Abstract: The invention relates to the role of Acr-DNA adducts in p53 mutagenesis in CS-related lung cancer. The distribution of Acr-DNA adducts was mapped at the sequence level in the p53 gene of lung cells using the UvrABC incision method in combination with ligation-mediated PCR. It was determined that Acr preferentially binds at methylated CpG sites. Also, Acr can greatly reduce the DNA repair capacity for damage induced by benzo(a)pyrene diol epoxide. Together these results suggest that Acr is a major etiological agent for CS-related lung cancer and that it contributes to lung carcinogenesis through DNA damage and inhibition of DNA repair. Methods and compositions are provided for either removing an exogenous toxic agent from a combustion product or for preventing the toxic or mutagenic effect of these toxic agents on cells and tissues. Methods are also provided for screening for candidate compounds that protect cells from toxic combustion products.

Abstract: An improved carbon dioxide absorber for use in a closed circuit patient breathing system has a canister insertable in the breathing circuit for receiving recirculating breathing gases. The canister contains a pelletized CO2 absorbent material that removes the CO2 from the breathing gases passing through the absorber. A quantity of the CO2 absorbent material is treated with a chemical indicator such that the chemical indicator makes a color change indicative of the state of the absorptive capacity of the absorbent material. A separate quantity of the CO2 absorbent material is treated with a second chemical indicator. The second chemical indicator changes color to indicate the degree of dryness of the CO2 absorbent material. The second chemical indicator may comprise cobalt chloride and serves to indicate the potential for excessive heat generation and toxic gas generation conditions within the CO2 absorbent canister.

Abstract: The present invention relates to an apparatus and process for oxygen concentration that makes possible the production of highly purified concentrated oxygen by modifying the structure of the adsorption bed and with various valves coupled thereto, and which can increase purity of the oxygen produced and reduce mechanical energy and consumption of electricity of the air compressor.

Abstract: A water transport assembly, is provided including a housing having a first chamber therein, which is accessible through an opening in the housing. The housing additionally includes a sample inlet port and a sample outlet port, both of which are in fluid communication with the first chamber. A flat ion exchange membrane is attached to the housing in a plane over the opening in the housing, to seal the opening in a vapor tight seal. Water will pass through the membrane based upon the vapor pressure on each side of the membrane, to either dry or humidify sample passing through the first chamber. When the flat ion exchange membrane is a flat, thin ion exchange membrane it is preferable that the thin ion exchange membrane have a thickness of between about 0.1 and about 3.0 mils.

Abstract: The present invention provides a gas-delivery system for delivering breathable gas to a subject, comprising a source of pressurised gas, a mask cushion, a means for positioning the mask cushion for delivery of gas, and a filter for filtering particles from exhaled air. Preferably, the filter filters exhaled air only. The filter may engage a mask frame on any suitable surface of the frame in relation to the mask cushion.

Abstract: A novel and non-obvious apparatus, system, and method for managing respiratory secretions and fluids in sections of artificial airways. In an embodiment of the invention, a respiratory secretion retention (RSR) device configured to fluidly connect to an artificial airway can be provided. The respiratory secretion retention (RSR) device can include a housing that defines a passageway for the flow of respiratory gases, a chamber defined by the housing with a portion of the chamber configured to retain exhaled respiratory particulate and liquid, a patient side port coupled with the housing, which is in fluid communication with an artificial airway and at least one access port coupled with the housing were the at least one access port includes a control valve. In an aspect of this embodiment, the housing further can include an instillation port.

Abstract: A closed system suction catheter has a catheter enclosed within a flexible envelope secured between a patient end fitting and a machine end fitting. The patient end fitting has a cleaning chamber with a valve at its patient side and is normally closed so that the cleaning chamber is isolated from the patient. The valve has an outer rigid housing enclosing a one-piece elastomeric moulding of tubular shape. The elastomeric moulding has two pads projecting externally through openings in the outer housing. The elastomeric moulding also has a web extending internally across its diameter with a diametrically-extending slit aligned with the pads. A collar mounted on the housing is slidable along the housing to engage the pads so as to apply pressure across the web and open the slit, thereby allowing the catheter to be advanced to the patient.

Abstract: The present invention is a generally conical nebulizer, aerosol, filter or inhalant face mask for sealing against the atmosphere a wearer's mouth and nose, the improvement comprising a representation of a face on the outside surface with an exhaust valve located where the mouth would be located. The exhaust valve is adapted to visibly lift outward and up from the outside mask surface to imitate a flapping tongue.

Abstract: A sealing frame for a breathing mask is provided that can be adapted to the contours of the face of a mask user in a simple manner. The sealing frame (1), includes a soft plastic material (5) with embedded metal strips (6).

Abstract: Component gas is separated from a gas mixture. Component gas flow rate, or demand, is determined. One or more gas separator operating parameters is changed based on the component gas flow rate. For example, gas flow rate can be approximated by measuring a rate of pressure decay of a product tank during a time period in which the tank is not being replenished by the separating system. When it is determined that the flow rate is relatively low, operating parameters of the separating system are changed to improve system performance with the lower demand. For example, a target product tank pressure at which sieve beds are switched can be lowered when demand is lower.

Abstract: A condensate separator is provided for a coaxial tube system, which has an inner gas duct (3) and an outer gas duct (4). A first liquid duct (10) is arranged between the inner gas duct and a first collection volume (8) and a second liquid duct (11) is located between the outer gas duct (4) and a second collection volume (9). The collection volumes (8, 9) are located with a partition (7) in between in a liquid collecting container (6).

Abstract: Apparatuses for personal air filtering. In one aspect, a personal air filtering system includes nasal plugs to be inserted into the nostrils and a main body worn between the nose and mouth. In another aspect, the personal air filtering system has a housing that prevents exhaled air from entering the air filter disposed in the housing. In a further aspect, the personal air filtering system has separate vents for inhalation and exhalation.

Abstract: An electronic controller (16) controls the operation of an electrochemical oxygen generating system (14) producing a desired gas. The product gas is fed to a storage unit (12) or a regulator (28) and pulsing valve (28) controlling the gas flow to a user. A two-stage system (180) combines a low pressure 100 and a high pressure (150) gas generating subsystems. The low pressure subsystem (100) uses IMAT's (106) to pump oxygen from ambient air to generate a low-pressure. The high pressure subsystem (150) uses IMAT's (160) to pump oxygen to high-pressure oxygen storage devices (194).

Abstract: An oxygen concentrator system that includes or can be expanded to include more than one compressor is provided. The system utilizes a controller that is adapted to selectively activate or deactivate one or more of the compressors to optimize system performance and efficiency. Multiple compressors can be selected to operate at the same time, thereby enabling the system to operate at a higher peak pressure, increase the recovery of the PSA cycle, and expand the product rate. The additional compressors can also be removed when not in use so as to reduce weight of the system. In some implementations, the system housing reserves a certain amount of space for accommodating additional compressors and related components, which can be added to the system as after market parts. In other implementations, the additional compressor can be located external to the system.

Abstract: The present invention relates to an oxygen concentrator in which a pulsation detection device for detecting pulsation of oxygen supplied and a control device for controlling an amount of air supplied from a compressor based on the detection results in a pressure swing adsorption-type oxygen concentrator, which is equipped with an adsorption bed filled with an adsorbent capable of selectively adsorbing nitrogen relative to oxygen, the compressor for supplying air to the adsorption bed, a channel switching valve to repeat in a constant timing an adsorption step, in which air is supplied from the compressor to the adsorption bed to isolate concentrated oxygen and a desorption step, in which the adsorption bed is evacuated to regenerate the adsorbent and a flow rate measuring device for determining a supply flow rate of concentrated oxygen produced and an amount of oxygen produced is controlled by a feedback with a flow rate sensor by itself after paying attention to variation of a product flow rate caused by sup

Abstract: An oxygen concentration apparatus (300) according to the present invention has: pressure swing adsorption type oxygen concentration means (310); and a control means (350) that controls switching means (316) that switches between intake of pressurized air into an adsorption column (312) and exhaust from the adsorption column. The switching means is controlled based on pressure in oxygen concentrated gas in the conduit measured by pressure measuring means to adjust a cycle of adsorption and regeneration processes of the oxygen concentration means so that pressure at the upstream of flow rate adjusting means (340) can be controlled and, as a result, the need for a mechanical pressure regulating valve, that has been needed conventionally, can be eliminated.

Abstract: A filter material for removing toxins and/or environmental contaminants from a body of gas, comprising bentonite disposed within a support arranged so as to allow contact between the body of gas and the bentonite.

Abstract: A breathing protective device comprising a tubular elongated filter housing defining at least one wall between a first end and a second end, said wall having at least one opening, a filter in the filter house and a mouthpiece having an air canal with an opening arranged to be introduced into and held in the user's mouth whereby said filter house extends parallel to a line between the corners of the user's mouth, said air canal being in communication with at least one space within said housing for filtered inhalation air and exhalation air respectively, and wherein either the filter or the filter with the housing is disposable, wherein said filter is arranged to separate a first space from a second space and in that said air canal is arranged to enable supply of inhalation air from said first space via said filter and to enable exhalation air to escape via said opening from said second space.

Abstract: The processing of gas mixtures, in particular, of respiration gases for ventilated patients. The processing according to the invention relates, in particular, to the use of selective gas separation membranes for the retention of noble gases in the exhaled air of ventilated patients. The gas separation membrane is an active separator which is integrated in a ventilator. The separation membrane separates the noble gases from the remainder of the residual of the exhaled air by selectively retaining the noble gases. Thus, it is possible to provide a ventilator which enables the application of noble gases, in particular xenon, as an anesthetic preferably with low loss and as simple as possible.

Abstract: A powered air-purifying respirator that includes an enclosure, defining a single contiguous enclosed interior, an inlet duct, including an inlet and a distribution portion, that guides ambient air to the interior of the enclosure, a plurality of filter canisters disposed within the interior of the enclosure, and a blower that forces air through the at least one inlet, into the interior of the enclosure and through the plurality of filter canisters to produce filtered air suitable for breathing. A valve controls the flow of ambient air through the inlet duct. A fluid dam, disposed in an air path between the inlet and the filter canisters prevents liquids from reaching the filter canisters. The enclosure is reinforced and is adapted to provide protection for the filter canister from flame and heat while the filter canister is in use. A recirculation valve recycles previously-filtered air back into the enclosure.

Abstract: A process modifies the surface diffusion and wetting characteristics of a microporous material such as active carbon or silica, by applying a plasma of polymer precursor monomers to an external surface of the material to modify its adsorption properties, the microporous material obtainable thereby being modified by presence of a nanolayer of polymeric material extending over said external surface around the pores to partially occlude pore openings to a predetermined extent, but the nanolayer does not substantially infiltrate the pores of the microporous material.

Abstract: A facepiece insert (16) that has a fluid communication component (30, 32) non-integrally joined to a supporting portion (34). The insert can be made by (a) providing at least one supporting portion (34) of a facepiece insert (16); (b) providing at least one fluid communication component (30, 32) separately from the supporting portion (34) of the facepiece insert (16); and (c) securing the at least one fluid communication component (30, 32) to the at least one supporting portion (34).

Abstract: Device for extracting particles from exhaled breath, comprising a cooling system (16) for creating droplets by condensation of the water vapour contained in the exhaled breath; a droplet recovery unit (7) provided with a side wall (2) having a grid form and converging towards an outlet opening (9), allowing the droplets attracted towards said side wall (2) to flow along the latter towards the outlet opening (9); and a discharge electrode (1) mounted inside the droplet recovery unit (7), said side wall (2) of said droplet recovery unit (7) defining a counter electrode to said discharge electrode (1) in order to attract droplet-collecting particles carried by exhaled breath towards said side wall (2).

Abstract: A rapid cycle pressure swing adsorption oxygen concentration method uses a mechanical valve that has at least one cam-actuated flow control valve to switch flow of fluid, such as compressed air coming into a sieve tank that is fitted with molecular sieve materials. The cam-actuated flow control valve is repeatedly actuated by the rotating cams to become open or closed to complete a cycle that precisely controls the flow direction, pressure conditions and pressurized timing in the sieve tank whereby performance and efficiency of producing rapidly oxygen is high.

Abstract: Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.

Abstract: An adsorbent is described. The adsorbent may include a membrane and an adsorbent material encapsulated within the membrane. An inhalation device is also described. The inhalation device may include a housing and a membrane within the housing. The membrane may encapsulate an adsorbent material. The membrane may be positioned such that airflow through the housing passes across but not through the membrane.

Abstract: A method and system for removal of nitrous oxide and volatile halocarbon gas components from waste anesthetic gases using a low-flow scavenging or reclamation system preferably including an intelligent waste anesthetic gas collection unit fluidly coupled between each individual anesthetic machine and the waste gas evacuation manifold. Through a system including a collection chamber, a pressure detector, and a exhaust valve which is actuated based on the detected pressure in the collection chamber, the waste anesthetic gas collection unit allows flow to the waste suction manifold only in the presence of waste gas and interrupts all flow into the suction manifold when no waste gas is present.

Abstract: The invention relates to a medical device for producing oxygen, wherein the device comprises means for providing first conditions, and means for changing said first conditions to second conditions, the device being configured to during a charging phase extract oxygen from air by, under said first conditions, bringing said air (A) into contact with an agent (SfF) constituted by a reversibly oxygen-fixating agent, i.e. an oxygen selective material, such that the oxygen of the air is adsorbed by said agent, and to remove nitrogen under said first conditions, and configured to during a discharging phase release the oxygen from the agent by means of changing said first conditions to said second conditions. The invention also relates to a method for producing oxygen for individual medical purposes.

Abstract: The present invention comprises nontoxic, environmentally friendly triclosan-containing antimicrobial filters composed of two layers, a filtering layer and a backing layer used to trap any triclosan released from the filtering layer. The filter media can be used in various applications including filter closures for facemasks.

Abstract: A fluid impermeable interface between a polymer hood and an elastomeric neck dam includes a film composite material having a fluid impermeable outer surface and a fibrous backing inner surface. At least one fiber-free fluid barrier channel is formed in the fibrous backing inner surface. An adhesive disposed within the at least one fiber-free fluid barrier channel bonds the elastomeric neck dam to the fibrous backing inner surface, forming a mechanical bond and a fluid barrier between the fibrous backing inner surface and the elastomeric neck dam.

Abstract: A respiratory device includes a face seal and a unitary body that forms an interface with the face seal and includes a lens and a chassis. The chassis includes at least one port for fluidic connection.

Abstract: A device for detecting the relative humidity in a respiratory circuit is provided which includes a housing closed towards the outside by a transparent element, and towards the inside by a membrane permeable to the humidified gas passing through the equipment to which the device is applied and wherein the housing includes a humidity indicator element.

Abstract: A pneumostoma assessment and treatment system includes methods and devices for aftercare of a pneumostoma and for additional patient care utilizing a pneumostoma. The system utilizes a number of modalities to assess the health and functionality of the pneumostoma, the lungs and/or the patient as a whole. In response to an assessment of the health and functionality of the pneumostoma, lungs and patient, the tissues of pneumostoma may be treated with a treatment device and utilizing one or more different modalities to preserve or enhance the health and function of the pneumostoma and/or treat other conditions of the patient.

Abstract: Apparatus for delivering a medicament through an artificial airway connected to a patient ventilation/aspiration system without breaking the ventilation circuit comprises a manifold with an interior chamber communicating with first, second and third ports. The manifold is structured and arranged to maintain an uninterrupted ventilation pathway between the first and second ports and to provide a travel path for a suction catheter between the second and third ports, the second port being adapted for connection to the artificial airway. The apparatus further includes a catheter assembly, including a catheter with a lumen, positioned within a protective sleeve and slidable through a distal end fixture connected to the third port. The catheter assembly is structured and arranged to permit advancement of the distal end of the catheter through the manifold and artificial airway. A syringe and a suction control valve are interchangeably connectable to the proximal end of the catheter assembly.

Abstract: Disclosed is a respiratory cannula assembly to deliver and receive gases from a patient. The cannula assembly contains two oral prongs for delivering and receiving gases from the patient as well as at least one gas delivery nasal prong and at least one gas receiving nasal prong. The gas receiving nasal prong extends further into the patients nostril than the gas delivery nasal prong. The cannula assembly further contains a connector that aids in coupling to a medical device, the connector including independent oral and nasal moisture traps that remove moisture from exhaled patient gases.

Abstract: Xe exhaled from a patient is recovered with a polymeric membrane.

Abstract: The present invention is a catheter having a tube and including mechanisms that provide precision control over insertion and retraction of the catheter tube. The catheter is particularly adapted for introduction into the pulmonary system. The catheter includes an insertion depth control mechanism that acts as a stop and provides a tactile indication to the person inserting the catheter tube that a predetermined position has been reached. The catheter also includes an anti-bunching mechanism to prevent bunching of a protective sleeve disposed around the catheter tube, thereby reducing interference from the sleeve during insertion of the catheter tube.

Abstract: A device for adsorbing and desorbing anesthetic shall be improved in respect of the anesthetic supply. A sampling device (16) for removing a gas volume of the breathing gas and an anesthetic dispenser (18) are connected to the breathing gas line (8) between the adsorption filter (9) and the patient (10) in such a way that the gas volume removed and the gas volume supplied are compensated.

Abstract: The present invention relates in part to antiinfective flavononol compounds represented by formula I: Another aspect of the invention is a method for treating an infection in a subject by administering the compounds of Formula I to the subject.

Abstract: Method and device for scavenging tainted escape gas at a location proximate the patient's mouth (24) before that gas diffuses into, or otherwise reaches the personal breathing space (32, 35) of attending health care providers (38, 39). The scavenging device (50) includes, but is not limited to a suction arrangement (52) suspendable from a patient's nasal mask (40) used for administering gaseous analgesia or anesthetic such as nitrous oxide to the patient (20). A suction inlet (54) is positionable proximate the patient's mouth (24) and an exhaust outlet (56) is provided that is interconnectable with a vacuum source (46).

Abstract: A breathing circuit component includes an inlet, an outlet and an enclosing wall. The enclosing wall defines a gases passageway between the inlet and the outlet. At least a region of the enclosing wall is formed from a breathable material that allows the passage of water vapour without allowing the passage of liquid water or respiratory gases. The breathing circuit component is the expiratory limb of a breathing circuit.

Abstract: Disclosed and claimed herein are devices and method for the recovery of one or more anesthetic agents after they have been exhaled from a patient undergoing surgery and before they have been vented to the atmosphere. Typical anesthetic agents include, but are not limited to, isoflurane, desflurane, sevoflurane, and the like. Recovery of the anesthetic agents should result in numerous benefits including, but not limited to, reduction of their production costs, protection of the environment, and the like.

Abstract: In some embodiments, an oxygen concentrator may include lightweight injection molded housing components coupled to dual-pump diaphragm compressors. The oxygen concentrator may be coupled to a pressure transducer that detects a user's inhalation. The detected inhalation may signal the release of a bolus of oxygen. The sensitivity of the pressure transducer readings may be adjusted based on a detected environment. The user's breathing rate may also be determined to control the number of compressors used for increased efficiency. An ultrasonic sensor and gas flow rate meter may be used to determine an amount of oxygen being delivered to the user. Other components such as step valves and a solar panel may also be used to further conserve battery power. The oxygen concentrator may also incorporate an audio device such as a mobile phone.

Abstract: A filtration system for use in a respirator includes a base member including a chamber aperture, a rotating member including a filter that rotates with respect to the base member; and a cover with an inhale entry. The inhale entry and the chamber aperture create a path through which air enters the inhale entry, passes through the filter, and exits through the inhale chamber aperture.

Abstract: A medical ventilator includes a pressure generator for increasing a pressure of gas that produces heat during the operation thereof. A heat sink spaced from the pressure generator is provided for absorbing heat from the pressure generator. A bacteria filter requiring heating in excess of an ambient temperature for the effective operation thereof is coupled in thermal communication with the heat sink. A heat pipe is coupled in thermal communication with the heat sink and the pressure generator for conveying at least part of heat produced by the pressure generator to the bacteria filter via the heat sink.

Abstract: Method for making a filter cartridge that is suitable for attachment to a respiratory mask. The method comprises the steps of (a) providing a mass of filter material; (b) providing a filter cartridge housing that has an inlet and outlet and a sidewall that includes sheet material; and (c) thermoforming the sheet material of the housing sidewall around at least part of the mass of filter material to place the housing sidewall in direct contact with the mass of filter material to encapsulate the filter material so that fluid is prevented from passing through the filter cartridge from the inlet to the outlet without being filtered by the mass of filter material.

Abstract: A direct current motor having a fixed stator coil module and a magnetic rotor that can be rotated around the perimeter of said module and forming an impeller at the same time. The coils, terminal and electric connecting lines as well as upstream motor control and voltage converter modules are embedded in a non-conductive casting compound. Power is supplied from an intrinsically safe accumulator or battery pack at a voltage that is still considered intrinsically safer using a higher current value to match the required motor output. The filter and blower unit can be used in zone “0” potentially explosive atmospheres.

Abstract: A reusable facemask includes a filter layer of material adapted to trap particles having a size range of known contaminant particles; and a porous layer of material located adjacent to the filter layer and adapted to continually sanitize contaminant particles trapped by the filter layer and contaminant particles passing through the porous layer by releasing free ions of elements selected from the group consisting of silver and copper.

Abstract: A method for absorbing an anesthetic, heat and moisture in an anesthesia system is disclosed herein. The method includes providing a first material configured to absorb an anesthetic transferred from a patient. The method also includes providing a second material configured to absorb heat and moisture transferred from the patient. The method also includes combining the first material with the second material in order to produce a single composite material adapted to generally simultaneously absorb the anesthetic, heat and moisture.

Abstract: A tracheal cannula of the invention includes a breathing path for supplying and discharging air formed between a basal end for connection with a breathing tube extending from an external artificial respirator and a distal end for insertion into a patient's trachea, and a trachea side opening formed at the distal end of the breathing path. Besides and along the breathing path, a suction path is provided for sucking phlegm accumulated in the patient's trachea. A phlegm suction opening is formed in a region of a wall of the suction path on the side of the inner wall of the trachea between the distal end of the breathing path and a cuff, the phlegm suction opening facing the inner wall of the trachea.