Abstract: The present invention is directed to an ampule solution dispenser applicator. It includes a container base, a plunger, an absorbent applicator and a cover. The container base has a collar or neck adapted to receive an ampule of a solution to be dispensed and the container is adapted to hold at least half of the ampule firmly. It also has an open area which would remain open surrounding an ampule upon insertion of an ampule into the container base and it has means for removably attaching a cover thereto. The plunger is adapted to be fitted over the collar of the base and adapted to have a first position resting on the collar and adapted to be forcibly permanently attached to the collar at a second position. The plunger includes means for holding an absorbent applicator such that a portion of the applicator is extending beyond the plunger and a portion of the applicator extends below the plunger into the container base.

Abstract: A strip like structure is formed in the shape of a succession of phials, of a heat-sealable plastic, with the phials molded with their respective bases open and their mouths each closed by a removable stopper element, each of the phials having a first set of webs disposed transversely about the middle of their respective longitudinal axis and a second set of webs formed at the mouth ends with narrow stiffening ribs on either side of an uppermost edge thereof, the first and second webs serving to interconnect the phials and the removable stopper elements closing the same, respectively. The interconnecting webs are provided with relative weakening creases located preferably midway between each two adjacent phials and disposed parallel to the phial longitudinal axis. Each terminal web of the second set has transverse butt portion disposed at right angles to the plane of the web, the butt having a width not greater than the width of the phial and a height equal to a depth of the second web.

Abstract: Method and apparatus for sealing gelatin capsules having cylindrical cap and body portions arranged in telescoping relationship to contain a medicament therein comprising a capsule-sealing machine for continuously conveying capsules from a supply hopper to a capsule-rectification station wherein the capsules are reoriented and delivered in endwise, cap-down abutment to capsule-wetting stations where a suitable sealing liquid is applied to the capsules at the seams of their cap and body portions to be located between the overlapping side walls of the cap and body portions of the capsules, and wherein the capsules are conveyed from their wetting stations in peripheral pockets of a rotating drum dryer to a capsule heating and sealing section where the capsules are heated by convection and conduction to seal the cap and body portions.

Abstract: A hard shell tamper-proof capsule having cylindrical, telescopically joinable, coaxial cap and body parts each having a side wall, an open end and a closed end, the cap and body being adapted to be mutually joined; characterized in that the body closed end has either a generally hemispheroidal, a pyramidical, a conical or a flat outside surface, and that the body side wall is totally enclosed within the cap side wall thereby exposing only the outside surface of the body closed end for gripping, which impedes separation of and tampering with the joined capsule.For additional security the tamper-proof capsule may be provided with locking means of circumferentially extending ridges or grooves.For further security the tamper-proof capsule may be provided with sealing means such as hot water, steam, or hot solutions or emulsions.

Abstract: A package for shipping, storing and controlled dispensing of a unit or single use quantity of liquid comprises a pair of flexible, liquid-impermeable sheets superposed one over the other. Each of the sheets comprises a first substantially rectangular section and a second substantially rectangular section, having different widths, and a transition section interconnecting the other two sections. One of the sheets has a recess formed therein which defines a pocket receivable of a unit or single use quantity of liquid. The other sheet defines a cover extending across and covering the recess. The recess also includes a portion defining an elongated and narrow spout extending outwardly of the pocket. The sheets are hermetically sealed to one another about their periphery completely about the recess. The "seal" may be manually peeled back in the region of the spout to open the package.

Abstract: A message device including a planar panel, a waterproof cup defining an enclosure having an outwardly extending flange and an open end where the flange is adapted to be attached to the panel with the open end adjacent the panel and the enclosure extending through an opening where the cup is adapted to receive a water soluble capsule containing a expanable material cut in the shape of a message so that the capsule melts when it is exposed to water and allows the message piece to expand.

Abstract: Dispensing packs which contain chambers with at least two solid, not mechanically connected dosage units of various pharmaceuticals.

Abstract: The present invention relates to a method for sealing capsules to render them both tamper-proof and tamper-evident. The method comprises locating a quantity of an adhesion-promoting fluid between the adjacent surfaces of the overlapping capsule wall, and thereafter applying dielectric heat energy in the vicinity of the adhesion-promoting fluid, to cause the adjacent surfaces of the capsule walls to form a permanent bond. Preferably, the adhesion-promoting fluid may comprise a non-solvent for the capsule walls that further has a high dielectric constant. Suitable adhesion-promoting fluids include lower alkanols. The method is capble of rapid operation and is inexpensive by virtue of its simplicity. Reliable capsule seals are achieved that are incapable of violation.

Abstract: A medicinal capsule comprising a cap member containing a first circumferential slot formed on the outer surface of the upper portion, at least one raised member formed on the inner surface of the cap, a body member containing a second circumferential slot formed on the outer surface of the upper portion thereof for slidably locking with the first circumferential slot of the cap member during final locking, and at least one connecting member formed on the outer surface of the second circumferential slot of the body member and extending internal to the body member for slidably locking with the raised member of the cap member, the raised member and the connecting member being dimensional relative to each other so as to form a space therebetween whereby when the cap member and body member are preliminarily locked prior to final locking, the capsule is not deformed.

Abstract: Improved method and apparatus for use in sealing gelatin capsules filled with medicinal ingredients wherein each capsule has a generally cylindrical cap and body arranged with the side wall of the body telescopically within the side wall of the cap to contain the medicament therein comprising an economical and compact wetting device for automatically conveying filled capsules from a capsule-filling machine by pneumatic pressure conveyance through one or more passageways to a wetting location where each capsule is maintained in a generally cap-upright position and metered amounts of a wetting liquid are applied to side wall portions of the body of the capsule adjacent the seam of the cap and body to pass by capillary action into the space between the overlapping cap and body side walls, and the capsules are released from wetting positions in the passageways for further pneumatic conveyance to a point of heat treatment for final sealing of the body and cap portions of the capsule to prevent their separation and

Abstract: Methods are disclosed for the sealing of gelatin capsules having coaxial cap and body parts which overlap when telescopically joined. Also described are apparatus and denaturation-melting point depression mixtures to seal the capsules.

Abstract: The two halves of medicine-filled, gelatin capsules are fitted together and passed through a field of microwave energy to selectively melt the overlapping portions of the two halves whereby they become sealed together when the capsules are removed from the microwave energy field and permitted to cool.

Abstract: This invention provides oral dosage forms of therapeutic agents such as digestive enzymes which are subject to degradation and loss of activity at gastric pH. and compositions and methods for preparing same. Capsules of their components are formulated from a composition comprising a plastic homogeneous mass of gastric fluid impervious material such as cellulosic derivatives or collagenous material; from 10-65% by weight of a diluent selected from the group consisting of water, a lipid having a melting point above mammalian body temperature and a water miscible solvent; 4-60% by weight of procollagen; and 30-86% by weight of collagen or elastin. The composition is formed into finished capsules of relatively homogeneous composition comprising 10-50% by weight of procollagen and 40-96% by weight of a material selected from the group consisting of collagen and elastin, and having less than 4% by weight of fat and water-soluble protein.

Abstract: A hard shell capsule for the exact dosage of substances, especially for pharmaceutical use, having a body part and a cap part which is joinable with said body. The body part has a side wall, a closed end and an open end. The cap part is die-molded or extruded as a stopper directly into the open end of the body after the body has been filled, so as to seal the contents within the capsule.

Abstract: A pill container having a body with a cavity for receiving a pill formed therein, a cover slidably arranged on the body to cover the cavity being retained in cavity covering position by the mating arrangement of the body and cover, the cover being further arranged to be moved by engagement of the cover with the teeth of a user, and movement of the body inwardly of such user's mouth to position the cavity therewithin permitting a pill to drop from the cavity, into the user's mouth as the pill will provide the necessary reaction sought.

Abstract: Methods and apparatus for bonding an overlapping portion of the outer cap (7,7') and inner body (6, 6') of a closed cylindrical capsule (5). A flexible tubular coupling (13,14,20) positioned around the circumference of the capsule (5) is compressed to exert an inward radial force (23) on the capsule (5) while ultrasonic vibratory motion is applied in a direction (12,12') parallel to the axis of the capsule (5) by an ultrasonic transducer (10,10') with a rigid tip (11,11') attached to the coupling (13,14,20). For bonding of gelatinous capsules (5), the unitary coupling (20) or split coupling (13,14) can comprise a polymeric elastomer material such as latex rubber with approximately the same acoustical impedance as the capsule (5).

Abstract: A capsule-sealing apparatus for use in conjunction with capsule-filling equipment is disclosed which seals a two-piece ingestable capsule. The sealing apparatus includes a chamber having nozzles for dispensing the contents of the chamber, the chamber being supplied with hot, moist air of controlled consistency, preferably being achieved by mixing a supply of steam and air in appropriate proportions. The average pressure of the chamber is maintained slightly below that of the ambient atmosphere which acts to prevent the hot, moist air from leaving the chamber through the nozzles. Apparatus is provided for causing a momentary increase in the pressure within the chamber, which increase delivers the hot, moist air from the chamber through the nozzles into cap members adjacent thereto. The caps thereafter telescopically receive a filled body member of the gelatin capsule, a bond forming between the cap member and body member of the capsule upon their being joined.

Abstract: Methods are disclosed for the sealing of gelatin capsules having hard shell coaxial cap and body parts which overlap when telescopically joined. Also described are apparatus and sealing fluids to seal the capsules.

Abstract: A container in the form of a packaging having at least one supporting or receptacle part such as for medicaments or the like, which if necessary or desired are contained in a separate medicament vessel and a lid which is slidable on guiding strips on the receptacle part. The slidable engagement of the lid and receptacle is effected by longitudinal edge portions on the lid or receptacle engaging in grooves on the other part. At opposite ends of the container, flaps made at least in part of flexible or reversible material are provided and, when the container is closed serve as stops which restrict relative movement between the lid and the receptacle. The flaps may be bendable, or removable or contain projections which may engage in recesses when the container is closed.

Abstract: A self-locking, tamperproof capsule comprising hard gelatin body and cap members having essentially cylindrical sidewalls that telescopically engage to form the capsule, wherein the annular side of the telescopically engaged cylindrical surfaces contain a plurality of concentric saw-toothed protrusions that allow the filled capsule body and cap to be assembled, but prevents subsequent disassembly.

Abstract: An apparatus for the application of controlled combinations of temperature, vacuum, pressure and time to seal capsules is disclosed. Also described are methods to seal capsules and to enhance the bonding of the sealed capsules.

Abstract: Capsules (10) such as used for administering medicines, foods, and the like, are formed by a pair of sections (12, 14) locked to one another by a latching assembly (28) including a projecting member (30) provided on one of the sections and a keeper or abutment (34) provided on the other of the sections. By this arrangement, the projecting member and the abutment will snap together when the associated sections are matingly joined so as to resist separation.

Abstract: A method is disclosed for sealing edible capsules comprised of telescopically engaged tubular capsule halves that define a junction seam between them. The method comprises adhesively applying against at least a portion of the seam a frangible, edible label adapted to cover the seam at the point of intersection therewith, and to fracture upon slight displacement of the capsule halves with respect to each other. In one embodiment, the present method comprises the preparation of individual labels, the application to such labels of a quantity of adhesive and the subsequent application of the labels to the capsule. In an alternate embodiment, the labels, comprising a film forming material, are directly applied to the capsule by the projection of a hot melt of the film forming material onto the capsule at the location of the seam.

Abstract: A capsule for housing pellets is disclosed having two members, the first with a raised portion and the second with a connecting groove and an annular groove for interconnection with the raised portion to secure the two members together.

Abstract: An ample case is made of a base sheet folded into a rectangular form when seen in side elevation. Ampules are accommodated in the case, being spaced side by side at with the bottoms of the ampules adhering to the bottom wall of the case. When an ampule is to be used, a segment of the base sheet is separated off with the ampule attached thereto along a severance line formed in the base sheet between adjacent ampules. A side wall of the case bears the name of the preparation in the ampules and like required information, thus eliminating the necessity of printing or labelling the ampules individually.

Abstract: A package is provided for supporting tablets, capsules, pills or the like. The package is formed by a disc having cut-out portions in which the tablets are placed and are held by two coatings covering each of the faces of the disc. An aperture is formed in the center of the disc intended for the introduction of the disc onto the neck of a bottle. In the alternative the support disc is constructed of two specially concentric members in which the tablets are placed and retained by two coatings applied to each face of the members. The tablets are easily removed by exerting a slight pressure on one of the sides of the disc to expel the tablet by tearing a sheet of coating.

Abstract: A prdetermined amount of toothpaste sufficient for a single brushing of the teeth is encapsulated with a covering which is easily storable, non-toxic and easily breakable when chewed or bitten.

Abstract: A package for containing a preselected amount of a product in the form of a pill or the like is adapted to be converted for use as a cup for containing liquid and includes a pair of sidewalls made of paperboard which are joined together along three mutual edges thereof, the fourth mutual edges defining the top of the cup. A support flap is connected by a perforated score line along an edge of one of the sidewalls at the top of the cup and has a plastic blister bonded to one face thereof within which a pill or other product may be contained. The support flap is provided with an aperture therein registering with the interior of the blister and a frangible closure, preferably a metal foil, is secured in overlapping relationship to the aperture to prevent loss of the product prior to the time of use. Spaced fold lines in the sidewalls allow folding of the package to a compact condition for storage, and the support flap may be torn away from the top of the cup during use to allow ready access to the product.

Abstract: A method is proposed providing push-through containers with removable stickers making possible a simple and sure affixing of the stickers to the push-through containers. In addition, this method has the further advantage of making possible the simple and easy removal of the sticker from each container unit separated from the push-through container.

Abstract: A liquid dispensing package from two continuous abutting strips having opposed recesses provided with spaced holes and forming substantially cylindrical chambers for individual ampoules. The strips are heat sealed together and non-woven fabric is heat sealed to the outer sides of said strips. Individual liquid dispensing packages are die-cut from strips with each having a peripheral flange. The liquid dispensing package can be manually crushed whereby the liquid in the ampoule penetrates through said fabric.

Abstract: An elongated, two-piece, hardshell, digestible gelatin capsule, to be taken orally, comprising a C-shaped body member into which may be inserted a liquid, and a digestible hard-shell gelatin cap member formed with a stepped free marginal edge portion complementary to the body member, telescopically registrable with the free upper end of the body and welded thereto in overlapping hermetically sealing, closing relation.

Abstract: An elongated, two-piece, hardshell, digestible gelatin capsule, to be taken orally, comprising a C-shaped body member into which may be inserted a liquid, and a digestible hard-shell gelatin cap member formed with a stepped free marginal edge portion complementary to the body member, telescopically registrable with the free upper end of the body and welded thereto in overlapping hermetically sealing, closing relation.

Abstract: Apparatus for manufacturing pharmaceutical single-dose containers with opening threads, including a thread introduction device in conjunction with a presealing station, where the thread introduction device is mounted so as to be movable in the direction of the presealing station and comprises thread transporting means, thread cutting means and time synchronization control means for the individual devices in such a way that first the foil strip is advanced by a particular unit, then the thread introduction device is moved in the direction of the presealing station and the threads are introduced into a number of single dose containers, followed by the sealing of the halves of the single-dose containers in adjacent areas with simultaneous sealing of part of the threads, and finally the threads are cut from the thread strand or the pre-cut threads are taken from the guide channel, whereupon the thread introduction device is moved out again and the foil strip is transported further.

Abstract: A method is described for joining a capsule having a body and a cap comprising the steps of telescoping the cap onto the ridge of the body part, applying a pasty solidifying sealing composition onto the inner side of the capsule in the form of a strand, in the area of the ridge.

Abstract: A method is provided of manufacturing a joined telescoping vented cap-and-body capsule filled with viscous material, comprising the steps of filling the viscous material into the body part, closing the filled body part with a layer of pasty sealing composition which is inert to the viscous material, telescoping the cap and closed body part, and sealing the inner side of the cap to the body part.

Abstract: The specification discloses a process for packaging stain remover in individualized gelatine capsules whose exterior surfaces are treated with a solution of a water insoluble plastic material, specifically from about 5 to about 20 parts of post chlorinated polyvinyl chloride per 100 parts of finished solution, in a chlorinated hydrocarbon solvent selected from the group consisting of chloroform, methylene chloride, dichloroethane, trichloroethane, trichloroethylene and combinations thereof.

Abstract: Containers for storing various pills are provided which have excellent water vapor permeation resistance and which includes child-resistant opening features. The container includes a top and a bottom which are adapted for telescopic positioning with respect to each other in a generally flush-like manner so that edge exposures are kept to a minimum and the top and bottom each include means which are brought into inter-engagement to define a sealed internal chamber for storing tablets, such as aspirin. Wall portions of the top and bottom are configured to preclude opening of the container except by exertion of a compressive force at selective locations. Such selective application of compressive force between the top and the bottom allows the top to be removed from the bottom in a generally pivotal lever-like manner about a hinge connection by the engagement of a fulcrum surface on the bottom with the internal surface of a portion of the top.

Abstract: Each sheet-form layer of plastic film to be superposed with another layer between layers of non-heat conducting material, such as paperboard, is perforated in a pattern such that, when the layers of plastic are superposed between the layers of normally non-heat conducting material for heat sealing, the perforations of each layer of plastic are aligned with imperforated portions of the superposed perforated layer of plastic. When sealing heat and pressure are applied to the superposed layers of plastic and paperboard or the like by conventional heated dies, each layer of plastic is rapidly sealed to the inner surface of both layers of paperboard, or, if initially sealed to the inner surface of one layer, is rapidly sealed directly to the inner surface of the other layer of paperboard.

Abstract: A medical alert bracelet for carrying an emergency supply of a patient's medicament comprising a bracelet strap and a blister package containing a medicament form. The blister package is held in the bracelet strap, a hole is formed in the bracelet strap beneath the blister package for push-through ejection of the medicament from the bracelet, and a closure is provided for closing the strap onto the wrist of the patient. A weakened line is positioned across the strap and is easily ruptured to remove the strap from the patient's wrist, and a locator notch is provided at the weakened line so that it is easily located, even in the dark. The invention also includes a method of making the medical alert bracelet.

Abstract: A hard gelatin capsule, especially for medicaments, having a cylindrical body and a cylindrical cap that telescopes over the open end of the body in which the interior surface of the cap, which overlaps the body, is provided with toothlike projections spaced around the circumference thereof to lock the body and cap against relative axial and rotational movement. In a preferred form of the invention the projections have gently-sloping side walls in both the lateral (circumferential) and longitudinal (axial) directions, which facilitate removing the cap from the dipping pin on which it is formed.

Abstract: In a pressurized packing container having an inner tubular container of plastic material and an outer casing of non-elastic material, which tubular container, after being filled, is to be sealed off along two transverse seals spaced from one another, an improved sealing is realized by causing the transverse seals to have a curved or angled contour at at least one of their end points.

Abstract: A quick-opening package comprises a layer of formable material, at least one pocket in the formable layer, and a frangible backing layer adhered to the formable layer for enclosing an item contained in the pocket. An arrangement is provided for strengthening portions of the formable layer, and the strengthening arrangement defines an angulation fold line extending between the formable layer portions and across the pocket. A layer of protective material is adhered at least peripherally to a side of the frangible layer opposite from the formable layer. The protective layer has a line of weakening therein extending adjacent to and generally parallel with the fold line of the package.

Abstract: Methods are disclosed for the sealing of gelatin capsules having hard shell coaxial cap and body parts which overlap when telescopically joined. Also described are apparatus and sealing fluids to seal the capsules.