Abstract: An aerosol provision cartridge (30) for an aerosol provision system (10). The cartridge (30) comprises a refillable chamber (100) for aerosol precursor material, the chamber (100) comprising a first opening (102) and a second opening (104), each opening (102;104) allowing for access into the chamber (100). Each opening (102;104) is covered by a respective cap (130;132) which is configured to be uncoupled from the chamber (100) for allowing access to the opening (102;104). The cartridge (30) is configured such that each cap (130;132), when coupled to the chamber (100), requires at least two different actions (A1;A2) to be uncoupled from the chamber (100). The first or second action (A1;A2) may each include, but are not limited, to: rotating; pulling; pushing; or unlatching.

Abstract: Provided is a cartridge that may be replaceably coupled to a main body of an aerosol generating device, the cartridge including a mouthpiece having a discharge hole, a liquid storage configured to accommodate an aerosol generating material, and a vibration receiver configured to transfer vibration generated by a vibrator of the main body to the aerosol generating material such that aerosols are generated from the aerosol generating material by the vibration.

Abstract: In some embodiments, a processor-implement method includes receiving a fill completion message including formulation and capsule identifiers from a fill station. The method also includes receiving a registration request including a vaporizer identifier and a compute device or user identifier from a compute device. The registration request is verified, and a registration confirmation message is sent to the compute device. The method also includes receiving a capsule attach event detection message including the capsule identifier, the vaporizer identifier, and at least one of the identifier of the compute device or the identifier of the user. A validity of the capsule attach event detection message is evaluated. If the capsule attach event detection message is valid, an unlock message is sent to the compute device or a vaporizer, and if the capsule attach event detection message is valid, an alert is sent to the compute device or the vaporizer.

Abstract: An aerosol generating device, includes an inhalation outlet; a chamber for holding a material, the material capable of generating a vapour when heated; a heater for heating material held in the chamber; an air inlet connected by an air inlet passage to the chamber; a vapour-cooling module providing a fluidic connection between the chamber and inhalation outlet, the module configured to cool a vapour passing there through. Suction at the inhalation outlet causes air to enter the chamber via the air inlet, thereby transporting vapour generated in the chamber through the module to the inhalation outlet, such that the temperature of the vapour exiting the device through the inhalation outlet is substantially lower than the temperature of the vapour generated in the chamber. The device thereby provides a means whereby a vapour generated in the chamber is substantially cooled during transport from the chamber through the mouthpiece to the user.

Abstract: The subject disclosure relates to a device for smoking and filtering smoke. In an aspect, the device can comprise an outer sleeve component, a detachable mouthpiece assembly, an ignition chamber assembly, and a detachable filtration assembly.

Abstract: The subject disclosure relates to systems, methods, and apparatuses for filtering smoke from a cigarette or other combustible item. In an aspect, the subject disclosure includes employing an inhale chamber comprising a first front portion, a first body portion, and a first rear portion, wherein a cigarette holder element affixed to a rear housing mouth cover of the first rear portion and located within a first hollow cavity portion of the first body portion, and wherein a first valve capable of sealing or unsealing an opening within a first hollow tube portion is located within a second hollow cavity portion of the first rear portion and within the first hollow tube portion that connects the first hollow cavity portion to the second hollow cavity portion.

Abstract: An oral pouch product having a soft edge includes an inner filling material enclosed inwardly of at least one seam between opposed layers of porous pouch wrapper. The at least one seam is separated from the periphery of the porous pouch wrapper by an unbonded area of the opposed layers so as to form a soft edge of the pouch wrapper.

Abstract: The claimed invention is an apparatus to assist and encourage a person to take long, deep and steady breaths. The invention is designed to provide improved health for the user by fostering; improved breathing and relaxation, aroma delivery and positive smell association, calmer clearer thinking, reduced stress and anxiety, as well as providing a substitute for potentially harmful habits such as smoking, over-eating, over-drinking and other forms of drug abuse. This invention may also reduce the impact of some existing physiological and psychological health conditions.

Abstract: The invention provides a method for making a fuel element for a smoking article including the steps of mixing a metal-containing catalyst precursor with a filler material or graphite or a combination thereof to form a pre-treated fuel element component; optionally calcining the pre-treated fuel element component in order to convert the catalyst precursor to a catalytic metal compound; after the optional calcining step, combining the pre-treated fuel element component with a carbonaceous material and a binder to produce a fuel element composition; and forming the fuel element composition into a fuel element adapted for use in a smoking article. Examples of metal-containing catalyst precursors include iron nitrate, copper nitrate, cerium nitrate, cerium ammonium nitrate, manganese nitrate, magnesium nitrate, and zinc nitrate. Fuel elements treated according to the invention, and smoking articles including such fuel elements, are also provided.

Abstract: A device (1) for producing an aerosol from vaporizable constituents of tobacco comprises a vaporizing chamber (24) within which the tobacco is placed. A main housing (9) which forms a portion of the vaporizing chamber also forms a combustion chamber (18) within which a gas catalytic combustion element (19) is located for converting fuel gas to heat by catalytic action. A temperature responsive control valve (61) controls the supply of fuel gas to the combustion chamber for maintaining the temperature in the vaporizing chamber A thermal mass (96) secured to a tab portion (95) of the gas catalytic combustion element maintains the temperature of the tab portion at or above the ignition temperature of the gas catalytic combustion element during periods of fuel gas interruption by the control valve. Vaporised constituents of the tobacco are drawn from the vaporizing chamber through an aerosol accommodating tube (37) through a mouthpiece (38).

Abstract: Tobacco products comprising smokeless tobacco products and active ingredients, including those that antagonize nicotinic acetylcholine receptors, the TRPV1 channel, and/or the TRPA1 channel are disclosed. Nicotine replacement therapies comprising active ingredients, including those that antagonize nicotinic acetylcholine receptors, the TRPV1 channel, and/or the TRPA1 channel. The active ingredient may reduce or eliminate sensory irritation arising due to use of the product. Analgesic compositions comprising active ingredients. Methods of reducing taste and sensory irritation by employing an active ingredient.

Abstract: An electronic cigarette including an atomizer, a cartridge, a mouthpiece, a power switch, and an electronic cigarette refilling apparatus for use therein is disclosed. A method of dispensing a liquid into an electronic cigarette and a method of inhaling a vapor from an electronic cigarette are also disclosed.

Abstract: An aerosol generator device for delivering an aerosol of a nicotine salt is provided. The aerosol generator comprises: (i) a mouth end; (ii) a first chamber containing a porous material wetted with liquid nicotine, (iii) a second chamber containing a porous material wetted with a solution of a volatile acid, (iv) a third chamber in fluid communication with the first and second chambers, leading to the mouth end, and (v) an outer housing defining a passageway for air through said device. A nicotine vapor can be produced by drawing air along the passageway and through the porous material wetted with liquid nicotine. An acid vapor can be produced by passing air along the passageway and through the porous material wetted with a solution of a volatile acid. Then, the nicotine vapor and the acid vapor can be admixed in the third chamber to form an aerosol of a nicotine salt, which can be drawn out through the mouth end.

Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Abstract: A smoking article includes identification information encoded on the smoking article. The smoking article can be used with an electrically heated smoking system having a detector for detecting the smoking article and distinguishing the smoking article from other articles based on the identification information. A cleaning article includes identification information encoded on the cleaning article. The cleaning article cleans an electrically heated smoking system having a detector for detecting the cleaning article and distinguishing the cleaning article from other articles based on the identification information.

Abstract: A smoking article, such as a cigarette, comprises a lighting end and a mouth end. The smoking article possesses an aerosol-generation system that includes (i) a heat generation segment, and (ii) an aerosol-generating region or segment. A mouth end piece segment can be located at the mouth end of the smoking article. A segment of tobacco cut filler, gathered tobacco paper, or other type of flavor source material, can be positioned between the mouth end piece segment and the aerosol-generation segment. Optionally, segment composed of tobacco cut filler can be positioned so as to provide a lighting end segment.

Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Abstract: A device for simulating a chemosensation of smoking includes an outer layer, a porous medium and a chemesthetic agent. The porous medium is disposed within the outer layer. The chemesthetic agent is disposed within the porous medium and activates a TRP channel.

Abstract: An aerosol generator device has an elongate body with an interior passageway extending longitudinally to its mouth end. The device receives an interchangeable, pressurized canister charged with a nicotine containing liquid that is discharged in a metered dose on manual actuation of a button member that causes a valve in the canister to open and discharge through a discharge tube. A sleeve releasably couples the canister to the body. The button member is slidably mounted on the body for reciprocal movement along a trigger axis Y-Y? extending transversely of the longitudinal axis X-X? of the device, and has a manually depressible surface portion and a camming surface portion that drives a slidable nozzle member to press the discharge tube inwardly of the canister to open its valve and release liquid into the nozzle member. Nozzle forms an aerosol from the liquid, which is delivered to the consumer through outlets in the mouth end of the device.

Abstract: A bioactive dose for delivering a bioactive agent to a mammal, includes a solid bioactive dosage unit containing at least one bioactive agent and a rapid release coating provided on at least one outer surface of the solid bioactive dosage unit, the rapid release coating containing a material having a property of rapidly modulating a pH of bodily fluids in which the material comes in contact in a direction towards an ideal absorptive pH or towards an ideal pH to hinder absorption of the at least one bioactive agent given the pKa that least at one bioactive agent.

Abstract: A smokeless pipe comprises a bowl (1), a shank (2), a stem (3) with a bit (4) and an air channel (5) inside of the pipe, which is used for placing a carrier of a nicotine-containing or flavoring agent (10) and a heating unit (7) connected to a power supply (8). According to the invention at least one of elements (7) of a heating unit is arranged in the stem (3) and is shifted to the bit (4). The invention ensures preservation of the health of a pipe smoker while fully simulating the process of smoking.

Abstract: A vaporization lighter flame casing is disclosed. The flame casing can include an attachment portion adapted to attach the flame casing to a lighter. The flame casing can also include a channel adapted to direct a hot air stream rising from a flame of the lighter when the lighter is lit. The flame casing can further include an outlet coupled to the channel through which the hot air stream exits the flame casing, where the outlet extends from the flame casing at an angle relative to the channel.

Abstract: An electronic cigarette includes a shell and a mouthpiece. The external wall of the shell has an air inlet. An atomizer and a liquid-supply are in contact with each other. The air inlet, atomizer, an aerosol passage, and a mouthpiece are sequentially interconnected.

Abstract: A cigarette includes lighting and mouth ends. It may include a smokable segment disposed at the lighting end. It also includes a mouth-end segment; an aerosol-generation system disposed between the lighting and mouth ends, which includes (i) a heat-generation segment adjacent the smokable segment, including a heat source configured to be activated by combustion of a smokable material and an insulation layer of a non-glass material that is woven, knit, or both, and (ii) an aerosol-generating segment with aerosol-forming material disposed between, but physically separate from, each of the heat generation segment and the mouth end; a piece of outer wrapping material that provides an overwrap around at least a portion of the aerosol-generating segment, the heat-generation segment, and at least a portion of the smokable segment; those segments being connected together by the overwrap to provide a cigarette rod; that is connected to the cigarette rod using tipping material.

Abstract: A non-combustion type flavor suction article includes a capsule enclosing a liquid flavor in a shell, leak-protection members sandwiching the capsule, a wrapping material made of a flavor-impermeable and heat-conducting material and wrapped around the capsule and the leak-protection members, and a mouthpiece connected to an end of the wrapping material.

Abstract: An emulation aerosol sucker includes a battery assembly, an atomizer assembly and a cigarette bottle assembly. An external thread electrode is located in one end of battery assembly. An internal thread electrode is located in one end of atomizer assembly. Said battery assembly and said atomizer assembly are connected by the screwthread electrode. Said cigarette bottle assembly is inserted into the other end of said atomizer assembly and both form one cigarette type or cigar type body.

Abstract: A non-combustion flavor inhalation article includes a heating device including a heater to be heated to a temperature between 80 and 140° C., and a roll including a tobacco sheet to be disposed in contact with the heater.

Abstract: An aerosol generator device for delivering an aerosol of a nicotine salt is provided. The aerosol generator comprises: (i) a mouth end; (ii) a first chamber containing a porous material wetted with liquid nicotine, (iii) a second chamber containing a porous material wetted with a solution of a volatile acid, (iv) a third chamber in fluid communication with the first and second chambers, leading to the mouth end, and (v) an outer housing defining a passageway for air through said device. A nicotine vapor can be produced by drawing air along the passageway and through the porous material wetted with liquid nicotine. An acid vapor can be produced by passing air along the passageway and through the porous material wetted with a solution of a volatile acid. Then, the nicotine vapor and the acid vapor can be admixed in the third chamber to form an aerosol of a nicotine salt, which can be drawn out through the mouth end.

Abstract: The present invention generally relates to methods and materials involved in producing tobacco plants having reduced levels of conversion of nicotine to nornicotine. In certain embodiments, the invention is directed to mutations in a nicotine demethylase gene, tobacco plants comprising mutations in a nicotine demethylase gene, and tobacco compositions and products thereof. In other embodiments, the invention is directed toward nicotine demethylase RNA interference, tobacco plants comprising a nicotine demethylase RNA interference transgene, and tobacco compositions and products thereof.

Abstract: A portable vaporization implement, comprising: a tubular section having a hollow interior, an air intake, and an output orifice; a smoking material chamber that is within said hollow interior and that is in fluid contact with said air intake and said output orifice, and is positioned generally in between said air intake and said output orifice, wherein desired components of a smokable substance may be vaporized; and a purely mechanical means for automatically regulating the amount of heat entering said smoking material chamber, whereby the temperature within said smoking material chamber stays within the vaporization range of said smokable substance, wherein said mechanical means allows unimpeded inhalation by the user.

Abstract: The invention relates generally to a system and method for treating conditions responsive to nicotine therapy. More specifically, the invention relates to pulmonary administration of a nicotine containing formulation to effect smoking cessation.

Abstract: The invention relates to a heating device (9), for a mobile inhalation unit for the inhalation of active agents, comprising a heating wire (15), with two connector ends (23, 31) for the introduction of electrical energy and a thermal reservoir (13, 17) for heating air flowing along the thermal reservoir, whereby the thermal reservoir may be heated by means of the heating wire. The heating wire has a temperature coefficient of at least 0.001 K?1. The invention further relates to an inhalation unit with such a heating device and a method for heating a thermal reservoir on such a heating device.

Abstract: The invention relates to a cigarette substitute, comprising a hollow tubular element (1) provided with a generator of products to be inhaled (7, 8), with internal heating means (6) for heating the inspired air or at least part of the generator of products to be inhaled, and with a device (8) for triggering the generator of products to be inhaled. It is characterized in that the triggering device comprises an element (8) sensitive to the heat produced by heating means that are situated outside the substitute (1) and are independent of the latter, said heat-sensitive element (8) being made of a material that cannot ignite or burn under the conditions of normal use of the substitute (1). It is thus possible to activate the cigarette substitute with the aid of a flame, without thereby causing combustion of the generator of products to be inhaled.

Abstract: The invention is directed at the full simulation of a smoking process when a smoker uses the inventive pipe. Said smoking-simulating pipe comprises a shank (1) and a bowl (2) which are embodied in one piece, and a stem (4) which is detachable from the shank (1) and is provided with a bit, wherein a cavity (5), which is used for placing a sealed capsule (6) provided with a nicotine-containing or flavoring agent, is embodied in a smoking channel (14), and an electric heater (7) connected to a power supply (8), which is arranged in the walls of the bowl (2), is located before the capsule (6) in the smoking channel (14).

Abstract: The false luxury item 10 of the present invention is characterized by having an outer package portion 14 being the same as or similar to an outer package portion 16 of a marketed luxury item 15 including a tobacco or an alcohol beverage such as beer and the outer package portion 14 has a false content 13 being different from that of the marketed luxury item 15 or a content being the same as the content of the marketed luxury item 15 in such a state not allowing the intake. A user repeats one set of actions that the user recognizes the false luxury item and pretends to drink alcohol either halfway or entirely, but actually does not drink alcohol or smoke tobacco and, as a result, conditional reflexes appeared at an early stage are reduced gradually and a desire for alcohol or tobacco does not occur finally, whereby abstention from alcohol and/or tobacco can be promoted.

Abstract: The present invention relates to an aerosol spray device (10, 20, 30, 40) for administration of a substance, specifically a substance having a disagreeable taste, such as nicotine, to the oral cavity of a subject; to an actuator (16, 26, 36, 46) included in said spray device and to methods for delivering the substance.

Abstract: A system and method for a cigarette smoke filtration device that reduces second-hand smoke and holds a lit cigarette while being smoked or sitting idle. The device somewhat resembles a bifurcated cigarette holder wherein a lit cigarette is placed within the device while being smoked or sitting idle. Once inside, the device draws the smoke from the cigarette through a filtering system reducing offending odors as well as most of the harmful gases from cigarette smoke. The filtering system has replaceable filter cartridges. The spent ashes are collected in the device's base which can be emptied as needed.

Abstract: A carbonaceous heat source composition for a non-combustion-type smoking article contains calcium carbonate in an amount of 30 to 55% by weight.

Abstract: A device which facilitates the absorption of nicotine in order to reduce the incidence of tobacco smoking is disclosed. The device includes a tube defining an interior space. The tube has a first end with an opening and a second end. An inhalable, flowable liquid or gel composition is disposed in the interior space of the tube. The composition may include water, at least one vitamin, a flavoring agent, and nicotine. The flavoring agent may include an intense sweetener such as sucralose, and a natural or artificial fruit flavor. A user inhales on the first end of the tube of the device as a substitute oral activity to tobacco smoking and thereby ingests a source of nicotine that reduces the withdrawal symptoms experienced when smoking is stopped.

Abstract: In an apparatus for water-pipe smoking, a liquid container and a bowl unit are disposed in a hollow base. The liquid container includes a container body to be partially filled with a liquid body, a smoke guide duct having first and second duct portions that respectively extend out of and into the container body, and a smoke passage accessible via a radial access hole in the hollow base. The bowl unit is coupled to the first duct portion, holds combustible smoking material therein, and allows smoke that results from combustion of the smoking material in the bowl unit to flow into the smoke guide duct. An electric heating unit is mounted to a top cover that covers a top side of the hollow base, and is operable so as to generate heat for causing the smoking material in the bowl unit to combust.

Abstract: A vaporizer device that uses a flame for vaporizing flavor and psychoactive compounds from smoking materials such as tobacco. The present device has a filter unit 34 with a porous flame filter 36. The flame filter 36 can be made of open-cell ceramic or metal foam, sintered ceramic or metal granules or other porous, heat resistant materials. In use, flame is supplied to the flame filter, and inhalation causes ambient air to enter the flame filter as well. The flame exhaust and ambient air are mixed within the flame filter and produce an air stream of intermediate temperature. The intermediate temperature air stream is hot enough to vaporize desirable components from the smoking material, but generally is not hot enough to burn the smoking material. The temperature of the air stream can be controlled by adjusting the amount of flame supplied to the flame filter 36.

Abstract: There is provided an aerosol generating apparatus which is capable of generating aerosol stably. The aerosol generating apparatus includes a container which mixes a particulate material and a carrier gas to generate a fluidized bed of the particulate material; an aerosol delivery tube which sucks a part of the fluidized bed to deliver the part as an aerosol containing the particulate material and the carrier gas; an optical sensor which measures a position of the fluidized bed; and an adjusting unit which adjusts the position of the aerosol delivery tube based on an information about the position of the fluidized bed measured by the optical sensor. By moving an end of the aerosol delivery tube horizontally along and relative to the top surface of the fluidized bed, it is possible to avoid harmful effect that particle size distribution in the fluidized bed becomes locally non-uniform.

Abstract: The Sensory Smoking Simulator (5) performs by means of suction to draw smoke (33) from a cigarette (21a), only a small amount of which is smelled by the user (39). It is a main body (40) that includes an air motor (12) and a vacuum pump impellers (29) operating in two separate sections (41 and 42). The lower section (42) has a window (10) to connect with the ambient air and a mouthpiece (15) that yields a bitter taste. Means is provided so that when a person (39) inhales, air is draw into the lower section (42) and through the mouthpiece (15). The upper section chamber (41) has a cigarette receiver (24) and two passageways attached, one of them (35) to exhaust the cigarette smoke to ambient air, the other one (30) to let exhaust a lesser amount of smoke (33s) near the user's nose (31). The smell from cigarette smoke (33s) and the taste secreted from the mouthpiece (15) create a mental effect similar to that of smoking, but far less harmful to a person's health.

Abstract: A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aerosolizing a formulation and containers of formulation. The formulation is comprised of nicotine in a pharmaceutically acceptable carrier. Preferably, a plurality of containers are produced wherein the concentration of nicotine in the different containers or different groups of containers is reduced. The patient uses containers with the highest concentration initially and gradually moves towards using containers with lower and lower concentrations of nicotine until the patient's dependence on nicotine is eliminated.

Abstract: The Sensory Smoking Simulator (5) performs by means of suction to draw smoke (33) from a cigarette (21a), only a small amount of which is smelled by the user (39). It is a main body (40) that includes an air motor (12) and a vacuum pump (29) operating in two separate sections (41 and 42). The lower section (42) has a window (10) to connect with the ambient air and a mouthpiece (15) that yields a bitter taste. Means is provided so that when a person (39) inhales, air is drawn into the lower section (42) and through the mouthpiece (15).

Abstract: A coated chewing gum product for the delivering of nicotine in any form to a subject by a rapid transmucosal uptake in the oral cavity comprising at least one gum core, nicotine in any form and/or a nicotine mimicking agent, at least one coating layer and optionally at least one or more other additive, wherein said at last one coating layer is buffered. Also contemplated is a method for the delivering of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as a method for producing said coated chewing gum and the use of the same form obtaining a quick transmucosal uptake of the nicotine in the oral cavity of a subject.

Abstract: A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aerosolizing a formulation and containers of formulation. The formulation is comprised of nicotine in a pharmaceutically acceptable carrier. Preferably, a plurality of containers are produced wherein the concentration of nicotine in the different containers or different groups of containers is reduced. The patient uses containers with the highest concentration initially and gradually moves towards using containers with lower and lower concentrations of nicotine until the patient's dependence on nicotine is eliminated.

Abstract: The present invention relates to a container comprising nicotine to be inhaled, which is able to retain and release nicotine, and which comprises a shaped mass of fibers and/or filaments. Further, the present invention relates to the use of said container in an inhaling device for obtaining a quick and/or complete reduction of the urge to smoke or use of tobacco and/or for providing a sense of smoking satisfaction without smoking and to the use of said container in smoking cessation therapy.

Abstract: Salts formed from nicotine and anion-forming sweeteners, for example acesulfame or acesulfame-K, in a molar ratio of 1:1 or 1:2, in which case the sweetener molecules can be identical or different, are distinguished by a pleasant sweet taste which masks the nicotine taste even after a long residence time in the mouth, and are therefore suitable for producing preparations, in particular chewing gum, chewing tablets or compressed compositions, which can be used for oral administration of nicotine, for example in withdrawal from smoking.

Abstract: The present invention relates to an aerosol spray device (10, 20, 30, 40) for administration of a substance, specifically a substance having a disagreeable taste, such as nicotine, to the oral cavity of a subject; to an actuator (16, 26, 36, 46) included in said spray device and to methods for delivering the substance.