Abstract: A nitric oxide administration device 1 includes a first flow path 101 including a first intake port 101a and an oxygen supply port 101b, an oxygen generation unit 100 which is arranged in the first flow path 101 and which generates concentrated oxygen from air introduced via the first intake port 101a, the generated concentrated oxygen being supplied via the oxygen supply port 101b, a second flow path 201 which is branched from the first flow path 101 and which includes an NO supply port 201b, and an NO generation unit 200 which is arranged in the second flow path 201 and which generates NO from gas distributed from the first flow path 101, the generated NO being supplied via the NO supply port 201b.

Abstract: Cartridges for vaporizer devices are provided. In one exemplary embodiment, the cartridge can include an atomizer and a channel extending through the cartridge from an inlet to an outlet. The atomizer includes a wicking element that is configured to substantially draw a vaporizable material from a reservoir and into the atomizer, and a heating element that is configured to substantially vaporize the vaporizable material into a vaporized material. The channel has an airflow path and a vapor path that intersect at a first junction between the inlet and the outlet. The airflow path is configured to receive and substantially allow air to pass therethrough, and the vapor path is configured to direct the vaporized material into the first junction so that the vaporized material mixes with the air to substantially form an aerosol downstream of the atomizer. Vaporizer devices are also provided.

Abstract: A heater and wick assembly for an aerosol generating system includes a capillary body, a heating element on an outer surface of the capillary body, and a pair of spaced apart electrical contacts fixed around the capillary body and coupled with the heating element. The heater and wick assembly also includes a support member extending along at least part of the length of the capillary body.

Abstract: An additive gas delivery apparatus for delivery of additive gas to inspirational gas can be set to deliver the additive gas according to a dosing setting in normal therapy, and can be set to deliver according to a backup dosing setting in response disruption of signals representing data for controlling the delivery of additive gas according to the dosing setting in normal therapy. An additive gas delivery apparatus has an inlet for the additive gas and an integrated inlet for gas for oxygenating the patient that are connected to a backup line to mix the additive gas and gas for oxygenating the patient to a set concentration of additive gas in the gas mixture at an integrated backup outlet of the additive gas delivery apparatus.

Abstract: A method for automatically controlling ventilation of a patient includes receiving a target expiratory CO2 concentration, measuring an actual expiratory CO2, and comparing the actual expiratory CO2 concentration to the target expiratory CO2. A ventilation rate for the patient is then calculated based on the comparison of the actual expiratory CO2 concentration and the target expiratory CO2 in order to maintain the actual expiratory CO2 within a predetermined range of the target expiratory CO2. The patient is then automatically ventilated based on the calculated ventilation rate.

Abstract: An aerosol delivery device is provided that includes a user interface including a pushbutton and a display. A control component contained coupled to the user interface controls operation of at least one functional element of the aerosol delivery device. The control component controls the display to present a menu including a plurality of menu items selectable using only the pushbutton. Each menu item of the plurality of menu items is associated with a respective functional element of the aerosol delivery device, and the control component is configured to navigate the plurality of menu items, and select a currently-presented menu item of the plurality of menu items for control of the respective functional element, in response to respective first and second types of presses of the pushbutton, the first and second types of presses being of different durations.

Abstract: Some embodiments of the invention relate to a system for delivering to a subject at least one pre-determined amount of THC, the system comprising: a memory which stores a scheduled regimen for delivery of THC to the subject, the scheduled regimen defining: a maximal amount of THC to be delivered, the amount being 0.75 mg THC or less, and a time period within which that amount is delivered, the time period being 2 hours or longer; a decision module which decides, according to the scheduled regimen, if a delivery should take place; and an inhaler device for delivering THC to the subject, the inhaler device comprising a controller which carries out delivery of THC based on the decision made by the decision module.

Abstract: A respiratory disease analytics system provides respiratory disease risk reports to a patient, provider, or third-party entity describing a patient's risk of experiencing a medication usage event given data in a geographic region. Regional data, including air pollutant conditions, weather conditions, demographic information, built environment factors, and regional health conditions for a geographic region are accessed from other sources and assigned based on event data recorded during a medicament usage event, as collected by sensors associated with the patient's medicament device/s. The regional data is assigned to medicament usage events occurring within a period of time. The assigned regional data is analyzed to determine an expected number of medication usage events for the geographic region occurring over the period of time.

Abstract: An ultrasonic electronic cigarette is disclosed. The electronic cigarette includes a housing (1) provided with an atomization sheet assembly (2) and a cartridge (3) therein. The atomization sheet assembly (2) comprises an ultrasonic atomization sheet (4) and an atomization seat (5) for supporting and fixing the ultrasonic atomization sheet (4). A top cover (7) is connected to the top end of the housing (1). A suction nozzle (8) is connected to the top cover (7). A press plate (9) and a locking mechanism (10) for controlling the press plate (9) to be opened or closed are also disposed in the housing (1). The cartridge (3) is fixed in the press plate (9). When the top cover (7) is closed and the locking mechanism (10) is locked, the press plate (9) and/or the cartridge (3) abut against the atomization sheet assembly (2).

Abstract: An electronic material sleeve has a length and wall thickness and is adapted to fit over a hand-held emergency medication dispensing device via material elasticity, the sleeve including at least a microprocessor and associated circuitry encapsulated within a wall of the electronic sleeve, the microprocessor adapted to support at least one computer aided task and at least one wireless communications technology, the sleeve having at least one encapsulated batter, a partly encapsulated charge port for charging the at least one battery, at least one LED partially encapsulated within a wall of the electronic sleeve, at least one audio speaker partially encapsulated within a wall of the electronic sleeve, and at least one eccentric rotating motor (ERM) adapted to vibrate encapsulated within a wall of the electronic sleeve, the sleeve capable of performing one or more tasks in response to a command signal.

Abstract: Extracorporeal membrane oxygenation systems and methods of use are disclosed. Several publications and patent documents are cited throughout the specification in order to describe the state of the art to which this invention pertains. Full citations of these references can be found throughout the specification. Each of these citations is incorporated herein by reference as though set forth in full.

Abstract: A humidification system has a humidification source and a main gases flow path. The main gases flow path has a low pressure region and a high pressure region. In some embodiments, each of the low pressure region and the high pressure region has an aperture. The pressure difference between the apertures promotes a gases flow between the main gases flow path and the humidification source, and results in humidifying the gases in the main gases flow path.

Abstract: A system for supporting the blood gas exchange by means of mechanical ventilation and extracorporeal blood gas exchange comprises a ventilation device for mechanical ventilation of the lungs of a patient, and an ECLS device for the extracorporeal blood gas exchange, wherein the ventilation system is designed to perform mechanical respiratory support by the ventilation device on the one hand and an extracorporeal blood gas exchange by the ECLS device on the other hand in coordinated, automated manner in order to support the gas exchange in the blood circulation of the patient, wherein the ECLS device sets a level of the extracorporeal blood gas exchange, and the ventilation device, on the basis of the level of the extracorporeal blood gas exchange set by the ECLS device, adjusts in automated manner to a level of the mechanical respiratory support.

Abstract: An inhaler for facilitating inhalation of dry powder includes a body defining an interior space and a mouth piece. At least one annular member is positioned within the interior space and is rotatable with respect to the mouth piece. The at least one annular member includes a plurality of compartments. Each compartment defines a cavity configured to hold dry powder. Each compartment includes at least one flap and an opening configured to release the dry powder when the at least one flap is reconfigured from a closed position to an open position. The at least one flap covers the opening and inhibits the dry powder from being released from the cavity in the closed position.

Abstract: Methods and systems are provided for anesthetic agent leakage diagnostics. In one embodiment, a method for diagnosing leaks in an anesthetic vaporizer includes calculating a leakage rate based on measurements of an anesthetic agent level in a sump of the anesthetic vaporizer, the measurements received from a fluid level sensor at a first time and a second time, and outputting a maintenance alert responsive to the leakage rate exceeding a threshold.

Abstract: An aerosol medicament delivery adapter comprises a first conduit, second conduit and a diverter element. The first conduit encloses a flow path chamber and extends between an upstream first end and a downstream second end. The second conduit comprises an aerosol medicament delivery conduit that includes an upstream first end adapted to be fluidly coupled to a particle generator, and a downstream second end luidly coupled to the first conduit at a Y-junction proximate the upstream first end of the first conduit. The diverter element comprises a flow diverter chamber disposed within the first conduit or the second conduit. The cylindrical flow diverter chamber includes a transitional flow cross-section and a principal axis, extending between a first end and a second end thereof. The diverter element creates flow eddies for enhancing an entrainment of aerosol particles, delivered via the second conduit, within a pressurized gas flow along the flow path within the first conduit.

Abstract: Devices, systems, and methods are disclosed which permit ventilation therapy concurrent with humidity and aerosol drug delivery. Exemplary mixer-heaters employ alternating actuation of humidity and drug nebulizers and may use a single constant power setting for the heating section while keeping a controlled outlet temperature over the course of treatment.

Abstract: An apparatus for humidifying a flow of breathable gas includes a water reservoir and a water reservoir dock forming a cavity structured and arranged to receive the water reservoir in an operative position. The water reservoir comprises a reservoir base including a cavity structured to hold a volume of water, the reservoir base including a main body and a thermally conductive portion provided to the main body. The thermally conductive portion comprises a combined layered arrangement including a metal plate and a thin film, the thin film comprising a non-metallic material and including a wall thickness of less than about 1 mm. The thin film is adapted to form at least a bottom interior surface of the water reservoir exposed to the volume of water, and the metal plate is adapted to form a bottom exterior surface of the water reservoir.

Abstract: Systems and methods are disclosed for operation of image capture devices. For example, systems may include an image sensor configured to capture images; a mechanical stabilization system, including gimbals and motors, that is integrated with the image sensor and configured to control an orientation of the image sensor; and a processing apparatus configured to: detect an occurrence of a triggering event; and, responsive to the occurrence of the triggering event, send commands to motor controllers of the mechanical stabilization system to electronically control the gimbals and motors to assume a fold-flat position, maintain the fold-flat position for a time period, and, after the time period expires, power off the gimbals and motors.

Abstract: Provided are systems, methods, and liquids related to electronic vapor devices. In one aspect, the application relates to a water-based vaporizable liquid for use in the systems, methods and electronic vapor devices. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention pertains to a system, method, and device for treating sleep disorders. The present invention is particularly useful in the delivery of carbon dioxide (CO2) to a subject and in the treatment of sleep apnea. Furthermore, integration of components with various sensors and apparatuses associated therewith and attached thereto preferably complete a rebreathing circuit in the present invention. In various embodiments of the present invention where the above components are integrated as a rebreathing circuit, a subject is both the source and recipient of a controlled concentration of carbon dioxide. In such embodiments, treatment of sleep disorders becomes much more efficient and effective.

Abstract: The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another.

Abstract: An aerosol delivery device is provided that includes a user interface including a pushbutton and a display. A control component contained coupled to the user interface controls operation of at least one functional element of the aerosol delivery device. The control component controls the display to present a menu including a plurality of menu items selectable using only the pushbutton. Each menu item of the plurality of menu items is associated with a respective functional element of the aerosol delivery device, and the control component is configured to navigate the plurality of menu items, and select a currently-presented menu item of the plurality of menu items for control of the respective functional element, in response to respective first and second types of presses of the pushbutton, the first and second types of presses being of different durations.

Abstract: The invention relates to a medical ventilation apparatus (1) having a micro-blower (2) connected fluidically to a gas circuit (3) in order to supply said gas circuit (3) with respiratory gas, a controller (4) controlling the micro-blower (2), an electronic memory (8) configured to store at least several ventilation modes (Modes 1-6), and one or more patient category selectors (6) making it possible to select at least one given patient category from several selectable patient categories (6), and one or more ventilation mode selectors (7) making it possible to select at least one ventilation mode from among several selectable ventilation modes (Modes 1-6) based on the given patient category selected by means of said at least one patient category selector (6).

Abstract: The invention relates to a modular, portable, air purifier device capable of supplying filtered or otherwise conditioned airflow to an individual. More specifically, the present invention provides an air purification system that allows for the remote detection and analysis of local ambient air quality and transmit that information to wirelessly connected devices.

Abstract: Cartridges for vaporizer devices are provided. In one exemplary embodiment, the cartridge can include an atomizer and a channel extending through the cartridge from an inlet to an outlet. The atomizer includes a wicking element that is configured to substantially draw a vaporizable material from a reservoir and into the atomizer, and a heating element that is configured to substantially vaporize the vaporizable material into a vaporized material. The channel has an airflow path and a vapor path that intersect at a first junction between the inlet and the outlet. The airflow path is configured to receive and substantially allow air to pass therethrough, and the vapor path is configured to direct the vaporized material into the first junction so that the vaporized material mixes with the air to substantially form an aerosol downstream of the atomizer. Vaporizer devices are also provided.

Abstract: To provide an inhaler cartridge and an inhaler including a novel structure. Provided is a cartridge for an inhaler. The cartridge includes: a housing including an accommodation space capable of accommodating a liquid, an air flow passage, and a partition member partitioning the accommodation space and the air flow passage in a longitudinal direction; a heater configured to be capable of heating the liquid and arranged in the air flow passage; and an air inlet port provided at a position facing the partition member and communicating with the air flow passage.

Abstract: A mask having an inner surface facing a wearer and an outer surface located opposite to the inner surface has first to fourth filters. The first filter is disposed on the outer surface of the mask and has air permeability and a water absorption capacity of 100% or more and less than 1000%. The second filter is layered on the first filter on the side of the inner surface of the mask and has air permeability and a water absorption capacity of less than 30%. The third filter is layered on the second filter on the side of the inner surface of the mask and is formed of an electret filter having air permeability and a water absorption capacity of less than 50%. The fourth filter is disposed on the inner surface of the mask and has air permeability.

Abstract: A treatment system includes a delivery device which delivers a combination of a breathing gas and frozen ice or other particles to a patient in order to induce hypothermia. The treatment system also includes a temperature system for measuring the temperature of exhaled gases and a controller which can adjust the duration or rate at which the ice particles are delivered in order to control the patient's core temperature based on the measured exhalation gas temperature.

Abstract: The invention relates to an inhaler comprising a housing with a mouth end, at least one air inlet opening and an air channel extending into the housing between the at least one air inlet opening and the mouth end, a receiving area for a fluid reservoir, an electric energy accumulator, a supply device for generating steam and/or aerosol from a component mixture extracted from the fluid reservoir and adding the steam and/or the aerosol to an air flow flowing into the air channel, wherein the supply device comprises an evaporator which can be controlled separately and a control device for controlling the supply device. The control device is connected or can be connected a data store in which at least one set predefining the evaporating parameters can be called upon and stored therein for evaporating the component mixture in the evaporator.

Abstract: A system for monitoring inspirable gas for delivery to a patient includes a branched breathing circuit having a first branch conduit and a second branch conduit. The first branch conduit is fluidly connected to a first gas source and the second branch conduit is fluidly connected to a second gas source, and the first and second branch conduits merge into a patient delivery conduit. The system includes a first flow sensor in the first branch conduit, a second flow sensor in the second branch conduit, and a third flow sensor in the patient delivery conduit. A control unit is electrically coupled to the first, second and third flow sensors. The control unit is configured to determine a blend of gas in the patient delivery circuit based on a measured flow from the third flow sensor and a measured flow from at least one of the first and second flow sensors.

Abstract: A medicant delivery method is to introduce a fluid into a container by flowing along a pressure-in pathway and out to the container. As a flow speed is stable, a connecting channel is plugged to enter the fluid to the pressure-out pathway. The fluid flows along the pressure-out pathway and then out into the container to convey the medicant at a container bottom out of the container. This method can provide more stable and more balanced forcing to gently carry the medicant all the way out of the container. Thereupon, contamination at an endoscope by the medicant bounced back from a target tissue to block vision of the endoscope can be avoided. Thus, medicant administration (hemostatic medicant for example) can be more accurate, continuity of an endoscopic surgery can be improved, performance in hemostasis can be raised, and also the total surgery time can be reduced.

Abstract: A method of delivering a substance in aerosol or powder form to the upper respiratory tract is provided. The substance is orally administered into the larynx, through the pharynx, and out from the nose while minimizing inhalation into the lungs, whereby deposition of particles in the upper respiratory tract is achieved with limited deposition in the trachea, lower airways and lungs. Also provided is an oral delivery device having a mouthpiece for oral inhalation of a flow of a substance into the upper respiratory tract and a flow restrictor for enabling arrestment of the flow minimizing inhalation into the trachea, lower airways and lungs, which provides for a deposition of particles in the upper respiratory tract with limited deposition in the trachea, lower airways and lungs. Also provided is an oral delivery device having a mouthpiece for admission of a flow of a substance into the upper respiratory tract and a flow generator for pressuring the substance into travel through the upper respiratory tract.

Abstract: In a method for performing an inhalation a reservoir is filed with a medication fluid or a medication container is connected to a designated connecting piece, a nebulizer unit is connected to a control unit and a mouthpiece, the nebulizer unit is activated, the medication fluid is atomized into a fine particulate aerosol which is emitted into an aerosol chamber formed by the nebulizer unit and the mouthpiece, and an inhalation is performed by a user. A pressure within the aerosol chamber and/or a flow rate through the aerosol chamber is measured using the control unit. The nebulizer is activated with each breath on occurrence of at least one activation criterion detected using the control unit. The nebulizer unit is deactivated with fulfillment of at least one stop criterion.

Abstract: An aerosol-generating system is provided, including: an aerosol-generating device including a power source; and a cartridge removably coupled to the device, the cartridge including a liquid storage portion including a housing having an open end and containing a liquid aerosol-forming substrate, a substantially flat heater assembly fixed to the open end of the housing and including an electrical heating element arranged in a curved manner and configured to heat the substrate to form an aerosol, and a capillary material disposed in contact with the heating element and being configured to convey the substrate to the heating element, the liquid storage portion being disposed at a first side of the assembly and an airflow channel at a second side of the assembly, the airflow channel defining an airflow path over the assembly and configured to convey the aerosol, and the power source being configured to supply power to the assembly.

Abstract: An anesthetic breathing apparatus and system, having a patient circle system for re-breathing exhaled gases by a patient a volume reflector, a fresh gas delivery line, and a gas sensor unit arranged to measure a gas stream upstream a fresh gas connection and downstream said reflector unit. The gas sensor unit provides a signal for detection of a reflector driving gas (RDG) crossing over the volume reflector during inspiration based on at least one property of the gas stream measured by the gas sensor unit. Appropriate action may be taken based on this measurement, for instance in disclosed methods.

Abstract: A breath actuated nebulizer for administration of an inhaled medication to a patient is provided with a generally cylindrical body in a horizontal orientation to the patient. Within the body is a Venturi configured to nebulizer a liquid medication in a reservoir. Within the body is a shaft integrated with a baffle and diaphragm that slides horizontally in response to the breathing of a patient. During inhalation by the patient, the diaphragm flexes shifting the baffle over the Venturi, allowing nebulization to occur. When the patient exhales, the diaphragm flexes to a default position in which the baffle is distal to the Venturi, thereby stopping the nebulization. The diaphragm is biased to rest in this default position until the patient inhales again.

Abstract: Methods and systems are provided for delivering anesthetic agent to a patient. In one embodiment, an anesthetic vaporizer includes a vaporizing chamber configured to hold a liquid anesthetic agent; a grid disposed within the vaporizing chamber; and a heating element positioned relative to the vaporizing chamber and configured to increase the temperature of the grid.

Abstract: Systems and methods for humidifying ventilator delivered breathing gases are disclosed. These systems and methods utilize a hollow cone atomizer (e.g., a pressure swirl atomizer) and/or a heating element associated with a heating circuit and/or a heating tube. In some aspect, the systems and methods utilize received flow, temperature, and/or humidity information to determine an amount of water to add to breathing gases to reach a desired humidity of the breathing gases delivered to the patient. In further aspects, the humidification system can serve as a nebulization system for delivering nebulized medicine.

Abstract: The invention relates to a control device (10) for a medical aerosol delivery device (2), a medical aerosol delivery system, a method for controlling a medical aerosol delivery device (2), a computer program element for controlling such device or system, and a computer readable medium having stored such computer program element. The control device is configured to provide inhalation length data and to select an aerosol delivery mode from at least a first aerosol delivery mode or a different, second aerosol delivery mode based on the provided inhalation length data. The first aerosol delivery mode and the different, second aerosol delivery mode are one of a target inhalation mode, a tidal breathing mode, a continuous aerosol delivery mode and breath-actuated delivery mode. Optionally, the control device (10) comprises a provision unit (11) and a control unit (13). The provision unit (11) is configured to provide inhalation length data.

Abstract: Xenon based biosensors have the potential to detect and localize biomarkers associated with a wide variety of diseases. The development and nuclear magnetic resonance (NMR) characterization of cage molecules which encapsulate hyperpolarized xenon is imperative for the development of these xenon biosensors. We acquired 129Xe NMR spectra, and magnetic resonance images and a HyperCEST saturation map of cucurbituril (CB6) in whole bovine blood. We observed a mean HyperCEST depletion of 84% (n=5) at a concentration of 5 mM and 74% at 2.5 mM. Additionally, we collected these data using a pulsed HyperCEST saturation pre-pulse train with a SAR of 0.025 W/kg which will minimize any potential RF heating in animal or human tissue.

Abstract: A ventilator includes an enclosure, a tubing configured to receive an input gas, and a flow outlet airline in fluid communication with the tubing. The flow outlet airline includes an airline outlet. The ventilator further includes a breath detection airline including an airline inlet. The airline inlet is separated from the airline outlet of the flow outline airline. The ventilator further includes a pressure sensor in direct fluid communication with the breath detection airline. The ventilator includes a controller in electronic communication with the pressure sensor and an internal oxygen concentrator in fluid communication with the tubing. The internal oxygen concentrator is entirely disposed inside the enclosure.

Abstract: Aspects of the invention provide a system for disinfecting a humidifier containing a volume of water. An enclosure, such as a humidifier, includes a first chamber, a second chamber, a humidifier component, a third chamber, and a control unit. The first chamber contains a volume of water and a portion of the water flows into the second chamber. A first set of ultraviolet radiation sources within the first chamber can be configured to generate UV-A radiation, while a second set of ultraviolet radiation sources within the second chamber can be configured to generate UV-C radiation. In operation, the humidifier component adjacent to the second chamber creates water vapor using the portion of the volume of water within the second chamber. The water vapor flows into a third chamber that contains the water vapor and releases the water vapor into the ambient.

Abstract: This invention relates to apparatus used to alter the temperature and humidity of gases. The apparatus of the present invention comprises an insufflator, humidifier and transportation means connected to delivery means to deliver humidified and heated gases to a body cavity prior to and during a medical procedure. In one form of the present invention the insufflator and humidifier are contained in the one housing, while in another form the humidifier is located proximal and external to the insufflator. The transportation means that delivers the humidified gases to the body cavity comprises a flexible tubing having located within, throughout or around it heating means. The heating means may be a heat conductive wire, a ribbon of PTC material, or a conducting wire extruded into the walls of tubing, where the tubing may be made from a PTC material or flexible plastics.

Abstract: Provided is an aerosol generating device which is capable of stopping aerosol generation at an appropriate timing. This aerosol generating device includes a power source which supplies power in order to atomize an aerosol source and/or heat a flavor source; a sensor which outputs a measurement value for controlling the power supplied; and a circuitry which controls the power supplied from the power source on the basis of the measurement value. The circuitry controls to increase a power supply amount per unit time in response to a first condition that the measured value is equal to or larger than a first threshold being satisfied, and to decrease the power supply amount per unit time in response to a second condition that the measured value is less than a second threshold greater than the first threshold and a third condition which is different from the first condition and the second condition being satisfied.

Abstract: An electronic vapor provision device comprises a body and a vaporizer. The body comprises a power cell and a processor, and the vaporizer is releasably connectable to the body. The processor is configured to enter a sleep mode when the vaporizer is connected to the body and the device is inactive for an inactive time. Furthermore, the processor is configured to leave the sleep mode and enter a usable mode when the vaporizer is disconnected from the body then reconnected to the body.

Abstract: A swivel elbow and connector assembly for a patient interface system includes a ring (128) configured to be sealingly secured in an aperture of the patient interface system and an elbow (125) swivably secured in the ring (128). The ring (128) includes a first side (128(1)) in an interior of the patient interface system and a second side (128(2)) at an exterior of the patient interface system when the ring (128) is secured in the aperture. The ring (128) comprises a first flange on the first side and a second flange on the second side, the first and second flanges defining a channel (128(3)) that sealingly engages the aperture of the patient interface system. An inner surface (128(4)) of the ring (128) is partially spherical and an outer surface (125(3)) of the elbow (125) is partially spherical and the elbow (125) and the ring (128) form a ball and socket connection.

Abstract: An electronic smoking device includes a body through which a flow path at least partially extends, an air inlet in the body that is fluidly connected to the flow path, a liquid compartment for storing a liquid within the body, a vaporizer positioned in the body and configured to receive liquid from the liquid compartment and air from the flow path to generate vaporized liquid, an outlet in the body configured to receive vaporized liquid from the vaporizer, and circuitry connected to the vaporizer. In one embodiment, the circuitry is configured to shut off the electronic smoking device based on activation time of the vaporizer. In another embodiment, the circuitry is configured to shut off the electronic smoking device after a determined amount of usage has occurred.

Abstract: In a method and system of regulating multiple anesthetic agents in a breathing circuit of an anesthetic breathing apparatus is disclosed, a primary anesthetic agent added to the breathing circuit is regulated to a set desired value of the amount of the primary anesthetic agent, and a secondary anesthetic agent in the breathing circuit is regulated to an amount of said secondary anesthetic agent that it is equal to or less than a defined threshold level, e.g. of the concentration, of the secondary anesthetic agent.

Abstract: In some embodiments, a system includes a cartridge assembly and a pen assembly. The cartridge assembly includes a mouthpiece assembly and a bracket cartridge assembly. The mouthpiece assembly includes a mouthpiece component defining a mouthpiece opening and an outer housing defining a vapor outlet and including a recessed sidewall portion. The pen assembly includes a pen housing and a bracket assembly configured to engage with the bracket cartridge assembly of the cartridge assembly such that a temperature of a coil of a wick assembly of the cartridge assembly may be increased such that a carrier material disposed near the coil may be vaporized by the coil. When the cartridge assembly is engaged with the pen housing, the recessed sidewall portion of the outer housing and an inner surface of the pen housing form a fluid path from the vapor outlet to the mouthpiece opening.