Abstract: A delivery device for use in administering a dry powder to a biological subject's airway is provided. The device comprises (a) a housing having an inlet in fluid communication with an outlet for delivering a flow of gas to the subject's airway; and (b) one or more cantilever structures located within the housing. Vibration of the one or more cantilever structures facilitates entry of the dry powder into the flow of gas, such that the dry powder can be delivered by the flow of gas through the outlet to the subject's airway. Also provided is a container for releasably storing a particulate composition, the container comprising a shell sealed by a seal in which the particulate composition is stored, wherein a puncturing device for rupturing the seal to release the particulate composition is housed within the shell. Further provided are associated methods for administering dry powder using the delivery device and/or container.

Abstract: A nebulizer as well as a container with a fluid for such a nebulizer are proposed. The container comprises a control device which indicates initially an unused state of the container before first use. An indicator device stops via a locking device further use of the container in a locked state when a predetermined number of uses has been reached or exceeded. After replacement of the container, the nebulizer can be reset and used again.

Abstract: Delivery of a dry powder via inhalation can be performed using an inhalation device having an inhalation tube and a hollow extension housing an assembly of components including a plurality of impellers, a puncturing device, and a dry powder container. The delivery of dry powder through the inhalation device is facilitated by the puncturing device puncturing the dry powder container, the impellers directing air flow, and the configuration of the extension and inhalation tube.

Abstract: The present disclosure generally relates to the field of nebulizers for aerosol generation and methods of using same for treating diseases and disorders.

Abstract: Methods, ovens, and associated apparatus. Ovens and methods are adapted for maintaining the quality of a pre-cooked food product. Rapid temperature and/or relative humidity restoration may be used. Ovens may include a partition movable to vary sizes of oven cavities. Ovens may include removable interior panels. Humidification mechanisms are adapted for generating water vapor which may be used to maintain the quality of a pre-cooked food product.

Abstract: Transnasal delivery of medication directly to a patient's brain is achieved using an iontophoresis wire cooperable with a medication administration device. A controller regulates an electric charge to the iontophoresis wire. The iontophoresis wire is insertable into each nasal cavity. This wire is preferably encased in a tube, through which the medication will be transnasally delivered. A cleaning solution may also be delivered to the nasal cavity after treatment to reduce irritation from the iontophoresis.

Abstract: Devices and systems are described for treating intraluminal locations such as in a patient's lung. The device has an elongated shaft with an inner lumen, preferably defined by an inner tubular member, formed of heat resistant polymeric materials such as polyimide. The device also has an outer surface formed of heat resistant material. High temperature vapor is directed through the inner lumen into the intraluminal location to treat tissue at and distal to the location. An enlarged or enlargeable member, such as a balloon, is provided on a distal portion of the shaft to prevent proximal flow of the high temperature vapor upon discharge from the device.

Abstract: An administration method for a medical spray inhaler and the medical spray inhaler, which utilizes an inhaling sensing unit to sense an air flow change for generating an inhaling signal after a user inhales by an inhaler body. A control unit is then used to receive the inhaling signal and calculate a delay time. After the delay time, the control unit outputs a control instruction to control a medicine container disposed on the inhaler body to spray a medical spray and concurrently records the ventilation volume per inhalation of the user.

Abstract: An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject.

Abstract: A pulsating inhaler comprising: (a) a fluid oscillator providing focused fluid columns with a series of alternating high and low pressure zones and (b) at least one outlet orifice adapted for delivering said focused fluid column to the respiratory tract of said patient. The fluid oscillator further comprises a piston which is actuated by a motor with an eccentric mechanism. According to alternative embodiment of the invention, the fluid oscillator comprises a rotating disc having a missing section.

Abstract: A nebulizer which has an insertable container and a counter device for counting operations of the nebulizer, and is opened for replacing the container. A securing device having locking portions which are forced apart is provided to prevent reconnection of an already used container. The nebulizer has an indicator for showing the current container number and/or symbols indicating the need container replacement. The indicator is driven by the force of an internal spring. The indicator member also controls a lock of the container for locking the container against further actuation. The lock is reset after container replacement.

Abstract: An inhaler is disclosed. It comprises a housing to receive a strip having a surface and a plurality of blister pockets depending from said surface. Each blister pocket contains a dose of medicament for inhalation by a user. The inhaler has a blister strip drive mechanism including a blister strip drive member shaped to contact the strip along a line defined by the crease between a blister pocket and said surface, to drive said strip.

Abstract: The invention relates to a turbo-inhaler, comprising an active-liquid container (1) holding a liquid having an active ingredient dissolved therein, a nebulizer (2), by means of which liquid can be converted into an aerosol and introduced into a blade housing (3), in which a bounding dome (4) is suspended, the concave side (41) of which is directed at the nebulizer, an exhaust air duct (5), which is connected to the blade housing in the area of the convex side (42) of the bounding dome, and a supply-air guide (6), by means of which supply air can be introduced between the blade housing and the active ingredient, wherein at least one guide blade (7) is placed on the convex side of the bounding dome and spirally extends thereon.

Abstract: An atomizer and a method of dispensing and atomizing fluid into individual containers through a nozzle are proposed, where in order to improve the dosing accuracy, a preliminary amount of fluid, flushing the nozzle, is dispensed before each dose is dispensed.

Abstract: A dispensing device and a storage device for dispensing a formulation as a spray. The storage device has multiple separate and pre-metered doses of the formulation in receptacles or cavities. In order to allow a very compact arrangement, the receptacles or cavities are arranged in a first group and a second group axially offset, and preferably, forming a double ring arrangement, and the storage device is rotatable and axially moveable for dispensing the doses one after the other.

Abstract: A portable, handheld breath-actuated inhaler comprises a generally cylindrical body that comprises body portions 1, 3 that receive a canister 2 of pressured fluid such a nicotine to be inhaled in an aerosol by a user, a mouthpiece 7 in the first body portion 1 configured to deliver an amount of the aerosol to the mouth of the user from the canister. A trigger is cocked ready for releasing pressurized fluid from the canister by manually sliding the body portions 1, 3 towards one another. The trigger comprises a compression spring 26 and a cam 33 which engages a pressure sensitive puff lever 28 with a plate 29 that releases the cocked trigger when a user sucks on the mouthpiece and draws in air through air inlet opening 26. Release of the trigger releases spring 26 which slides the body portions apart and also opens a valve in the canister so as to deliver the aerosol to the mouthpiece.

Abstract: An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject.

Abstract: A fluid dispenser device including a body (10); a reservoir (20) containing fluid; a dispenser member (30), such as a pump or a valve, for dispensing the fluid contained in the reservoir (20) through a dispenser orifice (45); and a cap (50) that is adapted to cover said dispenser orifice (45) in a closed position. The cap (50) is pivotally mounted on the body (10) to turn about an axis (A) between the closed position and an actuation position, the cap (50) including an actuator mechanism (55; 56, 57) adapted to actuate the dispenser member (30) directly, while the cap (50) is turning towards its actuation position.

Abstract: Dispensing apparatus for delivering metered doses of product from a pressurized dispensing container, having a housing for receiving, in use, the pressurized dispensing container, and an outlet through which, in use, metered doses of product from the pressurized dispensing container can be dispensed. The housing has an aperture via which the pressurized dispensing container can be inserted into the housing. The dispensing apparatus is at least partially enclosed by a shrink wrapped film, the shrink wrapped film including an opening which is: (a) at least partly aligned with the aperture of the housing; and (b) dimensioned so as to allow, in use, said pressurized dispensing container to pass through the opening in order to be inserted into the housing via the aperture.

Abstract: An atomizer for a fluid, in particular, a fluid for medical aerosol therapy. In order to allow simplified operation and improved safety in use, the atomizer has a counter device for counting the number of operations of the atomizer and the number of containers inserted. The atomizer is locked against further operation and/or against removal of the current container or insertion of a new container, if a certain number of operations of the atomizer and/or a certain number of containers inserted has/have been reached or exceeded.

Abstract: The present invention provides a dispensing apparatus for delivering metered doses of product from a pressurised dispensing container comprising: a housing comprising a body portion and a removable mouthpiece, the body portion containing a dose counting mechanism and a sleeve; the body portion comprising an aperture through which said pressurised dispensing container can pass to be received in the sleeve but through which the sleeve is unable to pass such that the sleeve is retained within the body portion; the sleeve being located in the body portion such that an upper end of said pressurised dispensing container when received in the sleeve is accessible to allow actuation of said pressurised dispensing container; the apparatus comprising means for retaining said pressurised dispensing container in the body portion.

Abstract: A nebulizer and a method of breathing using the nebulizer is described. The nebulizer and breathing techniques are capable of delivering medicament into the sinus cavity of a user.

Abstract: A dispenser includes a dispenser housing, an indicating device connected to the dispenser housing and a container removably engaged with the dispenser housing. The container and the dispenser housing remain connected as the container is moved between an engaged position and a disengaged position relative to the dispenser housing. The dispenser housing includes an upper portion pivotally connected to a lower portion.

Abstract: A microdosing device with a dosing chamber for the at least temporary reception of a liquid quantity, and with which is associated at least one discharge opening is provided. A vibrating unit in operative connection with at least one boundary surface of the dosing chamber is provided in order to vibrate the same for a discharge process, and with a delivery function unit connected to the vibrating unit for activating the latter during a delivery time period. A drying function unit is additionally provided and can be activated in time-separated manner with respect to the delivery function unit in order to free the dosing chamber from liquid residues.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a delivery unit comprising a substance supply unit and a nozzle unit including at least one nozzle fluidly connected to the substance supply unit for generating an aerosol spray for delivery to a nasal airway of the subject; and an aerosol interactor operable to interact with an aerosol spray as generated by the at least one nozzle.

Abstract: An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject.

Abstract: A nebulizer and a method of breathing using the nebulizer is described. The nebulizer and breathing techniques are capable of delivering medicament into the sinus cavity of a user.

Abstract: An inhaler (1) for producing an inhalable aerosol of powdered medicament is disclosed. The inhaler (1) comprises an aerosolising device having a cyclone chamber (45) of substantially circular cross-section, inlet (24) and outlet (25) ports at opposite ends of the chamber (45) for the flow of drug laden air through the chamber (45) between said ports (24, 25) and, a bypass air inlet (46) for the flow of clean air into the chamber (45). The bypass air inlets (46) are configured so that air entering the chamber (45) through said inlet (46) forms a cyclone in the chamber (45) that interacts with the drug laden air flowing between the inlet (24) and outlet (25) ports. The inhaler (1) may have a tapered drug laden air flow conduit (70) to accelerate the flow prior to entry into the chamber (45) and/or an impaction element (81, 84, 92, 105) to deagglomerate drug particles.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab radially moveable between a first radial position, in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position and then allow it to return to the first radial position. The pusher or the casing further includes at least one stop between the pusher and casing to delineate the end of a first stroke corresponding to a first dose of medicament, and the beginning of a second stroke corresponding to a second dose of medicament.

Abstract: An atomizer for a fluid, in particular, a fluid for medical aerosol therapy. In order to allow simplified operation and improved safety in use, the atomizer has a counter device for counting the number of operations of the atomizer and the number of containers inserted. The atomizer is locked against further operation and/or against removal of the current container or insertion of a new container, if a certain number of operations of the atomizer and/or a certain number of containers inserted has/have been reached or exceeded.

Abstract: A powder inhaler for administering powder by inhalation, comprising: a flow path defined by a plurality of surfaces through which a stream of air is in use drawn on inhalation by a user; and dosing means (18) for providing a dose of powder to the flow path for entrainment in the stream of air; characterized in that the inhaler further comprises dislodging means for dislodging powder accumulated on a surface of the flow path downstream of the dosing means (18).

Abstract: An atomizer for a fluid, in particular, a fluid for medical aerosol therapy. In order to allow simplified operation and improved safety in use, the atomizer has a counter device for counting the number of operations of the atomizer and the number of containers inserted. The atomizer is locked against further operation and/or against removal of the current container or insertion of a new container, if a certain number of operations of the atomizer and/or a certain number of containers inserted has/have been reached or exceeded.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab radially moveable between a first radial position, in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position and then allow it to return to the first radial position. The pusher or the casing further includes at least one stop between the pusher and casing to delineate the end of a first stroke corresponding to a first dose of medicament, and the beginning of a second stroke corresponding to a second dose of medicament.

Abstract: An inhalant dispenser has a cover 3 pivotally carried on a body 6. The cover has a cam arrangement for lifting a junction member 41 against the action of the spring in an inhalant can C. Lifting of the junction member cocks a breath actuated dose release mechanism. The latter includes a flap 61 in the breath path. The flap is carried on the junction member and is arranged to release a hinged member 48 by action of latches 70 on the flap and sears on the hinged member.

Abstract: A spray or injection device that includes a casing or a pusher that includes at least one tab configured to move radially between a first radial position in which the tab does not impede the movement of the pusher with respect to the casing, and a second radial position in which the tab opposes movement of the pusher. The tab includes an opening. The pusher or the casing, respectively, includes at least one ramp-shaped projection configured to bring the tab into the second radial position then to penetrate the opening thereby allowing the tab to return to the first radial position. The pusher or the casing, respectively, further includes at least one stop region against which the tab abuts when the tab is brought into the second radial position by the projection. The stop region occurring just before the projection being opposite the opening.

Abstract: Apparatus and methods are provided for delivery of a medicament to a respiratory system. A reservoir is provided for a liquid medicament with the reservoir having a liquid medicament inlet port and a medicament outlet. An aerosol generator is provided at the medicament outlet of the reservoir for aerosolizing the liquid medicament. A connector entrains the aerosolized medicament from the aerosol generator with a gas.

Abstract: An apparatus for use in conjunction with a metered dose inhaler which includes a novel valve system to aid in the delivery of aerosolized medicament to a subject. The apparatus also includes a novel rotational flow generator to aid in the useable delivery of said medication and avoid its loss either in the apparatus or by non-useful delivery to said subject.

Abstract: An apparatus and method for the self-administration of a plurality of doses of an intranasal liquid pharmaceutical composition, including opioid analgesics, that includes a drug delivery device containing a plurality of sealed vials, each vial containing a predetermined volume of the pharmaceutical composition, a pump assembly for conveying the liquid pharmaceutical composition from the interior of the vial and discharging it as a nasal spray in response to manual activation by the patient, and programmable means for sequentially advancing a vial to the ready position after passage of a prescribed time interval following the last activation of the delivery device.

Abstract: A drug delivery device for delivering to a patient a drug composition from a container which contains the drug composition where the container is adapted to be placed in a dispensing mode thereof on application of an actuating condition thereto is disclosed. The device includes a dispensing unit adapted to receive the container, the dispensing unit having an actuating mechanism operable to apply the actuating condition to the container and an outlet through which the drug composition is dispensable from the device, and a removable casing unit for the dispensing unit. The dispensing and casing units have securing features for releasably, fixedly securing the units together, and the dispensing unit is operable to apply the actuating condition to the container when fixedly secured to the casing unit and when independent from the casing unit.

Abstract: A rotatably actuated counter is disclosed. The counter includes a ratchet driven unit wheel nested within a tens wheel. Each wheel has a radial face displaying counting indicia. The tens wheel is transparent, allowing the indicia on the unit wheel to be viewed adjacent to the indicia on the tens wheel to provide a total count. A slave wheel is positioned between the unit and tens wheels. A gear on one face of the slave wheel engages gear teeth on the tens wheel. A Geneva mechanism on the other face is engaged by a foot on the unit wheel once per rotation. The wheels are rotatably mounted within a housing having a sidewall with a window through which the count indicia may be viewed. The unit wheel rotates in ten increments and then rotates the tens wheel through one increment by engaging and rotating the slave wheel.

Abstract: Dosology of thyroid hormone using a suitable device

Abstract: According to the present invention there is provided an inhalation device for dispensing medicament comprising a body (150), the body being shaped for receipt of a medicament carrier (286); and an actuator (10) having a mouthpiece (20), the actuator being reversibly movable between a dispensing position and a storage position; wherein the body includes an air channel (253), and the actuator includes an air hole (225) such that the air channel communicates with the air hole when the actuator is in the dispensing position and the air channel and air hole do not communicate when the actuator is in the storage position.

Abstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

Abstract: An apparatus and method for the self-administration of a plurality of doses of an intranasal liquid pharmaceutical composition, including opioid analgesics, that includes a drug delivery device containing a plurality of sealed vials, each vial containing a predetermined volume of the pharmaceutical composition, a pump assembly for conveying the liquid pharmaceutical composition from the interior of the vial and discharging it as a nasal spray in response to manual activation by the patient, and programmable means for sequentially advancing a vial to the ready position after passage of a prescribed time interval following the last activation of the delivery device.

Abstract: An inhaler is instantly activated upon its removal from a cover or cover unit, and by rotating a cartridge component of the inhaler with respect to a mouthpiece portion, so as to create a flow pathway for ambient air and particles. The cartridge component includes a chamber, whose contents typically include dry powders or the like. Upon creation of the flow pathway, the contents of the chamber are instantly accessible for immediate inhalation by a user through the mouthpiece portion.

Abstract: A portable, handheld breath actuated inhalator, to aerosolize and distribute a pressurised liquid, including a breath flow path defined between an air inlet (132) and a mouthpiece (131) outlet, a container (30) for the liquid, an aerosolizing element (115) for introducing the aerosolized liquid into the breath flow path, a valve element (113) between the container and the aerosolizing means for allowing fluid communication between the container and the aerosolizing element, and an actuator to regulate the valve element. The actuator is mechanical and is energized by the flow of inhaled air.

Abstract: A nebulizer has a main body and an inhalator attachment which is detachably attached to the main body. The attachment has a tubular member including an receptacle. The tubular member has a medicament inlet for receiving nebulized medicament from the nebulizer, an inhalation opening which is opposite the medicament inlet and through which a patent inhales the nebulized medicament passed through the tubular member, and an air inlet through which air outside is introduced and passed through the tubular member. A brim member for guiding droplets of liquefied medicament and the user's saliva into the receptacle is formed partially around the medicament inlet. The air inlet is preferably formed by cutting the tubular member at the medicament inlet.

Abstract: An apparatus (1) for nebulising a liquid, in particular for medical use, comprises a box case (2) and a compressor assembly (4) housed internally to the box case (2) and provided with an air intake conduit (5) and an air delivery conduit (6). A device (10) for activating the compressor assembly (4) is housed internally to the box case (2) and is provided with an external command (16) which can be activated by the user. A nebulising bulb (17) is housed in the box case (2), presents a terminal mouthpiece (18) and is provided with an air inlet section placed directly in communication with the delivery conduit (6) of the compressor assembly (4).

Abstract: There is provided an inhalation device suitable for dispensing medicament, particularly medicament for use in the treatment of respiratory disorders. The device comprises a body; a medicament carrier, locatable within said body; a mouthpiece, reversibly movable from a storage position wherein said mouthpiece is within the body to an in-use position wherein a portion of the mouthpiece protrudes from the body and wherein the mouthpiece is in communication with the medicament carrier to allow passage of medicament therebetween; and a mouthpiece actuator, rotatable relative to the body, and coupled to the mouthpiece such a first rotation of said mouthpiece actuator moves the mouthpiece towards said storage position and an opposing rotation of the mouthpiece actuator moves the mouthpiece towards said in-use position. The translational path definable by the movement of the mouthpiece from the storage to the in-use position does not bisect the rotational path defined by the rotation of the mouthpiece actuator.

Abstract: A metering device suitable for use in a dry powder inhaler comprises a housing defining a reservoir. The reservoir contains a powder. A rotatable auger, having a first and second end, has one or more flutes extending between the ends. The first end of the auger communicates with the reservoir. A dosing member, defining a dosing recess having a desired volume, is positionable adjacent said second end of said auger. Rotation of said auger causes the powder to be transferred through the flutes and into the dosing recess to fill the recess volume with a specific dose of powder.