Nonreactive Analytical, Testing, Or Indicating Compositions Patents (Class 252/408.1)
  • Patent number: 6444471
    Abstract: A control composition, and method of preparing a control composition, that includes stabilized, maturation-arrested reticulocytes, and a complete blood count base including mature erythrocytes, stabilized white cells and stabilized platelets, or analogs thereof.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: September 3, 2002
    Assignee: Research & Diagnostic Systems, Inc.
    Inventor: Alan M. Johnson
  • Publication number: 20020110180
    Abstract: Temperature-sensing compositions can include an inorganic material, such as a semiconductor nanocrystal. The nanocrystal can be a dependable and accurate indicator of temperature. The intensity of emission of the nanocrystal varies with temperature and can be highly sensitive to surface temperature. The nanocrystals can be processed with a binder to form a matrix, which can be varied by altering the chemical nature of the surface of the nanocrystal. A nanocrystal with a compatibilizing outer layer can be incorporated into a coating formulation and retain its temperature sensitive emissive properties.
    Type: Application
    Filed: February 9, 2001
    Publication date: August 15, 2002
    Inventors: Alfred A. Barney, Moungi G. Bawendi, Daniel G. Nocera, Christina M. Rudzinski, Vikram C. Sundar, Glen W. Walker
  • Patent number: 6420184
    Abstract: A composition of matter suitable for use in a reversible thermometer is disclosed which comprises a thermally responsive material capable of being supercooled at least for several minutes, and subject to a change in state from a solid to a liquid substantially at a predetermined temperature; means for visually observing the change in state; and a matrix forming material comprising an amorphous organic compound, the matrix forming material being insoluble in the thermally responsive material; whereby the thermally responsive material is dispersed within the matrix forcing material, the composition of matter being reversibly responsive to changes in temperature, and remaining in the liquid state for a time sufficient to permit a user of the composition to observe the change in state. The preferred matrix forming material is polyisobutylene, and the preferred thermally responsive material is a solid solution of ortho-chloronitrobenzene and ortho-bromonitrobenzene.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: July 16, 2002
    Assignee: 3M Innovative Properties Company
    Inventor: Craig R. Hof
  • Patent number: 6406915
    Abstract: Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems. The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, a nucleated red blood cell component, a platelet component and a reticulated platelet component. Methods of making and using the control compositions are also provided.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: June 18, 2002
    Assignee: Streck Laboratoreis, Inc.
    Inventors: Wayne L. Ryan, John Scholl
  • Patent number: 6403377
    Abstract: Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems. The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, a nucleated red blood cell component, a platelet component and a reticulated platelet component. Methods of making and using the control compositions are also provided.
    Type: Grant
    Filed: August 21, 2001
    Date of Patent: June 11, 2002
    Assignee: Streck Laboratories, Inc.
    Inventors: Wayne L. Ryan, John Scholl
  • Patent number: 6403378
    Abstract: A kit for labeling cells to determine their viability which includes a first dye for labeling non-viable cells and a second dye for labeling all cells, including non-viable cells in which the dyes are selected to have concentrations suitable for determining the viability of cells in cell suspensions having different cell viability.
    Type: Grant
    Filed: April 26, 2001
    Date of Patent: June 11, 2002
    Assignee: Guava Technologies, Inc.
    Inventors: Janette T. Phi-Wilson, Don F. Rackham, Kevin M. Sheehan
  • Patent number: 6399388
    Abstract: Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems. The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, a nucleated red blood cell component, a platelet component and a reticulated platelet component. Methods of making and using the control compositions are also provided.
    Type: Grant
    Filed: December 19, 2000
    Date of Patent: June 4, 2002
    Assignee: Streck Laboratories, Inc.
    Inventors: Wayne L. Ryan, John Scholl
  • Publication number: 20020065334
    Abstract: A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase.
    Type: Application
    Filed: September 19, 2001
    Publication date: May 30, 2002
    Inventors: Michael A. Markowitz, Paul E. Schoen, Bruce P. Gaber, Banahalli R. Ratna, Paul R. Kust, David C. Turner, Douglas S. Clark, Jonathan S. Dordick
  • Patent number: 6376250
    Abstract: A visual indicating paste composition for detecting of aqueous solutions in hydrocarbons by changes in color. The paste is utilized by placing on a probe and inserting the probe in a storage device for fuel. Said paste comprising: a) a liquid carrier selected from high molecular weight polyols; b) a caustic powder selected from alkaline earth oxides; c) a gelling agent; d) a surfactant consisting of ethoxylated nonylphenol with 9 moles of ethylene oxide; e) a filler material. f) a water scavenger consisting of aluminum isopropoxide; g) an indicator dye; and h) a neutral dye; wherein the paste of the present invention will change color upon contact with an aqueous solution in the pH range of about between 7 and 11.
    Type: Grant
    Filed: August 17, 2000
    Date of Patent: April 23, 2002
    Inventor: Nabil J. Mohtadi
  • Publication number: 20020043651
    Abstract: The invention disclosed herein provides fluorescence based methods for the determination of polyhydroxylated analyte concentrations as well as optical polyhydroxylate analyte sensors and sensor systems. In particular, the invention provides methods of quantifying the abundances or concentrations of polyhydroxylate analyte by measuring changes in the fluorescence lifetimes. The methods of the invention are based on the observation that fluorescent sensor molecules capable of binding a polyhydroxylated analyte such as glucose have distinct fluorescent lifetimes depending upon whether they are in a form that is either bound to analyte or a form that is not bound to the analyte. The distinct and measurable differences in the fluorescence lifetimes of the different fluorescent sensor species can be used to determine the relative abundance of the bound and unbound fluorescent sensor species, a parameter which can then be correlated to the concentration of the analyte.
    Type: Application
    Filed: April 4, 2001
    Publication date: April 18, 2002
    Inventors: Christopher B. Darrow, Joe H. Satcher, Stephen M. Lane, Jennifer Harder Gable
  • Patent number: 6368864
    Abstract: A dye compound having the formula I: wherein, n is 0, 1, 2, or 3; R1 is H, alkyl, or an alkoxy group; R2 is CH2(CH2)mOH, wherein m is 0, 1, 2, or 3; X is O, S, or C(CH3)2; R is CH3, CH(CH3)2, CH2CH2OH, alkyl, alkylsulfonate, or hydroxyalkyl and B− is a counteranion. Red- and blue-excitable dyes based on the above chemical structure are described, and reagents containing them are described for use in staining nucleic acid, more particularly for staining reticulocytes. Also described are methods for detecting reticulocytes using such compositions.
    Type: Grant
    Filed: May 5, 2000
    Date of Patent: April 9, 2002
    Assignee: Coulter International Corp.
    Inventors: Chiranjit Deka, Song Y. Lee, Gene G.-Y. Shen, Stephen Szydlo, Tsong-Tseh Tsay, Ravinder Gupta
  • Patent number: 6357278
    Abstract: A sensor comprises a substrate and a polymeric film disposed on the substrate. The polymeric film comprises at least one hardblock component and at least one softblock component. The invention also sets forth a method for enhancing detection of a target compound by a sensor. The method comprises disposing a polymeric film on a surface of the sensor, in which the polymeric film enhances detection of target compounds not normally sensed by a sensor without the polymeric film. The polymeric film comprises at least one hardblock component and at least one softblock component.
    Type: Grant
    Filed: August 9, 1999
    Date of Patent: March 19, 2002
    Assignee: General Electric Company
    Inventors: Timothy Mark Sivavec, Radislav Alexandrovich Potyrailo
  • Patent number: 6358743
    Abstract: A carrier for contraband substances to be used as a reference for testing trace detection systems. The carrier, which has the consistency of hand cream and can be dispensed from a tube or a syringe, is inert with respect to the contraband substances and does not dissolve or degrade the plastics normally used for making luggage or computer disc cases. After the carrier (with added contraband substance) has been placed on a hard surface such as a plastic luggage handle and dried, the contraband substance can be sampled by wiping with a paper or cloth, which is then tested in a device that uses ion mobility spectrometry, gas chromatography, chemiluminescence, or a combination of these methods.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: March 19, 2002
    Assignee: The United States of America as represented by the Secretary of Transportation
    Inventor: Francis T. Fox
  • Patent number: 6352860
    Abstract: A tissue mimicking material for ultrasound phantoms has ultrasound speed and attenuation characteristics that are characteristic of human tissue and well suited for use in measuring and calibrating the potential biological effects of ultrasound equipment. The material is formed of an aqueous mixture of large organic water soluble molecules condensed from skim milk with a total solids content in the range of 10% to 30% by weight. The total fat content is less than 1% by weight, with the residual lipid particles of a size sufficiently small to remain in suspension without agglomerating and separating from the mixture over extended periods of time.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: March 5, 2002
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Ernest L. Madsen, Gary R. Frank
  • Publication number: 20020018512
    Abstract: A barrier for halogenated aromatic compounds is provided, especially fluorinated hydrocarbon films useful for containing precise quantities of halogenated aromatic compounds used as thermally sensitive materials in reversible chemical thermometers. A new shape of chemical thermometer is also disclosed.
    Type: Application
    Filed: July 1, 1998
    Publication date: February 14, 2002
    Applicant: 3M Innovative Properties Company
    Inventors: RODNEY K. HEHENBERGER, SARA L. MEGCHELSEN, RICHARD L. JACOBSON
  • Publication number: 20020018511
    Abstract: Helical arrays comprising structurally different chiral non-racemic molecules or molecular entities that control the helical sense of the helical array provide a method for temperature measurement with a unique characteristic in that the temperature dependent chiral biases of the competing structurally different chiral non-racemic entities control the helical sense population since these biases differ in their temperature dependence. By varying the composition of the chiral non-racemic entities, the temperature at which the helical sense population is equal and how the helical sense population varies as a function of temperature can be controlled. In this way, competing structurally different non-racemic chiral groups can be varied in their composition so that a helical array can be formed under their effect and be sensitive to temperature over a wide temperature range. In this way a temperature may be preselected so that a chiral optical property can reach a minimum near to zero at this temperature.
    Type: Application
    Filed: February 26, 2001
    Publication date: February 14, 2002
    Inventors: Mark M. Green, Jonathan V. Selinger
  • Publication number: 20020012610
    Abstract: The invention relates to a method of monitoring a sterilization process having an oxidation-type sterilant, said process comprising the steps of: providing an indicator compound capable of exhibiting a color change upon exposure to the sterilant, the indicator compound being free of heterocyclic nitrogen, diazo nitrogen and amino nitrogen, and selected from the group consisting of anthraquinone dyes, triarylmethane dyes and xanthene dyes; exposing the indicator compound to the sterilization process; and observing the compound for a change of colour. The invention also relates to an indicator for an ozone sterilization process. A preferred indicator compound is rosolic acid.
    Type: Application
    Filed: June 13, 2001
    Publication date: January 31, 2002
    Inventors: Sylvie Dufresne, Robert Boulay
  • Patent number: 6342391
    Abstract: A three-phase suspension suitable for use as an erythrocyte sedimentation rate (ESR) control having the following three components: (1) a synthetic plasma base, (2) an aggregating agent such as a high molecular weight polymer or combination of high molecular weight polymers, and (3) chemically fixed mammalian red blood cells. The control is designed to allow the user to monitor the accuracy and precision of analytical methods for determining the sedimentation rate of human erythrocytes in whole blood specimens. Chemical fixing of the red blood cells provides the ESR control with the capability of providing useful results in the presence of citrate and/or saline.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: January 29, 2002
    Assignees: Streck Laboratories, Inc., Hematronix Inc.
    Inventors: Roulhwai Chen, Azra S. Zaidi
  • Patent number: 6312644
    Abstract: Fluorescent monomers of the formula wherein M is selected from the group consisting of hydrogen, sodium, potassium, cesium, rubidium, lithium and ammonium, and n is selected from the group consisting of 1, 2, 3, 4, 6 and 9; are provided which are useful in the production of pyranine-tagged polymers which can be detected using a fluorometer and can be used in industrial water systems as treatment polymers.
    Type: Grant
    Filed: December 16, 1999
    Date of Patent: November 6, 2001
    Assignee: Nalco Chemical Company
    Inventors: Barbara E. Moriarty, Mingli Wei, John E. Hoots, David P. Workman, Jeffrey P. Rasimas
  • Patent number: 6310110
    Abstract: A method of making a molecularly imprinted porous structure makes use of a surfactant analog of the molecule to be imprinted that has the imprint molecule portion serving as the surfactant headgroup. The surfactant analog is allowed to self-assemble in a mixture to create at least one supramolecular structure having exposed imprint groups. The imprinted porous structure is formed by adding reactive monomers to the mixture and allowing the monomers to polymerize, with the supramolecular structure serving as a template. The resulting solid structure has a shape that is complementary to the shape of the supramolecular structure and has cavities that are the mirror image of the imprint group. Similarly, molecularly imprinted particles may be made by using the surfactant to create a water-in-oil microemulsion wherein the imprint groups are exposed to the water phase.
    Type: Grant
    Filed: July 30, 1999
    Date of Patent: October 30, 2001
    Inventors: Michael A. Markowitz, Paul E. Schoen, Bruce P. Gaber, Banahalli R. Ratna, Paul R. Kust, David C. Turner, Douglas S. Clark, Jonathan S. Dordick
  • Publication number: 20010032967
    Abstract: A temporary joint that includes a first discrete member having a first edge and a first movable coupling means; and a second discrete member having a second edge and a second movable coupling means. When it is necessary to form a joint between the first and second discrete members, the first and second edges are moved into abutment to define a binding edge. Then, the first and second movable coupling means are moved toward the binding edge; and the temporary joint is formed when the first and second movable coupling means are proximate the binding edge. The joint is broken by moving the first and second coupling means away from the binding edge. The first coupling means is comprised of a volume of a field responsive material and the second coupling means is a field producing means such as a magnet. A rigid joint is produced when the field producing supplies a field across the field responsive material.
    Type: Application
    Filed: April 20, 2001
    Publication date: October 25, 2001
    Applicant: Lord Corporation
    Inventors: J. David Carlson, Lynn C. Yanyo
  • Patent number: 6303046
    Abstract: New aerogels are disclosed which comprise silica, at least one organic polymer having polar functional groups, and at least one metal ion. Also disclosed are methods for making such aerogels and for making them as substantially transparent objects. In addition, gas detectors, liquid and gas absorbing objects, and optical devices made using these aerogels are disclosed. The present invention concerns optical elements which are substantially transparent and exhibit low refractive indices. The invention also relates to the optical properties of the metal-containing ions, the silica and polymer which they comprise. The optical elements can be passive or they can be active in response to electromagnetic radiation. The invention further relates to detectors of reactive and absorbate gases based on the physical changes exhibited by the aerogels upon reacting with or absorbing such gases.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: October 16, 2001
    Inventors: William M. Risen, Jr., Shuang Ji, Xiangjun Hu, Ruiyun Zhang
  • Patent number: 6300135
    Abstract: This invention has for its object to provide a blood component deposition-preventing agent and a blood coagulation accelerator, which are substantially indifferent to blood coagulation activity and serum chemistry parameters and a plastic blood test ware and a blood test matrix which do not confound measured values. The invention relates to a blood component deposition-preventing agent comprising a random copolymer of a monomer component (a) giving a water-soluble homopolymer and a monomer component (b) giving a water-insoluble homopolymer, a blood coagulation accelerator comprising a substantially blood-insoluble antimicrobial composition comprising a carrier and, as supported thereon, an antimicrobial metal, and a blood test ware or matrix carrying them on its inside wall or surface.
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: October 9, 2001
    Assignee: Sekisui Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hironobu Isogawa, Hideo Anraku
  • Patent number: 6294110
    Abstract: Two or more dyes or markers, including a dye or marker having an absorbance peak in the 400 to 500 nm range and including a dye or marker having an absorbance peak in the 560 to 700 nm range are mixed together in appropriate ratios so when added to a liquid, such as a petroleum fuel, at combined levels of from 5 to 100 ppm, the colors of the dyes and/or markers cancel each other such that a “water-white” liquid still appears “water-white”.
    Type: Grant
    Filed: November 18, 1999
    Date of Patent: September 25, 2001
    Assignee: Rohm and Haas Company
    Inventors: Michael R. Friswell, Al Zimin, Sr., Peter A. Caputo
  • Patent number: 6251680
    Abstract: Polymers having amine-thiol terminal moieties are provided. The amine-thiol terminal moieties are imparted by using amine-thiols as chain transfer agents in aqueous addition polymerizations. The polymers are useful as mineral dispersants, as water-treatment additives for boiler waters, cooling towers, reverse osmosis applications, sugar refining, paper production, geothermal processes and oil wells, and as detergent additives acting as builders, anti-filming agents, dispersants, sequestering agents and encrustation inhibitors.
    Type: Grant
    Filed: February 5, 1999
    Date of Patent: June 26, 2001
    Assignee: Rohm and Haas Company
    Inventors: Zhenwen Fu, Lorraine Holowach Keller, Barry Weinstein
  • Patent number: 6241912
    Abstract: An aqueous deformation-detecting brightener composition that can easily detect deformation such as unevenness on the surface of a car body by forming a liquid thin film having low foaming property and excellent glossiness is provided by dissolving a glycol ether compound expressed by the following formula (I) and a surfactant in water R1—O—(AO)m—R2  (I) where “R1” represents an alkyl group having 1 to 9 carbon atoms, an alkenyl group having 1 to 9 carbon atoms, an alkylphenyl group having 1 to 9 carbon atoms, or a functional group expressed by the following general formula (II), “A” represents an alkylene group having 2 to 4 carbon atoms, “m” represents an average adduct molar number of alkylene oxide, a number of 1 to 20, in which the same alkylene oxide may be added alone, or a mixture of two or more types of alkylene oxide may be added, and “R2” represents an alkyl group having 1 to 9 carbon atoms, an alkenyl group having 1 to 9
    Type: Grant
    Filed: October 28, 1997
    Date of Patent: June 5, 2001
    Assignees: Honda Giken Kogyo Kabushiki Kaisha, Lion Corporation
    Inventors: Yasuhiko Kitano, Akira Kodama, Hiroya Miyaoka, Hiroshi Hata, Naoki Kobayashi, Hisami Sasaki
  • Patent number: 6241385
    Abstract: A composition of matter suitable for use in a reversible thermometer is disclosed which comprises a thermally responsive material capable of being supercooled at least for several minutes, and subject to a change in state from a solid to a liquid substantially at a predetermined temperature; means for visually observing the change in state; and a matrix forming material comprising an amorphous organic compound, the matrix forming material being insoluble in the thermally responsive material; whereby the thermally responsive material is dispersed within the matrix forming material, the composition of matter being reversibly responsive to changes in temperature, and remaining in the liquid state for a time sufficient to permit a user of the composition to observe the change in state. The preferred matrix forming material is polyisobutylene, and the preferred thermally responsive material is a solid solution of ortho-chloronitrobenzene and ortho-bromonitrobenzene.
    Type: Grant
    Filed: June 8, 1998
    Date of Patent: June 5, 2001
    Assignee: 3M Innovative Properties Co
    Inventor: Craig R. Hof
  • Patent number: 6238595
    Abstract: A target for testing perforating systems, including an agglomeration of sand selected and conditioned to simulate a down-hole rock formation. A sand mixture may be selected to simulate the distributions of particle size, density and hardness of the down-hole rock formation. The sand may be agglomerated in the presence of a binding agent. Conditioning of the target may be conducted to simulate the compressive strength and porosity of the down-hole rock formation.
    Type: Grant
    Filed: February 17, 1998
    Date of Patent: May 29, 2001
    Assignee: Schlumberger Technology Corp.
    Inventors: James E. Brooks, Wenbo Yang
  • Patent number: 6225123
    Abstract: The present invention is an additive preparation for use in bodily fluid collection devices. The additive preparation has an additive, an organic acid and a metal carbonate compound. The preparation effervesces when in contact with a body fluid sample, thereby efficiently dispersing in a body fluid sample. The formulation is desirably tabulated to provide an effective, easily stored, and handled preparation. However, a binding or bulking agent may be added to the additive preparation formulation to provide binding and lubricating properties to the formulation. A binding agent enables granulating of the formulation without the forming of a pellet.
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: May 1, 2001
    Assignee: Becton Dickinson and Company
    Inventors: Richmond R. Cohen, Ajit N. Dastane
  • Patent number: 6225124
    Abstract: Aqueous blood-sample diluting reagent and method of its use for compelling a morphological change in a blood sample to yield an MCV value assayed at elapsed time after the sample is drawn to be consistent within a diagnostically acceptable range with the original, immediate post-drawing MCV value. Selection of a small amount of a predetermined surfactant added within a limited range of concentration, and of a salt for adjusting osmotic pressure of the sample is thereby determined. The blood sample is treated with an anti-coagulant agent immediately post-drawing, and for assay in a particle analyzer at post-drawing elapsed time is diluted with the reagent solution. The reagent has an osmotic pressure (&pgr;) of approximately 150-400 mOsm/kg and a pH of 6.0-8.5. The surfactant is present in a 0.0005% to 0.5% concentration and has a hydrophile-lipophile balance (HLB) of 10-20.
    Type: Grant
    Filed: June 2, 1999
    Date of Patent: May 1, 2001
    Assignee: Sysmex Corporation
    Inventors: Berend Houwen, Kinya Uchihashi, Yukio Hamaguchi, Rolf Mast
  • Patent number: 6221281
    Abstract: A liquid immersion oil which is used in optical systems in any of the fields of microscopes, fluorescence microscopes, optical measurements and other related fields includes a liquid polyolefine or a liquid copolymer of butylene (&agr;-butylene, &bgr;-butylene) and another olefine, blended with an aromatic compound, or blended with an aromatic compound and a paraffin compound.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: April 24, 2001
    Assignee: Nikon Corporation
    Inventor: Izumi Motoyama
  • Patent number: 6221668
    Abstract: Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems. The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, a nucleated red blood cell component, a platelet component and a reticulated platelet component. Methods of making and using the control compositions are also provided.
    Type: Grant
    Filed: February 16, 2000
    Date of Patent: April 24, 2001
    Assignee: Streck Laboratories, Inc.
    Inventors: Wayne L. Ryan, John Scholl
  • Patent number: 6214625
    Abstract: This invention relates to lytic reagents and methods of using the lytic reagents for automatically determining leukocyte subpopulations in blood. More specifically, the new lytic reagents selectively lyse red blood cells and certain leukocyte subpopulations, which enables the differentiation of at least one subpopulation of leukocytes. The lytic reagents contain an ethoxylated long chain amine, a quaternary ammonium salt and an acid. When used in combination with a second lytic reagent system, one is able to obtain at least a five part differential of leukocytes by impedance and light scatter measurements, by impedance and radio frequency measurements, or by radio frequency and light scatter measurements.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: April 10, 2001
    Assignee: Coulter International Corp.
    Inventors: Yi Li, Jing Li, Carole Jo Young
  • Patent number: 6210969
    Abstract: This invention relates to lytic reagents and methods of using the lytic reagents for automatically determining leukocyte subpopulations in blood. More specifically, the new lytic reagents selectively lyse red blood cells and certain leukocyte subpopulations, which enables the differentiation of at least one subpopulation of leukocytes. The lytic reagents contain a polyoxyethylene based surfactant, a quatemary ammonium salt and an acid. When used in combination with a second lytic reagent system, one is able to obtain at least a five part differential of leukocytes by impedance and light scatter measurements, by impedance and radio frequency measurements, or by radio frequency and light scatter measurements.
    Type: Grant
    Filed: April 28, 1999
    Date of Patent: April 3, 2001
    Assignee: Coulter International Corp.
    Inventors: Yi Li, Jing Li
  • Patent number: 6207080
    Abstract: A process for homogeneously dispersing at least one reactant in a fluid matrix, characterized in that capsules of a first type containing the reactant(s) are prepared with a first encapsulation product and capsules of a second type containing the fluid matrix are prepared with a second encapsulation product which is compatible with the first, these two types of capsules bearing electric charges of opposite polarity, the capsules of the two types are combined by electric attraction and the first and second encapsulation products are removed so as to obtain a composite material consisting of the fluid matrix containing the reactant(s) in homogeneous dispersion form, and products obtained according to this process.
    Type: Grant
    Filed: March 3, 1999
    Date of Patent: March 27, 2001
    Assignee: Aimco SA ( Automatic Instant Mesures et Controle Optique)
    Inventor: Philippe Guillot
  • Patent number: 6200500
    Abstract: Hematology control compositions and systems used to measure a plurality of parameters in a blood sample are provided. The hematology control compositions are particularly useful as a control for multi-parameter, automated instrument systems. The control compositions comprise a reticulocyte component, a white blood cell component, a red blood cell component, a nucleated red blood cell component, a platelet component and a reticulated platelet component. Methods of making and using the control compositions are also provided.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: March 13, 2001
    Assignee: Streck Laboratories, Inc.
    Inventor: Wayne L. Ryan
  • Patent number: 6194218
    Abstract: Blood samples are stabilized for methemoglobin determination with a buffer composition containing (a) carbon monoxide-containing water; (b) sodium tetraborate or potassium tetraborate; and (c) KCN or NaCN. The buffer composition preferably may also have an erythrocytolysis agent. The buffer fixes the valence state of heme iron at a concentration representative of the blood at the time of collection, and maintains that fixed state for an extended period of time preventing further methemoglobin formation. The buffer also prevents reduction of existing target analyte, i.e., methemoglobin (ferric hemoglobin, Fe3+ hemoglobin) to normal reduced hemoglobin (ferrous hemoglobin, Fe2+ hemoglobin).
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: February 27, 2001
    Assignee: The Fredric Rieders Family Renaissance Foundation
    Inventors: Fredric Rieders, Anthony J. Macherone
  • Patent number: 6177513
    Abstract: A method for evaluating an artificial receptor includes subjecting a functional monomer and a crosslinker in the presence of a template substance in a vessel into polymerization, thereby forming a resultant polymer with the template substance usually in the form of a thin film, dissociating the template substance from the polymer and removing it from the vessel by washing an inside of the vessel, thereby to prepare an artificial receptor, feeding a solution of the same or different template substance into the vessel to associate the template substance with the resulting polymer; then determining the amount of the template substance remaining in the vessel, and evaluating the artificial receptor on the basis of a determination result.
    Type: Grant
    Filed: March 12, 1999
    Date of Patent: January 23, 2001
    Assignees: Toshifumi Takeuchi, Sysmex Corporation
    Inventors: Toshifumi Takeuchi, Jun Matsui, Daigo Fukuma, Toshihiro Mizukami
  • Patent number: 6174731
    Abstract: A reagent for pH-metric acid number determination in a petroleum oil with low acid numbers (AN≦0.03 mg KOH/g oil) includes a salt of a strong base and a weak acid, and, an alkali in a mixture of water and an alcohol. The salt of a strong base and a weak is, preferably, sodium benzoate in a concentration of 0.02 to 0.1 M. The alcohol is, preferably, isopropanol in a concentration of from 50% to 80% by volume. The alkali is, preferably, an hydroxide and, most preferably, potassium hydroxide. The alkali should be adjusted to provide a pH′o, which is the pH of an equivalence-point on a titration curve of a strong acid added to a test portion of sodium benzoate, water and isopropanol.
    Type: Grant
    Filed: June 24, 1998
    Date of Patent: January 16, 2001
    Assignee: State of Israel, The Ministry of Industry and Trade, The National Physical Laboratory
    Inventors: Elena M. Strochkova, Yakov I. Tur'yan, Oleg Y. Berezin, Ilya Kuselman, Shenhar Avinoam