Abstract: A closure comprises a cylindrical element (1, 101) having a first portion (2, 102) and a second portion (3, 103), the latter being adapted to engage, as a removable cap, in a portion of a neck (5) of a container, an overcap (8, 108) attached to the cylindrical element (1, 101), comprising a first body (9, 109, 209) and a second body (15, 115, 215), attached together and defining a seat (19, 219). The cylindrical element (1, 101) is partially disposed in the seat (19, 219) to be locked within the seat (19, 219).

Abstract: This invention relates to a compound of the Formula I X—C(O)—Y—G—R  I (wherein X, Y, G and R have the values defined in the description), or a pharmaceutically acceptable salt thereof, processes and intermediates for the preparation of such a compound or salt, pharmaceutical compositions comprising such a compound or salt and methods of their use as thrombin inhibitors, coagulation inhibitors and agents for the treatment of thromboembolic disorders.

Abstract: A stopper assembly for pharmaceutical containers or the like having a pull ring operable between a position flush with the top face of the stopper and an erect position engageable by the finger of the user for removing the stopper from the container. In acccordance with the preferred embodiment, the stopper and pull ring member are separate elements. The stopper which is preferably made of rubber has an annular groove with a locking shoulder to receive an insert ring of the pull ring member of complemetary shape to retain the two in a locked position. A pull ring is connected to a flange of the insert ring by a flexible hinge. The pull ring normally lies in the plane of the insert ring flange flush with the top face of the stopper and may be easily raised to an erect position to receive a finger of the user to enable removal of the stopper from a container by a pulling action.