Self-sealing, Piercable-type Closure Patents (Class 215/247)
  • Patent number: 11291777
    Abstract: A needle cannula for an injection device, extends along a central axis and comprises: a) a skin piercing distal end (133b), b) a proximal end (133a) configured for penetrating a seal structure (102b) of a medicament container (102), and c) a sidewall extending between the skin piercing distal end (133b) and the proximal end (133a), wherein the proximal end (133a) is defined by an angled surface (134) pointing proximally, the angled surface (134) defining a leading portion (134.1) and a heel portion (134.2), and wherein the angled surface (134) comprises a surface portion (134a, 134b) at the heel portion (134.2) forming an angle (?1) between 50 to 75 degrees with respect to the central axis, and further comprises a surface portion (134c) at the leading portion (134.1) forming an angle (?2) between 60 to 85 degrees with respect to the central axis. An injection needle assembly for an injection device and an injection device comprising such assembly are further described.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: April 5, 2022
    Assignee: Novo Nordisk A/S
    Inventors: Lene Westergaard Toennesen, Erik Pedersen, Ejnar Laustsen
  • Patent number: 11192701
    Abstract: A method is provided comprising loading shells into shell retention chambers of a shell management module, the shells including corresponding reservoirs configured to hold individual quantities of liquid, the shell retention chambers arranged in a predetermined pattern on a platform of the shell management module. The method further comprises orienting discharge ends of the shells along an actuation direction within the shell retention chambers, and covering the discharge ends with closure lids to seal bottoms of the corresponding reservoirs.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: December 7, 2021
    Assignee: ILLUMINA, INC.
    Inventors: Paul Crivelli, Gary Watts
  • Patent number: 11179725
    Abstract: A self-adhesive layered septum is disclosed. In one example, the septum includes a first outer layer including a thermoplastic elastomer such as a styrenic block copolymer, containing styrene ethylene butylene styrene (TPE-SEBS) capable of closing at least partially an aperture formed when a needle is inserted through the layer; an adhesive second layer for adhering the septum to a mouth area of a well or container to which the septum is attachable; and a thermoplastic third layer between the first and second layers, thermobonded to the first layer and providing better adherence for the adhesive layer. The first layer includes a recess and a vent, which reduce pressure differentials in use, but together with the third layer minimize evaporation through the septum.
    Type: Grant
    Filed: July 6, 2017
    Date of Patent: November 23, 2021
    Assignee: CYTIVA SWEDEN AB
    Inventors: Hakan Erik Roos, Stefan Sjolander, Per Kjellin, Bharath Subrahmanya
  • Patent number: 11117710
    Abstract: A present application relates to a valve assembly for use with a liquid container. The valve assembly includes a spout containing an opening to the liquid container, the spout being configured to form a liquid-tight seal with a housing. A sleeve extends through the housing toward the liquid container through the opening. A valve is secured to the housing and extending into the opening through the sleeve and forming a liquid-tight seal with the sleeve. The valve includes a body portion with a cutaway section and a leg fixed to the valve by a hinge, wherein the leg is configured to flex outwards against the sleeve upon insertion of a tube into the valve causing the cutaway section to open a flow channel to allow liquid to flow through the valve assembly.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: September 14, 2021
    Assignee: RAPAK, LLC
    Inventors: Paul N. Georgelos, Kosmas Kasimatis, Ronald E. Kieras, Matt Ruschmeier
  • Patent number: 11110128
    Abstract: The present invention relates to new plasma or new platelet-rich plasma preparations, new cell dissociation methods, new cell associations or compositions, a method of preparation thereof, a use thereof, devices for the preparation thereof and preparations containing such a platelet-rich plasma preparation and cell associations or compositions. Specifically, the invention provides plasma or platelet-rich plasma alone or in cell composition preparations for use in tissue regeneration and bone regeneration and pain reduction.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: September 7, 2021
    Assignee: RegenLab USA LLC
    Inventors: Antoine Turzi, Donald Du Toit
  • Patent number: 11096863
    Abstract: An object is to provide a port that is capable of securely preventing pulling-out of a sealing plug from a port body. Provided is a port including: a sealing plug through which a hollow needle can be pierced; a port body having a hollow structure with the sealing plug disposed therein; and a pulling-out preventing member to be attached to the port body. The port body includes: a part to be sealed that has a tubular shape with a first end and a second end opposite to the first end, and is configured so that the sealing plug is sealingly inserted into the part to be sealed; a connection part that has a tubular shape, is continuous with the first end of the part to be sealed, and has an outer periphery connected to the bag body to be filled with a medical liquid; and a part to be fitted that is formed in any one of an inner peripheral surface of the part to be sealed, an outer peripheral surface of the part to be sealed, and the second end of the part to be sealed.
    Type: Grant
    Filed: December 17, 2015
    Date of Patent: August 24, 2021
    Assignees: Otsuka Pharmaceutical Factory, Inc., Otsuka Techno Corporation
    Inventors: Yasuyuki Kajihara, Hidenari Shoji, Masamichi Okubata, Fumito Uesugi, Ryuta Kazumori
  • Patent number: 11077994
    Abstract: Embodiments of the present disclosure generally relate to caps, closures, seals, and containers, and control of flow of fluids. Certain embodiments can be used with fluids related to machinery, for instance, engine oil, brake fluid, coolant, transmission fluid, and power steering fluid. Certain embodiments of the present disclosure effectively hold and transfer a fluid or a fluid substance, further being able to open, close, and regulate fluid flow. Embodiments include a single piece tubular component that includes a cap interiorly attached to such tubular component with ribs, and a container having a tapered end. In certain embodiments, a tube is attached to the cap. In certain embodiments, a nozzle collar having a tapered end is adapted to attach to a container.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: August 3, 2021
    Inventors: Mathew Meyer, Yuta Okkotsu
  • Patent number: 11040808
    Abstract: A metal child resistant container with a screw lid that comprises a main body, an inner cap that screws on to the main body forming an air tight seal, and an outer cap that is located over the inner cap. The outer cap prevents the user from directly interacting with the inner cap and requires the user to apply pressure to the outer cap. The inner cap has indentions that match with similar indentions stamped in or attached to the outer cap. When pressure is applied to the outer cap the inner cap and outer cap mover as one allowing the container to the open and closed. The container is further sealed by a foil seal and a desiccant material.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: June 22, 2021
    Inventor: Nicholas Patrick Karll
  • Patent number: 11034487
    Abstract: Examples herein relate generally to reservoirs for use in water distribution systems within an appliance. The reservoir herein allows for the combination of various components prepared by separate manufacturing processes and for reducing waste of those manufacturing components. Specifically, the reservoir herein provides a stopper separable from and for use with a container and a cap.
    Type: Grant
    Filed: June 29, 2019
    Date of Patent: June 15, 2021
    Assignee: Mercury Plastics LLC
    Inventors: Scott Raymond Gardner, Earl Christian, Jr., Donald Currey, William Blue
  • Patent number: 11026498
    Abstract: A plurality of caps are provided each with a visual coding of color and/or indicia for use with different sizes of bottles at least in accordance with a height of the bottles from a closed bottom end to an open top end for engaging each of the caps. Each of the caps has a tube mounted to, or through, an aperture extending through a top closed end of the cap to extend a selected length enabling one end of the tube to reach or extend along an interior surface of the bottom end of any of the bottles of the height to which the cap is coded for use therewith. The other end of tube is extendable to a bioreactor container. Each of the caps has another tube or port to another aperture of the cap to provide an air vent with an optional air filtering device.
    Type: Grant
    Filed: May 27, 2020
    Date of Patent: June 8, 2021
    Assignee: ULTRAFAB, INC.
    Inventors: Alan P. Radcliffe, Alan J. Demello
  • Patent number: 10959756
    Abstract: Methods and devices are provided for various insufflation sealing approaches for a trocar. For example, a trocar is provided that has a housing and a cannula extending therefrom. The housing and the cannula have a tool pathway extending therethrough for receiving a surgical tool, and the housing has an insufflation port therein. A variety of seal elements are provided that seal the insufflation port to prevent fluid flow into the port. The port and seal elements are configured to have a reduced profile to prevent interference between the trocar and a tissue surface during use.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: March 30, 2021
    Assignee: Ethicon LLC
    Inventors: Katherine J. Schmid, Jeffery Kirk
  • Patent number: 10905631
    Abstract: A needleless syringe connector cap to be provided to a container having an aperture at its top, said cap comprising an elastically deformable plastic valve body. Said valve body comprises a first and second passage, each passage extending through the valve body. Both passages comprise a cross-slit valve in the extreme lower end of said passage, embodied as an aeration valve. The first passage is adapted to receive a first tapered syringe tip and the second passage is adapted to receive a second tapered syringe tip, wherein when fluid is withdrawn from a container to which the cap is provided through the first (second) passage using a first (second) tapered syringe tip to which said first (second) passage is adapted, the second (first) cross-slit valve opens in response to an under pressure in said container resulting from said withdrawal, so as to aerate said container.
    Type: Grant
    Filed: December 21, 2016
    Date of Patent: February 2, 2021
    Assignee: Scholle IPN IP BV
    Inventor: Jeroen Pieter Fiere
  • Patent number: 10857068
    Abstract: A fluid transfer connector or adapter for coupling to a container or pharmacy bottle for facilitating the transfer of fluid or medicine from the bottle to a syringe, or from the syringe to the bottle. Optionally, an additional connector can be provided for coupling the fluid transfer connector to the syringe.
    Type: Grant
    Filed: February 23, 2017
    Date of Patent: December 8, 2020
    Assignee: NeoMed, Inc.
    Inventors: Benjamin M. Davis, Mark M. Costello, Brian Ledwith
  • Patent number: 10772798
    Abstract: Liquid transfer devices with an integral telescopic vial adapter for use with an infusion liquid container and an initially non-punctured intact discrete injection vial. The integral telescopic vial adapter is configured for initial telescopic snap mounting on a discrete injection vial leaving its injection vial stopper non-punctured until a subsequent compaction for puncturing the injection vial stopper. The integral telescopic vial adapter includes a safety catch mechanism for precluding advertent compaction from a pre-compacted state to a compacted state. The integral telescopic vial adapter includes a clamping arrangement for irreversibly clamping same in its final compacted state.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: September 15, 2020
    Inventors: Amir Lev, Igor Denenburg, Uri David
  • Patent number: 10744500
    Abstract: Methods and systems disclosed herein provide systems and methods for maintaining sterile conditions inside of a biological-fluid container during an entire process of delivery, incubation, centrifugation, and extraction of fluid. The methods and systems also provide systems and methods for localized extraction of a portion of a biological fluid.
    Type: Grant
    Filed: December 29, 2017
    Date of Patent: August 18, 2020
    Assignee: ARTHREX, INC.
    Inventors: Hannah McIntyre, Christopher Bare, Melissa Tucker, Andrea Matuska
  • Patent number: 10597201
    Abstract: A retortable container is formed with an opening formed defined by a projecting rim. The rim includes an external surface and securing structure formed thereon. A flexible membrane is sealed to the rim and closes the opening. A closure is provided having a molded plastic tubular ring and a separately formed molded plastic disk. The tubular ring includes an overlapping flange at a top and directed inwardly towards an inwardly positioned open area. The skirt includes an engagement structure for securing the closure to the external surface of the rim. The disk is separately attached to the ring within the open area after the retort process is applied to the sealed bottle.
    Type: Grant
    Filed: February 3, 2019
    Date of Patent: March 24, 2020
    Assignee: SONOCO Development, Inc.
    Inventor: Trevor Price
  • Patent number: 10551400
    Abstract: Device for solid-phase microextraction and analysis of substances to be analyzed, in particular in a gas chromatograph, with at least one collector, which is made of sorbent and/or adsorbent material and is placed on a rod-like support, and with at least one sample container, which is sealed with a pierceable partition wall and into which the collector is introduced piercing the partition wall for a sampling time, wherein the sealing of the sample container is assembled from the pierceable partition wall and a clamping ring, which can be mounted on the sample container and presses the partition wall together with a sealing element onto an upper rim of the sample container, and which comprises a socket in which a fitting of a transport adapter which is attached to a handling end of the rod-like support can be anchored detachably and with sealing surface pressure after the collector is inserted into the sample container following piercing the partition wall.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: February 4, 2020
    Assignee: GERSTEL Systemtechnik GmbH & Co. KG
    Inventors: Ralf Bremer, Bernhard Rose
  • Patent number: 10537894
    Abstract: In one embodiment described herein, a cartridge is provided comprising a cartridge frame; a plurality of diluents each in an expandable container; a plurality of reagents each in an expandable container; and a plurality of mixing vessels comprising empty expandable containers.
    Type: Grant
    Filed: March 10, 2017
    Date of Patent: January 21, 2020
    Assignee: Theranos IP Company, LLC
    Inventors: Gary Frenzel, Samartha Anekal, Daniel Young
  • Patent number: 10526122
    Abstract: A beverage dispensing system for dispensing alcoholic beverages includes a beverage dispensing package and a connector assembly configured to be coupled to the package. The package includes an outer container and at least one divider positioned within the outer container to form a plurality of compartments. The package also includes a plurality of inner containers, with one of the inner containers positioned within each of the compartments. Each inner container stores an alcoholic beverage and each container includes an outlet to enable the alcoholic beverage to be dispensed. The connector assembly includes a plurality of connectors for coupling to a respective outlet of the inner containers, and a dispensing line coupled to the connectors. The connector assembly couples the inner containers in flow communication with the dispensing line to enable the alcoholic beverages within each of the inner containers to be jointly dispensed through the dispensing line.
    Type: Grant
    Filed: February 1, 2019
    Date of Patent: January 7, 2020
    Inventors: Peter DeRaedt, Bernd Witzany
  • Patent number: 10507664
    Abstract: The liquid cartridge for an industrial inkjet printer for printing goods has a film bag, a connector stub connected thereto, and a lower cap. The connector stub has an opening which is closed by the lower cap which has a lower rubber layer, a plastic layer formed by the connector stub, and a lower holder. The lower holder has a lower window which is situated above the opening. The lower holder is fastened to an outer side of the connector stub. The lower rubber layer and, underneath it, the plastic layer are situated below the lower window, and they are in contact with one another and with the lower holder.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: December 17, 2019
    Inventor: Andreas Slomianny
  • Patent number: 10450449
    Abstract: The invention relates to a polymer compound for a PVC-free sealing insert for twist crowns, wherein the Shore A hardness of the polymer compound is between 50 and 90 and in the compressive deformation test analogous to ASTM D395-97 Method B at 70 DEG. C. the polymer compound exhibits a compression set of 30-90%.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: October 22, 2019
    Assignee: Actega DS GmbH
    Inventors: Dany Mängel, Waldemar Eichler
  • Patent number: 10434436
    Abstract: Provided is a gas-blowing vaporizing and drying device, which includes: a sample tube in the form of a double tube including an inner tube for a solution and an outer tube for a gas, the inner tube protruding from one end of the outer tube by length L; and a collection container including a container body and a lid provided with a protrusion sleeve tube, the protrusion sleeve tube including a coupling portion at an end to be located outside the container body and a sleeve portion of a length equal to or longer than L having an open end to be located inside the container body, the coupling portion being designed to be coupled to the aforementioned one end of the outer tube in an air-tight manner.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: October 8, 2019
    Assignee: Shimadzu Co.
    Inventors: Tomoyuki Yamazaki, Przemyslaw Stasica, Bob Boughtflower
  • Patent number: 10414645
    Abstract: An insert is disclosed for use with a closed loop dispensing system. The insert is press-fitted into the throat of a liquid container. The insert includes a normally closed chemical valve which is opened when pierced by a vertically movable lance to permit the liquid in the container to be dispensed to a mixing machine or the like. The insert also includes a plurality of radially spaced-apart bi-directional valves which automatically permit air to be vented into the container. The bi-directional valves also permit off-gassing of gas in the container.
    Type: Grant
    Filed: February 5, 2019
    Date of Patent: September 17, 2019
    Inventor: Rodney Laible
  • Patent number: 10391245
    Abstract: A method for creating a sterile connection with a fluid in a container. The container has a sealing member sealing a first end of the container, and a barrier sealing a chamber in fluid communication with the sealing member. The method includes providing a valve sleeve assembly that includes a flexible sleeve having a barrier portion at an end of the flexible sleeve, a hollow first penetrator disposed within the flexible sleeve, and a hollow second penetrator at least partially disposed within the first penetrator. An interior of the flexible sleeve is sterile. The method also includes piercing the barrier portion and the barrier with the first penetrator, and displacing the second penetrator relative to the first penetrator and the sealing member to pierce the sealing member and establish the sterile connection with an interior of the container.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: August 27, 2019
    Assignee: Becton, Dickinson and Company
    Inventors: Richard Cronenberg, Abhijitsinh Raj, Matthieu Charvin, David Booth
  • Patent number: 10369800
    Abstract: A printing fluid container for a printing fluid source for a printer system, wherein the printing fluid container comprises a sealing material layer being arranged in a closure device printing fluid outlet opening, the sealing material layer having a fluid outlet condition, in which the sealing material layer is pierced by engagement of a fluidic interconnect device of the printing fluid source and the closure device printing fluid outlet opening, as well as a printing fluid source, a printer system, a printer system arrangement and a method of filling a printing fluid source.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: August 6, 2019
    Inventors: Garry Rooney, Frank Woods, Bryan Murphy
  • Patent number: 10273025
    Abstract: An apparatus and method for sterile filling comprises de-contaminating a needle penetrable surface of a device including a needle penetrable septum and a sealed chamber in fluid communication with the needle penetrable septum. A filling needle penetrates the needle penetrable septum, introduces substance through the filling needle and into the chamber and is, in turn, withdrawn from the septum. A liquid sealant is applied to the penetrated region of the septum. Radiation or energy is applied to the liquid sealant to cure the liquid sealant from a liquid phase to a solid phase.
    Type: Grant
    Filed: March 3, 2015
    Date of Patent: April 30, 2019
    Assignee: DR. PY INSTITUTE LLC
    Inventor: Daniel Py
  • Patent number: 10246232
    Abstract: A system includes a cap having an opening, and a septum configured to engage with the cap. The septum includes a first portion having a first width, and a second portion having a second width smaller than the first width. The second portion is sized and shaped to be received by the opening of the cap.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: April 2, 2019
    Inventors: Scott Richard Johnson, Daniel Salvatore Montuori
  • Patent number: 10239667
    Abstract: A retortable container is formed with an opening formed defined by a projecting rim. The rim includes an external surface and securing structure formed thereon. A flexible membrane is sealed to the rim and closes the opening. A closure is provided having a molded plastic tubular ring and a separately formed molded plastic disk. The tubular ring includes an overlapping flange at a top and directed inwardly towards an inwardly positioned open area. The skirt includes an engagement structure for securing the closure to the external surface of the rim. The disk is separately attached to the ring within the open area after the retort process is applied to the sealed bottle.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: March 26, 2019
    Assignee: Sonoco Development, Inc.
    Inventor: Trevor Price
  • Patent number: 10228310
    Abstract: A flow through fluid sampling system includes a sample tube and a cap. The sample tube is configured to collect a sample of a fluid and has an open top. The cap is configured to be secured to the sample tube to close the open top. The cap includes an inflow port configured to allow fluid to enter the fluid sample tube, an outflow port configured to allow fluid to leave the sample tube.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: March 12, 2019
    Assignee: Haemonetics Corporation
    Inventors: Michael Ragusa, Matthew J. Murphy
  • Patent number: 10219983
    Abstract: A cap system for sealing injectable drugs within a vial is disclosed. The system includes an elastomeric stopper, a retainer member, a locking member, a cap assembly and a piercing member. The retainer member is arranged to snap onto the vial and the locking member slid with respect to the retainer member to permanently seal the vial. The cap assembly includes a cap and a band and is coupled to the locking member. The cap releasably holds the piercing member. The band is arranged to be removed to enable the cap to move the piercing member to penetrate the stopper, whereupon the cap can be removed. The piercing member is arranged to be connected to a syringe or other instrument to withdraw the vial's contents.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: March 5, 2019
    Assignee: Genesis Packaging Technologies
    Inventor: Peter Zelinski
  • Patent number: 10207845
    Abstract: A closure with a self-resealing elastomeric septum has a shutter slidable between a closed position over the septum and an open position for exposing the septum. The shutter is spring biased towards the closed position, and may be pushed and held away from the closed position with the tip of an oral syringe to gain access for penetration of the elastomeric septum. The closure may have an upper portion mounted to a lower portion fastened for closing a container. A conduit extends through the upper and lower portions to the interior of the container. A break-away connection is adapted to preferentially break or separate when a sufficient bending or twisting force is applied to the upper portion relative to the lower portion. The conduit may be normally closed by a self-resealing elastomeric septum provided in the lower portion and a slidable shutter may be provided on the upper portion.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: February 19, 2019
    Inventor: Natalie Levy Sarraf
  • Patent number: 10195000
    Abstract: A cleaning device for a medical implement such as a female Luer connector. The cleaning device includes a cap having an interior cavity and an opening adapted to receive a site of the medical implement. The interior cavity is defined by an interior wall that includes a male Luer protrusion extending in the direction of the opening from an end of the interior cavity opposite the opening. A skin of cleaning material overlies at least a portion of the interior wall. The cleaning material may be pre-loaded with a cleaning agent and is adapted to clean the site of the medical implement.
    Type: Grant
    Filed: February 8, 2017
    Date of Patent: February 5, 2019
    Assignee: 3M Innovative Properties Company
    Inventors: Bobby E. Rogers, Gino Kang
  • Patent number: 10195112
    Abstract: An adaptor for coupling with a medical container filled with a number N of doses of a product including a gripping member for securing the adaptor to the medical container. The gripping member has at least one needle access port intended to face the outer surface of the septum of the medical container. The adaptor also includes a marking-device coupled to the needle access port, for designating to a user a not yet pierced area of said outer surface, for completing the next of the N successive piercings.
    Type: Grant
    Filed: November 25, 2013
    Date of Patent: February 5, 2019
    Assignee: Becton Dickinson France
    Inventors: Frederic Perot, Adrien Plouvier, Anick Lagier
  • Patent number: 10183786
    Abstract: The disclosure relates to a cylindrical closure for a product-retaining container constructed for being inserted and securely retained in a portal-forming neck of said container, said closure comprising at least one thermoplastic polymer and at least one natural organic filler wherein the lateral surface of said closure has a hardness of 40 to 90 Shore A. Such closures are particularly suitable for sealingly closing wine bottles.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: January 22, 2019
    Inventors: Olav Marcus Aagaard, Mohammad Reza Sadeghi, Malcolm Joseph Thompson
  • Patent number: 10159981
    Abstract: A plastic body including a generally cylindrical upper portion having an open end configured for engagement with an automated pipettor. The plastic body further includes a plurality of longitudinally oriented ribs disposed on an inner surface of the open end of the upper portion and a plurality of concave recesses disposed on an outer surface of the upper portion. Each of the recesses is disposed directly opposite an associated one of the ribs, and each of the recesses extends along at least part of the length of the associated rib.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: December 25, 2018
    Inventor: Byron J. Knight
  • Patent number: 10160576
    Abstract: A closure (2) for closing an opening of a container (1) for storing and removing sterile or moisture-sensitive media has a closure cap (3), which can be connected to the container in a fluid-tight manner, and a piercable, self-closing septum (20), which closes at least one removal opening (7) in the closure cap (3) in a fluid-tight manner, wherein the closure (2) has a rotatably mounted protective cap (4) with a cutout (5). The cutout (5) is arranged off-centre in the protective cap (4) and the closure cap (3) has off centre a closure region (9) which is not impinged by the at least one removal opening (7) and is larger than the cutout (5) in the protective cap (4). The closure (2) has a latching mechanism, which is suitable for arranging the protective cap (4) in relation to the closure cap (3) in such a way that the cutout (5) in the protective cap (4) is aligned either in line with the or a removal opening (7) in the closure cap (3) or at a distance from the removal opening or openings (7).
    Type: Grant
    Filed: June 2, 2008
    Date of Patent: December 25, 2018
    Inventors: Lothar Grunert, Andreas Mrass, Peter Mueller, Kemal Eray, Thorsten Hassenzahl, Klaus Oswald
  • Patent number: 10155076
    Abstract: A method for treating dialysate solutions used in dialysis wherein dialysate is treated in an early part of a dialysis treatment session by external infusion of bicarbonate solution into the dialysate circuit to eliminate the need for bicarbonate requirements in concentrates used for preparation of precursor dialysate (priming) solutions and/or for a solid bicarbonate layer in a sorbent cartridge. Dialysate is treated in a latter part of a dialysis treatment session by introduction of sterile dilution water to reduce sodium concentration in the dialysate. The method provides a more efficient and reduced use of dialysate fluids, electrolytes, sorbent cartridge materials, equipment scale, or any combinations of these, while maintaining purity standards and applicable physiological ranges for bicarbonate, sodium, and other dialysate solution components over the course of a dialysis treatment session.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: December 18, 2018
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventor: Stephen Merchant
  • Patent number: 10150605
    Abstract: A chemical storage container enables easy installation of a chemical nozzle and a pressurized gas supply nozzle. The chemical storage container includes a metal can having a top opening, a chemical storage bag disposed in the metal can and an ejection member mounted to the chemical storage bag. The top opening of the metal can is closed by a lid to which a chemical nozzle and a pressurized gas supply nozzle are mounted. The chemical nozzle penetrates through the ejection member. A pressurized gas from the pressurized gas supply nozzle is supplied through the ejection member into a pressurization space formed between the metal can and the chemical storage bag.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: December 11, 2018
    Inventors: Katsuyuki Motai, Masato Miyake
  • Patent number: 10143796
    Abstract: A therapeutic fluid delivery system including, in various examples, a first reservoir configured to house a first therapeutic fluid, a second reservoir configured to house a second therapeutic fluid, and an inlet port configured to receive a fluid delivery needle is described. The inlet port is configured for fluid communication between the fluid delivery needle and the first reservoir, and the inlet port is further configured for fluid communication between the fluid delivery needle and the second reservoir.
    Type: Grant
    Filed: August 25, 2011
    Date of Patent: December 4, 2018
    Assignee: Medtronic, Inc.
    Inventor: James M. Haase
  • Patent number: 10131472
    Abstract: Provided is a vial rubber stopper using multiple types of rubber to prevent the vial rubber stopper from being scraped and from sticking to a presser plate. The vial rubber stopper includes: a cap portion having a flange; a piercing area formed to have a recess at a top surface of the cap portion and configured to traverse longitudinally the cap portion in an axial direction from the recess to a bottom surface of the cap portion; and a leg portion formed on the bottom surface of the cap portion in a way of extending downward and located outside the piercing area with respect to an axial center of the cap portion. The piercing area is formed of rubber having rubber hardness from 20 to 35, and the top surface other than the recess of the cap portion is formed of rubber having rubber hardness from 58 to 90.
    Type: Grant
    Filed: December 28, 2010
    Date of Patent: November 20, 2018
    Inventors: Takashi Asai, Tadatoshi Uchida, Masanobu Iwasa, Ryouji Komatsu
  • Patent number: 10099821
    Abstract: A medical rubber closure according to the present invention includes a disc-shaped flange portion and a leg portion formed to be continuous to a lower surface side of the flange portion, and a region at the lower surface side of the flange portion and the leg portion are made of a nitrile based rubber, a region at a top surface side of the flange portion is made of a butyl based rubber, and the leg portion is laminated with a coating layer made of a fluorine based resin film.
    Type: Grant
    Filed: September 15, 2015
    Date of Patent: October 16, 2018
    Inventors: Yoshikazu Masuyama, Katsushi Maeda
  • Patent number: 10099823
    Abstract: There is provided a vial cap with which, when there is a possibility that a cover which covers a stopper for a vial has come off and the stopper for the vial has been contaminated at a stage prior to use, the fact can easily be recognized. The vial cap is a resin vial cap (1) to be attached to a mouth portion (72) of a vial (70) to fix a stopper (74) fitted into the mouth portion (72) so that the stopper may not come off the mouth portion (72). The vial cap (1) is provided with a cap main body (8) that has an upper opening (6) formed therein and a cover (40) that covers the upper opening (6) of the cap main body (8). The cap main body (8) has a plurality of pin-receiving holes (10) formed therein, and the cover (40) has a plurality of fixing pins (46). Each pin-receiving hole (10) and a fixing pin (46) that is paired with the pin-receiving hole (10) are formed in complementary shapes.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: October 16, 2018
    Assignee: DAIKYO SEIKO, LTD.
    Inventor: Hideaki Kawamura
  • Patent number: 10046323
    Abstract: The application relates to a closing element for closing a container for samples for analysis, particularly biological samples. The application also relates to an assembly of a container and a closing element connected to the container. The application also relates to a device and method for analyzing samples. The closure comprises a vent channel (6) with a bacterial filter (7), a penetrable element (5) and the vent channel is configured to be connected with an analyzer and can be opened and closed.
    Type: Grant
    Filed: May 1, 2013
    Date of Patent: August 14, 2018
    Assignee: eNose Holding B.V.
    Inventor: Albert Bos
  • Patent number: 9999888
    Abstract: A specimen container for urine and other liquids is provided having a container lid, an elastomeric septum, a cup, and a non-porous seal. The elastomeric septum covers a septum hole in the lid, and the non-porous seal is affixed to the lid such that it creates a liquid-tight boundary between the septum and the chamber within the bottle. The septum includes a depressed portion and an area of minimum thickness shaped to allow an implement to pass through the area of minimum thickness. The depressed portion may also include a pre-cut which allows the implement to pass through the septum more easily.
    Type: Grant
    Filed: May 19, 2016
    Date of Patent: June 19, 2018
    Inventors: Robert Ziegler, Alex Stefanowicz
  • Patent number: 9987420
    Abstract: Systems and methods for a fluid reservoir for use with a fluid infusion device which is automatically filled are provided. A set connector for use with a fluid reservoir of a fluid infusion device includes a body for defining a fluid flow path out of the fluid reservoir. The body includes at least one locking tab that cooperates with a portion of the fluid infusion device to removably couple the body to a proximal end of the fluid reservoir. The body is movable between a first position, in which the fluid flow path is obstructed, and a second position, in which the fluid flow path is open.
    Type: Grant
    Filed: November 26, 2014
    Date of Patent: June 5, 2018
    Inventor: Jacob E. Pananen
  • Patent number: 9956138
    Abstract: A protective cap (1) for application on a medical device such as a medical vial (2) comprising a membrane holder (3) in which a resilient membrane (18) is mounted. The protective cap (1) is provided with connection means (10) for connecting the cap (1) to the medical device (2). The resilient membrane (18) comprises a piercing portion (20) and a sealing portion (22) and is mechanically and/or adhesively held in the protective cap (1) and is arranged to be brought into sealing contact with a receiving portion of the medical device (2) when the protective cap (1) is applied on the medical device (2).
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: May 1, 2018
    Assignee: Carmel Pharma AB
    Inventor: Gunnar Ohlin
  • Patent number: 9925120
    Abstract: A cap for use in enteral feeding from a container. The cap includes a base and an insert cutter. The base has a top surface, a bottom surface, and an outer ring. The top surface has a protruding port suitable for insertion of a spike connector. The protruding port defines a spike insertion chamber extending from a spike connector insert aperture to a spike connector outlet aperture. The outer ring is configured for attachment to a container having a mouth. The insert cutter has a first end portion attached to the bottom surface of the base and about an edge of the spike connector outlet aperture and a second end portion extending over at least a portion of the spike connector outlet aperture. The insert cutter is capable of flexing in an insertion direction of a spike connector inserted through the spike insertion chamber.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: March 27, 2018
    Inventors: John Kropczynski, Jeremy McBroom, Meghan Linden
  • Patent number: 9918902
    Abstract: A bottle for containing pharmacological and/or nutritional active substances is described. The bottle comprises a closing cap pierceable by the pressure exerted with the luer of a needle-free syringe. The closing cap is made as a single piece including a check valve and closing lips which can be opened by introducing a syringe luer and can be elastically closed back upon the extraction of the luer introduced, and a membrane which is pierceable and elastically resealable to hermetically close the inlet end of the check valve.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: March 20, 2018
    Inventor: Paolo Giuseppe Gobbi Frattini
  • Patent number: 9908666
    Abstract: A bottle neck insert can include a cylindrical body having a first end and a second end, the cylindrical body having a plurality of rings; a flange provided at the first end, the flange protruding outwardly from the cylindrical body in a radial direction of the cylindrical body; and a valve section at the second end, the valve section having at least one slit, wherein the flange is configured to seat the insert onto a neck of a bottle and the valve section is configured to allow a pipette to pass through. A bottle storage system, can include a bottle having a neck with a smooth interior surface; an insert that is configured to fit inside the neck of the bottle; and a pipette assembly that is configured to proceed through the insert into the bottle.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: March 6, 2018
    Assignee: Purebacco USA LLC
    Inventors: Mark D. Walsh, Bruce C. Nemec, Jason R. Rohr
  • Patent number: 9877706
    Abstract: A biopsy device includes a probe, a holster, and a tissue sample holder for collecting tissue samples. The probe includes a needle and a hollow cutter. The tissue sample holder includes a housing having a plurality of chambers that are configured to receive a plurality of strips connected by at least one flexible member. The flexible member is configured to permit the strips to pivot relative to each other such that the strips can shift between a flat configuration and a arcuate configuration. The tissue sample holder is rotatable to successively index each chamber to the cutter lumen such that tissue samples may be collected in the strips. The strips may be removed from the tissue sample holder and placed in a tissue sample holder container for imaging of tissue samples.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: January 30, 2018
    Assignee: Devicor Medical Products, Inc.
    Inventors: Trevor W. V. Speeg, Edward A. Rhad, Emmanuel V. Tanghal, Morgan R. Hunter, Jessica P. Leimbach, Andrew P. Nock, Kevin M. Fiebig