Abstract: A transfer system suitable for medicaments comprising a vial socket, a housing having first and second open ends with the first open end being releasably connected to the vial socket, a needle hub mounted within the housing, a needle having first and second piercing ends mounted in the needle hub, a vial having a neck and a body, the vial being inserted in the vial socket and being non removably retained therein, a cartridge having a plunger sealing an open end thereof and a septum located at an opposite end of the cartridge, and an activation cap for causing the needle to penetrate a septum of the vial and the septum of the cartridge to permit transfer of components therebetween.

Abstract: A medical liquid filling system and associated methods are provided, the system comprising a disposable and a drive system. The disposable includes a tubular member and a piston slidably disposed within the tubular member for retraction and advancement within at least a first portion of the tubular member. The disposable may include a seal member for sealing the first portion of the tubular member and may be interconnected to the piston for co-movement therewith. The drive system may include a piston drive member selectively interconnectable to the piston for driven advancement and retraction of the piston within the tubular member. The drive system may be interconnected to a controller, which may be operable to automate or semi-automate various filling operations. A user interface may be interconnected to the controller for providing input of various system operation parameters, which may be communicated to the controller to facilitate automated or semi-automated operation of the filling system.

Abstract: A spray system for dispensing a homogenous mixture of a liquid formulation and propellant as an atomized aerosol where a disposable container containing a liquid base is used alone or secured within a rigid container and is charged through a fitting in fluid communication with the interior of the disposable container using a detachable pressurized charge can containing a propellant compatible with the liquid base. Preferably the liquid formulation is a paint base that can be tinted at the point of sale before charging with the charge can.

Abstract: Some embodiments disclosed herein related to a device for transferring precise amounts of fluid from at least one source container to a at least one target container. In some embodiments, the fluid is first transferred from the source container (e.g., a vial) through a connector to an intermediate measuring container (e.g., a syringe). In some embodiments air can pass through an air inlet and enter the vial to compensate for the volume of fluid withdrawn from the vial. An air check valve or a bag or a filter can prevent the fluid from escaping through the air inlet. The precisely measured amount of fluid can then be transferred from the intermediate measuring container to the target container (e.g., an IV bag). In some embodiments the connector can include a source check valve and a target check valve to direct fluid first from the source container to the intermediate measuring container and then from the intermediate measuring container to the target container.

Abstract: A system (10) and method for accurately delivering controlled amounts of viscous fluid to one or more fluid delivery devices (31). There is a fluid reservoir (12), a variable-volume fill chamber (18), and structure (171, 173) that fluidly interconnects the reservoir (12) to the fill chamber (18). Valving (22) is used to channel fluid flow from the reservoir (12) to the fill chamber (18). There is a device (20) that dispenses fluid from the fill chamber (18). Valving (24) is used to channel fluid flow from the fill chamber (18) to a fluid delivery device (31). A controller (28) automatically controls operation of the device (20) that dispenses fluid from the fill chamber (18), and may also control operation of the valving (22, 24).

Abstract: An automated system (100) for compounding pharmaceutical agents for injection treatment of a patient includes a housing (110) enclosing an interior space; an inventory structure (130) having a plurality of chambers (131) for individually holding one or more pharmaceutical agent—containing single use capsules (102), wherein each capsule has a volume capacity of from about 0.1 to about 10.0 mL liquid; means (140) for selecting capsules in accordance with predetermined pharmaceutical agents contained in said capsules; means (150) for moving the selected capsules to a processing area; means (165,166) for sequentially transferring a controlled quantity of the predetermined pharmaceutical agent with direct fluid communication from each selected capsule to a product container under positive or negative pressure; and means (151) for automatically discarding spent capsules from which the pharmaceutical agents have been removed after a single use.

Abstract: An adapter assembly for establishing bidirectional fluid connection between a cartridge and a vial includes a housing having an open first end adapted to engage the cartridge and a second open end adapted to engage the vial. The adapter includes a needle assembly having a first tip and a second tip, with the needle assembly disposed within the housing and at least partially supported by a needle holder. The needle assembly is movable relative to the housing from an initial position in which the first and second tip are isolated from the cartridge and vial, to an end of use position, in which first tip is engaged with the vial and the second tip is engaged with the cartridge, establishing fluid communication therebetween. The needle assembly is maintained in the initial position by a locking structure which is released by rotationally advancing the needle holder relative to the housing.

Abstract: Inline liquid drug medical device having a longitudinal device axis, a housing with a linear displaceable sliding flow control member displaceable along a transverse bore from a first flow control position for establishing flow communication between a first pair of ports for liquid drug reconstitution purposes to a second flow control position for establishing flow communication between a second pair of ports for liquid drug administration purposes, and a manually operated actuating mechanism for applying a linear displacement force for urging the flow control member to slide along the bore from its first flow control position to its second flow control position.

Abstract: A liquid extraction apparatus and a method of extracting a liquid from a container and storing the liquid are disclosed. The method includes inserting a liquid extraction member into a container and creating a pressure differential to cause the liquid to flow into a storage vessel.

Abstract: An apparatus for transferring a chosen quantity of medication from a vial to a container under sterile conditions is described. The present invention further facilitates dissolving solid medications contained in the vial or diluting concentrated medications contained in the vial, and transferring the resulting solutions to the container. The container may be an intravenous infuser.

Abstract: An apparatus for filling drug containers such as syringes, and related filling methods, are disclosed. The apparatus uses a removable pumping syringe mounted to the apparatus and located intermediate between the bulk source of drug and the container (e.g. syringe) to be filled such that the drug is first pumped into the pumping syringe and then pumped into the container (e.g. syringe). Actuation of the intermediate pumping syringe is effected with a linear actuator such as a step motor which is engaged to the plunger of the pumping syringe. The linear actuator is controlled by a controller which typically allows different filling and calibrating procedures.

Abstract: A reagent preparation and dispensing device includes a body having a reaction chamber for a reagent and a solution reservoir for a solution. The solution reservoir is isolated from the reaction chamber. A plunger is movably coupled with the body. Movement of the plunger from a starting position to a seated position pushes the solution into the reaction chamber. A dispensing path extends from the reaction chamber out of the body. The dispensing path is configured to dispense a reagent mixture formed from the solution and the reagent. A vent path extends from the reaction chamber, the vent path vents reaction chamber gas displaced by the addition of the solution to the reaction chamber throughout movement of the plunger from the starting position to the seated position.

Abstract: The present invention relates to a medical device comprising a base member (2), a container (20) comprising a container interior (28) adapted to accommodate a substance, and a container closure (23) for fluidly sealing the container interior, and fluid connection means (50) for establishing fluid connection to the container interior. A cover (4) removably mountable on a cover receiving portion (36) is operatively coupled with the fluid connection means (50) to cause a relative motion between the fluid connection means (50) and the container closure (23) in response to a relative motion between the cover (4) and the base member (2).

Abstract: A machine for the preparation of pharmaceutical products is provided with a gripping and carrier device to transfer at least one container between a magazine and a dosage station for the preparation of a pharmaceutical product, and a box-type holding frame defining a chamber for the housing of magazine, gripping and carrier device, and dosage station; the chamber displaying an access aperture to magazine and being crossed by a sterile air flow adapted to avoid the entry of air from the external environment through aperture itself.

Abstract: Systems and methods are provided for filling syringes, e.g., for use during pneumatic retinopexy or other medical procedures. In one embodiment, the system includes a housing carrying a gas canister including an outlet communicating with a fluid path extending from the outlet to a syringe cavity. A syringe includes a barrel receivable in the syringe cavity such that a port of the barrel communicates with the fluid path. An actuator is provided on the housing for selectively opening the outlet of the gas canister to deliver gas therein along the fluid path into the interior of the barrel, thereby causing the plunger to move from a distal position to a proximal position.

Abstract: A medicine mixing apparatus transfusing a medicine using a syringe includes a medicine cassette holding a medicine container, a lifting unit moving the medicine cassette upward and downward to a middle position or a lower position of a main body while maintaining a horizontal attitude of the medicine cassette, a first holding portion held by the main body, and a second driving unit which drives a plunger of the syringe held by the first holding portion to transfuse the medicine.

Abstract: A coinfusion apparatus including a coinfusion operation section; a coinfusion processing room; a supply section; and a transfusion bag retention section. The coinfusion operation section consists of first and second robot arms. The first robot arm retains a medical agent container. The second robot arm performs an operation to insert a syringe needle of a syringe to a mouth section of the medical agent container and an operation to insert the syringe needle of the syringe to a coinfusion mouth of the transfusion bag. The coinfusion processing room holds the coinfusion operation section. The supply section supplies the medical agent container and the syringe into the coinfusion processing room. The transfusion bag retention section retains the transfusion bag at the outer side of the coinfusion processing room and positions the coinfusion mouth of the transfusion bag at the coinfusion communication mouth formed in the coinfusion processing room.

Abstract: A cartridge syringe has a housing with an opening for inserting a cartridge having an cylinder filled with a medication and closed at its ends by a piercing membrane and a stopper having a blind hole. A ram is provided for pressing the stopper for injecting the medication in the cylinder after piercing the membrane. The ram has an actuating element and can be attached in the blind hole for aspiration. The ram has an outer sleeve with a core. The outer sleeve is displaceably guided in a rotatable manner and the core in a rotationally fixed manner. A front end of the outer sleeve is provided with at least one fixing hook which is spring-loaded inwardly. A cam is engageable with the fixing hook such that, upon rotation of the outer sleeve, the fixing hook is movable either to the fixing position or the unlocked position.

Abstract: A system for the closed transfer of fluids that provides substantially leak-proof sealing and pressure equalization during engagement of a cannula with a vial, during transfer of a substance from a vial chamber to a barrel chamber via the cannula, and during disengagement of the cannula from the vial is disclosed. The leak-proof sealing of the system substantially prevents leakage of both air and liquid during use of the system. The system of the present disclosure also permits pressure equalization between a vial and the system when the system is attached to the vial. The system is compatible with a needle and syringe assembly for accessing a medication contained within a vial for administering the medication to a patient.

Abstract: Systems and apparatus for providing fluid communications are described. In an example, a vial access cap includes a connector having an opening for providing access to a fluid pathway; a canella extending into an interior of a vial, the canella having a fluid lumen operatively coupled to the fluid pathway and a gas lumen; and a gravity-assisted valve comprising a valve body defining an elongated valve cavity, a first port, a second port operatively coupled to the gas lumen, and a valve member movable between a sealable end of the elongated valve cavity proximal to the first port and a non-sealable end of the elongated valve cavity proximal to the second port. In other examples, a syringe including a gravity-assisted valve and a system including gravity-assisted valves are described.

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough.

Abstract: A machine for the automatic preparation of an intravenous medication is provided. In one implementation the machine has a chamber with a starting products area where at least one receptacle is disposed with a base product from which the intravenous medication is generated, a transfer tools area where at least one transfer tool that is used to prepare the required medication is disposed, a prepared products area where at least one container to house the prepared medication is disposed, and a first robot to handle the transfer tool, the first robot being adapted to transport the transfer tool between the transfer tools area, the starting products area and the prepared products area in order to prepare the intravenous medication.

Abstract: An automated syringe filler is disclosed comprising a housing and motor with a rotatable syringe holder plate that can be raised and lowered onto exposed syringe needles. The housing also has components for one or more syringes to be attached with the needles pointing upward and the syringe plungers moveably positioned at the bottom. The syringe plunger tool controls the movement of the syringe plunger and can be horizontally and vertically positionable. The syringe plunger tool is motorized and can be controlled by a CPU or similar device containing programmable media.

Abstract: A machine for the preparation of pharmaceutical products is provided with a gripping and carrier device to transfer at least one container between a magazine and a dosage station for the preparation of a pharmaceutical product, and a box-type holding frame defining a chamber for the housing of magazine, gripping and carrier device, and dosage station; the chamber displaying an access aperture to magazine and being crossed by a sterile air flow adapted to avoid the entry of air from the external environment through aperture itself.

Abstract: The invention relates to a transportable therapeutic cartridge, a therapeutic agent robotic mixer and a method for providing therapeutic infusion services. The transportable therapeutic cartridge is configured to be used to manually mix therapeutic agents or to be coupled to a therapeutic agent robotic mixer, such that the robotic mixer can access therapeutic agents disposed in the cartridge and automatically mix therapeutic agents. The cartridge, mixer, and method provide therapeutic infusions in a just-in-time fashion, so as to minimize risk to patients and facility staff while maximizing the use and safety of the therapeutics.

Abstract: A dosage dispenser according to the invention is intended to provide a solution for measuring and dilution of liquid medications and issuing marked and ready for use. The dosage dispenser device carries out actions required for the preparation of a required dose of medication, including identifying ampoules, breaking them, filling a syringe, diluting the medication in a solution, marking the syringe, disposing of waste and documenting the process, all at the patient bedside. The dosage dispenser is aimed at reducing the number of errors in the dosage, which is a problem, menacing medical services throughout the world. The problem is made acute by considerable pressure on the medical teams while carrying out many and complex procedures under pressure in a situation of uncertainty and with variable data.

Abstract: Liquid drug transfer assemblies for use with a drug vial having a drug vial opening stopped by a drug vial stopper. The liquid drug transfer assemblies include a drug vial stopper puncturing member for puncturing a drug vial stopper. The liquid drug transfer assemblies also include a drug vial adapter having a drug vial adapter skirt, an upright drug vial adapter port and a drug vial adapter sleeve downward depending opposite the upright drug vial adapter port and in flow communication therewith. The drug vial adapter is slidingly disposed on the drug vial stopper puncturing member such that on mounting the liquid drug transfer assembly on the drug vial, the drug vial stopper puncturing member punctures the drug vial stopper to form a throughgoing puncture bore and the drug vial adapter sleeve lines the puncture bore.

Abstract: A fully-automated system suitable for use in a hospital setting for filling patient-specific liquid prescriptions to be administered by oral syringes on a just-in-time basis. The system enables hospital pharmacists to simplify and streamline their task, increasing the number of prescriptions that can be filled in a day, improving patient safety and care by minimizing medication errors and the consequences that ensue.

Abstract: A surgical console having bottles containing retinal tamponading gases and an automatic gas filling module disposed therein for filling an automatic gas filling consumable is disclosed. The automatic gas filling module includes a pair of gas shutoff valves and a regulator connected in series with a port for connection to the automatic gas filling consumable.

Abstract: The invention relates to a container assembly that includes a built-in follow plate for loading a viscous fluid into the barrel of a dispensing device. The assembly includes a drum for holding a viscous fluid therein and a lid for fitting over the drum open top to effect closure of the drum. The assembly includes a horizontally oriented follow plate detachable from the lid. The follow plate includes a central hub arranged for receiving the barrel of a dispensing device. The follow plate moves in response to a change in the level of fluid in the drum as it is drawn into the barrel of the dispensing device.

Abstract: A container is provided comprising a receiving vessel (12) and an outlet part (14), wherein the outlet part (14) comprises a one-way valve (24) and at least one bypass passage (32) bypassing the one-way valve (24), wherein the outlet part (14) is at least partly movable with respect to the receiving vessel (12) between a closed position and an opened position, wherein in the closed position the receiving vessel (12) seals the bypass passage (32) and in the opened position the receiving vessels (12) unseals the bypass passage (32). Due to the one-way valve (24) of the alternative container (10) the filling is facilitated without complicating emptying, since it is prevented that the content (42) of the container (10) flows back accidently.

Abstract: A vertical round container (1) for storing liquids comprises a floating cover (6) covering the surface of the liquid. The cover is sealed in relation to the container wall by means of flexible sealing elements (18, 19) and includes, on the lower side thereof, at least one compartment (62) which is open towards the liquid and contains gaseous media/vapors. Devices (40a) are provided for determining the submersion depth of the cover, and supply/discharge lines (29) are provided for modifying the quantity of the gaseous medium in the at least one compartment. The supply/discharge lines for the gaseous medium are connected to a central unit (28) provided outside the container region.

Abstract: Needle guides are disclosed. An example needle guide includes a base; a housing configured to hold a container, the housing disposed on the base such that a longitudinal axis of the container is held at a first angle to vertical; and a syringe holder configured to guide insertion of a needle of a syringe into the container, the syringe holder disposed on the housing such that the syringe is inserted into the container at a second angle to the longitudinal axis of the container.

Abstract: A pressure-stable cylinder/piston unit which blocks water vapor and oxygen and is designed for a needle-free injector, with a chamber arranged in a cylinder, which blocks water vapor and oxygen, and designed for long-term and sterile storage of an injection solution, an end wall with at least one nozzle bore or one outlet element, a pressure-stable outer cylinder, and a pressure-stable piston arranged movably in the chamber and blocking water vapor and oxygen. Methods for bubble-free, automatic or manual filling of the cylinder/piston unit, also at atmospheric pressure are also disclosed.

Abstract: An automated medication preparation system for preparing a prescribed dosage of medication in a drug delivery device includes a plurality of stations for receiving, handling and processing the drug delivery device so that the prescribed dosage of medication is delivered to the drug delivery device and a transporting device that receives and holds more than one drug delivery device and moves the drug delivery devices in a controlled manner from one station to another station. The system is configured so that two or more separate drug delivery devices can be acted upon at the same time.

Abstract: A syringe filling apparatus having a housing, a fluid reservoir, and a port for providing a fluid pathway between the syringe and the fluid reservoir. The apparatus has an alarm to indicate the fluid level within the reservoir. The apparatus has a heating system for heating the fluid within the reservoir to a predetermined temperature.

Abstract: A drug solution transfer method includes step S1 of inserting a needle into a drug solution container through a rubber stopper and sucking drug solution in the drug solution container, step S2 of checking whether or not a solution collection inlet at a tip of the needle has shifted into the rubber stopper upon extracting the needle from the drug solution container, step S3 of pulling a plunger of a syringe provided with the needle so that an inside of the needle and an inner space of the syringe have negative pressure, and step S4 of relatively shifting the needle along with the syringe to be distant from the drug solution container so as to extract the solution collection inlet of the needle from the rubber stopper.

Abstract: A syringe-to-syringe mixing apparatus comprises first and second syringes adapted to be coupled at their respective outlets to fluidly connect the syringes. The first syringe includes a plunger having a hollow plunger barrel and a distal end defining a lumen therethrough. The lumen is initially closed by a septum, which in one embodiment is an elastomeric stopper mounted over the end of the plunger. The mixing apparatus further includes a third syringe slidably disposed within the plunger barrel. The third syringe includes a hollow needle adapted to pierce the septum to allow fluid from the third syringe to be injected into fluid within the coupled first and second syringes.

Abstract: A co-infusion apparatus is provided to prevent foaming of a transfusion when the transfusion is introduced into a medicine container, and to prevent the transfusion from directly hitting a medicine inside a vial. The co-infusion apparatus includes: a container holding section for holding a medicine container and tilting the medicine container; a syringe holding section for holding a syringe, tilting the syringe, and varying an amount of insertion of a plunger of the syringe into a barrel of the syringe: and an insertion operation section for inserting a needle of the syringe through a mouth of the medicine container which is held by the container holding section, and inserting the needle of the syringe through a mixing port of a transfusion bag.

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough.

Abstract: A medicine mixing device includes a pedestal, a main rotating-base, a sub rotating-base, and a control unit. The pedestal is used to place medicine containers thereon. The main rotating-base includes a holding portion and a main rotating shaft, and rotates around the main rotating shaft. The holding portion holds a syringe for sucking a medicine at its center on its vertical plane. The main rotating shaft is orthogonal to the vertical plane. The sub rotating-base is disposed close to a part of the circumference of the main-rotating base and rotates relatively with respect to the main rotating-base. The sub rotating-base includes a fixing unit and a sub rotating shaft parallel to the main rotating shaft. The fixing unit fixes thereto one medicine container selected from the medicine containers on the pedestal. The control unit controls a medicine to be sucked out of the medicine container into the syringe.

Abstract: A station for reloading a sprayer is disclosed that includes a tank coupled to at least one coating material circuit by a coupler, a docking unit that is adapted to receive a sprayer; and at least one accumulator having a volume that is greater than or equal to the volume of the tank. Each accumulator is connected to at least one circuit by the coupler. The station also includes a mechanism for pressurizing the accumulator. The accumulator is connected to the docking unit which is, in turn, connected to the tank.

Abstract: A syringe for holding fluids susceptible to void formation when frozen and thawed before use. The interior surface of the syringe sidewall may be roughened, which serves to prevent or significantly reduce the incidence of void formation in the fluid. The required level of surface roughening for counteracting void formation may be reduced by increasing the sidewall flexibility. Alternatively, the flexibility of the syringe sidewall may operate over certain thickness ranges to prevent or significantly reduce void formation in the fluid without intentionally roughening the interior surface.

Abstract: The present invention relates to a container system for liquids such as spray fragrances. The system includes a parent container (110) and a child container (120). The parent container provides a first cavity (113) for confining a liquid, and couples detachably to the child container for refilling the child container through a supply opening (111) in the parent container, so that the child container can be used for instance as a travel pack in a handbag or hand luggage. Here the child container is a compact dispenser, comprising a bowl-shaped rigid container (221) having a refill opening (222), which is kept closed by a valve unless the dispenser is connected to a supply container, and a dispense opening (224). These openings are located with a spacing from each other, and a pump (225) dispenses liquid from the dispense opening (224).

Abstract: Some embodiments disclosed herein related to a device for transferring precise amounts of fluid from at least one source container to a at least one target container. In some embodiments, the fluid is first transferred from the source container (e.g., a vial) through a connector to an intermediate measuring container (e.g., a syringe). In some embodiments air can pass through an air inlet and enter the vial to compensate for the volume of fluid withdrawn from the vial. An air check valve or a bag or a filter can prevent the fluid from escaping through the air inlet. The precisely measured amount of fluid can then be transferred from the intermediate measuring container to the target container (e.g., an IV bag). In some embodiments the connector can include a source check valve and a target check valve to direct fluid first from the source container to the intermediate measuring container and then from the intermediate measuring container to the target container.

Abstract: The system for filling a cartridge employs a piston setting device that has a plunger for moving the venting valve of the piston to an open position and a conduit for venting the air from the opened valve under the influence of a vacuum source connected to the conduit via an attachment device.

Abstract: Disclosed in this specification is a medicine container with a flexible flap covering the opening of the container. The opening is closed by the flexible flap when the flexible flap is in a resting position and the opening is opened when the flexible flap is in a flexed position. A hand-operated plunger is equipped with an end configured to mate with the opening such that a seal is established between the plunger and the opening. The plunger is shaped to apply a force to the flexible flap, thereby operating the flexible flap.

Abstract: A barrel support device supports a barrel rotationally about an axis of the barrel with the axis being arranged vertically and an opening of the barrel through which a plunger rod is inserted being directed upward. A chuck of a plunger rod support device holds the plunger rod in a first holding state in which the plunger rod is prevented from rotating about and sliding along its axis and inserts it into the barrel. Then, the chuck enters a second holding state in which the plunger rod is prevented from rotating about its axis but is not prevented from sliding along its axis. A load application device places a load acting downward on the plunger rod, and a rotation application device rotates the barrel in a direction in which the plunger rod is screwed into a gasket in the barrel.

Abstract: A package that is configured to store and dispense fluids. The package includes a container and a dosing dispenser for closing an opening to the container. The dosing dispenser includes a body portion having a syringe receiver and a valve assembly that is configured to permit the flow of fluid from the container to the syringe.

Abstract: An adapter to be pressed into the neck of a bottle to receive a syringe for accessing the bottle contents by a syringe. The adapter has a distal end that extends into the bottle and a normally closed valve located at that distal end to prevent the contents from leaking out of the bottle if the bottle is inverted. An upper flange of the adapter seats against the top of the bottle and is recessed into the top of the bottle to prevent easy access to pry the adapter out of the bottle. A cap is also disclosed that is adapted to be pressed into the neck of a bottle. The cap has an upper lid that is hinged to a lower body to allow the upper hinge to move between a closed position sealing the bottle and an open position where the bottle is accessible by a syringe.