Biological Fluid (e.g., Blood, Urine, Etc.) Patents (Class 210/645)
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Patent number: 12042590Abstract: A system for preparing a cancer vaccine (and optionally purifying the blood) has a blood filtration system, controlled by a processing unit, for filtering exogenous blood plasma to isolate tumor cells, tumor stem cells and tumor breakdown products. The blood filtration system filter includes multiple layers having differently sized apertures to retain differently sized materials (from among (i) tumor cells of different sizes, (ii) tumor stem cells and (iii) tumor DNA or other breakdown products. A device directs electromagnetic radiation at the isolated tumor cells, tumor stem cells and tumor DNA (or other breakdown products). The electromagnetic radiation may cause at least one of the (i) isolated tumor cells, (ii) isolated tumor stem cells, (iii) isolated tumor protein or breakdown products of the cells such as DNA to have a coagulated outer layer or a coagulated outer surface. The electromagnetic radiation may have a UV wavelength. A conical coil improves blood flow rate uniformity.Type: GrantFiled: April 2, 2023Date of Patent: July 23, 2024Inventors: David Michaeli, Menashe Michaeli
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Patent number: 11857713Abstract: An automated peritoneal dialysis system and machine configured to perform dextrose mixing are disclosed. An example dialysis machine includes a pump, a first solution having a first formulation stored in a first container that is placed in fluid communication with the pump, and a second solution having a second formulation stored in a second container that is also placed in fluid communication with the pump. The first container has a first unique identifier indicative of the first formulation and the second container has a second unique identifier indicative of the second formulation. The dialysis machine also includes a logic implementer programmed to receive a therapy prescription and operate the pump if the first formulation indicated by the first unique identifier is specified by the therapy prescription, or the second formulation indicated by the second unique identifier is specified by the therapy prescription.Type: GrantFiled: February 17, 2020Date of Patent: January 2, 2024Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Robert W. Childers, Alex Anping Yu, Borut Cizman
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Patent number: 11690946Abstract: A blood treatment apparatus is disclosed. The example apparatus includes a blood treatment unit including a fluid inlet and a fluid outlet and a blood line. The apparatus also includes a fluid line including an upstream fluid line configured to receive electrically conductive treatment fluid from a fluid source and pass the electrically conductive treatment fluid to the fluid inlet of the blood treatment unit and a downstream fluid line connected to the fluid outlet of the blood treatment unit for delivering the used electrically conductive treatment fluid to a fluid sink. The apparatus further includes a flow divider arranged in the downstream fluid line and configured to separate the used electrically conductive treatment fluid in the downstream fluid line into to a first fluid section and a second fluid section, thereby electrically isolating the first and second fluid sections.Type: GrantFiled: April 28, 2021Date of Patent: July 4, 2023Assignee: Gambro Lundia ABInventors: Per Hansson, Thomas Hertz, Mattias Holmer, Lennart Jonsson, Anders Nilsson, Anders Wallenborg, Johan Andersson
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Patent number: 11672895Abstract: A dialysis method to enable a patient to undergo both peritoneal dialysis and extracorporeal blood treatments is disclosed. The method includes determining, via a base unit controller, whether a peritoneal dialysis treatment or an extracorporeal blood treatment is to be performed. If the peritoneal dialysis treatment is to be performed, the method includes operating first software instructions that cause a base unit to use a first fluid stored in a fluid container. If the extracorporeal blood treatment is to be performed, the method includes operating second software instructions that cause the base unit to use a second, different fluid from an online source and selectively move the second, different fluid to a blood treatment unit for use in the extracorporeal blood treatment. The blood treatment unit is operable with the base unit to perform the extracorporeal blood treatment on a patient.Type: GrantFiled: June 28, 2021Date of Patent: June 13, 2023Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Gino Cicchello, Christian Bernard, Robert W. Childers, Anthony Simiele
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Patent number: 11571504Abstract: An apparatus and method for the batch photoactivation of mononuclear cells (MNCs) is described. The system includes a programmable controller configured to automatically separate whole blood in a first collection cycle to obtain a first quantity of MNCs; separate whole blood in a second collection cycle to obtain a second quantity of MNCs while simultaneously photoactivating the first quantity of MNCs to obtain a first quantity of treated MNCs; either store the first quantity of treated MNCs or reinfuse the first quantity of treated MNCs; photoactivate the second quantity of MNCs to obtain a second quantity of treated MNCs; either store the second quantity of treated MNCs or reinfuse the second quantity of treated MNCs; and reinfuse any blood components remaining after the second collection cycle.Type: GrantFiled: March 21, 2019Date of Patent: February 7, 2023Assignee: Fenwal, Inc.Inventors: Katherine N. Radwanski, Lan T Nguyen
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Patent number: 11439736Abstract: A dialysis system includes a dialysis machine including at least one pump positioned and arranged to pump a dialysis fluid; and a dialysis fluid source located separate from and in fluid communication with the dialysis fluid machine, the dialysis fluid source including a purified water line for carrying purified water, a source of a first concentrate, a source of a second concentrate, a first concentrate pump positioned and arranged to pump first concentrate from the first concentrate source, and a second concentrate pump positioned and arranged to pump second concentrate from the second concentrate source, wherein dialysis fluid is prepared for delivery from the dialysis fluid source to the dialysis machine by mixing the purified water with the first concentrate pumped by the first concentrate pump and the second concentrate pumped by the second concentrate pump.Type: GrantFiled: April 16, 2019Date of Patent: September 13, 2022Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Justin B. Rohde, Shincy J. Maliekkal
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Patent number: 11360076Abstract: Sample processing methods and systems to collect a biological sample. A device may be configured collect a predetermined volume of a sample in sample chamber, and seal the chamber upon activation. The device may be further configured to mix the mix the sample with a predetermined volume of a reagent and/or mix the sample and the reagent in a pre-determined ration.Type: GrantFiled: January 8, 2019Date of Patent: June 14, 2022Assignee: WEAVR HEALTH CORP.Inventors: Brandon T. Johnson, Kate E. Christian, Glenn H. Verner, Daniel Morgan
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Patent number: 11358138Abstract: A blood sample collection and/or storage device includes a two-piece housing that encompasses a port at which a fingertip blood sample is collected. After the sample is taken, the two-piece housing is moved to a closed position to protect the sample for storage and optionally process the sample.Type: GrantFiled: October 19, 2018Date of Patent: June 14, 2022Assignee: BOSTON MICROFLUIDICS INC.Inventor: Brandon T. Johnson
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Patent number: 11331667Abstract: An apparatus and method are disclosed for modifying the position of particles distributed in a fluid flow in a channel, comprising a channel formed by two substrates, each of the two substrates being on opposite sides of the channel, each substrate having a preselected periodic profile pattern along a length of the channel, and a transducer, wherein one of the substrates is between the transducer and the channel, the transducer to generate an acoustic standing wave within the channel with at least one node or antinode positioned within the channel.Type: GrantFiled: July 17, 2018Date of Patent: May 17, 2022Assignee: Nokia Technologies OyInventors: Ian Davis, Kevin Nolan
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Patent number: 11298446Abstract: A method is provided for calibrating a pump during a blood separation procedure that has at least a first and second state or phase where fluid is flowed to or from a reservoir by action of the pump. The state or phase of the procedure may be a priming state, a draw state, a separation state and a return state, and the pump calibration may be performed between consecutive performances of the same procedure state. The calibration is based on a variance between the volume of fluid predicted to be processed by the pump for the given state of the procedure and the actual volume processed based on the change of weight of the reservoir. Recalibration of the pump, if necessary, is accomplished before the performance of the second phase is commenced.Type: GrantFiled: December 19, 2014Date of Patent: April 12, 2022Assignee: Fenwal, Inc.Inventors: Samantha M. Planas, Amit J. Patel, Kathleen M. Higginson
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Patent number: 11253801Abstract: The prevent invention addresses the problem of providing a filter cloth for a bag filter, which has excellent collection efficiency, has excellent collection efficiency, provides low pressure drop and is resistant to clogging, and also has excellent dust-off ability; a method for producing the same; and a bag filter. As a means for resolution, a nonwoven fabric containing an ultrafine fiber having a fiber diameter D of 200 to 2,000 nm is laminated on a base material to form a filter cloth for a bag filter.Type: GrantFiled: November 4, 2016Date of Patent: February 22, 2022Assignee: TEIJIN FRONTIER CO., LTD.Inventors: Mie Kamiyama, Yoshikazu Kobayashi, Kazuyoshi Sakita
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Patent number: 10980934Abstract: A method for collecting plasma includes determining the weight, height, and hematocrit of a donor, and calculating a donor plasma volume and a target plasma collection volume. The target plasma collection volume is based on the donor plasma volume and a target percentage of plasma. The method then withdraws blood from the donor through a line connected to a blood component separation device, and introduces anticoagulant into the withdrawn blood. The blood component separation device separates the blood into a plasma component and a second blood component, and the plasma component is collected from the blood component separation device and into a plasma collection container. The method may then calculate the volume of pure plasma collected within the plasma collection container, and continue processing/collecting until the calculated volume of pure plasma equals the target plasma collection volume.Type: GrantFiled: July 16, 2020Date of Patent: April 20, 2021Assignee: HAEMONETICS CORPORATIONInventor: Michael Ragusa
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Patent number: 10906042Abstract: A new method is disclosed for extracting plasma from whole blood and metering the amount of plasma to an exact volume for dispensing into a diagnostic test, in a fully automatic and self-contained device. The device can be used in resource limited settings by unskilled users to facilitate sophisticated medical diagnostic testing outside of a hospital, clinic or laboratory.Type: GrantFiled: July 18, 2016Date of Patent: February 2, 2021Assignee: GattaCo Inc.Inventor: Michael Ryan McNeely
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Patent number: 10850235Abstract: Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. The method may include the steps of withdrawing fluid comprising CSF, filtering the volume into permeate and retentate by passing the fluid through a tangential flow filter, and returning the permeate to the subject. During operation of the system, various parameters may be modified, such as flow rate.Type: GrantFiled: June 9, 2016Date of Patent: December 1, 2020Assignee: MINNETRONIX, INC.Inventors: Emily Rolfes Meyering, Gary Seim, Abhi Vase, Ben Krehbiel, Blake Hedstrom, Aaron McCabe
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Patent number: 10807068Abstract: A sorbent pouch for use in sorbent dialysis. The sorbent pouch allows for fluid to freely pass into and through the sorbent materials, while keeping the sorbent materials inside the sorbent pouch.Type: GrantFiled: March 28, 2018Date of Patent: October 20, 2020Assignee: Medtronic, Inc.Inventors: Martin T. Gerber, Christopher M. Hobot
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Patent number: 10751251Abstract: A medical preparation dividing method is dividing a medical preparation stored in a storage member into a plurality of division bags by gravitational force through a primary tube, a branch portion, and a plurality of branch tubes. A medical preparation dividing unit has a curved portion formed in another end side of the primary tube, an inlet of the branch portion arranged above the curved portion, and outlets of the branch portion arranged above the inlet, in a state where the plurality of division bags is held with a holding tool.Type: GrantFiled: September 20, 2017Date of Patent: August 25, 2020Assignee: Terumo Kabushiki KaishaInventors: Kaoru Hosoe, Koudai Nagata
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Patent number: 10617809Abstract: An electrical sensor for sensing electromagnetic properties of process fluids in a dialysis machine or a similar medical device can include a probe for interfacing with the fluids that is made from electronic fabric materials. The electronic fabric probe can include one or more conductors embedded in a non-conductive fabric layer. The electronic fabric probe is accommodated an enclosure which establishes a flow path with respect to the probe to establish fluid contact between the process fluids and the conductors. The conductors can apply or sense current and/or voltage with respect to the fluid. A portion of the electronic fabric probe can be disposed externally of the enclosure to provide electronic communication externally of the enclosure.Type: GrantFiled: December 29, 2016Date of Patent: April 14, 2020Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Colin Weaver, Elliott Alber, Philip Scott James, Daniel Schmidt
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Patent number: 10426883Abstract: A hemodialysis system configured to purge air from a blood circuit comprising: a dialyzer; a dialysis fluid circuit operable with the dialyzer via dialysis fluid inlet and outlet lines; the blood circuit operable with the dialyzer and including an arterial line, a venous line, a blood pump operable with the arterial line upstream of the dialyzer, and a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump; and an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, air is purged using dialysis fluid or other physiologically acceptable fluid pumped by at least one of the fresh or used dialysis fluid pumps from the dialysis fluid circuit, through the dialyzer, into the blood circuit, in combination with dialysis fluid or other physiologically acceptable fluid from the source introduced directly into the blood circuit.Type: GrantFiled: February 8, 2019Date of Patent: October 1, 2019Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
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Patent number: 10391228Abstract: A hemodialysis system configured to purge air from a blood circuit comprises a dialyzer; a dialysis fluid circuit operable with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including a fresh dialysis fluid pump, and a used dialysis fluid pump; the blood circuit operable with the dialyzer and including an arterial line, a venous line, a blood pump operable with the arterial line upstream of the dialyzer, a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump, a drip chamber located along the venous line, and a container for accepting air purged from the blood circuit; and an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, the blood pump pumps a fluid through the dialyzer and into the drip chamber, forcing air from the drip chamber into the container.Type: GrantFiled: February 8, 2019Date of Patent: August 27, 2019Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Thomas D. Kelly, Marc S. Minkus, Angelito A. Bernardo, William P. Burns, Robert W. Childers, Shincy J. Maliekkal, Matthew R. Muller, Justin B. Rohde, Michael E. Hogard
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Patent number: 10378693Abstract: There is disclosed a condensate drain, comprising: a body defining a drain chamber having a liquid-gas inlet and a liquid outlet; and a porous membrane having a pore size of about 0.2 ?m or less disposed within the body between the liquid-gas inlet and the liquid outlet; wherein in use, the porous membrane permits liquid to pass therethrough but restricts the passage of gas.Type: GrantFiled: August 20, 2015Date of Patent: August 13, 2019Assignee: Spirax-Sarco LimitedInventors: Jeremy Miller, Brian Chu, Kevin Rushbrooke, Simon Geuley
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Patent number: 10342911Abstract: An apparatus for extracorporeal blood treatment, comprising a treatment unit (2) having a first chamber (3) and a second chamber (4) separated from one another by a semipermeable membrane (5), a blood removal line (6) connected in inlet with the first chamber (3) and a blood return line (7) connected in outlet with the first chamber; an infusion line (9; 9a, 9b) of a replacement fluid and a fluid evacuation line (10) connected in outlet from the second chamber.Type: GrantFiled: November 17, 2016Date of Patent: July 9, 2019Assignee: Gambro Lundia ABInventors: Mauro Suffritti, Michela Carpani
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Patent number: 10272363Abstract: An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis. The system is configured to allow insertion of a urease pouch, injection of a urease solution, or addition of a urease cartridge, into a dialysis cabinet containing a dialysis flow loop. The urease can be dissolved and the resulting urease solution added to the sorbent cartridge in the flow loop to replenish the urease within the sorbent cartridge. The sorbent cartridge can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.Type: GrantFiled: March 9, 2015Date of Patent: April 30, 2019Assignee: MEDTRONIC, INC.Inventors: Martin T. Gerber, Christopher M. Hobot
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Patent number: 10265459Abstract: An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit (10) is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line. The value of the effectiveness parameter is calculated using one or more values representative of the conductivity in the spent dialysate line obtained relying on a mathematical model.Type: GrantFiled: March 5, 2018Date of Patent: April 23, 2019Assignee: GAMBRO LUNDIA ABInventors: Francesco Fontanazzi, Alessandro Surace, Francesco Rosati
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Patent number: 10245369Abstract: A method for priming a hemodialysis treatment includes: providing a disposable cassette including at least a portion of a dialysate circuit and at least a portion of a blood circuit; placing a dialyzer in fluid communication with the dialysate circuit via a to-dialyzer dialysate line and a from-dialyzer dialysate line; placing the dialyzer in fluid communication with the blood circuit via an arterial blood line and a venous blood line; placing a source of dialysis fluid in fluid communication with the dialyzer; priming the dialysate circuit with dialysis fluid from the source while both the to-dialyzer dialysate line and the from-dialyzer dialysate line are connected at their dialyzer ends to the dialyzer; and priming the blood circuit with dialysis fluid from the source by actuating at least one valve provided by the disposable cassette.Type: GrantFiled: May 24, 2016Date of Patent: April 2, 2019Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
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Patent number: 10226543Abstract: There is provided an allergen inactivating agent having less lowering in performance due to fluctuation in pH, and being capable of not only adsorbing and removing an allergen, but also inactivating and removing the allergen itself. In addition, there is provided a house dust treatment agent, spray, and sheet, capable of effectively removing house dust, without any disadvantages upon use such as generation of stains.Type: GrantFiled: March 17, 2006Date of Patent: March 12, 2019Assignee: FUMAKILLA LIMITEDInventors: Shinichi Nagai, Takashi Sugiyama
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Patent number: 10201650Abstract: An apparatus and method are disclosed for detecting the disconnection of a vascular access device such as a needle, cannula or catheter from a blood vessel or vascular graft segment. A pair of electrodes is placed in direct contact with fluid or blood in fluid communication with the vascular segment. In one embodiment, the electrodes are incorporated into a pair of connectors connecting arterial and venous catheters to arterial and venous tubes leading to and from an extracorporeal blood flow apparatus. Wires leading from the electrodes to a detecting circuit can be incorporated into a pair of double lumen arterial and venous tubes connecting the blood flow apparatus to the blood vessel or vascular graft. The detecting circuit is configured to provide a low-voltage alternating current signal to the electrodes to measure the electrical resistance between the electrodes, minimizing both the duration and amount of current being delivered.Type: GrantFiled: October 23, 2014Date of Patent: February 12, 2019Assignee: DEKA Products Limited PartnershipInventors: Michael J. Wilt, Jason M. Sachs
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Patent number: 10124274Abstract: An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis using urease pouches. The sorbent cartridge is configured to allow insertion of a urease pouch or injection of a urease solution into the sorbent cartridge containing a urease pouch. The sorbent module can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.Type: GrantFiled: March 11, 2015Date of Patent: November 13, 2018Assignee: Medtronic, Inc.Inventors: Martin T. Gerber, Christopher M. Hobot
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Patent number: 10076283Abstract: A system and method for determining the amount of fluid to be removed from a dialysis patient is disclosed. The system utilizes sensors and a computer. The computer obtains the input parameters from the sensors, along with information added directly by the user, and performs a forward algorithm to determine a recommended change in patient fluid level. As fluid is removed, the effect of the removal on the parameters is detected by the sensors and re-transmitted back to the computer. The computer then performs a backward algorithm to refine the variables used in the forward algorithm and obtain more accurate results. The system and method provide for changing the amount of fluid removed from the patient based on the results of the algorithm and the data received from the sensors.Type: GrantFiled: November 12, 2014Date of Patent: September 18, 2018Assignee: Medtronic, Inc.Inventors: Orhan Soykan, Christopher M. Hobot, Martin T. Gerber, VenKatesh R. Manda
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Patent number: 10016553Abstract: An apparatus and method for replenishing urease in a sorbent cartridge for use in sorbent dialysis. The sorbent cartridge is configured to allow an amount of urease to be added to the sorbent cartridge. A urease solution can be injected into the sorbent cartridge to replenish the urease containing module, or solid urease can be added to the sorbent cartridge. The sorbent module can also comprise other, rechargeable, sorbent materials for removing toxins other than urea from spent dialysate.Type: GrantFiled: February 27, 2015Date of Patent: July 10, 2018Assignee: MEDTRONIC, INC.Inventors: Martin T. Gerber, Christopher M. Hobot
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Patent number: 9968721Abstract: A method includes monitoring an indicator of fluid volume of a patient via a sensor device, and setting an initial fluid volume removal prescription for a blood fluid removal session based on the monitored indicator of fluid volume. The method may further include transmitting data regarding the indicator of fluid volume from the implantable sensor device to fluid removal device. The system includes a blood fluid removal device and control electronics configured to set the initial fluid removal volume and rate prescription. In some embodiments, the fluid removal device sets or calculated the initial fluid volume removal prescription based on the data received from the implantable sensor. The indicator of fluid volume may be an indicator of tissue fluid volume or an indicator of blood fluid volume.Type: GrantFiled: November 26, 2014Date of Patent: May 15, 2018Assignee: MEDTRONIC, INC.Inventors: Martin Gerber, John Burnes, Suping Lyu, VenKatesh R. Manda, Bryant Pudil
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Patent number: 9950105Abstract: A blood treatment machine includes a blood pump; an arterial line in fluid communication with the blood pump, the arterial line including an arterial needle; a venous line including a venous needle; and a blood leak detection device including (i) at least one electrical component, (ii) a member configured to secure the at least one electrical component onto a patient's arm adjacent to patient access of at least one of the arterial and venous needles, the at least one electrical component capable of sensing the presence of a blood leak, and (iii) a controller in operable communication with the at least one electrical component, the controller programmed to allow for an amount of expected blood seepage and to cause an alarm if blood greater than the amount of expected blood seepage is sensed by the at least one electrical component.Type: GrantFiled: May 27, 2016Date of Patent: April 24, 2018Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Rodolfo Roger, Robert Childers, Thomas D. Kelly
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Patent number: 9943636Abstract: An apparatus for extracorporeal treatment of blood (1) comprising a treatment unit, a blood withdrawal line, a blood return line, a preparation line and a spent dialysate line. A control unit (10) is configured to calculate values of a parameter relating to treatment effectiveness based on measures of the conductivity in the spent dialysate line. The value of the effectiveness parameter is calculated using one or more values representative of the conductivity in the spent dialysate line obtained relying on a mathematical model.Type: GrantFiled: October 28, 2013Date of Patent: April 17, 2018Assignee: GAMBRO LUNDIA ABInventors: Francesco Fontanazzi, Alessandro Surace, Francesco Rosati
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Patent number: 9943631Abstract: A system and method for determining a concentration of total chlorine in dialysis water are provided. The system comprises a main unit housing a KI/water sample chamber and a sodium sulfate chamber. A first electrode pair bridges the two chambers and generates tri-iodide proportional to the amount of total chlorine in the water sample. A second electrode pair in contact with fluid in the KI/water sample detects an amount of tri-iodide generated by the first electrode pair. The system is suitable for use in connection with, or for incorporation into, a water purification system for generating dialysis fluid, and may include a display that alerts the user to stop or prevent a hemodialysis treatment if the total chlorine level exceeds a predetermined level.Type: GrantFiled: August 5, 2015Date of Patent: April 17, 2018Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Jeff White, Ye Chen, Yuanpang Samuel Ding, Joel Titus, Justin Rohde, Shincy Maliekkal, Kevin Cooper
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Patent number: 9937285Abstract: A system and method for determining a concentration of total chlorine in dialysis water are provided. The system comprises a main unit housing an iodide/water sample chamber and a reducing agent chamber. An electrode pair bridges the two chambers and generates tri-iodide proportional to the amount of total chlorine in the dialysis water. The electrode pair detects the amount of tri-iodide generated in proportion to the amount of active chloride in the dialysis water. The system is suitable for use in connection with, or for incorporation into, a water purification system for generating dialysis fluid, and may include a display that alerts the user to stop or prevent a hemodialysis treatment if the total chlorine level exceeds a predetermined level.Type: GrantFiled: September 25, 2015Date of Patent: April 10, 2018Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Jeff White, Ye Chen, Yuanpang Samuel Ding, Joel Titus, Justin Rohde, Shincy Maliekkal, Kevin Cooper
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Patent number: 9927416Abstract: The present application relates to a method for controlling a disinfection status of a heater and/or cooler for human body temperature control during extracorporeal circulation. The temperature control is conducted by use of a heat exchanger and a temperature control liquid circulating through the heat exchanger and the heater and/or cooler. The inventive method comprises using a long term disinfectant in the temperature control liquid, measuring and preferably recording the concentration of the disinfectant in the temperature control liquid and deducing a disinfectant status of the temperature control liquid from the measured concentration of the disinfectant in the temperature control liquid.Type: GrantFiled: January 27, 2016Date of Patent: March 27, 2018Assignee: Sorin Group Deutschland GmbHInventors: Johann Schreyer, Erwin Knott
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Patent number: 9889245Abstract: A highly reliable circulation apparatus promptly detects an abnormal state of a status value related to blood flowing in a circulation circuit with no particular operation performed. As an extracorporeal circulation mode starts, a user operates a pump first and waits until a flow rate is stabilized. Then, when the flow rate is stabilized, a predetermined value is added to or subtracted from the stabilized flow rate so as to set two threshold values which regulate an upper end and a lower end of a permissible state range. Then, it is monitored whether or not the flow rate is within the permissible state range regulated by the threshold values, and when the flow rate deviates from the permissible state range, an alarm is issued for notification.Type: GrantFiled: September 29, 2015Date of Patent: February 13, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Tomoki Utsugida, Ryosuke Hanai
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Patent number: 9889243Abstract: A hemodialysis system comprising: a source of priming fluid; an extracorporeal circuit including an arterial line, a venous line, and a drip chamber; a level sensor operable with the drip chamber; a reversible blood pump operable with the extracorporeal circuit; a connection between the arterial and the venous line; and a priming sequence in which priming fluid from the source is pumped in a reverse pump direction through the extracorporeal circuit and reversibly in a normal pump direction through the extracorporeal circuit, wherein an output from the level sensor is used to determine when to stop pumping in at least one of the directions.Type: GrantFiled: October 12, 2016Date of Patent: February 13, 2018Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Thomas Kelly, Robert W. Childers, Don Busby, Rodolfo Roger, Waleed Mutasem El Sayyid, Shahid Din
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Patent number: 9867920Abstract: An Oxygenator as a medical instrument includes at least one first hollow fiber membrane layer comprised of a plurality of integrated first hollow fiber membranes, and forms a shape of a cylindrical body as a whole, and at least one second hollow fiber membrane layer disposed at the outer circumferential side of the first hollow fiber membrane layer in a state of being concentric with the first hollow fiber membrane layer, has a plurality of integrated second hollow fiber membranes, and forms a shape of a cylindrical body as a whole. Moreover, each of the first hollow fiber membranes is wound around a central axis, and each of the second hollow fiber membranes is wound around a central axis. The number of times the second hollow fiber membranes are wound is smaller than the number of times the first hollow fiber membranes are wound.Type: GrantFiled: September 24, 2014Date of Patent: January 16, 2018Assignee: TERUMO KABUSHIKI KAISHAInventors: Kazuhiko Takeuchi, Eisuke Sasaki
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Patent number: 9821107Abstract: This invention relates to dialysis systems and methods. In some implementations, a method includes applying vacuum pressure to a device of a dialysis system, and then determining, based on a detected fluid level or measured pressure, whether the device is functioning properly.Type: GrantFiled: December 10, 2015Date of Patent: November 21, 2017Assignee: Fresenius Medical Care Holdings, Inc.Inventors: Colin Weaver, Martin Joseph Crnkovich
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Patent number: 9795731Abstract: An air purging method includes: (a) detecting a low fluid level in a blood circuit indicating a high amount of air in the blood circuit; (b) stopping a blood pump; (c) closing a venous patient line; (d) opening a blood circuit air vent valve and a drain valve; and (e) running the blood pump to meter air through the air vent valve and the drain valve to a drain.Type: GrantFiled: July 30, 2014Date of Patent: October 24, 2017Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Thomas D. Kelly, Marc S. Minkus, Angelito A. Bernardo, William P. Burns, Robert W. Childers, Shincy J. Maliekkal, Matthew R. Muller, Justin B. Rohde, Michael E. Hogard
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Patent number: 9757095Abstract: The present invention generally relates to devices and methods for collecting and stabilizing biological samples, and more particularly, for collecting and stabilizing blood or other bodily fluids from a user's fingertip, earlobe, heel or other locations. The present invention also relates to sample collection devices that simplify the process for mixing the biological samples with an additive or additives, provide for efficient storage and safe transport of the samples, and provide for easy access to the samples for subsequent processing.Type: GrantFiled: June 10, 2015Date of Patent: September 12, 2017Assignee: DXTERITY DIAGNOSTICS INCORPORATEDInventors: Robert Terbrueggen, Scott Gordon Beach
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Patent number: 9744284Abstract: A method for a hybrid blood and peritoneal dialysis (“PD”) machine comprising: (i) determining whether a previous treatment left a last fill of dialysate in a patient's peritoneum; (ii) if a next treatment is a PD treatment, and if the previous treatment did not leave the last fill of dialysate, causing a PD treatment in which a first cycle is a fill cycle to be initiated; (iii) if the next treatment is a PD treatment, and if the previous treatment did leave the last fill of dialysate, causing a PD treatment in which a first cycle is a last fill drain cycle to be initiated; and (iv) if the next treatment is a blood treatment and if the previous treatment did leave the last fill of dialysate, causing a blood treatment including a last fill drain cycle to be initiated.Type: GrantFiled: December 28, 2015Date of Patent: August 29, 2017Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Gino Cicchello, Christian Bernard, Robert W. Childers, Anthony Simiele
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Patent number: 9737653Abstract: A system and method provide improved ultrafiltration of charged/uncharged solutes in a fluid, especially a body fluid. The improvement is achieved through imposed electric field and/or surface charge patterning to a permeable membrane. In many of the embodiments, at least one selected material is used as an additive on a permeate side of the permeable membrane to reduce the sieving coefficient of the membrane with regard to a solute present in the fluid.Type: GrantFiled: August 1, 2011Date of Patent: August 22, 2017Inventors: Albert Terrence Conlisk, Jr., Subhra Datta, William H. Fissell, Shuvo Roy
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Patent number: 9731061Abstract: A method and a device for monitoring an extracorporeal blood flow during an extracorporeal blood treatment with an extracorporeal blood treatment device. The extracorporeal blood treatment device may include the device for monitoring an extracorporeal blood flow. The arterial and/or venous patient access is monitored with a first and a second method, each of which there is a check for a presence of at least one criterion that is characteristic of a condition of the vascular access that is not in proper order, the criteria for the first and second methods being distinguished from one another. A blood pump, which is preferably an occlusion blood pump, is stopped once the presence of the at least one criterion of the first method has been established, while a venous cut-off unit remains open. Once the blood pump has been stopped, the presence of the at least one criterion is checked with the second method. The venous cut-off unit is not closed until the at least one criterion for the second method is present.Type: GrantFiled: May 16, 2014Date of Patent: August 15, 2017Assignee: Fresenius Medical Care Deutschland GmbHInventors: Pascal Kopperschmidt, Thomas Núrnberger
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Patent number: 9718003Abstract: A centrifuge tube assembly which allows for a single centrifuge cycle and which permits the aspiration of fluids from multiple levels with the centrifuge tube assembly. A modified centrifuge assembly is described wherein the inner tube has an externally threaded portion at its upper end. The method of using the centrifuge tube assembly is also described wherein the centrifuge tube assembly may be used for the aspiration, separation, isolation and extracting of discrete layer in a liquid suspension.Type: GrantFiled: April 7, 2015Date of Patent: August 1, 2017Assignee: CELLMEDIX HOLDINGS, LLCInventor: Thomas R. Petrie, Jr.
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Patent number: 9663813Abstract: A method for filtering a sample comprising the steps of: (a) providing a sample with eukaryotic cells and containing or suspected to contain a micro-organism; (b) performing a selective lysis of the eukaryotic cells to obtain a lysed sample; (c) filtering the lysed sample obtained in step (b) through a filter arranged to retain the micro-organism; and (d) washing the filter with a detergent based wash buffer to selectively solubilize proteins originating from the eukaryotic cells retained by the filter, by passing the detergent based wash buffer through the filter, to remove protein clogs from the filter in order to allow an additional step (c) of filtering said lysed sample.Type: GrantFiled: June 26, 2013Date of Patent: May 30, 2017Assignee: Biocartis NVInventors: Roel Penterman, Bart Van Meerbergen
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Patent number: 9629951Abstract: An apparatus for performing blood therapy having a plurality of pumps for engaging blood and fluid tubing is characterized by a plurality of manually mounted and disengagable panels installed on the sides of the apparatus housing, the panels having pump engaging tubing mounted on the inside of the respective panels.Type: GrantFiled: April 22, 2014Date of Patent: April 25, 2017Assignee: B. BRAUN AVITUM AGInventors: J. Michael Delmage, Harold W. Peters, Tommy Cooper
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Patent number: 9630179Abstract: System, apparatuses, and methods for performing automated reagent-based analysis are provided. Also provided are methods for automated attachment of a cap to a reaction receptacle, and automated removal of a cap from a capped reaction receptacle.Type: GrantFiled: August 27, 2015Date of Patent: April 25, 2017Assignee: GEN-PROBE INCORPORATEDInventors: Byron J. Knight, Julian Groeli
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Patent number: 9617532Abstract: The present invention relates to a lysis, binding and/or wash reagent for isolating and/or purifying nucleic acids and a method for isolating and/or purifying nucleic acids.Type: GrantFiled: May 25, 2009Date of Patent: April 11, 2017Assignee: QIAGEN GmbHInventors: Roland Fabis, Anke Homann-Wischinski, Thorsten Voss, Thomas Hanselle
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Patent number: 9610579Abstract: This document provides devices, systems, and methods for delivering fluids. In some cases, the devices, systems, and methods include a deformable reservoir being at least partially defined by rigid plastically-deformable web. An actuator can press against said rigid plastically-deformable web to plastically deform said web. In some cases, a controller is adapted to receive a cartridge including a deformable reservoir and control the pressing of an actuator against a rigid plastically-deformable web to deliver fluid from the deformable reservoir.Type: GrantFiled: January 6, 2015Date of Patent: April 4, 2017Assignee: Daktari Diagnostics, Inc.Inventors: Aaron Oppenheimer, Lutz Weber, Matthias Kronsbein, Zachary Jarrod Traina, Philip Charles Walker, Andrew Boyce, Adam Casey