Enzyme Included In Apparatus Patents (Class 204/403.1)
  • Patent number: 10859525
    Abstract: Provided are sensors for determining the concentration of an analyte in a sample fluid. In certain embodiments, the sensors include conductive particles and exhibit improved uniformity of distribution of one or more sensing chemistry components, increased effective working electrode surface area, and/or reduced entry of interfering components into a sample chamber of the sensor. Methods of using and manufacturing the sensors are also provided.
    Type: Grant
    Filed: April 27, 2018
    Date of Patent: December 8, 2020
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Benjamin J. Feldman, Zenghe Liu, Tianmei Ouyang, Suyue Qian
  • Patent number: 10779756
    Abstract: A lactate sensor arrangement includes a catheter for withdrawing a test fluid sample, a sensor module for measuring an analyte such as lactate in the sample, and a pumping mechanism. A single uninterrupted flow path extends between the pumping mechanism and the catheter and within the flow path resides a sensor module containing a test chamber. The sensor arrangement also includes a control unit or controller that interfaces with a pumping mechanism driver. The sensor arrangement also includes a source of sensor calibration and anticoagulant solution, such as a reservoir, which has a silicone rubber fill septum, a non-woven Teflon air vent, and a check valve sub-assembly.
    Type: Grant
    Filed: March 6, 2017
    Date of Patent: September 22, 2020
    Assignee: Pepex Biomedical Inc.
    Inventor: James L. Say
  • Patent number: 10690616
    Abstract: The present invention relates a setting method for a conducting element of an electrochemical test strip and electrochemical test strip thereof. An inspection body is formed by injection molding polymer plastic materials to coat with the plurality of conducting elements, and an external contact surface on an information outputting end of the conducting element is exposed from an inspection slot of the inspection body, so that the information outputting end of the conducting element is extended from the inspection body. Eventually, the information outputting end is bent to fix on a surface of the inspection body. The present invention is not complex and has more precision and convenience, and the manufacturing cost can be reduced efficiently, so that wide application can be expected in the near future.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: June 23, 2020
    Inventors: Cheng-Feng Chiang, Chien-Ying Chiang, Chien-Yi Chiang
  • Patent number: 10667730
    Abstract: Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: June 2, 2020
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, James H. Brauker
  • Patent number: 10667729
    Abstract: Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: June 2, 2020
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, James H. Brauker
  • Patent number: 10625235
    Abstract: A method for generating a hybrid reaction flows feedstock gas that is also a plasma medium through microchannels. Plasma is generated with the plasma medium via excitation with a time-varying voltage. UV or VUV emissions are generated at a wavelength selected to break a chemical bond in the feedstock gas. The UV or VUV emissions are directed into the microchannels to interact with the plasma medium and generate a reaction product from the plasma medium. A hybrid reactor device includes a microchannel plasma array having inlets and outlets for respectively flowing gas feedstock into and reaction product out of the microchannel plasma array. A UV or VUV emission lamp has its emissions directed into microchannels of the microchannel plasma array. Electrodes ignite plasma in the microchannels and stimulating the UV or VUV emission lamp to generate UV or VUV emissions. One common or plural phased time-varying voltage sources drive the plasma array and the UV or VUV emission lamp.
    Type: Grant
    Filed: October 10, 2017
    Date of Patent: April 21, 2020
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: James Gary Eden, Sung-Jin Park, Charles Shin, Andrey Mironov
  • Patent number: 10618056
    Abstract: Described herein are methods for purification of biological material using high gradient magnetic separation. For example, a method includes: providing a ferromagnetic matrix surrounded by a separation column, the separation column including an elongate body defining a lumen having an inlet and an outlet; applying an external magnetic field to the separation column; saturating unspecific binding sites in the ferromagnetic matrix by applying a buffer solution to the ferromagnetic matrix; and introducing biological material into the lumen of the separation column. In some embodiments, the ferromagnetic matrix is uncoated, and the buffer solution includes at least one macromolecule. In some embodiments, the method further includes incubating the ferromagnetic matrix with the buffer solution for at least three minutes to equilibrate the ferromagnetic matrix.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: April 14, 2020
    Assignee: X-Zell Inc.
    Inventors: Sebastian Chakrit Bhakdi, Prida Malasit
  • Patent number: 10561351
    Abstract: A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: February 18, 2020
    Assignee: GLYSENS INCORPORATED
    Inventors: Joseph Y. Lucisano, Mark B. Catlin, William J. Choi, Payton C. Chu, Joe T. Lin, Timothy L. Routh, Thomas G. Wallner
  • Patent number: 10470691
    Abstract: Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes an electrochemical sensor incorporating a silver/silver chloride reference electrode, wherein a capacity of the reference electrode is controlled.
    Type: Grant
    Filed: December 6, 2016
    Date of Patent: November 12, 2019
    Assignee: DexCom, Inc.
    Inventors: Daiting Rong, Sebastian Böhm, Matthew D. Wightlin
  • Patent number: 10473613
    Abstract: Light-addressable potentiometric sensing units are provided. A light-addressable potentiometric sensing unit comprises a conductive substrate, a metal oxide semiconductor layer, and a sensing layer. The metal oxide semiconductor layer is made of indium gallium zinc oxide, indium gallium oxide, indium zinc oxide, indium oxide co-doped with tin and zinc, tin oxide, or zinc oxide. The wide-band gap characteristic of the metal oxide semiconductor layer enables the light-addressable potentiometric sensing unit to resist the interference from visible light. The light-addressable potentiometric sensing unit therefore exhibits a more stable performance.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: November 12, 2019
    Assignee: CHANG GUNG UNIVERSITY
    Inventors: Chao-Sung Lai, Chia-Ming Yang, Chun-Hui Chen, Tsung-Cheng Chen
  • Patent number: 10451577
    Abstract: Provided is a measuring method using a biosensor, the method including: introducing a sample containing a substance to be measured into an electrochemical measurement cell, wherein the electrochemical measurement cell comprises: an insulating base plate; and an electrode system applying a first voltage to the electrode system; applying a second voltage to the electrode system; obtaining a first signal; obtaining a second signal; and correcting the second signal by the first signal, to determine the concentration of the substance to be measured in the sample.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: October 22, 2019
    Assignee: ARKRAY, Inc.
    Inventor: Koji Katsuki
  • Patent number: 10436736
    Abstract: A measurement device for measuring a property of a fluid, in particular a concentration of a substance or an ion concentration in said fluid or a pH-value of said fluid, comprising: a housing comprising a housing section to be immersed into the fluid during measurement operation, and an aperture foreseen in an outside wall of the housing section, in particular in a side wall surrounding an interior of the housing section or in a front wall closing off a front end of the housing section, for exposing a single sensor for measuring the property of the fluid to the fluid, when the housing section is immersed into the fluid.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: October 8, 2019
    Assignee: Endress+Hauser Conducta GmbH + Co. KG
    Inventor: Frederick J. Kohlmann
  • Patent number: 10416148
    Abstract: A system for measuring a property of a sample in a liquid which includes a test strip and a meter is provided. Some embodiments relate to a diagnostic test strip for collecting a sample, the strip having a plurality of electrodes for measuring a property of the sample, and the strip having a control circuit at a distal region of the strip, the control circuit configured to communicate with a controller of a meter, the control circuit including an embedded temperature sensor, a memory for lot coding and authentication of the test strip, and an inhibit logic for inhibiting the test from being used more than once; and a diagnostic meter for receiving the test strip, the meter having a controller programmed to communicate with the control circuit.
    Type: Grant
    Filed: January 6, 2017
    Date of Patent: September 17, 2019
    Assignee: Trividia Health, Inc.
    Inventors: Brent E. Modzelewski, Steven V. Leone, Bradley Combs
  • Patent number: 10408786
    Abstract: A distributable sampling and sensing instrument for chemical analysis of consumable foods and other agricultural products. The distributable sampling system is used to separate and concentrate the chemicals of interest obtained from samples at remote locations via thermal desorption onto a detachable target substrate that can be analyzed on-site or off-site. The volatile components adsorbed onto the target substrate can be analyzed with specific sensors (e.g., electrochemical sensors) or the assembly can be sent to a central lab and analyzed with conventional chemical instrumentation (e.g., GC-MS). This instrument provides the capability to enable chemical analysis of a wide range of chemical species of interest in a wide range of environments and conditions.
    Type: Grant
    Filed: June 7, 2017
    Date of Patent: September 10, 2019
    Assignee: Chemisensor, LLP
    Inventors: Werner G. Kuhr, Craig Rhodine
  • Patent number: 10390743
    Abstract: Electrode systems are disclosed for measuring the concentration of an analyte under in-vivo conditions, where such systems include a counter electrode having an electrical conductor, a working electrode having an electrical conductor on which an enzyme layer containing immobilized enzyme molecules for catalytic conversion of the analyte is arranged, and a diffusion barrier that slows the diffusion of the analyte from body fluid surrounding the electrode system to enzyme molecules. The enzyme layer is in the form of multiple fields that are arranged on the conductor of the working electrode at a distance from each other.
    Type: Grant
    Filed: June 17, 2016
    Date of Patent: August 27, 2019
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Ewald Rieger, Reinhold Mischler, Ortrud Quarder, Arnulf Staib, Ulrike Kamecke, Ralph Gillen
  • Patent number: 10376188
    Abstract: Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: August 13, 2019
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, James H. Brauker
  • Patent number: 10345258
    Abstract: A printed flexible PH sensor is provided. The printed flexible PH sensor includes a flexible substrate. A working electrode is disposed on the flexible substrate, and the working electrode includes a first silver layer formed on the flexible substrate by an ink-jet printing process, a second silver layer formed on the first silver layer by a silver mirror reaction, and a metal oxide layer disposed on the second silver layer of an end portion of the working electrode. A reference electrode is disposed on the flexible substrate, and the reference electrode includes the first silver layer and the second silver layer formed on the first silver layer, and a silver chloride layer totally covering the second silver layer. A method for fabricating the printed flexible PH sensor is also provided.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: July 9, 2019
    Assignee: Winbond Electronics Corp.
    Inventors: Jia-Chyi Pan, Zi-Li Kuo, Yu-Ting Cheng, Yu-Min Fu
  • Patent number: 10321864
    Abstract: The present invention relates to the field of film materials for biosensors, in particular to a film for biosensors and a preparation method. Provided is an organosilicon polymer, the raw materials thereof comprising the following components: at least one active organosilane, at least one curing agent, at least one optional hydrophilic copolymer and at least one optional regulator and/or filling. The membrane prepared from the provided organosilicon polymer has outstanding oxygen permeability and is adjustable in water absorption rate, and can put regulation and restriction on the diffusion of analytes (e.g. glucose) and interferents (e.g. acetaminophen). Meanwhile, the provided organosilicon polymer film also has indispensable physical strength and superior biocompatibility, and can serve as a multifunctional polymer film material for biosensors, such as anti-interference layer, analyte regulating layer and biocompatible layer.
    Type: Grant
    Filed: April 4, 2014
    Date of Patent: June 18, 2019
    Assignee: MEDTRUM TECHNOLOGIES INC.
    Inventor: Xiaoqing Zhu
  • Patent number: 10274455
    Abstract: An electrical circuit element, defined as “pixel”, can include at least one silicon nanowire open for contact with a medium for sensing; a metal electrode open for contact with said medium and used for feeding a high-frequency sinusoidal stimulation in impedance measurements and for sensing properties of said medium; implanted source and drain electrodes connected to said silicon nanowire and leaving the gate area and parts of said electrode open for contact with said medium; electrical metal contacts for connecting said pixel to an electrical circuit; and a reference electrode open for contact with said medium for creating a three-electrode-cell system and providing a constant gate potential in the circuit. Some embodiments provide a microelectronic sensor and wearable-patch sensor based on the array of these pixels. Also, some embodiments provide methods for performing DC readout, AC readout and a triple readout combining both DC and AC readouts and temperature sensing.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: April 30, 2019
    Assignee: RG SMART PTE. LTD.
    Inventors: Ayal Ram, Amir Lichtenstein, Xuan-Thang Vu, Jessica Ka-Yan Law, Miriam Schwartz, Jannick Wilhelm, Thanh Chien Nguyen
  • Patent number: 10233424
    Abstract: Compositions and methods are disclosed herein for producing one or more immunoglobulins in an isolated cytotoxic B lymphocyte cell line. An isolated cell line includes an isolated B lymphocyte cell line capable of expressing at least one exogenously incorporated membrane immunoglobulin reactive to a first antigen and at least one endogenous secreted immunoglobulin reactive to a second antigen, and further capable of expressing at least one exogenously incorporated recombinant B cell receptor that signals for expression of cytotoxic effector molecules.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: March 19, 2019
    Assignee: Elwha LLC
    Inventors: Roderick A. Hyde, Wayne R. Kindsvogel, Gary L. McKnight
  • Patent number: 10094799
    Abstract: Provided is an electron mediator system, which may include a first transition metal complex and a second transition metal complex, wherein a working potential of the electron mediator system may be substantially the same as a molar average of a working potential of the first transition metal complex and a working potential of the second transition metal complex.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: October 9, 2018
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Seong-je Cho, Kwang-bok Kim, Jae-hong Kim, Su-ho Lee, Sun-tae Jung, Jae-geol Cho, Chul-ho Cho
  • Patent number: 10067083
    Abstract: This invention relates to an apparatus suitable to be used for analyzing at least one sample with an electrochemical sensor array, comprising at least one upper layer; at least one inlet and at least one outlet opening provided on the upper layer; at least one lower layer having at least one recess thereon; at least one two-sided adhesive membrane matching to the recess; at least one sensor array secured to the lower layer, at least one reference electrode, at least one counter electrode, at least one communication channel, at least one conductive line providing a connection between the working electrode and the communication channel on at least one plate; at least one further two-sided adhesive membrane spaced from the adhesive membrane positioned on the lower layer and enabling the sensor array to be secured to the upper layer.
    Type: Grant
    Filed: April 6, 2015
    Date of Patent: September 4, 2018
    Assignee: TUBITAK
    Inventors: Yildiz Uludağ, Mahmut Şamil Sağiroğlu, Aylin Ersoy, Edis Ardinç, Sinan Budak, Atike Demiralp, Halit Hakan Efe
  • Patent number: 10011549
    Abstract: Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample.
    Type: Grant
    Filed: July 6, 2015
    Date of Patent: July 3, 2018
    Assignee: ROBERT BOSCH GMBH
    Inventors: Christopher Johnson, Sam Kavusi, Nadezda Fomina, Habib Ahmad, Autumn Maruniak, Christoph Lang, Ashwin Raghunathan
  • Patent number: 9976168
    Abstract: A method is provided for measuring a substance using a biosensor, the method comprising: introducing a sample containing the substance into an electrochemical measurement cell which comprises an insulating base plate; at least two electrodes formed on the insulating base plate; and a reagent layer that is disposed on at least one of the electrodes and comprises an oxidoreductase; applying a voltage to the electrodes; detecting a charge transfer limiting current which is generated due to the transfer of electrons from the substance in the sample to the electrode; and determining the concentration of the substance contained in the sample based on the charge transfer limiting current.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: May 22, 2018
    Assignees: ARKRAY, Inc., BioEngineering Laboratories, LLC
    Inventor: Koji Katsuki
  • Patent number: 9945841
    Abstract: A method for measuring cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate, wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, and measuring a redox potential of the cell. A method for screening a substance affecting cell cycles includes immobilizing a capture specifically binding to a cell membrane protein to a substrate; wherein the cell membrane protein is a counterpartner binding to the capture, binding a cell having the cell membrane protein as the counterpartner to the capture, treating a test substance of interest for analysis to a cell, and measuring a redox potential of the cell.
    Type: Grant
    Filed: January 25, 2012
    Date of Patent: April 17, 2018
    Assignee: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION SOGANG UNIVERSITY
    Inventors: Jeong-Woo Choi, Tae-Hyung Kim, Kafi Md Abdul
  • Patent number: 9933386
    Abstract: The present invention relates a setting method for a conductive object of electrochemical test strip. In the embodiment, this manufacturing process is not complex, convenient, and has well precision, such that the cost of manufacturing an electrochemical test strip is reduced effectively, the disadvantage of past manufacturing process is improved. The present invention is highly applied and convenient, so that wide application can be expected in the future.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: April 3, 2018
    Assignee: KUANG HONG PRECISION CO., LTD.
    Inventors: Cheng-Feng Chiang, Jung-Chuan Chiang, Wen-Te Chiang, Chien-Ying Chiang, Chien-Yi Chiang
  • Patent number: 9927392
    Abstract: Embodiments of sensing devices include one or more integrated circuit (IC) die, a housing, and a fluid barrier material. Each IC die includes an electrode-bearing surface and a contact surface. One of the die includes an SFET with a sensing electrode proximate to the electrode-bearing surface. The same or a different die includes a reference electrode proximate to the electrode-bearing surface. The die(s) also include IC contacts at the contact surface(s), and conductive structures coupled between the SFET, the reference electrode, and the IC contacts. The housing includes a mounting surface, and housing contacts formed at the mounting surface. The IC contacts are coupled to the housing contacts. The fluid barrier material is positioned between the mounting surface and the IC die. The fluid barrier material provides a fluid barrier between the IC and housing contacts and a space that encompasses the sensing electrode and the reference electrode.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: March 27, 2018
    Assignee: NXP USA, INC.
    Inventors: Raymond M. Roop, Jose Fernandez Villasenor, Stephen R. Hooper, Patrice M. Parris
  • Patent number: 9903877
    Abstract: The present invention relates to analytical testing devices including micro-environment sensors and methods for assaying coagulation in a fluid sample applied to the micro-environment sensors, and in particular, performing one or more types of coagulation assays using one or more micro-environment sensors in a single point of care combined test cartridge. For example, the present invention may be directed to test sensor including at least one transducer coated with a polymer layer. The polymer layer comprises a thrombin-cleavable peptide with a detectable moiety.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: February 27, 2018
    Assignee: Abbott Point of Care Inc.
    Inventors: Tian-Xian Zhao, Anjulia Chiu-Yuk Wong, Glenn Brian Martin, Katrina Petronilla Di Tullio, Isabelle Louisette Thibodeau, Steven Roy Breeze, Smitha R K Sutrala, Eric Hong, Sheila Diane Ball
  • Patent number: 9903856
    Abstract: The present disclosure provides an optical biosensor based on a complex including a porous support on a chip and enzyme(s) immobilized inside the pores of the porous support, and a method for preparing the same. Since the colored product does not flow out of the pores but is concentrated therein, the optical biosensor of the present disclosure has remarkably improved sensitivity. In addition, it is possible to carry out quantitative determination and qualitative analysis since color intensity increases with time.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: February 27, 2018
    Assignees: KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Jungbae Kim, Min-Gon Kim, Hyou-Arm Joung, Yongho Wee
  • Patent number: 9880128
    Abstract: The present disclosure relates to an electrode strip, a sensor strip, a system thereof and a manufacturing method thereof. The sensor strip includes a first reactive film, a second reactive film and a vent hole. The first reactive film includes a substrate, a first electrode layer and a first insulation layer. The first end of the first insulation layer is concaved to a first depth to form a first reactive area. The second reactive film includes a second electrode layer and a second insulation layer. The first end of the second insulation layer is concaved to a second depth to form a second reactive area. The vent hole penetrates the second insulation layer, the second electrode layer and the first insulation layer so as to connect the first reactive area and the second reactive area.
    Type: Grant
    Filed: March 6, 2015
    Date of Patent: January 30, 2018
    Assignee: Apex Biotechnology Corp.
    Inventors: Ying-Che Huang, Lan-Hsiang Huang, Ching-Yuan Chu
  • Patent number: 9879298
    Abstract: The present invention relates to a composition for forming an electrode, an electrochemical sensor comprising the same, and a method for determining an analyte using the electrochemical sensor.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: January 30, 2018
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Gregor Ocvirk, Claudia Gaessler-Dietsche
  • Patent number: 9823212
    Abstract: The present invention relates a setting method for a conductive object of electrochemical test strip. In the embodiment, this manufacturing process is not complex, convenient, and has well precision, such that the cost of manufacturing an electrochemical test strip is reduced effectively, and the disadvantage of past manufacturing process is improved. The present invention is highly applied and convenient, so that wide application can be expected in the future.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: November 21, 2017
    Assignee: KUANG HONG PRECISION CO., LTD.
    Inventors: Cheng-Feng Chiang, Jung-Chuan Chiang, Wen-Te Chiang, Chien-Ying Chiang, Chien-Yi Chiang
  • Patent number: 9823213
    Abstract: An electrochemical test strip, measurement system and method for determining sample content in the reactive region of the electrochemical test strip are presented. The electrochemical test strip comprises an insulator substrate which includes an electrode system disposed thereon. The electrode system includes at least one pair of electrodes. A lower plate which includes a reactive region and a sampling cell is disposed on the insulator substrate. An upper plate is disposed on the lower plate, wherein the at least one pair of electrodes is designed as an electrical loop adjacent to the sampling port.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: November 21, 2017
    Assignee: Apex Biotechnology Corp.
    Inventors: Ching Yuan Chu, Chun Ming Cheng, Po Min Wang, Lee Teng Yi Wu
  • Patent number: 9817009
    Abstract: It is an object of certain embodiments of the present invention to suppress variance in measurement results from a biological information measurement device and enhance measurement accuracy. A biological information measurement device comprises a main case having a sensor mounting component for mounting a sensor that senses biological information, a measurement component that connects to the sensor mounting component, a controller that connects to the measurement component, a first timer that connects to the controller, and a second timer that connects to the controller. The controller has a measurement mode in which a measurement operation is performed through the measurement component. In the measurement mode, the controller executes the measurement operation based on a preset measurement timing using the first timer, and determines the suitability of the measurement operation based on the preset measurement timing, using the second timer.
    Type: Grant
    Filed: September 27, 2013
    Date of Patent: November 14, 2017
    Assignee: Panasonic Healthcare Holdings Co., Ltd.
    Inventors: Yuichi Sugiue, Hiroshi Andoh
  • Patent number: 9788766
    Abstract: Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: October 17, 2017
    Assignee: DexCom, Inc.
    Inventors: Peter C. Simpson, James H. Brauker
  • Patent number: 9750445
    Abstract: An analyte sensor for the continuous or semi-continuous monitoring of physiological parameters and a method for making the analyte sensor are disclosed. The analyte sensor includes a crosslinked copolymer network in contact with a surface of an electrode. The copolymer network has voids formed by the removal of a porogen, and an analyte sensing component is immobilized within the network. The method involves forming a solution of the precursors of the copolymer, depositing the mixture on a surface of an electrode, and curing the deposited mixture to provide the analyte sensor.
    Type: Grant
    Filed: June 28, 2013
    Date of Patent: September 5, 2017
    Assignee: Verily Life Sciences LLC
    Inventors: Zenghe Liu, Jeffrey George Linhardt, Huanfen Yao
  • Patent number: 9702843
    Abstract: The present invention relates to a protein-immobilized membrane (14) including a cell membrane homologous layer (14A) and a protein (14B) immobilized to the cell membrane homologous layer (14A), where the protein contains cytochrome or a cytochrome complex. The present invention also relates to a method for forming a protein-immobilized membrane (14), and an enzyme-immobilized electrode and a biosensor (X1) provided with a protein-immobilized membrane (14). Preferably, the cell membrane homologous layer (14A) may contain a phospholipid polymer, and the protein (14B) may be CyGDH including an ? subunit having a glucose dehydrogenase activity and cytochrome C having a function of electron transfer.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: July 11, 2017
    Assignee: ARKRAY, Inc.
    Inventors: Koji Katsuki, Hideaki Yamaoka
  • Patent number: 9658190
    Abstract: A nanopore based sequencing chip package is disclosed. The nanopore based sequencing chip package includes a reservoir defined by a plurality of surfaces. The chip package includes a nanopore cell array comprising a plurality of nanopore sensor cells enclosed by the reservoir. Each nanopore sensor cell has a working electrode. At least one surface of the reservoir is configured to be in contact with a conducting fluid when the conducting fluid is flowing through the reservoir. The chip package further includes a counter electrode disposed on the at least one surface of the reservoir.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: May 23, 2017
    Assignee: Genia Technologies, Inc.
    Inventors: Bill Maney, David Bruce Robinson, Markus Wallgren, Robert A. Yuan
  • Patent number: 9658183
    Abstract: Analytes in a liquid sample are determined by methods utilizing sample volumes from about 0.3 ?l to less than 1 ?l and test times from about 3.5 to about 6 seconds after detection of the sample. The methods are preferably performed using small test strips including a sample receiving chamber filled with the sample by capillary action.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: May 23, 2017
    Assignees: Roche Diabetes Care, Inc., Roche Operations Ltd.
    Inventor: Christopher D. Wilsey
  • Patent number: 9638658
    Abstract: The concentration of glucose in a blood sample is determined by methods utilizing test strips having a sample receiving cavity having a volume from about 0.3 ?l to less than 1 ?l and determining the glucose concentration within a time period from about 3.5 seconds to about 8 seconds.
    Type: Grant
    Filed: April 24, 2015
    Date of Patent: May 2, 2017
    Assignees: Roche Diabetes Care, Inc., Roche Operations Ltd.
    Inventor: Christopher D. Wilsey
  • Patent number: 9632080
    Abstract: A diagnostic multi-layer dry phase test strip with integrated biosensors for use in measuring more than one analyte in a fluid sample includes a body having a port for introducing a fluid sample. Within the body is a spreader layer configured to evenly spread the fluid sample received through the port. The test strip further includes at least one enzyme reaction layer in fluidic communication with the spreader layer. The test strip also includes a first electrode layer in fluidic communication with the at least one enzyme reaction layer. The first electrode layer includes a set of electrodes for each of the at least one enzyme reaction layer. Each set of electrodes is capable of electrically interacting with the fluid sample.
    Type: Grant
    Filed: June 11, 2009
    Date of Patent: April 25, 2017
    Assignee: Polymer Technology Systems, Inc.
    Inventor: Björn F. Lindemann
  • Patent number: 9585605
    Abstract: A lactate sensor arrangement includes a catheter for withdrawing a test fluid sample, a sensor module for measuring an analyte such as lactate in the sample, and a pumping mechanism. A single uninterrupted flow path extends between the pumping mechanism and the catheter and within the flow path resides a sensor module containing a test chamber. The sensor arrangement also includes a control unit or controller that interfaces with a pumping mechanism driver. The sensor arrangement also includes a source of sensor calibration and anticoagulant solution, such as a reservoir.
    Type: Grant
    Filed: May 18, 2012
    Date of Patent: March 7, 2017
    Assignee: Pepex Biomedical, Inc.
    Inventor: James L. Say
  • Patent number: 9465005
    Abstract: Analyte sensors for determining the concentration of an analyte in a sample. The sensors have a sample chamber having an inlet with a projection extending from an edge of the sensor for facilitating flow of sample into the sample chamber.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: October 11, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventor: Yi Wang
  • Patent number: 9459230
    Abstract: Reagent matrices and methods are disclosed for improving the stability of test elements with respect to degradation by humidity in the air. The reagent matrices and methods are based upon using an effective amount of a deliquescent material to decrease the sorption of water from the air by other components of a reagent matrix. When the test element is a glucose-specific test strip, and the reagent matrix can include a glucose dehydrogenase enzyme and/or a flavin adenine dinucleotide cofactor, a nitrosoaniline mediator, and a film former, where the deliquescent material may include a salt such as sodium chloride in an amount effective to absorb water from the atmosphere at a rate that is faster than the rate at which the other components of the reagent matrix absorb water from the atmosphere.
    Type: Grant
    Filed: March 5, 2015
    Date of Patent: October 4, 2016
    Assignee: Roche Diabetes Care, Inc.
    Inventors: Stacy H. DuVall, Sibylle Kachel, Georgeta C. Lica, Wilhelm Schabel, Philip Scharfer
  • Patent number: 9459229
    Abstract: The present invention relates to electrochemical sensor strips and methods of determining the concentration of an analyte in a sample or improving the performance of a concentration determination. The electrochemical sensor strips may include at most 8 ?g/mm2 of a mediator. The strips, the strip reagent layer, or the methods may provide for the determination of a concentration value having at least one of a stability bias of less than ±10% after storage at 50° C. for 4 weeks when compared to a comparison strip stored at ?20° C. for 4 weeks, a hematocrit bias of less than ±10% for whole blood samples including from 20 to 60% hematocrit, and an intercept to slope ratio of at most 20 mg/dL. A method of increasing the performance of a quantitative analyte determination also is provided.
    Type: Grant
    Filed: December 10, 2015
    Date of Patent: October 4, 2016
    Assignee: Ascenia Diabetes Care Holdings AG
    Inventors: Huan-Ping Wu, Christine D. Nelson, Hope Spradlin, Eric Maurer
  • Patent number: 9383332
    Abstract: A test strip for use with an analyte meter comprises an integrated power source, such as a battery wherein the test strip is configured upon insertion into the meter to provide sufficient power for completing a sample assay without requiring a separate power source in the meter.
    Type: Grant
    Filed: September 24, 2013
    Date of Patent: July 5, 2016
    Assignee: LifeScan Scotland Limited
    Inventors: David Elder, Stanley Young, Brian Guthrie, John Young
  • Patent number: 9365882
    Abstract: An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an electron acceptor compound simultaneously to an electrode. For example, here are used diaphorase as the enzyme and 2-amino-3-carboxy-1,4-naphthoquinone (ACNQ) as the electron acceptor compound.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: June 14, 2016
    Assignee: Sony Corporation
    Inventors: Atsushi Sato, Tokuji Ikeda, Kenji Kano
  • Patent number: 9354194
    Abstract: An analyte meter with a test strip port that detects an orientation of a test strip inserted therein. A control circuit of the test meter is configured to apply a first predetermined analyte measurement signal to a test strip electrode in response to detecting a first orientation of the test strip, and a second predetermined analyte measurement signal to the same, or a different, electrode in response to detecting a second orientation of the test strip.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: May 31, 2016
    Assignee: Cilag GmbH International
    Inventors: James Iain Rodgers, Lawrence Ritchie, Anna Zvikhachevskaya, Jonathan Nelson, Carlos Morales
  • Patent number: 9320467
    Abstract: Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: April 26, 2016
    Assignee: Abbott Diabetes Care Inc.
    Inventors: Fei Mao, Adam Heller
  • Patent number: 9290862
    Abstract: An apparatus and system for contacting a mobile elongate solid phase, e.g. a ribbon with a flowing fluid phase, and a method for using the same in, for example solid phase synthesis. A particular apparatus comprises (i) a conduit which is of circular or non-circular transverse cross section and which defines a lumen to contain both the flowing fluid phase and the mobile elongate solid phase; (ii) fluid phase ports in communication with the lumen to allow the fluid phase to enter the lumen, flow through it and exit it; and (iii) solid phase ports in communication with the lumen to allow the mobile solid phase to enter the lumen, move through it and exit it, the apparatus being adapted to prevent fluid egress from its interior through the solid phase ports.
    Type: Grant
    Filed: January 6, 2010
    Date of Patent: March 22, 2016
    Assignee: Swedish Biomimetics 3000 Limited
    Inventor: Andrew Richard Russell Prewer