Abstract: A hollow carbon sphere having a carbon shell and an inner core is disclosed. The hollow carbon sphere has a total volume that is equal to a volume of the carbon shell plus an inner free volume within the carbon shell. The inner free volume is at least 25% of the total volume. In some instances, a nominal diameter of the hollow carbon sphere is between 10 and 180 nanometers.

Abstract: A nano-composite, including: a plurality of secondary particles, each secondary particle including a mixture of nano-size primary particles, wherein the mixture of nano-size primary particles includes particles including a nickel oxide or a copper oxide, and particles including zirconia doped with a trivalent metal element or ceria doped with a trivalent metal element, and wherein the nano-size primary particles define a plurality of nano-pores.

Abstract: The present invention relates to a process for producing nanoparticles comprising at least one polymer and/or copolymer by providing an aerosol comprising droplets of at least one monomer and at least one photoinitiator in a gas stream, irradiating this aerosol stream with light such that the monomers present polymerize, and removing the nanoparticles formed from the gas stream, to nanoparticles producible by this process and to the use of these inventive nanoparticles in optical, electronic, chemical or biotechnological systems, or for active ingredient administration.

Abstract: The present invention relates a metal passivator additive comprising: a rare earth component; alumina; clay; colloidal silica; and a zeolite having high silica to alumina ratio.

Abstract: Provided is a glucose sensor including a titanium dioxide-graphene composite having a porous structure. More particularly, the glucose sensor includes a working electrode having the titanium dioxide-graphene composite having the porous structure and an enzyme to provide features that allow a current flow to be excellent, a current to be sensitively changed depending on a change in electric potential, sensitivity to be high, and a low voltage characteristic to be excellent.

Abstract: A process for producing particles of a substance is described wherein a solution of the substance in a solvent is delivered in at least one shot into a supercritical fluid. The supercritical fluid is a non-solvent for the substance and is miscible with the solvent. Particles of the substance distributed in a mixture of the solvent and the supercritical fluid are formed.

Abstract: According to the invention, powders of low hygroscopicity are prepared by granulation of an aqueous solution (1) in a fluidized bed (140). A compound formed from crystalline grains whose moisture content is defined and stable is obtained. The invention applies especially to organometallic complexes of glycine with a metal.

Abstract: The present invention relates to a method for production of separation media using a so called Spinning Disc technology wherein the porosities of the beads are optimized in such a way that a desired biomolecule may be separated from a complex sample. The method comprises the following steps: a) feeding a 4-8% polysaccharide solution, which has a viscosity within 350-450 mPas, at 65-75° C. to one or more spinning discs at 3001-3010 rpm to form polysaccharide beads; b) capturing said formed polysaccharide beads in a capturing bath; wherein the porosity of the polysaccharide beads is controlled by varying the temperature of the capturing between 15 and 27° C., preferably between 17.5 and 24.6° C. The method yields porosities that prevent molecules larger than 150 000 g/mol to diffuse into the beads. The invention also relates to separation media produced by the method and use thereof for purification of biomolecules, in particular monoclonal antibodies.

Abstract: This disclosure relates to a method and a system of producing nanoparticles and nanoparticle matrices of thermolabile, biocompatible matrix materials, like lipids and biopolymers with controlled properties. A prototype pulse-heat aerosol system is described for single-step production of free, thermolabile nanoparticles with sufficient control over size, morphology and crystallinity with controlled-release properties, for possible therapeutic, cosmetic or diagnostic use. Nanoparticles of the range 50 to 500 nm are obtained and are found suitable for controlled drugs delivery.

Abstract: A method and formulation for preparing spray dried vancomycin. In various embodiment, the formulation includes vancomycin HCl (10-20%) and one or more of the following PEG (0-5%), mannitol (0-5%), ethanol (0-10%), and a citrate buffer. Spray dried vancomycin has favorable reconstitution times and water content.

Abstract: This disclosure relates to a method of preparing polyamide particles. The method include spray drying a solution containing a polyamide to form polyamide particles having an average diameter of between about 0.5 ?m and about 10 ?m and at least about 85% of the polyamide particles having a diameter distribution of no more than about 1.5 ?m.

Abstract: Dry liquids having a particle size distribution (cumulative undersize) D10% ?80 to 140 ?m D50% 140 to 200 ?m D90% 190 to 340 ?m are prepared by passing the liquids and a hydrophobic, pyrogenically prepared silica through a clearly defined, spatially limited shear zone in which the liquids are broken up into small droplets and are surrounded by the hydrophobic, pyrogenically prepared silica.

Abstract: Multicomponent nanoparticles materials and apparatuses and processes therefor are disclosed. In one aspect of the disclosure, separate particles generated from solution or suspension or by flame synthesis or flame spray pyrolysis, and the resultant particles are mixed in chamber prior to collection or deposition. In another aspect of the disclosure, nanoparticles are synthesized in stagnation or Bunsen flames and allowed to deposit by thermophoresis on a moving substrate. These techniques are scalable allowing mass production of multicomponent nanoparticles materials and films. The foregoing techniques can be used to prepare composites and component devices comprising one or more lithium based particles intimately mixed with carbon particles.

Abstract: A method for evenly preparing filament by using high-shearing solution of ultrahigh-molecular-weight polyethylene is disclosed. The method involves mixing an ultrahigh-molecular-weight polyethylene with a solvent in a predetermined ratio, and processing the mixture through a high-shear method to prepare an ultrahigh-molecular-weight polyethylene emulsion solution that is extruded by a dual-screw extruder and quenched in chilled water into a gel protofilament. The gel protofilament is then cleaned by a hydrocarbon cleaning agent before undergoing extraction drawing, drying and hot drawing multiple times so as to form high-tenacity, high-modulus polyethylene fiber. The resultant fiber has good mechanical properties and less fiber misalignment while its production enjoys advantages of low energy consumption, good production conditions, and short production cycle.

Abstract: Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability in a use environment.

Abstract: A particulate positive electrode material for lithium ion cells is prepared by dispersing manganese(II) sulfate, iron(II) sulfate, and lithium phosphate and/or lithium hydrogenphosphate in water to form a slurry, effecting hydrothermal reaction in an autoclave to synthesize a lithium compound: LiMnxFe1-xPO4 wherein x=0.05 to 0.5 as primary particles, preparing a dispersion comprising the primary particles and an organic substance, spraying the dispersion, granulating, and drying to form aggregated particles having an average particle size of 0.5-4 ?m, and firing the aggregated particles at 600-780° C. for carbonizing the organic substance therein, yielding secondary particles having a reduced carbon content.

Abstract: A lithium metal oxide positive electrode material useful in making lithium-ion batteries that is produced using spray pyrolysis. The material comprises a plurality of metal oxide secondary particles that comprise metal oxide primary particles, wherein the primary particles have a size that is in the range of about 1 nm to about 10 ?m, and the secondary particles have a size that is in the range of about 10 nm to about 100 ?m and are uniformly mesoporous.

Abstract: The present systems and methods utilize a polyamic acid solution as a precursor to form a polyimide bead having desired properties. The polyamic acid solution may be formed into a polyamic acid droplet. The polyamic acid droplet is then processed to form a polyamic acid bead, such as by extraction of solvent to concentrate the polyamic acid or by partial chemical imidization of the polyamic acid. The polyamic acid bead is then better able to retain its shape during subsequent processing steps, such as drying and pressurizing, before final thermal imidization.

Abstract: A method of producing equal-sized spherical shaped beads of a wide range of materials is described. These beads are produced by forming the parent bead material into a liquid solution and by filling equal volume cells in a sheet with the liquid solution. The sheet cells establish the volumes of each of the cell mixture volumes which are then ejected from the cells by an impinging fluid. Surface tension forces acting on the ejected equal sized solution entities form them into spherical beads. The ejected beads are then subjected to a solidification environment which solidifies the spherical beads. The beads can be solid or porous or hollow and can also have bead coatings of multiple material layers.

Abstract: A method for preparing uniquely sized nanoparticles of CaF2 by simultaneously spray drying a first NH4F and a biocompatible salt solution and a second Ca(OH)2 and biocompatible salt solution to form CaF2 solid particles in a soluble salt matrix wherein the salt is more soluble than CaF2. The salt matrix may then be dissolved and the separate CaF2 nanosized particles collected for use as a dental therapeutic material. The technique is useful in the preparation of other discrete, nanoparticle sized compounds and combinations by carefully choosing the solvents and solutes of the two spray dried solutions.

Abstract: This invention relates to a process for producing a spray-dried powder comprising microcrystalline cellulose in a solid dispersion of the anti-HIV compound etravirine (TMC125) in a water-soluble polymer.

Abstract: A process is proposed for the preparation of a powder comprising one or more complexing agent salts of the general formula starting from an aqueous solution comprising the one or more complexing agent salts in a concentration of from 10 to 80% by weight, based on the total weight of the aqueous solution, in a spray-drying process, comprising an atomization step and a drying step, wherein the atomization step is carried out with the addition of crystalline fine dust of the same complexing agent salt(s) as are present in the aqueous solution, or one or more complexing agent salts different therefrom, with an upper limit for the average particle diameter of the crystalline fine dust which is lower by at least a factor of 2 than the lower limit of the average particle diameter of the powder obtained after the process, in a fraction of from 0.1 to 20% by weight, based on the weight of the powder obtained after the process.

Abstract: The present invention relates to a spray-dried composition comprising as an active ingredient at least one member protein of the collectin family or its functional equivalent for treating and preventing microbial infectious diseases. The present invention also relates to a method for producing the same composition. The composition produced by the method of the present invention is effective in suppressing infections caused by viruses, bacteria, fungi, and parasites. Since the composition is developed in a form suitable for inhalation, it can directly provide the active ingredient to the sites of infection from these microbes, and thus treat and prevent respiratory infections and external wounds.

Abstract: The invention relates to a device and a method for producing nanoparticles, in which method starting materials for nanoparticles are mixed at least as liquid droplets and optionally also as gases and/or vapors with at least combustion gases in a premixing chamber and the mixture is separated for liquid drops larger than size d, whereafter the mixture is conducted to at least one burner, in which the combustion gases are ignited such that a heavily mixing flame is generated, in which the starting materials react and optional solvents evaporate and generate through nucleation and/or sintering and/or agglomeration particles having a diameter of 1 to 1000 micrometers.

Abstract: The invention relates to a process for preparing microspheres comprising an ionically crosslinked polymer, the process comprising: (a) producing liquid aerosol droplets (13) from a solution (3) comprising an ionically crosslinkable polyionic polymer into a continuous gas stream by using an ultrasonic nebulizer; (b) transferring the gas stream into a gelling solution (10) comprising di-, multi- or polyvalent ions, whereby crosslinked polymer microspheres (14) are formed, (c) separating the microspheres from the gelling solution, and (d) optionally, filtering the microspheres through a screen.

Abstract: A method and apparatus of forming compositionally homogeneous particles is provided. The method includes forming a homogenous melt from a plurality of constituent materials under a first pressure sufficient to prevent substantial vaporization of the constituent materials. Droplets are generated from the homogenous melt. The droplets are cooled under a second pressure sufficient to prevent substantial vaporization of the constituent materials at least until the homogeneous particles formed therefrom have stabilized.

Abstract: A granulator, having a granulation unit having a bottom floor with a perforated plate as its bottom part; an upper air-supplying pipe for supplying a fluidizing air to the bottom floor of the granulation unit; a lower air-supplying pipe; air-spouting pipes, each of which is branched from the lower air-supplying pipe, and has an opening in the bottom floor of the perforated plate, for jetting the air into the granulation unit; and spray nozzles for spraying a granulation raw material liquid, which each are provided in the center of an air outlet of the air-spouting pipe, or a granulator, having: the bottom floor; the air-supplying pipe; and spray nozzles for spraying a granulation raw material liquid each of which are provided in an opening in the bottom floor of the perforated plate, and use a high-pressure atomizing air as an auxiliary gas, wherein, in each granulator, the spray nozzles are provided in a triangular arrangement.

Abstract: The invention relates to manufacturing processes for preparing inhalable powders, and to the stable crystalline inhalable powders prepared by this process. Similarly, the invention relates to the use of these inhalable powders for preparing a medicament for the treatment of respiratory complaints, particularly for the treatment of COPD (chronic obstructive pulmonary disease) and asthma.

Abstract: A process for treating fly ash to render it highly usable as a concrete additive. A quantity of fly ash is obtained that contains carbon and which is considered unusable fly ash for concrete based upon foam index testing. The fly ash is mixed with a quantity of spray dryer ash (SDA) and water to initiate a geopolymerization reaction and form a geopolymerized fly ash. The geopolymerized fly ash is granulated. The geopolymerized fly ash is considered usable fly ash for concrete according to foam index testing. The geopolymerized fly ash may have a foam index less than 40%, and in some cases less than 20%, of the foam index of the untreated fly ash. An optional alkaline activator may be mixed with the fly ash and SDA to facilitate the geopolymerization reaction. The alkaline activator may contain an alkali metal hydroxide, carbonate, silicate, aluminate, or mixtures thereof.

Abstract: A process for treating fly ash to render it highly usable as a concrete additive. A quantity of fly ash is obtained that contains carbon and which is considered unusable fly ash for concrete based upon foam index testing. The fly ash is mixed with an activator solution sufficient to initiate a geopolymerization reaction and for a geopolymerized fly ash. The geopolymerized fly ash is granulated. The geopolymerized fly ash is considered usable fly ash for concrete according to foam index testing. The geopolymerized fly ash may have a foam index less than 35% of the foam index of the untreated fly ash, and in some cases less than 10% of the foam index of the untreated fly ash. The activator solution may contain an alkali metal hydroxide, carbonate, silicate, aluminate, or mixtures thereof.

Abstract: A process for producing polystyrene foam particles having a bulk density in the range from 40 to 400 g/l by extrusion of a polystyrene melt comprising carbon dioxide and/or water as blowing agent through a nozzle and underwater pelletization, wherein the underwater pelletization is carried out at a pressure in the range 1-30 bar.

Abstract: Provided is a method for pelleting spherical fine particle of sodium nitrate, which comprises the following steps: 1) melting industrial sodium nitrate in a salt melting furnace, introducing into a high-level insulation buffer tank, placing in an atomizer located on top of the pelleting tower, atomizing to obtain fog droplets with size of 30 ?m-0.5 mm; 2) introducing freeze-dried high-pressure air into the pelleting tower in a tangent direction from the upper inlet pipe of the tower, so that the sodium nitrate fog droplets obtained in step 1) fall spirally along the wall in the pelleting tower, to obtain sodium nitrate particle; 3) collecting the cooled sodium nitrate particle at the bottom of the tower, and packaging. Sodium nitrate particle with lower water content, higher roundness, and smaller size can be obtained, and continuous production can be realized by the method.

Abstract: Processes for producing a filter material which contains heatsealable, biodegradable and compostable polymeric fibers and is characterized in that it additionally contains a lubricant in an amount from 0.5 to 5.0% by weight, based on the paper weight of the ready-produced filter material.

Abstract: A method for manufacturing a fine polymer including: generating superheated steam by a superheated steam generating unit (101); adjusting the pressure of the generated superheated steam by a pressure adjusting unit (102); receiving a polymer by a reception unit (103); heating the received polymer to a predetermined temperature by a heating unit (104); discharging the heated polymer through a first discharge port (111); and discharging the superheated steam through a second discharge port (121) at the same time as the time when the heated polymer is discharged. Here, the second discharge port (121) surrounds the first discharge port (111), and the first discharge port (111) and the second discharge port (121) face the same direction.

Abstract: A method and apparatus are provided for atomizing a liquid under dispersal conditions suitable for spray drying at a commercial plant scale. In one embodiment, a liquid atomizer has a structural body adapted for connection with a spray dryer and a plurality of atomizing nozzles. Each of the atomizing nozzles includes a liquid nozzle adapted to disperse a supply of liquid and a gas nozzle adapted to disperse a supply of gas. In another embodiment, a process for producing a powder blend of at least two target substances in a single processing step is provided.

Abstract: The invention provides microparticles for use in a pharmaceutical composition for Pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolution of the active substance. The invention also provides a method for making the microparticles.

Abstract: The present invention provides a process for isolating tigecycline which process comprises the step of spray drying a solution of tigecycline in a solvent. Preferably the solvent is water or an organic solvent. In another aspect, there is provided tigecycline obtainable by spray drying, particularly in amorphous form. In particular, the invention provides tigecycline obtainable by spray drying according to the process of the invention.

Abstract: Methods and systems are provided for converting molten sulfur to powder sulfur by gas cooling of atomized sprays of molten sulfur. Certain embodiments contemplate a vertical tower that allows molten sulfur to produce an atomized spray or mist of molten sulfur descending from the top of the vertical tower. Gas introduced to the bottom of the vertical tower flows upward intimately interfacing with the descending atomized molten sulfur spray. The molten sulfur in the form of an atomized sulfur spray is cooled by the gas to form a sulfur powder. In certain embodiments, the sulfur powder formed is sufficiently small to be suitable for combination with a base fluid for producing a slurry for convenient transport of the sulfur particulates. Advantages of certain embodiments include higher efficiencies, lower cost, and production of much smaller solid sulfur average particulate sizes, which in turn allows for easier sulfur transport.

Abstract: Crystalline alumina particles are intimately mixed with a gaseous fuel, air and oxygen. The mixture is then ignited in a torch. Such blending of the powder with the combustible gas allows the alumina particles to be immediately heated to above their melting temperature and allows the particles to form into spheres. The spheres are then rapidly cooled to ambient temperature, providing high purity micron-sized polymorphic alumina spheres without the use of additives or special treatment.

Abstract: The process comprises delivering a spray solution comprising an active agent and a matrix material in an organic solvent to a spray-drying apparatus, atomizing the spray solution into droplets within the spray-drying apparatus to remove at least a portion of the organic solvent from the droplets to form a plurality of particles, and collecting the particles. The spray solution may be formed by forming a feed suspension comprising the active agent, the matrix material, and the organic solvent, wherein the feed suspension is at a temperature T1, and directing the feed suspension to a heat exchanger, thereby increasing the temperature of the feed suspension to a temperature T2, wherein T2 is greater than T1, and the spray solution is at a pressure greater than the vapor pressure of the organic solvent at T2, such that the active agent and matrix material are soluble in the organic solvent at T2.

Abstract: A method for producing a composite metal powder according to one embodiment of the invention may comprise: Providing a supply of molybdenum metal powder; providing a supply of a potassium compound; combining the molybdenum metal powder and the potassium compound with a liquid to form a slurry; feeding the slurry into a stream of hot gas; and recovering the composite metal powder.

Abstract: Spherical particles of one or more elemental metals and carbon are prepared from a precursor in the form of a metal oleate. The metal oleate precursor is dispersed in a liquid vehicle and aerosol droplets of the dispersed precursor are formed in a stream of an inert gas. The aerosol droplets are heated in the stream to decompose the oleate ligand portion of the precursor and form spherical particles that have a mesoporous nanocrystalline structure. The open mesopores of the spherical particles provide a high surface area for contact with fluids in many applications. For example, the mesopores can be infiltrated with a hydrogen absorbing material, such as magnesium hydride, in order to increase the hydrogen storage capacity of the particles.

Abstract: A particle generator is able to generate pure particles for solid or liquid materials with melting points over several hundred degrees Celsius. The material is heated to generate the vapor in a small chamber. Heated nitrogen or some inert gas is used as the carry gas to bring the mixture into a dilution system. As the super saturation ratio of the material is large enough and over a critical value, particles are formed in the dilution system by homogenous nucleation, and grown in the same dilution system as well. The different size distributions and concentrations of the particles can be obtained by varying dilution parameters, such as residence time and dilution ratio.

Abstract: Particulate chemical substances and method of manufacturing thereof wherein the resultant particles have a narrow particle size distribution and sufficient hardness to ensure that particles can withstand intact being driven through pneumatic transportation equipment. The method comprises granulating raw material using a spray granulation apparatus having a nozzle plate equipped with nozzle pipes having a length in the range of 2-100 mm.

Abstract: The invention is directed to making non-hollow, non-fragmented spherical metal or metal alloy particles.

Abstract: A supercritical fluid polymer depolymerization machine is disclosed herein, which machine is capable of converting a wide range of biomass and/or waste plastic materials into a plurality of reaction products (liquid and gaseous) including fermentable sugars, hydrocarbons, and various aromatic substances that, in turn, are readily convertible into liquid transportation fuel known as “neodiesel.

Abstract: Methods and apparatus for hydrodischarging and hydrocharging substrates and articles to produce enhanced ability to avoid attraction of contaminants or improved capability of removing contaminants from fluids are disclosed. In another form the method involves removal of electric charges or neutralization of charge on or within substrates. Also disclosed are methods of making using electret substrates and articles for removing particulates and mists from fluid streams.

Abstract: The present invention relates to a preparation method for a biodegradable polymer microparticle and a microparticle prepared by the method. More particularly, the present invention relates to a method for preparing a polymer microparticle, wherein the method includes the steps of: dissolving a biodegradable polyester-based polymer in DMSO (Dimethyl Sulfoxide); spraying the solution in a low temperature hydrocarbon solution to provide a frozen DMSO microparticle; adding the microparticle in a low temperature salt aqueous solution to dissolve DMSO; and removing salt. The present invention provides a method for preparing a novel polymer microsphere which can be injected through a syringe due to excellent physical properties (such as biocompatibility, biodegradability, porosity, mechanical strength) and the microcarrier's size-adjustability, and can be easily mass-produced.

Abstract: To provide a process for producing high-purity highly oxidized refractory particles easily with good productivity by treating a spent refractory containing ZrO2 and Al2O3 to reduce components other than ZrO2 and Al2O3 to levels unproblematic for practical use as raw material for electrofused refractories and to increase the content of the ZrO2 and/or Al2O3 component. A process for producing refractory particles, which comprises introducing to and melting in a melting furnace both a spent refractory which contains, by mass % as chemical components, from 75 to 97% of ZrO2 and/or Al2O3, from 2 to 25% of SiO2, from 0.4 to 7% in total of Na2O, K2O and Li2O(Na2O+K2O+Li2O), at most 2% of CaO and at most 2% of MgO, and carbon particles in an amount of from 1 to 8% by outer mass percentage based on the spent refractory, and after the melting, tapping the melt while blowing compressed air against the melt to form refractory particles having the content of ZrO2 and/or Al2O3 increased.

Abstract: The present invention concerns a process for producing a granulate based on lactose and cellulose (derivative), a granulate obtainable by the process and its use as a tabletting excipient.