Abstract: Latching mechanisms, storage receptacles with latching mechanisms, and methods of manufacturing and using the same are disclosed. In one aspect, the latching mechanism includes a first latching element, a second latching element, and a ball-locking mechanism. The ball-locking mechanism allows the first latching element to be releasably secured to the second latching element. The latching mechanism may be integrated with a frame, which may be adjustable, and which may further be integrated with a storage receptacle, e.g., one that has a storage compartment and an opening. The components of the latching mechanism may be shaped, sized, or otherwise configured to enable, and facilitate, automated and/or semi-automated handling and manipulation. The latching mechanisms, storage receptacles, and associated handling systems described herein may be used in a logistics network operation.