Hemodialysis Patents (Class 210/646)
  • Patent number: 11027052
    Abstract: Methods of priming a plasma processing system are disclosed. The plasma processing system has a number of different fluid flow circuits that are defined by sources of fluid, fluid flow paths, waste containers, a mixer, a separator, valves and a pump. A first fluid circuit is flushed, where the first fluid circuit is defined by a source of a first fluid, a first valve positioned between the source of the first fluid and the first fluid flow path, a second valve positioned between the first fluid flow path and the second fluid flow path, a first pump positioned between the second fluid flow path and the third fluid flow path, and a first waste container in fluid communication with the third fluid flow path. A second fluid circuit is then flushed by closing and opening certain valves.
    Type: Grant
    Filed: November 21, 2018
    Date of Patent: June 8, 2021
    Assignee: HDL Therapuetics, Inc.
    Inventors: Hollis Bryan Brewer, Michael M. Matin, Timothy Jon Perlman
  • Patent number: 10994065
    Abstract: The invention relates to an apparatus for carrying out an extracorporeal blood treatment in which a substitution fluid is administered to the patient, wherein the apparatus comprises an extracorporeal blood circuit and a substitution line opening into the extracorporeal blood circuit, wherein the substitution line has a pump for conveying substitution fluid into the extracorporeal circuit, wherein at least two, and preferably more than two, containers for the provision of a substitution fluid are connected separately and at the intake side of the pump to the substitution line, and wherein at least one pressure valve is arranged between the pump and at least one of the containers, said pressure valve allowing a flow of substitution fluid to the pump on an exceeding of an opening pressure.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: May 4, 2021
    Assignee: FRESNIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Lars Breuel, Juergen Klewinghaus
  • Patent number: 10993961
    Abstract: The present invention concerns a dialysis acid precursor composition for use during preparation of a dialysis acid concentrate solution and for mixing with water and a bicarbonate containing concentrate into a ready-for-use dialysis solution. Said dialysis acid precursor composition consist of powder components comprising sodium chloride, at least one dry acid and at least one magnesium salt, and optionally potassium salt, calcium salt, and glucose. According to the invention said at least one magnesium salt and said optional glucose, are present as anhydrous components in said dialysis acid precursor composition.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: May 4, 2021
    Assignee: Gambro Lundia AB
    Inventors: Ola Carlsson, Torbjorn Linden, Lennart Jonsson, Anders Wieslander
  • Patent number: 10973968
    Abstract: A home medical device system includes a home therapy machine for performing a home therapy on a patient; a user interface operably connected to the home therapy machine, the user interface receiving operator inputs; a water treatment device in fluid communication with the home therapy machine; and a data connection between the home therapy machine and the water treatment device, wherein the home therapy machine transmits data via the connection to the water treatment device for control of the water treatment device, the data provided based on at least one of the operator inputs received via the user interface.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: April 13, 2021
    Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE S.A.
    Inventor: Justin B. Rohde
  • Patent number: 10962252
    Abstract: Systems and methods are disclosed herein for a three-fluid liquid-to-air membrane energy exchanger (LAMEE) to condition air (a first overall fluid). A liquid panel assembly used in the LAMEE can include a first fluid circuit for a first cooling fluid (a second overall fluid) and a second fluid circuit for a second cooling fluid (a third overall fluid). The first cooling fluid, also referred to herein as a desiccant, can be configured to circulate through the liquid panel assembly and condition an air stream passing through the LAMEE. The second cooling fluid, also referred to herein as a coolant, can be configured to also circulate through the panel assembly and reject heat from the first cooling fluid. The second cooling fluid can increase the cooling capacity and overall performance of the LAMEE. The first and second cooling fluids can be separate from each other during circulation through the panel assembly.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: March 30, 2021
    Assignee: Nortek Air Solutions Canada, Inc.
    Inventors: Philip Paul LePoudre, Davood Ghadiri Moghaddam, Manfred Gerber
  • Patent number: 10946134
    Abstract: According to some embodiments, a system may treat blood outside the body of a patient. The system may include at least one toxin removal system configured to process blood from at least two places on the patient's body at a rate, for example, of at least 0.5 liters per minute. The system may be configured to raise the pH level of the patient's blood by introducing a fluid at rate of at least 9 liters per hour.
    Type: Grant
    Filed: February 6, 2017
    Date of Patent: March 16, 2021
    Assignee: Humanity Life Extension LLC
    Inventor: Patrick Richard Spearman
  • Patent number: 10926014
    Abstract: The present invention relates to a cassette module for controlling fluid flows, in particular for use in blood treatment systems or in infusion systems, wherein the cassette module comprises at least one base body having means for the flow guidance of at least one fluid flow and at least two membranes which are at least sectionally directly or indirectly in contact with the base body, wherein at least one actuation element is arranged between the membranes by means of which the means for the flow guidance can be acted on.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: February 23, 2021
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Stefan Kreber, Manfred Weis, Marina Wenke, Lothar Leick
  • Patent number: 10926015
    Abstract: The present invention relates to a cassette module for controlling fluid flows, in particular for use in blood treatment systems or in infusion systems, wherein the cassette module has at least one first functional layer and at least one second functional layer, wherein the first functional layer has means for the flow guidance of at least one fluid flow, and wherein the cassette module furthermore has at least two membranes of which the first is in contact with the means for the flow guidance of a fluid flow, and wherein the second functional layer is arranged between the two membranes and has means for generating an underpressure between the membranes.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: February 23, 2021
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Stefan Kreber, Manfred Weis, Marina Wenke
  • Patent number: 10918778
    Abstract: A Direct Sodium Removal method, apparatus and solution for treating patients in heart failure, and having a glomerular filtration rate greater than 15 mL/min/1.73 m2, or residual kidney function corresponding to normal to CKD Stage 4, is provided in which a no or low sodium DSR infusate is administered to the peritoneal cavity for a predetermined dwell period and then removed, thereby removing sodium from the body. The resulting elimination of fluid from the patient by i) functioning of the kidneys through urination and ii) direct removal of osmotic ultrafiltrate from the peritoneal cavity, restores serum sodium concentrations to healthy levels and thereby reduces fluid overload in the patient.
    Type: Grant
    Filed: May 21, 2018
    Date of Patent: February 16, 2021
    Assignee: Sequana Medical NV
    Inventors: Neil Inhaber, Noel Johnson, Dirk Fengels, Ian Crosbie
  • Patent number: 10881776
    Abstract: The invention relates to a control unit (30) for detecting an overshoot of a first limit value (G1) of a first blood concentration (B1) in a first portion (17a) of a dialysate discharge line (17) downstream of a dialysate chamber (7) of a dialyser (4) of a blood treatment device and upstream of a node point (110) at which a bypass line (100) bypassing the dialyser (4) leads into the dialysate discharge line (17), wherein the bypass line (100) branches off, upstream of the dialysate chamber (7), from a dialysate supply line (15) suitable for supplying dialysate from a dialysate source (16) to the dialysate chamber (7).
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: January 5, 2021
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventor: Alfred Gagel
  • Patent number: 10857278
    Abstract: A method of identifying a type of a filter, which has at least one retentate side and at least one permeate side separated from one another by at least one filter medium, includes generating a pressure in a fluid, in particular in a liquid, on the retentate side or on the permeate side via a pressure source. The method then includes switching off the pressure source, and measuring a pressure development in the fluid over time subsequent to the switching off of the pressure source.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: December 8, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Martin Thys, Joachim Noack
  • Patent number: 10835659
    Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: November 17, 2020
    Assignee: NxStage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Dennis M. Treu, Daniel J. Rubery, Jr., Scott W. Newell, James M. Brugger, William J. Schnell, William K. Weigel, Steven A. White, Mark T. Wyeth, Jerome James, David Desouza, Joseph E. Turk, Jr., Garrett Casey
  • Patent number: 10792412
    Abstract: A method for venting a dialyzer which has a dialyzate chamber, a blood chamber and a semi-permeable dialyzer membrane separating these two chambers. An overpressure is generated in the dialyzate chamber with respect to the blood chamber for removing air inclusions lying at the surface of the membrane at the dialyzate chamber side after a filling of the dialyzate chamber and before a filling of the blood chamber.
    Type: Grant
    Filed: July 27, 2016
    Date of Patent: October 6, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Peter Kloeffel, Thomas Nuernberger
  • Patent number: 10773263
    Abstract: A system is provided that includes a controller in a control cabinet, a touch screen having a plurality of control icons, a controlled device, and a single safety sensor. The controlled device is a continuous flow centrifugation system. The controller prevents operation of the controlled device without simultaneous contact by a user of both the single safety sensor and a respective one of the plurality of control icons.
    Type: Grant
    Filed: August 2, 2016
    Date of Patent: September 15, 2020
    Assignee: ALFA WASSERMANN, INC.
    Inventors: Kurt Spiegel, Sorin Weissman, Bill Lepse, Blaine J. Marsh
  • Patent number: 10758661
    Abstract: An extracorporeal blood processing system comprises a plastic molded compact manifold that supports a plurality of molded blood and dialysate fluidic pathways along with a plurality of relevant sensors, valves and pumps. A disposable dialyzer is connected to the molded manifold to complete the blood circuit of the system. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: September 1, 2020
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Thomas Patrick Robinson, Charles E. Clemens, David Jacob Mishelevich, James Roswell Braig, Barry Neil Fulkerson, Daniele Ghidoli, Russell Thomas Joseph
  • Patent number: 10744258
    Abstract: A whole blood treatment device includes a first conduit, a second conduit, and a rotating or reciprocating element having a channel. The first and second conduits are fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the second conduit, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the second conduit. The first conduit is configured to receive whole blood, and the second conduit is configured to receive a regeneration fluid. The channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: August 18, 2020
    Assignee: Qualigen Inc.
    Inventor: Michael Poirier
  • Patent number: 10702620
    Abstract: The present application relates to a method for disinfection of a temperature control device for human body temperature control during extracorporeal circulation which temperature control is conducted by use of a heat exchanger and a temperature control liquid circulating through the heat exchanger and the temperature control device. According to the present application, the temperature control device is connected to a temperature control liquid supply and, during operation of the temperature control device for human body temperature control, a disinfectant is selectively added to the temperature control liquid supply upstream of the temperature control device.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: July 7, 2020
    Assignee: LivaNova Deutschland GmbH
    Inventors: Johann Schreyer, Erwin Knott, Olivier Wolfgramm
  • Patent number: 10704021
    Abstract: Acoustic perfusion devices and processes for separating biomolecules from other material in a fluid mixture are disclosed. The devices include an inlet port, an outlet port, and a collection port that are connected to an acoustic chamber. An ultrasonic transducer creates an acoustic standing wave in the acoustic chamber that permits a continuous flow of fluid to be recovered through the collection port while keeping the biological cells within the acoustic chamber to be returned to the bioreactor from which the fluid mixture is being drawn.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: July 7, 2020
    Assignee: FloDesign Sonics, Inc.
    Inventors: Bart Lipkens, Benjamin Ross-Johnsrud, Erik Miller, Mark Brower
  • Patent number: 10695478
    Abstract: A method of supplying treatment parameters for a dialysis treatment includes supplying a predetermined machine-related data record of machine-related treatment parameters that are stipulated independently of the treatment of a specific patient, supplying a patient-related data record from patient-related treatment parameters of a patient to be treated, independently of a dialysis machine or a type of device provided for the treatment, selecting a machine-related data record for a specified dialysis treatment, and using the machine-related data record and the patient-related data record to generate a treatment data record for defining treatment parameters of the dialysis treatment to be performed.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: June 30, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Peter Eifler, Marco Graefe, Helmut Steil
  • Patent number: 10661003
    Abstract: The invention provides an apparatus of treating water to obtain small water cluster, which comprises one or more illumination devices and one or more holders holding metal particles. The invention also provides a method of preparing the small water cluster and the small water cluster prepared from the apparatus or the method.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: May 26, 2020
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventor: Yu-Chuan Liu
  • Patent number: 10653826
    Abstract: Dialysis systems that remove air from a blood circuit are disclosed herein. In an embodiment, a dialysis system includes a dialysis fluid circuit, a blood circuit including an arterial line, a venous line, and an enclosure in fluid communication with the venous line, the enclosure configured to release air through a hydrophobic vent for priming the blood circuit, a blood pump configured to pump fluid through at least the arterial line, a first valve operable with the arterial line and a second valve operable with the venous line, and a pumping and valving algorithm operated after priming to remove air from the blood circuit to control the first and second valves and the blood pump to replace priming fluid with blood from a patient.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: May 19, 2020
    Assignees: Baxter International Inc., Bazter Healthcare SA
    Inventors: Thomas D. Kelly, Marc S. Minkus, Angelito A. Bernardo, William P. Burns, Robert W. Childers, Shincy J. Maliekkal, Matthew R. Muller, Justin B. Rohde, Michael E. Hogard
  • Patent number: 10632243
    Abstract: A dialysis system includes at least one source of fluid for dialysis, a fluid line in fluid communication with the at least one source of fluid, at least one pump positioned and arranged to pump fluid from the at least one source of fluid through the fluid line, a first patient connector configured to be removably placed in fluid communication with the fluid line to allow a blood treatment to be performed using the at least one source of fluid, and a second patient connector configured to be removably placed in fluid communication with the fluid line to allow a peritoneal dialysis treatment to be performed using the at least one source of fluid.
    Type: Grant
    Filed: September 8, 2016
    Date of Patent: April 28, 2020
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Justin Belanger Rohde, Marc Steven Minkus
  • Patent number: 10625007
    Abstract: A blood purification apparatus and a blood purification system that is operable with increased ease even if a blood purifier requires special treatment conditions and operational settings is used. A blood purification apparatus includes a blood purifier for giving blood purification treatment by purifying blood of a patient; and a control device that executes, in accordance with preset treatment conditions and/or operational settings, an operation for performing the blood purification treatment or an operation associated with the blood purification treatment.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: April 21, 2020
    Assignee: Nikkiso Company Limited
    Inventors: Kentaro Kogoshi, Masahiro Aoshima, Satoshi Takeuchi
  • Patent number: 10610634
    Abstract: A blood purification apparatus includes a blood circuit through which blood of a patient extracorporeally circulate, and a dialyzer that purifies the blood flowing in the blood circuit.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: April 7, 2020
    Assignee: Nikkiso Company Limited
    Inventors: Shinya Hasegawa, Kunihiko Akita, Masahiro Toyoda
  • Patent number: 10583244
    Abstract: Embodiments of the current disclosure are directed toward systems, devices and methods for diabetes management. In particular, the present disclosure relates to devices and methods for dispensing insulin to a patient. A portable fluid infusion device, comprising a disposable part (DP) and a reusable part (RP) is disclosed. The DP comprises a first reservoir and a second reservoir, the second reservoir less than or equal to the first reservoir in length, while the RP comprises a first compartment configured to receive the first reservoir, a second compartment configured to receive the second reservoir and a gasket for sealing a junction between the second reservoir and the second compartment upon connection of the RP and the DP.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: March 10, 2020
    Assignee: TRIPLE JUMP ISRAEL LTD.
    Inventors: Ofer Yodfat, Guy Shinar, Yishai Ben-David
  • Patent number: 10569000
    Abstract: A method includes: receiving measurements of a blood-related parameter corresponding to a patient undergoing hemodialysis; estimating a value of one or more hemodialysis treatment-related parameters by applying a vascular refill model based on the received measurements of the blood-related parameter, wherein the one or more hemodialysis treatment-related parameters are indicative of an effect of vascular refill on the patient caused by the hemodialysis; determining, based on the one or more estimated values of the one or more hemodialysis treatment-related parameters, a hemodialysis treatment-related operation; and facilitating performance of the treatment-related operation. The vascular refill model is a two-compartment model based on a first compartment corresponding to blood plasma in the patient's body, a second compartment based on interstitial fluid in the patient's body, and a semi-permeable membrane separating the first compartment and the second compartment.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: February 25, 2020
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Aurelio A. De los Reyes, V, Doris H. Fuertinger, Franz Kappel, Anna Meyring-Wosten, Stephan Thijssen, Peter Kotanko
  • Patent number: 10532147
    Abstract: The invention relates to a method of flushing an extracorporeal blood circuit, preferably an extracorporeal blood circuit of a dialysis machine, with a flushing liquid, wherein the flushing liquid contains an anticoagulant agent, preferably heparin. The invention further relates to an extracorporeal blood treatment unit, preferably to a dialysis machine, having an extracorporeal blood circuit and a control unit, wherein the control unit is configured to carry out a flushing method in accordance with one of the preceding claims before the start of the treatment and/or intermittently during the treatment.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: January 14, 2020
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Ralf Wojke, Paul Wieneke
  • Patent number: 10525182
    Abstract: The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: January 7, 2020
    Assignee: NxStage Medical, Inc.
    Inventors: Jeffrey H. Burbank, Dennis M. Treu, Daniel J. Rubery, Jr., Scott W. Newell, James M. Brugger, William J. Schnell, William K. Weigel, Steve A. White, Mark T. Wyeth, Jerome James, David Desouza, Joseph E. Turk, Jr., Garrett Casey
  • Patent number: 10507279
    Abstract: A control system (23) is arranged to control the operation of an apparatus (200) for extracorporeal blood treatment. The apparatus (200) comprises an extracorporeal blood circuit (20) and a connection system (C) for connecting the blood circuit (20) to the vascular system of a patient. The blood circuit (20) comprises a blood processing device (6), and at least one pumping device (3). The control system is operable to switch between a pre-treatment mode and a blood treatment mode. The blood treatment mode involves operating the blood circuit (20) to pump blood from the vascular system via the connection system (C) through the blood processing device (6) and back to the vascular system via the connection system (C). The control system (23) is operable to obtain measurement data from at least one energy transfer sensor (40) arranged to sense a transfer of energy between the patient and the connection system (C) or between the patient and the blood circuit (20).
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: December 17, 2019
    Assignee: Gambro Lundia AB
    Inventors: Bo Olde, Kristian Solem, Thomas Hertz, Jan Sternby, Anders Wieslander
  • Patent number: 10500327
    Abstract: A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.
    Type: Grant
    Filed: June 1, 2018
    Date of Patent: December 10, 2019
    Assignee: DEKA Products Limited Partnership
    Inventors: Kevin L. Grant, James D. Dale, Michael J. Wilt, Jason A. Demers, David E. Collins, Brian D. Tracey
  • Patent number: 10493406
    Abstract: A filter module (1) has a housing (2) formed from a plastic and a filter (3) made from a plastic is arranged in the housing (2). The housing (2) is bonded adhesively to the filter (3) by an adhesive (15) via a first bonding surface (7, 18) made from a first plastic and via a second bonding surface (14, 19, 21) made from a second plastic. The adhesive bonding of the first bonding surface (7, 18) and the second bonding surface (14, 19, 21) is accomplished via an intermediate piece (10, 20) with the bonding surfaces (14, 18, 21) made from a plastic that is identical to or different from the first plastic. At least one of the bonding surfaces (7, 18, 19, 14, 21) has been activated by plasma or corona pre-treatment prior to the adhesive bonding.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: December 3, 2019
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Ralf Lausch, Paschalis Nikoloudis, Wilhelm Requate, Johannes Wortmeyer
  • Patent number: 10471208
    Abstract: Methods, systems, and apparatuses for integrating medical device data are disclosed. In an example embodiment, an integration engine includes a configuration interface configured to receive a patient identifier. The integration engine also includes a subscription processor configured to transmit a first message, including the patient identifier, to a first gateway to receive infusion therapy progress data from at least one infusion pump and transmit a second message, including the patient identifier, to a second gateway to receive renal failure therapy progress data from at least one renal failure therapy machine. The integration engine further includes a data processor configured to receive the infusion therapy progress data from the first gateway, receive the renal failure therapy progress data from the second gateway, and cause a combination user interface to display the infusion therapy progress data and the renal failure therapy progress data.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: November 12, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventor: Jonathan Alan Handler
  • Patent number: 10471195
    Abstract: In general, a dialysis device includes a first processing device for monitoring dialysis functions of the dialysis device, a second processing device, a display device, and memory. The memory is configured to store instructions that, when executed, cause the dialysis device to provide, on the display device, a first display region and a second display region, where the first display region is associated with the first processing device and the second display region is associated with the second processing device. At least a portion of the first display region cannot be obscured by the second display region.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: November 12, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Fei Wang, Martin Joseph Crnkovich, Roland Levin, Michael Emmanuel Kotsos
  • Patent number: 10441702
    Abstract: Devices, systems, and methods can be used to deliver temperature-controlled medical fluids to patients. For example, this disclosure provides devices, systems, and methods for controlling the temperature of dialysate delivered to a patient during a peritoneal dialysis treatment.
    Type: Grant
    Filed: October 4, 2016
    Date of Patent: October 15, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: William Scott Crawford, Robert Matthew Ohline
  • Patent number: 10420797
    Abstract: The present invention concerns an anticoagulation fluid comprising 10-40 mM citrate and 0.1-4 mM phosphate. The anticoagulation fluid is to be used for regional citrate anticoagulation in an extracorporeal blood circuit. The anticoagulation fluid may be combined with at least one treatment fluid in the dialysis treatment, and it may be included in a system for regional citrate anticoagulation in an extracorporeal blood circuit.
    Type: Grant
    Filed: April 30, 2014
    Date of Patent: September 24, 2019
    Assignee: Gambro Lundia AB
    Inventors: Jan Sternby, Anders Wieslander
  • Patent number: 10413237
    Abstract: The present invention relates to a method for calculating or approximating a value representing the relative blood volume (RBV) at a certain point of time, or a value representing the refilling volume of a patient that may be observed or found during or due to a blood treatment of the patient, the method involving considering one or more calculated or measured value(s) reflecting an overhydration level of the patient or an approximation thereof. It relates further to an apparatus and a device for carrying out the present invention, a blood treatment device, digital storage means, a computer program product, and a computer program.
    Type: Grant
    Filed: December 21, 2011
    Date of Patent: September 17, 2019
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Ulrich Moissl, Paul Chamney, Volker Nier, Peter Wabel, Sebastian Wieskotten
  • Patent number: 10406272
    Abstract: A method for determining or approximating a patient's daily loss of iron (fe_loss), the method comprising the steps of determining the patient's iron uptake (fe_uptake); determining the quantity of iron stored within the patient's body; and determining the patient's daily loss of iron based on the patient's iron uptake (fe_uptake) and the quantity of non-functional iron stored within the patient's body. The method relates further to apparatuses and an erythropoesis stimulating medicament for use in the treatment of anaemia. Finally the present invention relates to digital storage means, a computer program product, and a computer program.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: September 10, 2019
    Assignee: Fresenius Medical Care Deutschland GmbH
    Inventors: Ulrich Moissl, Volker Nier, Paul Chamney, Peter Wabel
  • Patent number: 10398827
    Abstract: An extracorporeal blood treatment apparatus (1) comprising a control unit (10) connectable to a blood warming device (200). The apparatus (1) comprises: an extracorporeal blood circuit (100) and at least one infusion line (15, 21, 25) connected to the extracorporeal blood circuit (100). A control unit (10) is configured to execute the following procedure: receiving a first value representative of a desired blood temperature (Tdes) at an end (70) of a blood return line (7) configured to be connected to a venous vascular access of a patient (P); receiving at least a first signal relating to at least a flow rate (QPBP, QREP1, QREP2) of an infusion fluid in the at least one infusion line (15, 21, 25); calculating a set point value of an operating parameter (TOUT; Pw) to be imposed on the warming device (200) configured to heat a blood heating zone (H) of the extracorporeal blood circuit (100) in order to maintain the desired blood temperature (Tdes) at the end (70) of the blood return line (7).
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: September 3, 2019
    Assignee: Gambro Lundia AB
    Inventor: Dominique Pouchoulin
  • Patent number: 10391220
    Abstract: A system includes a dialyzer having a blood side and a dialysate side, a first extracorporeal circuit including one or more first fluid connectors for connecting the blood side of the dialyzer to the vascular system of a kidney patient, a second extracorporeal circuit including one or more second fluid connectors for connecting the dialysate side of the dialyzer to the vascular system of a healthy animal, a first pump in fluid communication with at least one of the first and second extracorporeal circuits, and a driver mechanically coupled to the first pump, where the driver is configured to drive the first pump using energy from an energy source.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: August 27, 2019
    Assignee: FRESNIUS MEDICAL CARE HOLDINGS, INC.
    Inventors: Peter Kotanko, Stephan Thijssen
  • Patent number: 10376843
    Abstract: A leak may be detected in a heat exchanger of a hemodialysis device. A drain valve is opened by the controller, and then closed by the controller after a pre-selected time period. An initial pressure is determined in the spent dialysate circuit and stored in the memory. A system pressure is determined at periodic time intervals and compared to a pre-determined maximum pressure. The controller then determines whether the heat exchanger has a leak, in that in response to the system pressure exceeding a predetermined maximum pressure, a command is generated to execute an event including suspending a disinfectant operation with a disinfecting agent, and in response to the initial pressure subtracted from the system pressure being greater than a predetermined minimum pressure differential, a command is generated to execute an event including suspending the cleanse operation with the disinfecting agent.
    Type: Grant
    Filed: January 20, 2017
    Date of Patent: August 13, 2019
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventors: Martin Crnkovich, Roland Levin, Christopher McCormick, Fei Wang, Aiyuan Wang
  • Patent number: 10369347
    Abstract: A screw connector includes a first connector with a first lumen and an outside thread, and a second connector with an elastically deformable nut and an inside thread. The outside thread has a first formation and the nut has a second formation, the second formation is a recess in the base of the nut, and the inside thread and the outside thread are configured for mutual connection. The nut is configured for deformation by the first formation in a first angle-of-rotation range without the first formation engaging in the recess, and the inside thread, the outside thread, the first formation, and the recess are configured for engaging the first formation when the inside and outside threads are connected in a second angle-of-rotation range. The screw connector has a half-open sterilization position in the second angle-of-rotation range. In another range, the screw connector may be tightened to be gas-tight and/or liquid-tight.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: August 6, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventor: Martin Lauer
  • Patent number: 10363408
    Abstract: A screw connector for medical hose systems is configured for catch engagement in a half-open sterilization position. The connector includes a first connecting element having a first lumen and an outside thread, and a second connecting element having a second lumen, and an elastically deformable union nut having an inside thread. The inside thread and the outside thread are configured to be screwed together, with the outside thread having a first formation and the inside thread a second formation, with deformation of the nut via the first formation in a predetermined first angle-of-rotation range without engaging the second formation. The inside thread and the outside thread, and the first formation and the second formation, are configured for catch engagement of the first formation in the second formation when the inside thread and the outside thread are screwed together in a predetermined second angle-of-rotation range to provide the half-open sterilization position.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: July 30, 2019
    Assignee: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Uwe Lapp, Lothar Leick, Ralf Mueller, Peter Urban
  • Patent number: 10300191
    Abstract: A blood purification apparatus comprising: a blood circuit including an arterial blood circuit and a venous blood circuit and that is capable of extracorporeally circulating blood of a patient from a distal end of the arterial blood circuit to a distal end of the venous blood circuit; a blood purification device provided between the arterial and the venous blood circuit of the blood circuit and that is capable of purifying the blood flowing in the blood circuit; a dialysate introduction line for introducing dialysate into the blood purification device and a dialysate drain line for discharging drain liquid from the blood purification device; a liquid delivery pump provided to the dialysate introduction line and that is capable of causing the dialysate in the dialysate introduction line to flow; a heating device that is capable of heating the dialysate to be introduced from the dialysate introduction line into the blood purification device; a temperature-detecting device that is capable of detecting a temperat
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: May 28, 2019
    Assignee: Nikkiso Company Limited
    Inventors: Hiroaki Mochizuki, Harutoshi Okabe, Sumiaki Matsuo
  • Patent number: 10269267
    Abstract: Disclosed is a cardiopulmonary resuscitation training apparatus. The cardiopulmonary resuscitation training apparatus comprises: a mannequin; a compression plate which is provided towards the chest area of the mannequin and generates a return force; and a display unit which displays the state of the mannequin and shows blood circulation movement in light-emitting lines, in accordance with the pressing of the compression plate. The display unit can be constituted in such a way that the blood circulation movement in the mannequin is displayed by means of LEDs, and the LED movement rate is varied or the LEDs emit light in different colours in accordance with the depth of pressing or the pressing rate of the compression plate. This gives the advantage that the user can implement cardiopulmonary resuscitation close to reality while being made aware of the compression depth and the compression rate.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: April 23, 2019
    Assignee: INNOSONIAN INC.
    Inventors: Mok Chung, Choung Ho Jung, Nam Hun Kim, Hwan Chul Kim
  • Patent number: 10258728
    Abstract: Systems and methods are provided for performing selective sorbent-based regeneration of dialysate. The systems and method provide for dialysate regeneration to be carried out intermittently throughout a dialysis session, decreasing the necessary amounts of sorbent materials and infusates to conduct dialysis. The system and methods allow for regeneration of dialysate as needed based on the concentration of waste species in the dialysate, allowing for effective treatment with a decreased need for sorbent materials.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: April 16, 2019
    Assignee: Medtronic, Inc.
    Inventor: Martin T. Gerber
  • Patent number: 10245370
    Abstract: A renal failure therapy machine includes a blood cleaning filter, a dialysis fluid circuit including a balance chamber, the balance chamber including a fresh dialysis fluid compartment configured to send fresh dialysis fluid to the blood cleaning filter and a used dialysis fluid compartment configured to receive used dialysis fluid from the blood cleaning filter, a fresh dialysis fluid line in fluid communication with the fresh dialysis fluid compartment of the balance chamber and the blood cleaning filter, and a flow restrictor in fluid communication with the blood cleaning filter, the flow restrictor configured to cause fresh dialysis fluid delivered from the fresh dialysis fluid compartment, through the fresh dialysis fluid line, to the blood cleaning filter to be pressurized so that a first amount of the fresh dialysis fluid performs convective clearance and a second amount of the fresh dialysis fluid performs diffusive clearance.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: April 2, 2019
    Assignees: Baxter International Inc., Baxter Healthcare SA
    Inventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
  • Patent number: 10238788
    Abstract: A portable irrigation system comprising a reservoir for an irrigating liquid, a probe for arrangement in a user, an electrical system, a control unit for controlling the transfer of irrigation liquid and tubing providing fluid communication between said reservoir, control unit and probe.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: March 26, 2019
    Assignee: DENTSPLY IH AB
    Inventor: Erik Andréen
  • Patent number: 10232101
    Abstract: A gas exchange system may include an elongate member including a liquid circuit and configured to be inserted into a body lumen, and a gas exchanger in fluid communication with the elongate member. A gas transfer fluid may be disposed within the liquid circuit of the elongate member. The gas transfer fluid may be configured to absorb carbon dioxide from a body fluid disposed in the body lumen, and subsequently release the carbon dioxide in the gas exchanger.
    Type: Grant
    Filed: February 11, 2016
    Date of Patent: March 19, 2019
    Assignee: Boston Scientific Scimed, Inc.
    Inventors: Aiden Flanagan, Bryan Allen Clark
  • Patent number: 10220131
    Abstract: The blood purification system includes a plurality of monitoring devices (1) with a dialyzer (5) to perform a blood purification treatment on a patient. A dialysate supplying device (2) supplies a dialysate to each of the monitoring devices (1). The plurality of monitoring devices (1) and the dialysate supplying device (2) are connected to each other by a LAN cable ?. Predetermined information can be transmitted from the dialysate supplying device (2) to a specified monitoring device (1), out of the plurality of monitoring devices (1). The specified monitoring device (1) can perform an individual operation.
    Type: Grant
    Filed: November 30, 2013
    Date of Patent: March 5, 2019
    Assignee: Nikkiso Company Limited
    Inventors: Masaru Kuchiki, Hiroaki Suzuki, Harutoshi Okabe
  • Patent number: 10168324
    Abstract: The present invention relates to a test system or an assay system (detection system) and test method preferably for use in the Point-of-Care (PoC) field.
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: January 1, 2019
    Assignee: DST DIAGNOSTISCHE SYSTEME & TECHNOLOGIEN GMBH
    Inventors: Marc Dangers, René Rübenhagen