Maintaining The Natural Appearance Of Plants Or Animal Parts Patents (Class 156/57)
  • Patent number: 11105686
    Abstract: Due to potential sampling errors (due to small tissue samples not necessarily directly from the developing tumor) and limited optical resolution (˜1 micron), cancer may be missed or detected too late for optimal treatment, or conservative interpretation of indeterminate findings could lead to unnecessary surgery. The novel technology herein—Spatial-domain Low-coherence Quantitative Phase Microscopy (SL-QPM)—can detect structural alterations within cell nuclei with nanoscale sensitivity (0.9 nm) (or nuclear nano-morphology) for “nano-pathological diagnosis” of cancer. SL-QPM uses original, unmodified cytology and histology specimens prepared with standard clinical protocols and stains. SL-QPM can easily integrate in existing clinical pathology laboratories. Results quantified the spatial distribution of optical path length or refractive index in individual nuclei with nanoscale sensitivity, which could be applied to studying nuclear nano-morphology as cancer progresses.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: August 31, 2021
    Assignee: University of Pittshurgh-Of the Commonwealth System of Higher Education
    Inventors: Yang Liu, Randall E. Brand, Pin Wang, Shikhar Fnu
  • Patent number: 9475339
    Abstract: A process for dry flower craft includes cutting craft media (dry botanicals with stencils) and mounting the same on any surface or product in combination with other botanical elements like bamboo, grass, weeds, seed, stem, tendrils, fiber, sola wood in any desired manner including an artistic manner. The process includes reducing color loss while drying and storage of vegetation and also during crafting of the vegetation, making stencils of cheapest materials such as cardboard and paper, cutting out motifs, shaping petals in any desired shape, and pasting the same with known adhesives. The botanicals are dried prior to floral collage decoupage by drying while using a mixture of desiccant of silica gel+silversand+non iodized salts (1:1:1 ratio). Finally obtaining floral decoupage or only floral collage or a combination of both in design processing as application of the craft, by making the floral resin laminates by reducing the peroxide harder by 1%.
    Type: Grant
    Filed: April 25, 2011
    Date of Patent: October 25, 2016
    Inventor: Sahu Anuradha
  • Patent number: 9255863
    Abstract: An apparatus and method for producing a coated analytic substrate using a compact and portable automated instrument located in the laboratory setting at the point of use which can consistently produce one or a plurality of coated analytic substrates “on demand” for using the analytic substrate immediately after coating, preferably without a step of rinsing the coated analytic substrate before use. The apparatus preferably uses applicator cartridges having a reservoir containing the coating compositions used to form the coatings. Preferably the cartridges are removable and interchangeable to facilitate the production of individual analytic substrates having different coatings or different coating patterns. These coated analytic substrates have superior specimen adhesion characteristics due to the improved quality of the coatings applied by the coating apparatus and due to the quickness with which the coated analytic substrates can be used in the lab after production.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: February 9, 2016
    Inventor: Lee H. Angros
  • Patent number: 9250253
    Abstract: A carrier strip having a plurality of areas for retaining anatomical pathology specimens may have a backing, a cover coupled to the backing along side regions located along opposite longitudinal edges of the carrier strip and along lateral intermediate regions positioned between each of the plurality of areas for retaining anatomical pathology specimens. The carrier strip may be configured to individually retain each of the anatomical pathology specimens in one of the plurality of areas for retaining anatomical pathology specimens between the backing and the cover. Diagnostic studies of anatomical pathology specimens may be facilitated by distributing a digital copy of an image of the specimen may be to a pathologist. A diagnosis may be received from the pathologist based on the digital image of the specimen.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: February 2, 2016
    Assignee: Prairie Ventures, L.L.C.
    Inventor: Rodney S. Markin
  • Patent number: 8252747
    Abstract: A tissue adhesive sealant includes a cross-linkable protein in a solution that when combined with a cross-linking agent solution including an aldehyde and amino acid containing species reactive with the aldehyde cross-links to form a seal. The sealant is well suited for bonding tissue alone or in combination with a patch. The ratio between the aldehyde and the amino acid containing species is between 20:1 and 1:1 on an aldehyde moiety:amino acid or peptide subunit molar basis. Particularly strong seals are formed when the protein and cross-linking agent are present in a molar ratio of between 15:1 and 1:1.
    Type: Grant
    Filed: July 27, 2009
    Date of Patent: August 28, 2012
    Inventors: Johan Lowinger, Bruno Lowinger, Frank DeLustro, David Cox, David A. Browdie
  • Publication number: 20110183085
    Abstract: A sculpture of at least a head portion of a game animal. The sculpture includes at least a re-created game animal head portion sculpted, textured, molded, and/or painted to substantially conform to the shape, dimensions and, optionally, color of at least the head portion of the game animal, wherein the re-created game animal head portion defines a cavity sized and configured to receive at least one appendage of the game animal. A cover is sized and configured to be positioned over at least a portion of the cavity, such that when the appendage is received in the cavity of the re-created animal head portion and the cover is disposed over the cavity, the sculpture substantially resembles at least the head portion of the game animal.
    Type: Application
    Filed: January 4, 2011
    Publication date: July 28, 2011
    Applicant: AMERICAN WILDLIFE STUDIOS, INC.
    Inventor: David E. Spiess
  • Publication number: 20100089516
    Abstract: The present invention intends to mount and preserve a thin section prepared from a freeze-embedded sample using an adhesive plastic film as a support for the thin section, in a state of being attached to the adhesive plastic film, as a permanent specimen that can be observed on an optical microscope, after staining the thin section in a state of being attached to the adhesive plastic film. For this purpose, using an adhesive plastic film having a strong adhesion even at a lower temperature (e.g., ?25° C.), a thin section that is kept in its shape is prepared. Subsequently, the thin section is stained while being attached to the adhesive plastic film. After that, the thin section is permeated with a water-soluble resin that can be polymerized upon irradiation with light or heating. The thin section is closely attached to a glass plate having the same resin coated thereon, and is then irradiated with light or heated, thereby causing polymerization of the water-soluble resin.
    Type: Application
    Filed: February 18, 2008
    Publication date: April 15, 2010
    Inventor: Tadafumi Kawamoto
  • Patent number: 7011723
    Abstract: A method of forming an adhesive force includes removing a seta from a living specimen, attaching the seta to a substrate, and applying the seta to a surface so as to establish an adhesive force between the substrate and the surface. The seta is applied to the surface with a force perpendicular to the surface. The seta is then pulled with a force parallel to the surface so as to preload the adhesive force of the seta.
    Type: Grant
    Filed: January 6, 2003
    Date of Patent: March 14, 2006
    Assignees: The Regents of the University of California, The Board of Trustees of the LeLand Stanford Junior University
    Inventors: Robert J. Full, Ronald S. Fearing, Thomas W. Kenny, Kellar Autumn
  • Patent number: 6709722
    Abstract: A method for producing decorative panels for use in vehicle interiors. A layer 3 of plant components, such as leaves 6, is glued onto a base layer 2, formed of superposed layers of sized paper and blank veneer sheets disposed on a metal or plastic carrier 1, whose shape allows it to be mounted to dashboards and/or the side panels of the interior. A transparent varnish layer 4 is then applied to the layer of plant components.
    Type: Grant
    Filed: May 11, 2001
    Date of Patent: March 23, 2004
    Assignee: Holzindustrie Bruchsal GmbH & Co. KG
    Inventors: Matthias Goldschmid, Thomas Hoffman
  • Publication number: 20040005454
    Abstract: A method of forming an adhesive force includes removing a seta from a living specimen, attaching the seta to a substrate, and applying the seta to a surface so as to establish an adhesive force between the substrate and the surface. The seta is applied to the surface with a force perpendicular to the surface. The seta is then pulled with a force parallel to the surface so as to preload the adhesive force of the seta.
    Type: Application
    Filed: January 6, 2003
    Publication date: January 8, 2004
    Applicants: The Regents of the University of California, a California corporation, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Robert J. Full, Ronald S. Fearing, Thomas W. Kenny, Kellar Autumn
  • Patent number: 6652684
    Abstract: The glue-on tissue mount is a device to hold small and/or irregular-shaped biologic tissue so tissue can be manipulated, cut, trimmed, split or divide for transplant and reconstructive surgery. Biologic tissue is quickly mounted onto an acrylic mount with fast-bonding cyanoacrylate glue. On the mount tissue can be held firmly. The tissue can be cut on the mount like on a cutting board or dissected into layers. The mount can rest on flat surfaces and be used with an operating microscope or held between fingers. The glue-on tissue mount has a spherical acrylic mounting surface 12 or flat acrylic mounting surface 14 upon which the tissue is glued. The size and shape of the tissue determines if a spherical or flat mount is used. The mounting surface is attached to a cylindrical base 10 that is easily held. If the glue adhesion breaks the tissue can be anchored with sutures tied to the eyelets in the hexagonal footing of the base 10.
    Type: Grant
    Filed: November 5, 2001
    Date of Patent: November 25, 2003
    Inventor: Ira G. Wong
  • Patent number: 6589650
    Abstract: A cover slip material and a method of making and using the same are provided. The material comprises (a) a light transmissible polymeric backing having first and second surfaces; (b) a tack free bonding layer disposed on the first surface of the backing, the bonding layer comprising polymers selected from the group consisting of acrylate, methacrylate, and combinations thereof; and (c) a protective coating disposed on the second surface of the backing. Upon exposure to an environmentally friendly activating solvent such as terpene, d-limonene, esters of coconut oil and aliphatic hydrocarbon blends, the bonding layer acquires tacky properties causing the cover slip to adhere to a specimen previously mounted on a microscope slide.
    Type: Grant
    Filed: August 7, 2000
    Date of Patent: July 8, 2003
    Assignee: 3M Innovative Properties Company
    Inventors: Michael Govek, Babu N. Gaddam, Cynthia M. Hogerton, Audrey S. Huang, Maureen A. Kavanagh, Junkang Liu, Michael L. Ruegsegger
  • Publication number: 20030079818
    Abstract: A method for an intaglio botanic ornamental transparency comprising the steps of laminating a botanic assemblage between a transparent, deformable cover layer and a fibrous, opaque backing layer, intaglioing completely all backing layer material facing the botanic assemblage, intaglioing partially a narrow optically diffuse auroral boundary zone of backing layer material circumferential to the periphery of the botanic assemblage, abutting thereto, the backing material residue providing a translucent auroral property to the concomitant transparent cover layer.
    Type: Application
    Filed: October 31, 2001
    Publication date: May 1, 2003
    Inventor: Margaret R. Dallosta
  • Publication number: 20030031697
    Abstract: A crosslinkable macromer system and related methods of preparing the system and using the system in the form of a crosslinked matrix between a tissue site and an implant article such as a tissue implant or on the porous surface of a prosthetic device. The macromer system includes two or more polymer-pendent polymerizable groups and one or more initiator groups (e.g., polymer-pendent initiator groups). The polymerizable groups and the initiator group(s), when polymer-pendent, can be pendent on the same or different polymeric backbones. The macromer system provides advantages over the use of polymerizable macromers and separate, low molecular weight initiators, including advantages with respect to such properties as nontoxicity, efficiency, and solubility. A macromer system of the invention can be used as an interface between the tissue site and implant article in a manner sufficient to permit tissue growth through the crosslinked matrix and between the tissue site and implant.
    Type: Application
    Filed: June 20, 2002
    Publication date: February 13, 2003
    Inventors: Stephen J. Chudzik, David L. Clapper
  • Patent number: 6093446
    Abstract: The present invention provides a method of decorating a surface of an item that has an area adapted to display a design. The method comprises spreading onto the area a quantity of a viscous surface preparatory composition that has an initial first state that allows it to be spread onto the surface and is curable to a final state that forms a stable layer adhered to the surface. A pattern sheet is provided with the pattern formed thereon in a medium that will transfer onto the surface of the preparatory composition when in the initial state. The preparatory layer is contacted with the pattern sheet and the pattern thereon for a sufficient time to allow the medium to transfer onto the preparatory layer. After the transfer pattern has been transferred thereon yet before the preparatory layer has cured into the final state, the pattern sheet is removed from contact with the viscous preparatory layer. The preparatory layer is then cured into the final state thereby fixing the transferred pattern.
    Type: Grant
    Filed: January 14, 1994
    Date of Patent: July 25, 2000
    Assignee: Pumpkin Ltd.
    Inventor: Kea Bardeen
  • Patent number: 6007881
    Abstract: The present invention relates to a taxidermy system and method for recreating the head of an animal species. The taxidermy system comprises a taxidermy form in the shape of the head portion of the animal species, at least one eye socket in the taxidermy form and at least one eye insert to be placed within the at least one eye socket. Each eye insert is formed by a simulated eyeball and a capsule surrounding said eyeball. The capsule is formed from a flexible, shape memory material configured to have details such as representations of muscle, eyebrow, and eyelids.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: December 28, 1999
    Inventor: Scott A. Lennard
  • Patent number: 5985063
    Abstract: A plant material is preserved by immersing a cross sectional surface of a severed stem, stalk, trunk or vine of a plant material into a preservative solution. The preservative solution can include a suitable dye. The plant material remains intertwined with its trellis, lattice or similar support during a preservation process. Alternatively, the plant material remains in a natural configuration during the preservation process. Also alternatively, the plant material also remains in a natural orientation during the preservation process. The cut stem, stalk, trunk or vine can be immersed in a container of preservative solution, at or near the time the stem, stalk, trunk or vine is severed. The cut stem stalk, trunk or vine of the plant can also be tied to a container of preservative solution. A rain shroud can also be placed over the container of preservative solution that contains the severed stem, stalk, trunk or vine of the severed plant, to protect the preservative solution during the preservation process.
    Type: Grant
    Filed: August 21, 1998
    Date of Patent: November 16, 1999
    Inventors: Bruce Morford, Melaine Morford
  • Patent number: 5935355
    Abstract: A method of manufacturing acrylic boards containing real flower materials includes adhering real flower materials to an artificial fiber paper or cloth using a glue solution soluble in an acrylic solution, the fiber cloth or paper and the real flower material capable of retaining their malleability in the congealed acrylic solution; and pouring the acrylic solution into a mold holding the fiber paper or cloth with the flower materials adhered thereto; and bending the acrylic board thus obtained to a desirable shape.
    Type: Grant
    Filed: May 1, 1997
    Date of Patent: August 10, 1999
    Inventor: Wen Yan Lai
  • Patent number: 5888325
    Abstract: There are provided decorative articles, and methods of making decorative articles, by applying adhesive and coloring agent to a plant, such as a dandelion, the plant having a stalk and an achene assembly, the achene assembly including a receptacle and a plurality of pappus structures; and then drying the adhesive and coloring agent. Also provided are kits for use in such methods.
    Type: Grant
    Filed: August 8, 1996
    Date of Patent: March 30, 1999
    Inventors: Yoichiro Ito, Lin Qi
  • Patent number: 5843657
    Abstract: A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: December 1, 1998
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Lance A. Liotta, Michael E. Buck, Rhonda Weiss, Zhongping Zhuang
  • Patent number: 5798150
    Abstract: A plant material is preserved by immersing a cross sectional surface of a severed stem, stalk, trunk or vine of a plant material into a preservative solution. The preservative solution can include a suitable dye. The plant material remains intertwined with its trellis, lattice or similar support during a preservation process. Alternatively, the plant material remains in a natural configuration during the preservation process. Also alternatively, the plant material also remains in a natural orientation during the preservation process. The cut stem, stalk, trunk or vine can be immersed in a container of preservative solution, at or near the time the stem, stalk, trunk or vine is severed. The cut stem stalk, trunk or vine of the plant can also be tied to a container of preservative solution. A rain shroud can also be placed over the container of preservative solution that contains the severed stem, stalk, trunk or vine of the severed plant, to protect the preservative solution during the preservation process.
    Type: Grant
    Filed: November 29, 1995
    Date of Patent: August 25, 1998
    Inventors: Bruce Morford, Melaine Morford
  • Patent number: 5662970
    Abstract: A sealed ornament of a dried and pressed flower completely sealed by a film having a low melting point in a substantially absolutely dried state and in a state free from air and moisture in order that the dried and pressed flower maintains its gracefulness without discoloring and fading for long periods. The sealed ornament is further secured to a base, and a cover film may be secured externally of the film having a low melting point as necessary. Additionally, the outermost layer may be coated with a coating resin as necessary.
    Type: Grant
    Filed: June 11, 1992
    Date of Patent: September 2, 1997
    Assignee: Mieko Sakai
    Inventor: Makoto Noguchi
  • Patent number: 5656343
    Abstract: The process and product obtained thereby of obtaining substantially dried flower blooms and other natural predominantly carbohydrate products such as flower stems, leaves, other vegetable matter and insects, which substantially retain their original shape and color, comprising the steps of covering the substrate with particulate matter and then subjecting the covered substrate to a reduced pressure environment to remove most of the water from the substrate.
    Type: Grant
    Filed: April 11, 1995
    Date of Patent: August 12, 1997
    Inventor: Marion A. Baker
  • Patent number: 5456776
    Abstract: The present invention includes a sealed ornament of a dried and pressed flower completely sealed by a film having a low melting point in a substantially absolutely dried state and in a state free from air and moisture in order that the dried and pressed flower maintains its gracefulness without discoloring and fading for long periods and method of producing the same. The sealed ornament may be further secured to a base in a substantially absolutely dried state and in a state free from air and moisture, a cover film secured externally of the film having a low melting point as necessary, and the outermost layer coated with a coating resin as necessary.
    Type: Grant
    Filed: April 22, 1994
    Date of Patent: October 10, 1995
    Assignee: Mieko Sakai
    Inventor: Makoto Noguchi
  • Patent number: 5433803
    Abstract: Flowers or leaves are dried for 3-7 days under controlled atmospheric conditions, and under pressure, between absorbent sheets. The dried material is placed on a backing sheet and covered by a layer of laminating plastic. By the application of pressure, heat and vacuum, the air between the laminating and backing sheets is removed, the laminating sheet moulds around the dried material and is laminated to the backing sheet.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: July 18, 1995
    Assignee: Paul N. Van Draanen
    Inventors: Edward Kwan, John P. Le Sands
  • Patent number: 5354395
    Abstract: A process for manufacturing a card ornamented with a plant or another material. The card comprises a flexible sheet covered on both surfaces with sheets of plastic material that are thermowelded and a plant or other material is applied to the flexible sheet. The plant or other material is first subject to pressure, then dried at an ambient temperature, then subject to a disinfectant wash. The plant is adhered to the flexible sheet. The plastic sheets are placed over the flexible sheet and are thermowelded at an elevated temperature and pressure for sterilization, completing the card. Thermowelding the plastic sheets to the flexible sheet under pressure and temperature is effective for sterilizing the plant or other material.
    Type: Grant
    Filed: June 22, 1993
    Date of Patent: October 11, 1994
    Inventors: Jose M. Fernandez, Angeles Albanchez
  • Patent number: 5230767
    Abstract: A flower press comprising a top plate and a bottom plate with layers of two materials therebetween and straps with VELCRO tabs to secure the press and apply the pressure for pressing flowers therein. The first layer is preferably cardboard to offer firm support for leaves and petals but not crush stems; the second layer is preferably absorbent paper. Two layers of paper are placed between two layers of cardboard. The top plate is preferably made of a transparent material so that it can be used for later display of the pressed floral arrangement.
    Type: Grant
    Filed: December 9, 1991
    Date of Patent: July 27, 1993
    Inventor: Nancy Taylor
  • Patent number: 5227205
    Abstract: This invention provides improved means for displaying and preserving specimens of various kinds, such as flower blossoms. The medium for encapsulating the specimen is a resin material which, when fully cured, is soft and pliable, having a cone penetration value of about 80 to about 400 (10-.sup.1 mm) (ASTM D217-68 or D1403-69) and an ultimate elongation of at least about 100% (ASTM D638-80 or D412). This invention also provides a system for collecting specimens, preserving and dehydrating them, and transporting them to another site where the specimens are encapsulated in the soft, pliable resin for final preservation and display.
    Type: Grant
    Filed: September 6, 1990
    Date of Patent: July 13, 1993
    Assignee: Geoffrey Samuels
    Inventors: Robert S. Dubrow, Geoffrey Samuels, Robert J. Molinari
  • Patent number: 5120583
    Abstract: A composite flower assembly includes a preserved natural flower head 37, a natural receptacle 46 and a natural pedicel segment 51, the flower head being securely fastened atop an artificial calyx 66 and secured to an artificial pedical 33.
    Type: Grant
    Filed: March 4, 1991
    Date of Patent: June 9, 1992
    Inventor: Pedro F. Garcia
  • Patent number: 5023117
    Abstract: A novelty item and method of manufacture which employs the usage of thin apple slices to decorate a form, such as a hat, a basket or whatever. The apple slices are each cut from the top to the bottom of the apple and remain unpeeled, and with core and seeds, to preserve realism. The sliced apples are arranged in layers during assembly of the item, where, typically, lemon juice, a preservative and an aromatic material, as well as some type of decoration, serve to enhance the finished product.
    Type: Grant
    Filed: January 16, 1990
    Date of Patent: June 11, 1991
    Inventor: Kimetha L. Stephens
  • Patent number: 4980194
    Abstract: A flame retardant plant, having flame retardant material substantially uniformly distributed within the plant. The method of producing such plant involves systemic infusion by contacting a freshly exposed plant surface or cut stem or trunk with an aqueous solution, which contains at least the flame retardant material, for a sufficient period of time. The plant may also contain, along with the flame retardant material, a preservative alone or in combination with a dye, produced by the above method.
    Type: Grant
    Filed: June 7, 1989
    Date of Patent: December 25, 1990
    Assignee: Weyerhaeuser Company
    Inventors: C. Jay Allison, David W. Park
  • Patent number: 4917922
    Abstract: A flame retardant plant, having flame retardant material substantially uniformly distributed within the plant. The method of producing such plant involves systemic infusion by contacting a freshly exposed plant surface or cut stem or trunk with an aqueous solution, which contains at least the flame retardant material, for a sufficient period of time. The plant may also contain, along with the flame retardant material, a preservative alone or in combination with a dye, produced by the above method.
    Type: Grant
    Filed: October 28, 1987
    Date of Patent: April 17, 1990
    Assignee: Weyerhaeuser Company
    Inventors: C. Jay Allison, David W. Park
  • Patent number: 4885037
    Abstract: A novel method for producing an article such as a postcard, bookmark or label including a press-dried plant such as a flower is disclosed. The method comprises the steps of interposing a picked plant between two flexible sheets impregnated with a desiccating agent or between one of the flexible sheets and a cushioning sheet; drying the plant under a pressure in a drying atmosphere; hermetically storing the dried plant in a bag of a gas barrier material, the bag containing a desiccating agent and an oxygen absorbing agent; removing the plant from the bag shortly before producing the article carrying the press-dried plant; placing the plant on a surface of a substrate, and; forming a transparent or translucent overlayer over the plant so that air does not remain between the overlayer and the surface of the substrate.
    Type: Grant
    Filed: June 1, 1988
    Date of Patent: December 5, 1989
    Assignee: Esu-Oh Giken Co., Ltd.
    Inventor: Takemi Ohkubo
  • Patent number: 4853262
    Abstract: A cover film for use in microscopy which has an excellent adhesion with a slide glass and does not cause blocking during storage is obtained by coating a solution of a polymer adhesive having a glass transition temperature of at least 50.degree. C. in an organic solvent on a transparent substrate and evaporating the organic solvent.
    Type: Grant
    Filed: August 11, 1986
    Date of Patent: August 1, 1989
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Ikutaro Horie, Masashi Ishiyama, Teiichi Tomizuka
  • Patent number: 4705705
    Abstract: A process for the production of slides with one or more reaction fields, which are bounded by a hydrophobic surface coating and which, for the fixing of the preparations to be examined, are coated with substances having an affinity therefore is characterized in that(a) the regions of at least one surface of the slide which correspond to the reaction fields to be formed are covered with a material which adheres to the surface and which is removable,(b) the entire surface of the slide treated in this manner is coated with a hydrophobic material,(c) the reaction fields are exposed by removal of the covering material, and(d) the exposed reaction fields are coated with the substance having an affinity for the preparations to be examined,and the slides obtained by means of this process.
    Type: Grant
    Filed: April 18, 1986
    Date of Patent: November 10, 1987
    Assignee: Paul Marienfeld KG
    Inventor: Klaus Bross
  • Patent number: 4695339
    Abstract: A system for preparing tissue blocks for sectioning in a microtome is provided. A vacuum-retracted membrane of plastic film material is used to draw a tissue block or specimen into planar contact with a polished platform that is positioned in a vacuum receptacle assembly. A cover plate forms a seal between the membrane and the vacuum receptacle assembly, whereupon a vacuum source is activated to retract the membrane against the tissue block and polished platform. The user adjusts any peripheral edges of the tissue block that are not properly oriented or in a planar position. The tissue block is frozen to the platform once it is properly oriented. The membrane is subsequently peeled away from the platform and the platform/block complex is placed into a mounting device and O.C.T. compound is applied thereto. The O.C.T. compound is also applied to a corrugated platform carried by the mounting device, and the polished and corrugated platforms are mated, with the O.C.T. compound and tissue block therebetween.
    Type: Grant
    Filed: October 3, 1986
    Date of Patent: September 22, 1987
    Inventor: David C. Rada
  • Patent number: 4597982
    Abstract: A method is described for applying liquid to flexible sheets, as in staining medical specimens afixed to thin flexible slides. In platen staining methods, flexible slides are centrally curved downward by the attraction of liquid between the slide and platen, thereby damaging the specimen. The invention prevents this damage by placing a glass slide on top of the flexible slide and interjecting a liquid such as alcohol in between. The flexible slide, which acts as a barrier between the two liquid layers, is pulled upward from a platen by the attraction to the overlying liquid.
    Type: Grant
    Filed: November 7, 1983
    Date of Patent: July 1, 1986
    Inventor: William D. Delameter
  • Patent number: 4545831
    Abstract: A method is described for transferring a thin tissue section affixed to a substrate by a first pressure-sensitive adhesive layer to a microscope slide which supports a second pressure-sensitive adhesive layer of polymerizable material. The tissue section is contacted to the second adhesive layer to form a laminate. Following polymerization of the second layer to form a positive bond between the tissue section and microscope slide, the substrate and first adhesive layer are completely removed to expose the tissue section, now affixed to the microscope slide by the polymerized second adhesive layer, for subsequent processing.
    Type: Grant
    Filed: September 13, 1982
    Date of Patent: October 8, 1985
    Assignee: The Mount Sinai School of Medicine
    Inventor: Leonard Ornstein
  • Patent number: 4537648
    Abstract: An automatic specimen sealing system which provides totally automated sealing of glass slides. Slides are ejected sequentially at predetermined intervals onto a conveyor at a predetermined orientation. The size of the specimens held on the slides is detected, and liquid adhesive is supplied onto the slides in an amount determined in accordance with the thus-detected specimen sizes. Glass covers are then placed over the specimens, with the size of the glass covers being also selected in accordance with the specimen size. The slides with the covers placed thereon are next fed to a binding device where the covers and slides are bound together. Finally, the slides are assembled in trays.
    Type: Grant
    Filed: February 28, 1984
    Date of Patent: August 27, 1985
    Assignees: Sankyo Company Limited, Fuji Electric Company Ltd.
    Inventors: Kouji Shiino, Nobuo Hashimoto, Shozo Wada, Keijiro Nakamura, Akio Izumi, Toshio Sato, Takashi Matsui
  • Patent number: 4463117
    Abstract: A heat-stable, polymer-forming composition of a polymerizable material, a transition metal compound, a polymer chain terminator, and, optionally, a preventive antioxidant is disclosed as well as particular uses of such composition.
    Type: Grant
    Filed: April 19, 1982
    Date of Patent: July 31, 1984
    Assignee: Technicon Instruments Corporation
    Inventor: Michael J. Malin
  • Patent number: 4376839
    Abstract: A heat-stable, polymer-forming composition of a polymerizable material, a transition metal compound, a polymer chain terminator, and, optionally, a preventive antioxidant is disclosed as well as particular uses of such composition.
    Type: Grant
    Filed: January 21, 1980
    Date of Patent: March 15, 1983
    Assignee: Technicon Instruments Corporation
    Inventor: Miachael J. Malin
  • Patent number: 4364100
    Abstract: A multi-layer metallized substrate comprises a matrix of sintered silicon particles joined by a thin insulating layer of silicon dioxide or silicon nitride. Semiconductor circuit chips are bonded to the surface of the substrate to form an electrically connected, unitary integrated circuit module structure.
    Type: Grant
    Filed: April 24, 1980
    Date of Patent: December 14, 1982
    Assignee: International Business Machines Corporation
    Inventors: Harold D. Edmonds, Gary Markovits
  • Patent number: 4320157
    Abstract: A method for preserving a large section of biological tissue with a curable polymer such as an acrylic resin by impregnating the large section with the polymer and pressing the impregnated large section between flat plates. These plates are further separated near their edges by an elastomeric material, thereby providing a flat cell in which the opposing cut surfaces of the impregnated large section abut the inner surfaces of the cell plates. Thereafter the cell is filled up with uncured polymer. The polymer is then cured, the plates moving toward each other due to the polymer shrinkage during curing. Finally, the plates are removed. The resulting plastinated sheet is a permanently-preserved large section of biological tissue whose tissue water is completely replaced by a cured polymer, the sheet having a uniform thickness and smooth, even surfaces.
    Type: Grant
    Filed: August 8, 1980
    Date of Patent: March 16, 1982
    Inventor: Gunther von Hagens
  • Patent number: 4302480
    Abstract: A thin cover sheet for use in microscopic staining consists essentially of a transparent, water-insoluble plastic carrier and a coating thereon comprising a colorant, and at least one polymer which is soluble both in water and in lower aliphatic alcohols. A method of microscopic staining comprises applying an aqueous solution or a lower aliphatic alcohol solution onto the side of a microscopic plate containing a test sample to be stained or onto the coating of such a thin cover sheet for use in the microscopic staining and contacting the test sample side of the microscopic plate and the coating side of the thin cover sheet.
    Type: Grant
    Filed: June 15, 1979
    Date of Patent: November 24, 1981
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Wolfgang Fischer, Brigitte Wissel
  • Patent number: 4221823
    Abstract: A process for mounting palynological specimen on a support employing a solution comprising water and at least one substance selected from the group consisting of water-soluble salts of carboxyalkyl hydroxyalkyl cellulose and water-soluble salts of carboxyalkyl cellulose.
    Type: Grant
    Filed: April 21, 1978
    Date of Patent: September 9, 1980
    Assignee: Phillips Petroleum Company
    Inventors: Michael B. Pearson, Sharon A. Meyer, Francis J. Shell
  • Patent number: 4190472
    Abstract: A system for processing and finishing stained glass slides includes a staining rack for receiving stained slides and including a device for discharging the stained slides therefrom, a conveyor for receiving the discharged stained slides from the staining rack, and for transporting the stained slides in a direction away from the staining rack; and a slide finishing station cooperating with the conveyor. The slide finishing station includes a device for depositing glue onto the stained slide; the stained slide carries the glue, and a device is provided for applying a cover glass to the glue-carrying slide.
    Type: Grant
    Filed: September 28, 1977
    Date of Patent: February 26, 1980
    Inventor: Alex Slonicki
  • Patent number: 4188246
    Abstract: A process for making a microscope side having a specimen hermetically sealed on a transparent slide plate by a transparent coating of a plastic material in solid form. Preferably, the plastic material is applied to a slide plate with a specimen thereon in liquid form and converted to a solid coating of transparent plastic material.
    Type: Grant
    Filed: September 21, 1978
    Date of Patent: February 12, 1980
    Inventor: Julius Lipshaw
  • Patent number: 4146414
    Abstract: A method of mechanically applying cover-slips onto slides provided with specimens for microscopic examination, wherein the slides are fed to a coating station at which a solvent film is applied without mechanical contact between the coating member and the specimens and then fed to an application station wherein the cover-slips, which have an adhesive layer on the slides thereof arranged to bear against the solvent layer, are applied onto the solvent layer.
    Type: Grant
    Filed: May 9, 1977
    Date of Patent: March 27, 1979
    Assignee: Cytologiska Centrallaboratoriet AB
    Inventor: Nils G. Stormby
  • Patent number: 4120991
    Abstract: Apparatus and method for permanently and protectively mounting "wet" thin sections of biological specimens on microscope slides, wherein each specimen is initially bathed in a low-volatile solvent containing a low concentration of first polymerizable material. Such solvent is allowed to evaporate, whereby the liquid polymerizable material permeates and protects the specimen. Following solvent evaporation, a second polymerizable material is layered over the specimen. Preferably, the first and second polymerizable materials comprise a mixture of low-volatility, low-viscosity, liquid acrylic reactomers and a U.V. light-sensitive catalyst system. A conventional cover slip or other planar transparent member can be positioned over the polymerizable materials, and the same are polymerized by exposure to U.V. radiation. The first and second now-polymerized materials encapsulate the specimen on the microscope slide, become integral and completely hardened and are fully devoid of any solvent.
    Type: Grant
    Filed: December 10, 1976
    Date of Patent: October 17, 1978
    Assignee: Technicon Instruments Corporation
    Inventors: Leonard Ornstein, Hazel Elizabeth Williams, Julius Intraub
  • Patent number: 4033809
    Abstract: A method for transferring a coverslip from one location to another comprises placing a suction pad on to one surface of the coverslip, applying suction to the suction pad so that the coverslip adheres temporarily to the suction pad and transferring the suction pad with the adhering coverslip from a first location to a second location. The invention also provides a specific apparatus for carrying out the method. Also provided is an apparatus for feeding coverslips singly from a stack of coverslips employing an open bottomed hopper for the stack of coverslips which rests on a plate having a depression, to accommodate a single coverslip, in its upper surface. The invention further provides a substantially automatic apparatus for placing mounting medium and coverslips on to microscope slides which apparatus can include the apparatus for transferring coverslips and the apparatus for feeding coverslips singly from a stack of coverslips.
    Type: Grant
    Filed: May 12, 1976
    Date of Patent: July 5, 1977
    Assignee: John Wyeth & Brother Limited
    Inventor: Peter William Tipton