Luminophor Irradiation Patents (Class 250/458.1)
  • Patent number: 11119028
    Abstract: An optical particle sensor comprises at least first and second light sources of different wavelength for sequential operation. An optical detector is used to detect light from the light sources emitted or scattered by particles to be sensed. A current injection compensation signal is also provided which is dependent on which light source of the optical arrangement is in use. The compensation signal means the amplifier does not need to re-settle in response to different background illumination levels associated with the different light sources. In this way, detection signals may be obtained in quick succession from different light sources.
    Type: Grant
    Filed: January 31, 2018
    Date of Patent: September 14, 2021
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventor: Paul Van Der Sluis
  • Patent number: 11112364
    Abstract: A molecular detection device is related. The device includes a carrier, a detector and a control computer. The carrier includes a substrate, a middle layer and a metal layer. The middle layer is sandwiched between the substrate and the middle layer. The detector is configured to detect molecules on a surface of the carrier. The control computer is connected to the detector and configured to analyze a detection result. The middle layer includes a base and a patterned bulge on the base, and the patterned bulge includes a plurality of strip-shaped bulges, the metal layer is on the patterned bulge.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: September 7, 2021
    Assignees: Tsinghua University, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: Ying-Cheng Wang, Yuan-Hao Jin, Qun-Qing Li, Shou-Shan Fan
  • Patent number: 11105743
    Abstract: The present disclosure provides a portable device and method for controlling an alcoholic beverage through an at least partially transparent container. The method includes acquiring a fluorescence spectrum of the beverage through a wall of the container, normalizing a profile of a measured spectrum according to the maximum intensity of a reference spectrum, calculating a resemblance factor between the measured spectrum and the reference spectrum, and determining if the beverage is genuine according to the obtained value of the resemblance factor.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: August 31, 2021
    Assignees: PERNOD RICARD, CNRS—Direction de l'Innovation et des Relations avec les Enterprises (DIRE), UNIVERSITE DE BORDEAUX, Institut Polytechnique de Bordeaux
    Inventors: Pascal Brunerie, Katia Gouret, Benoit Fil, Stephane Verger, Jean-Luc Bruneel, Francois Guillaume, Caroline Bruneel Delhaye
  • Patent number: 11099132
    Abstract: The invention relates to an optical measurement device for a reaction vessel, and a method therefor. An object is to measure the optical state within a reaction vessel in an efficient, rapid, and highly reliable manner, without an expansion of the device scale.
    Type: Grant
    Filed: November 13, 2018
    Date of Patent: August 24, 2021
    Assignee: UNIVERSAL BIO RESEARCH CO., LTD.
    Inventor: Hideji Tajima
  • Patent number: 11099189
    Abstract: A pyrogenicity test assay and method of pyrogen testing that allows for rapid and ultrahigh sensitivity testing of parenteral pharmaceuticals or medical devices that contact blood or cerebrospinal fluid by employing a Limulus Amoebocyte Lysate (LAL) assay utilizing a photonic-crystal biosensor. The photonic-crystal biosensor is capable of determining the presence of endotoxins in a test sample by monitoring shifts in the resonant wavelength of an open microcavity affected by the changes in the refractive index of the analyte solutions used.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: August 24, 2021
    Assignee: Board of Regents, the University of Texas System
    Inventors: Jing Yong Ye, Jonathan D. Scudder
  • Patent number: 11085818
    Abstract: A rapid sensing value estimation circuit and a method thereof are provided. The rapid sensing value estimation circuit includes a first sensing unit, an integration sensing circuit and a rapid estimation circuit. The rapid estimation circuit includes a clock generator, a second counter, a first digital comparator, and an arithmetic module. The clock generator generates a clock signal. The second counter counts the clock signal to generate a second count value. The first digital comparator determines whether the second count value exceeds a first predetermined count value when the first count value increases. The arithmetic module estimates the first count value at an end of an integration time according to a ratio of the second maximum count value to the second count value and the first count value when the second count value exceeding the first predetermined count value, to generate an estimated count value result.
    Type: Grant
    Filed: September 29, 2020
    Date of Patent: August 10, 2021
    Assignee: ANPEC ELECTRONICS CORPORATION
    Inventor: Jia-Hua Hong
  • Patent number: 11067783
    Abstract: A light sheet microscope includes an illumination optical system configured to generate a light sheet in an intermediate image space. A transport optical system, which is telecentric on both sides, is configured to image the light sheet generated in the intermediate image space into a sample and to image a region of the sample illuminated by the light sheet as an intermediate image into the intermediate image space. A detection optical system is configured to image the intermediate image generated in the intermediate image space onto a detector. The optical axes of the illumination optical system, the transport optical system and the detection optical system intersect one another in the intermediate image space. The microscope further includes a scanning element, which is arranged in the transport optical system and through which the light sheet is moveable in the sample transversely to the optical axis of the transport optical system.
    Type: Grant
    Filed: February 21, 2017
    Date of Patent: July 20, 2021
    Assignee: LEICA MICROSYSTEMS CMS GMBH
    Inventor: Christian Schumann
  • Patent number: 11067438
    Abstract: A laser beam profile measurement device includes: a plate-like or block-like fluorescence generation element including an incidence surface on which a laser light is incident and an emission surface from which the laser light is emitted; a light separation element for separating fluorescence from the laser light, the fluorescence generated in the fluorescence generation element and emitted from the emission surface; and an image element for receiving the fluorescence. The fluorescence generation element includes a first film formed on the incidence surface thereof. The first film has a wavelength-to-reflectance characteristic of transmitting a wavelength ?1 of the laser light and reflecting a wavelength ?2 of the fluorescence. The first film has a wavelength-to-reflectance characteristic of transmitting a wavelength ?1 of the laser light and reflecting a wavelength ?2 of the fluorescence.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: July 20, 2021
    Assignee: CANARE ELECTRIC CO., LTD.
    Inventor: Masaki Tsunekane
  • Patent number: 11060983
    Abstract: An evaluation method of a silicon wafer allows non-destructive and non-contact inspection of a slip that affects the electrical properties of semiconductor devices, without being subjected to restrictions of the surface condition of silicon wafers or processing contents as much as possible. The evaluation method of a silicon wafer includes a step of section analysis where a surface of a single crystal silicon wafer after thermal processing is divided by equally-spaced lines into sections with an area of 1 mm2 or more and 25 mm2 or less and the existence of strain in each of the sections is determined based on a depolarization value of polarized infrared light, and a screening step where the wafer is evaluated as non-defective when the number of adjacent sections being determined to have strain by the section analysis step does not exceed a predetermined threshold value.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: July 13, 2021
    Assignee: GLOBALWAFERS JAPAN CO., LTD.
    Inventors: Haruo Sudo, Nobue Araki, Kazuki Okabe, Koji Araki
  • Patent number: 11054307
    Abstract: A spectrometer may include a radiation source having a spark generator, an entrance slit, a dispersive element and a plurality of detectors, and a rotatable sector shutter having an axis of rotation and a trigger unit optically coupled to the sector diaphragm. The axis of rotation of the sector shutter is non-parallel to a connecting line between the source and the entrance slit.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: July 6, 2021
    Assignee: SPECTRO ANALYTICAL INSTRUMENTS GMBH
    Inventors: Heinz-Gerd Joosten, Wolfram Bohle, Rolf Friedrich Frueke
  • Patent number: 11041806
    Abstract: Provided herein are devices, systems, and methods for detection of sensors, such as light-detectable sensors. The devices or systems as described herein may comprise an illumination assembly configured to direct a light to at least a well of a plurality of wells in the array of wells and a detection assembly configured to detect a signal from the well.
    Type: Grant
    Filed: January 10, 2018
    Date of Patent: June 22, 2021
    Assignee: PHOTOSWITCH BIOSCIENCES, INC.
    Inventors: Andrew Blatz, Thomas Lila, Jay Trautman
  • Patent number: 11035765
    Abstract: Provided are methods of preparing a sample for detection by placing the sample on a shrinkable scaffold and then shrinking the scaffold. An exemplary shrinkable scaffold is a thermoplastic substrate.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: June 15, 2021
    Assignee: The Regents of the University of California
    Inventors: Michelle Khine, Himanshu Sharma, Sophia Lin, Jolie McLane Nokes
  • Patent number: 11036039
    Abstract: A microscopy system has a detection system, which is configured to detect light of a first channel in a detection region and convert it to a first fluorescent light signal, to detect light of a second channel in a second detection region and convert it to a first correction signal, and to detect light of a third channel in a third detection region and convert it to a second correction signal. The system further includes a controller, which is configured to determine an approximation value for the spatial distribution of the concentration of the fluorescent dye in an object region using the first fluorescent light signal, the first correction signal, and the second correction signal. A first part of the emission spectrum of the fluorescent dye is detected in the first detection region.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: June 15, 2021
    Assignee: Carl Zeiss Meditec AG
    Inventors: Marco Wilzbach, Christoph Hauger
  • Patent number: 11022539
    Abstract: The current invention relates to the task of masking, i.e. determination of boundaries in an image of biological particles and/or elements or parts of biological particles in image cytometry. Methods for masking of a biological particle or element or region of a biological particle in a sample are provided which include staining a first element or region of the biological particle with a first fluorescent dye, staining a second element or region of the biological particle with a second fluorescent dye, recording an image of the fluorescent light signal emitted from the sample, and determining boundaries of the biological particle or element or region of the biological particle based on the fluorescent light signal in the image.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: June 1, 2021
    Assignee: ChemoMetec A/S
    Inventors: Rune Troelsgaard Pedersen, Søren Kjærulff
  • Patent number: 11016143
    Abstract: An apparatus for testing a wiring circuit includes: a circuit substrate having wirings in the circuit substrate and pads on an upper surface of the circuit substrate and connected to the wirings; an electrode below a lower surface of the circuit substrate; an optical sensor above the upper surface of the circuit substrate and configured to detect a signal emitted from the upper surface of the circuit substrate; and an optical unit above the optical sensor and configured to irradiate light, wherein the optical sensor includes: an optical substrate whose optical characteristics are changed by the signal emitted from the upper surface of the circuit substrate; and a patterned reflective layer on a surface of the optical substrate facing the circuit substrate, the patterned reflective layer having a first region reflecting light incident on the optical substrate and a second region transmitting the light incident on the optical substrate.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: May 25, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Mee-hyun Lim, Sung-yeol Kim, Jae-hong Kim, Taek-jin Kim, Kyung-min Lee
  • Patent number: 11015119
    Abstract: An ultraviolet light-emitting phosphor having excellent degradation resistance and emission intensity is provided. The ultraviolet light-emitting phosphor is a phosphor comprising yttrium element, scandium element, aluminum element and oxygen element, which is excited by irradiation of vacuum ultraviolet rays or electron beams to emit ultraviolet rays.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: May 25, 2021
    Assignee: Dyden Corporation
    Inventor: Kiichiro Egoshi
  • Patent number: 11002664
    Abstract: An optical device for a biological or chemical sensor includes: an absorption cavity configured to receive a biological or chemical medium; an injection waveguide to inject an analysis light beam into the absorption cavity; and an extraction waveguide to extract a measurement light beam, corresponding to the analysis light beam after transit through the absorption cavity. The absorption cavity has a shape of a right cylinder with an elliptical base. One end of the injection waveguide is placed at a first focus of the ellipse and one and of the extraction waveguide is placed at a second focus of the ellipse. A core of the injection waveguide and a core of the extraction waveguide each have a tip-shaped end, with a constant height in a plane parallel to the generatrix of the right cylinder and a tip-shaped cross section in planes parallel to the base of the right cylinder.
    Type: Grant
    Filed: August 3, 2017
    Date of Patent: May 11, 2021
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Salim Boutami, Mathieu Dupoy, Boris Taurel
  • Patent number: 10989662
    Abstract: The present disclosure provides devices and methods enabling the analysis of biomolecules. In some embodiments, the biomolecules may be DNA, RNA, protein, peptide, small molecule, catalyst, precursor, nucleotide, antibodies, or other biomolecules of interest.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: April 27, 2021
    Assignee: Azure Biosystems, Inc.
    Inventors: Diping Che, Zhefu Zhang
  • Patent number: 10980424
    Abstract: An oral care evaluation process may include: illuminating soft oral tissue within an oral cavity with a light source emitting a spectrum of light which induces fluorescence in an organic compound; generating image data for an image of the soft oral tissue while illuminating the soft oral tissue, the image comprising a plurality of pixels; and evaluating oral hygiene using a programmable processor programmed to assess an attribute of each pixel of the image.
    Type: Grant
    Filed: July 11, 2019
    Date of Patent: April 20, 2021
    Assignee: Colgate-Palmolive Company
    Inventors: Michael Pacelli, Hrebesh Molly Subhash, Michael Fitzgerald, Harsh Mahendra Trivedi
  • Patent number: 10973097
    Abstract: A system for generating a light pulse causes fluorescence in an object. The system includes a light emitting diode (“LED”) light source to emit light onto the object. The light source has an operational radiant flux. The system also includes an imaging sensor to sense light emitted due to fluorescence in the object. The system further includes a controller electrically coupled to the light source. The controller is able to drive the light source to produce a pulse of light at a pulse radiant flux. The controller is also able to inhibit the light source after the pulse for a darkness period. The pulse radiant flux of the light produced by the light source is higher than the operational radiant flux of the light source.
    Type: Grant
    Filed: March 27, 2020
    Date of Patent: April 6, 2021
    Assignee: Electronic Theatre Controls, Inc.
    Inventor: Adam Bennette
  • Patent number: 10962755
    Abstract: A compact microscope including an enclosure, a support element, a primary optical support element located within the enclosure and supported by the support element, at least one vibration isolating mount between the support element and the primary optical support element, a sample stage supported on the primary optical support element to support a sample, a return optical system to receive returned light from a sample and transmit returned light to a detection apparatus, wherein the return optical system is mounted on the primary optical support element, and wherein the compact microscope include a at least one of the following elements; a) an objective lens system, b) a temperature-control system, and c) the return optical system being operable to separate returned light into at least a first wavelength band and a second wavelength band.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: March 30, 2021
    Assignee: OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Achillefs Kapanidis, Bo Jing
  • Patent number: 10961572
    Abstract: A thermally conductive receptacle holder includes a plurality of wells that each receive a receptacle. A cross-brace is mounted to a support to exert a force onto an outer surface of a compressive housing such that the compressive housing exerts a force onto the receptacle holder. An optical fiber associated with each well provides optical communication between the receptacle well and an excitation signal source and/or an emission signal detector.
    Type: Grant
    Filed: June 7, 2019
    Date of Patent: March 30, 2021
    Assignee: GEN-PROBE INCORPORATED
    Inventors: David Buse, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore
  • Patent number: 10961587
    Abstract: In certain embodiments, this application discloses methods for detecting lung cancer. The method includes characterization of cells extracted from human sputum, which is a valuable tissue surrogate and source of upper respiratory cells that become cancerous early in 5 the process of lung cancer development. The method includes the staining of extracted cells with fluorescent reporters that produce a specific pattern in the nuclei of labeled cells, which can be made visible by light microscopy. The pattern is relevant to a type of epigenetic coding of DNA known as DNA methylation, which changes in specific cells of the lung during cancer development, in comparison to normal respiratory cells.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: March 30, 2021
    Assignees: Cedars-Sinai Medical Center, The Regents of the University of California, US Govt Department of Veterans Affairs
    Inventors: Jian Tajbakhsh, Fariborz Mortazavi
  • Patent number: 10955342
    Abstract: A light detection device comprises: a flow path section in which a plurality of lines of flow of a plurality of droplets 4 dispersed in oil and moving along a linear line of flow is retained on an array plane; a laser beam irradiation section which introduces a laser beam 3 in a direction in which the plurality of lines of flow are arrayed in the flow path section to irradiate the plurality of lines of flow; and a light detection section which detects emitted light generated from the plurality of lines of flow by the irradiation of the laser beam, from a vertical direction with respect to the array plane. A refractive index of the oil no and a refractive index of the droplets nd have a difference such that ?0.02?nd?no?0.05.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: March 23, 2021
    Assignee: HITACHI, LTD.
    Inventors: Takashi Anazawa, Yoshinobu Kohara, Chihiro Uematsu, Yusuke Goto
  • Patent number: 10952616
    Abstract: A method of fluorescence calibration. An excitation light is provided and incident on an object through an optical probe. The fluorescence light generated from the object is detected. Structural data of the object is acquired, and an optical attenuation property of the object is calculated based on the structural data. The fluorescence intensity is then calibrated based on the optical attenuation property.
    Type: Grant
    Filed: March 28, 2019
    Date of Patent: March 23, 2021
    Assignee: Canon U.S.A., Inc.
    Inventor: Kohei Watanabe
  • Patent number: 10948363
    Abstract: Disclosed is an optical fiber overheat detection testing apparatus including an optical fiber having a first end and a second end, the optical fiber having a predetermined length associated with a predetermined attenuation based on an overheat detection instrument loop. The apparatus includes a first interrupt disposed equidistant between the first end and the second end defining a first half of the optical fiber and a second half of the optical fiber, the first half and the second half having equal length, the first interrupt having a first actuator operable by a first electric current to attenuate light wave traversal of the optical fiber. The apparatus includes a second interrupt disposed on the first half and spaced from the first end at least six tenths of a meter, the second interrupt having a second actuator operable by a second electric current to attenuate light wave traversal of the optical fiber.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: March 16, 2021
    Assignee: KIDDE TECHNOLOGIES, INC.
    Inventors: Darryl J. DeWitt, Lei Liu
  • Patent number: 10939825
    Abstract: Exemplary systems, devices, methods, apparatus and computer-accessible media for providing and/or utilizing optical frequency domain imaging (OFDI) and fluorescence of structures and, e.g., multimodality imaging using OFDI techniques and fluorescence imaging techniques are described. For example, an arrangement can provide at least one electro-magnetic radiation to an anatomical structure. Such exemplary arrangement can include at least one optical core and at least one cladding at least partially surrounding the fiber(s). A region between the optical core(s) and the cladding(s) can have an index that is different from indexes of the optical core(s) and the cladding(s). The arrangement can also include at least one apparatus which is configured to transmit the radiation(s) via the optical core(s) and the cladding(s) to the anatomical structure.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: March 9, 2021
    Assignees: The General Hospital Corporation, Trustees of Boston University
    Inventors: Guillermo J. Tearney, Brett Eugene Bouma, Hongki Yoo, Milen Shishkov, Joseph Gardecki, Roman Shubochkin, Theodore Morse, Farouc Amin Jaffer
  • Patent number: 10928617
    Abstract: A portable imaging system. The imaging system uses perpendicular beams, both low level laser beams at TEM00 Mode and infrared laser beams all beams at a different level, to separate multipliers to provide bodily Fourier Transformed analog signals, gain, and then separate filters to improve signal quality, and a charge-coupled Device (CCD) to convert the analog signals to digital signals. These separate signal sets are then stored, and a program converts the signals to a rotatable, section capable translucent digital image. The imaging medium for the process may be low concentration Indocyanine Green Dye.
    Type: Grant
    Filed: May 20, 2019
    Date of Patent: February 23, 2021
    Assignee: GDH Enterprises, LLC
    Inventor: Gary D. Huffstutler
  • Patent number: 10921453
    Abstract: A LIDAR includes multiple light sources and a Liquid Crystal on Silicon (LCOS) device for controllably redirecting beams from each of the multiple light sources. The same or a different LCOS device can be used to controllably redirect reflected light to each of several corresponding light detectors. The LCOS device can be adjusted on a slower time scale while the light sources can be sequentially activated on a faster time scale. The LCOS device provides for fine steering control of LIDAR beams. The use of multiple light sources and detectors allows for a higher LIDAR scan rate.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: February 16, 2021
    Assignee: HUAWEI TECHNOLOGIES CO., LTD.
    Inventors: Patrick Dumais, Eric Bernier, Mohammad Mehdi Mansouri Rad
  • Patent number: 10914930
    Abstract: A superresolution STED-NSIM apparatus having an epifluorescence architecture utilizing a 2D structured STED pattern having a N.A. less than a N.A. of the microscope objective and no surface plasmon resonance (SPR) effects. A superresolution STED-NSIM imaging method using a fully deterministic imaging processing method, in which a pre-calibrated set of parameters are used to process all image data.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: February 9, 2021
    Assignee: Arizona Board of Regents on Behalf of the University of Arizona
    Inventors: Leilei Peng, Yu Li, Han Zhang
  • Patent number: 10910425
    Abstract: A solid-state image sensor including a semiconductor layer having a light incident side, a support substrate positioned on an opposite side of the light incident side of the semiconductor layer, photoelectric conversion elements formed two-dimensionally in the semiconductor layer, light reflection structures formed on a surface of the support substrate which faces toward the semiconductor layer, and positioned such that the light reflection structures face the photoelectric conversion elements, respectively, and an interlayer insulating layer formed between adjacent ones of the light reflection structures. The light reflection structures include a light transmission layer and a reflective metal that covers a surface of the light transmission layer opposite to a surface facing the semiconductor layer, and the reflective metal has a concave curved surface facing the photoelectric conversion elements.
    Type: Grant
    Filed: June 5, 2019
    Date of Patent: February 2, 2021
    Assignee: TOPPAN PRINTING CO., LTD.
    Inventors: Kazuto Yamamoto, Yo Sakata
  • Patent number: 10890487
    Abstract: An integrated polarization interferometer includes a polarization beam splitter for separating incident complex waves, a first mirror attached to a first surface of the polarization beam splitter, for reflecting a first polarization transmitted through the polarization beam splitter to the polarization beam splitter, and a second mirror attached to a second surface of the polarization beam splitter, for reflecting a second polarization transmitted through the polarization beam splitter to the polarization beam splitter. Accordingly, it is possible to measure dynamic spectroscopic polarization phenomenon with extremely high robustness disturbances due to an external vibration and the like by using the integrated polarization interferometer, thereby improving measurement repeatability and accuracy of measurement.
    Type: Grant
    Filed: January 26, 2017
    Date of Patent: January 12, 2021
    Assignee: INDUSTRIAL COOPERATION FONDATION CHONBUK NATIONAL UNIVERSITY
    Inventor: Dae Suk Kim
  • Patent number: 10891790
    Abstract: Methods and systems for alignment of a subject for medical imaging are disclosed, and involve providing a reference image of an anatomical region of the subject, the anatomical region comprising a target tissue, processing the reference image to generate an alignment reference image, displaying the alignment reference image concurrently with real-time video of the anatomical region, and aligning the real-time video with the alignment reference image to overlay the real-time video with the alignment reference image. Following such alignment, the subject may be imaged using, for example, fluorescence imaging, wherein the fluorescence imaging may be performed by an image acquisition assembly aligned in accordance with the alignment.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: January 12, 2021
    Assignee: Stryker European Operations Limited
    Inventors: Jorgen Walle-Jensen, Lina Gurevich, Gregory Vincent Browne
  • Patent number: 10890528
    Abstract: Provided are a fluorescent testing system, a molecular testing method, and a fluorescent testing method that can avoid enlargement and complication. A fluorescent testing system (1) includes: an excitation light source (23) that radiates excitation light (L1) to protein to which a fluorescent probe is added; a silicon integrated circuit (10) including a photon detection unit (13) that detects light by a photodiode (12); a holding layer (30) including a microwell (31) that is provided above the photodiode (12) and holds the protein to which the fluorescent probe is added; and a control unit (24) that causes the excitation light source (23) to radiate the excitation light (L1) to the protein which. is held and to which the fluorescent probe is added and causes the photon detection unit (13), after extinguishment of the excitation light (L1), to detect fluorescence emitted from the protein to which the fluorescent probe is added.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: January 12, 2021
    Assignees: SHARP KABUSHIKI KAISHA, The University of Tokyo
    Inventors: Kunihiko Iizuka, Yoshihisa Fujimoto, Soo-Hyeon Kim, Teruo Fujii
  • Patent number: 10883941
    Abstract: In an example implementation, a method includes illuminating a wafer with excitation light having a wavelength and intensity sufficient to induce photoluminescence in the wafer. The method also includes detecting photoluminescence emitted from a portion of the wafer in response to the illumination, and detecting excitation light reflected from the portion of the wafer. The method also includes comparing the photoluminescence emitted from the portion of the wafer and the excitation light reflected from the portion of the wafer, and identifying one or more defects in the wafer based on the comparison.
    Type: Grant
    Filed: June 20, 2018
    Date of Patent: January 5, 2021
    Assignee: SEMILAB Semiconductor Physics Laboratory Co., Ltd.
    Inventors: Zoltan Tamas Kiss, Laszlo Dudas, Zsolt Kovacs, Imre Lajtos, Gyorgy Nadudvari, Nicolas Laurent, Lubomir L. Jastrzebski
  • Patent number: 10883931
    Abstract: Provided are an optical measuring instrument, a flow cytometer, and a radiation counter which reduces a size and a weight of a photodetector, and enables detection of weak pulsed light with a high degree of accuracy and at a high speed. A laser beam source irradiates a specimen to be measured with a laser beam and generates a light pulse of intensity corresponding to the irradiation. An imaging element provided with a pixel including a photoelectric conversion element and an amplification element which sequentially accumulates charges subjected to photoelectric conversion by the photoelectric conversion element for a predetermined period and outputs a voltage as a pixel signal according to an accumulated charge amount after the accumulation is completed through the amplification element, and detects a light amount of the light pulse on the basis of a pixel signals of a pixel group.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: January 5, 2021
    Assignee: SONY CORPORATION
    Inventors: Toshiyuki Nishihara, Kenichi Okumura
  • Patent number: 10874062
    Abstract: First beam source radiates a near infrared reference beam of 905 nm, in which light tends not to be absorbed in water toward a leaf of a plant. Second beam source radiates a near infrared measuring beam of 1550 nm, in which light tends to be absorbed in water toward the leaf of the plant. Threshold level setter/water content index detector calculates a water content index of one leaf as a total sum ? Ln(I905/I1550) of the reflection intensity ratio. Controller displays a graph representing a total sum of water content of the leaf and a pixel average value as a time-transition of the water content contained in the plant from the start of the measurement period on a UI screen of a monitor. Viewed from the first and second beam sources, a white reference substrate covering a back surface of the leaf is disposed on the leaf of the plant.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: December 29, 2020
    Assignee: PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD.
    Inventors: Takeshi Fujiyama, Yuuji Terashima
  • Patent number: 10871480
    Abstract: A multi-sensor device comprises a housing containing multiple sensor modules for capturing and transmitting sensor data for plants in a crop. A control unit within the housing is operable to control the sensor modules, and a communications interface is connected to the control unit for transmitting data from said plurality of sensor modules. The sensor modules can include a physiological sensor, a surface analysis sensor, and chemical sensor. The multi-sensor device can be used as a hand-held device or mounted to a mobile platform for use in an automated crop monitoring system.
    Type: Grant
    Filed: February 6, 2019
    Date of Patent: December 22, 2020
    Assignee: Ecoation Innovative Solutions Inc.
    Inventors: Saber Miresmailli, Murray B. Isman, Maryam Antikchi
  • Patent number: 10856391
    Abstract: A method to correct signal light intensities measured by a detector of a detection unit in a laboratory instrument is presented. The detection unit comprises a light source, a sample plane comprising a sample holder configured to hold at least one sample vessel comprising a test sample to be illuminated, a reference light sensor, and the detector. Based on a basic light intensity of a newly manufactured light source and an initial light intensity measured by the reference light sensor the sensitivity of the reference light sensor can be determined. And signal light intensities measured by the detector can be corrected based on the determined sensitivity and subsequently measured reference light intensities of the reference light sensor in order to generate comparable test results.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: December 1, 2020
    Assignee: Roche Molecular Systems, Inc.
    Inventors: Patrick Waser, Florian Betschart
  • Patent number: 10845363
    Abstract: The present invention recognizes that current clinical laboratory testing methods for multiparametric single cell analysis are limited to analysis of intact live cells, and are insufficient for identification of signaling activation profile defining certain cell types, including but not limited to neoplastic and immunologically activated cell subsets. One aspect of the present invention generally relates to marker selection in panels to include proteins routinely assessed in standard FCM, while preferably also incorporating markers for surface receptor proteins within activated signaling cascades.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: November 24, 2020
    Assignee: DeePath Medical Diagnostics, Inc.
    Inventor: Jita De
  • Patent number: 10845583
    Abstract: A scanning microscope includes a scanning unit that causes irradiation light emitted by a light source to scan a sample, an optical system that guides the emitted light that has passed through the scanning unit to the sample, an isolation unit that includes a transmissive portion that enables the irradiation light to pass the transmissive portion and a reflective portion that reflects at least some of light that is included in emitted light generated from the sample as a result of the irradiation light being radiated to the sample and that has passed through the optical system and the scanning unit, and a detection unit that detects the emitted light that has passed through the isolation unit. The isolation unit is disposed in an optical path of the irradiation light between the light source and the scanning unit.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: November 24, 2020
    Assignee: Canon Kabushiki Kaisha
    Inventors: Naoki Kohara, Akira Yamamoto
  • Patent number: 10845311
    Abstract: A fluorescence lifetime measurement apparatus according to an embodiment of the present invention includes an illumination light generation unit configured to generate illumination light, a fluorescence photon detection unit configured to collect a fluorescence signal of fluorescence photons generated by illuminating at least one or more samples including fluorescent molecules with the illumination light; and a measurement unit configured to compute a fluorescence lifetime by applying a least square method to a simulation function and a function of the fluorescence signal.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: November 24, 2020
    Assignees: YONSEI UNIVERSITY INDUSTRY FOUNDATION (YONSEI UIF), INTEKPLUS CO., LTD.
    Inventors: Dug Young Kim, Won Sang Hwang, Dong Eun Kim, Min Gu Kang
  • Patent number: 10835193
    Abstract: A source grating structure (G0) for interferometric X-ray imaging cable of generating a non-uniform intensity profile behind a surface (S) of the grating structure when exposed to X-ray radiation.
    Type: Grant
    Filed: August 30, 2017
    Date of Patent: November 17, 2020
    Assignee: KONINKLIJKE PHILIPS N.V.
    Inventors: Thomas Koehler, Roland Proksa
  • Patent number: 10833901
    Abstract: A transmitter and receiver for performing a signal select algorithm are provided. A transmitter for providing a signal on a line to be located includes at least one direct digital synthesizer, the direct digital synthesizer producing two component frequencies in response to an input square wave signal; and a feedback loop providing the input square wave.
    Type: Grant
    Filed: October 17, 2016
    Date of Patent: November 10, 2020
    Assignee: Metrotech Corporation
    Inventors: Stephen John Petherick, George Mainescu, Ion Dracea, Razvan Gabriel Stefanoiu, John Mark Royle
  • Patent number: 10831026
    Abstract: A retina scanning type display apparatus includes a scanning portion, a deflection member, and a light flux diameter expanding element. An incidence angle range in a first incidence direction with respect to an eye from the deflection member is broader than an incidence angle range in a second incidence direction, and, in the light flux diameter expanding element, an expanding magnification of light flux diameter in a first expanding direction, which corresponds to the first incidence direction, is greater than an expanding magnification of light flux diameter in a second expanding direction, which corresponds to the second incidence direction. In addition, in the scanning mirror, a width in a first scanning direction, which corresponds to the first expanding direction, is narrower than a width in a second scanning direction, which corresponds to the second expanding direction.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: November 10, 2020
    Assignee: SEIKO EPSON CORPORATION
    Inventor: Takashi Takeda
  • Patent number: 10823952
    Abstract: An instrument for scanning a specimen on a specimen holder. The instrument includes a scanning stage for supporting the specimen and a detector having a plurality of pixels. The scanning stage and the detector are movable relative to each other to move the specimen in a scan direction during a scan, and at least some of the pixels of the detector are operable to collect light inside the specimen during the scan and generate corresponding image data. The instrument also includes a processor operable to perform MSIA on the image data and to generate two or more strip images. Each strip image has a different effective exposure. The processor combines the two or more strip images to generate an increased dynamic range (IDR) image of the specimen.
    Type: Grant
    Filed: June 22, 2018
    Date of Patent: November 3, 2020
    Assignee: HURON TECHNOLOGIES INTERNATIONAL INC.
    Inventor: Arthur Edward Dixon
  • Patent number: 10823618
    Abstract: A method includes capturing an image, and performing region detection on the captured image. The region detection includes identifying an object represented in the captured image. The method further includes detecting emissivity of the identified object and determining the temperature of the object based on the detected emissivity of the object.
    Type: Grant
    Filed: January 25, 2018
    Date of Patent: November 3, 2020
    Assignee: General Electric Company
    Inventors: Guanghua Wang, Bernard Bewlay
  • Patent number: 10821762
    Abstract: An example disclosed media processing device includes an image processing unit; a first optical registration sensor; and a second optical registration sensor spaced apart from the first optical registration sensor along a first axis by a first distance associated with a gap between media units on a web.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: November 3, 2020
    Assignee: Zebra Technologies Corporation
    Inventors: Clive Hohberger, David Womack, Bruce N. Alleshouse, James Clark, Wolfgang Strobel
  • Patent number: 10809216
    Abstract: The present description provides a gas sensor, a method for manufacturing the same and a detection device. The gas sensor includes: an insulation substrate, a gas sensitive element, a first electrode and a second electrode. The gas sensitive element is disposed on the insulation substrate and has a three-dimensional nano network structure. The first electrode and the second electrode are located on opposite sides of the gas sensitive element.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: October 20, 2020
    Assignee: BOE TECHNOLOGY GROUP CO., LTD.
    Inventor: Shengguang Ban
  • Patent number: 10808170
    Abstract: The present invention relates to formulations for the preparation of organic electronic devices (OLEDs) which comprise at least one specific ester solvent containing a non aromatic cycle and at least one organic functional material selected from organic conductors, organic semiconductors, organic fluorescent compounds, organic phosphorescent compounds, organic light-absorbent compounds, organic light-sensitive compounds, organic photosensitisation agents and other organic photoactive compounds, selected from organometallic complexes of transition metals, rare earths, lanthanides and actinides.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: October 20, 2020
    Assignee: Merck Patent GmbH
    Inventors: Gaëlle Béalle, Christoph Leonhard, Hsin-Rong Tseng, Irina Martynova, Aurélie Ludemann