Abstract: In one aspect, embodiments relate to a system for performing preventative dental laser treatment. The system includes, a code reader configured to read a machine readable code, a processor configured to verify the machine readable code and prevent future verification of the machine readable code, and a laser treatment system configured to perform a laser treatment, based upon the verified machine readable code. The laser treatment system includes a laser arrangement configured to generate a laser beam, an optical arrangement configured to direct the laser beam toward a dental hard tissue, and a laser controller configured to control a parameter of the laser beam in order to heat at least a portion of a surface of the dental hard tissue to a temperature above 400° Celsius.

Abstract: A tissue expander/retractor tool works within a narrow cavity/tunnel to access a deeper structure (e.g., the mitral valve) without consuming a significant amount of space either within the small through-hole or in the vicinity of the entrance to the port. The tool provides the user with direct control of the expansion and separation of a target area. The moving parts of the tool have a closed configuration with a narrow profile for insertion/removal and an open configuration obtained using a remotely-controlled, compact pivot mechanism that provides a broad enlargement capability for the retraction jaws. A pantograph mechanism with input pivots and output pivots is coupled between the retraction jaws and a compound cable (e.g., Bowden cable). A handle is coupled to the other end of the compound cable for displacing the inner wire along the outer tube.

Abstract: The self-contouring plate system for bone fractures allows a surgeon to bridge a bone fracture, primarily in bones of complex shape where the use of plates or screws is difficult. The self-contouring plate is formed from a series of similar or identical rigid elements, the elements able to bend and rotate with respect to each other. This flexibility is initially helpful as the surgeon contours the device to the shape of the bone. When the desired shape is reached, the elements are locked into place. The length of device is adjusted by adding or removing elements, much like a necklace. Each element of the self-contouring plate includes a ball that extends away from a body, a cavity for receiving the ball of the neighboring plate, and a screw to compress the ball within the cavity.

Abstract: The present invention relates generally to medical devices, systems, and methods for use in surgery. In particular, the disclosed system and methods relate to an intervertebral spinal implant sized and dimensioned for the lumbar spine implantable via a posterior approach. The system includes an implant, instruments for delivering the implant.

Abstract: This present invention relates to drug eluting polymers, including novel biodegradable drug eluting polymers, which are added to the surface of a medical device to treat device associated complications and to deliver drug locally around the device. Methods of making polymers, for example, drug-eluting polymers, polymer compositions, and materials used therewith also are provided. The drug eluting polymers are obtained from the polymerization of macromonomers made of a connecting moiety, a biodegradable moiety and a cross-linkable moiety that are liquids at a temperature of 10° C. to 40° C.

Abstract: Provided is an information processing system including: a comparison information acquisition unit that acquires comparison information regarding iris comparison generated based on an iris image including an iris of a recognition subject; and a display image generation unit that generates a display image including an image indicating a content of the comparison information in association with positions in the iris.

Abstract: A method of treating diverticulitis while maintaining the bioactivity of the diverticulum. The devices and methods include placing an endoscopic device within a colonic lumen relative to at least one diverticulum and inserting a plurality of particles into the at least one diverticulum. The plurality of particles can include magnetic particles, non-magnetic particles, or both. The plurality of particles can partially or totally occlude the diverticulum preventing unwanted material from entering the diverticulum. Additionally, the plurality of particles can include antimicrobial and therapeutic layers that can treat diverticulitis and prevent or minimize diverticulitis from occurring.

Abstract: Prosthetic heart valve devices with tethered anchors and associated systems and methods are disclosed herein. A heart valve device configured in accordance with embodiments of the present technology can include, for example, a valve support for carrying a prosthetic valve. The valve support can be configured to be implanted at an annulus of a native mitral valve. The device can further include at least one elongated flexible member extending from the valve support in a ventricular direction, and an anchor coupled to the valve support via the elongated flexible member. The anchor can be shaped to wrap around an exterior area of an apical portion of the heart. In addition, the anchor can inhibit retrograde migration of the valve support.

Abstract: An apparatus for assembling a repelling magnet combination, comprising a first and second magnet, a first and second holding magnet, a first holding base with a first holding base first end, and a second holding base with a second holding base first end. The first and second holding magnets are positioned at the first and second holding base first ends, and the first and second magnets are magnetically attached to the first and second holding magnets respectively, with outward faces exhibiting like magnetic polarities. The first and second magnets are brought into contact by moving the first and second holding base first ends into close proximity, whereby the first and second holding magnets exert holding forces on the first and second magnets which overcome a repelling force generated therebetween, allowing a repelling force countering means, such as an adhesive, to bond the magnets together into a repelling magnet combination.

Abstract: A system for forming an anastomosis between first and second sections of a digestive tract includes Optical Scope Device (“OSD”) having a lumen extending therethrough and positioned at a first target site within the first section, OSD including an imaging component at a distal end thereof for viewing the first target site; First Endoscope (“FE”) including a working channel extending therethrough and positioned at a second target site within the second section; Capture Device (“CD”) extending from a proximal end to a distal end including a loop, CD extends through the lumen; First Flexible Element (“FFE”) extends through FE, FFE including a coupling element which passes through the loop to couple FFE to CD, connecting the first and second sections, the coupling element moving between insertion and locking configurations; and Stent having a lumen extending therethrough which provides fluid communication between the first and second sections.

Abstract: A system for presenting a severity vector includes a computing device configured to obtain a user status from a remote device, identify a user affliction as a function of a user status, generate an effect enumeration as a function of the affliction, wherein generating includes receiving an affliction training set correlating at least a first element of an affliction state and at least a first affliction result and generating an effect enumeration as a function of the affliction training set using an affliction machine-learning process, wherein the affliction machine-learning process is trained using the affliction training set, calculate a severity vector, and transmit the severity score on the remote device.

Abstract: A method of puncturing from an aorta into a left atrium using a puncturing device. The method involves a step of accessing a carotid artery and advancing a puncturing device through the carotid artery into an aorta. Advancing a sheath and a dilator over the puncturing device through the carotid artery and into the aorta such that a puncturing tip of the puncturing device is aligned with a distal tip of the sheath and a distal tip of the dilator, forming a puncturing assembly. Positioning the puncturing assembly at a target site within the aorta to gain access to a left atrium of a heart. Tenting a tissue between the aorta and the left atrium using the puncturing assembly. Creating a puncture through the tissue by advancing the puncturing device such that a channel between the aorta and the left atrium is formed.

Abstract: Improved formulations for topical treatment that ensure at least localized transdermal or systemic delivery of an active agent through skin, nails or hair follicles are disclosed.

Abstract: The disclosure provides a composition for inhibiting thrombosis. The composition includes 5 to 25% by weight of Fish Oil, 15 to 55% by weight of Willow Bark Extract, and 0.2 to 5% by weight of Vitamin E.

Abstract: A surgical tool for use with a drill bit to prevent skiving at an implant insertion site on a bone includes a cannulated sleeve having a distal end defining a burr surface. The distal end may be detachable from a body of the cannulated sleeve. The tool may be used with more than one distal end, each of the distal ends defining a burr surface having a different cutting surface from the others. The tool may form a system that includes the drill bit.

Abstract: Apparatuses and methods are disclosed for applying laser energy having desired pulse characteristics, including a sufficiently short duration and/or a sufficiently high energy for the photomechanical treatment of skin pigmentations and pigmented lesions, both naturally-occurring (e.g., birthmarks), as well as artificial (e.g., tattoos). The laser energy may be generated with an apparatus having a resonator with the capability of switching between a modelocked pulse operating mode and an amplification operating mode. The operating modes are carried out through the application of a time-dependent bias voltage, having waveforms as described herein, to an electro-optical device positioned along the optical axis of the resonator.

Abstract: Disclosed are analyte monitoring systems and methods for calibrating an analyte sensor using one or more reference measurements. These systems and methods may include using a conversion function and first sensor data to calculate a first sensor analyte level, weighting a first reference analyte measurement (RM1) and one or more previous reference analyte measurements according to a weighted average cost function, updating the conversion function using the weighted RM1 and the one or more weighted previous reference analyte measurements as calibration points, and using the updated conversion function and second sensor data to calculate a second sensor analyte level. In some aspects, the systems and methods may include updating one or more of lag parameters used to calculate the sensor analyte levels.

Abstract: A shunt comprising a flexible tube having a first, and a second end, and a central opening, having a first diameter that extends from the first end to the second end. The shunt also includes one or more restrictor bands having a second diameter around the flexible tube. The one or more restrictor bands are located between the first end and the second end of the flexible tube and the second diameter is less than the first diameter such that the restrictor band forms a restriction. The restrictor band is expandable between a first position and a second position. The restrictor band may have fracturable sections configured to fracture in responds to pressure thereby increasing a diameter of the one or more restrictor bands to a diameter greater than the second diameter. The one or more restrictor bands may comprise restrictor bands of at least two different inner diameters.

Abstract: Robotic spinal surgery systems and methods include a robotic manipulator with a tool guide and a skin incision tool to be inserted into the tool guide. A navigation system includes a localizer for tracking the patient and a base tracker of the robotic manipulator. A control system registers, with the navigation system, a line haptic object to a vertebra of the patient, the line haptic object being associated with a desired trajectory for the vertebra. In response to a user input, the control system autonomously moves the robotic manipulator to align the tool guide to the desired trajectory. The tool guide is constrained to the desired trajectory with the line haptic object to enable insertion of the skin incision tool within the tool guide to facilitate creation of the incision in the skin at the desired trajectory.

Abstract: The disclosed invention provides a transseptal insertion device which is suitable for facilitating precise and safe transseptal puncture of a cardiac interatrial septum. The transseptal insertion device includes a sheath that defines at least one lumen therein, one or more positioning balloons that are connected to a distal end of the sheath, a puncture member movably positioned within the at least one lumen, and a puncture member balloon located on the puncture member. The positioning balloons are inflated and deflated through hypotubes, and the puncture member balloon is inflated and deflated through an additional tube. The transseptal insertion device includes a wire member movably positioned in a center lumen formed in the puncture member. The wire member may be Brockenbrough needle, a radiofrequency tip needle, a radiofrequency wire, a pigtail catheter that delivers fluid or pharmaceuticals in the left atrial appendage, or a transseptal wire.

Abstract: The method of delivering an implant in an intracranial vessel includes deploying an anchor of a tethering device in an anchoring vessel forming a first fixation point and advancing a guide-sheath to a location near the anchoring vessel. The tethering device has a tether extending proximally from the anchor and the guide-sheath has at least one lumen. The method includes attaching the guide-sheath to the tether of the tethering device forming a second fixation point proximal to the first fixation point, delivering an implant through the lumen of the guide-sheath towards a treatment site distal to the first fixation point and located within an intracranial vessel, and deploying the implant at the treatment site. Related devices, systems, and methods are also provided.

Abstract: The invention concerns an intraocular lens implant for placement into an intracapsular space of a lens capsule of an eye and a composition, kit and methods related to the lens implant. The lens implant is designed for a placement into a posterior portion of the intracapsular space after removal of a native lens body and has a convex posterior surface. The lens implant is formed of one part and is manufactured from a suitable transparent non-structural cellular material. This keeps an anterior portion of the intracapsular space free of the implant which is dimensioned to comprise at most 40% of a volume of the native lens body.

Abstract: A device comprising: (a) one or more markers, some or all of which are expandable rounded members that are expandable from a stored state to an expanded state and when in the expanded state each of the expandable rounded members expand to move into contact with a lumen in an organ; and (b) one or more tissue tags connected to the expandable rounded members or the expandable rounded members being made of a magnetized material; and wherein the expandable rounded members are configured to be located within and deployed from an insertion mechanism into the lumen in the organ.

Abstract: Disclosed is an in-vivo micro-robot for nerve stretching, comprising a channel, and a movable part and a fixed part located at the channel. The movable part is disposed to be movable along the channel, the movable part sleeves the fixed part and is used for driving the fixed part to move along the channel, and the fixed part is connected to a nerve to be stretched. The in-vivo micro-robot is embedded into a patient's body through surgery, so that the extension of the nerve is accelerated and is regular and quantitative, thereby effectively solving the problems of small probability of nerve self-repair and long recovery period in traditional nerve bridging surgery.

Abstract: A method of repairing a heart valve provides intravascular access for repair of a heart valve through a ventricular trans-septal approach. An external guide catheter can be inserted through a vein of a patient into the right ventricle via the right atrium. An internal guide catheter can be inserted through the external guide and can provide access to the septum for a puncture tool to create an opening through the septum to the left ventricle. The internal guide can then be advanced into the left ventricle and used to guide a deployment catheter that deploys a repair device onto the heart valve.

Abstract: A method of treating noninfectious diarrhea in an HIV positive subject includes administering a dose of ibuprofen to the HIV positive subject at regular intervals until stool consistency is improved, diarrhea is alleviated, or the number of bowel movements per day are decreased. The dose is 400 mg of ibuprofen administered every 6 hours. The method may additionally include diagnosing the subject with noninfectious diarrhea, determining the subject does not have certain comorbidities, and/or determining that the subject is not taking any non-steroidal anti-inflammatory drugs. The method may additionally include after administering the ibuprofen, administering a clear liquids diet to the subject, administering an electrolyte supplement to the subject, and/or monitoring the subject for any bleeding from the gastrointestinal tract until stool consistency is improved, until diarrhea is alleviated, or until the number of bowel movements per day are decreased.

Abstract: A method and apparatus for bilateral stimulation (BLS) is described. An electronic device having at least a display and a camera provides a selection of different BLS sessions for a user. At least one of the sessions uses the camera to provide a real-time scene on the display as the background for the movement of the image of a virtual object. In one configuration, the image moves continuously along pattern on the display. The user either follows the image with their eyes, and/or is required to indicate to the device the position of the image on the display. In another configuration, the image is hidden from view and the user must move the camera within an active area of the display so that the image appears and the user can identify the presence of the image.

Abstract: A method and system for automated and semi-automated predictable, consistent, safe, effective, and lumen-specific and patient-specific cryospray treatment of airway tissue in which treatment duration is automatically set by the system following entry of patient information and treatment location information into the system by the user, and treatment spray is automatically stopped by the system when the automatically selected treatment duration has been achieved as determined by the system.

Abstract: Provided is a system and method for providing a non-binding allograft subtalar joint implant for surgical implant into a person's foot proximate to the ankle. This system for repair includes at least one sterile non-binding allograft subtablar joint implant provided as a pre-formed allograft rod plug “ARP” having a diameter about equal to an average width of a canal between a person's talus and calcaneus bones, the ARP being resiliently compressible and flexible. When snuggly disposed between the person's talus and calcaneus bones, the ARP compresses during normal use of the person's foot and maintains the canal in an anatomically correct alignment and reduces a tendency for abnormal motion between the person's talus and calcaneus bones. An associated method of use is also provided.

Abstract: Devices, systems, and methods for performing a transcorporeal microdecompression are described. The transcorporeal microdecompression may include a bone void plug allograft and specialized instruments for performing the procedure. This procedure may be performed under navigation and/or with robotic assistance.

Abstract: Embodiments generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incisions to form a top lenticular incision, a bottom lenticular incision of a lens in the subject's eye, an added shape between the top and bottom incisions where the added shape has no corrective power and a transition ring bisecting both the top and bottom lenticular incisions.

Abstract: A safety system for laser treatment, comprising a first sensor configured to monitor a parameter at a source and to generate first parameter data, a second sensor configured to monitor the parameter at a treatment head and to generate second parameter data, a control system configured to receive the first parameter data and the second parameter data and to determine whether the first parameter data or the second parameter data exceed a predetermined value and the control system further configured to modify an operational parameter of the source in response to a determination that the first parameter data or the second parameter data exceed the predetermined value.

Abstract: A system and method of confirming administration of medication is provided. The method comprises the steps of receiving information identifying a particular medication prescription regimen, determining one or more procedures for administering such prescription regimen and identifying one or more activity sequences associated with such procedures. Activity sequences of actual administration of such prescription regimen are captured and then compared to the identified activity sequences to determine differences therebetween. A notice is provided if differences are determined.

Abstract: A system for monitoring organ health during treatment for cancer and the like makes use of physiological imaging of the kind used for treatment monitoring and organ-specific processing to provide a comprehensive assessment of treatment side-effects.

Abstract: A system for modeling a necrotized tissue volume in an ablation procedure includes a radiology workstation designed and configured to provide a computer model of a volume of human tissue based on corporeal image data, simulate an ablation site in the computer model, detect, in the computer model, at least a preferential pathway for heated vapor produced due to ablation of the tissue, wherein the at least a preferential pathway intersects the ablation site, determine a proportion of vapor escaping to the at least a preferential pathway during an ablation procedure, determiner a heat distribution at the ablation site as a function of the distribution of vapor, and generate a simulation of a necrotized tissue volume in the volume of tissue, wherein the simulation of the necrotized tissue volume represents a volume of tissue necrotized by heat during an ablation procedure performed at the ablation site.

Abstract: A method is provided for measuring an opening of an appendage of an atrium of a subject, the method including inserting a catheter into the atrium of the subject using a transvenous approach. Thereafter, at least one loop is deployed from a wall of the catheter, such that a distal end of the loop is distal to a distal end of the catheter. Thereafter, the loop is used to measure the opening of the appendage. Other embodiments are also described.

Abstract: The present invention provides a catheter apparatus with a carrier comprising right-handed wire helixes and left-handed wire helixes that are plainly or bi-axially woven into a tubular structure. A therapeutic assembly wraps around one of the wire helixes to stabilize an associated interstice of the tubular structure. The regular shape of the carrier may be quickly recovered after the carrier is seriously bent or distorted in an intravascular treatment.

Abstract: A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.

Abstract: System for determining heart failure indicator indicative of a heart failure disease state in a subject, including processing device(s) that at least in part control signal generator(s) and receives an indication of a measured response signal from sensor(s) allowing first and second impedance measurement(s) to be performed across at least one body segment, determines a first fluid level indicator using first impedance value(s) obtained by performing the first impedance measurement(s), the first fluid indicator being indicative of a first ratio of ECF to TBW at a first time, determines a second fluid level indicator using second impedance value(s) obtained by performing the second impedance measurement(s), the second fluid indicator being indicative of a second ratio of ECF to TBW at a second time, determines a fluid level change using a difference in the first and second fluid level indicators, and, determines the heart failure indicator using the fluid level change.

Abstract: The invention relates to a pre-filled syringe, an auto-injector device comprising such pre-filled syringe, a method of administering a pharmaceutical composition with such auto-injector device, and a manufacturing method for such auto-injector device. The pre-filled syringe comprises a container and a needle. The container is filled with a pharmaceutical composition comprising epinephrine, a buffer, and water. The buffer is configured to buffer in a pH range between 3 and 4. The needle is adhered to the container by means of a urethane acrylate or urethane methacrylate acrylic light cure adhesive, which is configured to provide a pull out resistance of the needle relative to the container which is between 30 N to 100 N, preferably between 50 N to 70 N, more preferably greater than 60 N after 90 days exposure to the pharmaceutical composition at 40° C. and 75% relative humidity (RH). In an example, the pharmaceutical composition is for the treatment of an anaphylactic event.

Abstract: A surgical instrument includes a stapling assembly and an anvil that releasably couple together to compress and staple tissue. The stapling assembly includes a body having a longitudinal axis, a deck member, and a knife member surrounding the longitudinal axis. The deck member includes a deck surface having an imaginary centerline that surrounds the longitudinal axis, a first deck surface portion extending along a first angular range of the deck surface about the longitudinal axis, and a second deck surface portion extending along a second angular range of the deck surface about the longitudinal axis. A first array of staple openings is disposed on the first deck surface portion and is arranged in a first orientation relative to the deck surface centerline. A second array of staple openings is disposed on the second deck surface portion and is arranged in a second orientation relative to the deck surface centerline.

Abstract: A biopsy needle system includes a needle extending from a tissue piercing distal end to a proximal end. The needle defines a lumen extending from the distal end at least a portion of a length thereof and houses a target tissue. The system also includes an elongated member defining a channel therethrough open at a proximal end. The channel is sized and shaped to permit passage of the needle therethrough. Further, the system includes an end cap coupled to the distal end of the elongate member. The end cap includes a hole extending through a lateral wall thereof. The hole is sized and shaped to permit passage of the needle therethrough. The end cap further includes a ramp extending from the channel to the hole to guide the needle through the hole. The ramp is angled with respect to a longitudinal axis of the elongated member.

Abstract: Systems and methods for treating a plurality of tissue sites include a multi-port therapy unit. The multi-port therapy unit includes a plurality of patient-side ports each fluidly coupled to a plurality of conduits and a fluid reservoir fluidly coupled to the plurality of ports. A plurality of pressure sensors are associated with the plurality of patient-side ports to determining a pressure associated with each conduit. A controller is operatively coupled to the plurality of pressure sensors to receive treatment pressure data, monitor pressure for each pressure sensor of the plurality of pressure sensors, and signal an alarm condition if the pressure is outside of a pre-selected range. The system includes a reduced-pressure source fluidly coupled to a dressing at each tissue site through the multi-port therapy unit.

Abstract: A staple cartridge assembly comprising a tissue thickness compensator is disclosed. The tissue thickness compensator comprises a first fibrous, woven material and a second fibrous, woven material. The first fibrous, woven material comprises a density which is different than the density of the second fibrous, woven material. The tissue thickness compensator is configured to expand upon contact with a fluid in order to apply a compressive force to tissue captured within staples.

Abstract: Described herein are devices and methods of treating obstructive breathing disorders in a patient. A method may include: attaching an anchor to a dorsal region of a tongue body; applying an external force to the tongue body; and adjusting a magnitude of the external force. In some embodiments, the magnitude of the external force is adjustable across multiple levels based on one or more of: patient comfort, desired therapeutic effect, or patient wake or sleep state. In some embodiments, at least a portion of the external force is directed along an anterior direction. In some embodiments, the external force causes at least one of the following actions: anterior displacement of a portion of the posterior tongue during sleep or reducing posterior displacement of a portion of the tongue during sleep.

Abstract: Devices and methods for substantially reducing the caloric efficiency of the digestive tract by capturing food being digested in the stomach 10 and/or anywhere else in the gastrointestinal (GI) tract, absorbing or encapsulating the captured food into multiple capturing members and moving such multiple capturing members containing the ingestible encapsulated food down the GI tract, practically out of reach of the GI absorption organs, thus excluding the entrapped ingredients from being involved in the digestion and\or absorption process. The device is designed for oral delivery. The system can be comprised of liquid, food bars or a capsule system. The capsule system is comprised of an external capsule that dissolves in accordance with a temporal or ph dependent preset, which allows the food intake to be at least partially fluidic. The capsule system is further comprised of a mechanism designed to capture and isolate a portion of the food being digested.

Abstract: Apparatus for medical treatment includes a laser source, which is configured to output a beam of laser radiation. An optical device is configured to direct the laser radiation to impinge on a limbal area of an eye with optical properties chosen so as to apply a desired treatment to a tissue structure associated with a cornea of the eye within the limbal area.

Abstract: Methods of treating tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, ADHD or addiction with (1S,3S)-3-amino-4-(difluoromethylidene) cyclopentane-1-carboxylic acid or a pharmaceutically acceptable salt thereof are provided. Methods of treating tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, ADHD or addiction with (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic acid are provided. Also provided are therapeutic compositions that may be used to improve one or more symptoms of tinnitus, acute sensorineural hearing loss, Meniere's disease, Tourette's syndrome, ADHD or addiction.

Abstract: The present disclosure describes ultrasound imaging systems and methods configured to identify ovarian follicles by applying a neural network to pre-processed ultrasound image frames. Systems may include an ultrasound transducer configured to acquire echo signals responsive to ultrasound pulses transmitted toward a target region. One or more processors communicatively coupled with the ultrasound transducer may be configured to generate at least one image from the ultrasound echoes. A threshold may be applied to the image frame that differentiates pixels representative of an ovarian follicle present in the target region from other subject matter. The processors may apply a neural network to the thresholded image frame, in which the neural network determines the presence of the ovarian follicle in the thresholded image frame. The processors also may generate an indicator based on the presence of the ovarian follicle and display the indicator on a user interface.

Abstract: Apparatus and methods calculate and deliver doses of insulin and optionally glucagon into a subject. Online operation controls delivery of correction doses of insulin automatically in response to regular glucose measurements from a sensor, and offline operation calculates and delivers correction doses based on isolated glucose measurements and information gathered autonomously during preceding online operation. In another aspect, offline operation includes automatically calculating and administering meal doses based on information gathered autonomously during preceding periods of online operation. Both methods include generating relevant control parameters tailored to the individual and continually converged upon and potentially modulated during online operation. The control parameters are employed in real time during periods of offline operation to regulate glucose level without the need for user-provided control parameters such as correction factors and insulin-to-carbohydrate ratios.