Methods Patents (Class 128/898)
  • Patent number: 10689621
    Abstract: The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate synthetic collagen fiber with a plurality of cells and applying a strain and/or stress to the at least one elongate collagen fiber to induce the cells to differentiate into target phenotypes, e.g., tendon or ligament phenotype cells (and/or fibroblasts), typically with an extracellular matrix of collagen to organize into a tissue on the at least one collagen fiber.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: June 23, 2020
    Assignee: MiMedx Group, Inc.
    Inventor: Thomas J. Koob
  • Patent number: 10688726
    Abstract: A method for producing a customised orthopaedic implant is provided. The method involves scanning a bone from which a diseased region of bone will be resected to obtain a three dimensional digital image of an unresected volume of bone; scanning the bone after a diseased region of bone has been resected to obtain a corresponding three dimensional digital image of a resected volume of bone; and comparing the three dimensional digital image of the unresected volume of bone to the corresponding three dimensional digital image of the resected volume of bone to estimate a volume of bone that has been resected. The estimate of the volume of bone that has been resected is used to design a customised orthopaedic implant that substantially corresponds to the configuration of the resected volume of bone, the implant being configured to substantially restore a biomechanical function of the bone. Finally the customised orthopaedic implant is manufactured and provided for insertion into the resected region of bone.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: June 23, 2020
    Assignee: Royal Melbourne Institute of Technology
    Inventors: Darpan Shidid, Martin Leary, Milan Brandt, Peter Choong
  • Patent number: 10688292
    Abstract: Devices, systems and methods for magnetically assisted agent delivery are included. These devices, systems, and methods make use of a plurality of magnets or magnetic configuration.
    Type: Grant
    Filed: November 24, 2012
    Date of Patent: June 23, 2020
    Assignee: University of Maryland
    Inventors: Benjamin Shapiro, Isaac B Rutel
  • Patent number: 10687934
    Abstract: A new method for the treatment of ocular disease and injury is provided. The method involves the administration of a biocompatible implant, the porcine small intestinal serosa (or serous membrane), as graft/patch directly to the eye, for inducing restoration, remodeling, and repair of a tissue in a variety of injuries or conditions in the cornea, conjunctiva, and/or the eyelid due to trauma, diseases, or surgery. A focus on product interactions, safety profile has been fully defined and the membrane is reasonable in process, easy and convenient to prepare and significant in therapeutic effect. A simple standardized and straightforward method has been developed to fabricate this ultra-thin, delicate, and transparent material. Derived from well-defined mechanical strength, the serous membrane demonstrates consistency and flexibility that provides agile solutions for the physician.
    Type: Grant
    Filed: July 5, 2016
    Date of Patent: June 23, 2020
    Inventor: Carlos A. Alvarado
  • Patent number: 10683494
    Abstract: Methods of enhancing stem cell therapy through the administration of low level light energy are provided in several embodiments. Some embodiments comprise irradiating stem cells before or after implantation at a target tissue having loss of function due to damage or disease, with a resultant increase in the efficacy of the cell therapy. In some embodiments, light energy enhances one or more of the viability, proliferation, migration or engraftment of the stem cells, thereby enhancing the therapeutic effects of the irradiated cells during cell therapy.
    Type: Grant
    Filed: July 29, 2010
    Date of Patent: June 16, 2020
    Assignee: Pthera LLC
    Inventors: Jackson Streeter, Luis De Taboada
  • Patent number: 10682120
    Abstract: An endoscopic instrument includes: a body extending in a lengthwise direction, and having a first channel and a second channel parallel to each other; and an optical portion provided with an incident surface formed at an end part of the first channel so as to receive an external image, the optical portion disposed at the first channel, wherein the second channel is formed such that a laser module is insertable thereinto, and the laser module is configured to output laser in a direction crossing the lengthwise direction, and wherein the incident surface is formed to be inclined from a sectional surface of the first channel, such that the optical portion captures an image disposed on a path of the outputted laser. With such a configuration, a surgery can be performed through a single punched hole.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: June 16, 2020
    Assignee: KMEDISYS
    Inventors: Ki Bong Kim, Jay Bong Kark
  • Patent number: 10682254
    Abstract: A microsurgical device and methods of its use can be used for treatment of various conditions including eye diseases, such as glaucoma, using minimally invasive surgical techniques. A dual-blade device can be used for cutting the trabecular meshwork (“TM”) in the eye. The device tip provides entry into the Schlemm's canal via its size (i.e., for example, 0.2-0.3 mm width) and configuration where a ramp elevates the TM away from the outer wall of the Schlemm's canal and guides the TM to first and second lateral elements for creating first and second incisions through the TM. The dimensions and configuration of the blade is such that an entire strip of TM is removed without leaving TM leaflets behind and without causing collateral damage to adjacent tissues.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: June 16, 2020
    Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
    Inventor: Malik Y. Kahook
  • Patent number: 10682219
    Abstract: An intraluminal device and method of fixation of an intraluminal device to resist distal migration in a mammalian lumen or hollow organ that is subject to peristalsis, according to an aspect of the invention, includes spaced apart wall portions connected with a connector. The wall portions are configured to the size and shape of a portion of the lumen or hollow organ and the connector is configured to be positioned against a wall of the lumen or hollow organ. The intraluminal device is positioned in a mammalian lumen or hollow organ that is subject to peristalsis. The device is fixed in the lumen or hollow organ against distal migration, wherein tissue lining the lumen or hollow organ bridges over the connector. The device is explanted after tissue bridges over the connector including separating the connector from one or both of the wall portions and withdrawing the connector axially from the tissue bridging over the connector.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: June 16, 2020
    Assignee: BFKW, LLC
    Inventors: James A. Foote, Frederick J. Walburn, Randal S. Baker
  • Patent number: 10682256
    Abstract: A treatment apparatus for operatively correcting myopia or hyperopia in an eye includes a laser device controlled by a control device and that separates the corneal tissue by applying a laser beam. The control device controls the laser device to emit the laser beam into the cornea such that a lenticule-shaped volume is isolated in the cornea. The control device, when controlling the laser device, predefines the lenticule-shaped volume such that the volume has a minimum thickness of between 5 and 50 ?m. For myopia correction, the minimum thickness occurs on the edge of the volume, and for hyperopia correction the minimum thickness occurs in the region of the visual axis.
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: June 16, 2020
    Assignee: Carl Zeiss Meditec AG
    Inventors: Mark Bischoff, Gregor Stobrawa, Wilfried Bissmann
  • Patent number: 10682179
    Abstract: Ablation and visualization systems and methods to access quality of contact between a catheter and tissue are provided. In some embodiments, a method for monitoring tissue ablation of the present disclosure comprises advancing a distal tip of an ablation catheter to a tissue in need of ablation; illuminating the tissue with UV light to excite NADH in the tissue, wherein the tissue is illuminated in a radial direction, an axial direction, or both; determining from a level of NADH fluorescence in the illuminated tissue when the distal tip of the catheter is in contact with the tissue; and delivering ablation energy to the tissue to form a lesion in the tissue.
    Type: Grant
    Filed: October 23, 2018
    Date of Patent: June 16, 2020
    Assignee: 460Medical, Inc.
    Inventors: Terrance J. Ransbury, Kenneth C. Armstrong, Omar Amirana, Cinnamon Larson, James Bowen
  • Patent number: 10681478
    Abstract: A device, comprising a prosthesis including an external component configured to output a signal in response to an external stimulus and a skin penetrating component configured to communicatively transfer the signal at least partially beneath skin of the recipient, wherein the skin penetrating component is configured to extend into skin of the recipient and substantially lay above a surface of bone of a recipient in abutting contact thereto.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: June 9, 2020
    Assignee: Cochlear Limited
    Inventor: Marcus Andersson
  • Patent number: 10675330
    Abstract: A method of treating a bone defect is provided. The method comprises administering to the bone defect an injectable solution comprising about 20 ?g to about 5000 ?g of bone morphogenetic protein-2 (BMP-2) in an aqueous carrier. Kits and methods of making are also provided.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: June 9, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventor: Ping Li
  • Patent number: 10667814
    Abstract: A surgical stapling apparatus including a releasable buttress material includes a cartridge assembly, an anvil assembly, a knife, and a buttress material. The cartridge assembly includes a plurality of staples and a tissue contacting surface defining staple retaining slots. The anvil assembly includes a tissue contacting surface defining staple pockets for forming staples expelled from the staple retaining slots of the cartridge assembly. The knife is disposed within a knife slot formed in the tissue contacting surface of the cartridge assembly. The buttress material includes at least one weld joining the buttress material to the tissue contacting surface of the cartridge assembly. The at least one weld is positioned across the knife slot.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: June 2, 2020
    Assignee: COVIDIEN LP
    Inventors: Gerald Hodgkinson, William Powers
  • Patent number: 10667837
    Abstract: The present application discloses apparatuses with deployable probes and blades and exemplary methods of use. In one or more embodiments of the present disclosure, an exemplary handheld apparatus for probing and cutting is provided. Such an exemplary handheld apparatus includes an elongate member having a probe and a blade associated with a first end thereof. The probe comprises a target interaction surface and is selectively movable between a retracted state and a target acquisition state. The blade comprises a cutting edge and is selectively movable between a retracted position and an extended position. The handheld apparatus may additionally include a handle associated with the second end of the elongate member that is operably connected to the probe and the blade. In some embodiments, the disclosed handheld apparatus is sized and shaped for use in endoscopic surgeries.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: June 2, 2020
    Inventor: William F. Gowski
  • Patent number: 10673347
    Abstract: The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: June 2, 2020
    Assignees: UNIVERSIDAD DE ZARAGOZA, UNIVERSITAT POMPEU FABRA
    Inventors: Hector Sarnago Andía, Óscar Lucía Gil, José Miguel Burdío Pinilla, Alejandro Naval Pallarés, Antoni Ivorra Cano, Quim Castellví Fernández
  • Patent number: 10660508
    Abstract: The present invention relates to devices and methods for use in minimally invasive procedures whereby at least one, and preferably a plurality of laparoscopic instrument heads can be delivered through a single trocar and made accessible for attachment within a body cavity to the distal end of a needlescopic instrument under direct visualization via a laparoscope. The system and procedure will produce less scarring, less pain, and a reduced risk of infection at the surgical site. An addition benefit is that, because only 1 trocar is used instead of 3-5 trocars, there is a significant cost saving in each case and the surgeon is freer to move instrument locations and add/remove instruments since a new trocar does not need to be inserted every time.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: May 26, 2020
    Assignee: INNERSPACE SURGICAL CORPORATION
    Inventors: Ricardo Alexander Gomez, Sandy Lawrence Heck, Eric William Conley
  • Patent number: 10660688
    Abstract: A cryoprotective device includes a hollow cryoprotective probe having a distal tip, a removable obturator, and at least one integral temperature sensor monitoring temperature at least adjacent the distal tip. An injector is able to inject a cryoprotective substance (CPS) through the cryoprotective probe and out the distal tip when the obturator is removed. The CPS is of a material that prevents freezing of a substance at which it is injected when adjacent cryotherapy occurs. A processor monitors temperature of the at least one the temperature sensor and can indicate if a preset limit is exceeded.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: May 26, 2020
    Inventors: Gary Kalser, Gregory L. Mayback
  • Patent number: 10661048
    Abstract: Children who experience anxiety associated with novel situations react physically and emotionally in ways that make it challenging for the child, parents, educators, and providers to proceed with the intended goal of that novel situation. Anxiety in children can be reduced by introducing fun or distracting stimuli that act on specific neural pathways. The stimuli introduced can familiarize a child with the environment in which the procedure will take place and the equipment and people which the child will meet. In the healthcare setting, by using consistent stimuli, and by disrupting anxiety at one or more of a series of stages in which anxiety typically occurs, a reduction in needed anesthesia can be achieved, which is healthier for the child and reduces the costs associated with the medical or dental procedure.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: May 26, 2020
    Assignee: Calma Co LLC
    Inventors: Courtney A. Hill, Christie Traczyk, Adam Choe
  • Patent number: 10653542
    Abstract: An obesity treatment device is provided, the device comprising: at least one operable stretching device implantable in an obese patient and adapted to stretch a portion of the patient's stomach wall and an operation device for operating the stretching device when implanted to stretch the stomach wall portion such that satiety is created.
    Type: Grant
    Filed: January 29, 2009
    Date of Patent: May 19, 2020
    Inventor: Peter Forsell
  • Patent number: 10653520
    Abstract: A method of preparing a tissue swatch comprising one or more desired thicknesses for use in the manufacture of a bioprosthetic device, the method comprising sectioning a sheet of frozen tissue to produce a tissue swatch of the one or more desired thicknesses.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: May 19, 2020
    Assignee: St. Jude Medical, Cardiology Division, Inc.
    Inventors: Jaishankar Kutty, Aaron J. Chalekian, Aditee Kurane
  • Patent number: 10653408
    Abstract: A method facilitates the treatment of the spine of a patient by providing simultaneous access through at least a first opening and a second opening formed in the patient. For example, the method can include the acts of positioning the patient on a surgical table, providing the first opening into a posterior portion of the patient, providing the second opening into a lateral portion of the patient, inserting a first device through the first opening into the patient to contact the spine in a first direction that is transverse to the coronal plane of the patient, and inserting a second device through the second opening into the patient to contact the spine in a second direction that is transverse to the sagittal plane of the patient, where the first and second openings are accessible simultaneously, and, when the first and second devises are inserted into the patient, the position of the patient is stationary with respect to a portion of the table.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: May 19, 2020
    Assignee: Warsaw Orthopedic, Inc.
    Inventors: Jeffrey W. Beale, Thomas A. Carls, Richard A. Hynes, Matthew M. Morrison
  • Patent number: 10653652
    Abstract: Methods of treating tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, ADHD or addiction with (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid or a pharmaceutically acceptable salt thereof are provided. Methods of treating tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, ADHD or addiction with (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid are provided. Also provided are therapeutic compositions that may be used to improve one or more symptoms of tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, ADHD or addiction.
    Type: Grant
    Filed: February 8, 2019
    Date of Patent: May 19, 2020
    Assignee: Ovid Therapeutics Inc.
    Inventor: Matthew During
  • Patent number: 10646221
    Abstract: An adjunct can be releasably retained on an end effector of a surgical tool, such as a surgical stapler, using a plurality of retaining elements. The retaining elements can be configured to retain the adjunct to the end effector with a mechanical force until a force is applied to the adjunct that overcomes the mechanical force, thereby allowing release of the adjunct from the end effector and into a patient's body.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: May 12, 2020
    Assignee: Ethicon LLC
    Inventors: Frederick E. Shelton, IV, Jason L. Harris, Michael J. Vendely
  • Patent number: 10652482
    Abstract: An imaging apparatus including a light source that, in operation, emits pulsed light to a measurement target; a diffusion member that is disposed between the light source and the measurement target, and diffuses the pulsed light; an image sensor that includes at least one pixel, the at least one pixel including a photodiode and a charge accumulator that, in operation, accumulates signal charge from the photodiode; and a control circuit that, in operation, controls the image sensor. The control circuit causes the image sensor to start to accumulate the signal charge with the charge accumulator in a falling period of a returned pulsed light which is returned from the measurement target to the image sensor due to the emission of the pulsed light, the falling period being a period from start to end of a decrease of an intensity of the returned pulsed light.
    Type: Grant
    Filed: May 13, 2019
    Date of Patent: May 12, 2020
    Assignee: Panasonic Intellectual Property Management Co., Ltd.
    Inventors: Takamasa Ando, Tsuguhiro Korenaga, Toshiya Fujii
  • Patent number: 10646689
    Abstract: An intravascular device delivery system has an elongated member with a flexible hypotube. The hypotube can be rotationally keyed to a steerable catheter. The flexible hypotube includes one or more cuts to allow bending of the flexible hypotube within a first plane. The steerable catheter is steerable to bend the flexible hypotube within the first plane, and longitudinally movable relative to the flexible hypotube to allow distal movement of the steerable catheter relative to a distal end of the flexible hypotube.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: May 12, 2020
    Assignee: Cephea Valve Technologies, Inc.
    Inventors: Randolf von Oepen, Sean A. McNiven, Francisco Valencia
  • Patent number: 10646226
    Abstract: Systems and methods are provided for reversibly controlling a size and/or restricting the movement of a body orifice, such as a pyloric opening, using an implantable device configured to allow a distance between opposed ends thereof to be adjusted. A device is provided having attachment members and a connector portion extending therebetween and configured such that a size of the pyloric opening is decreased upon the implantation of the device. The connector can be adjustable to allow a size of the pyloric opening to be adjusted after it has been restricted. The connector can include two or more bridge portions having different lengths such that cutting a first bridge portion can increase the distance between the attachment members so as to increase the size of the pyloric opening. To revert to a natural size of the body orifice, the entire connector can be cut or otherwise broken and/or removed.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: May 12, 2020
    Inventors: James E. Coleman, Christy Cummins
  • Patent number: 10646621
    Abstract: An apparatus is disclosed for a biofunctional molecular imprint apparatus comprising a supportive structure that cuts, punctures, retains, repairs, protects, interrogates, and/or supports the function of a body tissue or other substance; a surface material that receives and retains a molecular imprint and that is positioned to contact the body tissue or other substance during use; and a molecular imprint of a bioactive molecule that influences blood coagulation, tissue damage, pain, immune response, inflammation, infection, healing, tissue regeneration, cell adhesion, the formation of extracellular matrix, tumorigenesis, angiogenesis, bacterial growth, and/or side effects.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: May 12, 2020
    Assignee: Utah Valley University Foundation, Inc.
    Inventors: Timothy Edwin Doyle, Natalie Charlotte Sullivan
  • Patent number: 10639176
    Abstract: The present invention is directed to vascular implants and methods for fabricating the same. The implantable devices include but are not limited to stents, grafts and stent grafts. In many embodiments, the devices include one or more side branch lumens interconnected with the main lumen.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: May 5, 2020
    Assignee: Taheri LaDuca LLC
    Inventors: Brice Arnault de la Menardiere, Frederich A. L. Alavar, Robert C. LaDuca, Paul A. LaDuca, Carol M. Lasalle
  • Patent number: 10638946
    Abstract: Systems and methods for detecting truth utilizing biologic data observed during various time periods occurring prior and subsequent to the presentation of a stimulus to a subject and/or prior and subsequent to a volitional action performed by the subject in response to the stimulus. A method for creating a truth or lie scale involving: presenting a stimulus designed to evoke an action to a subject; monitoring a first change in biologic data between a first epoch and a second epoch, the first epoch occurring during presentation of the stimulus, and the second epoch occurring subsequent to presentation of the stimulus; monitoring a second change in biologic data between a second epoch and a third epoch, the third epoch occurring subsequent to the action performed by the subject; and analyzing the monitored data to create the truth or lie scale.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: May 5, 2020
    Assignee: EMTEE ASSOCIATES, L.P.
    Inventor: Michael Anselme Tansey
  • Patent number: 10631941
    Abstract: Robot system which includes a master device configured to receive an operating instruction from an operator, slave arm, storage device configured to store operating sequence information that defines processing carried out by slave arm, and control device configured to control operation of slave arm. Control device includes a receiver configured to receive an input signal, motion controller configured to determine whether operating mode of slave arm is to be automatic, manual or correctable automatic mode and control operation of slave arm in determined operating mode, and continuation determinator configured to determine whether continuation of automatic mode is permitted. In a process at which slave arm is scheduled to operate in automatic mode, after motion controller suspends operation of slave arm in automatic mode at a given step of process, continuation determinator determines whether continuation of automatic mode is permitted based on input signal received by receiver when operation is suspended.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: April 28, 2020
    Assignee: KAWASAKI JUKOGYO KABUSHIKI KAISHA
    Inventors: Yasuhiko Hashimoto, Nobuyasu Shimomura, Tsuyoshi Maehara, Masayuki Kamon, Yasushi Kurosawa, Shigetsugu Tanaka
  • Patent number: 10632325
    Abstract: The present invention is a portable non-invasive system, apparatus and method for performing light therapy or photobiomodulation upon the brain tissues through the skull and/or nostrils of a living mammalian subject for the medical purpose of stimulating the brain in-vivo. The present invention utilizes the transcranial and/or intranasal pathways as points of anatomic access and follows established principles for the conceptual approach that irradiation of the brain tissue with low level light energy of certain fixed parameters would achieve major therapeutic effects in-vivo.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: April 28, 2020
    Inventor: Lew Lim
  • Patent number: 10631996
    Abstract: An expansible intervertebral implant is disclosed, various embodiments of which comprise an elongated body along a longitudinal axis comprised between a proximal end and a distal end, a flexible arm mounted in the vicinity of the distal end of the longitudinal body and movable between: a folded-back position with the arm substantially parallel to the axis, and a deployed position with the arm not parallel to the axis and away from the body to expand said implant along an axis, by assuming the general shape of a circular arc, a means for deployment of said flexible arm for deploying the latter from the folded-back position to the deployed position, by the sliding of a proximal portion of said flexible arm with respect to the body inducing an increase in the space occupied by the implant, greater than the space of the implant in the folded-back position.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: April 28, 2020
    Assignee: LDR Medical, S.A.S.
    Inventors: Pierre Bernard, Hervé Chataigner, Craig Chebuhar, Alexander Kirgis, Ross Sherban, Samuel Lequette, Emmanuel Bougere, Aymeric Fresneau, Nicolas Roche
  • Patent number: 10631939
    Abstract: A method of supplying flux may include receiving first data at a control system identifying which of a plurality of remotely-controllable kinematic flux delivery structures is operationally coupled to which of a plurality of flux supply pathways and receiving second data at the control system identifying which of the remotely-controllable kinematic flux delivery structures is operationally coupled to which of a plurality of kinematic support structures. A system for supplying flux may include a plurality of flux supply pathways, a plurality of remotely-controllable kinematic flux delivery structures, and a control system receiving first data identifying which of the remotely-controllable kinematic flux delivery structures is operationally coupled to which of the flux supply pathways and receiving second data identifying which of the remotely-controllable kinematic flux delivery structures is operationally coupled to which of a plurality of kinematic support structures.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: April 28, 2020
    Assignee: INTUITIVE SURGICAL OPERATIONS, INC.
    Inventors: Gregory W. Dachs, II, Bruce M. Schena
  • Patent number: 10633633
    Abstract: The present invention provides a new method of obtaining muscle-derived mesenchymal stem cells from microbiopsies of mammalian origin. The invention provides for a minimally invasive methodology yielding high amounts of MSCs that can differentiate into different cell lineages.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: April 28, 2020
    Assignee: Universitè De Liège
    Inventors: Didier Serteyn, Justine Ceusters
  • Patent number: 10624636
    Abstract: A surgical stapling device includes tool assembly having an anvil assembly and a cartridge assembly including a cartridge channel and a staple cartridge supported within the cartridge channel. The cartridge channel has a pair of spaced sidewalls and a bottom wall. The cartridge assembly includes compression strips that are supported on upper edges of the side walls and are positioned to support the staple cartridge. In embodiments, each of the compression strips includes a connecting portion and the upper edge of each of the side walls defines a slot that is configured to receive the connecting portion of a respective compression strip to secure the compression strip to the side wall of the cartridge channel. In some embodiments, the tool assembly also includes a compressible pad that is supported on the bottom wall of the cartridge channel between the bottom of the cartridge channel and the staple cartridge.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: April 21, 2020
    Assignee: Covidien LP
    Inventors: John Beardsley, Stanislaw Kostrzewski
  • Patent number: 10624756
    Abstract: Various embodiments comprise an expansible intervertebral implant intended to be implanted in a space between two adjacent vertebrae to at least partly supplant an intervertebral disc, said implant being able to expand along three substantially mutually orthogonal axes so as to comply with the lordosis of the patient while still having increased stability and reliability.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: April 21, 2020
    Assignee: LDR Medical, S.A.S.
    Inventors: Pierre Bernard, Hervé Chataigner, Craig Chebuhar, Alexander Kirgis, Ross Sherban, Samuel Lequette, Emmanuel Bougere, Aymeric Fresneau
  • Patent number: 10624652
    Abstract: Methods and devices that displace bone or other hard tissue to create a cavity in the tissue. Where such methods and devices rely on a driving mechanism for providing moving of the device to form a profile that improves displacement of the tissue. These methods and devices also allow for creating a path or cavity in bone for insertion of bone cement or other filler to treat a fracture or other condition in the bone. The features relating to the methods and devices described herein can be applied in any region of bone or hard tissue where the tissue or bone is displaced to define a bore or cavity instead of being extracted from the body such as during a drilling or ablation procedure.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: April 21, 2020
    Assignee: DFine, Inc.
    Inventors: Aaron Germain, John H. Shadduck, Csaba Truckai
  • Patent number: 10627461
    Abstract: Disclosed embodiments are directed to promoting nerve growth through one or more mechanisms using an apparatus to rapidly change magnetic fields.
    Type: Grant
    Filed: October 5, 2015
    Date of Patent: April 21, 2020
    Inventors: Irving N. Weinberg, Lamar Odell Mair, Randolph Nudo
  • Patent number: 10624671
    Abstract: Methods and devices are provided for attaching a trocar to a surgical arm. For example, a surgical system is provided that has a trocar with a housing and a cannula extending distally from the housing. The housing and the cannula have a tool pathway extending therethrough for receiving a tool. The system also has a trocar support that is configured to be mounted on a distal end of a surgical robotic arm. The trocar is configured to couple to the trocar support through a variety of engagements, such as engaging the trocar in a first configuration that allows free movement of the trocar relative to the trocar support and in a second configuration in which the trocar is locked in a fixed position relative to the trocar support.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: April 21, 2020
    Assignee: Ethicon LLC
    Inventors: Jeffrey S. Swayze, Jeffery Kirk
  • Patent number: 10617762
    Abstract: Various embodiments of bulking or cushioning agents or material and related medical devices and methods are disclosed. For example, a method of performing a medical procedure in a tract of a body may include injecting a material in a liquid phase proximate a target site between a first tissue layer and a second tissue layer, allowing the material to transition from the liquid phase to the gel phase in response to a raise in temperature of the material to approximately at or above the predetermined temperature, and performing a surgical procedure on the target site. The material may have the liquid phase at temperatures below a predetermined temperature and a gel phase at temperature approximately at or above the predetermined temperature.
    Type: Grant
    Filed: March 28, 2018
    Date of Patent: April 14, 2020
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Paul Scopton, Samuel Zhong, Yem Chin
  • Patent number: 10617420
    Abstract: A surgical assembly configured to be operably attached to a surgical robot is disclosed. The surgical assembly comprises a housing and a stapling assembly. The housing comprises a first, a second, and a third drive system. The stapling assembly comprises an end effector including a staple cartridge, a distal shaft assembly, a proximal shaft assembly, and an interface. The distal shaft assembly comprises a first driver configured to rotate the end effector, a second driver configured to articulate the end effector, and a third driver configured to move axially within the end effector. The proximal shaft assembly comprises a first drive train operably responsive to the first drive system, a second drive train operably responsive to the second drive system, and a third drive train operably responsive to the third drive system. The interface is configured to operably couple the distal shaft assembly to the proximal shaft assembly.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: April 14, 2020
    Assignee: Ethicon LLC
    Inventors: Frederick E. Shelton, IV, Jerome R. Morgan
  • Patent number: 10617440
    Abstract: Surgical systems and methods for performing endoscopic release procedures are disclosed herein. In an embodiment, a surgical system includes a plane finder probe adapted to establish a cutting plane for resecting an anatomical structure, and a slotted cannula insertable over the plane finder probe to position the slotted cannula along the cutting plane.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: April 14, 2020
    Assignee: ARTHREX, INC.
    Inventors: Adam Garlock, Zachary Day, Phinit Phisitkul, Annuziato Amendola
  • Patent number: 10610165
    Abstract: The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction; localizing a central nervous system lesion; detecting, diagnosing or screening for increased intracranial pressure, pressure or disruption of central nervous system physiology as seen with concussion; or detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure or concussion by tracking eye movement of the subject.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: April 7, 2020
    Assignees: New York University, THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventor: Uzma Samadani
  • Patent number: 10611768
    Abstract: The present disclosure provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R7 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient. In another embodiment, these compounds are useful for treating respiratory dysfunction in patients by administering one or more of the compounds to a patient.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: April 7, 2020
    Assignee: Asana BioSciences, LLC
    Inventors: Scott K. Thompson, Tony Priestley, Mrinalkanti Kundu, Ashis Saha, Suvadeep Nath
  • Patent number: 10611033
    Abstract: A robotic system includes a processor that is programmed to determine and cause work site measurements for user specified points in the work site to be graphically displayed in order to provide geometrically appropriate tool selection assistance to the user. The processor is also programmed to determine an optimal one of a plurality of tools of varying geometries for use at the work site and to cause graphical representations of at least the optimal tool to be displayed along with the work site measurements.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: April 7, 2020
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Brandon D. Itkowitz, Simon P. DiMaio, Craig R. Gerbi, Theodore W. Rogers, Wenyi Zhao
  • Patent number: 10610395
    Abstract: The present disclosure describes treatment of the vasculature of a patient with an expandable implant. The implant is constrained to a reduced delivery profile for delivery within the vasculature by at least one sleeve. The implant may be constrained to other diameters, such as an intermediate configuration having a diameter larger than the delivery profile and smaller than the deployment diameter. The sleeves may be expanded, allowing for expansion of the diameter of the expandable implant, by disengaging a coupling member from the sleeve or sleeves from outside of the body of the patient. The expandable implant may comprise a number of side branch fenestrations or fenestratable portions.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 7, 2020
    Assignee: W. L. Gore & Associates, Inc.
    Inventor: Edward E. Shaw
  • Patent number: 10603507
    Abstract: A method and apparatus for determining the circadian input of a light source includes selecting a circadian input to be measured based on an action spectrum corresponding to a wavelength sensitivity of photoreceptors for a circadian regulation system, where the circadian input is configured to stimulate a retinaldehyde photopigment, and for measuring spectral intensity across the action spectrum to determine the circadian input of the light source.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: March 31, 2020
    Assignee: PROGRESSIVE LIGHTING AND RADIOMETRICS, LLC.
    Inventors: George Brainard, Gena Glickman
  • Patent number: 10603072
    Abstract: The present invention generally relates to methods for preparing a skin graft without culturing or use of biologics.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: March 31, 2020
    Assignee: KCI Licensing, Inc.
    Inventors: Sameer Ahmed Sabir, M. Josh Tolkoff, Andrew Ziegler
  • Patent number: 10603465
    Abstract: A gastric tube for use in a bariatric surgical procedure includes an elongate tube and an anchor. The elongate tube has a proximal end portion and a distal end portion and defines a lumen along a length thereof. The proximal end portion defines an opening in communication with the lumen. The elongate tube includes a blunt tip, a light source, and an outer surface. The blunt tip is formed on the distal end portion and is at least partially transparent. The light source is in communication with the blunt tip for illuminating at least the blunt tip. The outer surface extends between the proximal and distal end portions and defines a side opening in communication with the lumen.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: March 31, 2020
    Assignee: COVIDIEN LP
    Inventors: Rajat Rokde, Syed Ahmed Mushtaque, Jeetendra Bharadwaj
  • Patent number: 10603221
    Abstract: In an aspect, the device for stretching skin of a user's neck includes a stretchable body that extends along a first axis, a first end integrally connected to the stretchable body, and a second end integrally connected to the stretchable body. The device further includes an adhesion layer formed on one side of each of the first end and the second end for attaching the device to the skin of the user's neck. Each of the first end and the second end comprises a center part that is integrally formed with the stretchable elongate body, a first extension connected to the center part and extending along a second axis away from the center part, and a second extension connected to the center part opposite the first extension and extending along the second axis away from the center part and the first extension.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: March 31, 2020
    Inventor: Van J. Kantor