Nonreactive Analytical, Testing, Or Indicating Compositions Patents (Class 252/408.1)
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Patent number: 7202087Abstract: A solid heparin tablet composition has a melting point of 25° C. or higher and is a continuous lipid component containing one or more polar lipids, one or more non-polar lipids, optionally one or several of water and mono- to trivalent alcohol in an amount of up to 15% by weight of the composition, and native heparin or fractionated heparin. Also described is a corresponding tablet, processes for production of the composition and the tablet, and a method of preventing or treating conditions amenable to preventive or therapeutic treatment by administration of the tablet.Type: GrantFiled: June 12, 2003Date of Patent: April 10, 2007Assignee: LTP Lipid Technologies Provider ABInventors: Bengt Herslöf, Per Tingvall
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Patent number: 7192776Abstract: A synthetic urine solution and method of its manufacture are disclosed. The solution includes water having a pH between 3 and 10. The solution further includes creatinine and means for removing bacteria from the solution so as to control or eliminate sepsis of the urine solution, preferably through the use of biocide. The solution exhibits a specific gravity of from 1.005 g/cm3 to 1.025 g/cm3. Additional compounds may also be included to further enhance the aesthetics or apparent authenticity of the synthetic urine produced according to this invention.Type: GrantFiled: January 28, 2004Date of Patent: March 20, 2007Inventor: James Matthew Stephens
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Patent number: 7169615Abstract: Disclosed is a method of authenticating that a test polymer is an authenticatable polymer, wherein the authenticatable polymer has an authentication signal and comprises a substrate polymer and an optically variable tag, the optically variable tag having a fluorescence emission whose wavelength and/or intensity change over time, the method comprising subjecting the test polymer to a stimulus sufficient to cause fluorescence of the optically variable tag, determining a test signal from the fluorescence of the test polymer, and authenticating that the test polymer is an authenticatable polymer if the test signal is the same as the authentication signal of the authenticatable polymer.Type: GrantFiled: November 26, 2003Date of Patent: January 30, 2007Assignee: General Electric CompanyInventors: Vandita Pai-Paranjape, Radislav Potyrailo, Philippe Schottland
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Patent number: 7153403Abstract: A protein marker pellet for use in a gel electrophoresis system includes one or more protein markers including a protein of known molecular weight with ionic components to provide electrical conductance, and a non-protein, gel-forming material having a porosity sufficient to allow the one or more protein markers to migrate out of the protein marker pellet under the influence of an electrical field at the same rate as the ionic components.Type: GrantFiled: April 15, 2003Date of Patent: December 26, 2006Assignee: PageGel, Inc.Inventors: William F. Alpenfels, Patricia Marilu Vilalta
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Patent number: 7148067Abstract: A thromboplastin reagent includes tissue factor, Factor VIIa, and a net negatively charged phospholipid. The thromboplastin reagent is a synthetic thromboplastin reagent, and is in dried form.Type: GrantFiled: August 31, 2004Date of Patent: December 12, 2006Assignee: The Board of Trustees of the University of IllinoisInventors: James H. Morrissey, Stephanie A. Smith
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Patent number: 7144738Abstract: Methods for detecting biopolymers such as proteins, peptides, and nucleic acids in a matrix are provided, in which the methods include contacting the matrix with a sensitizing reagent that includes a substituted heteroaromatic compound; contacting the matrix with a reduceable metal salt to stain the biopolymer(s); and detecting the stained biopolymer(s). Compositions for performing the methods can include sensitizing agents, staining reagents, reducing agents, enhancing agents, and destaining agents. The compositions presented are compatible with mass spectrometry, and methods are provided for staining a biopolymer using the compositions of the invention and performing mass spectrometry on one or more biopolymers identified by the staining methods.Type: GrantFiled: March 31, 2005Date of Patent: December 5, 2006Inventor: Scott Whitney
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Patent number: 7141350Abstract: An article of manufacture has an environmental sensitive label with at least one cumulative time-temperature indicator and at least one thermal event indicator thereon. The cumulative time-temperature indicator and the thermal event indicator each provides an independent verification of product performance in a predetermined environment.Type: GrantFiled: September 22, 2003Date of Patent: November 28, 2006Assignee: Eastman Kodak CompanyInventor: Jeffrey L. Hall
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Patent number: 7141214Abstract: Water-based chemical indicator inks for ethylene oxide sterilization processes and methods for its use. The chemical indicator ink contains at least one pH indicator dye selected from the group consisting of Bromocresol green, Bromophenol blue, Methyl red, Ethyl orange, and combinations thereof. The pH indicator dye undergoes an irreversible color change when exposed to ethylene oxide vapor in the presence of low-temperature steam, but when exposed to other sterilization processes either does not undergo a color change or undergoes a color change that is different than is obtained when exposed to ethylene oxide.Type: GrantFiled: June 29, 2004Date of Patent: November 28, 2006Assignee: Illinois Tool Works Inc.Inventor: Shobha Shakher Puntambekar
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Patent number: 7094364Abstract: In one embodiment, a method for authenticating that a test polymer is an authenticatable polymer is disclosed wherein the authenticatable polymer comprises a substrate polymer and a thermochromic compound, the thermochromic compound having a first signal at a first temperature and at an authenticating wavelength, and a second signal at an authenticating temperature and the authenticating wavelength, the first and second signals being different, and the authenticating temperature being greater than the first temperature, the method comprising subjecting the test polymer to a stimulus sufficient to raise a portion of the test polymer to the authenticating temperature to create a heated portion, determining a test signal of the heated portion of the test polymer at the authenticating wavelength, and authenticating that the test polymer is an authenticatable polymer if the test signal is the same as an authenticating signal of the authenticatable polymer.Type: GrantFiled: November 26, 2003Date of Patent: August 22, 2006Assignee: General Electric CompanyInventors: Radislav Potyrailo, Philippe Schottland
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Patent number: 7060203Abstract: An electrolyte solution for a particle measuring apparatus which comprises an inorganic salt, such as sodium chloride or calcium chloride, dissolved in an organic solvent. A substance that promotes dissolution of inorganic salts is added to provide the organic solvent with sufficient electric conductivity for electrical particle measurement. Such substances include either or both: Compound (a): a zwitterionic compound or compounds, and Compound (b): a compound or compounds including a hydroxyl group and a carboxyl or an amino group in the same molecule.Type: GrantFiled: October 30, 2001Date of Patent: June 13, 2006Assignee: Sysmex CorporationInventor: Kouhei Shiba
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Patent number: 7059768Abstract: The invention provides a set of standards for accurately calibrating a vacuum thermogravimetric analyzer (VTGA). The invention solves the problem of calibrating a VTGA by using the actual magnetic transitions and associated transition temperatures, or Curie temperatures, TC's, of a set of standards which can be used in-situ at the location of the sample holder obviating the difficulties associated with indirect methods of calibration. The set of standards permits accurate calibration through sufficiently numerous calibration points over a rather limited low-temperature range for determining vapor pressures of compounds. The set of temperature calibration standards is fabricated from slugs of ferromagnetic material. The composition of the ferromagnetic material in each slug is altered by alloying a ferromagnetic constituent with a non-ferromagnetic constituent to provide a plurality of standards with different Curie temperature over the limited temperature range.Type: GrantFiled: March 21, 2005Date of Patent: June 13, 2006Assignee: Hitachi Global Storage Technologies NetherlandsInventors: Malika Dothresa Carter, Michael Andrew Parker
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Patent number: 7026110Abstract: The invention concerns a reagent for determination of leucocytes and measurement of haemoglobin in a sample of blood. This reagent comprises a buffer system that is suited to adjust selectively the pH of the reagent to an acidic value, at least one detergent of cationic type, a nitrogenous compound and, optionally, at least one inorganic salt. This reagent can be used in haematological analyses in human medicine and also permits the identification of a leucocytic subpopulation, in particular the basophil polymorphonuclear leucocytes.Type: GrantFiled: March 16, 2000Date of Patent: April 11, 2006Assignee: Horiba ABXInventors: Sylvie Veriac, Henri Champseix
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Patent number: 6939715Abstract: A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization.Type: GrantFiled: June 1, 2004Date of Patent: September 6, 2005Assignee: Chromaceutical Advanced Technologies, Inc.Inventors: Robert A. Beck, Robert A. Mateer, Jr.
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Patent number: 6933152Abstract: An artificial mixture which simulates human feces and its method of use for fecal occult blood testing as a control material or for proficiency testing are disclosed.Type: GrantFiled: March 31, 2004Date of Patent: August 23, 2005Assignee: NERL DiagnosticsInventor: Marshall E. Deutsch
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Patent number: 6929954Abstract: A method for separating and purifying the active hematinic species (AHS) present in iron-saccharidic compositions, including AHS such as sodium ferric gluconate complex, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function. The method separates the AHS from one or more excipients and, preferably, lyophilizes the separated AHS. Separation of the AHS permits its analytical quantification, further concentration, purification and/or lyophilization as well as preparation of new and useful products and pharmaceutical compositions.Type: GrantFiled: June 20, 2003Date of Patent: August 16, 2005Assignee: Chromaceutical Advanced Technologies, Inc.Inventors: Robert A. Beck, Robert A. Mateer
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Patent number: 6913932Abstract: A stabilization reagent composition, particularly desirable for stabilizing blood samples containing platelets, contains reactants that generate multiple species of formaldehyde-ammonium complexes; at least one inhibitor of phosphatase enzymatic activity; and at least one inhibitor of protease enzymatic activity. Blood samples and other tissues are stabilized by this composition. Such stabilized samples are produced by methods for stabilizing the tissue by contacting the sample with the composition.Type: GrantFiled: August 23, 2002Date of Patent: July 5, 2005Assignee: Beckman Coulter, Inc.Inventors: John A. Maples, Lori A. Charie, Daniel James Flagler, Rhonda Ann Mills, Richard Timmons
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Patent number: 6913928Abstract: Disclosed are hazardous chemical simulant compositions that can be used to simulate hazardous chemicals and methods for using hazardous chemical simulants. The compositions can include a phosphor, which emits visible light in the presence of ultraviolet light. The methods of using hazardous chemical simulants includes exposing a hazardous chemical simulant to special lighting conditions so that its location can be easily detected.Type: GrantFiled: April 8, 2002Date of Patent: July 5, 2005Assignee: Technical Solutions Group InternationalInventors: Nicholas L. Teta, David Brown, Michael Glass
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Patent number: 6899677Abstract: A coupling medium of a thin layer of a homogenized mixture of at least one polysaccharide or disaccharide such as trehalose; a surface-active substance such as sodium dioctylsulfosuccinate; and water acts as a coupling medium for transverse ultrasonic waves, when the homogenized mixture is applied to surfaces of a transmitting, respectively receiving, transducer for transverse ultrasonic waves; and a surface of a probe.Type: GrantFiled: August 22, 2000Date of Patent: May 31, 2005Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Frank Volke, Jürgen Meiche
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Patent number: 6900058Abstract: An aqueous control solution is disclosed for use with a spectrophotometer or photometric test strip that includes a predetermined amount of an analyte, a hydrophobic reference dye and a surfactant. In one embodiment, the aqueous control solution is applied to a photometric test strip having a chemical that oxidizes glucose and consequently forms hydrogen peroxide which reacts with an indicator dye that is also present on the strip. In this embodiment, the control solution includes a predetermined amount of glucose, an infrared reference dye, sodium dodecyl sulfate, and the indicator dye, such as sulforhodamine B.Type: GrantFiled: March 11, 2003Date of Patent: May 31, 2005Assignee: Bionostics, Inc.Inventors: Minna A. Rannikko, Donna M. Murray, Donna M. Rafferty
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Patent number: 6878551Abstract: The present invention relates to a method for detecting biopolymers in a matrix, which includes contacting the matrix with a sensitizing reagent including on one or more optionally substituted heteroaromatic compounds; contacting the matrix with one or more reduceable metal salts to stain the biopolymer; and detecting the stained biopolymer. The invention also relates to compositions for carrying out the invention and compositions made according to the invention. The invention also relates to kits for carrying out the methods of the invention.Type: GrantFiled: August 27, 2003Date of Patent: April 12, 2005Assignee: Invitrogen CorporationInventor: Scott Whitney
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Patent number: 6875373Abstract: A composition for use in testing smoke detectors, comprises a polyhydroxy alcohol and a surface-active agent.Type: GrantFiled: March 14, 2002Date of Patent: April 5, 2005Assignee: No-Climb Products Ltd.Inventor: Chinwe Elendu
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Patent number: 6871998Abstract: The invention provides a method for accurately calibrating a vacuum thermogravimetric analyzer (VTGA). The invention solves the problem of calibrating a VTGA by using the actual magnetic transitions and associated transition temperatures, or Curie temperatures, Tc's, of a set of standards which can be used in-situ at the location of the sample holder obviating the difficulties associated with indirect methods of calibration. The invention encompasses a method of using a set of calibration standards comprised of a plurality of ferromagnetic slugs to provide a temperature calibration for a VTGA. The method permits accurate calibration through sufficiently numerous calibration points over a rather limited low-temperature range for determining vapor pressures of compounds. Through the use of these standards, highly accurate measurements can be made of the vapor pressures of critical hard disk drive compounds, such as lubricants, and corrosion inhibitors, that are crucial to competitive disk drive technology.Type: GrantFiled: August 1, 2003Date of Patent: March 29, 2005Assignee: Hitachi Global Storage Technologies Netherlands B.V.Inventors: Malika Dothresa Carter, Michael Andrew Parker
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Patent number: 6869798Abstract: A lytic reagent composition and the method of use for differential analysis of leukocytes using flow cytometry are disclosed. The lytic reagent composition includes a short chain alkyl oxyethanol, such as 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol, or 2-isopropoxyethanol, in a sufficient amount to preserve leukocytes; a non-lysing nonionic surfactant as a debris solublizer; and an inorganic buffer to maintain pH of the lytic reagent composition in a range from 9.1 to 10.7. The lytic reagent composition is used to lyse red blood cells and preserve leukocytes, as well as used as the sheath reagent for the focus flow measurement. The lytic reagent composition, when used on a flow cytometric analyzer with multiple angle light scatter and light absorbance measurements, enables differentiation of leukocytes into five subpopulations.Type: GrantFiled: April 17, 2003Date of Patent: March 22, 2005Assignee: Clinical Diagnostics Solutions, Inc.Inventors: Harold Richardson Crews, Michael N. Elliott, James Harrison Carter, II
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Patent number: 6858432Abstract: Automated staining equipment that can mix reagents is used to spray a Romanowsky stain onto slide mounted specimens which are then briefly centrifuged. The centrifugation step removes excess stain leaving only a thin film. Depending on the time of the centrifugation step, most of the organic solvent and part of the water in the stain are evaporated by airflow through the equipment. This greatly accelerates the staining reaction and preserves water soluble structures such as the granules in basophilic leukocytes. For optimal performance, this staining procedure requires a thiazin-eosin stain with about 90% to about 40% organic solvent, such as methanol, and only about 10% to about 60% water. This is a unique staining reagent in Romanowsky staining.Type: GrantFiled: August 29, 2002Date of Patent: February 22, 2005Assignee: Wescor, Inc.Inventors: Barry O. Stokes, Patti A. Nelson, Gary D. Bradshaw
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Patent number: 6855552Abstract: The present invention provides reagents for use in an automated environment for cell conditioning of biological samples wherein the cells or tissues are predisposed for access by reagent molecules for histochemical and cytochemical staining procedures. The components of the reagents are optimized to facilitate molecular access to cells and cell constituents within the biological sample. The present invention also provides reagents for use in an automated environment for removing or etching embedding media by exposing a biological sample to be stained in histochemical or cytochemical procedures without the dependence on organic solvents. The components of the reagents are optimized to facilitate removal or etching of the embedding media from the biological sample.Type: GrantFiled: March 7, 2001Date of Patent: February 15, 2005Assignee: Ventana Medical SystemsInventors: Penny Towne, Joseph Utermohlen, Chad Wilkinson, Paula Rodgers, Kimberly Christensen, Ethel Macrea, Noemi Sebastiao
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Patent number: 6846678Abstract: The present invention provides storage stable, aseptic buffer solutions suitable for gamma sterilization. The buffer solutions include benzethonium chloride as a biocide, and avoid the acidification effects and the formation of precipitates that can be caused by gamma sterilization.Type: GrantFiled: November 25, 2003Date of Patent: January 25, 2005Assignee: Terumo Cardiovascular Systems, Co.-TustinInventors: Matthew Romey, Mark Takagi
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Publication number: 20040265170Abstract: The present invention provides a hydrogen peroxide indicator that includes a substrate on which is disposed an indicator composition that includes at least one of a select group of colorants. As a result of contact with hydrogen peroxide, the colorants change color, and even become colorless, thereby providing an indication of the presence of hydrogen peroxide.Type: ApplicationFiled: July 14, 2004Publication date: December 30, 2004Applicant: 3M Innovative Properties CompanyInventor: David M. Read
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Patent number: 6830707Abstract: A temperature indicating material of the present invention includes at least an electron donating compound, an electron accepting compound, a reversible material causing reversible transformation between crystal and amorphous states, or reversible transformation between phase separation and non-phase-separation, with respect to a part or all of the composition system; and a temperature characteristic controller having a solid-state in room temperature and at least a part of the temperature characteristic controller dissolves in the electron accepting compound, the reversible material, or the electron accepting compound and the reversible material so as to change the speed of the reversible transformation between crystal and amorphous, or speed of the reversible transformation between phase separation and non-phase-separation, with respect to the composition system, by its reversible transformation between crystal and amorphous states, or the speed of the reversible transformation between phase separation andType: GrantFiled: June 6, 2001Date of Patent: December 14, 2004Assignee: Toshiba Tec Kabushiki KaishaInventors: Toshiyuki Tamura, Takayuki Hiyoshi, Yuichiro Hatanaka
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Patent number: 6821789Abstract: A collection container and method for collecting a predetermined volume of a biological sample, and particularly a whole blood sample, includes at least one gene induction blocking agent in an amount effective to stabilize and inhibit gene induction. The gene induction blocking agent is able to stabilize nucleic acids in the biological sample at the point of collection to block ex vivo gene induction in the sample when stored at room temperature. The stabilizing agents include cationic compounds, detergents, particularly cationic detergents, chaotropic salts, ribonuclease inhibitors, chelating agents, organic solvents, organic reducing reagents, and mixtures thereof. The biological sample is collected directly from the animal and immediately mixed with the gene induction blocking agent without any intermediate processing or handling.Type: GrantFiled: July 2, 2003Date of Patent: November 23, 2004Assignee: Becton, Dickinson and CompanyInventors: Frank A. Augello, Lynne Rainen, Matthew Walenciak, Uwe Oelmüller, Ralf Wyrich, Helge Bastian
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Patent number: 6811575Abstract: Method for invisibly marking a liquid petroleum hydrocarbon. The method comprises adding to the liquid petroleum hydrocarbon at least one dye selected from the group consisting of 1,4,5,8-tetrasubstituted anthraquinones and anthraquinone dimers. The absorption maximum of the dye(s) is in the range from 710 nm to 850 nm.Type: GrantFiled: December 3, 2002Date of Patent: November 2, 2004Assignee: Rohm and Haas CompanyInventors: Kim Sang Ho, Yu-Min Chen
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Publication number: 20040211940Abstract: The present invention provides a method for the measurement of the activity of a plasminogen activator, such as urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) in a biological sample using an assay method characterized by the inclusion of an elastase inhibitor in the assay mixture. The invention also provides a diagnostic kit for the measurement of a plasminogen activator using said method and a method of determining the effective therapeutic dose of a plasminogen activator inhibitor using said method. Also provided is a method of preparing a pharmaceutical composition.Type: ApplicationFiled: May 17, 2002Publication date: October 28, 2004Applicant: AstraZeneca ABInventors: Paul Elvin, Philip Edwin Pinder
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Publication number: 20040187564Abstract: Additives such as chemical elements, microstructures, time degradable molecules, micro oscillators (clocks) etc. are introduced into inks at production. The additives can be analyzed in samples thus giving source of and date of production. By varying additives over short time spans estimates of date of use may be obtained.Type: ApplicationFiled: January 29, 2004Publication date: September 30, 2004Inventor: Jon C. Hagerty
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Patent number: 6790411Abstract: The present invention provides a hydrogen peroxide indicator that includes a substrate on which is disposed an indicator composition that includes at least one of a select group of colorants. As a result of contact with hydrogen peroxide, the colorants change color, and even become colorless, thereby providing an indication of the presence of hydrogen peroxide.Type: GrantFiled: December 2, 1999Date of Patent: September 14, 2004Assignee: 3M Innovative Properties CompanyInventor: David M. Read
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Publication number: 20040162374Abstract: A marker paint comprises 42 wt % to 52 wt % pigment, 31 wt % to 37 wt % acrylic resin and 17 wt % to 21 wt % silicone resin excluding solvent. The pigment comprises cobalt titanium oxide, titanium nickel antimony oxide, cobalt aluminium oxide or cadmium sulphide selenium to give a green, yellow, blue or red colour respectively. The marker paint is used in conjunction with an irreversible temperature indicating paint to determine if there is any debris and/or dirt on the irreversible temperature indicating paint to affect the accuracy of the temperature measurement of the irreversible temperature indicating paint.Type: ApplicationFiled: January 21, 2004Publication date: August 19, 2004Applicant: ROLLS-ROYCE PLCInventors: Hugh M.L. Watson, Elaine C. Hodgkinson
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Patent number: 6777240Abstract: The invention provides a class of samples that model the human body. This family of samples is based upon emulsions of oil in water with lecithin acting as the emulsifier. These solutions that have varying particle sizes may be spiked with basis set components (albumin, urea and glucose) to simulate skin tissues further. The family of samples is such that other organic compounds such as collagen, elastin, globulin and bilirubin may be added, as can salts such as Na+, K+and Cl−. Layers of varying thickness with known index of refraction and particle size distributions may be generated using simple crosslinking reagents, such as collagen (gelatin). The resulting samples are flexible in each analyte's concentration and match the skin layers of the body in terms of the samples reduced scattering and absorption coefficients, &mgr;'s and &mgr;a. This family of samples is provided for use in the medical field where lasers and spectroscopy based analyzers are used in treatment of the body.Type: GrantFiled: September 11, 2002Date of Patent: August 17, 2004Assignee: Sensys Medical, Inc.Inventors: Kevin H. Hazen, James Matthew Welch, Stephen F. Malin, Timothy L. Ruchti, Alexander D. Lorenz, Tamara L. Troy, Suresh Thennadil, Thomas B. Blank
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Patent number: 6773637Abstract: The present invention is directed to a thermochromic temperature sensitive composition used to detect the prevailing temperature, and particularly, to detect when the temperature is within a particular range. When the temperature is within that range, the composition undergoes a color change that is visible to the observer.Type: GrantFiled: May 1, 2000Date of Patent: August 10, 2004Inventors: Gail D. DiSalvo, John Cusick
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Patent number: 6773924Abstract: A method for separating and purifying the active hematinic species present in iron-saccharidic complexes including sodium ferric gluconate complex in sucrose, ferric hydroxide-sucrose complex and ferric saccharate complex and others of similar form and function, based on separation of the iron-saccharidic complex from one or more excipients and, preferably, lyophilization. Separation of the iron-saccharidic complex permits its analytical quantification; further concentration or purification as a new and useful product; preparation of redesigned formulations for new and useful pharmaceuticals; and/or lyophilization.Type: GrantFiled: February 21, 2003Date of Patent: August 10, 2004Assignee: Chromaceutical Advanced Technologies, Inc.Inventors: Robert A. Beck, Robert A. Mateer, Jr.
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Patent number: 6770220Abstract: Luminescent microparticles and nanoparticles are provided for use either as internal standards for referencing fluorescent signals, or as markers for detecting biomolecules. Luminescence dyes are incorporated in inert form into solid materials such that they are protected from the influence of chemical and biological compounds in aqueous sample constituents. The photophysical characteristics of the dyes (spectral characteristics, luminescence quantum efficiency, luminescence fading time and polarization) remain unaffected. The surface of the nanoparticles and microparticles can be provided with reactive surfaces in order to enable covalent coupling of biochemicals or to eliminate aggregation.Type: GrantFiled: January 15, 2002Date of Patent: August 3, 2004Assignee: Presens Precision Sensing GmbHInventor: Ingo Klimant
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Publication number: 20040135125Abstract: Fluorescent monomers are described and claimed which are synthesized by reacting a substituted or non-substituted naphthalic anhydride with an amine and with a moiety containing a polymerizable group. Such monomers are useful for the preparation of tagged treatment polymers. Such tagged treatment polymers are useful as scale inhibitors in industrial water systems.Type: ApplicationFiled: September 9, 2003Publication date: July 15, 2004Inventors: John D. Morris, Barbara E. Moriarty, Mingli Wei, Patrick G. Murray, Jerry L. Reddinger
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Publication number: 20040135124Abstract: Fluorescent monomers are described and claimed which are synthesized by reacting a substituted or non-substituted naphthalic anhydride with an amine and with a moiety containing a polymerizable group. Such monomers are useful for the preparation of tagged treatment polymers. Such tagged treatment polymers are useful as scale inhibitors in industrial water systems.Type: ApplicationFiled: September 9, 2003Publication date: July 15, 2004Inventors: John D. Morris, Barbara E. Moriarty, Mingli Wei, Patrick G. Murray, Jerry L. Reddinger
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Patent number: 6759246Abstract: A control composition, and method of preparing a control composition, that includes stabilized, mammalian granulocytes having altered physical properties so that the granulocytes function as a human lymphocyte analogs when used on an automated blood cell analyzer.Type: GrantFiled: November 30, 2001Date of Patent: July 6, 2004Assignee: Research & Diagnostic Systems, Inc.Inventor: Mark Collins
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Patent number: 6750756Abstract: A method for associating information with an article, an isotopic labeling composition to label an article with information using at least two different isotopes of an element, and an article labeled with the labeling composition. In the labeling composition, the isotopes of the labeling composition have an abundance ratio that is detectably different from the natural abundance ratio thereof. By detecting the abundance ratio(s) of the isotopes in the labeling composition, via laser ablation/magnetic spectroscopy, an NQR spectrometer, an NMR spectrometer, an IR spectrometer, or a microwave spectrometer, information about the article can be determined. The method and labeling composition may be used to identify, authenticate or determine the source or origin of an article or to provide detailed information about an article.Type: GrantFiled: August 7, 2002Date of Patent: June 15, 2004Assignee: Theragenics CorporationInventors: Nigel R. Stevenson, John M. Dawson, Lee Heflinger
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Publication number: 20040107765Abstract: A surface acoustic wave gas sensor for detecting predetermined substances includes a piezoelectric substrate, an input transducer and an output transducer which is formed on the piezoelectric substrate, and a sensitive film which is formed between the input transducer and the output transducer and detects at least one of acetone, benzene, dichloroethane, ethanol, and toluene. The sensitive film includes mercaptoundecanoic acid and CMP composed of cellulose nitrate, dibutyl phthalate, compound of benzene and ethanol, ethyl acetate. The surface acoustic wave gas sensor can quickly detect even small amounts of these substances.Type: ApplicationFiled: December 3, 2003Publication date: June 10, 2004Inventors: Kun-Hyung Lee, Jung-Sung Hwang, Seung-Yeon Cho
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Patent number: 6746630Abstract: The claims are drawn to a method of detecting seal breakage or incomplete seal formation in a package, said method comprising the steps of: (i) providing said package, prior to sealing, with a strip or ring of an indicator comprising an oxygen scavenging composition which includes a source of labile hydrogen or electrons and at least one reducible organic compound, wherein said strip or ring is located on an internal surface adjacent to where a seal is to be formed, (ii) treating the strip or ring with electromagnetic energy so as to reduce the reducible organic compound to a reduced form which is oxidizable by ground state molecular oxygen regardless of the presence of a transition metal catalyst and such that, when oxidized, there is a detectable change in a characteristic of said composition selected from the group consisting of: colour, fluorescence emission and UV-visible, infrared or near-infrared absorption, (iii) subjecting said package to a sealing process intended to seal the package, and (iv) detecType: GrantFiled: January 17, 2003Date of Patent: June 8, 2004Assignee: Commonwealth Scientific and Industrial Research OrganisationInventor: Michael Laurence Rooney
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Publication number: 20040089847Abstract: The invention relates to a stain solution, which is devoid of phenol, for staining bacteria. Said solution contains at least one dye, one solvent and one of the following substances, or mixtures thereof, as a phenol substitute: 2-butoxy thylacetate, 2-phenylethanol, benzyl alcohol, 4-methoxyphenol or cyclohexanol.Type: ApplicationFiled: November 14, 2002Publication date: May 13, 2004Inventors: Andreas Rauh, Daniela Grabis, Evangelos Thomas, Dorothee Meier
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Publication number: 20040082070Abstract: Systems and methods for establishing and/or maintaining the accuracy of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to reduce the effect of instrument or environment variation on the measurement capability of the model. The optically similar reference can be a gel composition having scattering particles suspended therein. The reference gel can be directly applied to a spectroscopic instrument sampler, or can be in a container specifically designed for optimal coupling to a spectroscopic instrument.Type: ApplicationFiled: October 28, 2002Publication date: April 29, 2004Inventors: Howland D. T. Jones, David J. Nunez, Stephen J. Vanslyke, Robert D. Johnson, Edward L. Hull
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Publication number: 20040067591Abstract: Tissue mimicking materials for elastography phantoms have elastic, ultrasound, and magnetic resonance characteristics that are characteristic of human soft tissues and well suited for the calibration and performance assessment of elastography imaging systems. In one embodiment, the material is formed from a base material containing an oil dispersed within a gel matrix and at least one inclusion formed from a gel. In another embodiment, the material is formed from a gel-forming material suffused throughout an open-cell reticulated mesh matrix.Type: ApplicationFiled: October 4, 2002Publication date: April 8, 2004Applicant: Wisconsin Alumni Research FoundationInventors: Ernest L. Madsen, Gary R. Frank
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Patent number: 6712996Abstract: The invention relates to temperature indicating compositions which display temperature dependent color changes. The invention encompasses temperature indicating compositions, materials, devices and methods of their use. The temperature indicating compositions of the invention are clays that can be used to detect temperature and temperature changes at sub-ambient and particularly sub-zero ° C. temperatures. Temperature of a selected environment can be monitored by placing a temperature-sensitive composition comprising the clay material of this invention in contact with that environment and monitoring the color of the composition.Type: GrantFiled: June 19, 2001Date of Patent: March 30, 2004Inventors: Jun Wu, Yaomin Xia, Joseph W. Stucki
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Publication number: 20040051081Abstract: An indicating desiccant comprises a silica-based material having impregnated thereon a source of copper and a source of bromide, the source of copper being present in an amount up to 0.5 per cent by weight, calculated as Cu with respect to weight of the silica-based material, and the source of bromide being present in an amount such that the weight ration of Br to Cu is at least 5:1. Optionally, the indicating desiccant also comprises a dye or other coloured material.Type: ApplicationFiled: July 17, 2003Publication date: March 18, 2004Inventor: Stephen Moreton
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Patent number: 6706526Abstract: A low formaldehyde containing aqueous blood diluent contains an effective amount of ethylenediamine tetraacetic acid, ethylenediamine tetraacetic acid derivative, or combinations thereof; an effective amount of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one; and an effective amount of 5-bromo-5-nitro-1,3-dioxane. Advantageously, less than about 1 parts per million of formaldehyde is produced in this multipurpose diluent. A method of analyzing a blood sample containing blood cells is conducted by forming a diluted blood sample by mixing a blood sample containing blood cells with this diluent and analyzing the diluted blood sample to determine a physical parameter of the blood cells.Type: GrantFiled: January 24, 2002Date of Patent: March 16, 2004Assignee: Coulter International Corp.Inventors: Russell F. Lang, Iris L. Payan, Barbara G. Murza, Luisa C. Oramas