Means For Mixing Treating Agent With Respiratory Gas Patents (Class 128/203.12)
  • Patent number: 11160947
    Abstract: A swivel elbow and connector assembly for a patient interface system includes a ring (128) configured to be sealingly secured in an aperture of the patient interface system and an elbow (125) swivably secured in the ring (128). The ring (128) includes a first side (128(1)) in an interior of the patient interface system and a second side (128(2)) at an exterior of the patient interface system when the ring (128) is secured in the aperture. The ring (128) comprises a first flange on the first side and a second flange on the second side, the first and second flanges defining a channel (128(3)) that sealingly engages the aperture of the patient interface system. An inner surface (128(4)) of the ring (128) is partially spherical and an outer surface (125(3)) of the elbow (125) is partially spherical and the elbow (125) and the ring (128) form a ball and socket connection.
    Type: Grant
    Filed: April 12, 2013
    Date of Patent: November 2, 2021
    Assignee: ResMed Pty Ltd
    Inventors: Lochlan Von Moger, Matthew Eves, Memduh Guney
  • Patent number: 11154095
    Abstract: An electronic smoking device includes a body through which a flow path at least partially extends, an air inlet in the body that is fluidly connected to the flow path, a liquid compartment for storing a liquid within the body, a vaporizer positioned in the body and configured to receive liquid from the liquid compartment and air from the flow path to generate vaporized liquid, an outlet in the body configured to receive vaporized liquid from the vaporizer, and circuitry connected to the vaporizer. In one embodiment, the circuitry is configured to shut off the electronic smoking device based on activation time of the vaporizer. In another embodiment, the circuitry is configured to shut off the electronic smoking device after a determined amount of usage has occurred.
    Type: Grant
    Filed: December 18, 2020
    Date of Patent: October 26, 2021
    Assignee: FONTEM HOLDINGS 4 B.V.
    Inventors: Ramon Alarcon, Jason Healy
  • Patent number: 11141554
    Abstract: In a method and system of regulating multiple anesthetic agents in a breathing circuit of an anesthetic breathing apparatus is disclosed, a primary anesthetic agent added to the breathing circuit is regulated to a set desired value of the amount of the primary anesthetic agent, and a secondary anesthetic agent in the breathing circuit is regulated to an amount of said secondary anesthetic agent that it is equal to or less than a defined threshold level, e.g. of the concentration, of the secondary anesthetic agent.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: October 12, 2021
    Assignee: MAQUET CRITICAL CARE AB
    Inventor: Urban Blomberg
  • Patent number: 11129410
    Abstract: In some embodiments, a system includes a cartridge assembly and a pen assembly. The cartridge assembly includes a mouthpiece assembly and a bracket cartridge assembly. The mouthpiece assembly includes a mouthpiece component defining a mouthpiece opening and an outer housing defining a vapor outlet and including a recessed sidewall portion. The pen assembly includes a pen housing and a bracket assembly configured to engage with the bracket cartridge assembly of the cartridge assembly such that a temperature of a coil of a wick assembly of the cartridge assembly may be increased such that a carrier material disposed near the coil may be vaporized by the coil. When the cartridge assembly is engaged with the pen housing, the recessed sidewall portion of the outer housing and an inner surface of the pen housing form a fluid path from the vapor outlet to the mouthpiece opening.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: September 28, 2021
    Inventors: Mladen Barbaric, Kisae Kim, Sungmoon Kim, Bong Geun Kim
  • Patent number: 11110233
    Abstract: The present invention provides a single-dose powder inhalator and a method for the production thereof. It consists of an inhalator housing, which has a housing part (1), in which there is formed at least one medicament chamber (11) with a dose of a powdered medicament, and wherein the inhalator housing has an outlet opening (13?) and an outlet channel (13), which extends from the medicament chamber (11) to the outlet opening (13?). The outlet channel (13) is advantageously formed in the housing part (1). Also formed in the housing part (1) are an air inlet opening (12?), on a side of the medicament chamber (11) that is facing away from the outlet opening (13?), and an inlet channel (12), wherein the inlet channel (12) extends from the air inlet opening (12?) to the medicament chamber (11).
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: September 7, 2021
    Assignee: Perlen Packaging AG
    Inventor: Klaus-Dieter Beller
  • Patent number: 11090446
    Abstract: A fluid delivery system and a fluid conduit assembly suitable for use with the system are disclosed herein. The system includes a fluid infusion pump and a fluid conduit assembly coupled to the pump to deliver medication fluid to a user. The fluid conduit assembly includes a structure defining a flow path for the medication fluid, and a gas trapping filter coupled to the structure and positioned in the flow path. The gas trapping filter functions to filter particulates from the medication fluid and retain gas bubbles from the medication fluid.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: August 17, 2021
    Assignee: Medtronic MiniMed, Inc.
    Inventors: Sarnath Chattaraj, Kiem H. Dang, Poonam S. Gulati, Guangping Zhang
  • Patent number: 11082055
    Abstract: Systems and methods are described to time delay a signal output from an analog-to-digital converter (ADC). The ADC includes a digital sensor responsive to an analog field quantity. The digital sensor is configured to output an oversampled digital output signal at a sampling clock frequency. A time delay element is configured to receive as an input, the oversampled digital output signal and to output a time delayed oversampled digital output signal. A filter is configured to receive as an input the delayed oversampled digital output signal. The filter low pass filters and decimates to a lower sample rate the delayed oversampled digital output signal. An output includes a low pass filtered decimated delayed digital output signal, where the lower sample rate is less than the sampling clock frequency.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: August 3, 2021
    Assignee: SOLOS TECHNOLOGY LIMITED
    Inventors: Dashen Fan, Joseph Yong Kwon
  • Patent number: 11071835
    Abstract: Described herein is a dry powder inhaler which includes: a reservoir containing a dry powder formulation and an arrangement for delivering a metered dose of the medicament from the reservoir; a cyclone deagglomerator for breaking up agglomerates of the dry powder medicament; a delivery passageway for directing an inhalation-induced air flow through a mouthpiece, the delivery passageway extending to the metered dose of medicament, and an inhalable ?2-agonist having a particle size distribution of d10<1 ?m, d50=1-3 ?m, d90=3.5-6 ?m and NLT 99% 10 ?m and a lactose carrier.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: July 27, 2021
    Assignee: PHARMACHEMIE B.V.
    Inventors: Erwin Van Achthoven, Johan Keegstra, Michael Imre Goller
  • Patent number: 11065415
    Abstract: The present invention relates to a device and method of delivering inhaled Nitric Oxide (iNO) to a patient situated in a Magnetic Resonance Imaging (MRI) suite.
    Type: Grant
    Filed: December 12, 2018
    Date of Patent: July 20, 2021
    Assignee: Mallinckrodt Pharmaceuticals Ireland Limited
    Inventors: Craig Flanagan, David Newman, Jaron M. Acker, Craig R. Tolmie, Jim Potenziano
  • Patent number: 11065404
    Abstract: An electronic cigarette includes a shell and a mouthpiece. The external wall of the shell has an air inlet. An atomizer and a liquid-supply are in contact with each other. The air inlet, atomizer, and an aerosol passage are interconnected.
    Type: Grant
    Filed: April 10, 2020
    Date of Patent: July 20, 2021
    Assignee: FONTEM HOLDINGS 1 B.V.
    Inventor: Lik Hon
  • Patent number: 11045386
    Abstract: A steam heating mask having a mask body portion covering a nose and a mouth of a wearer when wearing the mask, a pair of ear hook portions provided at both left and right ends of the mask body portion, and a steam generator on the mask body portion, in which a proportion of an area occupied by the steam generator ranges from 30% to 80% with respect to an area of an entire surface of the mask body portion on a side of the wearer. The steam generator includes a first sheet on a surface of a steam generating portion on the side of the wearer with degree of air permeability being equal to or less than 7,000 sec/100 ml and a second sheet on a surface opposite to the surface of the steam generating portion with a degree of air permeability being greater than 8,000 sec/100 ml.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: June 29, 2021
    Assignee: KAO CORPORATION
    Inventors: Hideshi Oda, Yasuto Saita, Katsutoshi Hara, Keiji Yoshii
  • Patent number: 11040157
    Abstract: A drive mechanism for a medicinal inhaler, the inhaler comprising: a patient port; a canister actuable by the drive mechanism to deliver a dose of medicament to the patient port, the drive mechanism comprising: a follower which moves between a first position in which the mechanism is primed for use and a second position in which the follower engages the canister to deliver a dose of medicament to the patient port, the follower being carried on a rocker plate which pivots as the follower moves between its first and second position, wherein the rocker plate engages a switch when the follower is in its second position to indicate that a dose of medicament has been delivered to the patient port.
    Type: Grant
    Filed: April 24, 2018
    Date of Patent: June 22, 2021
    Assignee: Kindeva Drug Delivery L.P.
    Inventors: Parfes Mohammed, Neale F. Griffiths, Jack L. Williams, Richard D. Brewer, Gary K. Jepps, Christopher Dawson, James L. Onslow, Christopher B. J. Groombridge, David M. Molony, Iain G. McDerment
  • Patent number: 11034104
    Abstract: An apparatus for repairing and/or inflating a damaged and/or deflated inflatable article, such as a punctured and/or flat tire, includes a container for receiving and retaining for dispensing, a sealant composition and a compressor assembly which is releasably connectable to the container. The container has associated therewith a valve assembly which allows for controlled dispensing of the sealant composition from the container to the damaged and/or deflated inflatable article. The container is progressively and selectively movable between respective first and second positions/configurations. In the first position/configuration, the container is disposed substantially parallel to the compressor assembly and in the second position/configuration the container is disposed at substantially right angles to the compressor assembly. The first and second positions/configurations correspond to storage and dispensing positions respectively for the sealant composition from the container.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: June 15, 2021
    Assignee: TRYDEL RESEARCH PTY LTD
    Inventor: Terence Dowel
  • Patent number: 11033692
    Abstract: A device for adding a flavor and/or cough suppressant component to an inhaler is described. The device includes a housing having an interior chamber, wherein the housing includes at least one air inlet and at least one air outlet connected to the interior chamber, thereby forming an airflow pathway through the interior chamber, and at least one flavoring and/or cough suppressant component positioned within the interior chamber, wherein the housing is attachable to an exterior surface of an inhaler having at least one air inlet, such that the at least one air outlet of the device aligns with the at least one air inlet of the inhaler to form an airflow path through the device and into the inhaler.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: June 15, 2021
    Assignee: Philip Morris Products S.A.
    Inventors: Alex Stenzler, Steve Han, Arthur Slutsky, Steven Ellis, Noe Zamel, Bildad Nyambura
  • Patent number: 11020549
    Abstract: A dry powder inhalation device is disclosed. In one optional aspect, the device includes a housing, a base plate, a receptacle for a medicament and a mouthpiece. The base plate is engageable with the housing to form a main space with a main air inlet. The mouthpiece includes an inner conduit connected to its outlet and is engageable with the base plate to fluidly connect the inner conduit to the receptacle. The receptacle is fluidly connected to the main space, so that upon inhalation by a user, air can be drawn through the main air inlet into the main space and onward through the receptacle into the inner conduit. The mouthpiece and the base plate form an auxiliary space with an auxiliary air inlet, wherein the auxiliary space is fluidly connected to the main space.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: June 1, 2021
    Assignee: Alfred E. Tiefenbacher (GmbH & Co. KG)
    Inventors: David Ahern, Arron Danson, James Tibatts, Ewen Christie, Tim Evans
  • Patent number: 11000065
    Abstract: A system is disclosed that includes a holder having a pressurized chamber and configured to secure an aerosol delivery device at least partially within the pressurized chamber. A test chamber is connected to the holder, the test chamber having an inlet allowing an aerosol from the aerosol delivery device to enter the test chamber.
    Type: Grant
    Filed: August 2, 2017
    Date of Patent: May 11, 2021
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, CHARLES R. DREW UNIVERSITY OF MEDICINE AND SCIENCE
    Inventors: Theodore Friedman, Xuesi Max Shao
  • Patent number: 11000652
    Abstract: A dry powder inhaler may include at least one air inlet, at least one air outlet, an air channel between said air inlet and outlet, and at least one medicament reservoir. The inhaler may include a dosage mechanism for arranging at least one dose of a medicament from said medicament reservoir between the air channel and the air outlet such that said at least one dose may be delivered upon inhalation at said air outlet. The dosage mechanism may include a dose disc with at least one cavity, wherein the dose disc may be rotatable between a dose collecting position, in which the cavity may be positioned in the medicament reservoir, and a dose administering position, in which the cavity may lie underneath the air channel. The inhaler may also include a floor disc abutting the dose disc underneath the cavity to form a bottom of the cavity for radial emptying of the medicament from the cavity during inhalation.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: May 11, 2021
    Inventor: Orest Lastow
  • Patent number: 11000667
    Abstract: A breathing apparatus has a first delivery device for adding a volume of a substance to a gas flow, the delivery device having a gas inlet and a gas outlet. A unit monitors a presence of the substance in a gas downstream the delivery device using a first sensor unit at the gas outlet that provides a first measurement value based on an acoustic property of a gas in a first conduit. A second sensor unit at the gas inlet provides a second measurement value based on an acoustic property of a gas present in the second conduit. A control unit determines the presence of the substance based on the first measurement value or based on a comparison of the first measurement value and the second measurement value.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: May 11, 2021
    Assignee: Maquet Critical Care AB
    Inventors: Erik Cardelius, Magnus Hallback, Par Emtell, Lars Wallén
  • Patent number: 10994116
    Abstract: An infusion pump includes a reusable housing unit, a disposable reservoir, and a cap fit on the reservoir, wherein the cap includes a conduit for fluid communication. An aseptic connector assembly includes first and second occlusions in the reservoir and the cap. A pull assembly extends from the aseptic connector assembly and forms the first and second occlusions. The pump has three states. In a storage state, the reservoir is separate from the housing unit and the first and second occlusions cooperate to occlude a wet path extending from the reservoir through the conduit in the cap. In a ready state, the reservoir is applied to the housing unit but the wet path is still occluded. In a use state, the reservoir is applied to the housing unit, the first and second occlusions are removed from the aseptic connector assembly, and the wet path is opened for communication.
    Type: Grant
    Filed: June 30, 2018
    Date of Patent: May 4, 2021
    Assignee: BioQ Pharma Incorporated
    Inventors: Thomas T. Donze, Ralph I. McNall, III, Joshua W. Kriesel, Serena Joshi
  • Patent number: 10987474
    Abstract: An aerosol delivery system that includes an aerosol generator that aerosolizes a fluid for delivery to a patient as a patient inhales. The aerosol delivery system includes a pump coupled to the aerosol generator that pumps the fluid to the aerosol generator, and a breath sensor that emits a signal as the patient breathes. A controller couples to the aerosol generator, the pump, and the breath sensor. In operation, the controller receives the signal from the breath sensor, controls a flow of fluid to the aerosol generator in response to the signal, and controls the aerosol generator to start aerosolizing the fluid before the patient inhales.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: April 27, 2021
    Assignee: Stamford Devices Ltd.
    Inventors: Shaun Porter, Louise Sweeney, Ronan MacLoughlin, Jim Fink, Aidan Duffy, Claire Lillis, Conor Duffy, Fran Keating
  • Patent number: 10974006
    Abstract: The invention relates to a face mask arrangement for alternately administering a gas I containing nitrous oxide and a gas II devoid of nitrous oxide to a patient, comprising a face mask, two inlet flow lines I and II for gas I and a gas II, respectively, which flow lines end in a breathing interface, and an outlet flow line for evacuation of exhaled gas. The two inlet flow lines merge into a common inlet part. Each of the inlet flow lines I and II comprises an inlet valve I and II, each of which is capable of opening in response to inhalation and of closing in response to exhalation. The arrangement comprises a switching means enabling switching between inhalation through inlet flow line I and inlet flow line II depending on the patient's immediate need of gas I or gas II.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: April 13, 2021
    Assignee: Medclair AB
    Inventor: Jerker Sundling
  • Patent number: 10925316
    Abstract: An aerosol-generating system is provided, including a power supply; a controller connected to the supply; an aerosol-generating element connected to the controller; and a first sensor connected to the controller to provide a first signal to the controller in response to a first user input action, the controller being responsive to the first signal to switch from an off state to a ready state in which the controller prevents at least one function of the system but is responsive to a second user input action providing a second signal to the controller, and the controller comparing the second signal with stored data and switching from the ready state to an on state if the second signal matches the stored data, and in the on state the controller is responsive to a third user input action to switch to an active state in which the controller activates the function.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: February 23, 2021
    Assignee: Philip Morris Products S.A.
    Inventors: Rui Nuno Batista, Stephane Antony Hedarchet
  • Patent number: 10894141
    Abstract: Apparatus and methods for delivering humidified breathing gas to a patient are provided. The apparatus includes a humidification system configured to deliver humidified breathing gas to a patient. The humidification system includes a vapor transfer unit and a base unit. The vapor transfer unit includes a liquid passage, a breathing gas passage, and a vapor transfer device positioned to transfer vapor to the breathing gas passage from the liquid passage. The base unit includes a base unit that releasably engages the vapor transfer unit to enable reuse of the base unit and selective disposal of the vapor transfer unit. The liquid passage is not coupled to the base unit for liquid flow therebetween when the vapor transfer unit is received by the base unit.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: January 19, 2021
    Assignee: VAPOTHERM, INC.
    Inventors: William F. Niland, Owen S. Bamford, Felino V. Cortez, Jr.
  • Patent number: 10894140
    Abstract: Systems and methods of the present invention can enable high concentration NO to be delivered into ventilator breathing circuits, via a diffusing device, without generating undesirably large amounts of NO2.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: January 19, 2021
    Assignee: Mallinckrodt Hospital Products IP Unlimited Company
    Inventors: John C. Falligant, Craig R. Tolmie
  • Patent number: 10888864
    Abstract: Methods and devices for detecting metabolic activity of target cells in a sample. The target cells are concentrated in a nanoliter well having a microfilter. A reporter compound that exhibits a change in electrochemical state in response to metabolic activity of the target cells is introduced. Metabolic activity or viability of the target cells is detected based on a determined change in the electrochemical state of contents in the well.
    Type: Grant
    Filed: September 13, 2019
    Date of Patent: January 12, 2021
    Assignee: The Governing Council of the University of Toronto
    Inventors: Shana Olwyn Kelley, Edward Hartley Sargent, Justin David Besant
  • Patent number: 10857312
    Abstract: Described is a dry powder inhaler for inhalation of a dry powder composition. The inhaler includes an external housing that defines an internal passage. The inhaler also includes a mouthpiece, a compartment for holding a dry powder capsule or powder reservoir, and a powder fluidization and deagglomeration apparatus for directing airflow to the dry powder to generate airborne powder particles within the internal passage. When a user inhales through the mouthpiece, a first airflow pattern is generated that has a first airflow resistance, during which the fluidization and deagglomeration apparatus generates airborne dry powder particles within the internal passage. Upon reaching a threshold negative pressure value within the internal passage of the inhaler, a second airflow pattern is generated having a second airflow resistance that is lower than the first airflow resistance, which pulls the airborne dry powder into the user's lungs during the inhalation. Embodiments of elastomeric valves are also described.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: December 8, 2020
    Assignee: Philip Morris Products S.A.
    Inventors: Alex Stenzler, Steve Han, Arthur Slutsky, Steven Ellis, Noe Zamel, William Alston
  • Patent number: 10849602
    Abstract: An automatic robotic apparatus for conducting a minimally invasive surgical procedure includes a robotic arm having a movable member made as the multilink active actuator. The end portion of the multilink active actuator is provided with the connector to which the hollow head for a needle biopsy is attached. The operation of the U-shaped head is under full control of the robotic apparatus computer system. Results of pre-procedure studies of a site of interest and the progression of the surgical procedure are displayed on a monitor of the computer system.
    Type: Grant
    Filed: April 19, 2016
    Date of Patent: December 1, 2020
    Inventor: Dmitrii Viktorovich Alenkin
  • Patent number: 10834968
    Abstract: There is described an apparatus for heating an aerosol generating material to generate an inhalable aerosol and/or gas. The apparatus includes a housing; a receptacle within the housing, the receptacle including one or more cavities, each cavity for containing an aerosol generating material; and a heating arrangement including one or more heater elements for heating aerosol generating material contained in the one or more cavities to generate an inhalable aerosol and/or gas. The one or more heater elements are located externally of the one or more cavities.
    Type: Grant
    Filed: January 27, 2016
    Date of Patent: November 17, 2020
    Assignee: BRITISH AMERICAN TOBACCO (INVESTMENTS) LIMITED
    Inventors: Edward John, Walid Aoun, Bryan Allbutt, David Robert Seaward, David Phasey
  • Patent number: 10835691
    Abstract: A substance delivery module (4) and apparatus (2) for delivering a substance in aerosol form are disclosed. The substance delivery module (4) comprises a substance container (90), a piston (62) and an actuator (100) configured to engage the substance container (90) and urge the substance container (90) onto the piston (62), so dispensing the substance into the through passage (102) of the piston. The actuator (100) and substance container (90) are mounted in the substance delivery module (4) for relative motion, such relative motion bringing the actuator (100) into engagement with the substance container (90). The substance delivery module (4) may be assembled with an aerosol generator (10) and an aerosol delivery conduit (14) to form an apparatus (2) for delivering a substance in aerosol form. The apparatus (2) may further comprise a control module (6).
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: November 17, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Anthony Dyche, Ian Thomas Petherbridge
  • Patent number: 10835694
    Abstract: A dry powder medicament inhaler for metering an inhalation of dry powdered medicament may include at least one inlet and at least one outlet, wherein a communication between said inlet and outlet at least includes a mixing and deaggregation chamber and at least two dosage communications between the inlet and the chamber. The inhaler may also include a dosage mechanism for arranging at least one dose of a medicament between the inlet and the chamber, such that said at least one dose may be delivered upon inhalation at said outlet through said communications. The inhaler may further include a locking mechanism, wherein on moving the dosage mechanism from a dose collecting position to a dose administering position the locking mechanism may be moved from an unlocked to a locked position preventing the metering of any further doses prior to resetting of the locking mechanism. Instead of a locking mechanism, the inhaler may include a dosage indicator or a counterweight mechanism.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: November 17, 2020
    Assignee: Iconovo AB
    Inventors: Orest Lastow, Peter Jennfors
  • Patent number: 10828445
    Abstract: A tracheostomy guard couples with a patient interface to reduce the risk of occlusion of the patient interface. The tracheostomy guard has features that may prevent accidental disconnection from the patient interface while enabling suction to be applied to a patient. The tracheostomy guard may prevent patient secretions from being communicated with a caregiver in use.
    Type: Grant
    Filed: July 22, 2016
    Date of Patent: November 10, 2020
    Assignee: Fisher & Paykel Healthcare Limited
    Inventors: Stephen William Kavermann, Andrew Chi Lup Lau, Andrew Paul Maxwell Salmon
  • Patent number: 10821245
    Abstract: The present disclosure pertains to a pressure support system (10) configured to deliver a pressurized flow of breathable gas to the airway of a subject (12), the pressure support system comprising: a pressure generator (14) configured to generate the pressurized flow of breathable gas; one or more sensors (18) configured to generate output signals conveying information related to whether the subject is ready to receive breath stacking therapy; and one or more processors (20) configured to execute computer program modules, the computer program modules comprising: —a control module (52) configured to control the pressure generator to generate the pressurized flow of breathable gas according to a pressure control therapy regime, —an event module (54) configured to determine breath stacking events responsive to the output signals indicating that the subject is ready to receive breath stacking therapy, and —a breath stacking module (56) configured to, responsive to the determination of a breath stacking event, con
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: November 3, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Bernard F. Hete, William Anthony Truschel
  • Patent number: 10806501
    Abstract: This invention relates to the treatment of a patient's lung, for example, a lung exhibiting chronic obstructive pulmonary disease (COPD) and in particular to methods and devices for affecting lung volume reduction, preferably for achieving acute or immediate lung volume reduction following treatment. The lung volume reduction is effected by delivering a condensable vapor at a temperature above body temperature to the desired regions of the patient's lung to damage tissue therein. Blood flow and air flow to the damaged tissue region is essentially terminated, rendering the target region non-functional. Alternative energy sources may be used to effect the thermal damage to the lung tissue.
    Type: Grant
    Filed: April 30, 2017
    Date of Patent: October 20, 2020
    Assignee: Uptake Medical Technology Inc.
    Inventors: Robert L. Barry, Brian Cran, Dean T. Corcoran, Sheldon K. Lee
  • Patent number: 10806888
    Abstract: A respiratory assistance device (1) for a patient, includes a tubular element forming a main channel (5) (207) which is to be connected via the distal end (7) thereof to an airway of the patient, the main channel connecting to the exterior of the respiratory system of the patient via the proximal end (6) thereof, the device further including at least one auxiliary channel (8) (209) allowing the injection of jets of breathable gas for ventilation of the patient via the distal outlet openings (17) of the auxiliary channel(s), the outlet openings opening out into the main channel in the vicinity of the distal end thereof, deflection elements (14b) (14a) allowing the deflection of gas jets to the interior of the main channel, and an internal jet separator, coaxial and central to the main channel, which further ensures diversion of the flow for expired gases.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: October 20, 2020
    Assignees: VYGON
    Inventors: Georges Boussignac, Jean-Luc Carrez, Elodie Bertheuil, Laurent Lesimple Bobert, Cyril Riga
  • Patent number: 10780239
    Abstract: A system for controlling patient sedation and spontaneous breathing intensity includes a ventilator system that delivers ventilation to the patient. The system further includes a spontaneous breathing control module configured to determine a first spontaneous breathing intensity at a first sedative status of the patient, and a second spontaneous breathing intensity at a second sedative status of the patient. A sedation/breathing relationship is then defined between spontaneous breathing intensity and sedative status for the patient based on the first and second sedative statuses and the first and second spontaneous breathing intensities. The spontaneous breathing control module then receives a desired spontaneous breathing intensity for the patient and determines a desired sedative status that achieves that desired spontaneous breathing intensity based on the sedation/breathing relationship.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: September 22, 2020
    Assignee: General Electric Company
    Inventors: Mika Olli Kristian Sarkela, Erkki Heinonen
  • Patent number: 10765818
    Abstract: A dry powder inhaler with a blister folding device can include a housing to receive a single blister containing a dose of medicament for inhalation by a user, and a mouthpiece through which a dose of medicament is inhaled by a user and a blister opening device. The blister opening device can include a blister support element for supporting a blister containing a dose of medicament for inhalation by a user, and a blister folding element co-operable with the blister support element. The blister folding element and the blister support element can be movable relative to each other between a first position, for insertion of the blister into or onto the blister support element, and a second, burst, position in which the blister folding element has co-operated with the blister support element.
    Type: Grant
    Filed: November 6, 2015
    Date of Patent: September 8, 2020
    Assignee: Vectura Delivery Devices Limited
    Inventors: Roger Clarke, Peter Wilson
  • Patent number: 10744283
    Abstract: A tidal dry powder inhaler comprising: a miniature pressure sensor, a sensor port of said sensor being pneumatically coupled to a flow channel through which a user can inhale; a processor configured to process data received from a sensing element of the sensor to make a determination that inhalation of a spontaneous breath through said flow channel is in progress; a controller configured to, responsive to said determination, issue a start dosing signal; and a dosing mechanism configured to release dry powder medicament into the flow channel during inhalation of said spontaneous breath in response to receiving said signal.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: August 18, 2020
    Assignee: MicroDose Therapeutx, Inc.
    Inventors: Mark Steven Morrison, Douglas E. Weitzel
  • Patent number: 10737051
    Abstract: A nitric oxide delivery system can include a cassette which is a single use disposable component used to store liquid N2O4, activate upon operator demand, convert N2O4 to NO2 via a heating element(s) controlled by a console to deliver NO2 at a controlled flow rate, direct concentrated NO2 to a contained pair of conversion cartridges and exhaust NO gas to the console for delivery to the patient.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: August 11, 2020
    Inventors: Barry N. Gellman, Eddie Tajudeen, Lucas Gamero, Joshua Hopkins, Edward E. A. Bromberg, Ryan Denton, Bryan J. Johnson, David Fine
  • Patent number: 10729185
    Abstract: An aerosol delivery device is provided that includes a user interface including a pushbutton and a display. A control component contained coupled to the user interface controls operation of at least one functional element of the aerosol delivery device. The control component controls the display to present a menu including a plurality of menu items selectable using only the pushbutton. Each menu item of the plurality of menu items is associated with a respective functional element of the aerosol delivery device, and the control component is configured to navigate the plurality of menu items, and select a currently-presented menu item of the plurality of menu items for control of the respective functional element, in response to respective first and second types of presses of the pushbutton, the first and second types of presses being of different durations.
    Type: Grant
    Filed: December 27, 2018
    Date of Patent: August 4, 2020
    Assignee: RAI STRATEGIC HOLDINGS, INC.
    Inventors: Raymond Charles Henry, Jr., Glen Joseph Kimsey, Frederic Philippe Ampolini, James William Rogers
  • Patent number: 10722664
    Abstract: A hand operable inhalator for dispensing a powdery substance, in particular a pharmaceutical substance, with a supply chamber, a discharge channel and a dosing chamber, wherein the discharge channel protrudes into the supply chamber, and the dosing chamber and discharge channel can be moved relative to each other. In order to indicate an inhalator for dispensing a powdery substance that makes the dosing chamber advantageously fillable, the discharge channel can be rotated around a rotational axis, and that the dosing chamber can be filled while the discharge channel rotates. The inhalator can have a dosing chamber that can be moved from a closed into an open state and vice versa. The inhalator can have a discharge channel that incorporates a turbulence means, which has a helically running wall and is to carry a flow while discharging air provided with the substance.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: July 28, 2020
    Inventor: Alfred Von Schuckmann
  • Patent number: 10698426
    Abstract: Fluid control systems, including mass flow control systems, mass flow ratio control systems, and mass flow and ratio control systems, as well as corresponding methods for fluid control are provided. These systems allow one shared pressure sensor to be used for multiple flow channels, and a controller which can accurately determine mass flow on the basis of fluid pressure detected by this shared pressure sensor.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: June 30, 2020
    Assignee: MKS Instruments, Inc.
    Inventors: Junhua Ding, Michael L'Bassi, Wayne Cole
  • Patent number: 10695512
    Abstract: An inhaler includes a main body having a canister housing, a medicament canister retained in a central outlet port of the canister housing, and a dose counter having an actuation member for operation by movement of the medicament canister. The canister housing has an inner wall, and a first inner wall canister support formation extending inwardly from a main surface of the inner wall. The canister housing has a longitudinal axis X which passes through the center of the central outlet port. The first inner wall canister support formation, the actuation member, and the central outlet port lie in a common plane coincident with the longitudinal axis X such that the first inner wall canister support formation protects against unwanted actuation of the dose counter by reducing rocking of the medicament canister relative to the main body of the inhaler.
    Type: Grant
    Filed: November 6, 2017
    Date of Patent: June 30, 2020
    Assignees: Ivax Pharmaceuticals Ireland, Norton (Waterford) Limited, Teva Pharmaceuticals Ireland
    Inventors: Declan Walsh, Derek Fenlon, Simon Kaar, Jan Geert Hazenberg, Daniel Buck, Paul Clancy, Robert Charles Uschold, Jeffrey A. Karg
  • Patent number: 10688273
    Abstract: A dual pressure respiratory assistance device including a gas source which supplies a flow of gas into an air tube having a bubbler branch and a patient branch. A first tube that is connected to the bubbler branch is at least partially submerged in a fluid. An oscillatory relief valve cycles between first and second configurations. The relief valve includes an oscillating member which captures gas released through at least one hole in the first tube when the oscillating member is in a first position. The gas in the oscillating member causes the oscillating member to rise to a second position, wherein gas is released from the oscillating member and the at least one hole is blocked when the oscillating member reaches the second position.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: June 23, 2020
    Assignee: The Board of Trustees of Western Michigan University
    Inventors: Peter Allen Gustafson, Joseph David Hudson Taylor Barnett, Stephen Chiramukathu John, Hoa Tri Le
  • Patent number: 10688261
    Abstract: Systems and methods are described for monitoring usage of a medicament dispenser—particularly an inhaled medicament dispenser. While operating in a low-power mode, a first sensor is monitored for a signal indicative of handling of the medicament dispenser by a user. In response to detecting such handling, the device exits the low-power mode and begins to monitor a second sensor for a signal indicative of dispensing of the medicament. The usage monitoring device can be embodied as an attachment configured to be selectively coupled to one of a variety of different inhalers including, for example, a Diskus-type inhaler and a Respimat-type inhaler.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: June 23, 2020
    Assignee: Reciprocal Labs Corporation
    Inventors: John David Van Sickle, Greg Tracy, Mark Gehring, Eric Hoffman, Kevin Houlihan, Chris Hallberg
  • Patent number: 10688259
    Abstract: The present invention relates to an inhalation device (1), to the use thereof, and to a kit comprising the inhalation device. The inhalation device (1) has an air inlet (14), an air outlet (15) designed as a mouthpiece or nosepiece, and a recess (17) which is designed to receive a container (2) with an inhalable substance. An air duct (L) extends from the air inlet (14) through the recess (17) to the air outlet (15). Moreover, the inhalation device (1) has at least one hollow mandrel (16, 16?) which protrudes into the recess (17) and from which at least one air delivery line (14?, 14?) extends to the air inlet (14) or at least one air outlet line (15?) extends to the air outlet (15). The inhalation device (1) is characterized in that the inhalation device (1) has two limbs (11, 12), each with a work end (11?, 12?) and with an actuation end (11?, 12?), wherein the limbs (11, 12) are connected by means of a joint (13) which lies between the work ends (11?, 12?) and the actuation ends (11?, 12?).
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: June 23, 2020
    Inventor: Klaus-Dieter Beller
  • Patent number: 10675422
    Abstract: Systems and methods for delivering medicament to a subject use one or more sensors to generate signals that represent characteristics of the ultrasonic energy emitted into or by a respiratory medicament delivery device. Parameters based on these signals indicate energy amplitude in one or more frequency ranges. Such parameters can be used to determine respiratory parameters, patient adherence, and/or other parameters.
    Type: Grant
    Filed: June 24, 2014
    Date of Patent: June 9, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Mark Steven Morrison, Dirk Ernest Von Hollen
  • Patent number: 10668243
    Abstract: A system for pressurizing liquid is described herein. The system may include a liquid reservoir and a pump coupled to the liquid reservoir, the pump to draw liquid from the liquid reservoir. A compliant volume coupled to the pump receives liquid from pump. The compliant volume is composed of an elastic material to increase pressure of the liquid. A valve coupled to the compliant volume receives pressurized liquid from the compliant volume.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: June 2, 2020
    Assignee: General Electric Company
    Inventor: Douglas Kirk Bottom
  • Patent number: 10668223
    Abstract: A dose indicating mechanism for a drug delivery device for displaying of a dose of a medicament to be dispensed by the drug delivery device includes an elongated housing extending in an axial direction and having at least a first window and a second window that are spaced apart from each other in axial direction. The dose indicating mechanism further includes a dose indicating sleeve movably disposed in the housing and having at least one dose indication coinciding with the first window to display the size of a dose actually set, and an indicator operably engaged with the dose indicating sleeve and axially displaceable relative to the housing to coincide with the second window for indicating an operational status of the dose indicating mechanism.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: June 2, 2020
    Assignee: Sanofi
    Inventors: Stefan Bayer, Wolfgang Pelzer, Michael Pfoser, Björn Wilden, Philipp Zeitz
  • Patent number: 10661040
    Abstract: The present invention provides a wearable medical support for delivery of a treatment to the nose of a subject comprising: a nose mask formed from a heat moldable sheet of thermoplastic material, said nose mask comprises an aperture dimensioned to fit the nose of the subject, said aperture is flanked by two flaps whereby each flap is configured to be in contact with at least part of a lateral side of the nose; and a device configured to close fit said aperture, said device is provided at one end with an opening for receiving the nose and at the other end with at least one coupling suitable to be connected to one or more tubes for delivery of the treatment to the nose. The present invention further provides a sheet of heat moldable thermoplastic material for molding a mask directly on a subject's nose.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: May 26, 2020
    Inventor: Jean-Michel Anthony
  • Patent number: 10651866
    Abstract: Systems and methods are described to time delay a signal output from an analog-to-digital converter (ADC). The ADC includes a digital sensor responsive to an analog field quantity. The digital sensor is configured to output an oversampled digital output signal at a sampling clock frequency. A time delay element is configured to receive as an input, the oversampled digital output signal and to output a time delayed oversampled digital output signal. A filter is configured to receive as an input the delayed oversampled digital output signal. The filter low pass filters and decimates to a lower sample rate the delayed oversampled digital output signal. An output includes a low pass filtered decimated delayed digital output signal, where the lower sample rate is less than the sampling clock frequency.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: May 12, 2020
    Assignee: SOLOS TECHNOLOGY LIMITED
    Inventors: Dashen Fan, Joseph Yong Kwon