder includes a housing configured for portable use, one or more cameras mounted to the housing, and one or more light sources mounted to the housing. The device captures a video of one or more eyes using the one or more cameras, emits a light stimulus using the one or more light sources, and synchronizes the video to the light stimulus. The device analyzes the video for measuring a pupillary response to the light stimulus. The device compares the pupillary response to one or more metrics. The device generates an output based on comparing the pupillary response to the one or more metrics, the output including a recommendation related to autism spectrum disorder.

Abstract: A method includes observing a call taker to produce first data, determining a first stress level of the call taker, at least in part based on the first data, determining if the first stress level exceeds a first predetermined threshold, determining an output action, if the first stress level exceeds the first predetermined threshold, and notifying of the action.

Abstract: A response profile evaluation device of the present invention can quantitively evaluate a response profile occurring in rating value data. A response profile evaluation device of the present invention, using a response tendency of a user as a response profile, and using a statistical distribution expressing the response profile of the user as a response profile distribution, includes: a receiving unit for receiving rating value data of the user; a response profile distribution estimating unit for estimating, based on the rating value data, response profile distribution candidates that are candidates of the response profile distribution, by using a candidate response profile distribution template including a type of the statistical distribution; and a response profile distribution evaluating unit for selecting the response profile distribution that is fitted to expression of the response profile of the user from the estimated response profile distribution candidates by using the rating value data.

Abstract: A diagnostic hub located in a toilet receives a wireless signal from a mobile device of a user and determines that the user is proximate to the toilet based on the wireless signal. An identification of the user is determined based on the wireless signal. A geolocation of the diagnostic hub is determined. Sensor data generated by biometric sensors and environmental sensors is received. The diagnostic intakes a mixture of water and urine from the toilet into an intake chamber of the diagnostic hub through an inlet line or one or more openings in a housing of the diagnostic hub. A lab-on-a-chip of the diagnostic hub executes a biochemical assay on a fluid volume of the mixture using a reagent. Substance levels present in the urine are determined based on the biochemical assay. Results based on the substance levels are determined, indicating a diagnosis of one or more diseases.

Abstract: A method, and a system to perform the method, of assessing brain injuries in real time, the method including placing an EEG cap on a subject's head at a first location, processing diagnostic data including brain wave data using a first communication device at the first location, transmitting the diagnostic data to a second communication device located at a remote second location, and displaying the diagnostic data in real time on the second communication device.

Abstract: A vision transformer system and method generate a diagnosis from an electrocardiogram (ECG) of the patient. A patch generating module generates image patches of the ECG. A tokenization module generates numerical patch-based tokens corresponding to image patches. A transformer module generates a numerical classification token from the numerical patch-based tokens. A classification module generates and outputs a diagnosis message from the numerical classification token, wherein the diagnosis message is the patient diagnosis corresponding to the patient ECG and indicating a state of health of the heart of the patient. A masking module mask a preset portion of the plurality of patches, and the numerical classification token is generated from the plurality of numerical patch-based tokens, the unmasked patches, and the masked patches. The tokenization module receives ECG training data to be trained to generate the numerical classification token. The method implements the vision transformer system.

Abstract: A wearable device for detecting heart rhythm abnormalities, comprising: at least one pulse oximeter configured to measure optically a bloodstream so as to monitor peak-to-peak (P-P) pulse timings; one ECG sensor having two or more pairs of dry electrodes and configured to measure two or more voltage signals in relation to heart rhythm activity, each voltage signal being measured across one electrode pair; and a processor unit; wherein in response to an irregularity in P-P pulse timings, the processor unit is operable to: activate the ECG sensor by polling, periodically and sequentially, each of the two or more electrode pairs; determine an electrode pair for data recording; and record voltage signal data measured through the determined electrode pair.

Abstract: In one embodiment, a medical system includes a catheter to be inserted into a chamber of a heart, and including electrodes to capture electrical activity of tissue of the chamber over time, a display, and processing circuitry configured to compute a propagation of a cardiac activation wave over an anatomical map of the chamber from a start time in a cardiac cycle to an end time in the cardiac cycle responsively to the captured electrical activity, render to the display a sub-region of the anatomical map, select a time-bounded portion of the propagation of the cardiac activation wave commencing at a time after the start time responsively to when the propagation would commence to be rendered in the sub-region of the anatomical map, and render to the display the time-bound portion of the propagation of the cardiac activation wave on the sub-region of the anatomical map.

Abstract: A muscle relaxation monitoring device includes a stimulation output unit configured to stimulate a nerve via a stimulation electrode attached to a living body of a subject, a signal detection unit configured to detect, as an electrical signal, a physiological signal generated from a muscle in response to the stimulation to the nerve by the stimulation output unit, via a lead-out electrode attached to the living body, and a controller configured to cause the stimulation output unit to stimulate the nerve, and determine an abnormal installation cause of the lead-out electrode, based on the electrical signal detected by the signal detection unit.

Abstract: This invention is a method to predict the motor response of presumptive negotiators after simulated decision challenges through measurement of glutamate/GABA ratios in spectral MRI (MRS) of the negotiators. The sampled voxels of MRS include precentral gyrus speech (larynx) and writing (hand) areas and/or supplementary motor cortex. The glutamate/GABA ratio or excitation/inhibition (E/I) ratio is predicted to be U shaped where an elevated E/I ratio is predicted to be impulsive decision-making and lower E/I ratio is predicted to be indecisiveness. This method may aid in the screening of negotiators who may be best suited for resolution of impasse conflicts.

Abstract: A system for measuring a membrane potential is disclosed. The system comprises a photoacoustic probe including a laser and an ultrasound transducer. The laser is configured to emit a light signal at one or more wavelengths to a neuronal cell. The neuronal cell may comprise a voltage-sensitive protein configured to absorb the light signal in a voltage-dependent manner. The ultrasound transducer is configured to receive a photoacoustic signal from the voltage-sensitive protein in response to absorbing the light signal. The system further comprises a processor configured to receive the photoacoustic signal from the ultrasound transducer and calculate a membrane potential of the neuron based on the photoacoustic signal. Methods of measuring a membrane potential and biomaterials related to the voltage-sensitive protein are also disclosed herein.

Abstract: Allergy is one of the world's most common chronic conditions. The state of the art method for allergy testing is the skin prick test (SPT) where different allergens are introduced into the skin of the tested person. This method is at best semi-quantitative, a relatively low number of tests can be performed and patients might experience unpleasant reactions. This invention is a novel allergy test providing fast, accurate and quantitative monitoring of allergic reactions in the skin. As a novelty, microneedle-based electrochemical sensor arrays are used to introduce allergens in the skin and perform electrochemical detection of biomarkers released from activated mast cells in the interstitial fluid.

Abstract: This document describes systems and methods for managing glycemia in patients with diabetes mellitus by optimizing insulin delivery dosages and timing. For example, this document describes systems and methods that utilize a patient's gastric emptying rate and other parameters to determine the optimal insulin delivery dosages and timing for the patient.

Abstract: An epidermal microfluidic device includes a rigid substrate defining microfluidic features (e.g., portions of channels, valves within channels, and/or portions of reservoirs) with gradient variation in height thereof. A rigid substrate of such a devices may permit flexure during use without breakage and without distortion of microfluidic features therein, such as by providing channel-defining, reduced-width linking portions extending outward between a central portion and reservoir portions, with the reservoir portions lacking direct coupling therebetween. An epidermal interface layer comprising a flexible material and defining a first aperture may be adhered to skin of a user, and multiple microfluidic devices may be sequentially provided over, and removed from, the epidermal interface layer to collect multiple independent, pristine sweat samples during an extended active collection period.

Abstract: A computer-implemented method includes providing, by at least one computer processor, a plurality of signal channels, wherein the plurality of signal channels includes a plurality of electrical uterine monitoring signal channels and a plurality of acoustic uterine monitoring signal channels; determining, by the at least one computer processor, a plurality of channel weights, wherein each of the channel weights corresponds to a particular one of the signal channels; and generating, by the at least one computer processor, a combined uterine monitoring signal channel by calculating a weighted average of the signal channels based on the channel weight for each of the signal channels.

Abstract: An electronic device is provided.

Abstract: A plurality of optical excitation ultraviolet light wavelength bands is scanned on a wound sample. The material sample exhibits optical spectral characteristics along the light wavelength spectrum. Excitation response wavelengths emitted by the wound sample are captured in response to the plurality of optical excitation ultraviolet light wavelength bands. The capturing is accomplished using an image sensor. Output values of a plurality of pixels of an image from the image sensor are measured. The image represents excitation response wavelengths captured by the image sensor. The measuring detects optical spectral characteristics of the wound sample, and the optical spectral characteristics are in response to the plurality of optical excitation light wavelength bands. An output signature indicative of composition of a condition of the wound sample is provided, wherein the condition of the wound sample provides a metric of wound monitoring.

Abstract: The present disclosure provides methods for evaluating tissue damage and the use of spatial variation in Sub-Epidermal Moisture (SEM) values to determine damaged tissue for clinical intervention. The present disclosure provides methods of identifying deep and early-stage pressure-induced injuries or ulcers (PI/PU). The present disclosure provides algorithm for computing SEM delta values which inform clinical decision-making for developing intact skin PI/PUs including suspected deep tissue injury (sDTI) and Stage I PI/PUs.

Abstract: A health monitoring device, platform and related methods for assessing, tracking, analyzing, diagnosing and/or treating bruxism, sleep disorders and/or other dental health conditions or disorders. In some instances, a health monitoring device is provided in the form of a wearable mouthpiece having a plurality of sensors configured to track impact and/or force data over time associated with one or more bruxing events (e.g., teeth grinding and/or clenching), thereby allowing a healthcare professional to monitor the severity and frequency of grinding and/or clenching over time.

Abstract: Intelligibility analysis of a speech recording is provided. A first transcript for the speech recording is generated using a first automatic speech recognition (ASR) model. A second transcript for the speech recording is provided. The first transcript and the second transcript are compared. An intelligibility score is determined based on the comparing the first transcript and the second transcript.

Abstract: A multifunction device for improving sleep and methods of use are disclosed herein. The device can comprise an outer housing, a front panel, a front textile wrapped partially around the front panel, a plurality of LEDs within the outer housing, and an internal reflector coupled to the outer housing. The internal reflector can be configured to reflect light generated by the plurality of LEDs towards the front textile such that the light generated by the plurality of LEDs shines through the front panel and the front textile when a sleep-related program of the multifunction device is automatically initiated.

Abstract: A method for monitoring arterial pressure of a patient and detecting nociception of the patient includes receiving, by a hemodynamic monitor, sensed hemodynamic data representative of an arterial pressure waveform of the patient. A hardware processor of the hemodynamic monitor performs waveform analysis of the sensed hemodynamic data to calculate a plurality of signal measures of the sensed hemodynamic data. The hardware processor of the hemodynamic monitor calculates cross-correlational association measurements between each of the signal measures. The cross-correlational association measurements are outputted to a user interface. The cross-correlational association measurements are monitored for bursts in the cross-correlational association measurements. A nociception event of the patient is detected when a burst in one or more of the cross-correlational association measurements is outputted to the user interface.

Abstract: Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed.

Abstract: A medical implant includes an implant component configured to be implanted in a patient, an electrode array, an energy storage device, and a power management unit. The electrode array includes at least two electrodes spaced apart on the implant component. The energy storage device and power management unit are inside the implant component. The power management unit is operative to control electrical stimulation of the electrode array by current supplied by the energy storage device to be at a level which at least reduces formation of a biofilm on at least part of the implant component while implanted in the patient.

Abstract: A medical implant includes an implant component configured to be implanted in a patient, an electrode array, an energy storage device, and a power management unit. The electrode array includes at least two electrodes spaced apart on the implant component. The energy storage device and power management unit are inside the implant component. The power management unit is operative to control electrical stimulation of the electrode array by current supplied by the energy storage device to be at a level which at least reduces formation of a biofilm on at least part of the implant component while implanted in the patient.

Abstract: A hydration monitoring device and system is provided. The hydration monitoring device includes housing having a base with a receptacle for holding a water bottle, a weight sensor to detect changes in the water bottle's weight, and a transceiver for connectivity with an application on an electronic device. A display is disposed on an exterior of the housing and a speaker for delivering visual and audible notifications. The display is a touchscreen to provide a user interface for allowing the user to customize notifications and settings. The weight sensor tracks water consumption, and the system calculates a desired hydration rate based on user data and activity levels. The device and system provide each provide visual and auditory prompts to the user when water consumption falls below the target rate, ensuring adequate hydration. This system facilitates real-time monitoring and encourages consistent water intake, enhancing user health and well-being.