Abstract: A delivery device, e.g. an inhaler, comprises a rotatable metering member adapted to dispense a measured amount of material, a material delivery passage and a material delivery orifice and at least one actuator member adapted to move the metering member from a material retaining position to a material dispensing position. In a magazine comprising a plurality of metering members, the actuator and metering members may operate in a radial direction. A plurality of rotatable magazines may be utilized in the delivery device. The delivery device may be used to deliver a single or a combination therapy.

Abstract: A nasal delivery device for and a method of delivering at least one substance to a nasal cavity of a subject. The nasal delivery device and method includes a delivery unit comprising: a nosepiece for fitting to a nostril of a subject; a mouthpiece through which the subject in use exhales; a breath analyzer for analyzing the concentration of at least one component in exhaled air from an exhalation breath; and a substance supply unit for supply at least one substance, the substance supply unit including a control unit for controlling the same to control supply of at least one substance in response to the detected concentration.

Abstract: An inhaler includes an accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a pressure relief system that manages pressure within a medicament reservoir of the inhaler to ensure consistently dispensed doses, and a dose counting system indicating the number of doses remaining in the inhaler.

Abstract: The present invention includes dry powder inhalers for dispensing and/or holding inhalant formulated dry powder substances and associated fabrication and dispensing methods that can employ an amplitude modulated non-linear signal comprising a plurality of superimposed frequencies, the frequencies corresponding to a priori flow characteristic frequencies of the dry powder being dispensed. The present invention also includes pocket-sized inhalers with an elastomeric flexible pivoting cover.

Abstract: An aerosol generation device comprising an oscillatable membrane (1) for the nebulization of a liquid, having a first curved region (11), and an oscillation generating device (2, 3) by which the membrane can be caused to oscillate such that a liquid disposed on one side of the membrane is nebulized through the oscillating membrane and is present on the other side of the membrane as an aerosol. The membrane has at least a second region (12) which is surrounded by the first region (11). The first region (11) and the second region (12) have different curvatures (1/r1, 1/r2).

Abstract: A powder inhalator comprising: a housing; a supply member for holding a powdered drug for a large number of doses and having a drug discharge aperture at its bottom surface; a drug carrier, to which the powdered drug is supplied from the drug discharge aperture of the supply member, and having on its upper surface a measuring recess that has a volume equivalent to one dose of the drug; and an operation member disposed so as to move freely back and forth, and operate the drug carrier; the drug carrier moving in contact with the bottom surface of the supply member to carry the powdered drug loaded into the measuring recess from the position of the drug discharge aperture to an air inhalation channel, wherein the drug carrier is disposed slidably so that the measuring recess moves in a circular manner by sliding the drug carrier.

Abstract: Dry powder blister packages include sealed blisters with a piezoelectric active layer that flexes to vibrate the dry powder in a blister to facilitate active dispersion.

Abstract: In a device to deliver a powdery medicine into a nasal cavity, one-way valve 33 is built in an air flow passage 31 of a capsule housing/holding part 30, the one-way valve 33 is controlled for the opening pressure by a spring 34 and opens by a pressure of air from the pump 50, the one-way valve end 71 does not interfere the setting/detaching operation of the capsule setting/detaching part 40 and the capsule K when the one-way valve 33 is opened and intrudes as far as the inside of the capsule to disperse the medicine in the capsule K when the one-way valve 33 is opened by pressing of the pump 50 upon dosing thereby capable of reliably dosing at a adequate dose also including the medicine falling as far as the one-way valve 33 to the nasal cavity of the user.

Abstract: A fluid dispenser device comprising a fluid reservoir (10), and a dispensing member (20), such as a metering valve, fitted to said reservoir (10), said reservoir (10) and said valve (20) being assembled into a body (30) incorporating a dispensing orifice (31), said device being characterized in that it includes an adjustment element (40) disposed between the reservoir (10) and the body (30), said adjustment element (40) being provided with adapter means (45) that are movable and/or deformable and that co-operate with the body (30) and/or with the reservoir (10) while the reservoir (10) is being assembled into the body (30), thereby compensating for the manufacturing tolerances of said body (30) and/or of said reservoir and/or said dispensing member (20).

Abstract: A medicament container (10) is disclosed which comprises at least two compartments (21, 22). Each of the compartments (21, 22) is adapted to contain a dose of a medicament in powdered form and is provided with at least one opening (23) through which, in use, the medicament can be dispensed. The container (10) is preferably cylindrical in form, the diameter of the cylinder being greater than its depth such that the container (10) has the form of a squat drum.

Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.

Abstract: A powder delivery device for the delivery into a patient's nasal cavity of a physiologically active agent in powdered form. A closure restricts the unwanted ingress of moisture into the device when the device is not in use. The action of opening or closing this closure may be linked to charging an air reservoir with air and/or moving a fresh powder-containing receptacle into communication with a powder delivery passage.

Abstract: A medicine cartridge including a medicine accommodating body having a plurality of medicine accommodating sections formed side by side with each other in a peripheral direction of the medicine accommodating body. Each medicine accommodating section accommodates therein medicine in powder form. A section defining an inflow hole is formed at the inner peripheral side of the medicine accommodating body to supply air into the medicine accommodating section. A section defining an outflow hole is formed at the outer peripheral side of the medicine accommodating body to flow out the medicine introduced by air.

Abstract: To improve administration of powdered pharmaceuticals, a pharmaceutical powder cartridge (1) for powder inhalers for holding a pharmaceutical depot for a large number of pharmaceutical powder doses is proposed, having at least one storage space (6) and an integrated metering device, said integrated metering device comprising at least one metering slide (9, 13, 14) which can be moved approximately transversely in a metering slide channel (12) at least from a filling position to an emptying position, approximately transversely with respect to the direction of flow of the pharmaceutical powder out from the at least one storage space (6), said metering slide channel (12) with the at least one metering slide (9, 13, 14) being sealed off from the environment at least in the filling position of the metering slide (9, 13, 14), and also further measures and a corresponding inhaler.

Abstract: A medicament package comprises a medicament container (10) and a holder (20) within which the medicament container (10) is closely received. The holder (20) comprises a support (25) of a rigid material. The support (25) has an opening, to the periphery of which an enclosure (21) is bonded. The medicament container (10) is closely received within the enclosure (21) such that the material of the enclosure (21) seals openings formed in the container (10). The container (10) can be dispensed from the package into a delivery device by pressure applied to the enclosure (21).

Abstract: A delivery device, e.g. an inhaler, comprises a rotatable metering member adapted to dispense a measured amount of material, a material delivery passage and a material delivery orifice and at least one actuator member adapted to move the metering member form a material retaining position to a material dispensing position. In a magazine comprising a plurality of metering members, the actuator and metering members may operate in a radial direction. A plurality of rotatable magazines may be utilized in the delivery device. The delivery device may be used to deliver a single or a combination therapy.

Abstract: There is described a medicament delivery device which comprises a medicament reservoir, a medicament delivery passage and a metering member adapted to transfer a measured dose of medicament from the medicament reservoir to the delivery passage characterized in that the device is provided with a moisture proof barrier. The medicament delivery device is especially suited for use as an inhaler. There is therefore also described an inhaler which provides improved airflow for the dispersion of medicament, and a method of treating patients suffering from a respiratory disorder.

Abstract: An apparatus (1) for the nasal or oral delivery of a medicament, comprises: (a) a sealed flexible container (3) containing the medicament and a gaseous propellant for the medicament; and (b) a delivery device (5), comprising: (i) a main body part (5a) which, at least in use, holds the sealed flexible container (3); and (ii) a compressive part (5b) which, when actuated in use, causes the sealed flexible container (3) to be ruptured and the propellant to expel the medicament from the container, thereby delivering the medicament.

Abstract: A powder inhaler includes a container for storing powdered medicament. A metering member has a dosing recess and is moveable between a filling position in which the dosing recess is in alignment with an opening of the container, and an inhalation position in which it is in alignment with an inhalation channel. A mouthpiece is in communication with the inhalation channel for enabling inhalation of the dose of powdered medicament when in the inhalation position. A protective member provided between the metering member and the inhalation channel is moveable between a closed position in which the protective member covers the dosing recess, thereby preventing powdered medicament contained in the dosing recess from entering the inhalation channel, and an open position in which the protective member does not cover the dosing recess, thereby exposing the dosing recess to the inhalation channel for enabling inhalation of the dose of the powdered medicament.

Abstract: An inhaler for dispensing medicament in the form of a dry powder is powder is provided with an airway (50) through which a dose travels from an ejection zone to an outlet of the airway. The airway (50) has an inlet means which is so arranged as to create a jacket of air, flowing through a part of the airway extending from the ejection zone to the outlet. The jacket of air surrounds said dose and thereby prevents it form impinging on the airway walls. This reduces accumulation of material on the airway walls, and thus improves the consistency of performance of the inhaler. Preferably, the inlet means includes a throat for producing a stream of fast flowing air which creates a zone of low pressure in front of the ejection zone, thereby to facilitate ejection of a dose.

Abstract: A device for delivering a powdered medicament by inhalation comprises an air inlet passage having low pressure-drop and low turbulence for stabilizing air flow before aerosolization, a dosing cup in the region of reduced air velocity to delay aerosolization, a high pressure drop throat to generate a high velocity flow, a rapidly expanding diverging passage to create a free jet of air with high turbulence and an outlet passage having large cross-sectional area to control the rate of dissipation of the free jet. The device is simple yet capable of consistently providing uniform and effective powder aerosolization and deagglomeration over a variety of patient inhalation profiles.

Abstract: An inhaler device comprising a container for powdered medicament, an inhalation channel, a movable metering member, a depressible actuator and a multiple dosage preventing means for locking the depressible actuator after use such that the actuator is unlocked only upon inhalation. The inhaler device is useful in the treatment of respiratory diseases such as asthma. The multiple dosage preventing means of the device eliminates the risk of unintentional overdosing.

Abstract: A blister pack unit for a powder inhaler, comprising a body which includes a plurality of surfaces which each includes a plurality of blisters (21, 22) containing powder containing medicament and are rotationally symmetrically disposed about an imaginary axis.

Abstract: A device and an arrangement are disclosed, which create a powder Air-razor, which into an inhalation air volume de-aggregates and disperses a finely divided medication powder. The powder is generally loaded onto a dosing member intended for use with an inhaler. By sucking air through a mouthpiece connected to a nozzle, particles of the load of powder are gradually de-aggregated, dispersed and continuously released into the sucked air during a defined interval. The gradual de-aggregation and dispersal of the medication powder is generated by a relative motion introduced between the nozzle and the dosing member. The powder is generally loaded onto a larger area than the area of the air nozzle inlet. The nozzle may be positioned outside the dose area until an air stream has begun to flow into the nozzle by suction of air in an inhaling operation.

Abstract: A pneumatic nebulizer for the delivery of medications that produces aerosol mist in a downward direction. A gas inlet introduces a high velocity gas that passes through a venturi orifice producing a venture effect. A liquid stored in a reservoir is drawn into the orifice, atomizing forming droplets. The droplets are further atomized by hitting a baffle. The mist formed substantially circumscribes the baffle.

Abstract: A method based on an Air-razor tool is disclosed thereby providing de-aggregation and dispersal into air of a dose of finely divided medication powder. In sucking air through a nozzle, particles of a powder dose made available to the nozzle, are gradually de-aggregated and dispersed into a stream of air entering the nozzle. The gradual de-aggregation or dispersal is produced by a relative motion introduced between the nozzle and the dose. In a preferred embodiment, the powder is deposited onto a substrate, occupying a larger area than the area of the nozzle inlet. The nozzle is preferably positioned outside the powder area, not accessing the powder in its relative motion until a created air stream entering the nozzle, exceeds a threshold flow velocity.

Abstract: The invention relates to a multidose powder inhaler for the dispensing of a powdered medicament by inhalation. The device comprises two or more medicament containers for different drug powders which are inhaled as a combined medication, and separate aerosolization channels for each drug powder. The device of the invention is useful, for example, in the treatment of asthma.

Abstract: The invention relates to a multidose powder inhaler for the dispensing of a powdered medicament by inhalation. The device comprises two or more medicament containers for different drug powders which are inhaled as a combined medication. The device of the invention is useful, for example, in the treatment of asthma.

Abstract: The invention pertains to a dry powder inhaler (1) with a mouthpiece (2) for dispersing pharmaceutical drug formulations, which has available an auxiliary energy source in the form of a pressure medium system (3), with a device for provisioning (6) of a powder formulation (7), whereby upon activation of the pressure medium system a gaseous pressure medium (8) released by the pressure medium system (3) forms with the powder formulation (7) an aerosol (9) in such a way that the powder particles are present in dispersed form within the gaseous pressure medium (8).

Abstract: An inhaler disc cartridge comprises a carrier disc with radially outwardly extending resilient fingers, each with a medicament powder dosage. A sealing disc and an indexing ring are bonded to the disc. A cam sequentially and manually deflects a selected finger causing it to snap against an anvil to release the dosage by momentum energy transfer. In other embodiments, a cassette includes a carrier substrate reel of deposited powder dosages with a dosage sealing tape. The substrate comprises a belt with a plurality of transversely extending triangular fingers, each finger tip with a dosage thereon. Each finger is snapped in sequence against an anvil while a clamp secures the belt as the fingers are deflected. The spring fingers are corrugated in one embodiment cooperating with an anvil having channels and a device for inducing agglomeration breakup air streams through the channels.

Abstract: An inhaler for delivery of a dry powder medicament is disclosed that includes a breath sensor for sensing the breath of a patient, a reservoir for the dry powder, a meter for metering an amount of dry powder from the reservoir, and electro-mechanical coupling means for actuating said meter, wherein said coupling means is directly or indirectly responsive to said breath sensor.

Abstract: A multiple-dose powder inhaler is disclosed comprising an inhaler body defining a medicamnent container, an air channel, a mouthpiece, a rotatable metering drum with one or more peripheral dosing recesses and a dose counter for indicating the number of metered doses of medicament that have been dispensed from, or remain in, the medicament container. The inhaler is useful e.g. in the treatment of asthma.

Abstract: A method based on an Air-razor tool is disclosed thereby providing de-aggregation and dispersal into air of a dose of finely divided medication powder. In sucking air through a nozzle, particles of a powder dose made available to the nozzle, are gradually de-aggregated and dispersed into a stream of air entering the nozzle. The gradual de-aggregation or dispersal is produced by a relative motion introduced between the nozzle and the dose. In a preferred embodiment, the powder is deposited onto a substrate, occupying a larger area than the area of the nozzle inlet. The nozzle is preferably positioned outside the powder area, not accessing the powder in its relative motion until a created air stream entering the nozzle, exceeds a threshold flow velocity.

Abstract: A device and an arrangement are disclosed, which create a powder Air-razor, which into an inhalation air volume de-aggregates and disperses a finely divided medication powder. The powder is generally loaded onto a dosing member intended for use with an inhaler. By sucking air through a mouthpiece connected to a nozzle, particles of the load of powder are gradually de-aggregated, dispersed and continuously released into the sucked air during a defined interval. The gradual de-aggregation and dispersal of the medication powder is generated by a relative motion introduced between the nozzle and the dosing member. The powder is generally loaded onto a larger area than the area of the air nozzle inlet. The nozzle may be positioned outside the dose area until an air stream has begun to flow into the nozzle by suction of air in an inhaling operation.

Abstract: An inhalation device for administering a powdered medicament by inhalation including a suction tube through which the medicament is drawn on inhalation by a user, a blister pack, a housing which carries the blister pack and has housing surfaces, the suction tube being removably connected to the housing and having a distal end which can interact with the blister pack and a proximal end through which the user inhales, and a resilient member that resiliently biases the suction tube into a position where it is spaced from the housing surfaces to facilitate grasping of the suction tube by the user when the inhalation device is ready for use.

Abstract: The problem of the invention is to so develop known dispensers, that it is possible to very precisely determine the actual discharged medium volume.

Abstract: The present invention discloses an inhalation device for dispensing a medicament. The device includes a housing defining a lumen, and level indicator and dose indicator devices both of which are operably associated with the housing. The level indicator device linearly indicates a remaining amount of medicament, while the dose indicator device indicates a number of doses dispensed for a predetermined time period.

Abstract: An arrangement for supplying a medical apparatus with anesthetic is so improved that, when changing the anesthetic supply vessel (1), the new anesthetic is made available directly and, when there is a malfunction of an anesthetic metering device (2), an exchange is possible in a simple manner. The arrangement includes a supply vessel (1) for the liquid anesthetic (6), a metering device (2) for liquid anesthetic and a pin-and-socket connection (15) between the metering component (2) and a vessel receptacle (3) of a medical apparatus (4). The metering component (2) is electrically drivable and is connected to the supply vessel (1) so as to form a modular unit.

Abstract: For discharging a medium, such as a powder, a film/foil seal (16) of a reservoir chamber (24) is pierced by a tool (40) in a first axial movement, after which the medium is suctioned via an orifice (9) in feeding a delivery flow via passageways (55) from the chamber (24). On completion of a return stroke and twisting the tool (40) relative to the reservoir body (6) a further chamber (24) may be emptied in the same way, thus enabling e.g. a pharmaceutical active substance to be administered in two individual doses as expedient for nasal treatment.

Abstract: An inhalation-activated inhalator having a primary inhalation passage and a secondary inhalation passage disposed in communication with the primary inhalation passage and a source of medicament. The primary inhalation passage has airflow inhibiting mechanism connected to a blocking plate positioned to selectively block fluid flow in the secondary inhalation passage. As the user's inhalation reaches a defined rate, the flow inhibiting mechanism restricts flow through the primary inhalation passage and moves the blocking plate to enable airflow through the secondary passage. Thus, as the user achieves a desired inhalation rate, the medicament is provided through the secondary inhalation passage, thereby optimizing the delivery of medicament to the lungs.

Abstract: A device intended for the dispensing of a powdered medication by inhalation. The device includes a powder container (1), and air channel (2), and a metering strip (4) equipped with a dosing recess (3). The metering strip (4) can be moved along a flat surface (5) from a filling position, in which the dosing recess (3) is filled with powder coming from the container (1), to an inhalation position, in which the dosing recess (3) is in the air channel (2).

Abstract: An inhaler device for administration of a dry powder to a patient includes a package containing a dose of the dry powder and a magnetic field generator, which produces a magnetic field in a vicinity of the package. The magnetic field causes motion of particles of the powder so as to deaggregate the powder in the package, whereby the powder is inhaled by the patient. Preferably, the package includes walls made of a flexible material, which vibrate under the influence of the magnetic field so as to impart the motion to the particles.

Abstract: Inhalation device comprising a body (55) defining a reservoir (56) for medicament in the form of a powder, an outlet (57) through which a user can inhale, and a dosing member (53) with at least one metering recess formed therein. The dosing member (53) is moveable between a first position in which the at least one metering recess communicates with the reservoir (56) to receive a dose of powder therefrom and a second position in which the at least one metering recess communicates with the outlet (57) to permit the user to inhale the dose. The at least one metering recess is formed in a face of the dosing member which is urged into contact against a similar mating face of the body at the lower end of the reservoir to form a dynamic seal. At least one of the faces (51) is made of a flexible material having a hardness of less than 80 Shore A.

Abstract: An inhalant medicator comprises a medicator body having a granular medicine accommodation chamber and an inhalant port, and air passageways disposed in the medicator body and communicating the inhalant port via the granular medicine accommodation chamber to the atmosphere for supplying granular medicines into the inhalant port. Also provided is a granular medicine diffusion means located downstream of the granular medicine accommodation chamber for efficiently diffusing the granular medicines. A cylindrical adapter 10 is detachably installed in the inhalant port 9.

Abstract: A medicament carrier (10) having a first and a second spaced apart screen (12, 14) each of which has surfaces (12B, 14B) defining a plurality of interstices (12A, 14A). The carrier (10) contains powdered agglomerated medicament particles (SM) loaded onto the first screen surface (12B) such that the interstices (12A) of the first screen (12) are at least partially open and free of the agglomerated medicament particles (SM). When an air stream is provided to the carrier to entrain the agglomerated powdered medicament particles (SM) and move them from the first screen (12) through the interstices (14A) of the second screen (14), the agglomerated powdered medicament particles (SM) are sheared by air flow gradients created by the first and second screens (12, 14) and by contact with the surface (14B) of the second screen (14) to create particles of respirable particle size range. The carrier (10) can be used in a dry powder inhalator device.