Abstract: A system is disclosed which makes it possible for a patient to be delivered gradually reduced amounts of nicotine over time thereby allowing the patient to be gradually weaned off of dependence on nicotine and quit smoking. The system is comprised of a means for aerosolizing a formulation and containers of formulation. The formulation is comprised of nicotine in a pharmaceutically acceptable carrier. Preferably, a plurality of containers are produced wherein the concentration of nicotine in the different containers or different groups of containers is reduced. The patient uses containers with the highest concentration initially and gradually moves towards using containers with lower and lower concentrations of nicotine until the patient's dependence on nicotine is eliminated.

Abstract: The nicotine addiction associated with smoking can be reduced by a combination of nutrition augmentation, craving reduction, and therapy. The craving reduction is accomplished by administration of corticotrophins and mild relaxants, for example, tryptophan and GABA precursors.

Abstract: The present invention is directed to an oral nicotine delivery device and a method of using the device to reduce the incidence of tobacco smoking in a person. The device comprises a tubular chamber having a first end suitable for taking in liquid or gas from an external source and a second end suitable for the application of oral suction. The chamber contains nicotine and a retainer for preventing release of the nicotine from the first end of the chamber. The device delivers nicotine in non-irritating solution form.

Abstract: The present invention involves a system and method for a user of smokeless tobacco to reduce the deleterious effects to oral tissues from the chemicals generated from using smokeless tobacco. A protective shield encloses a quantity of tobacco while resting in a mouth of a user, generally between the cheek and gum surfaces. The protective shield may be impermeable, sanitary, and disposable or biodegradable. It may assist in reducing leukoplakia and other oral diseases related to the use of smokeless tobacco. It attempts to allow the normal use of smokeless tobacco without interfering with speech, drinking, and other activities while providing some protection from the chemicals. The present invention involves a system and includes a container for holding the shields, having an opening for removing the shields for convenience and to encourage use, typically in the vicinity to a quantity of smokeless tobacco for easy access.

Abstract: For the continuous production of the cigarette rod (10), the strip-like outer wrapper (12) and a tobacco strand (11) are provided on a forming belt (15) and conveyed, with the latter, through a rod-forming unit (13). Located within the latter is a forming bed (19) which, during transportation, deforms the forming belt (15) along with the outer wrapper (12) and the tobacco rod (11) so as to produce a cigarette rod (10). A compensating belt (21) is provided in order to avoid or reduce the friction of the forming belt on the forming bed (19), and said compensating belt circulates at reduced speed between the forming belt (15) and forming bed (19) The compensating belt (21) reduces the friction and dissipates (frictional) heat.

Abstract: A method of rolling cigarette portions, wherein a first succession of first pairs of cigarette portions and a second succession of second pairs of cigarette portions are advanced in a direction crosswise to the respective axes of the cigarette portions, each first pair being defined by a first and a second cigarette portion coaxial with and a given distance from each other, the second succession being parallel to the first succession, and each second pair being defined by a third and a fourth cigarette portion coaxial with and the aforementioned distance from each other; the first pairs and the second pairs are partially engaged combfashion in a relative position in which each third cigarette portion is partially inserted between two adjacent second cigarette portions; a double filter and a respective projecting band are inserted between the first and second cigarette portions and between the third and fourth cigarette portions to form respective groups; and the groups, arranged in the first and second succes

Abstract: A nicotine candy is provided for consumption in small volumes and in a cigarette shaped package. Each portion of the candy is obtained by removing it from a cigarette shaped package from the end. In a first embodiment, standard paper is used to wrap the a series of linearly disposed candy portions. In a second embodiment, the package is made of edible rice paper, and may be torn off of the end in a single piece. The formulation of the candy preferably uses a food grade Beta-pyridyl-alpha-N-methylpyrrolidine dissolved into any standard hard sugar candy. This material is water soluble and is admixed into the sugar candy composition during candy formation. Preferably, the candy composition is available in a range of strengths which further enables users to regulate their doses. One or two or three pieces can be ingested simultaneously to enable control of the intake, in addition to the availability of the composition in different strengths.

Abstract: A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or its other agonist in an amount sufficient to at least partially block the pharmacologic defects of the drug or its other agonist while there is a substantial amount of the drug or other agonist present in the system of the user. In one embodiment of the invention, the drug and the antagonist are administered substantially simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or other agonist.

Abstract: A filter assembly machine wherein a succession of tobacco articles, each defined by at least one cigarette portion aligned with a respective filter, and a succession of respective gummed strips are fed by a conveyor drum to a first and a second rolling wheel rotating about respective axes and having a number of peripheral axial cavities, each of which houses a respective roller defining, with the cavity, a rolling channel; the tobacco articles, once rolled to connect the cigarette portions and filters by means of respective strips, are transferred from the first and second rolling wheel to an output drum by means of conveyors having seats on the end of respective ribs engageable between pairs of adjacent rollers.

Abstract: A cigar substitute, comprising an elongate, inedible, flexible tube having a length such that when one end is held in the mouth, the other end protrudes out of the mouth and having at least one lumen containing a mixture comprising nicotine, nicotine derivative, nicotine substitute or nicotine substitute derivative, an edible carrier, and a flavoring substance.

Abstract: A smoking article is provided in which a replaceable tobacco flavor unit containing tobacco flavor material is electrically heated by a set of permanent reusable heaters to evolve flavors or other components in vapor or aerosol form for delivery to a smoker. Each heater heats only a portion of the available tobacco flavor material so that a plurality of individual puffs of tobacco flavor substance can be delivered sequentially to the smoker. The replaceable tobacco flavor unit can also include a filter to reduce the effect of residual aerosol which settles or condenses on the permanent portions of the article and which can result in undesirable flavor generation when reheated. A method and apparatus for manufacturing the replaceable tobacco flavor unit is also provided.

Abstract: A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or its other agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or its other agonist while there is a substantial amount of the drug or other agonist present in the system of the user. In one embodiment of the invention, the drug and the antagonist are administered substantially, simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or other agonist.

Abstract: Effective concentrations of nicotine, of a stimulant, and of a sequestering agent are admixed in a liquid carrier. The sequestering agent prevents binding of nicotine with metallic ions which interfere with absorption of nicotine through the lining of the oral cavity. The liquid solution is sprayed into the oral cavity for simultaneous absorption of the nicotine and stimulant through the lining of the oral cavity.

Abstract: A nicotine oral delivery device, which includes a hollow housing (10) and a hollow mouthpiece (14) which may be detachable connected to the housing (10) or may form with the housing a single piece. The mouthpiece includes a nicotine-containing material (16), in the form of a gel, on one or more of the outer surfaces of the mouthpiece. The housing (10) may also include flavoring (20), such as menthol. The nicotine-containing material (16) may be located as a layer on the mouthpiece (14), or in holes in the mouthpiece or under a permeable membrane (18) covering a portion of the mouthpiece (14). Where the mouthpiece and housing are separate pieces, the mouthpiece may be disposable while the housing reusable.

Abstract: A method for delivering dry powder particles through the mouth of a user, in which a suction is created through an opening in a proximal end of an elongated housing for drawing air into a flow path in the housing from an opening in a distal end of the housing, the distal end including an opening in the housing with a ridge surrounding the housing, and through a resistance member in the housing for introducing a controlled pressure drop in the housing and a resistance to the drawing of air into the mouth of the user.

Abstract: A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or its other agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or its other agonist. In one embodiment of the invention, the drug and the antagonist are administered substantially simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or other agonist.

Abstract: Adherent uniting bands are wound around adjacent end portions of successive groups of plain cigarettes and filter mouthpieces having elliptical cross-sectional outlines while the groups are transported sideways through a passage between a rotary conveyor and a stationary rolling member. The peripheral rolling surface of the conveyor has an undulate profile conforming to the outlines of the articles forming the groups and such surface is provided with axially parallel flutes wherein the groups are received during advancement toward the passage. The rolling member has a second rolling surface confronting the peripheral rolling surface across the passage and having a second undulate profile also conforming to the outlines of the articles forming the groups. Successive groups approaching the inlet of the passage are caused to leave their flutes and to roll between the two surfaces during advancement through the passage to thus convolute the uniting bands around the adjacent end portions of the respecive articles.

Abstract: A method of treating and reducing a drug dependency such as a nicotine dependency is provided. The method comprises initially administering to a subject a drug, such as nicotine or another agonist of the drug in an amount which would normally provide the desired pharmacologic effects and at least partially satiate the needs for the drug by a user. The method also comprises administering to the subject an antagonist to the drug or its other agonist in an amount sufficient to at least partially block the pharmacologic effects of the drug or its other agonist while there is a substantial amount of the drug or other agonist present in the system of the user. In one embodiment of the invention, the drug and the antagonist are administered substantially simultaneously so as to occupy a substantial portion of the receptors of the user for that drug thereby blocking or attenuating the effects of any further intake of the drug or other agonist.

Abstract: The present invention relates to a nicotine-impermeable container and a method for fabricating same. Additionally, the invention relates to a nicotine inhaling device which allows a user to ingest nicotine vapors orally. The nicotine inhaling device of the present invention is primarily directed to a device which can be used as a smoking cessation aid.

Abstract: Chewing gum which is a substitute for tobacco smoke, formed into three 3 g strips, characterized in that each strip contains not more than 25 wt % of a gum base and not more than 0.4 mg of nicotine dispersed in the gum base. The invention provides a nicotine-containing gum which simulates cigarette smoking (by providing a level of nicotine retention in the blood and saliva very similar in intensity and duration to that due to cigarette smoking), without accompanying problems with respect to unpleasant taste, poor chewing characteristics and undesirable side-effects.

Abstract: A dry powder delivery system having an elongaged tube containing a matrix having a measured amount of dry particles of therapeutic compound and a porous element having a dessicant therein is disclosed. The porous element with the dessicant can be combined with the powder-containing matrix or the they can be two separate elements. The pressure drop induced by inhalation by the user causes air to flow through the tube and into contact with the particles of dry powder for discharging the particles for inhalation by the user.

Abstract: A smoking system is provided in which a replaceable cigarette containing tobacco flavor material is electrically heated by a set of electrical heater elements contained within a lighter to evolve tobacco flavors or other components in vapor or aerosol form for delivery to a smoker. The cigarette and lighter are adapted to provide air flow patterns through the smoking system such that air flows transversely into the cigarette. Such patterns improve aerosol and flavor delivery to the smoker and reduce the condensation of residual heater-region vapor/aerosol in the smoking system.

Abstract: An oral pouch that is constructed of an orally safe natural rubber material that can be packed with any brand or flavor of loose moist snuff, by the individual user. The pouch is sized using scissors for maximum comfort and fit, and once inserted between the lower gum and lip, serves as a barrier between the tobacco product and the lip and gum area, therefore reducing the direct physical contact of the tobacco product against the gum and lip. Because the pouch is perforated, saliva flows through the pouch moistening the tobacco, creating the tobacco juice.

Abstract: A control device for electrically heated flavor generators. Sensors detect user lip activity associated with taking a draw and trigger heating of flavor-generating materials.

Abstract: A smoking article includes a combustible fuel element circumscribed by a heat transfer tube with a flavor source material circumscribing the heat transfer tube. At the ignition or upstream end of the smoking article, an impervious annular flange is provided. The flange includes an opening therein substantially the same diameter and configuration as the inside diameter of the heat transfer tube and the outside diameter is substantially the same as that of the smoking article. The flavor source material is in flow communication with the downstream or the mouth end of the smoking article so that upon ignition of the combustible fuel element, smoke that is generated from the fuel element is prevented by the annular flange from coming into contact with the varporizing flavor being released by the flavor source material when the smoker draws on the smoking article. Only the vaporizing materials from the flavor source material is received by the smoker.

Abstract: A cigarette substitute of the present invention is disclosed which provides an edible portion having a small amount of a nicotine composition sufficient to satisfy the desires of the cigarette smoker. The edible portion should preferably be in the shape and size of a familiar object, thereby reinforcing an already familiar form of behavior, while supplying the ingredient which would appease the individual's need for nicotine. Preferably, the edible portion of the present invention would be shaped in the form of a conventional lollypop which would preferably have a hard semi-hard candy. Optionally, the edible portion of the invention would be pleasantly flavored in an assortment of fruit choices in either a sugar or sugar-based substitute. Alternatively, the edible portion of the invention in a mint which could provide a taste which is somewhat analogous to that of menthol.

Abstract: A cigarette provides tobacco flavor by heating tobacco, but not burning tobacco or any other material. A heat source which includes a metal oxide (e.g., calcium oxide), an anhydrous metal sulfate (e.g., magnesium sulfate), an inorganic salt and a sugar, generates heat upon contact of water therewith. The heat produced by the heat source heats tobacco in a heat exchange relationship therewith. Flavors volatilize from the tobacco and are drawn into the mouth of the user of the cigarette. Typical heat sources heat the tobacco to a temperature within 70.degree. C. to 200.degree. C. for 4 to 8 minutes.

Abstract: A method and a composition for aiding in the reduction of the incidence of tobacco smoking which comprises a method of administering a nicotine containing aerosol spray to the oral cavity of an individual to provide a stimulation to the respiratory tract of the smoker, somewhat similar to that provided by normal tobacco smoke. The method also comprises a composition of a low concentration nicotine aerosol spray in which the spray droplets have a size and a range of between about one micron to about ten microns in diameter and which spray preferably contains nicotine in an amount of about 0.005 miligrams to about 0.03 miligrams per inhilation.

Abstract: A simulated smoking device includes a hollow tube with a capsule of pressurized aerosol generating material located inside the tube. An air flow passage is defined between the capsule and tube wall. The capsule includes an aerosol outlet port having a valve for selectively opening and closing the outlet port. An air operated valve activator is located inside the tube downstream of the air flow passage and is operatively connected to the valve. An aerosol passage communicates with the aerosol outlet port of the capsule and has a discharge end downstream of the air passage. Air is drawn into the tube, passes through the air passages, and impacts the air operated valve activator causing the valve to move opening the aerosol outlet port of the capsule releasing aerosol into the air flow downstream of the air operated valve activator.

Abstract: An aerosol delivery article provides flavor or a dose of a drug by heating a flavor or a drug, but not burning any material. A heat source which includes granular magnesium, granular iron, and finely divided cellulose generates heat upon contact thereof with an aqueous solution of potassium chloride. The heat source is in a heat exchange relationship with the flavor or drug. Heat generated by the heat source heats the flavor or drug in a controlled manner. The flavor or drug volatilizes and is drawn into the mouth of the user of the article. Typical heat sources heat the flavor or drug to a temperature within about 70.degree. C. to about 180.degree. C. for 4 to 8 minutes.

Abstract: A cigarette provides tobacco flavor by heating tobacco, but not burning tobacco or any other material. A heat source which includes granular magnesium, granular iron, and finely divided cellulose generates heat upon contact thereof with an aqueous solution of potassium chloride. The heat source is in a heat exchange relationship with the tobacco. Heat generated by the heat source heats tobacco in a controlled manner. Flavors volatilize from the tobacco and are drawn from the cigarette and into the mouth of the smoker. Typical heat sources heat the tobacco to a temperature within about 70.degree. C. to about 180.degree. C. for 4 to 8 minutes.

Abstract: Compositions comprising nicotine and a volatile nicotine-miscible substance may be used to create sources of modulated nicotine vapor. The modulation of nicotine vapor may be one of quantity or of perceived physiological impact or a combination of both. The substance should have a volatility somewhat similar to that of nicotine and have a normal boiling point between about 175.degree. C. and about 275.degree. C. These compositions may be placed in the nicotine reservoir of a personal oral nicotine inhaler. Esters are preferred nicotine miscible substances, particularly when substantially flavorless and generally recognized as safe for human consumption. Nicotine and nicotine-miscible substance in a weight/weight ratio between about 0.5 and 40.0 are emplaced in a nicotine reservoir, for example absorbed in a porous polyethylene item, for insertion into the tubular passageway of a smokeless cigarette.

Abstract: Apparatus for adjusting a cigarette having a variable smoking characteristic to a preselected level of that characteristic is provided. A cigarette having a rotatable element for controlling a smoking characteristic, and assembled with a first level of that characteristic, is adjusted to a preselected second level by a drum and cooperating belt which engage the rotatable element and which move relatively faster and slower, or slower and faster, respectively, than a drum and belt holding the remainder of the cigarette.

Abstract: Filter cigarettes which are transported sideways at the periphery of a rotating drum-shaped conveyor are engaged by successive rolling surfaces of a pair of coaxial rotary rolling members which rotate at the peripheral speed of the conveyor but in the opposite direction so that the cigarettes are caused to roll about their respective axes and cease to advance with the conveyor. The periphery of the conveyor is formed with flutes which receive the freshly rolled cigarettes, and the rolling of cigarettes is abruptly terminated by arresting members which orbit adjacent the path of movement of the cigarettes at the peripheral speed of the conveyor and in the same direction. A laser is used to make holes in successive cigarettes while the cigarettes roll about their respective axes.

Abstract: This invention provides a process for the inclusion of a solid particulate component into self-propelled aerosol formulations of inhalable nicotine.

Abstract: A device for inhaling a mixture of air and vaporized volatile compounds, but without combustion or thermal decomposition of the volatile compounds or of other non-volatile organic matter, as is the case in ordinary smoking methods. The device is intended to be hand-held in a manner similar to that of an ordinary tobacco pipe. It can be used further to administer volatile medications, by route of the respiratory organs, to the bodily system of the user of the device. The device is intended to not achieve uncomfortable surface temperatures while at the same time it will be able to readily and rapidly evaporate compounds and mixtures of such compounds that can achieve a vapor pressure of one atmosphere at temperatures of less than 250.degree. C.