Methods Patents (Class 250/459.1)
  • Patent number: 10654655
    Abstract: A stuck slide determination system is provided that determines if a slide (e.g., glass slide), positioned on a scanning stage at the start of the scanning process, gets stuck and does not move along with the scanning stage after the scanning process commences. In an embodiment, the system includes a sensor having a transmitter and receiver that are relatively positioned to detect the presence of the stage or a slide or the absence of the stage or a slide. When the scanning stage begins to move at the start of the scanning process, a processor monitors a signal from the sensor and determines if the slide is improperly positioned after the scanning process has commenced. If the slide is improperly positioned, the processor stops movement of the scanning stage in order to protect the slide from damage.
    Type: Grant
    Filed: October 4, 2018
    Date of Patent: May 19, 2020
    Inventors: Nicholas Newberg, Prentash Djelosevic, Aaron Stearrett, Peyman Najmabadi
  • Patent number: 10644254
    Abstract: To provide a light-emitting element which uses a fluorescent material as a light-emitting substance and has higher luminous efficiency. To provide a light-emitting element which includes a mixture of a thermally activated delayed fluorescent substance and a fluorescent material. By making the emission spectrum of the thermally activated delayed fluorescent substance overlap with an absorption band on the longest wavelength side in absorption by the fluorescent material in an S1 level of the fluorescent material, energy at an S1 level of the thermally activated delayed fluorescent substance can be transferred to the S1 of the fluorescent material. Alternatively, it is also possible that the S1 of the thermally activated delayed fluorescent substance is generated from part of the energy of a T1 level of the thermally activated delayed fluorescent substance, and is transferred to the S1 of the fluorescent material.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: May 5, 2020
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Satoshi Seo, Hiromi Seo, Tatsuyoshi Takahashi
  • Patent number: 10629404
    Abstract: A method of adjusting a particle beam microscope includes measures A, B, C and D.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: April 21, 2020
    Assignee: Carl Zeiss Microscopy GmbH
    Inventor: Dirk Preikszas
  • Patent number: 10627352
    Abstract: Apparatus and methods are disclosed for employing an accelerated neutral beam derived from an accelerated gas cluster ion beam as a physical etching beam for providing reduced material mixing at the etched surface, compared to previous techniques. This results in the ability to achieve improved depth profile resolution in measurements by analytical instruments such as SIMS and XPS (or ESCA) analytical instruments.
    Type: Grant
    Filed: August 21, 2012
    Date of Patent: April 21, 2020
    Assignee: Exogenesis Corporation
    Inventors: Sean R. Kirkpatrick, Allen R. Kirkpatrick
  • Patent number: 10620251
    Abstract: Sensing the electric or strain field experienced by a sample containing a crystal host comprising of solid state defects under a zero-bias magnetic fields can yield a very sensitive measurement. Sensing is based on the spin states of the solid-state defects. Upon absorption of suitable microwave (and optical) radiation, the solid-state defects emit fluorescence associated with hyperfine transitions. The fluorescence is sensitive to electric and/or strain fields and is used to determine the magnitude and/or direction of the field of interest. The present apparatus is configured to control and modulate the assembly of individual components to maintain a zero-bias magnetic field, generate an Optically Detected Magnetic Resonance (ODMR) spectrum (with or without optical excitation) using appropriate microwave radiation, detect signals based on the hyperfine state transitions that are sensitive to electric/strain fields, and to quantify the magnitude and direction of the field of interest.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: April 14, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Danielle Ann Braje, Edward H. Chen, Phillip R. Hemmer
  • Patent number: 10612085
    Abstract: A mechanism is provided for reducing entropy of a polyelectrolyte before the polyelectrolyte moves through a nanopore. A free-standing membrane has the nanopore formed through the membrane. An agarose gel is formed onto either and/or both sides of the nanopore in the membrane. The agarose gel is a porous material. The polyelectrolyte is uncoiled by driving the polyelectrolyte through the porous material of the agarose gel via an electric field. Driving the polyelectrolyte, having been uncoiled and linearized by the agarose gel, into the nanopore is for sequencing.
    Type: Grant
    Filed: June 23, 2015
    Date of Patent: April 7, 2020
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Gustavo A. Stolovitzky, George F. Walker, Chao Wang, Deqiang Wang
  • Patent number: 10605657
    Abstract: Some embodiments include a scanning module with an optical reader coupled to a moveable carriage configured to move the optical reader in a first direction. In some embodiments, the optical reader includes excitation sources, emission detectors, emission energy conditioning elements, and a tape drive configured and arranged to selectively advance a tape in a second direction which is substantially perpendicular to the first direction. Further, some embodiments include a bar code reading station positioned adjacent to the moveable carriage. Other embodiments include an objective lens.
    Type: Grant
    Filed: March 19, 2018
    Date of Patent: March 31, 2020
    Assignee: DOUGLAS SCIENTIFIC, LLC
    Inventors: Adnanul Haq, Richard J. Schoeneck
  • Patent number: 10599037
    Abstract: Systems and methods which provide anti-counterfeiting patterns tagged with multi-mode nanotaggants, such as may comprise single-mode nanoparticles, multi-mode nanoparticles, or a combination thereof, are described. The multi-mode nanotaggants of embodiments are configured to exhibit prescribed emissions by excitation at distinct stimulus wavelengths. Decryption of anti-counterfeiting patterns tagged with multi-mode nanotaggants of embodiments of the invention may be achieved by examining temporal color responses of the pattern to varying illuminations. In addition to the various color codes that may be encrypted into an anti-counterfeiting pattern using nanotaggants, embodiments provide various graphic codes that may be encrypted into anti-counterfeiting patterns. Such graphic codes may not only comprise the graphic pattern of the anti-counterfeiting pattern itself, but one or more graphic patterns of nanotaggants of the anti-counterfeiting pattern.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: March 24, 2020
    Assignee: City University of Hong Kong
    Inventors: Feng Wang, Tianying Sun, Xian Chen
  • Patent number: 10578850
    Abstract: A fluorescence microscopy inspection system includes light sources able to emit light that causes a specimen to fluoresce and light that does not cause a specimen to fluoresce. The emitted light is directed through one or more filters and objective channels towards a specimen. A ring of lights projects light at the specimen at an oblique angle through a darkfield channel. One of the filters may modify the light to match a predetermined bandgap energy associated with the specimen and another filter may filter wavelengths of light reflected from the specimen and to a camera. The camera may produce an image from the received light and specimen classification and feature analysis may be performed on the image.
    Type: Grant
    Filed: April 30, 2019
    Date of Patent: March 3, 2020
    Assignee: NANOTRONICS IMAGING, INC.
    Inventors: Matthew C. Putman, John B. Putman, Vadim Pinskiy, Denis Sharoukhov
  • Patent number: 10578601
    Abstract: A photostimulation apparatus includes an objective lens arranged to face a biological object, a light source configured to output light to be radiated toward the biological object via the objective lens, a shape acquisition unit configured to acquire information about a shape with a refractive index difference in the biological object, a hologram generation unit configured to generate aberration correction hologram data for correcting aberrations due to the shape with the refractive index difference on the basis of the information acquired by the shape acquisition unit, and a spatial light modulator on which a hologram based on the aberration correction hologram data is presented and which modulates the light output from the light source.
    Type: Grant
    Filed: July 26, 2018
    Date of Patent: March 3, 2020
    Assignee: HAMAMATSU PHOTONICS K.K.
    Inventors: Naoya Matsumoto, Koyo Watanabe, Hirotoshi Terada
  • Patent number: 10564104
    Abstract: The present invention relates to DNA sequencing with reagent cycling on the wiregrid. The sequencing approach suggested with which allows to use a single fluid with no washing steps. Based on strong optical confinement and of excitation light and of cleavage light, the sequencing reaction can be read-out without washing the surface. Stepwise sequencing is achieved by using nucleotides with optically cleavable blocking moieties. After read-out the built in nucleotide is deblocked by cleavage light through the same substrate. This ensures that only bound nucleotides will be unblocked.
    Type: Grant
    Filed: November 8, 2017
    Date of Patent: February 18, 2020
    Assignee: Koninklijke Philips N.V.
    Inventors: Reinhold Wimberger-Friedl, Johan Lub, Pieter Jan Van Der Zaag
  • Patent number: 10557969
    Abstract: An optical component may be provided having a substrate with a first refractive index, in which space regions with a second refractive index are arranged, wherein the optical component contains at least one optical metamaterial, which contains a plurality of individual pixels each comprising a space region which has the first or the second refractive index, wherein the substrate contains at least one polymer. Further, a sensor may be provided with such an optical component and a process for measuring any of an expansion or a temperature.
    Type: Grant
    Filed: September 20, 2017
    Date of Patent: February 11, 2020
    Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Wolfgang Schade, Michael Köhring, Konrad Bethmann
  • Patent number: 10551604
    Abstract: Systems and methods for confocal imaging are described. In one implementation, a confocal imaging system may include a light source configured to emit excitation light having one or more wavelengths, a sample holder configured to hold a sample, a two-dimensional (2-D) imaging device, a first set of optical elements, and a second set of optical elements. The first set of optical elements may include a first spatial light modulator (SLM) and at least one lens. The first set of optical elements may together be configured to collimate the excitation light, apply a predetermined phase modulation pattern to the collimated excitation light, and illuminate the sample in an excitation pattern.
    Type: Grant
    Filed: May 27, 2017
    Date of Patent: February 4, 2020
    Assignee: VERILY LIFE SCIENCES LLC
    Inventors: Cheng-Hsun Wu, Charles Santori, Supriyo Sinha
  • Patent number: 10539506
    Abstract: A microscopy imaging system is disclosed.
    Type: Grant
    Filed: October 23, 2017
    Date of Patent: January 21, 2020
    Assignee: TSINGHUA UNIVERSITY
    Inventors: Qionghai Dai, Ziwei Li
  • Patent number: 10535835
    Abstract: A display apparatus includes a protective film, a display panel, a cushion unit, and a first adhesive layer. The display panel is formed on the protective film, and includes a substrate and a display apparatus formed on the substrate. The cushion unit is formed on the protective film opposite to the display panel, and includes a cushion layer, a first cover layer, and a second cover layer. The first adhesive layer is formed between the first cover layer and the protective film. The cushion layer includes a plurality of pores formed on a first surface and a second surface opposite to the first surface thereof. The first cover layer is formed on the first surface. The second cover layer is formed on the second surface.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: January 14, 2020
    Assignee: SAMSUNG DISPLAY CO., LTD.
    Inventor: Jiwon Han
  • Patent number: 10488146
    Abstract: A toy gun capable of illuminating soft projectile being ejected therefrom, comprising a gun body, a grip assembly is fixedly attached to the gun body, and a trigger assembly mounted on the grip assembly. The gun body has a power source, a motor, a launch assembly with a launch tube, and a light reflecting unit. When the trigger assembly of the toy gun is actuated, the power source activates the motor and switches on the light source. The activated motor causes the launch assembly to discharge a soft projectile in the launch tube and the light emitted from the light source is reflected by the light reflecting unit onto the soft projectile once it is discharged, thereby illuminating the soft projectile.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: November 26, 2019
    Inventor: Siew Buan Quek
  • Patent number: 10488340
    Abstract: Methods and systems are disclosed for extracting an image of a target fluorophore in a biological material, which involve inducing both autofluorescence of the biological material and fluorescence of the fluorophore, acquiring an image arising from both the autofluorescence of the biological material and the fluorophore, and an image arising only from the autofluorescence, subtracting the two images to produce an image representing only the fluorophore, wherein relative intensities of the excitation light used to induce the autofluorescence and the fluorescence are modulated prior to acquiring the images.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: November 26, 2019
    Assignee: Novadaq Technologies ULC
    Inventors: Eduardo Hiroyuki Moriyama, Chun Ho Sze
  • Patent number: 10488470
    Abstract: The disclosure relates to a method for measuring a current using a diamond material. The diamond material has at least one nitrogen deposit and an imperfection in a crystal lattice of the diamond material, adjacent to the nitrogen deposit. The method comprises a providing step, a detecting step and an evaluating step. In the providing step, electromagnetic waves are provided to excite the diamond material. In the evaluating step, an intensity of a fluorescence of the diamond material is detected. In the evaluating step, the intensity and a frequency of the electromagnetic waves are evaluated in order to determine a magnetic field strength influencing the fluorescence.
    Type: Grant
    Filed: March 8, 2016
    Date of Patent: November 26, 2019
    Assignee: Robert Bosch GmbH
    Inventors: Theresa Lutz, Frank Schatz, Robert Roelver
  • Patent number: 10488344
    Abstract: The present invention is directed toward the early detection of harmful algal blooms. The system employs the ability of whole cell non-contact micro Raman spectroscopy to detect cell pigmentation in such a way that distinct patterns or fingerprints can be assembled. Light field microscopy will provide a fundamentally innovative increase in image and sample volume. Furthermore, darkfield microscopy is employed to capture high-resolution, color images of the detected plankton to increase the accuracy of species identification and classification. Together, this new instrument will provide a powerful yet elegantly simple solution to detection of HAB cells and characterization of environmental conditions.
    Type: Grant
    Filed: June 14, 2019
    Date of Patent: November 26, 2019
    Assignee: Woods Hole Oceanographic Institution
    Inventor: Scott M. Gallager
  • Patent number: 10481094
    Abstract: The present disclosure discloses a total internal reflection fluorescence imaging system and a sequencing device. The total internal reflection fluorescence imaging system includes a first imaging system and a second imaging system. The first imaging system includes N separate laser light paths. The second imaging system determines the changes of the height of the sample by means of the differences of the positions at which the second receiving device acquires the second images, and performs automatic compensation according to the changes of the height of the sample, so as to ensure that the sample is always at a focused position. The embodiment can perform light path adjustment of the N separate laser light paths respectively by means of the second imaging system, so as to realize that the N separate laser light paths have the same penetration depth. Therefore no further light path adjustment is required when switching between different light sources, thus saving the time consuming for light path adjustment.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: November 19, 2019
    Assignee: GeneMind Biosciences Company Limited
    Inventors: Liangjin Ge, Luyang Zhao, Ping Wu, Qin Yan
  • Patent number: 10482605
    Abstract: A method comprises obtaining a first cell image of a cell by a first observation method, obtaining a second cell image of the cell by a second observation method that is different from the first observation method, and determining the region of the cell based on the first cell image and the second cell image.
    Type: Grant
    Filed: December 27, 2016
    Date of Patent: November 19, 2019
    Assignees: SYSMEX CORPORATION, NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
    Inventors: Kazumi Hakamada, Yuki Aihara, Masaya Okada, Toshiyuki Sato, Ichiro Sekiya, Eiji Kobayashi
  • Patent number: 10466470
    Abstract: A configurable optical device may include an optical transducer, a multi-lens arrangement, and a controllable optical modulator. The optical transducer is configured to convert light to electrical signals or to convert electrical signals to light. The multi-lens arrangement is positioned to redirect at least some of the light to or from the optical transducer. The controllable optical modulator is provided between the multi-lens arrangement and the optical transducer. The controllable optical modulator is coupled to receive and spatially modulate light to or from the optical transducer. The optical modulator is selectively controllable to steer and/or shape the light to a selected distribution of light from the multi-lens arrangement onto the optical transducer and/or from the optical transducer onto the multi-lens arrangement.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: November 5, 2019
    Assignee: ABL IP HOLDING LLC
    Inventors: An Mao, David P. Ramer
  • Patent number: 10458626
    Abstract: A light system is provided. The light system includes: (a) a lamp head assembly, the lamp head assembly including (i) driver circuits, and (ii) a cooling system; and (b) a replaceable assembly connected to the lamp head assembly, the replaceable assembly including (i) a plurality of light producing elements, (ii) a cooling structure for receiving a cooling fluid from the cooling system, the plurality of light producing elements being supported by the cooling structure, and (iii) a reflector for receiving light from the plurality of light producing elements. The replaceable assembly is separable, as a single assembly, from the lamp head assembly.
    Type: Grant
    Filed: January 17, 2018
    Date of Patent: October 29, 2019
    Assignee: Heraeus Noblelight America LLC
    Inventors: William E. Johnson, III, Ruben C. Manikkam, Mahmood Gharagozloo, Darrin Leonhardt
  • Patent number: 10451538
    Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: October 22, 2019
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Bahram Jalali, Eric Diebold, Brandon Buckley
  • Patent number: 10451555
    Abstract: A surface plasmon fluorescence analysis device that has a chip holder, a light source, an angle adjustment unit, a light sensor, a filter holder, an excitation light cut filter, a scattered light transmission unit, a transmission adjustment unit, and a control unit. As seen in plan view, the area occupied by the scattered light transmission unit is arranged on the excitation light cut filter or on the filter holder and is smaller than the area of a fluorescence transmission region as seen in plan view.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: October 22, 2019
    Assignee: Konica Minolta, Inc.
    Inventors: Hideyuki Fujii, Tetsuya Noda, Yukito Nakamura
  • Patent number: 10444179
    Abstract: The present disclosure provides apparatuses and methods for analyzing the presence of a target analyte. The apparatuses and methods of the present disclosure can be operated in a multiplexed format to perform various assays of clinical significance.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: October 15, 2019
    Assignee: MULTERRA BIO, INC.
    Inventors: Kee-Hyun Paik, Kaveh M. Milaninia, Kilian Dill
  • Patent number: 10436699
    Abstract: An analyzing system includes an imaging cytometer having a first imaging section configured to perform an imaging of particles contained in an analyte sample to generate images, the imaging cytometer being configured to analyze the images generated by the first imaging section, and a blood cell analyzing apparatus configured to analyze particles contained in the analyte sample by at least one of an electrical resistance method and an optical analyzing method. One of the imaging cytometer and the blood cell analyzing apparatus has an analyzing section configured to produce a report of an analysis of the analyte sample based on particle information acquired by the imaging cytometer and particle information acquired by the blood cell analyzing apparatus.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: October 8, 2019
    Assignee: NIHON KOHDEN CORPORATION
    Inventor: Yutaka Nagai
  • Patent number: 10439090
    Abstract: A transparent luminescent solar concentrator is provided. In another aspect, a luminescent solar concentrator absorbs outside of visible light and emits outside of visible light. A further aspect of a luminescent solar concentrator employs nanocrystal clusters embedded in a polymeric matrix. In still another aspect, a unique ligand and luminophore host pairing is used for a solar concentrator.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: October 8, 2019
    Assignee: Board of Trustees of Michigan State University
    Inventors: Richard R. Lunt, Yimu Zhao
  • Patent number: 10439078
    Abstract: Provided are a photosensor and a method of operating the same. The photosensor includes a lower electrode, a semiconductor layer, a 2-dimensional material layer, and an upper electrode. Photocurrent generated due to externally radiated light may be operated in a multiple detection mode including a lateral detection mode and a vertical detection mode. The upper electrode may include a plurality of electrode elements, which may be formed of the same conductive material or different conductive materials.
    Type: Grant
    Filed: February 12, 2018
    Date of Patent: October 8, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Heejeong Jeong, Jisoo Kyoung, Changwon Lee, Jinseong Heo
  • Patent number: 10429256
    Abstract: Nanoscale stress-sensing can be used across fields ranging from detection of incipient cracks in structural mechanics to monitoring forces in biological tissues. We demonstrate how tetrapod quantum dots (tQDs) embedded in block-copolymers act as sensors of tensile/compressive stress. Remarkably, tQDs can detect their own composite dispersion and mechanical properties, with a switch in optomechanical response when tQDs are in direct contact. Using experimental characterizations, atomistic simulations and finite-element analyses, we show that under tensile stress, densely-packed tQDs exhibit a photoluminescence peak shifted to higher energies (“blue-shift”) due to volumetric compressive stress in their core; loosely-packed tQDs exhibit a peak shifted to lower energies (“red-shift”) from tensile stress in the core. The stress-shifts result from the tQD's unique branched morphology in which the CdS arms act as antennas that amplify the stress in the CdSe core.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: October 1, 2019
    Assignee: The Regents of the University of California
    Inventors: Shilpa N. Raja, Danylo Zherebetskyy, Siva Wu, Peter Ercius, Andrew C. K. Olson, Paul Alvisatos, Robert O. Ritchie, Sanjay Govindjee
  • Patent number: 10419125
    Abstract: A dynamic gain equalizer (DGE) for an optical communication device and related method which are capable of reducing power variations among wavelength division multiplexing (WDM) signals. The DGE and method use an optical attenuation device configured such that the ratio of pixel gap distance to the channel beam diameter at the point of incident to the optical attenuation device is less than or equal to 0.06. The DGE can produce output signal sets that have ripple increases of less than 0.1 db over the input signal sets.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: September 17, 2019
    Assignee: Molex, LLC
    Inventors: Gongjian Hu, Lifu Gong, Yi Liao, Tian Zhu
  • Patent number: 10415761
    Abstract: An autonomous, permanently illuminating object includes a sheath that defines an interior space in which is disposed a glass capsule containing a gaseous tritium light source. The sheath defines a transparent region. A layer of photoluminescent pigments is disposed between the glass capsule and the transparent region of the sheath.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: September 17, 2019
    Assignee: Smolsys AG
    Inventors: Sandro M. O. L. Schneider, Patrick P. Burkhalter
  • Patent number: 10401293
    Abstract: Provided is a microscope including: a scanner for scanning excitation light; an objective optical system that focuses the excitation light onto a sample and that collects fluorescence generated by the sample; a light-blocking member for transmitting a portion of the collected fluorescence; a detector for detecting the fluorescence; a setting unit that allows types of fluorescence having passed through the light-blocking member to be detected by the detector at different times in two types of positional relationships in which the positional relationship between the position of an opening in the light-blocking member and a focal point of the objective optical system in the sample is set to an optically conjugate positional relationship, in which in-focus fluorescence passes through the light-blocking member, and to an optically nonconjugate positional relationship; and an arithmetic operation unit for calculating the difference between fluorescence signals acquired at different times by the detector.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: September 3, 2019
    Assignee: OLYMPUS CORPORATION
    Inventor: Kentaro Imoto
  • Patent number: 10393658
    Abstract: An analysis apparatus includes a gas chamber for receiving a gas to be analyzed, a source to emit radiation into the chamber. The radiation is to selectively excite molecules of the gas. The apparatus further includes a sensor to detect a physical variable which contains information about a degree of interaction between the radiation and the gas. The source includes a heatable planar radiation element to emit radiation and a housing with a first wall and a second wall which, therebetween, define and immediately delimit a radiation element receptacle chamber that is separated in a fluid-tight manner from the surroundings of the source. At least one of the first or second housing wall is transparent to the electromagnetic radiation that is emittable by the radiation element.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: August 27, 2019
    Assignee: Infineon Technologies AG
    Inventors: Alfons Dehe, Christoph Glacer, David Tumpold
  • Patent number: 10386299
    Abstract: Provided is a fluorescence image acquisition apparatus for acquiring fluorescence images and phase images using optical signals that are modulated at the same frequency and that have different time delays. The fluorescence image acquisition apparatus may include a light source configured to generate, at different time delays, a plurality of optical signals that are modulated at the same frequency, an illuminator configured to control paths of the plurality of modulated optical signals so that the plurality of modulated optical signals are illuminated onto a sample including a plurality of fluorescent materials, a photodetector configured to detect a plurality of fluorescence signals that are emitted from the plurality of fluorescent materials, respectively, and a controller configured to acquire a plurality of fluorescence images and a plurality of phase images from the plurality of detected fluorescence signals.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: August 20, 2019
    Assignee: KOREA BASIC SCIENCE INSTITUTE
    Inventors: Dong Uk Kim, Ki Soo Chang, Geon Hee Kim, Joo Ran Lee
  • Patent number: 10352817
    Abstract: A device and method for geometrically measuring an object, with a base and a carrier device arranged thereon for the object, at least one reference object which can be fixed relative to the base, at least one distance measuring system, by means of which a distance between the reference object and the surface of the object facing the reference object can be determined, and an object holder having an upper side and a lower side, to which the object can be attached, wherein the object holder can be selectively arranged in a first orientation and a second orientation on the carrier device, wherein the distance measuring system and the object holder are movable relative to each other in order to scan the surface of the object, and the object holder has on the upper side thereof and on the lower side thereof respective reference structures.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: July 16, 2019
    Assignee: TAYLOR HOBSON LTD.
    Inventors: Thilo May, Christian Am Weg, Gernot Berger, Ralf Nicolaus, Jurgen Petter
  • Patent number: 10354366
    Abstract: An image processing device includes: an estimation unit configured to estimate a spectral reflectance ratio at each pixel position in a visible light image and a near infrared image in which an object of photographing is photographed, the spectral reflectance ratio indicating a ratio of a spectral reflectance of a visible light wavelength region to a spectral reflectance of a near infrared light wavelength region; and a restoration unit configured to multiply an estimated spectral reflectance ratio by luminance of the near infrared image at each pixel position and generate a restored visible light image.
    Type: Grant
    Filed: January 15, 2016
    Date of Patent: July 16, 2019
    Assignee: NEC CORPORATION
    Inventor: Masato Toda
  • Patent number: 10330679
    Abstract: In this application is described a method for rapidly and accurately identifying B. anthracis in a sample by simultaneously detecting the presence of cell wall antigen and capsule antigen in the same sample culture grown under capsule inducing conditions. Other uses and advantages of the method of the invention are described herein.
    Type: Grant
    Filed: May 14, 2018
    Date of Patent: June 25, 2019
    Assignee: The United States of America, as represented by the Secretary of the Army
    Inventors: Teresa Abshire, Wilson Ribot
  • Patent number: 10307063
    Abstract: An optical measuring device including a light source, a light beam path adjuster, a light detector and a controller is provided. The light source may emit light toward an object in a predetermined progress direction. The light beam path adjuster may be disposed between the light source and the object and may change a progress path of the light emitted from the light source. The light detector may receive the light that is reflected from the object after passing through the light beam path adjuster. The controller may compare a first effective beam path length of the reflected light that the light detector receives with a predetermined target beam path length and control a refractive angle of the light beam path adjuster based on a beam path length difference between the first effective beam path length and the predetermined target beam path length.
    Type: Grant
    Filed: August 16, 2016
    Date of Patent: June 4, 2019
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Seung Jun Lee, Dong Ho Kim, Jung Mok Bae, Eui Seok Shin, Woo Chang Lee
  • Patent number: 10302556
    Abstract: Systems, methods, instruments and devices of the various embodiments enable improved characterization and comparison of the level and species of surface contaminants from photo-induced emission analysis. The various embodiments may provide flexibility for calculating and analyzing the time-dependence of emission efficiencies. Irregular and heterogeneous surfaces, including regionally multiply-connected surface compositions, may be analyzed according to the various embodiments, and the various embodiments include techniques that support specific contaminant identification. Various embodiment focusing techniques may enhance assessment of spatially differential regional analysis of the substrate for more critical applications. The various embodiments may also include differential comparison with reference surfaces, either through differential comparison while scanning, or by comparison to digitally stored responses to known contaminants.
    Type: Grant
    Filed: July 14, 2016
    Date of Patent: May 28, 2019
    Assignee: THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF NASA
    Inventors: William T. Yost, Daniel F. Perey
  • Patent number: 10288862
    Abstract: A SPIM-microscope (Selective Plane Imaging Microscopy) having a y-direction illumination light source and a z-direction detection light camera. An x-scanner generates a sequential light sheet by scanning the illumination light beam in the x-direction. By an illumination optics having a zoom optics that is provided in the beam path of the illumination light beam the focal length of the illumination light beam can be varied.
    Type: Grant
    Filed: June 1, 2015
    Date of Patent: May 14, 2019
    Assignee: Leica Microsystems CMS GmbH
    Inventors: Werner Knebel, Wolfgang Oestreicher
  • Patent number: 10274291
    Abstract: A luminescent archery target enabling target shooting in low light conditions. At least a portion of the target is formed from a material that glows in the dark for long durations, such as a strontium-based luminescent composition. Example target configurations include a non-luminescent core and an outer layer applied over at least a portion of the core, wherein the outer layer includes the luminescent material. The target can be configured as a three-dimensional block, as a model of a game animal, or in other shapes and sizes.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: April 30, 2019
    Assignee: KRYPTOLIGHT TARGETS LLC
    Inventors: Seth Jeremiah Davis, Herman Ray Davis
  • Patent number: 10244964
    Abstract: A method of detecting at least one of analyte in an environment (such as in breath) includes providing a structure including nanostructures in contact with titanium dioxide, applying electromagnetic radiation to the structure for a period of time, measuring at least one response and using the measured response to determine the presence of the analyte in the environment.
    Type: Grant
    Filed: September 6, 2014
    Date of Patent: April 2, 2019
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Alexander Star, Mengning Ding
  • Patent number: 10249781
    Abstract: Disclosed is an apparatus for counting single photons including an edge combiner configured to detect an edge of each of applied clocks using a plurality of Phase-Locked Loops (PLL) to generate a combined signal; a sampling unit configured to sample all events occurring in each SPAD of a single photon detection diode (SPAD) array using an OR tree and an XOR tree; and a calculation unit configured to count the sampled events based on the combined signal to count single photons.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: April 2, 2019
    Assignee: INDUSTRY—ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
    Inventors: Seong-Ook Jung, Jung Hyun Park, Ki Ryong Kim
  • Patent number: 10234389
    Abstract: A method for inspecting an article containing a target material is provided. A sampling position of the article is illuminated by a beam of laser light having a wavelength ?. Illumination focus to a focal point at the sampling position of the article to produce molecular excitation of the target material by simultaneous absorption of n incident photons of the beam of laser light, wherein n is equal to or greater than two. An output light exited from the article is analyzed by a detector, wherein the output light is of a wavelength range between 0.8? and 1.2?.
    Type: Grant
    Filed: January 17, 2017
    Date of Patent: March 19, 2019
    Assignee: CM VISUAL TECHNOLOGY CORPORATION
    Inventors: Wang-Yang Li, Ming-Che Chan, Hsiang-Ning Chen
  • Patent number: 10222316
    Abstract: An imaging flow cytometry apparatus and method which allows registering multiple locations across a cell, and/or across multiple flow channels, in parallel using radio-frequency-tagged emission (FIRE) coupled with a parallel optical detection scheme toward increasing analysis throughput. An optical source is modulated by multiple RF frequencies to produce an optical interrogation beam having a spatially distributed beat frequency. This beam is directed to one or more focused streams of cells whose responsive fluorescence, in different frequencies, is registered in parallel by an optical detector.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: March 5, 2019
    Assignee: The Regents of the University of California
    Inventors: Bahram Jalali, Eric Diebold, Brandon Buckley
  • Patent number: 10184892
    Abstract: A monitoring system configured to receive an on-line sample associated with a process includes a sample chamber positioned to receive the on-line sample and a detector positioned to selectively receive and detect multiple wavelengths of light transmitted through the sample during an absorbance measurement, and emitted by the sample during a fluorescence measurement in response to illumination by each of the at least one excitation wavelength. An optical fiber couples light transmitted through the sample and directs the transmitted light to the multi-channel detector during the absorbance measurement. Optics direct light emitted by the sample during the fluorescence measurement to the detector without passing through any optical fiber. A computer in communication with the detector is configured to correct the fluorescence measurement using the absorbance measurement and determine a sample parameter based on the fluorescence and absorbance measurements of the on-line sample.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: January 22, 2019
    Assignees: HORIBA INSTRUMENTS INCORPORATED, HORIBA ADVANCED TECH CO. LTD.
    Inventors: Adam Matthew Gilmore, Kiichiro Tomioka
  • Patent number: 10180399
    Abstract: Methods and systems are disclosed for extracting an image of a target fluorophore in a biological material, which involve inducing both autofluorescence of the biological material and fluorescence of the fluorophore, acquiring an image arising from both the autofluorescence of the biological material and the fluorophore, and an image arising only from the autofluorescence, subtracting the two images to produce an image representing only the fluorophore, wherein relative intensities of the excitation light used to induce the autofluorescence and the fluorescence are modulated prior to acquiring the images.
    Type: Grant
    Filed: October 31, 2017
    Date of Patent: January 15, 2019
    Assignee: Novadaq Technologies ULC
    Inventors: Eduardo Hiroyuki Moriyama, Chun Ho Sze
  • Patent number: 10166176
    Abstract: Zinc oxide compositions as well as techniques for plasmonic enhancement of absorption in sunscreen applications are provided herein. A method includes selecting one or more metal particles to be used in conjunction with one or more zinc oxide particles in a sunscreen composition, wherein said selecting is based on the plasmon resonance frequency associated with each of the metal particles; and embedding the one or more selected metal particles into each of the one or more zinc oxide particles.
    Type: Grant
    Filed: February 16, 2017
    Date of Patent: January 1, 2019
    Assignee: International Business Machines Corporation
    Inventors: Talia S. Gershon, Yun Seog Lee, Ning Li, Devendra Sadana, Teodor K. Todorov
  • Patent number: 10168310
    Abstract: A system or method for analyzing a sample include an input light source, an excitation light source positioned to receive light from the input light source and to sequentially illuminate the sample with each of a plurality of wavelengths, a fluorescence detector positioned to receive and substantially simultaneously detect multiple wavelengths of light emitted by the sample for each of the plurality of excitation wavelengths, an absorption detector positioned to receive and detect light passing through the sample, and a computer in communication with the excitation light source, the fluorescence detector, and the absorption detector, the computer controlling the excitation light source to sequentially illuminate the sample with each of the plurality of wavelengths while measuring absorption and fluorescence of the sample based on signals received from the fluorescence and absorption detectors.
    Type: Grant
    Filed: December 1, 2014
    Date of Patent: January 1, 2019
    Assignee: HORIBA INSTRUMENTS INCORPORATED
    Inventors: Adam Matthew Gilmore, Xiaomei May Tong