Heterocyclic Compounds Having An Intercyclic Acyclic Methine Linkage Patents (Class 252/301.22)
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Patent number: 10405753Abstract: Sterile and non-toxic pharmaceutical compositions of near IR, closed chain, sulfo-cyanine dyes and methods for visualizing tissue under illumination with near-infrared radiation are provided.Type: GrantFiled: November 10, 2015Date of Patent: September 10, 2019Assignee: Intuitive Surgical Operations, Inc.Inventor: Jonathan Sorger
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Patent number: 9868905Abstract: Compounds containing at least one C—C triple bond of the formula I R1-[A1-Z1]m-A2A3-[Z2-A4]n-[Z3-A5]o-R2??I, which have neutral dielectric anisotropy, to the use thereof for high-frequency components, to liquid-crystalline media comprising the compounds, and to high-frequency components, in particular antennae, especially for the giga- and terahertz region, comprising these media. The liquid-crystalline media serve, for example, for the phase shifting of microwaves for tuneable phased-array antennae.Type: GrantFiled: September 3, 2013Date of Patent: January 16, 2018Assignee: MERCK PATENT GMBHInventors: Constanze Brocke, Christian Jasper, Detlef Pauluth, Atsutaka Manabe
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Patent number: 9850356Abstract: An optical film comprising a cellulose acylate film which comprises a compound denoted by formula 2 below: wherein each of R10 and R11 independently denotes a substituent linked to the triazine ring through —NR12— or —CO—; R12 denotes a hydrogen atom or an optionally substituted alkyl group; n denotes 1; and —X1—R1 is selected from the group consisting of partial structures 11 to 14:Type: GrantFiled: September 2, 2015Date of Patent: December 26, 2017Assignee: FUJIFILM CorporationInventors: Hiroshi Inada, Naozumi Shiraiwa, Yingjie Xu, Yasukazu Kuwayama, Nobutaka Fukagawa, Masaki Noro
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Patent number: 8859679Abstract: The instant invention relates to storage stable aqueous solutions of stilbene optical brighteners with polyvinyl alcohols which can be directly used by the papermaker in that they may be diluted with water and/or be metered directly into a coating composition, to provide coated papers of a particularly high whiteness.Type: GrantFiled: April 5, 2006Date of Patent: October 14, 2014Assignee: Clariant Finance (BVI) LimitedInventors: Andrew Clive Jackson, Alec Stewart Tindal, Mariela Gauto
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Patent number: 8445079Abstract: An object of the present invention is to provide an optical film exhibiting a preferable wavelength dispersion and capable of being formed comparatively thinly. The present invention is an optical film containing the repeating unit represented by the following general formula (II). In the formula (II), A, A?, B, and B? each denote a substituent, a, a?, b, and b? denote the number of substituents of the corresponding A, A?, B, and B?. A, A?, B and B? each independently denote a halogen or an alkyl group having 1 to 4 carbon atoms. R1 and R2 denote a halogen, an alkyl group having 1 to 10 carbon atoms, and the like. X denotes —CO—, —SO2—, and the like.Type: GrantFiled: April 9, 2008Date of Patent: May 21, 2013Assignee: Nitto Denko CorporationInventors: Toshiyuki Iida, Yutaka Ohmori, Miyuki Kurogi
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Patent number: 8309186Abstract: An object of the present invention is to provide an optical film exhibiting a preferable wavelength dispersion and capable of being formed comparatively thinly. The present invention is an optical film containing the repeating unit represented by the following general formula (II). In the formula (II), A, A?, B, and B? each denote a substituent, a, a?, b, and b? denote the number of substituents of the corresponding A, A?, B, and B?. A, A?, B and B? each independently denote a halogen or an alkyl group having 1 to 4 carbon atoms. R1 and R2 denote a halogen, an alkyl group having 1 to 10 carbon atoms, and the like. X denotes —CO—, —SO2—, and the like.Type: GrantFiled: April 9, 2008Date of Patent: November 13, 2012Assignee: Nitto Denko CorporationInventors: Toshiyuki Iida, Yutaka Ohmori, Miyuki Kurogi
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Patent number: 8197722Abstract: Compositions capable of simultaneous two-photon absorption and higher order absorptivities are provided. Compounds having a donor-pi-donor or acceptor-pi-acceptor structure are of particular interest, where the donor is an electron donating group, acceptor is an electron accepting group, and pi is a pi bridge linking the donor and/or acceptor groups. The pi bridge may additionally be substituted with electron donating or withdrawing groups to alter the absorptive wavelength of the structure. Also disclosed are methods of generating an excited state of such compounds through optical stimulation with light using simultaneous absorption of photons of energies individually insufficient to achieve an excited state of the compound, but capable of doing so upon simultaneous absorption of two or more such photons. Applications employing such methods are also provided, including controlled polymerization achieved through focusing of the light source(s) used.Type: GrantFiled: July 30, 2001Date of Patent: June 12, 2012Assignee: The California Institute of TechnologyInventors: Seth Marder, Joseph Perry
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Patent number: 7732215Abstract: The present invention relates to a cyanide detection method using fluorescence and cyanide sensitive boronic acid containing fluorophores, wherein a change in a measured fluorescent property correlates to the concentration of the cyanide compound in a biological or environmental test sample.Type: GrantFiled: September 16, 2004Date of Patent: June 8, 2010Assignee: University of Maryland Biotechnology InstituteInventors: Chris D. Geddes, Ramachandram Badugu, Joseph R. Lakowicz
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Patent number: 7531107Abstract: Compositions comprising (A) a total of from 2 to 30% by weight, based on the total composition (A)+(B), of one or more amino alcohols of formula (1) herein R1, R2, R3 and R4 are each independently of the others hydrogen, 1-C12alkyl,C5-C24aryl or C6-C36aralkyl, and R5 and R6 are each independently of the other hydrogen or C1-C4alkyl; and (B) from 70 to 98% by weight, based on the total composition (A)+(B), of a fluorescent whitening agent of formula (2) herein X is hydrogen, an alkali metal ion, an ammonium ion or a hydroxyalkylammonium radical derived from the amino alcohol of formula (1), and R7, R8, R9 and R10 are each independently of the others —OR11, —NR11R12 or a group of formula (3) wherein R11, and R12 are each independently of the other hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, H2N—CO-alkyl or alkylthio, are distinguished by high solubility in water and by high storage stability of the aqueous solutions.Type: GrantFiled: September 10, 2004Date of Patent: May 12, 2009Assignee: Ciba Specialty Chemicals CorporationInventors: Rainer Hans Traber, Ted Deisenroth, Sandra Galle, Helena Dbaly
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Patent number: 7497971Abstract: The present invention relates to a mixture of fluorescent whitening agents comprising 11 to 20% by weight of a compound of formula (1), and 80 to 89% by weight of a compound of formula (2), wherein R1 denotes hydrogen, C1-C6alkyl, C5-C14aryl or C6-C24aralkyl and X is a bivalent radical of formula (3), (4) or (5) compositions containing the mixture and the use of the compositions for whitening synthetic fibers, in particular, polyester.Type: GrantFiled: December 1, 2003Date of Patent: March 3, 2009Assignee: Ciba Specialty Chemicals CorporationInventors: Jean-Jacques Donzé, Marie Meyberger, Michael Milde, Volker Papendick, Josef Zelger
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Patent number: 7488468Abstract: A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.Type: GrantFiled: September 16, 1999Date of Patent: February 10, 2009Assignees: Schering AG, Fuji Photo Film Co., Ltd.Inventors: Naoto Miwa, Michihito Inagaki, Hiroaki Eguchi, Masafumi Okumura, Yoshio Inagaki, Toru Harada
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Patent number: 7258815Abstract: The use of optical brighteners of the formula (II): in which Y denotes a radical of the formula and the other substituents have the meaning stated in the description, for brightening aqueous coating slips comprising at least one latex binder and at least one synthetic co-binder differing therefrom.Type: GrantFiled: April 16, 2003Date of Patent: August 21, 2007Inventors: Karl-Heinz Drenker, Heinz Giesecke, Bernhard Hunke, Bernd Hauschel, Reiner Gottschalk, Claudia Hundertmark
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Patent number: 7063806Abstract: The present invention relates to fluorescent diketopyrrolopyrroles (“DPPs”) of the formula characterized in that that at least two adjacent substituents R5 to R11 form an aromatic or aliphatic fused ring system, or at least one substituent R5 to R11 is cycloalkyl, aralkyl, alkenyl, cycloalkenyl, alkynyl, a hydroxyl group, a mercapto group, alkylthio, an aryl thioether group, a heterocyclic group, halogen, haloalkyl, haloalkenyl, haloalkynyl, a cyano group, an aldehyde group, a carbonyl group, a carboxyl group, an ester group, a carbamoyl group, a nitro group, a silyl group, a siloxanyl group, a substituted or unsubstituted vinyl, arylamino or diarylamino group; a process for their preparation and their use for the preparation of inks, colorants, pigmented plastics for coatings, non-impact-printing material, color filters, cosmetics, or for the preparation of polymeric ink particles, toners, dye lasers and electroluminescent devices.Type: GrantFiled: June 20, 2002Date of Patent: June 20, 2006Assignee: Ciba Specialty Chemicals CorporationInventors: Hiroshi Yamamoto, Norihisa Dan, Olof Wallquist
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Patent number: 7041235Abstract: The present invention relates to fluorescent diketopyrrolopyrrole analogues of the general formula (I), wherein A1 and A2 are C1–C18alkyl, C2–C18alkenyl, C2–C18alkynyl, C5–C8cycloalkyl, C5–C8cycloalkenyl, aryl or heteroaryl, A3 and A4 are independently of each other C1–C18alkyl, Ar3, —CR30R31—(CH2)m—Ar3, or Y—R32, wherein R30 and R31 independently of each other stand for hydrogen or C1–C4alkyl, or phenyl which can be substituted up to three times with C1–C3alkyl, Ar3 stands for aryl, in particular phenyl or 1- or 2-naphthyl, C5–C8cycloalkyl, in particular cyclohexyl, or heteroaryl, which can be substituted one to three times with C1–C8alkyl, C1–C8alkoxy, halogen or phenyl, which can be substituted with C1–C8alkyl or C1–C8alkoxy one to three times, and m stands for 0, 1, 2, 3 or 4, Y is C(O)— or SO2— and R32 is C1–C18alkyl, Ar3, or aralkyl and A3 can additionally be hydrogen, C1–C8alkyloxycarbonyl, such as tertbutoxycarbonyl, or aralkyloxycarbonyl, such as benzyloxycarbonyl, a process for their preparation andType: GrantFiled: August 1, 2002Date of Patent: May 9, 2006Assignee: Ciba Specialty Chemicals CorporationInventors: Colin Morton, David Macdonald Smith, Abul Iqbal
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Patent number: 6890454Abstract: The invention relates to an optical brightener mixture (W) comprising optical brighteners (A) of formula (Ia), and (B) of formula (Ib) and optionally (C) of formula (Ic) as defined herein, their concentrated aqueous solutions (S), their production and their use.Type: GrantFiled: January 8, 2002Date of Patent: May 10, 2005Assignee: Clariant Finance (BVI) LimitedInventors: John Martin Farrar, Andrew Clive Jackson, Alec Stewart Tindal
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Patent number: 6740257Abstract: Disclosed is a modular fluorescence sensor having the following general formula: Where Fl is a fluorophore, N is a nitrogen atom, Bd1 and Bd2 are independently selected binding groups, Sp is an aliphatic spacer, and An is an anchor group for attaching the sensor to solid substrates. n=1 or 2, m=1 or 2, x is an integer, and y=1 or 2. The binding groups are capable of binding an analyte molecule to form a stable 1:1 complex. In a preferred embodiment, the Bd1 is R1—B(OH)2 and Bd2 is R2—B(OH)2. R1 and R2 are aliphatic or aromatic functional groups selected independently from each other and B is a boron atom. The present invention also provides methods of synthesizing a modular fluorescence sensor and its use in labeling solid substrates.Type: GrantFiled: January 17, 2002Date of Patent: May 25, 2004Assignee: Beckman Coulter, Inc.Inventors: Susumu Arimori, Tony D. James
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Patent number: 6737393Abstract: A liquid bubble solution comprising by volume: 45%˜70% water, 8%˜25% surface active agent, 2% glycerin, 1%˜2% fluorescent brightening agent, 4%˜6% luminous powder and 15%˜20% polyvinyl alcohol, and adapted to produce bubbles that provide illumination when viewed in the dark and under an external source of invisible ultraviolet or infrared radiation; the adoption of the luminous powder provides the function of illuminating in the dark while the polyvinyl alcohol forms a polyvinyl alcohol film on the surface of the bubble, making the bubble touchable and unbreakable.Type: GrantFiled: August 7, 2003Date of Patent: May 18, 2004Inventor: Mon-Sheng Lin
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Publication number: 20040074021Abstract: The invention relates to an optical brightener mixture (W) comprising optical brighteners (A) of formula (Ia), and (B) of formula (Ib) and optionally (C) of formula (Ic) as defined herein, their concentrated aqueous solutions (S), their production and their use.Type: ApplicationFiled: June 25, 2003Publication date: April 22, 2004Inventors: John Martin Farrar, Andrew Clive Jackson, Alec Stewart Tindal
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Patent number: 6656612Abstract: Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I): L&Parenopenst;A)m (I) wherein A represents a heterocyclic group in which two or more aromatic heterocycles are condensed; m represents an integer of 2 or more, and the heterocyclic groups represented by A may be the same or different; and L represents a connecting group.Type: GrantFiled: August 21, 2002Date of Patent: December 2, 2003Assignee: Fuji Photo Film Co., Ltd.Inventors: Hisashi Okada, Toshihiro Ise
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Patent number: 6649089Abstract: A red fluorescent material comprising a compound of Formula I: wherein R1, R2, R3, R4, R5, and R6 each independently represents a linear or branched aliphatic group having from 1 to 10 carbon atoms or an aromatic group having from 5 to 20 carbon atoms.Type: GrantFiled: January 20, 2003Date of Patent: November 18, 2003Assignee: E-Ray Optoelectronics Technology Co., Ltd.Inventors: Min-Jong Chang, Wen-Yao Huang, Wen-Chin Huang
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Publication number: 20030164475Abstract: Described is a process for preparing concentrated solutions or suspensions of anionic organic compounds which comprises a) acidifying an aqueous solution or suspension of an anionic organic compound containing salts and/or impurities to a pH of 4.5 or less, if the pH is above this value, so that b) the anionic organic compound is water-insoluble and precipitates in the form of the free acid, c) bringing the suspension to a salt content below 2% by weight, based on the total weight of the retentate, by means of ultrafiltration with a membrane having pore diameters of from 0.001 to 0.02 &mgr;m, and d) optionally washing out the salts with water having a pH below 4,5, e) optionally carrying out acid-free washing with water thereafter, and then f) concentrating, so that the amount of anionic organic compound is 5-50% by weight, and g) if desired, bringing the anionic organic compound into solution by adding an appropriate base.Type: ApplicationFiled: November 22, 2002Publication date: September 4, 2003Inventors: Jacek Malisz, Adolf Kaser, Rainer Kaufel, Holger Lautenbach, Elke Polley, Martina Hoffmann
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Patent number: 6608228Abstract: Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or electron accepting groups. The bridge may be substituted with a variety of substituents as well. Solubility, lipophilicity, absorption maxima and other characteristics of the compounds may be tailored by changing the electron donating groups or electron accepting groups, the substituents attached to or the length of the pi-conjugated bridge. Numerous photophysical and photochemical methods are enabled by converting these compounds to electronically excited states upon simultaneous absorption of at least two photons of radiation. The compounds have large two-photon or higher-order absorptivities such that upon absorption, one or more Lewis acidic species, Lewis basic species, radical species or ionic species are formed.Type: GrantFiled: April 15, 1999Date of Patent: August 19, 2003Assignee: California Institute of TechnologyInventors: Brian Cumpston, Matthew Lipson, Seth R. Marder, Joseph W. Perry
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Publication number: 20030134148Abstract: Disclosed is a novel methine compound, for examples, which is represented by the following formula (I): 1Type: ApplicationFiled: November 8, 2002Publication date: July 17, 2003Applicant: FUJI PHOTO FILM CO., LTD.Inventors: Hisashi Okada, Terukazu Yanagi
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Patent number: 6533961Abstract: Daylight fluorescent articles are disclosed that utilize durable fluorescent pigment particles resulting from a fluorescent dye incorporated within a matrix polymer selected from polycarbonate, polyester and mixtures thereof and where the particles are of various desired shapes and sizes. Embodiments of such fluorescent pigment particles may also be retroreflective and are especially useful for pavement marking surfaces and retroreflective products for highway transportation safety.Type: GrantFiled: February 12, 2001Date of Patent: March 18, 2003Assignee: 3M Innovative Properties CompanyInventors: R. Ellen Harelstad, David M. Burns, Lee A. Pavelka
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Publication number: 20020127428Abstract: An organic light emitting display is provided which comprises as an emitting layer a fluorescent dye having at least one amine moiety substituted with two aryl groups. Also provided are new fluorescent compounds having N-aryl substituents which exhibit reduced pH sensitivity and enhanced stability to protonation.Type: ApplicationFiled: March 6, 2001Publication date: September 12, 2002Applicant: International Business Machines CorporationInventors: Sally Ann Swanson, Gregory Michael Wallraff
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Patent number: 6387672Abstract: Disclosed is a modular fluorescence sensor having the following general formula: where Fl is a fluorophore, N is a nitrogen atom, Bd1 and Bd2 are independently selected binding groups, Sp is an aliphatic spacer, and An is an anchor group for attaching the sensor to solid substrates. n=1 or 2, m=1 or 2, x is an integer, and y=1 or 2. The binding groups are capable of binding an analyte molecule to form a stable 1:1 complex. In a preferred embodiment, the Bd1 is R1—B(OH)2 and Bd2 is R2—B(OH)2. R1 and R2 are aliphatic or aromatic functional groups selected independently from each other and B is a boron atom. The present invention also provides methods of synthesizing a modular fluorescence sensor and its use in labeling solid substrates.Type: GrantFiled: December 4, 2000Date of Patent: May 14, 2002Assignee: Beckman Coulter, Inc.Inventors: Susumu Arimori, Tony D. James
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Patent number: 6274065Abstract: Preparation of a solid fluorescent composition comprising (1) mixing a host chromophore and an effective amount of a pigment precursor in a solvent, then generating a pigment as guest chromophore in-situ from the pigment precursor, and, subsequently, isolating the mixture of the host and guest chromophores, thereby forming a solid solution, or (2) mixing a polymer as a matrix or a polymer precursor and a pigment precursor in a solvent, if desired in the presence of a chromophore being a host component, then generating a pigment in-situ from the pigment precursor (being the guest component if a host component is present), and, subsequently, isolating the mixture of polymer and pigment, and—if present—the host component, thereby forming a solid solution, wherein in all cases where there is a host component, the absorption spectrum of the pigment (guest chromophore) overlaps with the fluorescence emission spectrum of the host chromophore.Type: GrantFiled: February 3, 1998Date of Patent: August 14, 2001Assignee: Ciba Specialty Chemicals CorporationInventors: Takashi Deno, Kunihiko Kodama, Abul Iqbal, Brian Gerrard Devlin
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Patent number: 6218137Abstract: Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or sulfur-containing heterocyclic ring system bearing an exocyclic carbon-carbon double bond. The double bond is further substituted at the distal carbon with a phosphate group and an oxygen or sulfur atom-containing group. Novel compositions further comprising a cationic aromatic compound (CAC) in addition to the heterocyclic phosphate compound are provided. The addition of the CAC in the composition greatly increases the production of chemiluminescence and provides improved detection sensitivity. Compositions further comprising an anionic surfactant and a non-ionic surfactant provide additional improvements in detection sensitivity.Type: GrantFiled: March 31, 2000Date of Patent: April 17, 2001Assignee: Lumigen, Inc.Inventors: Hashem Akhavan-Tafti, Zahra Arghavani, Renuka DeSilva