Abstract: The present invention relates to pharmaceutical compositions of Eliglustat. In particular the present invention relates to stable amorphous Eliglustat premix having enhanced stability and dissolution properties. The present invention also provide a stable premix composition comprising amorphous Eliglustat or a pharmaceutical acceptable salt thereof, pharmaceutical compositions comprising the premixes, and processes for preparing the same. The compositions prepared in the present invention includes sublingual or mouth dissolving tablets, and capsules of Eliglustat and/or its pharmaceutically acceptable salts thereof and at least one pharmaceutically acceptable carrier.

Abstract: A temperature-controlled shield for an evaporation source is described. The temperature-controlled shield is configured to provide a pre-heating zone or a post-cooling zone.

Abstract: The present invention provides a process for preparing a carbon nanotube sheet, which comprises forming carbon nanotubes; aggregating the carbon nanotubes to form a yarn; treating the yarn with a solvent to enhance the aggregation force; winding the solvent-treated yarn to prepare a sheet preform having a structure in which one yarn is continuously wound; and cutting and/or pressing the sheet preform to prepare a carbon nanotube sheet that comprises an arrangement structure in which one or a plurality of yarns are uniaxially aligned, and a carbon nanotube sheet prepared thereby.

Abstract: A cell freeze-drying system, comprising: a temperature-elevated nitrogen supplier, a freeze-drying operation box, and a gas discharger, which are connected in that order using a first connection pipe. The temperature-elevated nitrogen supplier supplies warmed nitrogen to the freeze-drying operation box. A cell sample frozen by liquid nitrogen is placed in the freeze-drying operation box, and then the freeze-drying operation box, which is preset to a temperature suitable for placing the cell sample frozen by liquid nitrogen, is warmed up in a preset mode while continuously being supplied with the warmed nitrogen to sublimate solid state water in the cell sample into gaseous water. The gas discharger is used to discharge the gaseous nitrogen and the gaseous water. Further disclosed is a cell freeze-drying method. The invention can effectively address an issue of cell damage and contamination during freeze-drying, and realizes safety, efficiency, and low costs for cell freeze-drying.

Abstract: The invention relates to a solid, particulate, urea-based composition comprising urea in particulate form and a urease inhibitor of the type phosphoric triamide, in particular N-(n-butyl) thiophosphoric triamide (nBTPT), wherein the urea-based composition is further characterized in that it comprises one or more alkaline or alkaline-forming inorganic compounds. The composition according to the invention has been stabilized against the degradation of a urease inhibitor of the type phosphoric triamide, in particular N-(n-butyl) thiophosphoric triamide (nBTPT) in the presence of urea. The invention further relates to a method for the manufacture of the claimed solid, particulate, urea-based composition.

Abstract: A method for producing a micron-size spherical silica aerogel having a selectable or controllable average particle size, the method includes producing a surface-modified silica sol by adding a first organosilane compound to a aqueous acid-silica sol, which comprises an inorganic acid and a water glass solution, with a pH less than 3, dispersive mixing a non-polar organic solvent, a second organosilane compound, and the surface-modified silica sol, at a selected stilling rate which is inversely related to an average particle size, without adding any surfactant or dispersant, a micron-size spherical silica hydrogel and further a hydrophobic micron-size spherical silica gel are then produced. Following by drying or stirring the hydrophobic micron-size spherical silica gel to obtain a controllable micron-size silica aerogel in a spherical and powder forms, respectively.

Abstract: The invention relates to nanoparticles for the systemic or topical delivery of lipophilic diagnostic or therapeutic agents to a subject in need thereof. The nanoparticles of the invention comprise a water soluble polymer and at least one of a biocompatible lipid and a lipophilic agent. The invention further relates to ophthalmic treatment using the nanoparticles of the invention. In addition, the invention pertains to compositions and formulations comprising the nanoparticle of the invention. Such formulation may be an eye drop formulation.

Abstract: The present disclosure provides a silica aerogel-including blanket including a substrate for a blanket; and a silica aerogel and an opacifying agent locating at least one of on a surface of and inside the substrate for a blanket, wherein the opacifying agent is a second particulate with inorganic particles of a first particulate being aggregated, and includes 1 to 5 of the inorganic particles per unit volume of 1 ?m3, and a method for preparing the same. The silica aerogel-including blanket according to the present disclosure is capable of exhibiting flame retardancy as well as an excellent insulation property, particularly, an excellent insulation property at high temperatures, by including an opacifying agent having excellent dispersibility and high surface activity through chemical etching.

Abstract: A method for manufacturing adhesive resin pellets includes adding an antiblocking agent to water, melting an adhesive resin and extruding the adhesive resin into the water, and cutting the adhesive resin extruded into the water to form adhesive resin pellets. Polyolefin fine particles used for the antiblocking agent have an average particle diameter of 1 ?m or more and less than 18 ?m, and the adhesive resin has an adhesive force of less than 15.00 N/25 mm.

Abstract: Methods of sterilizing microparticles using a porous solid matrix which allows penetration of a sterilizing gas such as EtO to pass through are disclosed. The methods also include preparing a suspension of the sterilized microparticles by reconstituting the porous matrix containing the microparticles.

Abstract: Embodiments of the present disclosure provide for methods of making quantum dots (QDs) (passivated or unpassivated) using a continuous flow process, systems for making QDs using a continuous flow process, and the like. In one or more embodiments, the QDs produced using embodiments of the present disclosure can be used in solar photovoltaic cells, bio-imaging, IR emitters, or LEDs.

Abstract: An ethylene-vinyl alcohol copolymer composition can be formed into a product having very few minute fisheyes. The ethylene-vinyl alcohol copolymer composition comprises: an ethylene-vinyl alcohol copolymer; and an iron compound; wherein the ethylene-vinyl alcohol copolymer is a saponification product of an ethylene-vinyl ester copolymer prepared by using an organic compound having a half-life of 10 to 300 minutes at 60° C. as a polymerization initiator; wherein an amount of the iron compound is 0.001 to 2 ppm in terms of a metal by weight of the ethylene-vinyl alcohol copolymer composition.

Abstract: The invention relates to nanoparticles for the systemic or topical delivery of lipophilic diagnostic or therapeutic agents to a subject in need thereof. The nanoparticles of the invention comprise a water soluble polymer and at least one of a biocompatible lipid and a lipophilic agent. The invention further relates to ophthalmic treatment using the nanoparticles of the invention. In addition, the invention pertains to compositions and formulations comprising the nanoparticle of the invention. Such formulation may be an eye drop formulation.

Abstract: The present disclosure provides a silica aerogel-including blanket including a substrate for a blanket; and a silica aerogel and an opacifying agent locating at least one of on a surface of and inside the substrate for a blanket, wherein the opacifying agent is a second particulate with inorganic particles of a first particulate being aggregated, and includes 1 to 5 of the inorganic particles per unit volume of 1 ?m3, and a method for preparing the same. The silica aerogel-including blanket according to the present disclosure is capable of exhibiting flame retardancy as well as an excellent insulation property, particularly, an excellent insulation property at high temperatures, by including an opacifying agent having excellent dispersibility and high surface activity through chemical etching.

Abstract: The invention relates to aqueous suspension pharmaceutical compositions of poorly water soluble drugs, wherein said drugs are selected from compounds of formula I wherein R1-R9 are defined herein; processes for preparing these compositions and their use in medicine, especially their use in the treatment of ocular diseases.

Abstract: A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.

Abstract: A method for producing silica aerogel according to the present invention includes: a solation step of generating a sol by adding monoalkyltrialkoxysilane to an acidic aqueous solution containing silicic acid; and a gelation step of generating a wet gel by gelating the sol. Moreover, the production method includes a drying step of removing a solvent, which is contained in the wet gel, from the wet gel by drying the wet gel at less than a critical temperature of the solvent and at less than a critical pressure of the solvent. Then, the monoalkyltrialkoxysilane is added to the acidic aqueous solution so that an amount of silicon in the monoalkyltrialkoxysilane becomes 1 mol part or more with respect to 1 mol part of an amount of silicon in the acidic aqueous solution containing the silicic acid.

Abstract: Provided is a method for continuously manufacturing carbon nanotube fibers with high strength and high conductivity, which includes synthesizing carbon nanotube fibers by direct spinning; treating the carbon nanotube fibers with a strong acid while applying tension thereto; and washing the carbon nanotube fibers treated with the strong acid.

Abstract: The present invention suggests a power control apparatus and method of a vehicle which switch the switching frequency component generated in the power supply module to odd-number times of a Nyquist frequency which is the most ignorable in the frequency domain which is used for the FMCW radar, thereby preventing the erroneous detection due to the switching frequency in the FMCW. The present invention provides a power control apparatus of a vehicle radar, including: a first frequency signal generating unit which generates a first frequency signal with a predetermined amplitude; a second frequency signal obtaining unit which converts a frequency value of the first frequency signal to obtain a second frequency signal; and a power supply control unit which controls the power to operate a vehicle radar based on the second frequency signal.

Abstract: The molecular weight of a semi-crystalline starting polyester comprising ethylene 2,5-furandicarboxylate units is enhanced by heating the semi-crystalline starting polyester, having a melting point Tm, at a temperature in the range of (Tm-40° C.) to Tm to obtain a solid stated polyester, where the semi-crystalline starting polyester has an intrinsic viscosity of at least 0.45 dL/g, and an amount of carboxylic acid end groups in the range of 15 to 122 meq/kg.

Abstract: Disclosed is a novel method of making a structuring agent for edible dispersions such as margarines or spreads. Fat, or another structuring component, is subjected to a process involving mixing it with liquefied gas or supercritical gas, and expanding the mixture through an orifice. In the invention, water is added to the mixture prior to expansion, so as to provide a spray liquid in the form of a fat and water emulsion.

Abstract: The invention relates to aqueous suspension pharmaceutical compositions of poorly water soluble drugs, wherein said drugs are selected from compounds of formula (I) (Formula (I)), wherein R1-R9 are defined herein; processes for preparing these compositions and their use in medicine, especially their use in the treatment of ocular diseases.

Abstract: The present invention relates to a method for producing microcapsules having a calibrated diameter and at least one parameter characteristic of the mechanical properties of an equally calibrated microcapsule, characterized in that the method includes the steps of: producing microcapsules by means of injection into a microsystem (10) of three fluids (f1, f2, f3); deforming the microcapsules by means generating a flow within a capillary tube (20); observing and acquiring the outline of at least one deformed microcapsule observed by an optical acquisition means (30); comparing the acquired outline with outlines from a collection of reference microcapsule outlines; determining the diameter and said at least one parameter characteristic of the mechanical properties of the observed microcapsule; and modifying the flow rates (Q1, Q2, and/or Q3) of the fluids (f1, f2, f3). The present invention also relates to a system for producing calibrated microcapsules.

Abstract: A core-shell particle formulation for delivering multiple therapeutic agents is disclosed. More particularly, the formulation comprising protein-protein core-shell particle configured to independently release therapeutic agents from the core and the shell. Moreover, the core-shell particle bearing therapeutic agents enable treatment against the diseases such as cancer, inflammatory and auto-immune diseases.

Abstract: Example embodiments are directed to methods of producing desired isotopes in commercial nuclear reactors using instrumentation tubes conventionally found in nuclear reactor vessels to expose irradiation targets to neutron flux found in the operating nuclear reactor. Example embodiments include assemblies for retention and producing radioisotopes in nuclear reactors and instrumentation tubes thereof. Example embodiments include one or more retention assemblies that contain one or more irradiation targets and are useable with example delivery systems that permit delivery of irradiation targets. Example embodiments may be sized, shaped, fabricated, and otherwise configured to successfully move through example delivery systems and conventional instrumentation tubes while containing irradiation targets and desired isotopes produced therefrom.

Abstract: The present disclosure provides tissue fillers. The tissue fillers can include a plurality of tissue particles formed from acellular tissue matrix fragments. The tissue fillers can be used to fill tissue sites, such as voids formed after tissue resection. The disclosure also includes methods of treating tissue using the tissue fillers. The tissue particles can each be formed of tissue fragments having certain sizes.

Abstract: The invention generally relates to a bi-directional reactor and supported amine sorbent, and more particularly to a method and system for carbon dioxide sequestration utilizing a bi-directional reactor and monoethenalamine (MEA) on a substrate. The bi-directional reactor is configured to reclaim the sorbent material as the sorbent is immobilized during the sorption phase, but is mobilized during desorption phased. The immobilized sorbent reacts with the desired contaminate to absorb and is transported to another reactor during desorption phase, thereby permitting reclamation of the sorbent.

Abstract: A resin pellet of the present invention includes a resin base material and a plurality of microparticles embedded in the resin base material. The resin pellet is covered with the plurality of microparticles on the surface of the resin base material. According to the present invention, it is possible to prevent detachment of the microparticles to be applied on the resin base material and to effectively suppress blocking of resin pellets.

Abstract: Apparatuses and processes for forming powder are disclosed. The apparatus includes a chamber having a head plate and an array of aerosol and burner nozzles attached to the head plate for generating aerosols and flames respectively. Powder is produced by atomizing a liquid composition to project an aerosol of droplets into the chamber and heating the aerosol with flames projected by the burner nozzles.

Abstract: Disclosed are a thermoelectric material and a method of forming a thermoelectric material having an optimal stoichiometry, the method including obtaining a first precursor material, wherein the first precursor material is an antimony precursor, and obtaining a second precursor material, wherein the second precursor is chosen from the group consisting of a tellurium precursor and a selenium precursor. The method further includes combining the precursor materials, heating the combination of precursor materials, and isolating a plurality of semiconductor nanocrystals from the heated precursor materials.

Abstract: The present invention relates to the use of a liposomal preparation for the manufacture of a pharmaceutical composition and the use of such a composition for the treatment of “triple receptor negative” breast cancer.

Abstract: A method for producing starch granules suitable as an excipient for an orally disintegrating tablet. Fluidized bed granulation is performed by spraying a starch paste in small amounts while a ?-starch is being fluidized using an air-fluidized bed. Subsequently, fluidized bed drying is performed at a temperature equal to or higher than the gelatinization temperature of the ?-starch. This yields starch granules having a high degree of gelatinization in comparison with the amount of ?-starch adhered to the ?-starch by the spraying of the starch paste. These starch granules alone impart satisfactory oral disintegratability and breaking strength to the tablet. Accordingly, when used as an excipient during tableting of orally disintegrating tablets, other auxiliary excipients such as saccharides or crystalline cellulose need not be added.

Abstract: Use of two different methods, either each by itself or in combination, to enhance the stiffness, strength, maximum possible use temperature, and environmental resistance of thermoset polymer particles is disclosed. One method is the application of post-polymerization process steps (and especially heat treatment) to advance the curing reaction and to thus obtain a more densely crosslinked polymer network. The other method is the incorporation of nanofillers, resulting in a heterogeneous “nanocomposite” morphology. Nanofiller incorporation and post-polymerization heat treatment can also be combined to obtain the benefits of both methods simultaneously. The present invention relates to the development of thermoset nanocomposite particles.

Abstract: This disclosure relates to a method of preparing polyamide particles. The method include spray drying a solution containing a polyamide to form polyamide particles having an average diameter of between about 0.5 ?m and about 10 ?m and at least about 85% of the polyamide particles having a diameter distribution of no more than about 1.5 ?m.

Abstract: A method and formulation for preparing spray dried vancomycin. In various embodiment, the formulation includes vancomycin HCl (10-20%) and one or more of the following PEG (0-5%), mannitol (0-5%), ethanol (0-10%), and a citrate buffer. Spray dried vancomycin has favorable reconstitution times and water content.

Abstract: One of the purposes of the present invention is to provide an aqueous dispersion of silicone elastomer particles to provide a stable emulsion and the silicone elastomer particle, wherein a polyoxyethylene alkyl ether which has an alkyl group having a large number of carbon atoms is used as a surfactant. Further, another purpose is to provide a cosmetic comprising said aqueous dispersion or said silicone elastomer particles and giving a good feeling in the use. The present invention provides an aqueous dispersion comprising (A) silicone elastomer particles having a 90% volume cumulative diameter (D90) of 0.3 to 20 ?m in an amount of 5 to 80 mass %, based on a total mass of the aqueous dispersion, (B) at least one polyoxyethylene alkyl ether having an alkyl group having 18 carbon atoms in an amount of 0.01 to 15 mass %, based on a total mass of the aqueous dispersion, wherein a hydrophile-lipophile balance (HLB) of the polyoxyethylene alkyl ether is 12.8 to 15.

Abstract: A system for making PET objects including a means for reacting a first PET precursor and a second PET precursor to produce a PET melt; a means for flowing the PET melt to a valve having at least two outlets; a means for flowing the PET melt from at least one of the at least two outlets to at least one distribution manifold, each of the at least one distribution manifold having at least two distribution lines; a means for controlling individually the mass flow of the PET melt in each of the at least two distribution lines independently of the other of the at least two distribution lines; and a means for forming the PET objects from the PET melt.

Abstract: A method for producing metal-supported carbon includes supporting metal microparticles on the surface of carbon black, by a liquid-phase reduction method, in a thin film fluid formed between processing surfaces arranged to be opposite to each other so as to be able to approach to and separate from each other, at least one of which rotates relative to the other.

Abstract: The present invention features an orally disintegrating dosage form including from about 5% to about 40%, by weight, of at least one hydrated salt and a pharmaceutically active agent, wherein the at least one hydrated salt has a dehydration temperature of from about 20 to about 120 ° C.

Abstract: A mixture of fine powder including thorium oxide was converted to granulated powder by forming a first-green-body and heat treating the first-green-body at a high temperature to strengthen the first-green-body followed by granulation by crushing or milling the heat-treated first-green-body. The granulated powder was achieved by screening through a combination of sieves to achieve the desired granule size distribution. The granulated powder relies on the thermal bonding to maintain its shape and structure. The granulated powder contains no organic binder and can be stored in a radioactive or other extreme environment. The granulated powder was pressed and sintered to form a dense compact with a higher density and more uniform pore size distribution.

Abstract: Provided herein relates to methods and compositions for preparing a silk microsphere and the resulting silk microsphere. In some embodiments, the methods and compositions described herein are all aqueous, which can be used for encapsulating an active agent in a silk microsphere, while maintaining activity of the active agent during processing. In some embodiments, the resulting silk microsphere can be used for sustained delivery of an active agent encapsulated therein.

Abstract: The present invention provides for methods of preparing silk nanoparticles and microparticles, methods of encapsulating an active agent into the silk nano- and microparticles and compositions comprising these silk particles. In particular, the silk spheres are prepared from phase separation of silk and polyvinyl alcohol (PVA), without exposure to an organic solvent. The method employs a chemical, PVA, which is an FDA-approved ingredient in drug formulations. Different parameters can be adjusted to control the size and shape of the silk spheres during the fabrication process. The silk particle compositions of the present invention may also encapsulate active agents or chemicals. Such compositions allow the active agents to be controllably and sustainably released to the target organs or tissues. The silk composition entrapping active agents also provides for a long-term storage medium for the active agents so entrapped.

Abstract: The invention relates to a process for the preparation of a nicotinamide powder, comprising the steps of providing an aqueous solution of nicotinamide and spray drying the solution. The invention also relates to a nicotinamide powder, devices for its production and uses.

Abstract: The present invention relates to sustained release formulations comprising as active ingredient octreotide or a pharmaceutically-acceptable salt thereof and two or more different polylactide-co-glycolide polymers (PLGAs).

Abstract: The present disclosure is directed at a pharmaceutically active nanoparticle suspension that may be optically clear. Such suspensions may be formed by selective dissolution of a pharmaceutically active compound in a first solvent followed by introduction into a second solvent, such as an aqueous medium, without substantial use of surfactants and/or mechanical shear.

Abstract: The present invention provides a method of producing a carbon material for lithium ion secondary battery negative electrode, the carbon material containing a plurality of carbon particles, the method comprising the steps of: preparing a resin dispersion material containing a dispersion medium and a plurality of resin particles which are substantially insoluble in the dispersion medium; ejecting a plurality of liquid droplets of the resin dispersion material using a liquid droplet ejecting method, the liquid droplets each containing the dispersion medium and at least one of the resin particles; and heat-treating the plurality of liquid droplets so that the resin particle contained in each liquid droplet is carbonized while removing the dispersion medium to thereby obtain at least one of the carbon particles from each liquid droplet.

Abstract: A method of preparing a positive active material for a lithium secondary battery represented by the following Chemical Formula 1 (LiwNixCoyMn1-x-y-zMzO2) includes: (a) preparing a metal salt aqueous solution including a lithium raw material, a manganese raw material, a nickel raw material, and a cobalt raw material; (b) wet-pulverizing the metal salt aqueous solution using beads having a particle diameter of 0.05 to 0.30 mm at 2000 to 6000 rpm for 2 to 12 hours to prepare a slurry; (c) adding a carbon source to the slurry; (d) spray-drying the slurry of the step (c) to prepare a mixed powder; and (e) heat-treating the mixed powder.

Abstract: The present invention relates to the field of methods for providing components of pharmaceutical compositions comprising poorly water-soluble drugs. In particular the present invention relates to methods for providing stable, amorphous hybrid nanoparticles, comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component, useful in pharmaceutical compositions.

Abstract: The invention relates generally to a process for the preparation of water-absorbent polymer particles, comprising the process steps including of drying the polymer gel particles wherein in process step (viii) the gel particles obtained in process step (vii) are charged onto the surface of the belt material of a belt dryer at a position L0 and are subsequently dried on their way through the belt dryer and wherein the belt material has been cooled before coming into contact with the gel particles. The invention also relates to water-absorbent polymer particles obtainable by such a process.

Abstract: Provided is a polycarbonate resin composition pellet, which has a light transmittance at a wavelength of 380 nm of 97.0% or more when the light transmittance is measured by using a methylene chloride solution having a concentration of 12 g/dL, the solution being charged into a quartz glass cell having an optical path length of 5 cm, and which has a viscosity-average molecular weight (Mv) of from 11,000 to 22,000.