Abstract: A dispensing tip apparatus for an eye drop dispenser to administer topical ophthalmic solutions is described. The apparatus integrates an ophthalmic solution-dispensing tip with an optical gauging assembly. The tip provides continuous visual feedback about it orientation and relationship to the eye. The dispensing tip when attached to any standard topical ophthalmic solution dispensing bottle or reservoir enables the user to view a target, visually align the dispenser tip, and administer an eye drop with precision. There is also a visual feedback by which the dispenser tip is prevented from gaining too close proximity and contacting the eye, thus preventing contamination of the medication and its dispenser. The visual feedback can also contain textual or graphic information that serves as a promotional advertisement. The is assembly can be attached to the neck of an eye drop bottle or attached to the tip of an eye drop bottle.

Abstract: A bottle for the creation, storage, administration and dispensing of elemental iodine is disclosed. An amount of crystal iodine is safely housed at the bottom of the bottle. Water is poured into the bottle and contacts with the crystal iodine to form elemental iodine. With the crystal iodine safely secured at the bottom of the housing, the formed elemental iodine maintains contact with the crystal iodine to maintain its stability and extends is shelf life. Several dispensing device are also disclosed for dispensing or administering the elemental iodine, as needed, in order to treat internal and external areas of a human's or animal's body.

Abstract: A viscous material noncontact jetting system has a jetting dispenser mounted for relative motion with respect to a surface. A control is operable to cause the jetting dispenser to jet a viscous material droplet that is applied to the surface as a viscous material dot. A device, such as a camera or weigh scale, is connected to the control and provides a feedback signal representing a size-related physical characteristic of the dot applied to the surface. The size-related physical characteristics of subsequently applied dots is controlled by heating and cooling, or adjusting a piston stroke in the jetting dispenser, in response to the size-related physical characteristic feedback. Dispensed material volume control and velocity offset compensation are also provided.

Abstract: An arrangement for a dropper, in particular a container (bottle) (1) made of injection-molded plastics, preferably, but not necessarily, translucent, with a base (2) having the form of a membrane (M), having a different thickness than the container, but being an integral part of the container (bottle) (1), with a corrugated perimeter (3) that causes the membrane (M) to act like a spring, making it considerably easier to actuate and move the liquid mechanically towards the dose dispensing device (4).

Abstract: The present invention provides a device to facilitate the self-administration of eye drops. The device includes a body portion adapted for placement on the user's face, generally over the eye in which the drops are to be applied. The body portion preferably includes an integral handle which may be held between the thumb and forefinger of the user. Many embodiments may also incorporate a nose bridge to assist in locating the device in the correct position.

Abstract: A liquid dispensing apparatus for dispensing droplets of a liquid, and methods for measuring various fluid parameters of the liquid are described. The liquid dispensing apparatus comprises a container having a chamber for holding a liquid. An orifice is positioned at an end of the chamber for dispensing droplets of the liquid, the orifice being configured to retain the liquid in the container if the container is positioned with the orifice facing in a downward direction. An acoustic transducer means is at least partially positioned in the chamber for periodically propagating a focused acoustic beam toward the orifice and through at least some of the liquid while the liquid is contained in the chamber, with the focused acoustic beam being capable of causing a droplet of the liquid to be ejected from the orifice when a free surface of the liquid is within the depth of field of the acoustic transducer means.

Abstract: Polymers having the formula R(LE)X wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and x endgroups, E is an endgroup that is covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain having at least 5 identical repeat units that is capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE)X in the polymer may be the same as or different from one another. Monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer, may be designed. Use of the polymer to fabricate a configured article from the surface-modified polymer or to fabricate a coating or topical treatment on an article made from another material.

Abstract: A method and device for periodically perturbing the flow field within a microfluidic device to provide regular droplet formation at high speed.

Abstract: A bottle for the creation, storage, administration and dispensing of elemental iodine is disclosed. An amount of crystal iodine is safely housed at the bottom of the bottle. Water is poured into the bottle and contacts with the crystal iodine to form elemental iodine. With the crystal iodine safely secured at the bottom of the housing, the formed elemental iodine maintains contact with the crystal iodine to maintain its stability and extends is shelf life. Several dispensing device are also disclosed for dispensing or administering the elemental iodine, as needed, in order to treat internal and external areas of a human's or animal's body.

Abstract: A dispensing container according to the invention includes a container body having a rod-like shape, The dispensing container is therefore compact and the user can hold the dispensing container as if the user holds a pen and use the thumb, the index finger, and any other finger to apply pressure to the dispensing container so as to dispense a drug solution. A heat insulating grip is attached to the outer circumferential surface of the container body, whereby heat originating from the body temperature of a finger of the user will not be transferred to the drug solution or volatilize it. No excessive dispensing that is not intended by the user will therefore occur. Since the container body is thin and hence unlikely crashed, the user can make adjustment of the pressure applied by the thumb, the index finger, and any other finger to readily extract a single droplet.

Abstract: A container especially adapted for dispensing food coloring includes a body including a neck with a nozzle including a skirt inserted into the body neck. The body neck and nozzle skirt together may have a plurality of beads to form an air and liquid (especially food coloring) tight seal. The nozzle includes a channel formed by substantially parallel walls including an orifice opening into the bottle at a first end of the channel, the orifice including a diameter of between 0.010 and 0.016 inches. The second end of the channel terminates in a flat nozzle tip for dispensing food coloring. The container provides an easy to use mess free dispenser with precise drop control and consistent drop size.

Abstract: Metered dose applicators that irradiate a portion of light sensitive product. When a dropper applicator is secured to a reservoir, a usable volume inside the dropper is reduced. As the dropper is removed from the reservoir, the usable volume in the dropper increases, creating a suction within the dropper that draws product into the dropper from the reservoir. When the dropper is off the reservoir, then a button that is accessible to a user is used to increase and decrease the size of the usable volume. The button also turns on a light that is effective to activate the product as it is being dispensed from the dropper.

Abstract: The present invention provides droplet actuators, modified fluids and methods relating to droplet operations. An aspect includes a droplet actuator including a droplet operations substrate; an oil based filler fluid on the droplet operations substrate comprising an oil soluble additive in the filler fluid; and a droplet in contact with the oil based filler fluid. Still other aspects are provided.

Abstract: A pressurized dispenser for dispensing sterile liquids in droplets having a flexible nozzle with flexible dispensing tip is provided. The tip has an opening which is normally sealed around a central plug. The dispenser is inverted and by pressing the side of the flexible nozzle a valve releases pressurized liquid into the space between the central plug and the dispensing tip which causes the tip to expand and release droplets.

Abstract: The invention concerns a container for packaging a liquid (1) to be dispensed in drops. The container is reversibly deformable by air input and is equipped with a head (3) for dispensing liquid through a nozzle (5). The dispensing head (3) comprises a recessed body (4) which is nested inside a neck (10) of the container and which holds a hydrophobic microporous pad (8) arranged upstream of a chamber (9). Chamber (9) is provided with an air reservoir for preventing the liquid from passing through the microporous pad (8) between two liquid dispensing operations, when the nozzle (5) is sealingly obstructed with a cap (6), and for drying a partly hydrophilic and hydrophobic filtering membrane (7) arranged in the dispensing head (3).

Abstract: A filter-equipped container which, particularly in a small-sized eyedrop bottle or the like, is capable of accurate dropping while preventing bubbles from being involved when a contents liquid is to be delivered through a delivery port. To solve such problem, a plug body 12 disposed in the mouth of a bottle 10 is provided with a delivery passage for delivering contents liquid received in the bottle 10, the delivery passage being provided with a filter 25. The filter 25 is composed of a filter film 25a for filtering bacteria to prevent the latter from permeating from upstream to downstream as seen in the direction of delivery, and a contents liquid holding member 25b of porous material that has microscopic pores, disposed upstream of the filter film 25a, the contents liquid holding member 25b being in planar contact with the filter film 25a.

Abstract: Various embodiments described in the application relate to an apparatus, system, and method for generating, within a conduit, discrete volumes of one or more fluids that are immiscible with a second fluid. The discrete volumes can be used for biochemical or molecular biology procedures involving small volumes, for example, microliter-sized volumes, nanoliter-sized volumes, or smaller. The system can comprise an apparatus comprising at least one conduit operatively connected to one or more pumps for providing discrete volumes separated from one another by a fluid that is immiscible with the fluid(s) of the discrete volumes, for example, aqueous immiscible-fluid-discrete volumes separated by an oil.

Abstract: The present invention relates to a bottle for packaging a liquid to be distributed drop by drop comprising a reservoir the walls of which can be reversibly elastically deformed by letting air into the container, surmounted by a liquid dispensing head comprising a dropper nozzle protruding from the bottle and an anti-bacterial filter membrane, that is partially hydrophilic and partially hydrophobic, interposed across the path of the liquid and the air, at the base of the said nozzle. In the dispensing head, the proposal is to create the nozzle by itself out of a material containing a bactericidal agent that has the effect of preventing any bacterial growth on the surface of the said nozzle on the outside of the antibacterial membrane. A porous core is advantageously positioned inside the duct through which liquid is expelled and air is admitted.

Abstract: Disclosed herein is a hand-operated dropper configured to suction and discharge a predetermined amount of liquid type content upon pressing an elastic button, the hand-operated dropper including a housing, forming an external appearance of the dropper, for containing content, a housing cap for hermetically sealing an internal space of the housing from the outside, a tube coupled to an elastic button for suctioning content from the housing, the elastic button hermetically coupled to the upper end of the tube, the elastic button being also coupled to the housing cap, and a closure coupled to the housing cap while surrounding the outside of the elastic button in such a manner that opposite sides of the elastic button are exposed to the outside for suctioning a predetermined amount of content while protecting the elastic button from external force.

Abstract: A device for dosage of substances having a substance intake portion, which included at least one substance compartment for the intake of substance to be dosed, an emptying portion for the emptying the substance compartment and a weighing balance for the determination of the quantity of dosed substance, wherein the substance intake portion includes a plurality of substance compartments, which are able to be individually emptied. The device further includes a control means, which control the emptying of the substance compartments in a manner dependent on the quantity of dosed substance, which is determined by means of the weighing balance.

Abstract: Various embodiments of the present invention are directed to droppers that can be used at nighttime or in low-light conditions.

Abstract: The present invention relates to a high energy density beam welding system using molten metal droplet jetting. The present invention includes a beam emitting unit for emitting a high energy density beam onto a welded portion on a target object; and a molten metal droplet jetting unit for generating molten metal droplets to transfer or spray the molten metal droplets onto the welded portion on the target object, which follows a path of the beam emitting unit. Thus, it has advantages of widening a range of applications and enhancing the productivity and the quality in that a welding can be performed at a high junction efficiency even where a gap is wide, a loss in the high density energy beam is small, and heat distortions of the welded portion can be minimized.

Abstract: A device for expelling drops of a flowable product. The invention relates to a device for expelling drops of a flowable product, comprising a rotating outer drum and a feed channel for the product to be expelled extending into the outer drum, wherein the outer drum comprises passage openings on the circumference thereof, through which the product to be expelled runs from the feed channel and then exits in droplet shape. According to the invention, at least one outer circumference of the outer drum is provided with a coating that reduces wetting with the product to be tabletted compared to a base material of the outer drum. For example, the invention can be used for tabletting flowable products.

Abstract: It is intended to provide an object-holding sheet and an object-treating equipment, which are useful for arranging objects such as biological materials (e.g., cells, embryos or individuals) or particles having the similar size thereto and efficiently conducting procedures such as analysis and fractionation on the objects. The present invention provides an object-holding sheet for holding two or more objects, the object-holding sheet including: a sheet member having two or more through-holes; and an anti-drop member corresponding to each of the holes, wherein the holes have a size that enables only one of the objects to be held, and the anti-drop member is disposed in the vicinity of one opening of each of the holes so as not to permit the object held in each of the holes to pass through the opening.

Abstract: [Object] To provide a liquid material discharge device and method capable of causing a liquid droplet to be satisfactorily discharged to fly out even under a condition where discharge of a small amount of liquid material is required.

Abstract: Micro droplets are accurately placed in a reaction well. The reaction well (5) is formed in one surface of a well base (3). A channel base (11) is placed on the well base (3). The channel base (11) has, in its surface joined to the well base (3), a liquid introduction channel (12a) and a reaction well air vent channel (18a). The channel base (11) also has a recess (27) formed opposite to the reaction well (5) and recessed upward from the upper surface of the liquid introduction channel (12a). When viewed from above, a shoulder part (26) of the recess (27) is placed near the connection part between the reaction well (5) and the liquid introduction channel (12a) and is closer to the center of the reaction well (5) than a shoulder part (16) of the reaction well (5).

Abstract: Various embodiments of the present invention are directed to droppers that can be used at nighttime or in low-light conditions.

Abstract: A liquid storage container (eyedrops container) comprises a container body having a liquid storage portion for containing medical liquid therein, and an instilling portion for allowing the medical liquid to flow out in an opened stage. An aerating device having a filter element and a check valve for allowing ambient air to flow in from outside and preventing the liquid from flowing out to the outside is installed at the bottom of the container body. Further, a cap having an opening member and a valve member is mountable on the container body.

Abstract: A delivery system includes a material delivery system, wherein the delivery system is adapted to dispense a flowable material. Also included is a cover adapted to at least partially cover the material delivery system, and a messaging system adapted to play a message upon activation thereof.

Abstract: A discrete drop dispensing device comprises a substrate comprising an upper surface and a lower surface and orifices extending from the upper surface to the lower surface, adapted to receive a fluid at a flow rate. The discrete drop dispensing device also comprises an oscillator disposed adjacent to the substrate and configured to vibrate the substrate to expel drops having a substantially equal volume of the fluid. The flow rate is substantially identical to a drop dispensing rate. A method and a device for performing liquid chromatography are also described. The method comprises automatically adjusting the drop dispensing rate to a change in the flow rate or a change in a composition of a mobile phase of the fluid.

Abstract: A bottle for the creation, storage, administration and dispensing of elemental iodine is disclosed. An amount of crystal iodine is safely housed at the bottom of the bottle. Water is poured into the bottle and contacts with the crystal iodine to form elemental iodine. With the crystal iodine safely secured at the bottom of the housing, the formed elemental iodine maintains contact with the crystal iodine to maintain its stability and extends is shelf life. Several dispensing device are also disclosed for dispensing or administering the elemental iodine, as needed, in order to treat internal and external areas of a human's or animal's body.

Abstract: A tip arrangement for a bottle used for dispensing viscous liquid, such as drops of medicine, is provided. Embodiments include a tip insert having an insert body and a piercing point at a lower end of the insert body, for piercing a top surface of the bottle and for retaining the tip insert on the top surface of the bottle after piercing. A passage extends from a distal end of the piercing point, through the insert body, to an opposing upper surface of the insert body. A dispensing tip at the insert body upper surface communicates with the passage for precisely forming drops of the liquid from the bottle.

Abstract: The invention relates to a dispensing device for dispensing liquid media having a housing (11), an outlet opening (14) for the medium, a medium reservoir (8) for storage of the medium and a conveying device (30) for transporting the medium from the medium reservoir (8) to the outlet opening (14), wherein a flow brake (40) is provided in a medium duct (16, 18) between the conveying device (30) and the outlet opening (14). In accordance with the invention, the flow brake (40) has a first flow brake component (60) which can be arranged and fixed relative to the housing (11) or to a second flow brake component (50) during assembly in several differing relative positions, wherein differing flow resistances of the flow brake (40) are achieved depending on the selected relative positions. Use in particular for eye drop dispensing devices.

Abstract: A drop dispenser has a substantially conical sleeve member with a narrow upper end and a wide lower end. Centrally located at the apex of the upper end of the sleeve member is an aperture which has an inner diameter and is circumscribed by a raised ridge. The aperture and the ridge form a nozzle. The interior space of the substantially conical sleeve member forms a substantially conical chamber between the narrow upper end and wide lower end of the sleeve member. The nozzle is in liquid communication with the chamber through the aperture. The drop dispenser may have external threads at the lower end of the sleeve member for engaging a cap having a protuberance centrally located at its internal top end for hermetically engaging the aperture of the nozzle when the cap fully engages the sleeve member.

Abstract: A bottle or container suitable for the sterile storage of liquid products therein and the administration therefrom of said products dropwise, the sterility being maintained even after first opening the bottle, without the need to include preservatives in the liquid product. The dispenser comprises a container body (1), a capsule (3) and a dropper assembly (2), ending with a rigid dropper nozzle (5) provided with one or more transversal ports communicating with the interior of the container body (1), covered by a resiliency deformable tubular sleeve (9). The dropper nozzle comprises a first portion having a smaller conicity (6) making out the distal end of the dropper and a second portion having grater conicity (7) on which three of such ports are preferably provided. The closure capsule (3) comprises an internal projection (21) which comes into contact, when the capsule is closed, with the tubular sleeve (9) at the position where the second portion having grater conicity (7) of the dropper nozzle is located.

Abstract: A hollow actuator-driven droplet dispensing apparatus may include an elastic tube having an elastic body, defining a storage space therein, and extending a predetermined length, and a hollow actuator fitted around the elastic tube so as to generate a force and a displacement in the longitudinal direction when an electric field is applied. The hollow actuator is expanded or contracted in the longitudinal direction of the elastic tube when the external voltage is applied, thereby reducing or enlarging the volume of an inner space of the elastic tube. The droplet dispensing apparatus can press the elastic tube to expand or contract the volume of the inner space of the tube using the hollow actuator capable of quickly generating a displacement in response to an application voltage so that a fixed amount of content can be discharged out and taken into the tube.

Abstract: Provided is a droplet dispensing device having a nonconductive capillary nozzle. The droplet dispensing device comprises: a nonconductive capillary nozzle disposed in a downward position; a pump connected with the nonconductive capillary nozzle through a hermetically sealed fluid tube and generating a negative pressure to decrease the influence of gravity on a solution within the nonconductive capillary nozzle and the fluid tube; and an open circuit voltage supplier applying a voltage to the solution. The droplet dispensing device supplies the solution by capillary force to regularly maintain the shape of a droplet surface in the tip of the nonconductive capillary nozzle without using a separate driving device.

Abstract: The present invention relates to a metered drop bottle for dispensing microliter amounts of a liquid in the form of a drop comprising: (a) a bottle with a flexible portion on the walls to decrease the internal volume by a fixed volume; (b) a plunger with a fixed stroke for depressing the flexible portion of the walls of the bottle; and (c) a nozzle tip having an internal and/or outer diameter no more than 1.2 mm.

Abstract: A viscous medium feeder, which has an inlet, an outlet, a tubular portion, a rotatable cylindrical shaft arranged in and extending coaxially with the tubular portion, and a drive motor connected to the shaft. The tubular portion has an internal thread, which is connected, at one end thereof, to the inlet, and, at the other end thereof, to the outlet. Further, the tubular portion is elastic, and the shaft abuts the inner wall portions of the tubular portion.

Abstract: To overcome shortcomings of the prior art, the subject invention is provided which includes various dropper bottle designs and dropper bottle assemblies including accessories for dropper bottles. With certain aspects of the subject invention, improvements in the administration of eye drops is provided by adding accessories or modifications to conventional dropper bottles, so that doses and/or single drops may be administered in a repeatable and reliable manner. More specifically, certain embodiments use devices (10, 300) to restrict the amount the dropper bottle (12) is deformed in administering a dose; other embodiments rely on mechanical reduction of interior volume (without deformation of the dropper bottle (12)) to administer a dose, such as with a displaceable piston (500, 602); and, yet, a further embodiment provides a valving arrangement (402, 404) to limit a dose.

Abstract: An eye care solution container is described that can be conveniently carried without the risk of loss, leakage or misplacement. The eye care solution container has a retention device that allows it to be clipped to a pocket, an article of clothing or an accessory item. The eye care solution container may also be attached to a zipper pull, a key ring, or the like. The eye care solution container may be one of various sizes and shapes, including a unit dose container.

Abstract: The present invention includes devices for containing and dispensing liquid solutions. The devices of the invention increase ease of sample volume control and, hence, application thereof while minimizing any sample spillage or fluid migration up the side of the dispensing tip. Furthermore, the devices provide ensure adequate sample volume.

Abstract: An eyedropper including a container and a cap which can be screwed onto the container unit wherein a tubular fluid instilling portion is provided at a tip of the container. An outer circumferential region of the tubular fluid instilling portion is provided with a step portion where the outer diameter of the container is smaller and whose outer diameter is substantially not reduced or changed moving towards the tip. The cap is provided with a convex seal portion, which, in the mounted condition, is in close contact with the tip and the step portion.

Abstract: A drop system made of a liquid to be provided in drop form in the field of dentistry is contained in a container with a vapor-tight, sealable dropper insert made of light-impermeable plastic and a hollow space running in the dropper insert provided for the supply of a liquid. The hollow space has several tubular sections and a funnel-shaped outlet. The tubular section connecting to the funnel is formed as a tapering or restriction between the funnel-shaped section and another tubular section, and the funnel is arranged in a column-shaped dropper spout. A collection channel is arranged on the outer side of the dropper between the outer wall defining the hollow space and the part of the dropper insert covering the neck of the bottle.

Abstract: To provide a squeeze bottle with reduced pressing force required to delivery a liquid, and particularly a squeeze bottle wherein the pressing force is reduced to such an extent that allows easy control of the discharge of liquid drops even when a valve operated by the liquid pressure is provided. In a squeeze bottle comprising the bottle body 10 for containing a liquid, and a neck 11 that leads to the opening end 10a of the bottle body 10, the bottle body 10 has a bellows 12 which is contracted and expanded in the direction y generally perpendicular to the direction x of delivering liquid. The bellows 12 has a plurality of pleated portions 13 disposed in the direction of delivery x. The pleated portions 13 are disposed at intervals in the direction of contraction y. Further, the width of the convex edge of the pleated portion 13 in the direction of width Z, that is, the distance between the both edges 14, is made to decrease from the middle to the both ends in the direction of contraction y.

Abstract: A bottomed conical hollow 6b is formed in a tip end of the container body A formed of a thermoplastic material with a liquid filled and sealed therein simultaneously during the molding process, the hollow having an inside diameter enlarging toward the tip end, and a small-diameter instilling hole 6c is penetrated through the bottom of the hollow 6b for controlling, at a set quantity, the liquid pushed out of the container body A.

Abstract: A liquid dispensing apparatus for dispensing droplets of a liquid, and methods for measuring various fluid parameters of the liquid are described. The liquid dispensing apparatus comprises a container having a chamber for holding a liquid. An orifice is positioned at an end of the chamber for dispensing droplets of the liquid, the orifice being configured to retain the liquid in the container if the container is positioned with the orifice facing in a downward direction. An acoustic transducer means is at least partially positioned in the chamber for periodically propagating a focused acoustic beam toward the orifice and through at least some of the liquid while the liquid is contained in the chamber, with the focused acoustic beam being capable of causing a droplet of the liquid to be ejected from the orifice when a free surface of the liquid is within the depth of field of the acoustic transducer means.

Abstract: The present dropper comprises an inner container provided with two elastically deformable portions: an ejection drip portion and a suction filling portion; a pusher actuates on this inner container by means of a to-and-fro motion within an outer container. By removing the safety cover the pusher can be operated and, in turn, it actuates compressing the ejection drip portion of the inner container until the liquid material comes out through the drip opening of the drip nozzle. In order to refill the dropper, the inner container is removed, its drip nozzle is applied to the refill liquid material and the filling portion is cross-sectionally compressed and decompressed by suction.

Abstract: In a method for cleaning a liquid delivery device such as a dispensing or pipetting device, the liquid chamber can be flushed in a cleaning step. To remove gas bubbles which might exist in the liquid chamber, for example, the liquid in the liquid chamber is vibrated during the cleaning step.

Abstract: The present invention relates to a droplet microreactor, i.e. a microreactor consisting of a droplet of a specific liquid, the microreactor being wall-less, wherein the interface of the specific liquid with the ambient environment and with the support on which the droplet is deposited defines the limits of the microreactor. The microreactor is characterized in that it consists of a droplet comprising at least one ionic liquid. The present invention also relates to methods for carrying out chemical or biochemical reactions and/or mixes using said droplet microreactor, and also to a lab-on-chip comprising a microreactor according to the invention.