Means For Mixing Treating Agent With Respiratory Gas Patents (Class 128/203.12)
  • Patent number: 10806888
    Abstract: A respiratory assistance device (1) for a patient, includes a tubular element forming a main channel (5) (207) which is to be connected via the distal end (7) thereof to an airway of the patient, the main channel connecting to the exterior of the respiratory system of the patient via the proximal end (6) thereof, the device further including at least one auxiliary channel (8) (209) allowing the injection of jets of breathable gas for ventilation of the patient via the distal outlet openings (17) of the auxiliary channel(s), the outlet openings opening out into the main channel in the vicinity of the distal end thereof, deflection elements (14b) (14a) allowing the deflection of gas jets to the interior of the main channel, and an internal jet separator, coaxial and central to the main channel, which further ensures diversion of the flow for expired gases.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: October 20, 2020
    Assignees: VYGON
    Inventors: Georges Boussignac, Jean-Luc Carrez, Elodie Bertheuil, Laurent Lesimple Bobert, Cyril Riga
  • Patent number: 10806501
    Abstract: This invention relates to the treatment of a patient's lung, for example, a lung exhibiting chronic obstructive pulmonary disease (COPD) and in particular to methods and devices for affecting lung volume reduction, preferably for achieving acute or immediate lung volume reduction following treatment. The lung volume reduction is effected by delivering a condensable vapor at a temperature above body temperature to the desired regions of the patient's lung to damage tissue therein. Blood flow and air flow to the damaged tissue region is essentially terminated, rendering the target region non-functional. Alternative energy sources may be used to effect the thermal damage to the lung tissue.
    Type: Grant
    Filed: April 30, 2017
    Date of Patent: October 20, 2020
    Assignee: Uptake Medical Technology Inc.
    Inventors: Robert L. Barry, Brian Cran, Dean T. Corcoran, Sheldon K. Lee
  • Patent number: 10780239
    Abstract: A system for controlling patient sedation and spontaneous breathing intensity includes a ventilator system that delivers ventilation to the patient. The system further includes a spontaneous breathing control module configured to determine a first spontaneous breathing intensity at a first sedative status of the patient, and a second spontaneous breathing intensity at a second sedative status of the patient. A sedation/breathing relationship is then defined between spontaneous breathing intensity and sedative status for the patient based on the first and second sedative statuses and the first and second spontaneous breathing intensities. The spontaneous breathing control module then receives a desired spontaneous breathing intensity for the patient and determines a desired sedative status that achieves that desired spontaneous breathing intensity based on the sedation/breathing relationship.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: September 22, 2020
    Assignee: General Electric Company
    Inventors: Mika Olli Kristian Sarkela, Erkki Heinonen
  • Patent number: 10765818
    Abstract: A dry powder inhaler with a blister folding device can include a housing to receive a single blister containing a dose of medicament for inhalation by a user, and a mouthpiece through which a dose of medicament is inhaled by a user and a blister opening device. The blister opening device can include a blister support element for supporting a blister containing a dose of medicament for inhalation by a user, and a blister folding element co-operable with the blister support element. The blister folding element and the blister support element can be movable relative to each other between a first position, for insertion of the blister into or onto the blister support element, and a second, burst, position in which the blister folding element has co-operated with the blister support element.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: September 8, 2020
    Assignee: Vectura Delivery Devices Limited
    Inventors: Roger Clarke, Peter Wilson
  • Patent number: 10744283
    Abstract: A tidal dry powder inhaler comprising: a miniature pressure sensor, a sensor port of said sensor being pneumatically coupled to a flow channel through which a user can inhale; a processor configured to process data received from a sensing element of the sensor to make a determination that inhalation of a spontaneous breath through said flow channel is in progress; a controller configured to, responsive to said determination, issue a start dosing signal; and a dosing mechanism configured to release dry powder medicament into the flow channel during inhalation of said spontaneous breath in response to receiving said signal.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: August 18, 2020
    Assignee: MicroDose Therapeutx, Inc.
    Inventors: Mark Steven Morrison, Douglas E. Weitzel
  • Patent number: 10737051
    Abstract: A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N2O4, activate upon operator demand, convert N2O4 to NO2 via a heating element(s) controlled by a console to deliver NO2 at a controlled flow rate, direct concentrated NO2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: August 11, 2020
    Inventors: Barry N. Gellman, Eddie Tajudeen, Lucas Gamero, Joshua Hopkins, Edward E. A. Bromberg, Ryan Denton, Bryan J. Johnson, David Fine
  • Patent number: 10729185
    Abstract: An aerosol delivery device is provided that includes a user interface including a pushbutton and a display. A control component contained coupled to the user interface controls operation of at least one functional element of the aerosol delivery device. The control component controls the display to present a menu including a plurality of menu items selectable using only the pushbutton. Each menu item of the plurality of menu items is associated with a respective functional element of the aerosol delivery device, and the control component is configured to navigate the plurality of menu items, and select a currently-presented menu item of the plurality of menu items for control of the respective functional element, in response to respective first and second types of presses of the pushbutton, the first and second types of presses being of different durations.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: August 4, 2020
    Assignee: RAI STRATEGIC HOLDINGS, INC.
    Inventors: Raymond Charles Henry, Jr., Glen Joseph Kimsey, Frederic Philippe Ampolini, James William Rogers
  • Patent number: 10722664
    Abstract: A hand operable inhalator for dispensing a powdery substance, in particular a pharmaceutical substance, with a supply chamber, a discharge channel and a dosing chamber, wherein the discharge channel protrudes into the supply chamber, and the dosing chamber and discharge channel can be moved relative to each other. In order to indicate an inhalator for dispensing a powdery substance that makes the dosing chamber advantageously fillable, the discharge channel can be rotated around a rotational axis, and that the dosing chamber can be filled while the discharge channel rotates. The inhalator can have a dosing chamber that can be moved from a closed into an open state and vice versa. The inhalator can have a discharge channel that incorporates a turbulence means, which has a helically running wall and is to carry a flow while discharging air provided with the substance.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: July 28, 2020
    Inventor: Alfred Von Schuckmann
  • Patent number: 10695512
    Abstract: An inhaler includes a main body having a canister housing, a medicament canister retained in a central outlet port of the canister housing, and a dose counter having an actuation member for operation by movement of the medicament canister. The canister housing has an inner wall, and a first inner wall canister support formation extending inwardly from a main surface of the inner wall. The canister housing has a longitudinal axis X which passes through the center of the central outlet port. The first inner wall canister support formation, the actuation member, and the central outlet port lie in a common plane coincident with the longitudinal axis X such that the first inner wall canister support formation protects against unwanted actuation of the dose counter by reducing rocking of the medicament canister relative to the main body of the inhaler.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: June 30, 2020
    Assignees: Ivax Pharmaceuticals Ireland, Norton (Waterford) Limited, Teva Pharmaceuticals Ireland
    Inventors: Declan Walsh, Derek Fenlon, Simon Kaar, Jan Geert Hazenberg, Daniel Buck, Paul Clancy, Robert Charles Uschold, Jeffrey A. Karg
  • Patent number: 10698426
    Abstract: Fluid control systems, including mass flow control systems, mass flow ratio control systems, and mass flow and ratio control systems, as well as corresponding methods for fluid control are provided. These systems allow one shared pressure sensor to be used for multiple flow channels, and a controller which can accurately determine mass flow on the basis of fluid pressure detected by this shared pressure sensor.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: June 30, 2020
    Assignee: MKS Instruments, Inc.
    Inventors: Junhua Ding, Michael L'Bassi, Wayne Cole
  • Patent number: 10688259
    Abstract: The present invention relates to an inhalation device (1), to the use thereof, and to a kit comprising the inhalation device. The inhalation device (1) has an air inlet (14), an air outlet (15) designed as a mouthpiece or nosepiece, and a recess (17) which is designed to receive a container (2) with an inhalable substance. An air duct (L) extends from the air inlet (14) through the recess (17) to the air outlet (15). Moreover, the inhalation device (1) has at least one hollow mandrel (16, 16?) which protrudes into the recess (17) and from which at least one air delivery line (14?, 14?) extends to the air inlet (14) or at least one air outlet line (15?) extends to the air outlet (15). The inhalation device (1) is characterized in that the inhalation device (1) has two limbs (11, 12), each with a work end (11?, 12?) and with an actuation end (11?, 12?), wherein the limbs (11, 12) are connected by means of a joint (13) which lies between the work ends (11?, 12?) and the actuation ends (11?, 12?).
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 23, 2020
    Inventor: Klaus-Dieter Beller
  • Patent number: 10688261
    Abstract: Systems and methods are described for monitoring usage of a medicament dispenser—particularly an inhaled medicament dispenser. While operating in a low-power mode, a first sensor is monitored for a signal indicative of handling of the medicament dispenser by a user. In response to detecting such handling, the device exits the low-power mode and begins to monitor a second sensor for a signal indicative of dispensing of the medicament. The usage monitoring device can be embodied as an attachment configured to be selectively coupled to one of a variety of different inhalers including, for example, a Diskus-type inhaler and a Respimat-type inhaler.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: June 23, 2020
    Assignee: Reciprocal Labs Corporation
    Inventors: John David Van Sickle, Greg Tracy, Mark Gehring, Eric Hoffman, Kevin Houlihan, Chris Hallberg
  • Patent number: 10688273
    Abstract: A dual pressure respiratory assistance device including a gas source which supplies a flow of gas into an air tube having a bubbler branch and a patient branch. A first tube that is connected to the bubbler branch is at least partially submerged in a fluid. An oscillatory relief valve cycles between first and second configurations. The relief valve includes an oscillating member which captures gas released through at least one hole in the first tube when the oscillating member is in a first position. The gas in the oscillating member causes the oscillating member to rise to a second position, wherein gas is released from the oscillating member and the at least one hole is blocked when the oscillating member reaches the second position.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: June 23, 2020
    Assignee: The Board of Trustees of Western Michigan University
    Inventors: Peter Allen Gustafson, Joseph David Hudson Taylor Barnett, Stephen Chiramukathu John, Hoa Tri Le
  • Patent number: 10675422
    Abstract: Systems and methods for delivering medicament to a subject use one or more sensors to generate signals that represent characteristics of the ultrasonic energy emitted into or by a respiratory medicament delivery device. Parameters based on these signals indicate energy amplitude in one or more frequency ranges. Such parameters can be used to determine respiratory parameters, patient adherence, and/or other parameters.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: June 9, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Mark Steven Morrison, Dirk Ernest Von Hollen
  • Patent number: 10668243
    Abstract: A system for pressurizing liquid is described herein. The system may include a liquid reservoir and a pump coupled to the liquid reservoir, the pump to draw liquid from the liquid reservoir. A compliant volume coupled to the pump receives liquid from pump. The compliant volume is composed of an elastic material to increase pressure of the liquid. A valve coupled to the compliant volume receives pressurized liquid from the compliant volume.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: June 2, 2020
    Assignee: General Electric Company
    Inventor: Douglas Kirk Bottom
  • Patent number: 10668223
    Abstract: A dose indicating mechanism for a drug delivery device for displaying of a dose of a medicament to be dispensed by the drug delivery device includes an elongated housing extending in an axial direction and having at least a first window and a second window that are spaced apart from each other in axial direction. The dose indicating mechanism further includes a dose indicating sleeve movably disposed in the housing and having at least one dose indication coinciding with the first window to display the size of a dose actually set, and an indicator operably engaged with the dose indicating sleeve and axially displaceable relative to the housing to coincide with the second window for indicating an operational status of the dose indicating mechanism.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: June 2, 2020
    Assignee: Sanofi
    Inventors: Stefan Bayer, Wolfgang Pelzer, Michael Pfoser, Björn Wilden, Philipp Zeitz
  • Patent number: 10661040
    Abstract: The present invention provides a wearable medical support for delivery of a treatment to the nose of a subject comprising: a nose mask formed from a heat moldable sheet of thermoplastic material, said nose mask comprises an aperture dimensioned to fit the nose of the subject, said aperture is flanked by two flaps whereby each flap is configured to be in contact with at least part of a lateral side of the nose; and a device configured to close fit said aperture, said device is provided at one end with an opening for receiving the nose and at the other end with at least one coupling suitable to be connected to one or more tubes for delivery of the treatment to the nose. The present invention further provides a sheet of heat moldable thermoplastic material for molding a mask directly on a subject's nose.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: May 26, 2020
    Inventor: Jean-Michel Anthony
  • Patent number: 10651866
    Abstract: Systems and methods are described to time delay a signal output from an analog-to-digital converter (ADC). The ADC includes a digital sensor responsive to an analog field quantity. The digital sensor is configured to output an oversampled digital output signal at a sampling clock frequency. A time delay element is configured to receive as an input, the oversampled digital output signal and to output a time delayed oversampled digital output signal. A filter is configured to receive as an input the delayed oversampled digital output signal. The filter low pass filters and decimates to a lower sample rate the delayed oversampled digital output signal. An output includes a low pass filtered decimated delayed digital output signal, where the lower sample rate is less than the sampling clock frequency.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: May 12, 2020
    Assignee: SOLOS TECHNOLOGY LIMITED
    Inventors: Dashen Fan, Joseph Yong Kwon
  • Patent number: 10617836
    Abstract: A respiratory device for supplying breathing air to a patient, including an oxygen inlet to be connected to an oxygen supply, and a compressed air inlet to be connected to a compressed air supply. The respiratory device also includes a turbine for sucking in ambient air. Switching between the individual operating modes can be done automatically or manually.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: April 14, 2020
    Inventor: Eugen Kagan
  • Patent number: 10596345
    Abstract: Systems, methods, and devices for humidifying a breathing gas using a vapor transfer unit are presented. The method includes providing a first vapor transfer unit having a gas passage and a liquid passage, delivering a liquid to the liquid passage, delivering a gas to the gas passage, humidifying the gas by delivering vapor from the liquid in the liquid passage to the gas in the gas passage, exiting the humidified gas outside the vapor transfer unit at first relative humidity and at a high gas flow rate, and reducing the gas flow rate through the first vapor transfer unit to less than a low gas flow rate, while preventing the relative humidity from exceeding the first relative humidity by more than an acceptable margin.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: March 24, 2020
    Assignee: VAPOTHERM, INC.
    Inventor: Scott A. Leonard
  • Patent number: 10576225
    Abstract: Therapy gas delivery systems that provide run-time-to-empty information to a user of the system and methods for administering therapeutic gas to a patient. The therapeutic gas delivery system may include a gas pressure sensor attachable to a therapeutic gas source that communicates therapeutic gas pressure data to a therapeutic gas delivery system controller, a gas temperature sensor positioned to measure gas temperature in the therapeutic gas source that communicates therapeutic gas temperature data to the therapeutic gas delivery system controller, at least one flow controller that communicates therapeutic gas flow rate data to the therapeutic gas delivery system controller, at least one flow sensor that communicates flow rate data to the therapeutic gas delivery system controller, and at least one display that communicates run-time-to-empty to a user of the therapeutic gas delivery system.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: March 3, 2020
    Assignee: Mallinckrodt Hospital Products IP Limited
    Inventors: Jaron M. Acker, Jeff Milsap, Robin Roehl, Jeffrey Schmidt, Craig R. Tolmie
  • Patent number: 10556075
    Abstract: A method for al of a volatile anesthetic agent from a breathing gas in a respirating apparatus includes the steps of leading at least a portion of the breathing gas through a portion of a line system in which the portion of the line system has a filter therein, cooling the breathing gas to a temperature below a temperature of the boiling point of the anesthetic agent when the breathing gas passes through the filter so as to condense the anesthetic agent out of the breathing gas, warming the breathing gas after the anesthetic agent is condensed, and leading the warmed breathing gas out of the portion of the line system back into the line system. The filter has activated carbon therein.
    Type: Grant
    Filed: October 6, 2010
    Date of Patent: February 11, 2020
    Assignee: LÖWENSTEIN MEDICAL TECHNOLOGY S.A
    Inventors: Pieter Borm, Bart Westerkamp
  • Patent number: 10549064
    Abstract: A heating apparatus includes a heating element which converts electrical power to heat energy, a heatable element having a first surface and a second surface, and a dielectric laminate layer between the heating element and the first surface of the heatable element, wherein the dielectric laminate layer is thermally conductive to transfer heat energy from the heating element to the heatable element, and wherein the second surface of the heatable element is configured heat a liquid in a container.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: February 4, 2020
    Assignee: ResMed PTY LTD
    Inventors: Zhuo Ran Tang, Ronald James Huby, Hargopal Verma, Andrew Roderick Bath, Roger Mervyn Lloyd Foote
  • Patent number: 10524509
    Abstract: An aerosol delivery device is provided. The aerosol delivery device comprises a control component and a digital pressure sensor. The digital pressure sensor is configured to measure a pressure imposed thereon, and generate a corresponding signal that indicates the pressure so measured. The he control component or the digital pressure sensor is further configured to control at least one functional element of the aerosol delivery device based on the pressure indicated by the corresponding signal, or a condition of the aerosol delivery device or a user thereof determined from the corresponding signal. Control of the at least one functional element includes output of the pressure or the condition for presentation by a display.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: January 7, 2020
    Assignee: RAI Strategic Holdings, Inc.
    Inventors: Rajesh Sur, Eric T. Hunt, Stephen B. Sears
  • Patent number: 10524508
    Abstract: An aerosol delivery device is provided that includes a substrate configured to carry an aerosol precursor composition, and a resonant transformer including a transmitter coupling device and a resonant receiver coupling device that is positioned in proximity to the substrate. The aerosol delivery device also includes a pulse width modulation (PWM) inverter configured to drive the resonant transformer. The PWM inverter includes a bridge circuit coupled to the transmitter coupling device, and a PWM controller embodied as an integrated circuit and configured to output a PWM signal to the bridge circuit configured to drive the transmitter coupling device to generate an oscillating magnetic field and induce an alternating voltage in the resonant receiver coupling device when exposed to the oscillating magnetic field. The alternating voltage causes the resonant receiver coupling device to generate heat and thereby vaporize components of the aerosol precursor composition.
    Type: Grant
    Filed: November 15, 2016
    Date of Patent: January 7, 2020
    Assignee: RAI Strategic Holdings, Inc.
    Inventors: Rajesh Sur, James W. Rogers, Stephen B. Sears, Eric T. Hunt
  • Patent number: 10518061
    Abstract: A humidifier for humidification of air to be delivered to a patient's airways may include a humidification chamber, a reservoir and a water delivery mechanism. The humidification chamber may include a water retention feature such as a wick that encloses part of the flow path, a heating element for heating the humidification chamber, and an air flow baffle configured to promote humidification. The humidifier may be further configured to execute one or more algorithms, for example to determine a condition of the wick or to detect condensation in the flow path. In some forms, the humidifier may also comprise algorithms for controlling one or more components of the humidifier such as to control the build up of foreign matter on the wick.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: December 31, 2019
    Assignee: ResMed Pty Ltd
    Inventors: Matthew Rolf Harrington, Dmitri Anatolievich Doudkine, Roger Mervyn Lloyd Foote, Ronald James Huby, Zhuo Ran Tang, Nan Hai Wu, Quangang Yang, Andrew Roderick Bath
  • Patent number: 10506828
    Abstract: A personal vaporizer having a pressure-induced liquid supply that allows a user to draw liquid from a liquid reservoir through applying a suction force on the mouthpiece. The amount of liquid drawn is proportional to the pressure induced, and proportional to the amount of vaporization a user may desire.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: December 17, 2019
    Assignee: WESTFIELD LIMITED (LTD.)
    Inventors: Wei Dai, Yongjie James Xu
  • Patent number: 10500355
    Abstract: The invention relates to a system composed of an inhaler and a capsule, preferably intended for single use. The capsule contains a preferably powdered pharmaceutical preparation which, for inhalation, is expelled from the capsule through at least one hole. The capsule comprises as capsule elements a capsule cap and a capsule body, at least one of which comprises at least one prefabricated hole. The prefabricated hole in the capsule is sealed off in the transporting state of the system and is open in the usage state. The hole is exposed by actuation of a pulling mechanism. Prior to this the hole is closed off by a capsule receptacle or a film. In one embodiment the capsule may be present in two different states, for example in different insertion positions of the capsule elements. In the first state the prefabricated hole is closed off and in the second it is exposed. Also shown is an inhaler suitable as a disposable product, which is manufactured from thermoformed parts or from blister film.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: December 10, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Holger Holakovsky, Jessica Frentzel-Beyme, Stephen Terence Dunne, Jens Besseler, Claudius Weiler
  • Patent number: 10493221
    Abstract: The invention relates to a powder inhaler and to a powder inhaler set that contains the powder inhaler. The powder inhaler comprises two half-shells (3, 4), which are connected to each other by means of at least one film hinge and are formed as a single piece. In a joined arrangement, the two half-shells (3, 4) enclose an air inlet region, a powder deposition region and powder release region, and an outlet region, through which regions a fluid path extends, wherein at least one of the half-shells (3, 4) has at least one air inlet opening (8) in the air inlet region. Furthermore, one of the half-shells (3, 4) has at least one powder-accommodating recess (9) in the powder deposition region and powder release region, while the outlet region has at least one deagglomeration structure (17, 17?) and an outlet for aerosol, which outlet is formed by the half-shells (3, 4).
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: December 3, 2019
    Inventor: Klaus-Dieter Beller
  • Patent number: 10495543
    Abstract: A vortex detection method is described. The method comprises storing a plurality of points at locations over a region (32) in which vortex detection is to be performed. A value for each of a plurality of fluid flow parameters, such as velocity, pressure and density, is determined at each point. The points are grouped as being contained in either a vortical flow portion or non-vortical flow portion of the region according to one or more statistical distribution for said fluid flow parameters. A point (p) in a vortex core is identified according to the direction of motion of an array of further points (46) relative to said point in the vortex core. The further points (46) may surround the vortex core point.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: December 3, 2019
    Assignee: ROLLS-ROYCE plc
    Inventors: Yiping Ke, Jian Cheng Wong, Chi-Keong Goh, Kee Khoon Lee
  • Patent number: 10456537
    Abstract: An apparatus includes a first member coupled to a second member. The first member defines a chamber containing a dry powder and includes a chamber wall that forms an outer boundary of the chamber. The second member includes a surface covering the chamber and defines an intake channel and an exit channel. The exit channel is fluidically coupled to the chamber via an exit opening. The intake channel is fluidically coupled to the chamber via an intake port. A center line of the intake channel is tangential to a portion of the chamber wall such that a portion of an inlet airflow conveyed into the chamber via the intake channel has a rotational motion. The intake port is defined at least in part by an intake ramp. The intake ramp includes a transition surface that forms an exit angle with respect to the surface of less than 105 degrees.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: October 29, 2019
    Assignee: CONCENTRX PHARMACEUTICALS, INC.
    Inventors: Eric C. Richardson, Gilbert S. Mott, Jr., William James Alexander
  • Patent number: 10449309
    Abstract: The invention relates to a powder inhaler and to a powder inhaler set that contains the powder inhaler. The powder inhaler comprises two half-shells (3, 4), which can be or are articulated to each other and which enclose an air inlet region, a powder deposition region and powder release region, and an outlet region in a joined arrangement, through which regions a fluid path extends. At least one of the half shells (3, 4) has at least one air inlet opening (8) in the air inlet region, and at least one air-swirling structure (5) is present in the air inlet region, which air-swirling structure defines the fluid path between the at least one air inlet opening (8) and the powder deposition and release region. Furthermore, one of the half-shells (3, 4) has at least one powder-accommodating recess (9) in the powder deposition region and powder release region, while the outlet region has at least one deagglomeration structure (17, 17?) and an outlet for aerosol, which outlet is formed by the half-shells (3, 4).
    Type: Grant
    Filed: January 20, 2015
    Date of Patent: October 22, 2019
    Inventor: Klaus-Dieter Beller
  • Patent number: 10451459
    Abstract: There is disclosed inhaler testing apparatus, in which at least one flow regulation valve, such as a needle valve, is located within a conduit. The flow regulation valve divides the conduit into inlet and outlet sides of the valve. The inlet side is arranged for connection to an inhaler and the outlet side for connection to a vacuum source. An electric motor provides variable adjustment of a flow opening through the valve. At least one sensor senses pressure or flow rate in the inlet side and a controller automatically adjusts the flow opening through the valve in response to readings from the at least one sensor. The apparatus may also comprise a shut off valve, such as a solenoid valve.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: October 22, 2019
    Inventors: Mark Andrew Copley, Benjamin Bradley, Ian Christopher Evans, Jonathan Charles Stephen Wright
  • Patent number: 10434276
    Abstract: A system for generating nitric oxide can include an apparatus positioned in a trachea of a mammal, the apparatus in eluding a respiration sensor for collecting information related to one or more triggering events associated with the trachea, an oxygen sensor for collecting information related to a concentration of oxygen in a gas, and one or more pairs of electrodes for initiating a series of electric arcs to generate nitric oxide, and the system for generating nitric oxide can also include a controller for determining one or more control parameters based on the information collected by the respiration sensor and the oxygen sensor, wherein the series of electric arcs is initiated based on the control parameters determined by the controller.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: October 8, 2019
    Assignee: The General Hospital Corporation
    Inventors: Warren M. Zapol, Binglan Yu, Paul Hardin, Matthew Hickcox
  • Patent number: 10422540
    Abstract: An evaporative cooling device may be provided. The device may comprise a plurality of rollers, a screen looped around the plurality of rollers, a motor coupled to at least one roller and configured to drive the at least one roller, a basin configured to hold a liquid within an interior of the basin, and wherein at least one roller is at least partially within the interior of the basin. The screen may travel into the basin and capture an amount of the liquid. As the liquid is drawn into an airstream feeding a heat rejection device, the liquid may evaporate, cooling the air. The cooled air may provide a more efficient heat rejection device.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: September 24, 2019
    Inventor: Matthew Morris
  • Patent number: 10398171
    Abstract: A device to adjust an amount of an active substance inhaled by a user includes two tanks. A first tank includes a liquid having a lower density of active substance than a liquid in the second tank. Each liquid is configured to evaporate when the liquid is heated beyond a predefined temperature limit. An inhaler to inhale the liquid vapor evaporating from each tank by the user. One heating resistor is associated with each tank. A controller to control the heating of each resistor to actuate each resistor independently in accordance with the determined amount of active substance to be vaporized. The ratio of the heating of the resistor of the second tank to the heating of the resistor of the first tank is an increasing function of the determined amount of active substance to be vaporized.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: September 3, 2019
    Assignee: ENOVAP
    Inventors: Alexandre Scheck, Philippe Lemail, Vincent Devos, Joseph Elkhoury, Murat Suna, Céline Kayal
  • Patent number: 10391268
    Abstract: A method of delivering a substance in aerosol or powder form to the upper respiratory tract is provided. The substance is orally administered into the larynx, through the pharynx, and out from the nose while minimizing inhalation into the lungs, whereby deposition of particles in the upper respiratory tract is achieved with limited deposition in the trachea, lower airways and lungs. Also provided is an oral delivery device having a mouthpiece for oral inhalation of a flow of a substance into the upper respiratory tract and a flow restrictor for enabling arrestment of the flow minimizing inhalation into the trachea, lower airways and lungs, which provides for a deposition of particles in the upper respiratory tract with limited deposition in the trachea, lower airways and lungs. Also provided is an oral delivery device having a mouthpiece for admission of a flow of a substance into the upper respiratory tract and a flow generator for pressuring the substance into travel through the upper respiratory tract.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: August 27, 2019
    Assignee: SERVICES MEDICAUX ARNOLD ET JOAN ZIDULKA INC.
    Inventor: Arnold Zidulka
  • Patent number: 10376662
    Abstract: The disclosure describes powder inhalers and dry powder inhaler storage cassettes that include a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance. The compartment is configured such that the preloaded doses are sealed within the compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system. The moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier. The sealing system is in sealing configuration prior to an advancement of the carrier, is relaxed upon an advancement of the carrier and is returned to its sealing configuration at the latest after release of the powder associated with the area of the carrier.
    Type: Grant
    Filed: September 26, 2016
    Date of Patent: August 13, 2019
    Assignee: Adamis Pharmaceuticals Corporation
    Inventors: Peter D. Hodson, Stephen W. Stein, Herbert C. Chiou, Zhaolin Wang, Thomas S. Robison, Michael K. Domroese, Blake D. Walburg
  • Patent number: 10369305
    Abstract: A medication dispenser includes a base seat, a circuitry unit and an outer casing. The base seat includes a mouthpiece. The circuitry unit includes a first circuit board, a battery, and first and second switches disposed on the first circuit board. The outer casing is movable relative to the base seat between a close position where the outer casing covers the mouthpiece and where the first switch is actuated such that electric power is prevented from being supplied from the battery to the first circuit board, and an open position where the outer casing uncovers the mouthpiece and where the second switch is actuated such that electric power is supplied from the battery to the first circuit board.
    Type: Grant
    Filed: October 2, 2017
    Date of Patent: August 6, 2019
    Assignee: Jabil Circuit (Shanghai) Ltd.
    Inventors: Ying Li, Ying-Zhen Tong, Yi-Nong Zhao, Fang-Long Xu, Yong-Feng Song, Conor Mulcahy, Xiao Qiang Fei
  • Patent number: 10342947
    Abstract: A tube system for ventilation with an outer tube (1) and with an inner tube (3) arranged non-centrally in the radial direction in the interior of the outer tube (1) is shown and described. The coaxial type tube system may be provided for ventilation and for medical applications. The flow resistance for the gas is minimized by the inner tube (3) being designed such that it is linearly in contact with an inner wall (35) of the outer tube (1).
    Type: Grant
    Filed: July 30, 2015
    Date of Patent: July 9, 2019
    Assignee: DRÄGERWERK AG & CO. KGAA
    Inventors: Stefan Kolk, Florian Dietz
  • Patent number: 10330495
    Abstract: A device for measuring rotational speed includes a housing comprising a base including vertical first and second end walls, and a cover including a window; a lower drive mechanism including a shaft including a gear adjacent to an inner surface of the first end wall, and gear elements rotatable around the shaft in a suspended manner, each gear element including first teeth and second teeth alternated with the first teeth; and an upper counter assembly including a reset shaft including a wing handle and a groove; a gear member rotatable around the reset shaft in a suspended manner and meshed with the gear, the gear member including a projection; and a first number wheel and second number wheels arranged from the gear member to the second end wall sequentially on the reset shaft. Each of the first and second number wheels is a ratchet type device.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: June 25, 2019
    Inventor: Ching-Feng Lee
  • Patent number: 10328221
    Abstract: An anesthetic breathing apparatus has a processing unit, a breathing circuit for providing an inspiratory patient gas mixture of re-breathed gas and/or fresh gas to a patient fluidly connected to the breathing circuit, and a fresh gas supply controllable by the processing unit for supplying a flow of the fresh gas to the breathing circuit in a composition including oxygen and at least one anesthetic agent (AA). A user interface includes a first user input element for receiving operator input for an anesthetic target value including an end expiratory concentration of the AA (EtAA) target value and/or an end expiratory minimum alveolar concentration (EtMAC) target value of an end expiratory MAC value of the patient, and a second user input element for receiving operator input for a desired control profile for the fresh gas supply for obtaining at least the anesthetic target value.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: June 25, 2019
    Assignee: Maquet Critical Care AB
    Inventors: Tom Pessala, Mari Andersson, Bengt Johansson, Stig Andersson, Mattias Rodehed
  • Patent number: 10307560
    Abstract: A positive airway pressure (PAP) device for supplying a flow of breathable gas to a patient includes a flow generator configured to pressurize a flow of breathable gas and a humidifier configured to receive and humidify the pressurized flow of breathable gas from the flow generator. The PAP device also includes a power source. The flow generator, humidifier and power source are positioned so that heat generated by at least one of the flow generator and the power source is conveyed to water in the humidifier.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: June 4, 2019
    Assignee: ResMed Limited
    Inventors: Dion Charles Chewe Martin, Barton John Kenyon, Alexander Virr, Dmitri Anatolievich Doudkine, Philip Rodney Kwok, Richard Charles Napper, John Michael Snow
  • Patent number: 10293126
    Abstract: The present disclosure pertains to a mechanical ventilator system configured to deliver a pressurized flow of breathable gas to the airway of a subject. The system is configured to generate the pressurized flow of breathable gas according to a volume control mode therapy regime that delivers a target tidal volume to the subject during inhalation. During an individual inhalation, the system is configured to determine and/or adjust an inspiratory pressure level of the pressurized flow of breathable gas of the volume control mode therapy regime. The inspiratory pressure level is adjusted such that during the inhalation the inspiratory pressure level is not reduced to impede respiratory effort by the subject responsive to the target tidal volume being exceeded during the inhalation. The system comprises one or more of a pressure generator, a subject interface, one or more sensors, one or more processors, a user interface, electronic storage, and/or other components.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: May 21, 2019
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Nathan John Berry Ann, William Anthony Truschel
  • Patent number: 10292687
    Abstract: Methods, apparatuses and systems are described for administering a swallowable cell collection device to a patient. Methods include releasing a swallowable bundle of string of the cell collection device from a bundling apparatus, maintaining the string in a swallowable bundle while releasing the swallowable bundle from the bundling apparatus, and placing the swallowable bundle on the tongue of the patient. Methods also include constraining a retrieval string of the cell collection device in a swallowable bundle with a dissolvable band and placing the swallowable bundle on the tongue of the patient.
    Type: Grant
    Filed: August 14, 2015
    Date of Patent: May 21, 2019
    Assignee: COVIDIEN LP
    Inventors: Mark A. Maguire, Alexander A. Lubinski, Jeevan Maddur Shankarsetty, Vijayaraghavan Srinivasan Chari, Neeraj Eswaradas, Yogesh Kishor Vikharankar, Narsing Sairaj Bheemarthi, Ananta Venkata Varaha Lakshmi Narasimha Srinivasa Murthy Aravalli, Inderjeet S. Bhalla
  • Patent number: 10274118
    Abstract: To provide a pipe joint for emergency releasing with a minimized seal structure to minimize leakage risk. Pipe joints (100, 101: pipe joints for emergency releasing) of the present invention include a cylindrical plug (10) in which a passage (1A: in-plug passage) is formed, a cylindrical socket (20) in which a passage (21A: in-socket passage) is formed, and shutoff valves (5, 24) mounted in the plug (10) and the socket (20) for opening the passages (1A, 21A) of the plug (10) and the socket (20) when the plug (10) is inserted into the socket (20) and shutting the passages (1A, 21A) of the plug (10) and the socket (20) when the plug (10) detached from the socket (20), wherein central axes of the passages (1A, 21A) of the plug (10) and the socket (20) do not form a straight line.
    Type: Grant
    Filed: December 5, 2017
    Date of Patent: April 30, 2019
    Assignee: Tatsuno Corporation
    Inventors: Masahiro Takezawa, Yuki Terasoma, Kiyoshi Kimura
  • Patent number: 10258751
    Abstract: A dry-powder inhalation device including a casing having at least one push button located on an external portion thereof, the push button including at least one pin structure, an air inlet located at a first terminus of the casing; a powder delivery port located at a second terminus of the casing and is positioned distal to the air inlet; and an elongated support panel located within an interior of the casing and being fitted within the casing so as to partially rotate therein about a single axis. The support panel has at least one compartment containing dry-powder located proximal to the first terminus, and the at least one pin structure is located proximal to the air inlet and arranged above the dry-powder compartment.
    Type: Grant
    Filed: October 20, 2014
    Date of Patent: April 16, 2019
    Assignee: Seroton, Inc.
    Inventors: David R. Elmaleh, Maxim D. Elmaleh
  • Patent number: 10245401
    Abstract: A subglottic suctioning system with a tracheal tube having a ventilation lumen, a cuff inflation lumen, and a suction lumen are disclosed which may help reduce the incidence of ventilator associated (or acquired) pneumonia. The suction lumen communicates with the space in the trachea above the cuff where secretions accumulate. The suction lumen has a valve on the proximal end for connection to a source of vacuum. The valve is adapted to interrupt the supply of vacuum to the suction lumen to allow for the introduction of a rinsing fluid in its place and to automatically re-establish the connection to the source of vacuum upon completion of rinsing. The rinsing fluid aids in maintaining an open suction lumen and may include medicaments and mucolytic agents to enhance or promote healing or to alter the properties of the mucus to make removal easier. The user may easily and repeatedly alternate suction and rinsing fluid through the suction lumen, i.e.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: April 2, 2019
    Assignee: Avent, Inc.
    Inventors: Brian J. Cuevas, Joseph A. Cesa, Scott M. Teixeira, Michael Sleva, Adrienne A. Hershey, Stephen A. Baratian
  • Patent number: 10226577
    Abstract: A drug delivery device is provided comprising a housing having an exterior surface, a drug-filled reservoir with an outlet, drug expelling means, and a flexible sheet. On the flexible sheet is formed or mounted input means adapted to be actuated corresponding to an event indicative of drug being expelled, a display adapted to display a time parameter, a processor, and an energy source. The processor is adapted to, based on input from the detection means, control the display to display a time parameter related to the time the event was detected, and the flexible sheet is attached at least in part to the outer surface of the housing.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: March 12, 2019
    Assignee: Novo Nordisk A/S
    Inventors: Bo Radmer, Andre Larsen, Mikkel Avlund, Morten Revsgaard Frederiksen
  • Patent number: 10220165
    Abstract: The invention relates to a capsule for receiving a preferably powdered pharmaceutical preparation and an inhaler in which, for inhalation, the preparation is expelled from the capsule through at least one hole. A capsule according to the invention comprises as capsule elements a capsule cap and a capsule body, at least one of which comprises at least one prefabricated hole. Systems according to the invention comprising inhalers and capsules are described, in which the prefabricated hole in the capsule is sealed off in the transporting state of the system and is open in the usage state. The hole is exposed by actuation of a pushing or pulling mechanism. Prior to this the hole is closed off by part of the capsule itself or by a capsule receptacle belonging to the inhaler. In one embodiment the capsule may be present in two different states, for example in different insertion positions of the capsule elements. In the first state the prefabricated hole is closed off and in the second it is exposed.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: March 5, 2019
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Stephen Terence Dunne, Jens Besseler, Jessica Frentzel-Beyme, Holger Holakovsky, Heinrich Kladders, Claudius Weiler, Ole Zumblick