Luminophor Irradiation Patents (Class 250/458.1)
  • Patent number: 12222279
    Abstract: A flowcell device, including a flow pathway and an optical subassembly, has a flowcell body that is continuous with a sample being analyzed and a temperature controlled surface. The flowcell body can be disposed between a thermalplate, actively regulated by a thermoelectric cooler, and an insulating member. The flowcell device can be employed in a bioreactor monitoring system.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: February 11, 2025
    Assignee: Nirrin Technologies, Inc.
    Inventors: Bryan A. Hassell, Aaron Delahanty
  • Patent number: 12211334
    Abstract: A device for verifying a machine-readable security feature of a document of value, having: a transport device configured to transport the document on a transport plane, a radiation emitter that is arranged on a first flat side and emits radiation in the direction towards the first flat side, a sensor that is arranged on the first flat side and is configured to receive at least part of the luminescent radiation, a reflector arranged and configured on the second flat side-so as to at least partly reflect the luminescent radiation of the security feature of the document of value to the sensor, and an evaluation unit.
    Type: Grant
    Filed: February 9, 2022
    Date of Patent: January 28, 2025
    Assignee: CI Tech Sensors AG
    Inventor: Christoph Reinhard
  • Patent number: 12209826
    Abstract: A radiative cooling device can include a reflector positionable to permit operation during daylight hours.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: January 28, 2025
    Assignee: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Marin Soljacic, Evelyn Wang, Yichen Shen, Bikramjit Bhatia, Arny Leroy
  • Patent number: 12152991
    Abstract: The invention provides systems for characterizing a biological sample by analyzing emission of fluorescent light from the biological sample upon excitation and methods for using the same. The system includes a laser source, collection fibers, a demultiplexer and an optical delay device. All references cited herein are incorporated by reference in their entirety as though fully set forth. Unless defined otherwise, technical and scientific terms used herein have the same meaning as commonly understood by one of-ordinary skill in the art in which this invention belongs.
    Type: Grant
    Filed: July 21, 2022
    Date of Patent: November 26, 2024
    Assignee: Cedars-Sinai Medical Center
    Inventors: Pramod Butte, Paul Lapchak, David Scott Kittle
  • Patent number: 12148775
    Abstract: A hyperspectral element includes (1) a multi filter including: a first sub filter through which first wavelength light having a first wavelength passes; and a second sub filter through which second wavelength light having a second wavelength passes, the second wavelength being different from the first wavelength; and (2) a multi detector configured to detect the first wavelength light and the second wavelength light, wherein the first sub filter and the second sub filter may be arranged in series in an optical path of incident light which is incident onto the multi filter.
    Type: Grant
    Filed: October 8, 2021
    Date of Patent: November 19, 2024
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventor: Youngzoon Yoon
  • Patent number: 12140544
    Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.
    Type: Grant
    Filed: April 27, 2023
    Date of Patent: November 12, 2024
    Assignees: Life Technologies Holdings PTE LTD, Life Technologies Corporation
    Inventors: Ming Song Chen, Chee Woei Chong, Wuh Ken Loh, Wern Yuh Foo, Kuan Moon Boo, Norbert Leclerc, Kristina Uhlendorf, Reiner Koellner, Torsten Fuchs, Stefan Breitfelder
  • Patent number: 12111456
    Abstract: The application discloses a method and apparatus for imaging a sample by interferometric scattering microscopy, the method comprising illuminating a sample with at least one coherent light source, the sample being held at a sample location comprising an interface having a refractive index change, illuminating the sample with illuminating radiation to generate a backpropagating signal from the sample comprising light reflected at the interface and light scattered by the sample, splitting the backpropagating signal into first and second signals, modifying the second signal using a modifying element such that the second signal differs from the first signal, directing the first and second signals onto first and second detectors to generate, respectively, first and second images and comparing, by a processor, the first and second images to determine one or more characteristics of the sample.
    Type: Grant
    Filed: October 9, 2020
    Date of Patent: October 8, 2024
    Assignees: Refeyn Ltd, Oxford University Innovation Limited
    Inventors: Matthias Karl Franz Langhorst, Daniel Richard Cole, David John Lehar Graham, Philipp Kukura, Lee Priest
  • Patent number: 12092845
    Abstract: A color conversion film is provided which, upon excitation by blue light, emits green and red light. The color conversion films include at least one red light emitting layer, one green light emitting layer and sandwiched in between at least one inorganic separation layer. The green light emitting layer includes green emitting perovskite crystals.
    Type: Grant
    Filed: April 4, 2023
    Date of Patent: September 17, 2024
    Assignee: Avantama AG
    Inventors: Norman Albert Lüchinger, Deniss Sabani, Fangjian Lin, Sacha Bissig
  • Patent number: 12072480
    Abstract: Devices, systems and methods are described that can be used to develop confocal microscopes with high lateral resolution. One example confocal microscope includes a first dispersion element that receives a light beam and to produce illumination beams with different spectral components, and an objective that receives reflected light upon reflection of the illumination beams from a target. The confocal microscope further includes a second dispersion element that receives the reflected light after propagation through in the objective lens, and a third dispersion element that receives the dispersed light associated with the second dispersion element and provides an output light to a camera lens for focusing onto a detector. The second and the third dispersion elements are positioned such that each point on the detector is conjugate to a corresponding single point on the target. Some applications of the disclosed confocal microscopes include skin disease diagnosis and imaging of freshly-excised tissues.
    Type: Grant
    Filed: January 17, 2020
    Date of Patent: August 27, 2024
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Dongkyun Kang, Cheng Gong
  • Patent number: 12061159
    Abstract: Practical implementation of Particle-Induced X-ray Emission (PIXE) on a focused ion beam apparatus or on a dual-beam apparatus comprising both focused-ion beam and scanning microscopy capabilities is described. Accordingly, an analytical method comprises: directing and focusing a beam of ions comprising a mixture of protons and non-hydrogen ions onto a sample, wherein the kinetic energy of ions of the mixture is not greater than 50 kilo-electron-Volts (keV); and detecting and measuring X-rays that are emitted from the sample in response to the impingement of the protons and non-hydrogen ions onto the sample.
    Type: Grant
    Filed: April 25, 2022
    Date of Patent: August 13, 2024
    Assignee: FEI Company
    Inventors: Daniel Totonjian, Aurelien Philippe Jean Maclou Botman, Milos Toth
  • Patent number: 12035892
    Abstract: An endoscope system includes: a light source including one or more semiconductor light sources; an image pickup apparatus configured to pick up an image of the object irradiated with the illumination light to obtain the image; and a processor. The processor is configured to detect brightness of the image, to change one of a current value and an application period of a current applied to the semiconductor light source when the brightness of the image belongs to a first brightness range, to change the brightness of the image by predetermined processing, to which the image is subjected, when the brightness of the image belongs to a second brightness range, and to change the other of the current value and the application period of the current applied to the semiconductor light source when the brightness of the image belongs to a third brightness range.
    Type: Grant
    Filed: November 17, 2020
    Date of Patent: July 16, 2024
    Assignee: OLYMPUS CORPORATION
    Inventors: Satoshi Tanaka, Yoichiro Sakanoue, Noriko Kohira
  • Patent number: 12017678
    Abstract: An optical system and method for controlling the system, and a self-driving vehicle connected thereto. The optical system includes a housing; a first light source configured to emit light in a first wavelength band; a second light source configured to emit light in a second wavelength band different from the first wavelength band; a dichroic element configured for combining light from the first light source and the second light source into an output light beam to be scanned over a field of view; a scanning unit configured to direct output beam outwardly from the optical system, the scanning unit being disposed in the housing; a controller communicatively coupled with the scanning unit; and at least one sensor communicatively coupled with the controller and configured to sense light reflected off surrounding objects into the optical system.
    Type: Grant
    Filed: September 16, 2021
    Date of Patent: June 25, 2024
    Assignee: Direct Cursus Technology L.L.C
    Inventors: Dmitry Valentinovich Solomentsev, Andrey Viktorovich Golikov, Nikolay Evgenevich Orlov, Vladimir Albertovich Kuznetsov
  • Patent number: 11988604
    Abstract: Imaging a sample that includes phototransformable optical labels (“PTOLs”) with an optical system having a diffraction-limited resolution volume (DLRV), includes providing activation radiation to the PTOLs to activate a statistical subset of the PTOLs. A density of the PTOLs of the activated subset is less than an inverse of the DLRV. Excitation radiation is provided to the activated subset to excite activated PTOLs. Radiation emitted from the activated and excited PTOLs located at different focal planes of the optical system within the sample is detected with the optical system. The preceding steps are repeated one or more times, each time activating a different statistical subset of the plurality of PTOLs. Three-dimensional locations within the sample are determined, with a sub-diffraction-limited accuracy, of the activated and excited PTOLs based on the radiation emitted from the activated and excited PTOLs that is detected from the different focal planes of the optical system.
    Type: Grant
    Filed: May 13, 2021
    Date of Patent: May 21, 2024
    Assignee: Hestzig LLC
    Inventors: Robert Eric Betzig, Harald F. Hess
  • Patent number: 11988632
    Abstract: Embodiments of the present disclosure provide a system for continuous scanning monitoring and analysis based on a discrete three-dimensional fluorescence technology. The system comprises a high-pressure capillary gel electrophoresis mechanism configured to enable passages of different lengths of STR sequence fragments and nucleic acid gene fragments in an energized state; a sampling window unit configured to assemble a plurality of capillary tubes and a plurality of detection optical fibers shared by an excitation light and excited light; and a detection window unit configured to assemble the plurality of detection optical fibers and a fluorescence signal detection unit. The fluorescence signal detection unit is configured to output a plurality of single excitation light sources and obtain fluorescence signals.
    Type: Grant
    Filed: January 4, 2024
    Date of Patent: May 21, 2024
    Assignee: SUZHOU HELMEN PRECISION INSTRUMENTS CO., LTD.
    Inventors: Kai Jiang, Ping Wang, Yawei Tang, Tao Zhang
  • Patent number: 11971355
    Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.
    Type: Grant
    Filed: April 25, 2023
    Date of Patent: April 30, 2024
    Assignee: Sony Group Corporation
    Inventors: Hirokazu Tatsuta, Gakuji Hashimoto, Tetsuro Kuwayama
  • Patent number: 11947097
    Abstract: A bandpass filter for light has variable lower and upper cut-off wavelengths. The bandpass filter comprises an areal long-pass filter defining the variable lower cut-off wavelength and an areal short-pass filter defining the variable upper cut-off wavelength. The long-pass filter has different lower cut-off wavelengths in different first area regions which follow to one another in a first direction, and the short-pass filter has different upper cut-off wavelengths in different second area regions which follow to one another in a second direction. The long-pass filter and the short-pass filter are connected in series and spatially fixed relative to one another. The first direction and the second direction are oriented crosswise to one another.
    Type: Grant
    Filed: April 6, 2021
    Date of Patent: April 2, 2024
    Assignee: ABBERIOR INSTRUMENTS GMBH
    Inventors: Joachim Fischer, Matthias Henrich, Andreas Schoenle, Lars Kastrup
  • Patent number: 11906420
    Abstract: This invention is capable of improving performance of a biochemical analyzer and facilitating the maintenance. A light source includes: a first LED that emits ultraviolet light and a second LED that has a light emission spectrum different from that of the first LED, the first LED and the second LED being disposed in parallel; a reflection surface that is opposite to the first LED and reflects light of the first LED; and a dichroic surface that is opposite to the second LED, reflects light of the first LED, and allows light of the second LED to penetrate.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: February 20, 2024
    Assignee: Hitachi High-Tech Corporation
    Inventors: Yoshifumi Sekiguchi, Shin Imamura, Takahiro Ando, Tomoto Kawamura, Yuya Matsuoka, Sakuichiro Adachi, Yasuhiro Keta, Eiichiro Takada
  • Patent number: 11867897
    Abstract: An insertion assisting instrument has an outer diameter dimension set to satisfy a relationship of xb?<xc? assuming that an insertion assisting instrument is projected on X-Y coordinates such that a point on a circumference where the insertion assisting instrument has a largest outer diameter (that is, a point on an outer periphery of a proximal-end-side tapered surface at a distal end) is set as an origin and the proximal-end-side tapered surface is brought into contact with an X axis, coordinates of a second point B, which is most distal from the X axis on the circumference where the insertion assisting instrument has the largest outer diameter are (xb?, yb?), and coordinates of a third point C, which is most proximal from the X axis on a circumference at the proximal end of the insertion assisting instrument, are (xc?, yc?).
    Type: Grant
    Filed: July 6, 2021
    Date of Patent: January 9, 2024
    Assignee: Evident Corporation
    Inventor: Motoshi Ikeya
  • Patent number: 11870847
    Abstract: Techniques are disclosed for decentralized data flow valuation and deployment in a highly distributed system. For example, a method comprises the following steps performed in a highly distributed system comprising a plurality of gateway nodes, wherein each of the plurality of gateway nodes is operatively coupled to one or more sensors that provide sensor data to the corresponding gateway node. A data flow is obtained at a given gateway node from a decentralized data storage system upon which a plurality of data flows is stored. The data flow is executed at the given gateway node, wherein the data flow is executed on sensor data obtained by the given gateway node from the corresponding one or more sensors. A data flow valuation operation is performed at the given gateway node based on the executed data flow to generate a data flow valuation result.
    Type: Grant
    Filed: January 21, 2019
    Date of Patent: January 9, 2024
    Assignee: EMC IP Holding Company LLC
    Inventor: Stephen J. Todd
  • Patent number: 11867603
    Abstract: A mold sensor is configured with an enclosed chamber in which a nutrient-treated substrate is positioned. The mold sensor includes an optical sensor that is configured to measure optical properties in the enclosed chamber. A controller operates the optical sensor and is programmed to detect a presence of mold growing in the chamber based on the optical properties measured by the optical sensor.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: January 9, 2024
    Assignee: Robert Bosch GmbH
    Inventors: Seow Yuen Yee, Franz Laermer, Christian Peters, Oliver Peters, Robert Duerichen, Ning Wang, Thomas Rocznik
  • Patent number: 11852794
    Abstract: A high-throughput optical sectioning imaging method and imaging system. The method includes: modulating a light beam into a modulated light beam capable of being focused on a focal plane of an objective lens and being defocused on a defocusing plane of the objective lens, the modulated light beam having incompletely identical modulated intensities on the focal plane of the objective lens; imaging, in different rows of pixels, a sample under illumination of the modulated light beam to obtain sample images in the different rows of pixels; obtaining focal plane images of sample images in the different rows of pixels by demodulation of the sample images according to a demodulation algorithm. The system includes a light beam modulation module, an imaging module and a demodulation module.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: December 26, 2023
    Assignee: HUST-SUZHOU INSTITUTE FOR BRAINSMATICS
    Inventors: Qingming Luo, Jing Yuan, Qiuyuan Zhong, Rui Jin, Hui Gong
  • Patent number: 11852537
    Abstract: A flow cytometry measurement system is disclosed which includes a flow chamber configured to flow particles of interest in a flow stream, one or more optical sources configured to excite the particles of interest by an excitation light activated and deactivated according to a pulse train thus causing particles of interest emitting emission light, one or more sensor packages each comprising a plurality of photodetectors configured to receive emission light from the particles of interest and, in response, provide an output voltage signal and an output current signal corresponding to photoelectron response of an incident photon on the one or more sensor packages, and a detector configured to determine successive single molecular decay of the particles of interest, generate an emission pulse associated with each incident photon on the one or more sensor packages, and count the number of emission pulses.
    Type: Grant
    Filed: April 4, 2023
    Date of Patent: December 26, 2023
    Assignee: Miftek Corporation
    Inventors: Masanobu Yamamoto, Keegan Hernandez, J. Paul Robinson, John Jaiber González Murillo
  • Patent number: 11841324
    Abstract: A method for estimating a stimulated emission depletion microscopy (STED) resolution includes generating a first frame representing a reference image from a field-of-view, the reference image having a predetermined reference resolution, and generating at least one second frame representing a STED image from the same field-of-view, the STED image having the STED resolution to be estimated. The at least one second frame is blurred by applying a convolution kernel with at least one fit parameter to the second frame. An optimal value of the at least one fit parameter of the convolution kernel is determined for which a difference between the first frame and the blurred at least one second frame is minimized. The STED resolution is estimated based on the optimal value of the at least one fit parameter and the predetermined reference resolution.
    Type: Grant
    Filed: March 25, 2021
    Date of Patent: December 12, 2023
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventors: Kai Walter, Lars Friedrich
  • Patent number: 11828905
    Abstract: A dual line photodiode array device encapsulates, on a photoelectric sensing element, two columns of photodiode array units having the same specification and performance; the dual line photodiode array device includes a first photodiode array unit and a second photodiode array unit that are arranged parallel to each other and is used for achieving the measurement of particle velocity. The particle velocity may be more accurately measured by means of integrating the two columns of photodiode array units on a single photosensitive element. The dual line photodiode array device may also be applied to the measurement of raindrops and sea spray droplets.
    Type: Grant
    Filed: February 11, 2018
    Date of Patent: November 28, 2023
    Assignee: INSTITUTE OF ATMOSPHERIC PHYSICS, CHINESE ACADEMY OF SCIENCES
    Inventors: Hengchi Lei, Jiatian Chen, Minsong Huang, Xiaoqing Zhang, Shouyin Zheng
  • Patent number: 11816274
    Abstract: The present disclosure relates to a display device, a touch input device, and a touch input system, where the display device comprises: a display unit including a plurality of light emitting areas; a plurality of touch electrodes disposed between the plurality of light emitting areas and configured to sense a touch; a plurality of grid patterns separated from the plurality of touch electrodes in a preset shape or formed integrally with the plurality of touch electrodes; and a plurality of code patterns formed in a preset code shape in some areas of a front surface corresponding to the plurality of touch electrodes, wherein the plurality of grid patterns comprise grid reference points of intersecting grid reference lines, and are respectively formed at positions corresponding to the grid reference points.
    Type: Grant
    Filed: October 4, 2022
    Date of Patent: November 14, 2023
    Assignee: SAMSUNG DISPLAY CO., LTD.
    Inventors: Gi Na Yoo, Ju Yeon Kim, Won Sang Park, Chang Woo Shim, Seong Jun Lee, Dong Hee Choi
  • Patent number: 11764032
    Abstract: Apparatuses for collection of wavelength resolved and angular resolved cathodoluminescence (WRARCL) emitted from a sample exposed to an electron beam (e-beam) or other excitation beams are described. Cathodoluminescence light (CL) may be emitted from a sample at specific angles relative to the excitation beam and analyzed with respect to light-emitting and other optical phenomena. The described embodiments allow collection of WRARCL data more efficiently and with significantly fewer aberrations than existing systems.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: September 19, 2023
    Assignee: Gatan, Inc.
    Inventors: Michael Bertilson, John Andrew Hunt, David J. Stowe
  • Patent number: 11761896
    Abstract: An analyzing system includes a detection area with a transparent window past which an analyte moves and emits or transmits light. One or more polarizing elements receive and polarize the light into respective two or more different polarization components. One or more optical detectors receive the respective two or more polarization components and generate respective at least two signals in response. A processor is coupled to the optical detectors and configured to determine a polarization status of the light from the analyte based on the at least two signals.
    Type: Grant
    Filed: December 8, 2022
    Date of Patent: September 19, 2023
    Assignee: XEROX CORPORATION
    Inventors: Qiushu Chen, Peter Kiesel, Jacob N. Chamoun, Norman Nan Shi, Noble M. Johnson
  • Patent number: 11747268
    Abstract: A method and system for authenticating an item includes irradiating the item, the item including a polymer substrate including a polymer material and a doping material and configured to emit a radiation spectrum having a spectral signature in response to the irradiating, the doping material capable of absorbing or scattering radiation at a specific wavelength to generate the spectral signature, detecting the spectral signature, and determining a code associated with the spectral signature.
    Type: Grant
    Filed: March 1, 2018
    Date of Patent: September 5, 2023
    Assignee: Spectra Systems Corporation
    Inventor: Nabil Lawandy
  • Patent number: 11710232
    Abstract: The present disclosure relates to the field of image processing and discloses an agricultural advisory system (100) comprising a user device (102) and a cloud server (104). The user device (102) captures a digital image of a scene, receives a sensed data corresponding to scene-related and environmental parameters, and transmits the image and the sensed data to the cloud server. The server (104) stores one or more pre-trained prediction models and a three-dimensional HyperIntelliStack which maps red green blue (RGB) pixel values with hyperspectral reflectance values. The server (104) receives the digital images and the sensed data, transforms the received image made of RGB pixel values into a hyperspectral image using the HyperIntelliStack data structure, computes vegetation indices for each pixel of the hyperspectral image to generate a segmented image, and generates at least one advisory for agriculture and allied areas using the segmented image and one or more prediction models.
    Type: Grant
    Filed: May 24, 2021
    Date of Patent: July 25, 2023
    Assignee: RELIANCE INDUSTRIES LIMITED
    Inventors: Rahul Badhwar, Arun Banerjee, Raghuram Lanka, Kenny Paul, Rajesh Nandru, Suraj Chavan, Sushant Kangade, Bhaskar Bhadra
  • Patent number: 11703387
    Abstract: The present invention provides a time-resolved single-photon counting apparatus, including an excitation light source for generating pulsed excitation light, a specimen optics for collecting an optical signal caused by irradiating the pulsed excitation light to a specimen, a photoelectric converter for photoelectrically converting the optical signal to generate an analog single-photon signal, an analog-to-digital (AD) signal converter for sampling the analog single-photon signal to convert the same into a digital single-photon signal, a digital photon-discrimination and timing detector for generating a photon-discrimination signal by discriminating the single-photon property of the digital single-photon signal to count a pulse time point of the digital single-photon signal to generate a delay time signal having delay time information, and a time-signal processor for counting valid single-photon detection events according to the delay time with reference to the photon-discrimination signal.
    Type: Grant
    Filed: January 20, 2020
    Date of Patent: July 18, 2023
    Assignee: KOOKMIN UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION
    Inventor: Sucbei Moon
  • Patent number: 11680905
    Abstract: A biological analysis system can include an excitation module and an emission module. The excitation module can include a collimator element for receiving excitation light from the excitation light source and transmitting collimated excitation light in a first direction, and a plurality of excitation mirrors arrayed along the excitation light path, each excitation mirror disposed at an acute angle relative to the first direction and configured to reflect collimated excitation light along a second direction. The emission module can be positioned to receive excitation light transmitted along the second direction and can include a sample block comprising a plurality of sample receptacles positioned to receive a beam of collimated excitation light, and a plurality of photodetectors configured to receive emission light transmitted from a respective sample receptacle in a direction transverse to the second direction of the excitation light path.
    Type: Grant
    Filed: January 11, 2022
    Date of Patent: June 20, 2023
    Assignees: Life Technologies Holdings PTE LTD, Life Technologies Corporation
    Inventors: Ming Song Chen, Chee Woei Chong, Wuh Ken Loh, Wern Yuh Foo, Kuan Moon Boo, Norbert Leclerc, Kristina Uhlendorf, Reiner Koellner, Torsten Fuchs, Stefan Breitfelder
  • Patent number: 11662316
    Abstract: A fluorescence observation apparatus according to an embodiment of the present technology includes a stage, an excitation section, and a spectroscopic imaging section. The stage is capable of supporting a fluorescently stained pathological specimen. The excitation section irradiates the pathological specimen on the stage with a plurality of line illuminations of different wavelengths, the plurality of line illuminations being a plurality of line illuminations situated on different axes and parallel to a certain-axis direction. The spectroscopic imaging section includes at least one imaging device capable of separately receiving pieces of fluorescence respectively excited with the plurality of line illuminations.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: May 30, 2023
    Assignee: Sony Corporation
    Inventors: Hirokazu Tatsuta, Gakuji Hashimoto, Tetsuro Kuwayama
  • Patent number: 11656447
    Abstract: A microscopy device comprises a continuous or pulsed wave laser light source; a pair of parallel mirrors configured to receive light from the light source and reflect an array of incoherent light sheets; a beam encoder (e.g., frequency modulation reticle, Hadamard basis, random modulation pattern) to segment the array of incoherent light sheets and encode each light sheet with a respective frequency in reciprocal space; a lens configured to direct the encoded light sheets towards a biological sample; and an image capturing device configured to receive a fluorescence signal from the biological sample.
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: May 23, 2023
    Assignee: THE UNIVERSITY OF HONG KONG
    Inventors: Kevin Kin Man Tsia, Yuxuan Ren, Jianglai Wu, Andy Kam Seng Lau, Queenie Tsz Kwan Lai
  • Patent number: 11631024
    Abstract: An apparatus useful for creating and measuring states of an entangled system, comprising a pair of interacting multi-level systems, each of systems comprising a state |g>; a state |r>, and state |r*>. One or more first electromagnetic fields excite a first transition between the ground state |g> and the state |r> to create an entangled system. One or more second electromagnetic fields are tuned between the state |r> and the intermediate state |r*> so that any population of the systems in |r*> are dark to a subsequent detection of a population in the systems in |g>, providing a means to distinguish the entangled system in the state |g> and the entangled system in the state |r>. In one or more examples, the systems comprise neutral Rydberg atoms.
    Type: Grant
    Filed: February 10, 2021
    Date of Patent: April 18, 2023
    Assignee: California Institute of Technology
    Inventors: Manuel Endres, Alexandre Cooper-Roy, Jacob P. Covey, Ivaylo S. Madjarov, Adam L. Shaw, Vladimir Schkolnik, Jason R. Williams, Joonhee Choi
  • Patent number: 11624651
    Abstract: A spectrometer comprises a plurality of isolated optical channels comprising a plurality of isolated optical paths. The isolated optical paths decrease cross-talk among the optical paths and allow the spectrometer to have a decreased length with increased resolution. In many embodiments, the isolated optical paths comprise isolated parallel optical paths that allow the length of the device to be decreased substantially. In many embodiments, each isolated optical path extends from a filter of a filter array, through a lens of a lens array, through a channel of a support array, to a region of a sensor array. Each region of the sensor array comprises a plurality of sensor elements in which a location of the sensor element corresponds to the wavelength of light received based on an angle of light received at the location, the focal length of the lens and the central wavelength of the filter.
    Type: Grant
    Filed: January 21, 2021
    Date of Patent: April 11, 2023
    Assignee: VERIFOOD, LTD.
    Inventors: Damian Goldring, Dror Sharon, Guy Brodetzki, Amit Ruf, Menahem Kaplan, Sagee Rosen, Omer Keilaf, Uri Kinrot, Kai Engelhardt, Ittai Nir
  • Patent number: 11599999
    Abstract: An apparatus, system, and method for fluorescence imaging with stray light reduction is described. The system including a light source to provide a first illumination of a scene to induce fluorescence from the scene, an image sensor to capture a fluorescence image of the scene during the first illumination, and a controller coupled to the light source, the image sensor, and memory that includes instructions that when executed by the controller causes the system to perform operations. The operations including comparing a first color channel value to a second color channel value of a given pixel included in the fluorescence image to identify one or more pixels of the fluorescence image as being affected by stray light. The operations further including generating a stray light image mask based, at least in part, on the one or more pixels of the fluorescence image identified as being affected by the stray light.
    Type: Grant
    Filed: February 3, 2021
    Date of Patent: March 7, 2023
    Assignee: Verily Life Sciences LLC
    Inventors: Brian Anderson, Tamara Troy
  • Patent number: 11575442
    Abstract: A plastic optical fiber communication system includes a light source that emits a first signal having a first wavelength in a visible light spectrum, the first signal being encoded with information at a high data-rate of 0.1 to 10 Gbit/s; a pump laser system that emits a pump laser light having a second wavelength, different from the first wavelength; a perovskite-doped optical fiber excited by the pump laser light to generate an amplified spontaneous emission spectrum that encompasses the first wavelength so as to receive and amplify the first signal for generating an amplified output signal having the first wavelength; and a photodetector optically coupled to the perovskite-doped optical fiber, and configured to receive the amplified output signal at the high data-rate of 0.1 to 10 Gbit/s. The amplified output signal is encoded with the information.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: February 7, 2023
    Assignee: KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Boon Siew Ooi, Chun Hong Kang, Tien Khee Ng, Osman M. Bakr
  • Patent number: 11555991
    Abstract: A method for illuminating samples in microscopic imaging methods, wherein a number m of different wavelengths ?i, with m>I and i=I, . . . , m, is selected for the illumination. For each of the wavelengths ?i a target phase function ??i(x, y, ?i) is predefined, wherein x and y denote spatial coordinates in a plane perpendicular to an optical axis z and each target phase function ??i(x, y, ?i) is effective only for the corresponding wavelength ?i. The target phase functions ??i are predefined depending on the structure of the sample and/or the beam shape and/or illumination light structure to be impressed on the light used for illumination. A total phase mask is then produced which realises all target phase functions ??i(x, y, ?i). This total phase mask is then illuminated simultaneously or successively with coherent light of wavelengths ?i such that the predefined structure of the illumination light is generated in the region of the sample.
    Type: Grant
    Filed: May 24, 2019
    Date of Patent: January 17, 2023
    Assignee: CARL ZEISS MICROSCOPY GMBH
    Inventors: Joerg Siebenmorgen, Ralf Netz
  • Patent number: 11551877
    Abstract: An object of the present invention is to provide a carbonaceous material used for an electric double layer capacitor having a high electrostatic capacity and capable of maintaining the high electrostatic capacity and energy density over a long period and a method for producing the same. The present invention relates to a carbonaceous material having a specific surface area of 1,200 m2/g to 1,800 m2/g according to a BET method, an R-value of 1.2 or more and a G-band half-value width of 70 cm?1 or more according to a Raman spectrum.
    Type: Grant
    Filed: April 21, 2017
    Date of Patent: January 10, 2023
    Assignee: KURARAY CO., LTD.
    Inventors: Shohei Kobayashi, Motomi Matsushima, Seiya Kimachi, Hideharu Iwasaki
  • Patent number: 11536609
    Abstract: The present invention discloses a multi-excitation wavelength spectrometer fluorescence laser radar system, including a multi-wavelength laser emission system, a signal frequency division system and a data storage and display system. The present invention emits lasers with a plurality of wavelengths into the atmosphere simultaneously to alternately excite an organic matter in atmospheric particulate matters and obtain a fluorescence spectrum. The lasers with different wavelengths can excite the same organic matter to obtain different spectra. By analyzing a matrix diagram of each excitation and emission fluorescence spectrum, the present invention effectively explores the features of compositions and concentration of the organic matter in the atmospheric particulate matters.
    Type: Grant
    Filed: January 5, 2021
    Date of Patent: December 27, 2022
    Assignee: LANZHOU UNIVERSITY
    Inventors: Zhongwei Huang, Jianping Huang, Wuren Li, Ze Li, Jianrong Bi, Jinsen Shi
  • Patent number: 11520132
    Abstract: A SPIM-microscope (Selective Plane Imaging Microscopy) and a method of operating the same having a y-direction illumination light source and a z-direction detection light camera. An x-scanner generates a sequential light sheet by scanning the illumination light beam in the x-direction. An electronic zoom is provided that is adapted to change the scanning length in the x-direction independently of a focal length of the illumination light beam and a size of the light sheet in the y-direction and in the z-direction, wherein the number of image pixels in x-direction is maintained unchanged by the electronic zoom independently of the scanning length in x-direction that has been selected.
    Type: Grant
    Filed: April 16, 2019
    Date of Patent: December 6, 2022
    Assignee: Leica Microsystems CMS GmbH
    Inventors: Werner Knebel, Wolfgang Oestreicher
  • Patent number: 11512202
    Abstract: The present invention provides a solid color film, a preparation method thereof and a display device. The solid color film includes a transparent substrate and a solid color material dispersed in the transparent substrate, and the solid color material includes a host structure formed of cucurbituril and a guest structure supported on the host structure and formed by bonding a carboxyl group-containing rhodamine-based dye and an aminoadamantane through a chemical bond, wherein the guest structure is bonded to the host structure through the adamantane to form a host-guest structure.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: November 29, 2022
    Inventor: Bao Zha
  • Patent number: 11516387
    Abstract: Pulsed hyperspectral, fluorescence, and laser mapping imaging without input clock or data transmission clock is disclosed. A system includes an emitter for emitting pulses of electromagnetic radiation and an image sensor comprising a pixel array for sensing reflected electromagnetic radiation. The system includes a plurality of bidirectional data pads and a controller in communication with the image sensor. The system is such that at least a portion of the pulses of electromagnetic radiation emitted by the emitter comprises one or more of: electromagnetic radiation having a wavelength from about 513 nm to about 545 nm, from about 565 nm to about 585 nm, from about 900 nm to about 1000 nm, an excitation wavelength of electromagnetic radiation that causes a reagent to fluoresce, or a laser mapping pattern.
    Type: Grant
    Filed: January 21, 2020
    Date of Patent: November 29, 2022
    Inventors: Joshua D. Talbert, Donald M. Wichern
  • Patent number: 11493423
    Abstract: A mold sensor is configured with an enclosed chamber in which a nutrient-treated substrate is positioned. The mold sensor includes a sensing system that is configured to measure properties of pressure waves within the enclosed chamber. A controller operates the sensing system and is programmed to detect a presence of mold growing in the chamber based on the characteristics of the pressure wave response within the chamber.
    Type: Grant
    Filed: December 12, 2019
    Date of Patent: November 8, 2022
    Assignee: Robert Bosch GmbH
    Inventors: Seow Yuen Yee, Franz Laermer, Thomas Rocznik
  • Patent number: 11428633
    Abstract: The present disclosure relates to systems and methods for cellular imaging and identification through the use of a light sheet flow cytometer. In one implementation, a light sheet flow cytometer may include a light source configured to emit light having one or more wavelengths, at least one optical element configured to form a light sheet from the emitted light, a microfluidic channel configured to hold a sample, and an imaging device. The imaging device may be adapted to forming 3-D images of the sample such that identification tags attached to the sample are visible.
    Type: Grant
    Filed: February 12, 2020
    Date of Patent: August 30, 2022
    Assignee: Verily Life Sciences LLC
    Inventors: Cheng-Hsun Wu, Brian M. Rabkin, Supriyo Sinha, John D. Perreault, Chinmay Belthangady, James Higbie, Seung Ah Lee
  • Patent number: 11423306
    Abstract: In one embodiment, a method of determining tag signals from measured intensities, the measured intensities collected by light sensors in a sensor array directed to a sample surface, the sample surface including pixel areas and holding a plurality of clusters during a sequence of sampling events, each light sensor directed to and measuring intensity from one of the pixel areas during each sampling period includes adjustments for background intensity and crosstalk and taking into account signal decay and phasing/pre-phasing. Coefficients for the adjustments can be determined by gradient descent, using as ground truth base calling by the system being characterized or by using reliable base calling of well-characterized sample run through the system being characterized.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: August 23, 2022
    Assignee: Illumina, Inc.
    Inventor: Emrah Kostem
  • Patent number: 11422347
    Abstract: An optical assembly for scanning excitation radiation and/or manipulation radiation in a laser scanning microscope. The assembly an optical scanning unit as a first focusing device for providing a first pupil plane, a first beam deflecting device, which is made of a first scanner arranged in the first pupil plane, for scanning the excitation radiation and/or manipulation radiation in a first coordinate direction, and a second focusing device for generating a second pupil plane, which is optically conjugated to the first pupil plane. A second beam deflecting device is provided for deflecting the excitation radiation and/or manipulation radiation, said second deflecting device being arranged in the second pupil plane. A third focusing device is provided in order to generate a third pupil plane, optically conjugated to the first pupil plane.
    Type: Grant
    Filed: August 23, 2018
    Date of Patent: August 23, 2022
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Tiemo Anhut, Matthias Wald, Daniel Schwedt, Beate Böhme
  • Patent number: 11385451
    Abstract: A sample imaging device includes a side illumination unit, a two window sample chamber, and refractive index matching. An optically transparent sample holder is in the sample well as is sample immersion fluid. The refractive index matching includes matching of the refractive index of material of a sample to be imaged.
    Type: Grant
    Filed: February 7, 2018
    Date of Patent: July 12, 2022
    Assignee: The Regents of the University of California
    Inventors: Per Niklas Hedde, Leonel Malacrida
  • Patent number: 11386544
    Abstract: An electronics system may include a substrate, an electronic device bonded to the substrate, a plurality of photoluminescent particles disposed on the electronic device, an illuminator, a sensor, and a control module. The illuminator can illuminate the electronic device. The sensor can capture a first set of positions of the photoluminescent particles on the electronic device when the electronic device is not operating under a load and a second set of positions of the photoluminescent particles when the electronic device is operating under a load. The control module can determine thermomechanical stress on the electronic device based at least in part on a difference between the first set of positions and the second set of positions.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: July 12, 2022
    Assignee: TOYOTA MOTOR ENGINEEEING & MANUFACTURING NORTH AMERICA, INC.
    Inventors: Shailesh N. Joshi, Umesh Gandhi, Vishnu Sundaresan, Vijay Venkatesh, Srivatsava Krishnan
  • Patent number: 11380095
    Abstract: A work supporting apparatus includes: a visible light camera (visible light image photographing unit) configured to photograph a visible light image; a far-infrared camera (thermal image photographing unit) configured to photograph a thermal image; a work progress status determining unit configured to determine a work progress status from the visible light image photographed by the visible light camera and the thermal image photographed by the far-infrared camera; and a display configured to display a determination result of the work progress status.
    Type: Grant
    Filed: January 10, 2020
    Date of Patent: July 5, 2022
    Assignee: MAXELL, LTD.
    Inventors: Daisuke Yoshida, Hiroaki Ito