Abstract: A portable, efficient, integrated humidification system for use, e.g., with a positive airway pressure devices. The portable, efficient, integrated humidification system described herein offers many advantages over current humidification systems! There are many advantages to a portable respiratory humidifier. Portability reduces the amount of space the humidifier occupies in the user's bedroom environment. Portability enhances travel for the user. With less to pack, carry, and manage, the user is more likely to remain adherent to therapy when not at home. Portability allows for better utilization in recreational vehicles, while camping, in foreign countries, in the sleeping cabins of trucks or airliners, and on marine craft.

Abstract: An enclosed structure for receiving fog from a fog-producing device. The fog comprises fog particles of water and an active substance that is capable of being aerosolized. A plurality of spaced-apart redirector surfaces is located within the enclosed structure; these surfaces define flow paths for the fog to travel. The fog particles collide with or pass proximate the redirector surfaces, causing the larger fog particles to fall out of the fog flow path, while the smaller fog particles continue along the fog flow path, finally exiting the enclosed structure. After exiting, the fog particles strike a target, with the active substance within the fog particles treating the target.

Abstract: Provided are an ion source and a mass spectrometer that reduce a dead volume of the connecting part of a pipe to a capillary. An ion source has a capillary and a pipe. The capillary has a large-diameter part that forms a capillary upstream-side end face on an upstream side. The large-diameter part has a large-diameter part downstream side face on a downstream side. The pipe has a pipe downstream end face on the downstream side. A capillary retaining unit has a hole through which the capillary downstream-side end face is passable and a face on which the large-diameter part downstream side face is installable. The ion source includes a pipe retaining unit that retains the pipe. The capillary retaining unit and the pipe retaining unit are disposed such that the capillary upstream-side end face contacts the pipe downstream end face to connect the capillary to the pipe.

Abstract: A nebulizer is provided to atomize a liquid medication for rapid delivery of an aerosol spray to a user via inhalation. The nebulizer includes a jar having a compressed gas passage. A jet cooperates with the jar and has a jet orifice through which the liquid medication and the compressed gas are discharged to form an aerosol flow. The cap is connected to the jar to define an inner chamber. The cap includes an entrainment port for ambient room air, and a chimney in fluid communication with the entrainment port and the inner chamber. A deflector base having an impingement member is located adjacent to the entrainment chimney and is spaced below an opening thereof by a predetermined distance to provide a flow of the ambient room air to be entrained in the aerosol flow in order to enhance nebulization speed while maintaining a desired aerosol particle size.

Abstract: This liquid surface detection device comprises: a liquid retention part in which hydrogen peroxide water is retained, the hydrogen peroxide water to be atomized by a vibrating plate in which a through-hole is provided; a float positioned inside the liquid retention part; and a sensor that detects, via the float, the arrival of the liquid surface of the hydrogen peroxide water retained in the liquid retention device at a prescribed position.

Abstract: An aerosolization system includes a respiration system having an inspiratory limb and an expiratory limb. The system includes an aerosol chamber coupled with the inspiratory limb via a fluid channel. The fluid channel is disposed such that the aerosol chamber is isolated from continuous flow passing through the respiratory system. The system includes a patient interface positioned at a first location of the aerosol chamber and an aerosolization device positioned at a second location of the aerosol chamber positioned opposite the first location. The aerosolization device includes a reservoir that receives a volume of liquid medicament for aerosolization by the aerosolization device. The aerosol chamber mixes aerosolized medicament from the aerosolization device with respiratory flow received from the respiration system via the fluid channel.

Abstract: A method of delivering aerosolized surfactant to an infant that includes interfacing an aerosolization device with an airway of an infant and aerosolizing, using the aerosolization device, a volume of surfactant into particles having a mass mean aerodynamic diameter (MMAD) of less than about 3 ?m at a rate of at least 0.1 ml/min. The surfactant is aerosolized within about 1 to 8 cm from a patient interface. Aerosol is generated for up to approximately 80% or each inspiration. The method also includes delivering the aerosolized surfactant to the infant's airway.

Abstract: The present invention is directed to a dispensing system, device, and method for the dispensing of a fluid supplement such as in the form of a concentrated fluid containing flavoring, nutrients, medication, and/or other supplements. Certain embodiments of the invention as disclosed herein comprise a handheld apparatus which allows the dispensing of predetermined amount of a fluid with single-handed use. Certain embodiments include self-contained pods which is controlled by a removable dispenser to allow for multiple types of fluids, and preventing cross-contamination within the dispenser.

Abstract: A inhaler includes a piezoelectric element substrate having an IDT constructed by use of a pair of interlocking comb-shaped metallic electrodes, a liquid supplier for supplying liquid, which is to be atomized, to a front surface of the piezoelectric element substrate on which the pair of interlocking comb-shaped metallic electrodes is positioned, a sensor, which includes at least a pair of detection parts which are opposite to each other, for detecting liquid supplied to the front surface of the piezoelectric element substrate, and a controller for controlling, based on result of detection by the sensor, the liquid supplier in such a manner that the liquid supplier supplies a certain quantity of the liquid to the front surface of the piezoelectric element substrate.

Abstract: A hand-held cosmetic dispenser having a housing with a first end and a second end, the housing having a nozzle coupled to a first end of the housing, a power source disposed within the housing, a spray button coupled to the housing, a cosmetic fluid compartment disposed within the housing and configured to receive and retain a fluid cosmetic, a gas compartment configured to receive and retain a gas canister, and a gas controlling system disposed within the housing. The gas controlling system has and air-tight coupler configured for coupling to the gas canister, a control mechanism that controls how much gas can leave the gas canister, and a tube that connects the gas compartment to the cosmetic fluid compartment. The power source is electrically coupled to the spray button and the gas controlling system. A method of using the same.

Abstract: The disclosure provides a liquid administering device capable of accurately administering a liquid to a predetermined part in a nasal cavity. A liquid administering device 2 includes a main body 4, a first nozzle 6 that protrudes from the main body 4 in a predetermined direction and dispenses a liquid while being inserted into one nasal cavity 28a of a user, and a second nozzle 8 that protrudes from the main body 4 in the predetermined direction and is inserted into the other nasal cavity 28b of the user to position the first nozzle 6 with respect to one nasal cavity 28a.

Abstract: A lubricating system that includes a manifold with one or more manifold ports that permit a flow of lubricant through the manifold. The manifold is configured for removable attachment to another manifold such that any number of manifold can be joined together. An ejector is removably attached to the manifold. The ejector has one or more projections configured for insertion into each of the one or more manifold ports in the manifold, such that the ejector is configured to receive the flow of lubricant from the manifold, via the one or more projections, and to discharge lubricant periodically, or at preset intervals, from one or more outlet ports of the ejector. A locking key is disposed between the manifold and ejector. The locking key is configured such that movement of the locking key attaches or detaches the ejector from the manifold.

Abstract: A method of manufacturing an orifice is provided to make the orifice capable of spraying a very small amount of fluid in an ultra-high pressure and very low temperature environments. The method also makes it possible to provide the orifice with reduced volume and mass. More specifically, the method effectively realizes a desired hydraulic performance through a simple manufacturing method in which a part of a capillary pipe is pressed to form a channel region having a cross section close to a rectangular shape.

Abstract: Methods and systems are described herein for fluid handling and dispensing liquid substances using vaporization or nebulization in a controlled, safe manner. A dispensing device may be configured to receive one or more cartridges storing different types of vaporizable or nebulizable substances. A controller may be provided to regulate the amount of a given substance dispensed over a defined time period. Optionally, in response to detecting tampering of the dispensing device and/or a liquid cartridge the dispensing device may be disabled and/or a liquid stored in a substance cartridge may be rendered inert.

Abstract: The present disclosure provides aerosol delivery devices having a variety of configurations and arrangements. Some aspects of the disclosure provide aerosol delivery devices having a first pump configured to deliver a flow of air; a second pump configured to deliver a flow of liquid; and a nozzle configured to receive the flow of air and the flow of liquid and output the liquid in an atomized form.

Abstract: The invention relates to a device including a nanoaerosol nozzle for releasing an aerosol with very fine particles.

Abstract: The invention relates to a nebulizer (1) comprising an aerosol generator (6), a nebulizing chamber (5) and an outlet (16), the aerosol generator (6) being designed to release an aerosol into the nebulizing chamber (5) and the outlet (16) being designed to allow the removal of the aerosol from the nebulizing chamber (5). To achieve a high output rate, a wetting surface (2) is provided in the nebulizing chamber (5).

Abstract: An aerosol generator with electrical power conducting pins has a vibratable plate with apertures therein and an annular piezo. An annular support member supports the piezo and the vibratable plate. A first electrical power conducting pin engages directly with a first, top, surface of the piezo. A second electrical power conducting pin indirectly conducts electrical power to a second surface of the piezo, by contacting an extension tab. There is a film of cured epoxy adhesive on the tab. The aerosol generator avoids need for soldered joints for electrical contact, and the pins are conveniently mounted parallel to each on the same lateral and top side of the piezo and support member. The pins may have multi-point tips for particularly effective electrical contact.

Abstract: This invention is a novel aroma candle light including a light body, a water spray formation channel, an ultrasonic device and a water tank; a water spray outlet is formed on a top part of the water spray formation channel; an LED light panel is fixedly mounted at the water spray outlet; the ultrasonic device includes an ultrasonic plate, an ultrasonic plate fixing member and a silicone rubber casing; the ultrasonic plate is disposed inside the silicone rubber casing; the ultrasonic plate fixing member has a top end which is provided with a recess; the silicone rubber casing is mounted inside the recess; the silicone rubber casing has a top part which is provided with a plurality of first guiding grooves; a plurality of second guiding grooves are formed inside the recess; the ultrasonic plate fixing member is disposed at an opening at a top part of the water tank.

Abstract: The present invention provides a method for analyzing a sample containing metal fine particles with an inductive coupling plasma mass spectrometer. The method enables analysis of the sample without the need of standard metal fine particles. Specifically, the present invention relates to a method for analyzing metal fine particles in liquid by use of an inductive coupling plasma mass spectrometer. In the method, the analysis apparatus is provided with a standard solution introduction apparatus including a standard solution storage unit for storing a standard solution containing a specific element in a known concentration, a syringe pump for suctioning and discharging the standard solution, and a solution introduction unit having a standard solution nebulizer and a standard solution spray chamber that are supplied with the standard solution, the standard solution is directly supplied to the standard solution nebulizer at a flow rate of 3 ?L/min or less.

Abstract: A smoke generator includes an oil tank receiving an oil to be pumped by an oil pump to a vaporization tube where the oil vaporized into smoke after heating by a heater. A pre-pressurization oil supply device is disposed between the vaporization tube and the oil pump. When the pre-pressurization oil supply device is in a non-supply state not intercommunicating with the vaporization tube, the pre-pressurization oil supply device maintains its internal pressure, and the oil in the pre-pressurization oil supply device is not delivered to the vaporization tube. When the pre-pressurization oil supply device is in an oil supply state, the pre-pressurization oil supply device intercommunicates with the vaporization tube, and the oil in the pre-pressurization oil supply device is rapidly delivered to the vaporization tube.

Abstract: A delivery device for intravenous delivery of microparticles to a patient. The delivery device is fluidly connectable to (i) a first source of an injection medium and (ii) a second source of an injection medium. The delivery device includes: a first fluid inlet fluidly connectable to the first source of the injection medium, a fluid outlet, a fluid mixer fluidly connecting the first fluid inlet to the fluid outlet, a second fluid inlet fluidly connectable to the second source of the injection medium, and a source of microparticles fluidly connecting the second fluid inlet to the fluid mixer. When fluid flows from the second source of the injection medium into the delivery device: the second injection medium fluidly drives microparticles from the source of microparticles into the fluid mixer, and the fluid outlet dispenses to the patient an injection medium that includes the microparticles.

Abstract: An atomiser, in particular an inhaler, for atomising a liquid active agent to form an aerosol, having, inter alia, an active agent reservoir, an atomiser nozzle and a pump arrangement, wherein a suction side of the pump arrangement leads into the active agent reservoir and a pressure side of the pump arrangement leads into the atomiser nozzle, and wherein the pump arrangement has a plunger that can be adjusted in a cylinder in the axial direction of the cylinder. A corresponding method is also described.

Abstract: An inhalation device having a reservoir for storing liquid before being discharged, and a discharge head for dispensing the liquid in droplet mist. The discharge head has a nozzle arrangement for generating the droplet mist and housing on which a discharge channel is provided for use as a respiration piece or for attachment of a separate respiration piece. A main axis of extent of the discharge channel encloses an angle of >0° with a central dispensing direction. In alignment with the central dispensing direction of the nozzle arrangement, either an aperture is provided in the housing through which aperture the droplet mist emerges from the discharge head if it is not sucked into the discharge channel by respiration of the user, or a liquid buffer is provided for receiving the droplet mist if it is not sucked into the discharge channel by respiration of the user.

Abstract: Provided is a latex-based composition capable of being applied to a surface to form a strippable coating on the surface that can encapsulate substances. The composition may include a latex polymer component and an anti-freeze component, and have a viscosity of less than or equal to about 90 cP. The composition may be delivered as an aerosol spray or a misting agent.

Abstract: An electronic vaping device is provided including a power supply portion comprising a power supply, an atomizer/liquid reservoir portion comprising a liquid reservoir storing a liquid, and an atomizer adapted to atomize the liquid stored in the liquid reservoir when operated by the power supply. The atomizer is adapted to float on the surface of the liquid in the liquid reservoir.

Abstract: The invention relates to methodologies of obtaining a controlled exposure of an aerosol to a model material. The invention also provides an exposure cap and a system for studying or predicting the interaction between a model material, e.g. a cell, and an aerosolized agent. The controlled exposure of the aerosol to the model material, makes is possible to accurately calculate the mass-balance of the aerosol exposure.

Abstract: An anti-condensation housing includes a connector to connect to a diffusing head configured to nebulize a product to diffuse. The housing includes a conduit having an inlet for a nebulized product, an outlet opening at a diffusing end, of the conduit, a fan at an insufflating end of the conduit. The fan generates a flow of air between the insufflating end and the diffusing end of the conduit. An internal surface of the conduit extending along a direction perpendicular to the direction of the air flow creates an obstacle for the progress of the air flow in the conduit. A retainer to retain the nebulized product stopped by the internal surface. A device to diffuse a product implementing the anti-condensation housing and a method for diffusing a product using such a device are provided.

Abstract: Apparatuses and methods for a spray system with dynamically configurable droplet sizes are disclosed.

Abstract: An ultrasonic topical applicator and method is provided for dispensing a topical including an adjustable head including a mesh nebulizer having a perforated plate with a plurality of pores and a vibrating actuator, a cartridge having a reservoir for holding a topical and a port configured to secure the reservoir to the mesh nebulizer, and a handle including a power source and a controller configured to control energy from the power source to the mesh nebulizer based on an energy profile, where the vibrating actuator is configured to produce ultrasonic vibration based on the energy profile, and where the adjustable head is configured to lock into within the handle and to allow the adjustable head to rotate.

Abstract: A laser using a laser diode and a narrow wavelength from a resonant atomic transition of a predetermined material. The gain range of the laser diode encompasses the wavelength of the resonant atomic transition. A vapor cell containing a material, such as a metal vapor, providing the resonant atomic transition forming the predetermined wavelength is placed between permanent magnets. In one embodiment the vapor cell has opposing windows positioned at a Brewster's angle and rotated 90° relative to each other. The laser produces a very narrow bandwidth of a predetermined wavelength with high power. The laser configuration eliminates several optical components reducing cost.

Abstract: The present invention relates to a nebulizer mesh which is used, in a nebulizer for atomizing and nebulizing liquid, for atomizing the liquid, and has plural through holes 17, wherein each of the through holes 17 forms a cylindrical space portion 174 on one surface side of the nebulizer mesh, and forms an opening 172 opened in a mortar shape on the other surface side, and to a production method thereof.

Abstract: The present invention relates to an aroma diffuser with direct diffusion of essential oil, and an aroma diffusing method. The aroma diffuser comprises a base, a housing mounted on the base and an electric control element disposed on the housing. An essential oil bottle and a gasification element are also disposed on the housing, a pump element is disposed inside the housing and the open end of the essential oil bottle is connected to the lower end of the gasification element. The pump element is connected to the gasification element and the electric control element respectively and communicates with the gasification element. The gasified essential oil gas may be diffused to ambient air directly, rather than through the housing, the diffusion is fast, and the directly diffused essential oil does not need the dilution of water, greatly raising the efficiency of aromatherapy and meeting people's use requirements.

Abstract: A nozzle, an inhaler with a nozzle and a method for producing a nozzle are proposed, which nozzle comprises two holes formed in a flat plate which plate is then deformed such that the axes of the holes intersect so that jets of fluids moving through the holes impinge with each other.

Abstract: Systems and methods are described for laser ablation of an analyte from a specimen and capturing of the analyte in a dispensed solvent to form a testing solution. A solvent dispensing and extraction system can form a liquid microjunction with the specimen. The solvent dispensing and extraction system can include a surface sampling probe. The laser beam can be directed through the surface sampling probe. The surface sampling probe can also serve as an atomic force microscopy probe. The surface sampling probe can form a seal with the specimen. The testing solution including the analyte can then be analyzed using an analytical instrument or undergo further processing.

Abstract: Disclosed is a constant quantity control nebulization device including a main body, a nebulization module, a fixing plate and a rotary ring, and the device is installed to a container that contains a liquid to be nebulized. A first liquid storage space with a predetermined volume is defined at the top of the main body, and the nebulization module is installed in the main body and interconnected to the first liquid storage space, and the fixing plate is fixed onto the main body and has a first through hole, the rotary ring is sheathed on the top of the main body and axially coupled to the fixing plate, and the rotary ring has a second through hole corresponding to the first through hole. The consumption of the liquid to be nebulized can be controlled by rotating the rotary ring to improve the convenience of operation significantly.

Abstract: A spray generator (10) including: a membrane (40) having a perforate portion through which, in use, a fluid is caused to flow when the membrane (40) is vibrated; an electronically-driven or a piezoelectrically driven actuator for vibrating the membrane (40); a chamber (18) for storing fluid for supply to a surface of the membrane (40); and a sealing element (13) located in and movable within the chamber (18) between a first position in which fluid flow from the chamber (18) through the membrane (40) is prevented and a second position in which fluid flow from the chamber (18) through the membrane (40) is allowed.

Abstract: A nebulizer includes a piezoelectric transducer for aerosolizing a drug solution in a disposable cup module disposed above the transducer. Acoustic waves generated by the transducer propagate sequentially through transmitting medium, a first barrier, coupling medium, and a second barrier that forms part of the cup module, and into the interior of the cup module. The transducer at least partially comprises silver. The silver fluidly contacts the transmitting medium to discourage bacteria growth in the transmitting medium. The device includes electronics components that drive the transducer and measure an electrical characteristic associated with the transducer during operation. The electronics components measures changes in the electrical characteristic to determine when the drug solution level falls below a predetermined threshold, and deactivates the device accordingly.

Abstract: The present invention provides a brush wheel typed nebulizer, comprising: a drive device; a spiral pump, including a body, an outer sleeve, in which the outer periphery of the body is installed with at least a helicoid member closely attached to an inner sleeve having a flow opening inside the outer sleeve; a brush wheel, configured with multiple implant holes and having brush hairs forming at least a ditch; a sleeve lid, on which a notch is configured in correspondence with the end of the brush hair, and an inner bulge acting conjunctively with the end of the brush hair and having multiple guide grooves. With such a design, it is possible to fling off the highly viscous liquid attached on the brush hair to create atomized liquid of extremely tiny microdrops.

Abstract: Amino acid sequences are provided that are directed against and/or that can specifically bind protein F of hRSV, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The amino acid sequences, polypeptides and therapeutic compounds and compositions provided by the invention show an improved stability, less immunogenicity and/or improved affinity and/or avidity for protein F of hRSV. The invention also relates to the uses of such amino acid sequences, polypeptides, compounds or constructs for prophylactic and/or therapeutic purposes.

Abstract: A removable replaceable cartridge for use with a liquid diffusing device. The cartridge includes a venturi, a conduit extending to the venturi, a mixing area and an outlet path for atomizing and dispersing a liquid within the cartridge. A diffusion device including a removable replaceable cartridge received within a housing. The housing includes a source of compressed gas which is directed into the cartridge. A venturi head with a unitary body for use with a diffusion device.

Abstract: A method of safely delivering an ophthalmic fluid to an eye, the method including targeting the eye with an ophthalmic fluid misting device and activating an ultrasonic generator to deliver the ophthalmic fluid from the ophthalmic fluid misting device across a space between the misting device and the eye. The method further including maintaining a momentum of the ophthalmic fluid that is insufficient to trigger at least one of the ocular blink reflex and the lacrimation reflex of the eye.

Abstract: Dispensing devices are disclosed that include a base, a reservoir that has a volatile active, and a housing. The housing includes a horizontal component and a vertical wall extending upwardly from the horizontal component. The horizontal component and the vertical wall define an interior volume of the housing. An activator is operatively connected to the reservoir. When the activator is activated, the volatile active is released from the reservoir into the interior volume of the housing to create a first quantity of volatile active having a first emanation rate and a second quantity of volatile active having a second emanation rate.

Abstract: A system for fragrancing air includes an adjustable fan that is used to generate an air flow to push atomized fragrance oil from an output orifice of the system. The fragrance in the air is generated from atomized fragrance oil, where liquid fragrance oil can be stored in a cartridge bottle assembly and then atomized with compressed air in a collector assembly in the system. When the system is mounted on a wall or ceiling, the adjustable fan can be used to direct the fragrance downward at any number of angles from the system. The system can be programmed to adjust a fan speed and various settings of the fragrance delivery.

Abstract: A nanoparticle aerosol generator, comprised of a vibrating fluidized bed with a baffle, a vibrating Venturi disperser and a cyclone separator. To generate nanoparticle aerosols, the nanoparticle aerosol generator uses the multiple impaction, vibrating air flow and vibrating high speed air flow to break up larger agglomerates, and multiple dilution to minimize the re-agglomeration of the particles.

Abstract: A closed nebulizing system for removing bubbles includes a first pump, a nebulizing module and a second pump. The first pump is for providing a fluid. The nebulizing module includes an outlet channel, an inlet channel connected with the first pump, and a plurality of nozzles for nebulizing and ejecting part of the fluid. The second pump is connected with the outlet channel for outputting non-nebulized fluid. The first pump, the nebulizing module and the second pump form a closed fluid loop, so that the fluid continuously contacts with the plurality of nozzles and bubbles generated during nebulization process are evacuated from the nebulizing module.

Abstract: A nebulizer for efficiently and reliably delivering aerosolized fluid to an inhaling patient is disclosed. The nebulizer includes a fluid channel air inlet and fluid channel air inlet valve responsive to either a manual force external of the nebulizer, or a patient's breathing, to begin the nebulization process. Also provided is a method of providing nebulization including the steps of moving a fluid channel air inlet valve against a fluid channel air inlet so that a negative pressure may build up over the fluid in the fluid channel to draw fluid from the fluid reservoir and begin nebulization during inhalation.

Abstract: An automatically alignable conformal, cup-shaped fluidic nozzle engineered to generate an oscillating spray is configured as a cylindrical cup having a substantially open proximal end and a substantially closed distal end wall with a centrally located power nozzle defined therein and between first and second distally projecting alignment tabs or wall segments. Optionally, the fluidic circuit's oscillation inducing geometry is molded directly into the sealing post's distal surface and a one-piece cup provides the discharge orifice.

Abstract: A nebulizer kit includes a case body having a compressed air introduction tube in an upper end portion of which is a nozzle hole that expels compressed air, a suction channel formation member forming a suction channel for sucking liquid toward the upper end portion and forming an atomizing area in an exit region of the hole, and a flow channel formation member having an aerosol discharge port. The suction channel has first and second suction channels respectively extending upward along an outer circumferential surface of the tube and from the suction channel toward the hole at a leading end area of the tube and has a liquid suction port that expels the liquid. A particle segregating portion having a blade portion, whose orientation to the atomizing area is adjustable, is between the atomizing area and the port. The suction channel formation member is fixed to the case body.

Abstract: The invention relates to a turbo-inhaler, comprising an active-liquid container (1) holding a liquid having an active ingredient dissolved therein, a nebulizer (2), by means of which liquid can be converted into an aerosol and introduced into a blade housing (3), in which a bounding dome (4) is suspended, the concave side (41) of which is directed at the nebulizer, an exhaust air duct (5), which is connected to the blade housing in the area of the convex side (42) of the bounding dome, and a supply-air guide (6), by means of which supply air can be introduced between the blade housing and the active ingredient, wherein at least one guide blade (7) is placed on the convex side of the bounding dome and spirally extends thereon.