Luminophor Irradiation Patents (Class 250/458.1)
  • Patent number: 10660977
    Abstract: The present invention suppresses the strength reduction or degeneration of a tissue after the tissue is dried and/or sterilized, for the tissue comprising biological components and the like. Specifically, biological tissue is immersed in a trehalose solution and shaken, thereby impregnating the biological tissue with the trehalose solution. The trehalose solution used here is one obtained by dissolving trehalose in a phosphate buffered saline, the concentration of trehalose being preferably in the range of 20 wt % to 35 wt %. Thereafter, the biological tissue is dried to remove moisture in the biological tissue, and sterilized with ethylene oxide gas.
    Type: Grant
    Filed: April 1, 2013
    Date of Patent: May 26, 2020
    Assignee: WASEDA UNIVERSITY
    Inventors: Kiyotaka Iwasaki, Mitsuo Umezu
  • Patent number: 10662403
    Abstract: The present disclosure relates to a method for attaching, detecting and retrieving a single cell on a manipulation medium comprising the steps of: attaching the single cell onto the manipulation medium by applying a carrier liquid; partially drying out the carrier liquid; detecting a property of the single cell by rotating the manipulation medium and scanning a light beam over the manipulation medium; loosening the single cell from the manipulation medium without damaging the single cell by manipulating the single cell with an instrument; and retrieving the single cell from the manipulation medium by aspirating the single cell into a tube, wherein the carrier liquid is dried out to a degree corresponding to that the single cell does not move during the rotation of the manipulation medium and that the single cell can be loosened by the instrument without damaging the single cell. The disclosure further relates to an apparatus for detection and manipulation of one or more object(s).
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: May 26, 2020
    Assignee: CytoTrack ApS
    Inventors: Tom Hede Markussen, Lars Ulrik Nielsen, Robert Naumovski, Anders Skærlund Frandsen, Henrik Stender
  • Patent number: 10664065
    Abstract: A touch sensing apparatus includes at least one conductive sensing element and a reading device. The conductive sensing element includes a substrate and a conductive sensing layer. The conductive sensing layer is disposed on at least one surface of the substrate. The conductive sensing layer includes a plurality of conductive sensing units and a plurality of transparent conductive wires. An orientation distribution of the conductive sensing units is by a coordinate encoding method to constitute a coding pattern. The coding pattern includes coordinate information. The reading device is actuated on the conductive sensing layer, senses and decodes the coding pattern to analyze the coordinate information. The touch sensing apparatus can perform a digital writing and recording without power supply.
    Type: Grant
    Filed: June 5, 2018
    Date of Patent: May 26, 2020
    Assignee: CHI HSIANG OPTICS CO., LTD.
    Inventor: Po Hung Yao
  • Patent number: 10656401
    Abstract: An optical apparatus includes a first optical element and a second optical element capable of separating incident light according to a wavelength of the incident light. The first optical element includes a first separation section having first optical characteristics for reflecting light in a first wavelength band, transmitting light in a second wavelength band, and partially transmitting and partially reflecting light in a third wavelength band. The second optical element includes a second separation section having second optical characteristics for separating incident light that is incident in two wavelength bands including the first wavelength band or the second wavelength band and the third wavelength band into the light in the first wavelength band or the light in the second wavelength band and the light in the third wavelength band according to the wavelength.
    Type: Grant
    Filed: December 8, 2014
    Date of Patent: May 19, 2020
    Assignee: NIKON CORPORATION
    Inventors: Susumu Mori, Tomoya Saito
  • Patent number: 10638076
    Abstract: A sensing apparatus adapted to detect samples is provided. The sensing apparatus includes a light source, a light-penetrating medium, a metal thin film, and a plurality of sensors. The light source is adapted to provide a light beam. The light-penetrating medium has an optical surface. The metal thin film is disposed on the optical surface of the light-penetrating medium. The samples are adapted to be placed on the metal thin film. After the light beam enters the light-penetrating medium from a side away from the optical surface, the light beam is adapted to be totally internally reflected at the optical surface, such that surface plasmon resonance occurs at a surface of the metal thin film to excite the samples. The samples are adapted to emit signal light beams after being excited. The plurality of sensors are adapted to sense the signal light beams. The metal thin film is disposed between the plurality of sensors and the light-penetrating medium.
    Type: Grant
    Filed: June 4, 2019
    Date of Patent: April 28, 2020
    Assignee: GenOptics Precision Biotechnologies Inc.
    Inventor: Teng-Chien Yu
  • Patent number: 10620175
    Abstract: A method for determining chlorophyll content of a plant comprises capturing a first image comprising light transmitted through a leaf of a plant; capturing a second image comprising light reflected from the leaf of the plant; estimating, from a plurality of pixels in the first image, a transmissive chlorophyll concentration value of the leaf; estimating a reflectance chlorophyll concentration value for the leaf from a plurality of pixels in the second image using bidirectional reflectance parameters for which a variance of the reflectance chlorophyll concentration value across the plurality of pixels in the second image is reduced; and determining an estimated chlorophyll concentration value for the plant based at least on the transmissive chlorophyll concentration value and the reflectance chlorophyll concentration value.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: April 14, 2020
    Assignee: RAYTHEON COMPANY
    Inventors: Darrell L. Young, Charlotte DeKeyrel, Michael Henry Lewis
  • Patent number: 10605731
    Abstract: Disclosed is a fluorescence image analyzing apparatus including a light source that emits light to a sample including a plurality of cells labeled with a fluorescent dye at a target site, an imaging unit that captures a fluorescence image of each of the cells that emit fluorescence by being irradiated with the light, a processing unit that processes the fluorescence image captured by the imaging unit, and a display unit that displays the fluorescence image processed by the processing unit. The processing unit performs an extraction process of extracting, for each cell, a plurality of bright spots in the fluorescence image including the target site, a changing process of changing a pixel value of each of the plurality of extracted bright spots based on the pixel value of each bright spot, and a display process of displaying the fluorescence image whose pixel value is changed on the display unit.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: March 31, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Shohei Matsumoto, Shruti Sharma
  • Patent number: 10605826
    Abstract: A calibration apparatus for a tip-enhanced Raman microscope includes a substrate; a two-dimensional Raman scatterer that is mounted on an upper surface of the substrate; and a well-defined topographic structure that is formed at the upper surface of the substrate. The topographic structure may include convex geometric shapes such as triangles and squares arranged in one or more periodic lattices. Calibration is via adjusting a focal length of a laser beam until a signal from a spectrometer repeatedly exhibits a stepped response when a focal point of the laser beam traverses an edge of a two-dimensional Raman scatterer, then adjusting the relative lateral positions of a scanning probe microscope probe tip and the focal point until the signal from the spectrometer and a signal from the scanning probe microscope repeatedly change within an acceptable time delay while the focal point and the probe tip traverse edges of the topographic structure.
    Type: Grant
    Filed: June 17, 2018
    Date of Patent: March 31, 2020
    Assignee: International Business Machines Corporation
    Inventors: Michael Engel, Mathias Steiner, Ado Jorio de Vasconcelos, Cassiano Rabelo, Luiz Gustavo Cancado, Hudson Miranda
  • Patent number: 10605658
    Abstract: A spectrometer includes a light conduit configured to align scattered light scattered in a target by light output from a light source into a collimated beam, and a beam block configured to restrict an angle of the scattered light and detect the scattered light via the light conduit or the beam block through a filter array and a detector, thereby achieving miniaturization in a pen type or a flat plate shape while maintaining a spectral characteristic.
    Type: Grant
    Filed: March 26, 2018
    Date of Patent: March 31, 2020
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Youngzoon Yoon, Hyochul Kim, Younggeun Roh
  • Patent number: 10598597
    Abstract: In the systems and methods of the present invention a multifocal multiphoton imaging system has a signal to noise ratio (SNR) that is reduced by over an order of magnitude at imaging depth equal to twice the mean free path scattering length of the specimen. An MMM system based on an area detector such as a multianode photomultiplier tube (MAPMT) that is optimized for high-speed tissue imaging. The specimen is raster-scanned with an array of excitation light beams. The emission photons from the array of excitation foci are collected simultaneously by a MAPMT and the signals from each anode are detected using high sensitivity, low noise single photon counting circuits. An image is formed by the temporal encoding of the integrated signal with a raster scanning pattern. A deconvolution procedure taking account of the spatial distribution and the raster temporal encoding of collected photons can be used to improve decay coefficient.
    Type: Grant
    Filed: November 16, 2017
    Date of Patent: March 24, 2020
    Assignee: Massachusetts Institute of Technology
    Inventors: Karsten Bahlman, Ki-Hean Kim, Timothy Ragan, Peter T. C. So
  • Patent number: 10595770
    Abstract: A multiphoton microscope based on two-photon excited fluorescence and second-harmonic generation that images FOVs of about 0.8 mm2 (without stitching adjacent FOVs) at speeds of 10 frames/second (800×800 pixels) with lateral and axial resolutions of 0.5 ?m and 2.5 ?m, respectively. The scan head of the instrument includes a fast galvanometric scanner, relay optics, a beam expander and a high NA objective lens. The system is based on a 25×, 1.05 NA water immersion lens, which features a long working distance of 1 mm. A proper tailoring of the beam expander, which consists of the scan and tube lens elements, enables scaling of the FOV. The system and method also include a flat wavefront of the beam, minimum field curvature, and suppressed spherical aberrations. All aberrations in focus are below the Marechal criterion of 0.07? rms for diffraction-limited performance.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: March 24, 2020
    Assignee: The Regents of the University of California
    Inventors: Mihaela Balu, Eric O. Potma, Bruce J. Tromberg, Hideharu Mikami
  • Patent number: 10592745
    Abstract: A method for removing foreign matter from an agricultural product stream of a manufacturing process. The method includes conveying a product stream past an inspection station; scanning a region of the agricultural product stream as it passes the inspection station using at least one light source of a single or different wavelengths; generating hyperspectral images from the scanned region; determining a spectral fingerprint for the agricultural product stream from the hyperspectral images; comparing the spectral fingerprint obtained in step (c) to a spectral fingerprint database containing a plurality of fingerprints using a computer processor to determine whether foreign matter is present and, if present, generating a signal in response thereto; and removing a portion of the conveyed product stream in response to the signal. A system for detecting foreign matter within an agricultural product stream is also provided.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: March 17, 2020
    Assignee: Altria Client Services LLC
    Inventors: Henry M. Dante, Samuel Timothy Henry, Seetharama C. Deevi
  • Patent number: 10585032
    Abstract: A urine analysis system according to an embodiment includes: a testing apparatus that measures particles included in a urine sample according to a flow cytometry method; an image capturing apparatus that captures images of particles in the urine sample to acquire particle images; and a management apparatus that receives a measurement result obtained by the testing apparatus and the particle images acquired by the image capturing apparatus. The management apparatus generates an order to capture an image of the urine sample based on the measurement result obtained by the testing apparatus. The image capturing apparatus executes the image capturing processing of the particles in the urine sample for which the image capturing order has been generated by the management apparatus, and transmits the acquired particle images to the management apparatus.
    Type: Grant
    Filed: September 26, 2017
    Date of Patent: March 10, 2020
    Assignee: SYSMEX CORPORATION
    Inventors: Masakazu Fukuda, Masamichi Tanaka, Yousuke Tanaka
  • Patent number: 10585065
    Abstract: Techniques are described for collecting information regarding the presence or absence of a material of interest in an environment and associating the presence or absence of the material of interest with additional data associated with the environment. In embodiments, the additional data is collected and associated with one or more windows identified for the materials of interest. A method includes initiating sample detection in an environment. The method also includes receiving an indication associated with at least one of a presence or an absence of a material of interest in the environment. The method also includes associating the indication with a time stamp furnished by a clock. The method further includes initiating collection of additional data associated with the environment. The additional data is associated with a second time stamp furnished by the clock. The method also includes associating the indication with the additional data in a window.
    Type: Grant
    Filed: October 10, 2013
    Date of Patent: March 10, 2020
    Assignee: Smiths Detection-Watford Limited
    Inventor: Timothy C. Kirk
  • Patent number: 10578815
    Abstract: An optical amplifier is provided in which radiation levels experienced by an optical fiber are minimized. A sealed enclosure houses an optical fiber. An input optical signal enters on end of the fiber and an amplified output optical signal exits the other end of the optical fiber. Small particles embedded with a gas fill the interior of the enclosure. An optical pump supplies an amplification laser beam coupled to one of the ends of the optical fiber. Due to energy supplied by the amplification laser beam, the input optical signal is amplified upon exiting the optical fiber. At least a portion of the gas embedded in the small particles is released inside the enclosure when the small particles are subjected to heat to provide a gaseous interior in the enclosure that minimizes radiation levels experienced by the optical fiber due to external radiation.
    Type: Grant
    Filed: August 8, 2019
    Date of Patent: March 3, 2020
    Assignee: NORTHROP GRUMMAN SYSTEMS CORPORATION
    Inventor: Ge Wang
  • Patent number: 10579576
    Abstract: Forwarding devices and corresponding methods are provided in which a plurality of input data streams are distributed among a plurality of output data streams on the basis of synchronization marking. One example method of forwarding data includes receiving a plurality of input data streams, where at least some of the input data streams include synchronization markers indicating which data of the input data streams are to be output synchronously, in one or more common time segments. Further included in the method is distributing the data to be output synchronously among a plurality of output data streams on the basis of the synchronization markers. The distributing is carried out in such a way that data which, according to the synchronization markers, are to be transmitted in a common time segment are provided in the same time segment in all the output data streams to which the data are to be assigned.
    Type: Grant
    Filed: November 24, 2015
    Date of Patent: March 3, 2020
    Assignee: Carl Zeiss Microscopy GmbH
    Inventors: Andreas Kuehm, Nico Presser, Hardy Thomas Koebe, Joerg Engel
  • Patent number: 10578542
    Abstract: Aspects of the present disclosure include methods and systems for detecting light from a sample in a flow stream by multi-photon counting. Methods according to certain embodiments include irradiating a sample in a flow stream with a light source and detecting light from the sample in the flow stream and counting photons of the detected light by integrating photo-electron charge over a time interval. Methods also include irradiating a sample in a flow stream with a light source, detecting light from the sample in the flow stream and outputting a digital output signal and an analog output signal produced by the detected light. Systems for detecting light from a sample in a flow stream with a detector and counting photons by integrating photo-electron charge over a time interval are also described. Kits having a detector, a photon counter and a flow cell configured to propagate a sample in flow stream are also provided.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: March 3, 2020
    Assignee: BECTON, DICKINSON AND COMPANY
    Inventors: Jianying Cao, Wei Chen
  • Patent number: 10571334
    Abstract: An optical system includes a spectrograph having a concave diffraction grating and a detector. An aperture is selectively positioned by an associated actuator or positioning mechanism either into, or out of, an optical path of the input light beam downstream of a sample and prior to entering the spectrograph. A slit plate having a plurality of different size entrance slits is positioned downstream of the aperture and movable by an associated actuator or positioning mechanism to position one of the plurality of entrance slits in the optical path of the input light beam. A controller coupled to the detector and the actuators is configured to control the actuators to selectively position the aperture and the slit plate to provide a selectable resolution of the spectrograph. The aperture setting and slit plate setting may be determined from a lookup table in response to a request for finer or coarser spectral resolution.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: February 25, 2020
    Assignee: HORIBA INSTRUMENTS INCORPORATED
    Inventors: Harry Jerome Oana, Xiaomei Tong, Ronald Joseph Kovach
  • Patent number: 10561753
    Abstract: A biological indicator analyzer includes a plurality of wells, a plurality of organism detector features, and a user input feature such as a touch screen. Each well is configured to receive a respective biological indicator. Each organism detector feature is configured to detect whether a biological indicator disposed in a corresponding well of the plurality of wells contains a living organism. The touch screen is configured to receive user input and provide information to the user indicating a status of biological indicator analysis. The biological indicator analyzer may be used to analyze a biological indicator that was positioned in a sterilization chamber of a sterilizing cabinet along with at least one medical device that is to be sterilized. The analysis may indicate whether the sterilization cycle in the sterilization chamber as successful.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: February 18, 2020
    Assignee: ASP GLOBAL MANUFACTURING GMBH
    Inventors: Brian J. Thompson, Jacob S. Childs, Chunhui Xie, Marco A. Mangiaterra, Darius D. Eghbal, Margaret D. Shaffer, Jeremy M. Yarwood, Benjamin M. Fryer, Howell B. Schwartz, Philippe Kanh Dang, Yaeer Lev, Venkata Danam
  • Patent number: 10560264
    Abstract: A cryptographic key generator for a first optical transceiver includes a photodetector that receives a continuous wave light beam received via an optical channel from a second optical transceiver. The generator samples and quantizes signals from the photodetector during a plurality of intervals to generate respective samples representing respective numbers of photons incident on the photodetector during each of the plurality of intervals. The generator creates a first cryptographic key from the plurality of digital values. The second optical transceiver receives a continuous wave light beam from the first transceiver and performs the same functions to create a second cryptographic key. Due to the reciprocal nature of the channels, the first and second cryptographic keys match.
    Type: Grant
    Filed: May 29, 2018
    Date of Patent: February 11, 2020
    Assignee: Microsoft Technology Licensing, LLC
    Inventors: Amer A. Hassan, Roy Kuntz
  • Patent number: 10551265
    Abstract: A pressure transducer includes a cavity, a first dipolar molecule disposed within the cavity, and a second dipolar molecule disposed within the cavity. The first dipolar molecule exhibits a quantum rotational state transition at a fixed frequency with respect to cavity pressure. The second dipolar molecule exhibits a quantum rotation state transition at a frequency that varies with cavity pressure.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: February 4, 2020
    Assignee: TEXAS INSTRUMENTS INCORPORATED
    Inventors: Benjamin Stassen Cook, Django Trombley, Adam Joseph Fruehling, Juan Alejandro Herbsommer
  • Patent number: 10545329
    Abstract: The invention relates to a method for observing a fluorescent sample lying in a sample plane, where the sample comprises a fluorescent agent able to emit a fluorescence light wave in a fluorescence spectral band when it is illuminated by an excitation light wave, in an excitation spectral band. The method includes illuminating the sample using a first light source, in a first illumination spectral band in the excitation spectral band, and acquiring a first image of the sample, in the fluorescence spectral band, using an image sensor; and illuminating the sample using a second light source, in a second spectral band, outside of the fluorescence spectral band, and acquiring a second image of the sample, in the second spectral band, using the image sensor.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: January 28, 2020
    Assignee: Commissariat a l'energie atomique et aux energies alternatives
    Inventors: Ondrej Mandula, Cedric Allier
  • Patent number: 10540783
    Abstract: Embodiments for registering features in a repeating pattern are described. These embodiments can include providing an object having a repeating pattern of features and a fiducial. These embodiment can also include obtaining a target image of the object, where the target image includes the repeating pattern of features and the fiducial. These embodiment can also include comparing the fiducial in the target image to reference data, where the reference data includes xy coordinates for a virtual fiducial. These embodiment can also include determining locations for the features in the target image based on the comparison of the virtual fiducial in the reference data to the fiducial in the data from the target image. The fiducial can have at least concentric circles that produce three different signal levels. The locations of the features can be determined at a variance of less than 5 ?m.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: January 21, 2020
    Assignee: ILLUMINA, INC.
    Inventors: John S. Vieceli, Stephen Tanner, John A. Moon, M. Shane Bowen
  • Patent number: 10527729
    Abstract: Laser 3D imaging techniques include splitting a laser temporally-modulated waveform of bandwidth B and duration D from a laser source into a reference beam and a target beam and directing the target beam onto a target. First data is collected, which indicates amplitude and phase of light relative to the reference beam received at each of a plurality of different times during a duration D at each optical detector of an array of one or more optical detectors perpendicular to the target beam. Steps are repeated for multiple sampling conditions, and the first data for the multiple sampling conditions are synthesized to form one or more synthesized sets. A 3D Fourier transform of each synthesized set forms a digital model of the target for each synthesized set with a down-range resolution based on the bandwidth B.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: January 7, 2020
    Assignees: BLACKMORE SENSORS AND ANALYTICS, LLC, MONTANA STATE UNIVERSITY
    Inventors: Stephen C. Crouch, Brant M. Kaylor, Zeb W. Barber, Randy R. Reibel
  • Patent number: 10527556
    Abstract: An optical measuring method includes generating a Bessel beam, filtering the Bessel beam to generate a focused Bessel beam, vertically irradiating the focused Bessel beam onto a substrate in which an opening is formed, and detecting light reflected from the substrate to obtain an image of a bottom surface of the opening.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: January 7, 2020
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Min-Ho Rim, Jung-Soo Kim, Young-Hoon Sohn, Yu-Sin Yang, Chung-Sam Jun, Yun-Jung Jee
  • Patent number: 10520714
    Abstract: Embodiments related to systems and methods for instant structured microscopy where total internal reflection fluorescence techniques are used to improve optical sectioning and signal-to-noise ratio of structured illumination microscopy are disclosed.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: December 31, 2019
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Hari Shroff, Justin Taraska, John Giannini, Yicong Wu, Abhishek Kumar, Min Guo
  • Patent number: 10515273
    Abstract: A method for removing foreign matter from an agricultural product stream of a manufacturing process. The method includes conveying a product stream past an inspection station; scanning a region of the agricultural product stream as it passes the inspection station using at least one light source of a single or different wavelengths; generating hyperspectral images from the scanned region; determining a spectral fingerprint for the agricultural product stream from the hyperspectral images; comparing the spectral fingerprint obtained in step (c) to a spectral fingerprint database containing a plurality of fingerprints using a computer processor to determine whether foreign matter is present and, if present, generating a signal in response thereto; and removing a portion of the conveyed product stream in response to the signal. A system for detecting foreign matter within an agricultural product stream is also provided.
    Type: Grant
    Filed: December 28, 2017
    Date of Patent: December 24, 2019
    Assignee: Altria Client Services LLC
    Inventors: Henry M. Dante, Samuel Timothy Henry, Seetharama C. Deevi
  • Patent number: 10514533
    Abstract: A method for creating a microscope image of an object includes emitting excitation light, illuminating points on the object in a rastering manner, and detecting a raster partial image of a predetermined magnification for each illuminated point. An optical sensor detects emission light from the object excited by the excitation light. Distances between pairs of raster partial images correspond to distances of the illumination points multiplied by a correction factor. A microscopy device includes a light source, a rastering device, an optical sensor, and a deflecting device for deflecting the emission light. The deflecting device feeds excitation light passing through an inlet to the rastering device, light deflected at the rastering device to a first outlet, and emission light passing through the first outlet to the rastering device such that the emission light is deflected from the optical axis in the same direction as the excitation light.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: December 24, 2019
    Assignee: Georg-August-Universitaet Goettingen Stiftung Oeffentlichen Rechts
    Inventors: Joerg Enderlein, Ingo Gregor
  • Patent number: 10506914
    Abstract: Non-white light from an endoscope (201) of a teleoperated surgical system (200) is used to illuminate a surgical site (203). A camera (220L) captures an image of the surgical site, and the image is displayed on a monitor (251). The non-white light illumination minimizes noise in the images of the surgical site presented on the monitor relative to images captured using white light illumination and displayed on the monitor.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: December 17, 2019
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Jeffrey DiCarlo, Tao Zhao, Stephen J. Blumenkranz, Brian D. Hoffman, Geoff Richmond
  • Patent number: 10502949
    Abstract: A LIDAR system comprising a pyramidal timing polygon is having a plurality of flat optically reflective facet surfaces. The pyramidal polygon comprises a plurality of spaced apart apertures disposed about the outer circumference thereof to define the plurality of radially disposed facets. The pyramidal polygon is rigidly attached and aligned with the rotating scanning polygon structures to define a pre-defined angular shift. The rotation of the three polygon assemblies is synchronized with a pulsed laser source whereby, for each laser pulse, the individual pyramid facets are disposed at a predetermined angle, such as a 45 degree angle, with respect to the incoming beam so as to direct it along the beam 1 reflective optical path.
    Type: Grant
    Filed: June 18, 2018
    Date of Patent: December 10, 2019
    Assignee: Irvine Sensors Corp.
    Inventor: Itzhak Sapir
  • Patent number: 10495576
    Abstract: First, an analytical chip having a prism, a metal film that includes a trapping region having immobilized on the surface thereof a trapping element for trapping a substance to be analyzed, and a mark in which the scatter of emitted plasmon scattered light differs from the scatter of plasmon scattered light emitted from the surrounding region, is disposed in a chip holder. Next, the rear surface of the metal film is irradiated with excitation light, plasmon scattered light emitted from the proximity of the mark is detected, and, on the basis of the detected plasmon scattered light, location information for the trap region is obtained. Next, the portion of the rear surface of the metal film that corresponds to the trap region arranged at the detected location is irradiated with excitation light, and fluorescence emitted by a fluorescent substance is detected.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: December 3, 2019
    Assignee: Konica Minolta, Inc.
    Inventors: Masataka Matsuo, Hiroshi Hirayama, Yoshimasa Hamano, Tetsuya Noda, Yoshihiro Okumura
  • Patent number: 10493175
    Abstract: A light-emitting device includes a light-emitting element with a peak emission wavelength in a range of 400 nm to 410 nm and a fluorescent member that contains a first phosphor with a peak emission wavelength in a range of 440 nm to 470 nm containing a Eu-activated alkaline-earth phosphate that contains Cl in a composition, a second phosphor with a peak emission wavelength in a range of 500 nm to 530 nm containing a Eu-activated halogen-containing alkaline-earth silicate, a third phosphor with a peak emission wavelength in a range of 530 nm to 600 nm containing a Ce-activated rare-earth aluminate, and a fourth phosphor with a peak emission wavelength in a range of 600 nm to 660 nm containing a Eu-activated silicon nitride containing Al and at least one of Sr and Ca in a composition.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: December 3, 2019
    Assignee: NICHIA CORPORATION
    Inventors: Hiroaki Ukawa, Ryuichi Nakagami
  • Patent number: 10488639
    Abstract: A detection device for specimens includes an image sensor, a light-guiding structure, and a carrier. The image sensor includes a sensing area and a non-sensing area around the sensing area. The light-guiding structure is disposed on the image sensor. The light-guiding structure includes a central guiding portion, a reflection layer, and first guiding portions. The central guiding portion is located over the sensing area. The reflection layer is disposed on the image sensor and includes channels located over the non-sensing area. The first guiding portions are located in the channels, and connected to the central guiding portion and a side surface of the light-guiding structure. The carrier is disposed on the light-guiding structure, and has wells located over the sensing area. Each of the wells is configured to receive a specimen.
    Type: Grant
    Filed: October 8, 2015
    Date of Patent: November 26, 2019
    Assignee: Visera Technologies Company Limited
    Inventors: Chin-Ching Chang, Han-Lin Wu, Chin-Chuan Hsieh, Wei-Ko Wang, Zong-Ru Tu
  • Patent number: 10481352
    Abstract: An optical amplifier is provided in which radiation levels experienced by an optical fiber are minimized. A sealed enclosure houses an optical fiber. An input optical signal enters on end of the fiber and an amplified output optical signal exits the other end of the optical fiber. Small particles embedded with a gas fill the interior of the enclosure. An optical pump supplies an amplification laser beam coupled to one of the ends of the optical fiber. Due to energy supplied by the amplification laser beam, the input optical signal is amplified upon exiting the optical fiber. At least a portion of the gas embedded in the small particles is released inside the enclosure when the small particles are subjected to heat to provide a gaseous interior in the enclosure that minimizes radiation levels experienced by the optical fiber due to external radiation.
    Type: Grant
    Filed: July 5, 2018
    Date of Patent: November 19, 2019
    Assignee: NORTHROP GRUMMAN SYSTEMS CORPORATION
    Inventor: Ge Wang
  • Patent number: 10473592
    Abstract: Methods of determining and characterizing photosynthesis in plant parts of one or more plants includes capturing a plurality of images of the plant parts of the one or more plants with a sensor are provided. Fluorescence of the plant parts of the one or more plants can be measured by storing a sensor image of observed fluorescence. Light absorbed by the plant parts of the one or more plants can be estimated by observing red and/or infrared reflectance of the plant parts. A characteristic of photosynthesis such as linear electron flow in plant parts of the one or more plants can be derived using the measured fluorescence of the plant parts, the reflectance and the light absorbed by the plant parts, and/or the three-dimensional model comprising the plant parts of the one or more plants. Related apparatus and systems are also provided.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: November 12, 2019
    Assignee: BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY
    Inventors: David Kramer, Jin Chen, Elisabeth Ostendorf, Lei Xu, Jeffrey Cruz, Jeremy J. Brodersen
  • Patent number: 10470664
    Abstract: The present invention provides a mobile-based spectrum imaging device and a method for controlling the same. A mobile-based spectrum imaging device according to an embodiment of the present invention may comprise: an optical fiber for emitting, in a beam form, light which has been collected from a light source; a linear filter which is movably installed, divides the light emitted from the optical fiber into particular wavelength bands, and makes the divided light have a wavelength band changing according to the incidence location of the light; and a control unit for controlling the location of the linear filter such that the location of incident light is changed on the linear filter.
    Type: Grant
    Filed: June 20, 2016
    Date of Patent: November 12, 2019
    Assignee: Daegu Gyeongbuk Institute of Science and Technology
    Inventors: Jae Youn Hwang, Se Hyo Youn
  • Patent number: 10472672
    Abstract: The invention relates to an automatic response/light measurement device and a method therefor, and the purpose is to effectively and quickly perform an optical measurement relating to a reaction with high reliability without increasing a device size. The device is configured to have: a container group in which a plurality of reaction containers are arranged; a measurement mount provided with a plurality of coupling ends that are joinable with apertures of the reaction containers, and have light guide portions that optically connect with the interior of the joined reaction containers; a mount transfer mechanism; a measuring device having a measuring end having at least one light guide portion that is optically connectable to the light guide portions of the coupling ends, that is able to receive light based on an optical state within the reaction containers; an on-mount measuring end transfer mechanism; and a measurement control portion.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: November 12, 2019
    Assignee: UNIVERSAL BIO RESEARCH CO., LTD.
    Inventor: Hideji Tajima
  • Patent number: 10466108
    Abstract: The present invention relates to an electrically thin molybdenum thin film absorber coating for a detector, that is capable of absorbing a fraction of incident electromagnetic radiation over a 1-15 THz spectral range.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: November 5, 2019
    Assignee: United States of America as represented by the Administrator of NASA
    Inventors: Ari D. Brown, Kevin H. Miller, Edward J. Wollack
  • Patent number: 10466892
    Abstract: Provided are an interactive handwriting display device and an interactive handwriting capture device. The interactive handwriting display device has a display panel and a patterned band-pass filter component, and the patterned band-pass filter component has a substrate and multiple band-pass filter units. The interactive handwriting capture device includes an optical signal selector, an image-forming module, a photodetector chip and a microprocessor. By using the interactive handwriting display device with a patterned filtering function and the interactive handwriting capture device with the recognition function, the addressable ITO sensor's need of electrical connection is eliminated, providing interactive operating function and the writing function of high sensitivity and accuracy. Also, the manufacturing complexities are reduced and the integration of components is improved as the touch screens get larger in size.
    Type: Grant
    Filed: October 3, 2017
    Date of Patent: November 5, 2019
    Assignees: CHI HSIANG OPTICS CO., LTD., NEOLAB CONVERGENCE TAIWAN INC.
    Inventors: Po-Hung Yao, Hsien-Ching Chang
  • Patent number: 10469772
    Abstract: A hyperspectral imaging systems includes an imaging sensor, a multispectral filter, and an actuator. The actuator moves the multispectral filter with respect to the imaging sensor to capture a scene with full spectral data. The spectral data of the scene can be stored in a hyperspectral data cube, which can be compressed, processed, stored, and/or sent to a remote location. Each acquired image includes a spatial map of the scene which facilitates pointing, focusing, and data analysis. The spectral measurement parameters can be configured dynamically in order to optimize performance such as spectral resolution, storage capacity, and transmission bandwidth. The system achieves high spectral and spatial resolution, is simple, compact, and lightweight, thereby providing an efficient hyperspectral imaging system.
    Type: Grant
    Filed: December 27, 2017
    Date of Patent: November 5, 2019
    Assignee: Urugus S.A.
    Inventors: Gerardo Gabriel Richarte, Agustina Pose, Juan Manuel Vuletich, Pablo Jais, David Vilaseca, Emiliano Kargieman
  • Patent number: 10458965
    Abstract: A device and system for optically analyzing food products is provided. The device comprises first and second imaging devices respectively sensitive to first and second wavelengths; the imaging devices include a line-scan camera to acquire images of food products at a line in a food-path-facing direction, and a line-scan spectrometer to acquire spectroscopic images at the line. The device includes an optical filter configured to: convey the first wavelengths from the line to the first imaging device; and convey the second wavelengths from the line to the second imaging device. The device includes a frame to align the optical filter and respective optical axes of the first and second imaging devices, relative to each other and the food-path-facing direction, such that the first imaging device and the second imaging device are optically aligned via the optical filter to image the line.
    Type: Grant
    Filed: August 15, 2018
    Date of Patent: October 29, 2019
    Assignee: P & P OPTICA INC.
    Inventors: Krishna Iyer, Olga Ewa Pawluczyk, Bradley Oldenburg, Simon Guthrie, Timothy M. F. Stork, Ewa Osika, David William Lizius, Romuald Pawluczyk, Anthony Robert Shaw, Alexander Baran-Harper
  • Patent number: 10451484
    Abstract: The temperature sensor includes a light pipe and a cap configured to be positioned within a flow path of a fluid. The cap includes a material configured to emit radiation based on a temperature of the material. A light source is configured to emit light through the light pipe toward the cap, and a detector is configured to receive the radiation emitted by the material of the cap and to generate a first signal based on the received radiation emitted by the material. The detector is configured to generate a second signal indicative of a light-induced delta temperature caused by the light emitted toward the inner surface of the cap. The system also includes a controller configured to determine a condition of the temperature sensor based on the first signal and the second signal.
    Type: Grant
    Filed: January 12, 2017
    Date of Patent: October 22, 2019
    Assignee: General Electric Company
    Inventors: Ken Yves Haffner, Guelru Kocer
  • Patent number: 10450603
    Abstract: The fluorescence detection device includes an illumination module and a detection module. The illumination module includes a light source and a first filter. The light source is configured with the first filter to pass a first light beam at a first particular bandwidth along a first optical axis for exciting a targeted fluorescent probe and generating a fluorescent light. The detection module includes a second filter and a photo-detector. The second filter receives the fluorescent light and passes a second light beam at a second particular bandwidth along a second optical axis. The photo-detector receives the second light beam at the second particular bandwidth and converts the second light beam at the second particular bandwidth to an electrical signal. The first optical axis is tilted from the second optical axis at a specific angle ranged from 4.5 degrees to 9.5 degrees.
    Type: Grant
    Filed: June 12, 2017
    Date of Patent: October 22, 2019
    Assignee: DELTA ELECTRONICS INT'L (SINGAPORE) PTE LTD
    Inventors: Bo Ma, Wei-Chen Hsu, Jei-Yin Yiu
  • Patent number: 10451482
    Abstract: A system is configured to determine a color distribution of an object moving along a flow direction relative to a spatial filter. The light emanating from the object is time modulated according to the mask features of the spatial filter. First and second detectors are arranged to sense the modulated light. The first detector senses light having a first wavelength spectrum and generates a first electrical output signal in response to the sensed light. The second detector light senses light having a second wavelength spectrum and generates a second electrical output signal in response to the sensed light. Signals from the first and second detectors include information about color distribution of the object.
    Type: Grant
    Filed: February 14, 2014
    Date of Patent: October 22, 2019
    Assignee: Palo Alto Research Center Incorporated
    Inventors: Joerg Martini, Marshall W. Bern, Noble M. Johnson, Peter Kiesel, Doron Kletter, Bowen Cheng, Michael I. Recht
  • Patent number: 10444102
    Abstract: A pressure transducer includes a cavity, dipolar molecules disposed within the cavity, and pressure measurement circuitry. The pressure measurement circuitry is configured to measure a width of an absorption peak of the dipolar molecules, and to determine a value of pressure in the cavity based on the width of the absorption peak.
    Type: Grant
    Filed: September 7, 2017
    Date of Patent: October 15, 2019
    Assignee: TEXAS INSTRUMENTS INCORPORATED
    Inventors: Juan Alejandro Herbsommer, Adam Joseph Fruehling, Swaminathan Sankaran, Benjamin Stassen Cook
  • Patent number: 10444083
    Abstract: A fiber optic sensing system includes a plurality of optical probes, a light source, and a light splitting unit connecting the light source to the plurality of optical probes. The light splitting unit splits a light emitted from the light source into a plurality of divided lights, the divided lights being transmitted to the plurality of optical probes.
    Type: Grant
    Filed: November 21, 2017
    Date of Patent: October 15, 2019
    Assignee: Watlow Electric Manufacturing Company
    Inventor: Mohammad Nosrati
  • Patent number: 10441174
    Abstract: A method of luminance lifetime imaging includes receiving incident photons at an integrated photodetector from luminescent molecules. The incident photons being received through one or more optical components of a point-of-care device. The method also includes detecting arrival times of the incident photons using the integrated photodetector. A method of analyzing blood glucose includes detecting luminance lifetime characteristics of tissue using, at least in part, an integrated circuit that detects arrival times of incident photons from the tissue. The method also includes analyzing blood glucose based upon the luminance lifetime characteristics.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: October 15, 2019
    Assignee: Tesseract Health, Inc.
    Inventors: Jonathan M. Rothberg, Keith G. Fife, David Boisvert
  • Patent number: 10433921
    Abstract: A method for performing a surgical procedure includes planning a resection of a bone of a patient. A volume of the bone is removed according to the planned resection using a surgical tool. As the bone is removed, data corresponding to a shape and volume of the removed bone is tracked with a computer system operatively coupled to the surgical tool. A prosthesis is implanted onto the bone of the patient based on the tracked data corresponding to the shape of the removed bone.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 8, 2019
    Assignee: Mako Surgical Corp.
    Inventor: Dan Librot
  • Patent number: 10436641
    Abstract: Described are a shutter assembly, a spectrometer, and a method for calibrating a spectrometer. For example, the method may include positioning a shutter including a mirror into a first position in an illumination path of an excitation light beam such that a measurement window is blocked. The mirror may be operable to direct at least one of: (1) the illumination path to a spectral calibration material, (2) a first collection path extending from the spectral calibration material, and (3) a second collection path of a spectral calibration light beam. The method may include directing a returned light from the receiving optics unit to an imaging device; processing the returned light at the imaging device into one or more image signals; analyzing and comparing the image signals with approved image signals; and providing an indication of whether the comparative results of the analysis are within acceptable tolerances.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: October 8, 2019
    Assignee: DIRAMED, LLC
    Inventors: Richard J. Higgins, Brian Lipp, Don Warren Caudy
  • Patent number: 10436655
    Abstract: A photonic displacement sensor comprises a photonic fiber including a) a core section having a first band gap aligned along an extended longitudinal axis, and b) a cladding section surrounding the core section having a second band gap. The first band gap is adapted to block a spectral band of radiation centered on a first wavelength that is directed along the longitudinal axis, and the second band gap is adapted to block a spectral band of radiation centered on a second wavelength that is directed transversely to the longitudinal axis, and wherein displacement is detected based on a shift in at least one of the first and second band gap of the photonic fiber, enabling an intensity of radiation to be detected that is in proportion to the displacement in the photonic fiber.
    Type: Grant
    Filed: July 14, 2017
    Date of Patent: October 8, 2019
    Assignee: Saudi Arabian Oil Company
    Inventors: Enrico Bovero, Gasan Alabedi, Abdullah A. Al-Shahrani