Heterocyclic Compounds Having An Intercyclic Acyclic Methine Linkage Patents (Class 252/301.22)
  • Patent number: 10405753
    Abstract: Sterile and non-toxic pharmaceutical compositions of near IR, closed chain, sulfo-cyanine dyes and methods for visualizing tissue under illumination with near-infrared radiation are provided.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: September 10, 2019
    Assignee: Intuitive Surgical Operations, Inc.
    Inventor: Jonathan Sorger
  • Patent number: 9868905
    Abstract: Compounds containing at least one C—C triple bond of the formula I R1-[A1-Z1]m-A2A3-[Z2-A4]n-[Z3-A5]o-R2??I, which have neutral dielectric anisotropy, to the use thereof for high-frequency components, to liquid-crystalline media comprising the compounds, and to high-frequency components, in particular antennae, especially for the giga- and terahertz region, comprising these media. The liquid-crystalline media serve, for example, for the phase shifting of microwaves for tuneable phased-array antennae.
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: January 16, 2018
    Assignee: MERCK PATENT GMBH
    Inventors: Constanze Brocke, Christian Jasper, Detlef Pauluth, Atsutaka Manabe
  • Patent number: 9850356
    Abstract: An optical film comprising a cellulose acylate film which comprises a compound denoted by formula 2 below: wherein each of R10 and R11 independently denotes a substituent linked to the triazine ring through —NR12— or —CO—; R12 denotes a hydrogen atom or an optionally substituted alkyl group; n denotes 1; and —X1—R1 is selected from the group consisting of partial structures 11 to 14:
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: December 26, 2017
    Assignee: FUJIFILM Corporation
    Inventors: Hiroshi Inada, Naozumi Shiraiwa, Yingjie Xu, Yasukazu Kuwayama, Nobutaka Fukagawa, Masaki Noro
  • Patent number: 8859679
    Abstract: The instant invention relates to storage stable aqueous solutions of stilbene optical brighteners with polyvinyl alcohols which can be directly used by the papermaker in that they may be diluted with water and/or be metered directly into a coating composition, to provide coated papers of a particularly high whiteness.
    Type: Grant
    Filed: April 5, 2006
    Date of Patent: October 14, 2014
    Assignee: Clariant Finance (BVI) Limited
    Inventors: Andrew Clive Jackson, Alec Stewart Tindal, Mariela Gauto
  • Patent number: 8445079
    Abstract: An object of the present invention is to provide an optical film exhibiting a preferable wavelength dispersion and capable of being formed comparatively thinly. The present invention is an optical film containing the repeating unit represented by the following general formula (II). In the formula (II), A, A?, B, and B? each denote a substituent, a, a?, b, and b? denote the number of substituents of the corresponding A, A?, B, and B?. A, A?, B and B? each independently denote a halogen or an alkyl group having 1 to 4 carbon atoms. R1 and R2 denote a halogen, an alkyl group having 1 to 10 carbon atoms, and the like. X denotes —CO—, —SO2—, and the like.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: May 21, 2013
    Assignee: Nitto Denko Corporation
    Inventors: Toshiyuki Iida, Yutaka Ohmori, Miyuki Kurogi
  • Patent number: 8309186
    Abstract: An object of the present invention is to provide an optical film exhibiting a preferable wavelength dispersion and capable of being formed comparatively thinly. The present invention is an optical film containing the repeating unit represented by the following general formula (II). In the formula (II), A, A?, B, and B? each denote a substituent, a, a?, b, and b? denote the number of substituents of the corresponding A, A?, B, and B?. A, A?, B and B? each independently denote a halogen or an alkyl group having 1 to 4 carbon atoms. R1 and R2 denote a halogen, an alkyl group having 1 to 10 carbon atoms, and the like. X denotes —CO—, —SO2—, and the like.
    Type: Grant
    Filed: April 9, 2008
    Date of Patent: November 13, 2012
    Assignee: Nitto Denko Corporation
    Inventors: Toshiyuki Iida, Yutaka Ohmori, Miyuki Kurogi
  • Patent number: 8197722
    Abstract: Compositions capable of simultaneous two-photon absorption and higher order absorptivities are provided. Compounds having a donor-pi-donor or acceptor-pi-acceptor structure are of particular interest, where the donor is an electron donating group, acceptor is an electron accepting group, and pi is a pi bridge linking the donor and/or acceptor groups. The pi bridge may additionally be substituted with electron donating or withdrawing groups to alter the absorptive wavelength of the structure. Also disclosed are methods of generating an excited state of such compounds through optical stimulation with light using simultaneous absorption of photons of energies individually insufficient to achieve an excited state of the compound, but capable of doing so upon simultaneous absorption of two or more such photons. Applications employing such methods are also provided, including controlled polymerization achieved through focusing of the light source(s) used.
    Type: Grant
    Filed: July 30, 2001
    Date of Patent: June 12, 2012
    Assignee: The California Institute of Technology
    Inventors: Seth Marder, Joseph Perry
  • Patent number: 7732215
    Abstract: The present invention relates to a cyanide detection method using fluorescence and cyanide sensitive boronic acid containing fluorophores, wherein a change in a measured fluorescent property correlates to the concentration of the cyanide compound in a biological or environmental test sample.
    Type: Grant
    Filed: September 16, 2004
    Date of Patent: June 8, 2010
    Assignee: University of Maryland Biotechnology Institute
    Inventors: Chris D. Geddes, Ramachandram Badugu, Joseph R. Lakowicz
  • Patent number: 7531107
    Abstract: Compositions comprising (A) a total of from 2 to 30% by weight, based on the total composition (A)+(B), of one or more amino alcohols of formula (1) herein R1, R2, R3 and R4 are each independently of the others hydrogen, 1-C12alkyl,C5-C24aryl or C6-C36aralkyl, and R5 and R6 are each independently of the other hydrogen or C1-C4alkyl; and (B) from 70 to 98% by weight, based on the total composition (A)+(B), of a fluorescent whitening agent of formula (2) herein X is hydrogen, an alkali metal ion, an ammonium ion or a hydroxyalkylammonium radical derived from the amino alcohol of formula (1), and R7, R8, R9 and R10 are each independently of the others —OR11, —NR11R12 or a group of formula (3) wherein R11, and R12 are each independently of the other hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, carboxyalkyl, H2N—CO-alkyl or alkylthio, are distinguished by high solubility in water and by high storage stability of the aqueous solutions.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: May 12, 2009
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Rainer Hans Traber, Ted Deisenroth, Sandra Galle, Helena Dbaly
  • Patent number: 7497971
    Abstract: The present invention relates to a mixture of fluorescent whitening agents comprising 11 to 20% by weight of a compound of formula (1), and 80 to 89% by weight of a compound of formula (2), wherein R1 denotes hydrogen, C1-C6alkyl, C5-C14aryl or C6-C24aralkyl and X is a bivalent radical of formula (3), (4) or (5) compositions containing the mixture and the use of the compositions for whitening synthetic fibers, in particular, polyester.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: March 3, 2009
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Jean-Jacques Donzé, Marie Meyberger, Michael Milde, Volker Papendick, Josef Zelger
  • Patent number: 7488468
    Abstract: A near infrared fluorescent contrast agent comprising a compound having three or more sulfonic acid groups in a molecule, and a method of fluorescence imaging comprising introducing the near infrared fluorescent contrast agent of the present invention into a living body, exposing the body to an excitation light, and detecting near infrared fluorescence from the contrast agent. The near infrared fluorescent contrast agent of the present invention is excited by an excitation light and emits near infrared fluorescence. This infrared fluorescence is superior in transmission through biological tissues. Thus, detection of lesions in the deep part of a living body has been made possible. In addition, the inventive contrast agent is superior in water solubility and low toxic, and therefore, it can be used safely.
    Type: Grant
    Filed: September 16, 1999
    Date of Patent: February 10, 2009
    Assignees: Schering AG, Fuji Photo Film Co., Ltd.
    Inventors: Naoto Miwa, Michihito Inagaki, Hiroaki Eguchi, Masafumi Okumura, Yoshio Inagaki, Toru Harada
  • Patent number: 7258815
    Abstract: The use of optical brighteners of the formula (II): in which Y denotes a radical of the formula and the other substituents have the meaning stated in the description, for brightening aqueous coating slips comprising at least one latex binder and at least one synthetic co-binder differing therefrom.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: August 21, 2007
    Inventors: Karl-Heinz Drenker, Heinz Giesecke, Bernhard Hunke, Bernd Hauschel, Reiner Gottschalk, Claudia Hundertmark
  • Patent number: 7063806
    Abstract: The present invention relates to fluorescent diketopyrrolopyrroles (“DPPs”) of the formula characterized in that that at least two adjacent substituents R5 to R11 form an aromatic or aliphatic fused ring system, or at least one substituent R5 to R11 is cycloalkyl, aralkyl, alkenyl, cycloalkenyl, alkynyl, a hydroxyl group, a mercapto group, alkylthio, an aryl thioether group, a heterocyclic group, halogen, haloalkyl, haloalkenyl, haloalkynyl, a cyano group, an aldehyde group, a carbonyl group, a carboxyl group, an ester group, a carbamoyl group, a nitro group, a silyl group, a siloxanyl group, a substituted or unsubstituted vinyl, arylamino or diarylamino group; a process for their preparation and their use for the preparation of inks, colorants, pigmented plastics for coatings, non-impact-printing material, color filters, cosmetics, or for the preparation of polymeric ink particles, toners, dye lasers and electroluminescent devices.
    Type: Grant
    Filed: June 20, 2002
    Date of Patent: June 20, 2006
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Hiroshi Yamamoto, Norihisa Dan, Olof Wallquist
  • Patent number: 7041235
    Abstract: The present invention relates to fluorescent diketopyrrolopyrrole analogues of the general formula (I), wherein A1 and A2 are C1–C18alkyl, C2–C18alkenyl, C2–C18alkynyl, C5–C8cycloalkyl, C5–C8cycloalkenyl, aryl or heteroaryl, A3 and A4 are independently of each other C1–C18alkyl, Ar3, —CR30R31—(CH2)m—Ar3, or Y—R32, wherein R30 and R31 independently of each other stand for hydrogen or C1–C4alkyl, or phenyl which can be substituted up to three times with C1–C3alkyl, Ar3 stands for aryl, in particular phenyl or 1- or 2-naphthyl, C5–C8cycloalkyl, in particular cyclohexyl, or heteroaryl, which can be substituted one to three times with C1–C8alkyl, C1–C8alkoxy, halogen or phenyl, which can be substituted with C1–C8alkyl or C1–C8alkoxy one to three times, and m stands for 0, 1, 2, 3 or 4, Y is C(O)— or SO2— and R32 is C1–C18alkyl, Ar3, or aralkyl and A3 can additionally be hydrogen, C1–C8alkyloxycarbonyl, such as tertbutoxycarbonyl, or aralkyloxycarbonyl, such as benzyloxycarbonyl, a process for their preparation and
    Type: Grant
    Filed: August 1, 2002
    Date of Patent: May 9, 2006
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Colin Morton, David Macdonald Smith, Abul Iqbal
  • Patent number: 6890454
    Abstract: The invention relates to an optical brightener mixture (W) comprising optical brighteners (A) of formula (Ia), and (B) of formula (Ib) and optionally (C) of formula (Ic) as defined herein, their concentrated aqueous solutions (S), their production and their use.
    Type: Grant
    Filed: January 8, 2002
    Date of Patent: May 10, 2005
    Assignee: Clariant Finance (BVI) Limited
    Inventors: John Martin Farrar, Andrew Clive Jackson, Alec Stewart Tindal
  • Patent number: 6740257
    Abstract: Disclosed is a modular fluorescence sensor having the following general formula: Where Fl is a fluorophore, N is a nitrogen atom, Bd1 and Bd2 are independently selected binding groups, Sp is an aliphatic spacer, and An is an anchor group for attaching the sensor to solid substrates. n=1 or 2, m=1 or 2, x is an integer, and y=1 or 2. The binding groups are capable of binding an analyte molecule to form a stable 1:1 complex. In a preferred embodiment, the Bd1 is R1—B(OH)2 and Bd2 is R2—B(OH)2. R1 and R2 are aliphatic or aromatic functional groups selected independently from each other and B is a boron atom. The present invention also provides methods of synthesizing a modular fluorescence sensor and its use in labeling solid substrates.
    Type: Grant
    Filed: January 17, 2002
    Date of Patent: May 25, 2004
    Assignee: Beckman Coulter, Inc.
    Inventors: Susumu Arimori, Tony D. James
  • Patent number: 6737393
    Abstract: A liquid bubble solution comprising by volume: 45%˜70% water, 8%˜25% surface active agent, 2% glycerin, 1%˜2% fluorescent brightening agent, 4%˜6% luminous powder and 15%˜20% polyvinyl alcohol, and adapted to produce bubbles that provide illumination when viewed in the dark and under an external source of invisible ultraviolet or infrared radiation; the adoption of the luminous powder provides the function of illuminating in the dark while the polyvinyl alcohol forms a polyvinyl alcohol film on the surface of the bubble, making the bubble touchable and unbreakable.
    Type: Grant
    Filed: August 7, 2003
    Date of Patent: May 18, 2004
    Inventor: Mon-Sheng Lin
  • Publication number: 20040074021
    Abstract: The invention relates to an optical brightener mixture (W) comprising optical brighteners (A) of formula (Ia), and (B) of formula (Ib) and optionally (C) of formula (Ic) as defined herein, their concentrated aqueous solutions (S), their production and their use.
    Type: Application
    Filed: June 25, 2003
    Publication date: April 22, 2004
    Inventors: John Martin Farrar, Andrew Clive Jackson, Alec Stewart Tindal
  • Patent number: 6656612
    Abstract: Disclosed is a material for a light emitting device excellent in color purity, good in light emitting characteristics and excellent in stability, which consists of a compound represented by the following general formula (I): L&Parenopenst;A)m  (I) wherein A represents a heterocyclic group in which two or more aromatic heterocycles are condensed; m represents an integer of 2 or more, and the heterocyclic groups represented by A may be the same or different; and L represents a connecting group.
    Type: Grant
    Filed: August 21, 2002
    Date of Patent: December 2, 2003
    Assignee: Fuji Photo Film Co., Ltd.
    Inventors: Hisashi Okada, Toshihiro Ise
  • Patent number: 6649089
    Abstract: A red fluorescent material comprising a compound of Formula I: wherein R1, R2, R3, R4, R5, and R6 each independently represents a linear or branched aliphatic group having from 1 to 10 carbon atoms or an aromatic group having from 5 to 20 carbon atoms.
    Type: Grant
    Filed: January 20, 2003
    Date of Patent: November 18, 2003
    Assignee: E-Ray Optoelectronics Technology Co., Ltd.
    Inventors: Min-Jong Chang, Wen-Yao Huang, Wen-Chin Huang
  • Publication number: 20030164475
    Abstract: Described is a process for preparing concentrated solutions or suspensions of anionic organic compounds which comprises a) acidifying an aqueous solution or suspension of an anionic organic compound containing salts and/or impurities to a pH of 4.5 or less, if the pH is above this value, so that b) the anionic organic compound is water-insoluble and precipitates in the form of the free acid, c) bringing the suspension to a salt content below 2% by weight, based on the total weight of the retentate, by means of ultrafiltration with a membrane having pore diameters of from 0.001 to 0.02 &mgr;m, and d) optionally washing out the salts with water having a pH below 4,5, e) optionally carrying out acid-free washing with water thereafter, and then f) concentrating, so that the amount of anionic organic compound is 5-50% by weight, and g) if desired, bringing the anionic organic compound into solution by adding an appropriate base.
    Type: Application
    Filed: November 22, 2002
    Publication date: September 4, 2003
    Inventors: Jacek Malisz, Adolf Kaser, Rainer Kaufel, Holger Lautenbach, Elke Polley, Martina Hoffmann
  • Patent number: 6608228
    Abstract: Disclosed are highly efficient multiphoton absorbing compounds and methods of their use. The compounds generally include a bridge of pi-conjugated bonds connecting electron donating groups or electron accepting groups. The bridge may be substituted with a variety of substituents as well. Solubility, lipophilicity, absorption maxima and other characteristics of the compounds may be tailored by changing the electron donating groups or electron accepting groups, the substituents attached to or the length of the pi-conjugated bridge. Numerous photophysical and photochemical methods are enabled by converting these compounds to electronically excited states upon simultaneous absorption of at least two photons of radiation. The compounds have large two-photon or higher-order absorptivities such that upon absorption, one or more Lewis acidic species, Lewis basic species, radical species or ionic species are formed.
    Type: Grant
    Filed: April 15, 1999
    Date of Patent: August 19, 2003
    Assignee: California Institute of Technology
    Inventors: Brian Cumpston, Matthew Lipson, Seth R. Marder, Joseph W. Perry
  • Publication number: 20030134148
    Abstract: Disclosed is a novel methine compound, for examples, which is represented by the following formula (I): 1
    Type: Application
    Filed: November 8, 2002
    Publication date: July 17, 2003
    Applicant: FUJI PHOTO FILM CO., LTD.
    Inventors: Hisashi Okada, Terukazu Yanagi
  • Patent number: 6533961
    Abstract: Daylight fluorescent articles are disclosed that utilize durable fluorescent pigment particles resulting from a fluorescent dye incorporated within a matrix polymer selected from polycarbonate, polyester and mixtures thereof and where the particles are of various desired shapes and sizes. Embodiments of such fluorescent pigment particles may also be retroreflective and are especially useful for pavement marking surfaces and retroreflective products for highway transportation safety.
    Type: Grant
    Filed: February 12, 2001
    Date of Patent: March 18, 2003
    Assignee: 3M Innovative Properties Company
    Inventors: R. Ellen Harelstad, David M. Burns, Lee A. Pavelka
  • Publication number: 20020127428
    Abstract: An organic light emitting display is provided which comprises as an emitting layer a fluorescent dye having at least one amine moiety substituted with two aryl groups. Also provided are new fluorescent compounds having N-aryl substituents which exhibit reduced pH sensitivity and enhanced stability to protonation.
    Type: Application
    Filed: March 6, 2001
    Publication date: September 12, 2002
    Applicant: International Business Machines Corporation
    Inventors: Sally Ann Swanson, Gregory Michael Wallraff
  • Patent number: 6387672
    Abstract: Disclosed is a modular fluorescence sensor having the following general formula: where Fl is a fluorophore, N is a nitrogen atom, Bd1 and Bd2 are independently selected binding groups, Sp is an aliphatic spacer, and An is an anchor group for attaching the sensor to solid substrates. n=1 or 2, m=1 or 2, x is an integer, and y=1 or 2. The binding groups are capable of binding an analyte molecule to form a stable 1:1 complex. In a preferred embodiment, the Bd1 is R1—B(OH)2 and Bd2 is R2—B(OH)2. R1 and R2 are aliphatic or aromatic functional groups selected independently from each other and B is a boron atom. The present invention also provides methods of synthesizing a modular fluorescence sensor and its use in labeling solid substrates.
    Type: Grant
    Filed: December 4, 2000
    Date of Patent: May 14, 2002
    Assignee: Beckman Coulter, Inc.
    Inventors: Susumu Arimori, Tony D. James
  • Patent number: 6274065
    Abstract: Preparation of a solid fluorescent composition comprising (1) mixing a host chromophore and an effective amount of a pigment precursor in a solvent, then generating a pigment as guest chromophore in-situ from the pigment precursor, and, subsequently, isolating the mixture of the host and guest chromophores, thereby forming a solid solution, or (2) mixing a polymer as a matrix or a polymer precursor and a pigment precursor in a solvent, if desired in the presence of a chromophore being a host component, then generating a pigment in-situ from the pigment precursor (being the guest component if a host component is present), and, subsequently, isolating the mixture of polymer and pigment, and—if present—the host component, thereby forming a solid solution, wherein in all cases where there is a host component, the absorption spectrum of the pigment (guest chromophore) overlaps with the fluorescence emission spectrum of the host chromophore.
    Type: Grant
    Filed: February 3, 1998
    Date of Patent: August 14, 2001
    Assignee: Ciba Specialty Chemicals Corporation
    Inventors: Takashi Deno, Kunihiko Kodama, Abul Iqbal, Brian Gerrard Devlin
  • Patent number: 6218137
    Abstract: Novel heterocyclic compounds which generate chemiluminescence on reaction with a phosphatase enzyme are provided as well as a process for their preparation and intermediates useful therein. The compounds comprise a nitrogen, oxygen or sulfur-containing heterocyclic ring system bearing an exocyclic carbon-carbon double bond. The double bond is further substituted at the distal carbon with a phosphate group and an oxygen or sulfur atom-containing group. Novel compositions further comprising a cationic aromatic compound (CAC) in addition to the heterocyclic phosphate compound are provided. The addition of the CAC in the composition greatly increases the production of chemiluminescence and provides improved detection sensitivity. Compositions further comprising an anionic surfactant and a non-ionic surfactant provide additional improvements in detection sensitivity.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: April 17, 2001
    Assignee: Lumigen, Inc.
    Inventors: Hashem Akhavan-Tafti, Zahra Arghavani, Renuka DeSilva