Abstract: Solid, stable formulations of linaclotide suitable for oral administration are described herein as are methods for preparing such formulations. The formulations described herein contain a polypeptide consisting of the amino acid sequence Cys Cys Glu Tyr Cys Cys Asn Pro Ala Cys Thr Gly Cys Tyr (“linaclotide”; SEQ ID NO:1) or a pharmaceutically acceptable salt thereof. The linaclotide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.

Abstract: Disclosed are novel pharmaceutical compositions containing N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide dimethyl sulfoxide solvate, methods of using the compositions in therapy and processes for preparing the same.

Abstract: In a process for producing a hearing aid, comprising a housing made out, at least partially, of a metallic or ceramic part using powder injection molding technique (PIM) within the housing (1) at least one additional element (3) made out of a polymeric material is arranged for placing functional parts (5, 7, 13) within or at the housing (1) to reduce complexity of P parts and/or to compensate any tolerances due to the PIM process.

Abstract: A process produces a polylolefin-based resin expanded beads molded article that is excellent in bending deflection characteristics, high in porosity, low in bulk density and light in weight, and has interconnected void spaces. The process comprises filling, in a mold cavity, multi-layered polylolefin-based resin expanded beads each of which has a cylindrical, polylolefin-based resin expanded core layer and a polylolefin-based resin outer layer covering the expanded core layer and which satisfy specific requirements, introducing steam in the mold cavity to heat the multi-layered expanded beads filled in the mold cavity to fuse bond and mold the multi-layered expanded beads in the mold cavity.

Abstract: The present invention relates to pharmaceutical dosage forms, for example to a tamper resistant dosage form including an opioid analgesic, and processes of manufacture, uses, and methods of treatment thereof.

Abstract: An inverted microwell (102) provides rapid and efficient microanalysis system (100) and method for screening of biological particles (128), particularly functional analysis of cells on a single cell basis. The use of an inverted open microwell system (102) permits identification of particles, cells, and biomolecules that may be combined to produce a desired functional effect also functional screening of secreted antibody therapeutic activity as well as the potential to recover cells and fluid, and optionally expand cells, such as antibody secreting cells, within the same microwell.

Abstract: Disclosed is a method of consolidating a powder. The method can include obtaining a powder of semiconductor nanocrystals, obtaining a material which will form a gas when heated, and combining the powder and the material into a combined powder. The method can also include consolidating the powder by applying heat and pressure to the combined powder.

Abstract: Provided is a method of producing a friction material that can prevent occurrence of dust generation and segregation at the time of mixing raw materials of the friction material and that is resistant to deterioration of the friction material even when a phenol resin is employed as a binder and that also allows the production process to be effected safely and speedily and at a low cost. The method includes a mixing step (A) for stirring the raw materials for the friction material containing a high-ortho phenol resin, slaked lime and 3-10 wt. % of water and a forming step (B) for forming a mixture powder obtained from the mixing step (A) to a desired shape at room temperature.

Abstract: A process for producing geometric shaped catalyst bodies K whose active material is a multielement oxide which comprises the element Mo, the elements Bi and/or V and one or more of the elements Co, Ni, Fe, Cu and alkali metals, in which sources of the different elements are used to obtain a finely divided mixture which is coarsened to a powder by press agglomeration, the coarsened powder is used to form, by press agglomeration, shaped bodies V which are separated into undamaged shaped bodies V+ and into damaged shaped bodies V?, the undamaged shaped bodies V+ are converted by thermal treatment to the shaped catalyst bodies K, and the damaged shaped bodies V? are comminuted and recycled into the obtaining of the finely divided mixture.

Abstract: The present invention relates to a pharmaceutical dosage form containing the active substance BIBW 2992 as the dimaleate salt, providing an immediate release profile of the active substance, further, the invention relates to compacted intermediates comprising BIBW 2992 dimaleate salt (BIBW 2992 MA2) in form of a powder prepared using a combined roller compaction and sieving step from BIBW 2992 MA2, intermediate blends prepared from said compacted intermediate as well as solid oral formulations providing an immediate release profile of the active substance, made from said compacted intermediate or from said intermediate blends ready for use/ingestion, e.g. capsule and tablet formulations such as uncoated or film-coated tablets prepared by direct-compression, and methods for their production.

Abstract: A filter comprising a pad of non-woven fibrous material, the pad having a substantially solid edge of consolidated pad material which has been softened and subsequently hardened.

Abstract: A photovoltaic device includes an electron accepting material and an electron donating material. One of the electron accepting or donating materials is configured and dimensioned as a first component of a bulk heterojunction with a predetermined array of first structures, each first structure is substantially equivalent in three dimensional shape, has a substantially equivalent cross-sectional dimension, and where each first structure of the array of first structures has a substantially equivalent orientation with respect to adjacent first structures of the predetermined array forming a substantially uniform array.

Abstract: A method for creating a three-dimensional solid freeform fabrication object includes spreading a reactive powder on a substrate, selectively dispensing a core binder in the reactive powder to form a core material, and selectively dispensing a shell binder in the reactive powder to form a shell on the core material.

Abstract: Solid dosage forms of methylthioninium chloride (MTC) further comprise at least one diluent suitable for direct compression. The MTC exists in a substantially pure and stable polymorphic form. The solid dosage forms may preferably be prepared by direct compression methods.

Abstract: A three-dimensional shaping method includes forming a combination to be each level of a three-dimensional shaped object and also forming a combination to be each level of a shaped object support member in each of a plurality of powder material layers having an uncured powder material in accordance with hierarchical shape data corresponding to each of the powder material layers.

Abstract: A sputtering target comprises a low Tg glass or an oxide of copper or tin. Such target materials can be used to form mechanically-stable thin films that exhibit a self-passivating phenomenon and which can be used to seal sensitive workpieces from exposure to air or moisture. Low Tg glass materials may include phosphate glasses such as tin phosphates and tin fluorophosphates, borate glasses, tellurite glasses and chalcogenide glasses, as well as combinations thereof.

Abstract: This oxide sintered compact is obtained by mixing and sintering powders of zinc oxide, tin oxide and indium oxide. As determined by X-ray diffractometry of this oxide sintered compact, the oxide sintered compact has a Zn2SnO4 phase as the main phase and contains an In/In2O3—ZnSnO3 solid solution wherein In and/or In2O3 is solid-solved in ZnSnO3, but a ZnxInyOz phase (wherein x, y and z each represents an arbitrary positive integer) is not detected. Consequently, the present invention was able to provide an oxide sintered compact which is suitable for use in the production of an oxide semiconductor film for display devices and has both high electrical conductivity and high relative density. The oxide sintered compact is capable of forming an oxide semiconductor film that has high carrier mobility.

Abstract: The invention solves the problem of the manner of obtainment of mass for production of shaped construction elements. The manner consists of the fact, that in the mechanical mixer a ceramic granulate is placed, preferably in the form of pearlite and is soaked, preferably with water until complete soaking of the granulate and is mixed with the binding agent until obtainment of the situation, where each loose grain (1) of the granulate is coated with a layer of moist binding agent, creating a coating (2) around the grain. Priorly prepared moulds are filled with the obtained mass. The mass for production of shaped construction elements consists of 15-25% of bond weight, preferably in the form of pearlite, 35-45% of binding agent weight, preferably in the form of plaster with improved resistance parameters and 35-45% of water weight.

Abstract: The invention relates to dry processes for producing oral dosage forms, more specifically tablets, comprising atazanavir and adhesion enhancers. The invention further relates to compacted intermediates comprising atazanavir and adhesion enhancers.

Abstract: An animal litter, process for preparing the animal litter and a method for removal of animal waste using the animal litter are provided. The animal litter generally includes at least about 10 weight % finely ground pine wood powder. Further the animal litter includes a lubricant and a cohesiveness agent. The animal litter is in the form of discrete plural particles which tend to agglomerate when wetted.

Abstract: Process for the production of a molding from particulate and/or fibrous substrates based on renewable raw materials and a formaldehyde-free, aqueous binder.

Abstract: Aqueous binder composition for granular and/or fibrous substrates

Abstract: A method of production of ethylene-based polymer particles includes the steps of: homopolymerizing ethylene or copolymerizing ethylene and a linear or branched ?-olefin having 3 to 20 carbon atoms in the presence of an olefin polymerization catalyst including: (A) fine particles having an average particle diameter greater than or equal to 1 nm and less than or equal to 300 nm obtained at least by the following two steps: (Step 1) causing contact between a metal halide and an alcohol in a hydrocarbon solvent; (Step 2) causing contact between a component obtained by (Step 1) and an organoaluminum compound and/or an organoaluminumoxy compound; and (B) a transition metal compound represented in General Formula (I) or (II), and (E) an intrinsic viscosity [?] of the ethylene-based polymer particles, measured in decalin at 135° C., is from 5 to 50 dL/g.

Abstract: Provided are porous, biocompatible implant bodies and materials. These materials suitably comprise a population of randomly arranged thermoplastic constituents, with at least some of the constituents being bonded to one another The implant bodies are capable of being manipulated at room temperature from a first shape to a second shape, and of maintaining the second shape at about internal body temperature. Also provided are related methods of fabricating such implants and installing the implants into a subject.

Abstract: Disclosed are a carbon nanomaterial pellet and a method for preparing same. More particularly, it relates to a carbon nanomaterial pellet having a specific size and a high apparent density prepared by a simple process using only a rotary tablet press without mixing a carbon nanomaterial powder with a solvent or an additive, which is capable of solving the powder dust problem occurring when preparing a polymer composite from a carbon nanomaterial in the form of powder, thus improving physical properties and remarkably reducing cost of packaging and transportation, and a method for preparing the carbon nanomaterial pellet from a carbon nanomaterial powder.

Abstract: The present invention relates to a method for the manufacture of foam moulded parts. Further the present invention relates to foamed moulded parts. The present method comprises the following steps: i) providing polymer foam granules, ii) mixing the polymer foam granules with a glue composition, iii) addition of a heat transfer medium to the mixture obtained in step ii) in order to obtain a foamed moulded part.

Abstract: The present invention features processes of making tablets having reduced internal fractures. In one aspect, the processes comprise the steps of (1) compressing a pre-tabletting material in a die to form a tablet, where an internal surface of the die is lubricated with at least one lubricant, and the pre-tabletting material comprises at least one therapeutic agent and at least one pharmaceutically acceptable polymer; and (2) ejecting said tablet from said die. In another aspect, the processes employ a granular or powdery pre-tabletting material which comprises at least one therapeutic agent and at least one pharmaceutically acceptable polymer, wherein 90% of the particles in the pre-tabletting material are smaller than 400 ?m.

Abstract: A method of building a three dimensional (3D) structure includes micro-dispensing a layer comprising a material using a syringe-based micro-dispensing tool, curing the layer, and repeating the steps of micro-dispensing and curing a plurality of times in order to build the three-dimensional structure. The material may be loaded with nano to micron sized particles, tubes, or strings.

Abstract: The present invention relates to a pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, one or more surfactants with lubricant properties, one or more dry binders with disintegrant properties, one or more fillers and one or more disintegrants.

Abstract: The present invention concerns solid compressed oral pharmaceutical compositions comprising a mixture of at least two sulphate salts selected from the group consisting of sodium, potassium and magnesium for use, in particular, in cleansing the colon or treating faecal impaction, constipation, faecal retention, intestinal gas and cramping, or flatulence in a mammal. Methods of producing such compositions are also disclosed.

Abstract: An apparatus and method for producing defect-critical articles from a molding resin comprising at least 98% clear polymer and additives including a heat stabilizer and a UV blocker in an injection molding machine. According to the apparatus, there is provided an injection molding machine in combination with a molding resin. The injection molding machine's resin delivery assembly is made from a powder metallurgy formed into solid non-coated parts having a Chromium-Vanadium (Cr/V) blend. As the molding resin interacts with the resin delivery assembly, the resin only contacts the solid non-coated parts whereby the resin experiences less degradation and provides improved quality for the defect-critical articles. The method includes the steps of plasticizing, injecting, and cooling. During the plasticizing and injecting steps, the molding resin only contacts solid non-coated parts made from a powder metallurgy material containing a Chromium-Vanadium (Cr/V) blend thereby producing reduced defect articles.

Abstract: A lignocellulosic product comprises a plurality of lignocellulosic pieces, and an isocyanate component and a processing aid disposed on the pieces. The processing aid is reactive with the isocyanate component, comprises a graft polyol having a continuous and discontinuous phase, and can be used to form a lignocellulosic composite article. The processing aid is useful for imparting the composite article with moisture resistance, swelling resistance, and toughness, as well as providing cold-tack during manufacture of the composite article from the product. The continuous phase comprises an isocyanate-reactive component. The discontinuous phase comprises polymeric particles. The isocyanate component and the processing aid are present in the product a combined amount of from about (1) to about (25) parts by weight based on (100) parts by weight of the product.

Abstract: A method and an apparatus for gluing wood particles, in particular wood strands, is described, as well as a method for the manufacturing of lignocellulosic products, in particular chip boards, oriented strand boards or fiber boards. Since the wood particles are blended in a blending device with a water-curable binder, in particular with polymeric diphenylmethane diisocyanate and moisture is added to the wood particles outside the blending apparatus, curing of the binder inside the blending apparatus, and as a consequence pollution thereof, can be avoided. Moreover, moisturizing outside the blending device can produce a particular even distribution of moisture.

Abstract: This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.

Abstract: Method of manufacturing a three-dimensional object of a building material by an additive layer-wise building method, wherein based on material parameters of the building material and predetermined characteristics of the object to be manufactured, an internal structure of the object having a grid structure calculated, and the three-dimensional object is manufactured with this internal structure by the additive layer-wise building method, so that it comprises the predetermined characteristics.

Abstract: Fluffy powders, such as calcined kaolin clays or air floated clays, can be compacted using a process which comprises applying increasing amounts of pressure to a powder moving through a confinement area. The compacted product has an improved bulk density and improved wet out and slurry incorporation times as compared to the non-compacted starting material feed.

Abstract: A novel solid composition and methods for making and using the solid composition are provided. The solid composition comprises: (a) at least one active agent with a solubility of less than about 0.3 mg/ml in an aqueous solution with a pH of at most about 6.8 at a temperature of about 37° C.; and (b) a hydrophilic polymer matrix composition comprising: i) a hydrophilic polymer selected from the group consisting of METHOCEL™, POLYOX™ WSR 1105 and combinations thereof; and optionally ii) a hydrophobic polymer selected from the group consisting of Ethocel 20 premium; and (c) an alkalizer selected from the group consisting of calcium carbonate, magnesium oxide heavy and sodium bicarbonate; wherein the composition provides at least about 70% release of the active between about 7 to about 12 hours following oral administration.

Abstract: A method for making a smooth ceramic including loading ceramic powder to be densified into a hot press die, placing one or more spacers with a polished surface between a hot press punch and the ceramic powder, placing the die and punch into a hot press and hot pressing the ceramic powder, and removing a smooth ceramic shape that requires no subsequent polishing or processing and has a surface roughness of 5 nm RMS or better. The smooth ceramic shape may be transparent, and it may be spinel, magnesia, yttria, lutetia, scandia, YAG, any composites thereof, or any of their rare earth doped compounds. Also disclosed is the related smooth ceramic made by this process.

Abstract: A method of forming a component from solid freeform fabrication comprising the step of building an integral support around the component during manufacture thereof. The stiffness the support provides to the component is selected to minimize deformation of the component either during the manufacture of the component or during a subsequent heat treatment process.

Abstract: Method for producing a fibrous web exclusively from cellulose fibers of natural origin, comprising the following procedural steps: forming an essentially uniformly thick, dry fiber layer from loose fibers having a low moisture content, pressing and embossing the fiber layer to obtain a fibrous web and forming an embossed pattern, moistening the fibrous web with a water-latex mixture having a high water concentration (75 to 99% by weight of water) and precipitating the latex in a drying process while the fibers are bonded inside and outside the fiber bond zones.

Abstract: The present invention relates to a novel biocide composition for use in gravity fed water purification devices and suitable for purifying water for drinking purposes and a process for preparing the novel biocide composition. The biocide tablet composition comprises one or more halogenated 5, 5-dialkylhydantoin compound; a chlorine biocide compound selected from trichloroisocyanuric acid (TCCA) or sodium dichloroisocyanurate (NaDCC) or mixtures thereof; 0.1-1.0% water soluble boron containing compound; wherein the ratio between the halogenated 5, 5-dialkylhydantoin compound and chlorine biocide compound is in the range 85:15 to 65:35 and the average particle size of the halogenated 5, 5-dialkylhydantoin compound and chlorine biocide compound is in the range 400 to1200 microns.

Abstract: Bone cement compositions and methods of making two-part bone cements. The methods comprise transferring premixed powder and a liquid component into a receptacle, and mixing the powder component and the liquid component to form a cement composition. The premixed powder component comprises an acrylic polymer and a radical initiator. The bone cement is loaded with from about 5% to about 6% gentamicin by weight of the powder component, and from about 4% to about 5% vancomycin by weight of the powder component. The methods include filling a mold cavity with the bone cement composition to form a temporary spacer implant. The bone cement compositions provide a viscosity profile sufficient for the bone cement composition to flow within the mold cavity for an elapsed working time period of greater than about 6 minutes from the start of mixing at approximately 23° C.

Abstract: Disclosed is an aluminum nitride substrate for a circuit board, the substrate having aluminum nitride crystal grains with an average grain size of 2 to 5 ?m and a thermal conductivity of at least 170 W/m·K. The aluminum nitride substrate does not include a dendritic grain boundary phase and has a breakdown voltage of at least 30 kV/mm at 400° C. Also provided is a method for producing the aluminum nitride substrate, including the steps of heating a raw material containing an aluminum nitride powder to 1500° C. at a pressure of at most 150 Pa, then increasing and holding the temperature at 1700 to 1900° C. in a pressurized atmosphere of at least 0.4 MPa using a non-oxidizing gas, then cooling to 1600° C. at a cooling rate of at most 10° C./min.

Abstract: A system and associated aspects thereof are disclosed regarding custom-compounding of drug products such as pills and polypills for particular patients, herein involving adaptations of “micro-dosing” technology to permit sufficiently small and precise amounts of drug substances or optionally formulations thereof to be controllably and automatably handled and dispensed so as to help create customized drug products that do not necessitate bulking or dilution of the drug substances.

Abstract: The invention relates to an oral dosage form containing deferasirox, binder, disintegrant and optionally wicking agent, wherein the introduction of the dosage form into water leads to a suspension wherein the suspended particles have an average particle size (D50) of 20 ?m to 120 ?m, and also to a method of producing it.

Abstract: The present invention is related to a method for testing multilayer tablets in a multiple rotary press, in which die holes of a circulating die plate are successively filled with tablet material of different layers in succeeding filling devices, and the tablet material is compressed one layer after the foregoing layer into pressed articles having n layers by means of synchronously circulating compression punches, and the pressed articles are subsequently ejected in an unloading station and taken out, in which in a testing procedure, pressed articles with m layers are taken out after the compression in a respective unloading station and are conveyed to a testing station, wherein applies 1<=m<=n, wherein before taking out the pressed articles, at least the m-th layer is compressed more strongly than during the normal manufacture of the multilayer tablets, wherein applies m<n.

Abstract: A die set for forming explosive charge liners from powdered material is provided. The die set comprises a die block defining a basin and a punch shaped to interact with the basin. The die block and the punch are configured to exclude powdered material from a center axis of the basin.

Abstract: The present invention relates to a pharmaceutical composition comprising ciprofloxacin or salts of thereof and amoxycillin or salts of thereof and other pharmaceutical excipients. The present invention provides more reliable effect against all bacteria, including the most commonly causative streptococci, responsible for especially respiratory tract infections. The invention makes up for the weakness of ciprofloxacin against streptococci.

Abstract: A process for making a fibrous panel member. The process includes mixing a porous fiber material with a MDI adhesive. The fiber batt is compressed between a pair of porous belts. Steam and heat are applied to the compressed batt to form a bound flexible batting material.

Abstract: Described herein are compositions comprising (a) 92 to 99 weight percent, of polyoxymethylene with number average molecular weight from 65,000 to 250,000 g/mole; and (b) 1 to 8 weight percent of an imidized acrylic resin obtained by treating an acrylic polymer with a monoalkyl amine, wherein the weight percents of a and b are based on their combined weight, and monoalkyl group has from one to five carbon atoms, the degree of imidization is 20% to 100% and the acid level is from 0 to about 2 weight percent of the imidized acrylic resin. The composition has significantly higher heat deflection temperature than the neat polyoxymethylene. Processes of increasing heat deflection temperature of POM compositions are described herein by blending (a) and (b), wherein the resultant melt-mixed composition has a 200% increase or greater in time to 5% creep strain relative to the same melt-mixed composition lacking (b).