Abstract: Various aspects of the subject disclosure relate to a compounder system having a cartridge that includes fluid pathways controllable by valves of the cartridge. A pump component within the cartridge is actuable to move fluid through the controllable fluid pathways. The cartridge includes a needle extending from a cartridge body and fluidly coupled to at least one of the controllable fluid pathways. A vial puck is provided for attachment to a vial to be fluidly coupled to the cartridge by the needle. The vial puck may include a hygroscopic member to absorb fluid from the needle to ensure a dry disconnect. A shuttle valve may also be provided.

Abstract: Vessel closure assemblies are provided. The vessel closure assemblies may be engaged with vessels. The vessel closure assemblies may each include a vessel closure, inserts such as anchors and fluid conduits extending through the vessel closure, and a respiratory assembly. The respiratory assembly may include a housing and one or more gas permeable membranes. The gas permeable membranes may be oriented substantially perpendicular to a top wall of the vessel closure through which the inserts extend.

Abstract: A container-closure system includes a container configured to hold a therapeutic liquid and having a dispensing tip configured to dispense a dose of the therapeutic liquid. A vented cap is configured to fit over at least a portion of the container including the dispensing tip and having one or more vents that allow air to pass into and out of a cavity defined between the vented cap and the dispensing tip. A second cap is configured to fit over at least a portion of the vented cap. A tamper evident seal is coupled to the second cap and one or both of the container and the vented cap.

Abstract: A combined tube set for a disposable water bottle for an endoscope includes a cap with threads suitable for attachment to various water bottles. The combined tube set provides a first tube set for rinsing that includes an air and water tubes, air/water connector, and anchor. The combined tube set also provides a second tube set for irrigation that includes an irrigation connector, backflow valve(s), and flexible tubing section.

Abstract: A combined tube set for a disposable water bottle for an endoscope includes a cap with threads suitable for attachment to various water bottles. The combined tube set provides a first tube set for rinsing that includes an air and water tubes, air/water connector, and anchor. The combined tube set also provides a second tube set for irrigation that includes an irrigation connector, backflow valve(s), and flexible tubing section.

Abstract: A device and related method are provided for lyophilizing a substance within the device and storing therein the lyophilized substance. The device is penetrable by a needle for filling the device with the substance to be lyophilized, and a resulting needle hole in the device is laser resealable by transmitting thereon laser radiation from a laser source. The device defines a chamber for receiving therein the substance to be lyophilized. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber with the substance to be lyophilized through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation thereto.

Abstract: Disclosed is a uniquely configured medicament vial assembly which includes a storage vial, a stopper member and a securing ring. The vial assembly is configured to improve healthcare worker safety by providing a shielded gripping location to aid in the reduction of accidental needle sticks. The storage vial has a body portion which defines an interior chamber for storing a predetermined medicament and a neck portion through which medicament is received into and withdrawn from the interior chamber. The stopper member is inserted into the mouth of the vial and establishes a first seal. The securing ring is engaged with the mouth of the vial and adapted and configured for retaining the stopper member within the vial mouth and effectuating a second seal. The securing ring is formed from a thermoplastic and/or elastic material. Preferably, the securing ring is formed by molding the thermoplastic and/or elastic material over a portion of the storage vial and stopper member when engaged within the vial mouth.

Abstract: A pouring port of a container for liquid at one end of which a rubber stopper allowing the penetration of an injection needle therethrough is embedded, wherein: the pouring port is formed by welding a port part, at least the innermost layer of which forming the discharge channel thereof comprises a resin containing a COP-based resin as the main component, with a stopper body part, which holds the rubber stopper and comprises a resin containing a COP-based resin as the main component, via the resin layers containing the respective COP-based resins as the main component; and at least the resin constituting the stopper body part contains a rubber component in an amount of not more than 30% by mass, or has, in the main chain, a molecular structure represented by general formula (1) [wherein R represents a hydrogen atom or an organic group having 1 to 20 carbon atoms; and n represents an integer equal to or greater than 1] and contains a PE-based resin in an amount of 30% by mass or less, and/or contains an a

Abstract: A self-contained breathing closure for flasks and other containers that require gas exchange. An illustrative embodiment of the closure is comprised of a splashguard, an adaptor for attaching the closure to the container, a bellows element and a gas-permeable barrier element. The splashguard is intended to keep liquid contents under vigorous agitation in the container without wetting the gas-permeable barrier. The adaptor couples the closure to the container in a secure fashion. The bellows element allows for repeated changes in the internal volume of the container-closure system. The gas-permeable barrier allows desired gases to enter and leave the container while excluding small particles and/or microorganisms. The technology may be used with existing glass flask technology, or coupled to a plastic flask that may be configured for either single-use, or multiple-use.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: The present invention relates to containers suitable for uses such as liquid hot-fill processes. More specifically the invention relates a containers having gas permeable vents with an integral sealing means that is externally activatable by non-mechanical means to effect hermetic sealing of the containers after filling.

Abstract: A cap having a plurality of spaced-apart grooves in a downwardly tapered inner wall of the cap to facilitate the formation of air passageways as the cap is penetrated by a pipette tip. The air passageways aid in venting air from a fluid-holding vessel closed with the cap.

Abstract: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid transfer device to allow air to be vented from the vessel. At least a portion of the contents of the vessel is then drawn into the fluid transfer device before the fluid transfer device is removed from the vessel.

Abstract: A cap including a penetrable material adapted to be pierced by a fluid transfer device and an absorbent material positioned above the penetrable material. The absorbent material permits passage of the fluid transfer device and absorbs fluid material present on an outer surface of the fluid transfer device as it is being removed from the cap. The cap is useful for accessing the contents of an associated fluid-holding vessel multiple times.

Abstract: An assembly for culturing cells includes a housing defining a reservoir for containing cell culture media and an opening in fluid communication with the reservoir. The cell culture assembly further includes a filter valve assembly configured to sealingly engage the opening. The filter valve assembly includes a flexible membrane, a contiguous side wall, an end wall, and a microbial filter. The end wall has an opening and extends across one end of the side wall to form a major cavity within the side wall and the end wall. The flexible membrane has a slit spanning the membrane and is disposable within the major cavity such that the membrane sealingly divides the major cavity into (i) a chamber formed between the end wall and the membrane and (ii) a minor cavity formed by the membrane and a portion of the side wall. The minor cavity is in fluid communication with the reservoir.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals include a foil layer and are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.

Abstract: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device.

Abstract: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid transfer device to allow air to be vented from the vessel. At least a portion of the contents of the vessel is then drawn into the fluid transfer device before the fluid transfer device is removed from the vessel.

Abstract: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retaining structure. The retaining structure is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retaining structure may be penetrable by a fluid transfer device.

Abstract: A connector for use in connecting a container of liquid nutrients to an enteral feeding tube to supply the liquid nutrients to a patient includes an integrally formed spike projecting into a cavity defined by an interior surface of a body of the connector. An air passage in communication with the cavity extends through the spike to outside the connector. A filter is secured to the end of the passage outside the connector. The body of the connector is free of structure that both defines any portion of the liquid passage and is formed for penetrating the puncturable seal of the container.

Abstract: This invention provides cylindrical cell culture tubes with a cap having both a septum and gas exchange membranes. The culture tubes can be used to inoculate media, culture cells, harvest cells and store cells in the same container with reduced risk of contamination, while facilitating automated handling.

Abstract: A container closure system for use in lyophilization processes employing depressurization to initiate nucleation is provided. The present container closure system includes a container and a closure element disposed proximate to and adapted for sealing the opening of the container. The closure element includes a first sealing surface adapted for sealably contacting an interior surface of the container and a second sealing surface adapted for sealably contacting the top surface of the container when the container closure system is in a closed position. The closure element also includes a plurality of closure legs extending from the second sealing surface that define a plurality of side vents between each of the closure legs when the container closure system is in the open position. The length, thickness, number, and shape of the legs are chosen to produce an effective total side vent area that is at least 50% of the area of the container opening.

Abstract: A collection device comprising an open-ended vessel for receiving and holding a fluid substance and a cap configured to position a specimen retrieval device along an inner surface of the vessel when the cap is fixedly associated the vessel.

Abstract: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the cap has a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retainer. The retainer is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retainer may be penetrable by a fluid transfer device.

Abstract: A method for obtaining the contents of a fluid-holding vessel having a cap secured to an open end thereof. The method includes penetrating a surface of the cap with a fluid transfer device and forming one or more air passageways between the penetrated surface of the cap and the fluid transfer device to allow air to be vented from the vessel. At least a portion of the contents of the vessel is then drawn into the fluid transfer device before the fluid transfer device is removed from the vessel.

Abstract: A cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the cap has a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes a filter for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filter is positioned between the frangible seal and a retainer. The retainer is positioned on the cap above the filter and may be used to contain the filter within the cap. The material of the retainer may be penetrable by a fluid transfer device.

Abstract: A versatile vial and plug combination forming a securely sealed closure of the vial. The combination includes a vial with (a) a head with an inner diameter (ID) and an outer diameter (OD); (b) a body with an ID and an OD substantially equal to those of the head; and (c) a neck having an ID less than the ID, and an OD less than the OD, of the head and body, providing a recessed robotic arm pick up area adapted for engagement by automatic equipment. The combination also includes a resilient plug with (a) an inwardly tapered base, (b) a top flange, and (c) a body having an OD that corresponds to or is only slightly greater than the ID of the vial, assuring an interference fit between the plug and the vial, thereby sealing the plug inside the vial upon insertion of the plug in the vial.

Abstract: An injection molded assembly forming a sealing device for a threaded or non-threaded container using a double cap concept with pressure responsive convex sealing; also disclosed is a wiping mechanism, a one piece construction, a tamper resistant construction, a limited air exchange construction while allowing easy access to fluid contents, a sterile air venting and filter construction, a one piece tamper evident closure with a tethered container, and a frangible tether means molded with the formation of the sealing device.

Abstract: The present invention relates to a cap which can form an essentially leak-proof seal with an open-ended vessel capable of receiving and holding fluid specimens or other materials for analysis. To minimize potentially contaminating contact between a fluid sample present in the vessel and humans or the environment, the present invention features a cap having a frangible seal which is penetrable by a plastic pipette tip or other fluid transfer device. The cap further includes filtering means for limiting dissemination of an aerosol or bubbles once the frangible seal has been pierced. The filtering means is positioned between the frangible seal and retaining means. The retaining means is positioned on the cap above the filtering means and may be used to contain the filtering means within the cap. The retaining means may be comprised of a material which is penetrable by a fluid transfer device.

Abstract: A closure (20) for sealing a micro-organism container (50) is disclosed. The closure (20) includes a resilient seal (24) for sealing the container (50), a passageway (26) extending through the seal (24), or filter media (28) extending across the passageway (26) integrally molded to the seal (24) for allowing sterile gas exchange therethrough. A method of making a flask closure (20) is also disclosed. The method includes molding a sealing member (24) having a port (26) extending therethrough while simultaneously sealing a peripheral edge (31) of a filter media (28) within the passageway (26).

Abstract: A closure (20) for sealing a micro-organism container (50) is disclosed. The closure (20) includes a resilient seal (24) for sealing the container (50), a passageway (26) extending through the seal (24), or filter media (28) extending across the passageway (26) integrally molded to the seal (24) for allowing sterile gas exchange therethrough. A method of making a flask closure (20) is also disclosed. The method includes molding a sealing member (24) having a passageway (26) extending therethrough while simultaneously sealing a peripheral edge (31) of a filter media (28) within the passageway (26).

Abstract: A spotting tip includes a tip body which is fitted on the end of a nozzle for sucking liquid contained in a container and inserted into the liquid in the container through a mouth of the container, and a lid member which is brought into contact with the mouth of the container and closes the space between the tip and the edge of the mouth when the tip is inserted into the container to a predetermined depth. At least one fine communicating passage is formed in at least one of the lid member and the tip body to communicate the inside and outside spaces of the container on opposite sides of the lid member.

Abstract: A closure cap for sealing containers without gas bubbles displaces some of the contents of the container when fitted onto the neck of the container and at the same time allows any trapped gas to escape through one or more vents before the closure cap engages in the closure position.

Abstract: An apparatus to directly take a sample of expired air from a subject which utilizes a stopper (3) with two distinct position. When the stopper (3) is in the upper position, it allows air blown in via the cannula (6) to scavenge the interior space of the tube (1) until the control (11,12, or 13) has indicated a sufficient volume. The cannula (6) is then pulled by the operator so that a blind stop (7) obturates the opening of an evacuation pipe (10) connected to the control. The stopper is then moved to a lower position to seal the sample of air in the tube (1).

Abstract: The instant invention is a disposable water cooler bottle filtration device. The filtration device is situated within the well of a conventional water cooler and employs an elongated tube with a centrally disposed piercing tip. The tip provides for the puncturing of the water bottle cap when the water bottle is placed thereon. Water flowing through the tube passes through a sub-micron filter capable of removing bacteria. Optionally activated carbon may be placed within the support structure providing removal of chlorine and known carcinogenic formed by chlorine combined by-products.

Abstract: Stoppers for medicine vessels are disclosed. Such stoppers comprise an insert having one end frictionally engageable within an opening in a medicine vessel. Such inserts' other ends have a fitting, e.g. a luer complimentary with a luer on an opening in the medicine vessel. The fitting allows the contents of the medicine vessel to be withdrawn without using a sharp object, such as a needle.

Abstract: A closure device for connection to a fluid container which has an opening for receiving the device. The closure device has a base section which may sealably cover the container opening. The base section has a spike receiving opening passing there through with at least one air vent on the base section which is spaced from the spike receiving opening. A hydrophobic air filter, is associated with the air vent. Adjoining the base section is an internal cover, which lies over the aperture, covering it and the base section. The internal cover has a pierceable portion which is in alignment with the spike receiving opening of the base section.

Abstract: A cap assembly for use with a container having a stopper and a closure including a cap defining a chamber above a stopper. The cap on said closure, said cap including an access disc penetrable by a syringe position in alignment with the stopper for access to the container by the syringe. The assembly further including vent ports for communication between the chamber and the atmosphere. Finally there is a filter in the chamber for filtering gas flow through the vent port.

Abstract: According to the present invention, a vial cap is provided which has two openings, one for receiving the neck of a syringe and allowing medicine to flow into the syringe, and another for allowing air to flow into the vial as medicine is extracted. A safety lid to the vial cap is preferably provided for assuring sterility. A membrane may also be provided to cover the interior surface of the vial cap so that no medicine leaks into the region between the vial cap and its safety lid while the medicine is being transported and stored.The shape and size of the two openings may be varied according to the application, in particular according to the material used for the cap and the medicine being stored in the vial.

Abstract: A plastic disposable canister for use with a conventional paint spray gun. The canister is a cylinder having a closed bottom, an open top, and two diametrically opposed external stiffening ribs extending the height of the canister. The canister includes two diametrically opposed cover engaging members formed from the upper portions of the stiffening ribs for engagement with the most commonly available paint sprayers.

Abstract: A method of utilizing an apparatus of the type comprising a vial container hazardous material in the vial container in a condition requiring a diluent to be mixed therewith to form the liquid solution, and an assemblage carried by the vial container for providing (1) a sealed medicament chamber within the vial container within which the hazardous material is disposed, (2) a filter vented control chamber and (3) a sealed variable volume control chamber between the vented control chamber and the medicament chamber. The method is such as to enable an open end of a syringe needle of a diluent syringe having a syringe chamber containing diluent in communication therewith to be moved into and withdrawn successively from the chambers so as to mix the diluent with the hazardous material. The method also contemplates procedures for separately refilling a dosage syringe and for relieving any residual pressure in the vial chamber with the use of an empty syringe prior to initial or final refilling of a dosage syringe.

Abstract: A medicament vial safety cap which may be formed integrally at the time of manufacture of the medicament vial or added as an accessory to an existing conventional medicament vial allows an equalization of pressure to occur within a chamber adjacent to the stopper of the vial so that aerosolization of medicaments does not occur as a hypodermic needle is inserted or withdrawn from the vial. A hydrophobic filter, communicating between the vial safety chamber and the ambient, allows the pressure equalization to occur while trapping molecules of medicament inside the chamber.

Abstract: A dirt and bacteria tight connection between a container for chemicals and the suction pipe of a metering pump is disclosed, which may in particular be used for the treatment of drinking water. In this way it is achieved that only degerminated air may enter the interior of the container when sucking metering fluid from the container.

Abstract: A method of preparation of valves for a flat, flexible, sterilizable container capable of sterilely containing a liquid to be removed under absolutely sterile conditions which comprises the steps of:forming a two-layer laminate including a first layer of a copolymer of ethylene with a minor proportion of butylene and a second layer of an amide polymer; forming a pocket in the two-layer laminate wherein the first layer forms the inner surface of the pocket; providing an elastomeric core element having spaced major faces; inserting the core element into the pocket in the two-layer laminate; providing a three-layer laminate including a first outer layer of a major portion of a propylene polymer, a second outer layer of a copolymer of ethylene with a minor proportion of butylene, and an intermediate layer of an amide polymer; orienting the three-layer laminate so that the second outer layer thereof is apposed to the first layer of the two-layer laminate; expelling air surrounding the core element in the pocket; w

Abstract: A device for culturing microorganisms includes a vessel having a mouth for containing a culture medium and a stopper member for hermetically sealing the vessel. The stopper member is provided with a through hole on its peripheral wall for communicating with the inner atmosphere of said vessel.

Abstract: A sealed container especially adapted for medical usage to receive and dispense fluids without contamination has a two orifice closure system whereby contaminants are kept out by a microfilter when an inlet orifice is opened for additions, and by a valve when an outlet orifice is opened for withdrawals. The closure has an upper removable seal and a lower fixed seal spaced from the upper removable seal and cooperating therewith in defining an operative space compartment sealed from both the interior of the container and the outside. In some embodiments, the lower seal has inlet and outlet passageways joining the interior of the container with the operative space compartment. An independent seal accessible from the operative space compartment is provided for the inlet passageway which is associated with the microfilter for stopping ingress of contaminants into the container. The valve provided at the outlet passageway is accessible from the operative space compartment to control outflow.

Abstract: A method for aseptically sowing small seeds or spores of green plants includes preparation of a sterile closed flask (one-half pint jar) containing a growth medium and having both a contamination-resistant vent and a puncturable, resealing membrane in its closure. The seeds or spores are placed in a hypodermic syringe and a sterilizing solution is drawn into the syringe and held in contact with the seeds long enough to sterilize their surfaces. If desired, the sterilizing solution is ejected from the syringe through a filter or otherwise so as to retain the seeds or spores, and replaced by a wash liquid. The syringe is fitted with a sterile hypodermic needle of sufficient bore size to pass the seeds or spores. The needle is inserted through the membrane, after sterilizing the outside surface of the membrane, and the sterilized seeds or spores are discharged directly from the syringe onto the growth medium in the flask.

Abstract: According to the present invention, a vial cap is provided which has two openings, one for receiving the neck of a syringe and allowing medicine to flow into the syringe, and another for allowing air to flow into the vial as medicine is extracted. A safety lid to the vial cap is preferably provided for assuring sterility. A membrane may also be provided to cover the interior surface of the vial cap so that no medicine leaks into the region between the vial cap and its safety lid while the medicine is being transported and stored.The shape and size of the two openings may be varied according to the application, in particular according to the material used for the cap and the medicine being stored in the vial.

Abstract: A cap having a core structure dimensioned to receive a pipette therethrough. The cap includes two axially aligned frangible seals that are affixed to the core structure in a spaced-apart relationship. The frangible seals are constructed so that air passageways are formed between the frangible seals and a pipette tip when the pipette tip penetrates the frangible seals. The cap optionally includes a filter interposed between the first and second frangible seals.