Chromatography Patents (Class 210/198.2)
  • Patent number: 10677793
    Abstract: A method for providing a lateral flow of liquid across a plurality of microwells of a microfabricated device. The microwells of the microfabricated device are covered by a membrane which includes a first portion disposed on one side of at least one microwell and a second portion on the other side of the at least one microwell. The first portion of the membrane is contacted with a liquid absorbable by the membrane such that the liquid is wicked by the membrane and laterally flows from the first portion to the second portion and across the at least one microwell. At least a portion of the liquid enters the at least one microwell.
    Type: Grant
    Filed: June 27, 2017
    Date of Patent: June 9, 2020
    Assignee: GENERAL AUTOMATION LAB TECHNOLOGIES INC.
    Inventor: Alexander Hallock
  • Patent number: 10675558
    Abstract: A dispersed mobile-phase countercurrent chromatography system is described in which solutes are carried by a stream of dispersed mobile phase solvent through a column, or array of serially-connected columns, of stationary phase solvent with which the mobile phase solvent is immiscible. Solutes carried along by the stream of dispersed mobile-phase solvent will be equilibrated between the mobile-phase solvent and the stationary-phase solvent. Because the mobile-phase is dispersed into mini-droplets much smaller in diameter than the column of stationary phase, the enhanced surface/volume ratio of the droplets expedites countercurrent equilibration of different solutes between the mobile-phase solvent and the stationary-phase solvent in accordance with the distribution-coefficients of the solutes between the two solvents.
    Type: Grant
    Filed: April 14, 2017
    Date of Patent: June 9, 2020
    Assignee: The Hong Kong University of Science and Technology
    Inventors: Yiu Cheong Ho, Jeffrey Tze Fei Wong, Hong Xue
  • Patent number: 10669174
    Abstract: A water purification device is provided in the form of a hydrogel matrix containing immobilized nanoparticles that are directly synthesized in-situ in the hydrogel matrix. The hydrogel matrix is temperature sensitive, such that swelling draws in pollutants that are captured by the nanoparticles, while deswelling releases purified water. A related method of decontaminating the water supply contaminated with a target pollutant is also disclosed.
    Type: Grant
    Filed: April 3, 2012
    Date of Patent: June 2, 2020
    Assignee: THE UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Dibakar Bhattacharyya, Li Xiao
  • Patent number: 10668406
    Abstract: The present disclosure relates to an enhanced multi-dimensional chromatography system and method using selectable At-Column Dilution to improve compatibility of the interface and transfer between the multiple dimensions. The use of At-Column Dilution (“ACD”) with multi-dimensional chromatography can provide greater retention of the diverted components on subsequent stationary phases, and increase the sensitivity and peak shape of the component(s) separated on subsequent dimensions.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: June 2, 2020
    Assignee: Waters Technologies Corporation
    Inventors: Amanda B. Dlugasch, Thomas E. Wheat, Dan Root, Jean-Michel Plankeele, Isabelle Francois, Edward R. Aig
  • Patent number: 10661219
    Abstract: A method for separating N2 from a hydrocarbon gas mixture containing N2 comprising the steps of: i) providing a bed of adsorbent selective for N2; (ii) passing the hydrocarbon gas mixture through the bed of adsorbent to at least partially remove N2 from the gas mixture to produce: (a) N2-loaded adsorbent and (b) N2-depleted hydrocarbon gas mixture; iii) recovering the N2-depleted hydrocarbon gas mixture; iv) regenerating the N2-loaded adsorbent by at least partially removing N2 from the adsorbent; and v) sequentially repeating steps (ii) and (iii) using regenerated adsorbent from step (iv); wherein the adsorbent comprises a pyrolized sulfonated macroporous ion exchange resin.
    Type: Grant
    Filed: January 6, 2016
    Date of Patent: May 26, 2020
    Assignee: DDP SPECIALTY ELECTRONIC MATERIALS US, INC.
    Inventors: Junqiang Liu, Chan Han, H. Robert Goltz, Matthew L. Rodgers, Scott T. Matteucci, Brandon J. Kern
  • Patent number: 10662648
    Abstract: Gypsum board having a core, said core having at least one side covered with a non-woven fabric; characterized in that the inner side of the non-woven fabric, which is in contact with the core of the gypsum board, has a surface roughness Ra of from 25 to 60 micrometers, preferably from 25 to 50 micrometers, advantageously from 25 to 40 micrometers.
    Type: Grant
    Filed: December 26, 2012
    Date of Patent: May 26, 2020
    Assignee: Ahlstrom-Munksjö Oyj
    Inventors: Emmanuel Faynot, Marc Berlioz, Samuel Merlet, Claude Leclercq
  • Patent number: 10654025
    Abstract: The core-shell type amine-based carbon dioxide adsorbent including a chelating agent resistant to oxygen and sulfur dioxide according to the present invention is an adsorbent which includes a chelating agent to inhibit oxidative decomposition of amine and has, as a core, a porous support on which an amine compound is immobilized and has, as a shell, an amine layer resistant to inactivity by sulfur dioxide, and a method of preparing the same. The amine-based carbon dioxide adsorbent including a chelating agent exhibits considerably high oxidation resistance because an added chelate compound functions to directly remove a variety of transition metal impurities catalytically acting on amine oxidation. In addition, the sulfur dioxide-resistant amine layer of the shell selectively adsorbs sulfur dioxide to protect the amine compound of the core and, at the same time, the amine compound of the core selectively adsorbs only carbon dioxide.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: May 19, 2020
    Assignee: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Minkee Choi, Woosung Choi, Chaehoon Kim
  • Patent number: 10641747
    Abstract: The subject technology is directed to a CO2-based chromatography system and method for rapid determination of the levels and/or the presence or absence of polymer additives (PAs) leachable or extractable from packing materials or implantable medical devices.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: May 5, 2020
    Assignee: Waters Technologies Corporation
    Inventors: Stephane Dubant, Baiba Cabovska, Andrew Aubin, Michael Jones, Peter Hancock
  • Patent number: 10643830
    Abstract: A sample introduction unit 2 regularly collects a sample from a sample passage 1. A measurement unit 3 performs an LC/MS analysis for the collected sample. A spectrum matching judgment section 42 performs image recognition referring to mass spectra in a normal condition accumulated in a normal spectrum database 44, to determine whether a measured mass spectrum is in a normal condition. If the mass spectrum is non-normal, an abnormal peak locator 45 locates a peak which should not be detected in the normal condition, and an MSn analysis with the located peak selected as the target is performed in the measurement unit 3 under an MSn analysis execution commander 46. An identification processor 47 performs substance identification by a library search based on an acquired MSn spectrum. Upon successful identification, an alert commander 49 issues an alert. Thus, the system can automatically monitor hazardous substances with high accuracy.
    Type: Grant
    Filed: October 12, 2018
    Date of Patent: May 5, 2020
    Assignees: SHIMADZU CORPORATION, National Institute for Environmental Studies
    Inventors: Toshikazu Minohata, Shoji Nakayama
  • Patent number: 10626452
    Abstract: An object of the present invention is to provide a method for accurately and quantitatively discriminating and detecting a wide variety of gene mutations, or particularly, single base substitutions or point mutations. In an ASP for analyzing gene mutations, or particularly, single base substitutions or point mutations, when a non-nucleotide component is added to the 5? end of at least one of the ASP and a primer paired therewith before amplification by PCR and amplification products thereof are separated by ion-exchange chromatography, even the amplification products having the same length can be separated and detected.
    Type: Grant
    Filed: September 29, 2017
    Date of Patent: April 21, 2020
    Assignee: SEKISUI MEDICAL CO., LTD.
    Inventors: Hiroyuki Ebinuma, Katsura Uchida, Yuriko Tsukamoto
  • Patent number: 10627374
    Abstract: Systems, apparatuses, kits, and methods for purification and analysis of analytes having a broad range of hydrophobicities by liquid chromatography-mass spectrometry (LC-MS). Using one set of liquid chromatography columns, one set of mobile phase buffers, and, optionally, a single ionization method (e.g., electrospray ionization), a wide range of analytes can be purified and analyzed on a liquid chromatography-mass spectrometry (LC-MS) system. LC-MS purification and analysis of analytes having a broad range of partition coefficients is accomplished by selecting LC run parameters and MS system parameters that are particular to different classes of analytes without having to make column or buffer changes or any other hardware configuration changes to the LC-MS system.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: April 21, 2020
    Assignee: Cohesive Technologies Inc.
    Inventors: Joseph L. Herman, Robert Dewitte, Dayana Argoti
  • Patent number: 10610806
    Abstract: The object of the invention relates to an extraction cell (100) used in a centrifugal partition chromatograph, which has a cell wall (120) determining a closed extraction chamber (150), as well as an inlet (115) and an outlet (140) ensuring the fluid connection between the extraction chamber (150) and the space outside of the extraction cell (100) formed on essentially opposite parts of the cell wall (120). The extraction cell (100) according to the invention is constructed asymmetrically from the point of view of the reversibility of the direction of flow used when the centrifugal partition chromatograph is in operation.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: April 7, 2020
    Assignee: ROTACH ROM TECHNOLOGIAI KFT.
    Inventors: Laszlo Lorantfy, Laszlo Nemeth
  • Patent number: 10613503
    Abstract: A fraction collection system includes one or more chromatography columns. The system also includes one or more fraction collectors for collecting effluent from the columns. The fraction collectors include several racks, each holding a set of collection receptacles. A control system interfaces with the fraction collectors to implement experiments. The control system provides a user interface with which users can schedule runs. The user interface includes a graphical representation of the racks and tubes of the fraction collectors. Users can schedule runs to groups of tubes, and a visual attribute of the representation of the tube in the user interface is updated to indicate that the tubes are assigned to a run.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: April 7, 2020
    Assignee: Bio-Rad Laboratories, Inc.
    Inventor: Kevin Thornton
  • Patent number: 10613061
    Abstract: In a chromatography system, including within the system an extraction vessel which receives a mixture of mobile phase and co-solvent and provides a mixture of mobile phase and co-solvent with sample to a chromatography column to increase sample concentration within the mixture. In addition, adding a reservoir to the chromatography system to form an extraction-pressurization system, wherein the mixture with sample may be collected in the reservoir and may diffuse and equilibrate to an approximately uniform sample concentration before being provided to the chromatography column. Also in addition, providing a plurality of extraction-pressurization systems to allow near-simultaneous extraction of sample and loading of the column, or concurrent extraction and loading by the plurality of extraction-pressurization systems.
    Type: Grant
    Filed: January 19, 2017
    Date of Patent: April 7, 2020
    Assignee: Waters Technologies Corporation
    Inventor: Abhijit Tarafder
  • Patent number: 10603645
    Abstract: Exemplary embodiments are directed to a diffuser assembly configured to be disposed in an extraction path of an extracting solvent in an extraction vessel. The diffuser assembly includes a housing configured to be disposed within the extraction vessel, the housing including an inner surface and an outer surface. The diffuser assembly includes an inlet structure disposed within the housing. The diffuser assembly includes an outlet structure disposed within the housing and spaced from the inlet structure to form a mixing chamber between the inlet structure and the outlet structure. The inlet structure and the outlet structure each have a porosity configured for passage of the extracting solvent therethrough. Passage of the extracting solvent through the inlet structure, the mixing chamber, and the outlet structure redistributes flow of the extracting solvent along the extraction path.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: March 31, 2020
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventors: Michael Webster, David Sauers, Curt White, Steven Stricko
  • Patent number: 10607722
    Abstract: Provided is a system for helping an operator determine the target ion, collision energy and other analysis conditions. A chromatogram selected by an operator is displayed in a chromatogram display area of an MRM measurement parameter determination window. When the operator selects a point on this chromatogram, the name of a target compound which is registered in an event linked with a range of time including the selected point in time is displayed on a compound name display area. A plurality of mass spectra collected at that point in time are also displayed in a mass spectra display area in a vertically arranged form, using the same scale on the mass axis and the same scale on the intensity axis, with the scales of their mass axes aligned with each other in the vertical direction. The operator can then check whether the selected peak corresponds to the target compound.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: March 31, 2020
    Assignee: Shimadzu Co.
    Inventor: Tomohiro Kawase
  • Patent number: 10605792
    Abstract: Provided are a method of and an apparatus for formulating a multicomponent drug capable of surely making a multicomponent drug meeting criteria for productization with high accuracy into a product. The method and apparatus obtain a chromatogram from an extract or a base of a multicomponent drug, evaluate whether the base meets the criteria for productization based on the obtained chromatogram with high accuracy, and subject the base determined in the high-accuracy evaluating as an accepted one meeting the criteria to dosage form processing, to produce a formulated drug having a given dosage-form. The high quality evaluation is realized by using fingerprint area segmentation feature values obtained from a fingerprint formed from a chromatogram and segmented into a plurality of areas.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: March 31, 2020
    Assignee: Tsumura & Co.
    Inventors: Shoichi Teshima, Yoshikazu Mori, Keiichi Noda
  • Patent number: 10603604
    Abstract: A slurry chamber is fastened to and held in coaxial alignment with a chromatography column by a V-band. One end of the column has an end cap and frit. A slurry of fluid and chromatographic media is placed in the column and chamber. A piston is forced through the chamber and into the column by a hydraulic ram to expel the fluid and form a media bed in the column. The slurry chamber is removed, and a split end cap is fastened to the column. A threaded recess in the split end cap receives a split, threaded collet. The collet is tightened until it pushes against the piston with the same force as the ram, at which point the ram is released and the column removed for use.
    Type: Grant
    Filed: July 19, 2017
    Date of Patent: March 31, 2020
    Assignee: Phenomenex, Inc.
    Inventors: Peter C. Rahn, Romaine R. Maiefski, Tivadar Farkas, Emmet E. Welch
  • Patent number: 10598676
    Abstract: Methods are described for determining the amount of metabolites of leflunomide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying teriflunomide in a sample.
    Type: Grant
    Filed: October 11, 2017
    Date of Patent: March 24, 2020
    Assignee: Quest Diagnostics Investments Incorporated
    Inventor: Karin O. Thomassian
  • Patent number: 10598640
    Abstract: The invention discloses a method for correcting a baseline in a chromatogram obtained using a buffer with at least one UV-absorbing component which is a weak acid or a weak base.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Gunnar Malmquist, Martin Hall, Nils Stafstrom
  • Patent number: 10598638
    Abstract: A chromatography lab system comprising a cooling compartment arranged to hold both fraction collector devices and sample containers, whereby the cooling compartment comprises an identifying device which is arranged to identify the fraction collector devices such that fractions from the chromatography are collected only in the fraction collector devices.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: March 24, 2020
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Bjorn Olovsson, Karol Lacki, Mikael Berg
  • Patent number: 10590607
    Abstract: The present invention relates to an interpenetrating polymer network (IPN) material comprising microcrystalline cellulose (MCC), microfib-rillated cellulose (MFC) or a mixture thereof, and at least one polymer forming an IPN together with the MCC, MFC or mixture thereof. The present invention further relates to a process for producing the IPN material, and to use of the IPN material in paper industry.
    Type: Grant
    Filed: December 3, 2015
    Date of Patent: March 17, 2020
    Assignee: Kemira Oyj
    Inventors: Rosa Carceller, Tom Lundin, Matti Hietaniemi
  • Patent number: 10590161
    Abstract: The current landscape for preparative chromatographic RNA purification uses reversed phase HPLC, but this technique presents many issues with process scale up and ion exchange for preparative purification has only been used for short RNAs. The invention provides preparative purification of RNA (e.g., mRNA) using ion (e.g., anion) exchange chromatography that allows for separation of longer RNAs up to 10,000 nucleotides in length via a scalable method. This method avoids problems with current techniques by using low pressure chromatography that is agreeable with existing equipment in cGMP commercial facilities, that uses aqueous-bases solutions as the mobile phase (rather than flammable of greater than 10 mg RNA/mL resin (e.g., using larger pore sorbents, >500 Angstroms, that display greater mRNA binding capacities), and that yields desired RNA salt forms for downstream formulation with no additional manipulation necessary (unlike ion pair reverse phase techniques).
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: March 17, 2020
    Assignee: ModernaTX, Inc.
    Inventors: William Joseph Issa, Joseph Louis Barberio, John Grant Aunins, Noubar B. Afeyan
  • Patent number: 10591452
    Abstract: A gas chromatograph is provided which is capable of effectively reducing the amount consumed of a carrier gas, reducing the time and effort required for an operator to manually set parameters, and preventing damages to a column and a detector due to a setting mistake. In a case where a stop operation for the power supply of the gas chromatograph is performed (Yes in step S101), the flow rate of a carrier gas to be supplied to a sample vaporization chamber is decreased and the temperatures of the column and the detector are sufficiently lowered (steps S102 to S104), and then the power supply of the gas chromatograph is switched over from an ON state to an OFF state (step S106).
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: March 17, 2020
    Assignee: SHIMADZU CORPORATION
    Inventor: Maki Saito
  • Patent number: 10585071
    Abstract: A multidimensional chromatographic assembly includes a pump module, an injector, a path selector device, an array of chromatographic media, a loop selector device and a detector assembly for receiving at least a portion of an analyte stream and flowing the injected stream into the detector assembly via a chromatographic medium (the first dimension). At least a portion of the analyte of interest is then channeled into a chromatographic medium of interest (the second dimension) and re-circulated through the detector assembly. The iteration (multidimension) is continued until all aspects of the chromatogram and the peaks are judged to be analyzed. The entire process is controlled from a computer and the results are collected to make decisions on the analytical and the process controls.
    Type: Grant
    Filed: November 10, 2016
    Date of Patent: March 10, 2020
    Inventors: Michael Organ, Debasis Mallik
  • Patent number: 10583432
    Abstract: A sampling module of a fluid processing apparatus includes at least one multi-configuration device connected to a filtration module. The invention relates to an area of non-disruptive sampling from any flow stream including the ones containing solids. The fluid processing apparatus remains in fluid communication with a sample processing module in all configurations of the sampling module and the parameters deemed critical for a chemical process remain unaffected during the sampling event. The entire event is controlled from a computer and the results are collected to make decisions on analytical and process controls.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: March 10, 2020
    Inventors: Michael Organ, Debasis Mallik, Jee Seong Kwak
  • Patent number: 10577259
    Abstract: A cerium (IV) oxide composition having unexpectedly greater arsenic loading capacities than oxides of cerium (IV) of the prior art are disclosed. The arsenic loading capacities are greater at low level equilibrium levels of arsenic. The cerium (IV) oxide composition is more effective at removing arsenite and arsenate. Moreover, the cerium (IV) oxide composition has a greater capacity for the previously more difficult to remove arsenite.
    Type: Grant
    Filed: April 9, 2018
    Date of Patent: March 3, 2020
    Assignee: Secure Natural Resources LLC
    Inventors: Dimitrios Psaras, Yuan Gao, Mason Haneline, Joseph Lupo, Carol Landi
  • Patent number: 10571440
    Abstract: A two-dimensional liquid chromatographic analyzer, in which a temperature control part changes a temperature in a single-step manner and switches the temperature at a high speed. Also, the temperature control part has a holder around a separation column so that the temperature of the separation column can be changed to a preset temperature. A first separation column thereof changes elution time(s) of the objective component(s) by temperature modulation and the mobile phase of the first separation column is an aqueous mobile phase having a constant composition.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: February 25, 2020
    Assignee: HITACHI HIGH-TECH SCIENCE CORPORATION
    Inventors: Katsutoshi Shimizu, Hideko Kanazawa
  • Patent number: 10571374
    Abstract: A method of extracting an analyte from a sample is described. The sample is added to a sample container. A liquid solvent and a gas are added into the sample container. The addition of the gas is controlled to establish an elevated pressure within the sample container. The liquid solvent is heated to an elevated temperature that is below the boiling temperature of the liquid solvent at the elevated pressure. A type of gas is used that does not transition to a supercritical fluid at the elevated temperature and pressure used in the extraction process. The analyte can dissolve from the solid sample into the liquid solvent. Next, at least a portion of the liquid solvent containing the dissolved analyte can be removed from the sample container for subsequent analysis.
    Type: Grant
    Filed: August 10, 2016
    Date of Patent: February 25, 2020
    Assignee: Dionex Corporation
    Inventors: Kannan Srinivasan, SM Rahmat Ullah
  • Patent number: 10562007
    Abstract: The present invention relates to a separation matrix, which comprises a support; extenders coupled to an outer part of said support; and ligands coupled to said extenders, wherein the part of the support to which the extenders are coupled constitutes less than 50% of the volume of the separation matrix. The invention also embraces a method of preparing such a separation matrix, as well as a process wherein the separation media is used.
    Type: Grant
    Filed: July 22, 2008
    Date of Patent: February 18, 2020
    Assignee: GE Healthcare BioProcess R&D AB
    Inventors: Andreas Axen, Jan Bergstrom, Gunnar Glad, Bo-Lennart Johansson, Nils Norrman
  • Patent number: 10562026
    Abstract: A device, especially a microfluidic device for performance of an immunoassay, has a first, a second and a third fluidically connected chamber and a membrane. In the event of a given deflection of the membrane into the first chamber, a first fluid is passed at least partly out of the first chamber into the second chamber in such a way that a second fluid is at least partly displaced from the second chamber into the third chamber in such a way that the third chamber is entirely filled with the second fluid.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: February 18, 2020
    Assignee: Robert Bosch GmbH
    Inventors: Thomas Brettschneider, Christian Dorrer
  • Patent number: 10564062
    Abstract: This disclosure relates generally to valves, and more particularly, to gas valve assemblies. In one example, a valve leakage test and/or other tests may be performed on a valve assembly including a valve body with a first valve and a second valve, where the valves may be positioned across a fluid path in the valve body with an intermediate volume between the valves. A human machine interface (HMI) may be in communication with the valve assembly to initiate and/or monitor tests on the valve assembly. The HMI may include a start button on a user interface for initiating the tests on valve assembly. The HMI may receive results of the tests (e.g., valve leakage tests) in real time during the test and display the results of the tests on a display of the HMI in real time.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: February 18, 2020
    Assignee: Honeywell International Inc.
    Inventors: Karen Karg, Donald J. Kasprzyk, Pallavi Dharwada
  • Patent number: 10557834
    Abstract: A sampling system comprising an external sampling assembly in fluidic communication with a process sample manager is provided herein. The sampling system can automatically acquire sample from one or more sources of sample to prepare sample for injection into a column or detector. The external sampling assembly has an external sampling valve connected to an external pump and is in fluidic communication with a process sample manager. The external sampling valve has a first configuration and a second configuration useful in three steps of drawing, loading and discharging sample. Two selection valves can be connected to a plurality of external sampling valves for sequential sampling of multiple sources of sample. Sample can also be diluted in the process sample manager and then combined in a solvent composition stream for injection into the column or the detector.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: February 11, 2020
    Assignee: WATERS TECHNOLOGIES CORPORATION
    Inventor: Sylvain Cormier
  • Patent number: 10551360
    Abstract: A low dead-volume connector for fluid chromatography, such as liquid chromatography and gas chromatography, has a female assembly including a receiving member being designed and configured to receive, and releasably interlock with, a male assembly. The connector is particularly suited for high performance liquid chromatography (HPLC) applications.
    Type: Grant
    Filed: October 11, 2016
    Date of Patent: February 4, 2020
    Inventors: Peter A. Nielsen, Nicolai Bache, Christoph Gebhardt, Ralph Kikillus
  • Patent number: 10485760
    Abstract: Disclosed herein are a method for producing a miniaturized liposome on a large production scale, and an apparatus for producing a liposome which is to be used in the above-mentioned method. Provided is a method for producing a liposome, including a step of stirring a mixture containing an oil phase in which at least one lipid is dissolved in an organic solvent and a water phase in a first tank of an apparatus having the first tank and a circulation path, in which the ratio of the capacity of the circulation path to the total capacity of the tank and the circulation path is 0.4 or less and/or the time required for the mixture to return to the first tank after being discharged therefrom is within 2.0 minutes.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: November 26, 2019
    Assignee: FUJIFILM Corporation
    Inventors: Susumu Sugiyama, Naoki Yamada, Shigehisa Sugiyama, Yohei Okubo
  • Patent number: 10488375
    Abstract: A sample cartridge for a liquid chromatography device includes a microfluidic chip. A collector in the microfluidic chip includes a collector flow channel and a first window for acquisition of spectral data from a sample in the collector flow channel.
    Type: Grant
    Filed: May 31, 2018
    Date of Patent: November 26, 2019
    Assignee: Venica Fluid Sciences Limited
    Inventors: Gregory W. Auner, Michelle A. Brusatori, Ronald F. Johnson
  • Patent number: 10471161
    Abstract: A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group.
    Type: Grant
    Filed: March 8, 2014
    Date of Patent: November 12, 2019
    Assignees: University of Southern California, City of Hope
    Inventors: Zibo Li, Peter S. Conti, Lin Li, Zhanhong Wu, Shuanlong Liu, John E. Shively, David Horne
  • Patent number: 10472309
    Abstract: The present invention provides a composition comprising an HFO compound, the composition having excellent stability with decomposition and oxidation of the HFO compound being inhibited, the composition having improved refrigerating capacity when used as a heat transfer medium, compared with the case in which an HFO compound is used alone. More specifically, the present invention provides a composition comprising at least one HFO compound selected from the group consisting of HFO-1234yf, (E-/Z-)HFO-1234ze, and (E-/Z-)HFO-1225ye; and a chlorine-containing compound, wherein (1) the chlorine-containing compound is at least one member selected from the group consisting of CH2?CHCl, CHF?CHCl, CH2?CFCl, CF3Cl, CH3Cl, CF3CH2Cl, CClF?CHCl, and CHF?CCl2, and (2) the chlorine-containing compound is contained in an amount ranging from 1 to 500000 mass ppm.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: November 12, 2019
    Assignee: DAIKIN INDUSTRIES, LTD.
    Inventors: Takehiro Chaki, Daisuke Karube
  • Patent number: 10450456
    Abstract: Polyoxymethylene compositions, articles comprising these compositions, and processes of making the compositions, comprising: a) at least one polyoxymethylene polymer; b) about 0.1 to about 5 wt. % of poly alpha-1,3-glucan having a d90 particle size of 50 microns or less; c) optionally, at least one additive selected from the group consisting of nucleating agents, waxes, ultraviolet stabilizers, colorants, antioxidants, formaldehyde scavengers, lubricants, and mixtures of these; wherein an article molded from said polyoxymethylene composition exhibits a formaldehyde emission of 1 weight percent or less when measured according to TEF test method.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: October 22, 2019
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventor: Ramabhadra Ratnagiri
  • Patent number: 10429359
    Abstract: Automated two step chromatography purification system comprising a, system controller, a capture flow path comprising at least one pump, an elution flow path comprising at least one pump, and a valve arrangement for selective connection of two capture columns to the capture flow path and the elution flow path respectively such that both flow paths may be operated simultaneously and in parallel.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: October 1, 2019
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Christer Olof Eriksson, Nils Norrman
  • Patent number: 10429362
    Abstract: Disclosed herein is a system for desorbing and detecting an analyte sorbed on a solid phase microextraction (SPME) device. The system includes a desorption chamber sized to accept the SPME device while defining a void volume of less than about 50 ?L; a flow injector in fluid connection with the desorption chamber, the desorption chamber and the flow injector being fluidly connected by at least a flow-insulating fluid connector; a solvent source in fluid connection with the flow injector; and a fluid switch that: in a desorption position, allows the solvent to be sprayed from the flow injector while flow-insulating any desorption solution in the desorption chamber, and in an detecting position, turns off the solvent source while maintaining the fluid connection between the flow injector and the desorption chamber, transferring the desorption solution through the flow-insulating fluid connector to the flow injector as a substantially undiluted plug of liquid.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: October 1, 2019
    Assignee: JP SCIENTIFIC LIMITED
    Inventor: Janusz B. Pawliszyn
  • Patent number: 10429364
    Abstract: A method for analyzing a sample can include obtaining an exclusion list of retention time and mass-to-charge ranges corresponding to high abundance compounds within a sample; separating components of the sample using the chromatographic column; obtaining a first mass data set using the mass analyzer while excluding ions within retention time and mass-to-charge ranges of the exclusion list; generating an inclusion list of features of the first mass data set; fragmenting ions corresponding to features of the inclusion list; obtaining a second mass data set from the fragmented ions; and identifying and/or quantifying low abundance compounds based on the second mass data set.
    Type: Grant
    Filed: January 31, 2017
    Date of Patent: October 1, 2019
    Assignee: THERMO FINNIGAN LLC
    Inventors: Iman Mohtashemi, Timothy Stratton, Michael A. Blank
  • Patent number: 10422452
    Abstract: Fluidic connection assemblies, ports, unions and other components are provided that are well-suited for use in HPLC and UHPLC, as well as in other analytical instrument systems. Such assemblies, ports, unions and components can be biocompatible.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: September 24, 2019
    Assignee: IDEX Health & Sciences LLC
    Inventors: Craig Graham, Don Pein
  • Patent number: 10422777
    Abstract: A clamp for chromatography columns has a first seal with a first opening a movable seal with a second opening and a movable coupler. The movable coupler has first and second coupler seals with communicating third and fourth openings. The clamp is arranged for pressing a first chromatography column between the first seal and the first coupler seal and for pressing a second chromatography column between the movable seal and the second coupler seal, such that the first opening fluidly communicates with the second opening through the first chromatography column, the third and fourth openings and the second chromatography column.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: September 24, 2019
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventor: David Lerner
  • Patent number: 10422776
    Abstract: A method of preparing a liquid mixture for use in a liquid chromatography system is provided. The mixture comprises one or more acids, one or more bases, one or more solvents and water, and the method comprises the steps of: calculating pH and/or solvent concentration at a particular time t from a user-determined gradient function; and, based on the values obtained, calculating percent acid, percent base, percent solvent and percent water in the liquid mixture at time t. A liquid chromatography system incorporating such method is also provided.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: September 24, 2019
    Assignee: Waters Technologies Corporation
    Inventors: Thomas E. Wheat, Patricia McConville, John R. Lamoureux, Aparna Chavali
  • Patent number: 10408800
    Abstract: The present invention relates to a real-time automatic analysis device for an organic contaminant in water, the device having: an analysis apparatus comprising a solid phase micro-extraction device and a gas chromatography/mass spectrometry analysis device that have been traditionally used; a heating block; a sample bottle; a discharge unit; and a control unit. While using an analysis apparatus, being traditionally used, as it is, the real-time automatic analysis device for an organic contaminant in water accurately and quickly identifies a point of generation of a high-concentration organic contaminant by supplying a sample consecutively and in real time, takes follow-up measures, and easily performs a sensory analysis as well as a chemical analysis.
    Type: Grant
    Filed: September 23, 2015
    Date of Patent: September 10, 2019
    Assignee: REPUBLIC OF KOREA (MINISTRY OFENVIRONMENT, NATIONAL INSTITUTE OF ENVIRONMENTAL RESEARCH)
    Inventors: In-Cheol Choi, Hyen-Mi Chung, Ju-Hyun Park, Oh-Sang Kwon, Yu-Jeong Huh, Kyung-Hee An
  • Patent number: 10408716
    Abstract: One or more homogenizing elements are employed in a flow through, multi-detector optical measurement system. The homogenizing elements correct for problems common to multi-detector flow-through systems such as peak tailing and non-uniform sample profile within the measurement cell. The homogenizing elements include coiled inlet tubing, a flow distributor near the inlet of the cell, and a flow distributor at the outlet of the cell. This homogenization of the sample mimics plug flow within the measurement cell and enables each detector to view the same sample composition in each individual corresponding viewed sample volume. This system is particularly beneficial when performing multiangle light scattering (MALS) measurements of narrow chromatographic peaks such as those produced by ultra-high pressure liquid chromatography (UHPLC).
    Type: Grant
    Filed: September 21, 2016
    Date of Patent: September 10, 2019
    Assignee: WYATT TECHNOLOGY CORPORATION
    Inventors: Philip J. Wyatt, Vincent H. Hsieh, Mario Yasa, Barbara R. Maurer, David Cannell, Steven P. Trainoff
  • Patent number: 10393636
    Abstract: Disclosed herein is a system for desorbing and detecting an analyte sorbed on a solid phase microextraction (SPME) device. This SPME device The system includes a desorption chamber containing solvent required for desorption of analytes from SPME device; a flow injector in fluid connection with the desorption chamber, the desorption chamber and the flow injector being fluidly connected by at least a flow-insulating fluid connector; a solvent source in fluid connection with the flow injector; and a fluid switch that: in a desorption position, allows the solvent to be sprayed from the flow injector while flow-insulating any desorption solution in the desorption chamber, and in an detecting position, turns off the solvent source while maintaining the fluid connection between the flow injector and the desorption chamber, transferring the desorption solution through the flow-insulating fluid connector to the flow injector as a substantially undiluted plug of liquid.
    Type: Grant
    Filed: June 7, 2018
    Date of Patent: August 27, 2019
    Inventors: Janusz Pawliszyn, Marcos Tascon, Varoon Singh
  • Patent number: 10393710
    Abstract: A system and method are disclosed for analyzing samples, which includes a spectrometry system for detecting components of a sample; a gas chromatography column for separating the components of a sample; a first sample unit for receiving a first sample from a sample source; and a second sample unit for receiving a second sample from a sample source. Each sample loop unit allows independent processing of samples in preparation for analysis.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: August 27, 2019
    Assignee: MLS ACQ, INC.
    Inventors: Martin L. Spartz, Anthony S. Bonanno, Peter P. Behnke
  • Patent number: 10391423
    Abstract: A lattice and distribution network for a stackable chromatography cassette comprising: a peripheral seal; at least one screen forming the lattice surrounded by the peripheral seal, each at least one screen comprising a plurality of struts in a latticed arrangement; a first internal distribution network fluidly coupled to the lattice and surrounded by the peripheral seal; a second internal distribution network disposed opposite the first internal distribution network, fluidly coupled to the lattice and surrounded by the peripheral seal; wherein a direction of fluid flow is established from the first internal distribution network through the lattice to the second internal distribution network; and wherein preferential streamlines are minimized.
    Type: Grant
    Filed: March 11, 2017
    Date of Patent: August 27, 2019
    Assignee: SPF TECHNOLOGIES LLC
    Inventor: Gaston de los Reyes