Abstract: The present disclosure envisages a process for pelletizing carbon black by mixing carbon black powder and water in a proportion in the range of 0.1:2 to 2:1 with a binding agent and a dispersing agent. The dispersing agent is an amine-based surfactant and is added in a proportion in the range of 0.005-0.1% of the total mixture. The mixture is pelletized in a pelletizer and subsequently the raw pellets are dried for 20-60 minutes at a temperature between 150-250° C., to obtain the carbon black pellets. The process of the present disclosure provides uniform distribution of water on the surface of the pellets giving a uniform pellet quality, reduced water consumption, energy savings and an increased production rate.

Abstract: Disclosed herein are methods of treating diseases and disorders responsive to inhibition of Hsp90, pharmaceutical compositions, pharmaceutical dosage forms and medicaments useful for the treatment of diseases responsive to inhibition of Hsp90, and methods of making the pharmaceutical compositions, pharmaceutical dosage forms and medicaments.

Abstract: A device for the production of a three-dimensional object made of solidifiable material having at least one processing unit (11) for the processing of the solidifiable material into a liquid phase to discharge the material from a material reservoir (12) via a discharge unit (13) in the direction of a construction space (17) in the form of intermittent drops (15). The conditions required for this can be satisfied (FIG. 2) via the closing mechanism featuring a plastic malleable solid body joint (24).

Abstract: A wound healing device includes a mat of aligned nanofibers of polyaniline, o-aminobenzenesulfonic acid copolymer, polyvinyl alcohol and chitsosan oligossacaride. Method for fabricating the mat and treating wounds are also disclosed.

Abstract: A ceramic material has the following composition: (Ba1-xMnx)O.z(Ti1-yMmy)O2.Dd.Ee. In this composition, (Ba1-xMnx)=A and (Ti1-yMmy)=B, where Mn stands for at least one element selected from: Mg, Ca, Sr, Pb and mixtures thereof; Mm stands for at least one element selected from: Sn, Zr and mixtures thereof; D stands for at least one element having donor properties; E stands for at least one element having acceptor properties. The following applies for the parameters: 0?x?0.6; 0?y?0.35; 0?d?0.02; 0?e?0.02; 1<z; and the following applies for the molar ratio of B to A: 1<B/A. The ceramic material comprises Si only as an impurity.

Abstract: A novel polycrystalline stoichiometric fine SiC fiber substantially free of impurities is produced using a novel pre-ceramic polymer. The pre-ceramic polymer is prepared by reacting a mixture of chlorodisilane, boron trichloride, and a vinyl chlorodisilane with an excess of hexamethyldisilazane to form the pre-ceramic polymer resin, which may then be melt-spun, cured, pyrolyzed and heat-treated to obtain the finished SiC fiber. The manufacturing process for the production of the fine SiC ceramic fiber allows for flexibility with respect to cross-linking, in that low-cost thermal treatments may replace more complex methods, while obtaining fibers with improved materials properties as compared to currently available SiC fibers.

Abstract: In order to avoid compromising the pharmacological effect of pancreatin caused by the addition of auxiliary materials or binding agents, a pancreatin pellet having a 100% pancreatin content consists exclusively of pancreatin with a residual moisture content of less than 3% by weight, preferably less than 1% by weight or less than 0.5% by weight.

Abstract: A fine agglomerates mixture formed from pyrolysis of recyclable polymeric material such as scrap tires, polymeric automotive components, used rubber materials, and plastic containers. The mixture contains a carbon content ranged between about 80% to about 95% by weight of the fine agglomerates mixture. The fine agglomerates mixture has agglomerate particles averaging less than or equal to 35 nm. The fine agglomerates mixture also has a nitrogen surface area greater than or equal to 73 m2/g and includes an inorganic functional filler in a range between about 5% to about 20% weight of the fine agglomerates mixture.

Abstract: Systems for pelletizing hot asphaltenes are provided. Asphaltenic hydrocarbons can be dispersed to provide two or more asphaltenic particles. The asphaltenic hydrocarbons can be at a temperature of from about 175° C. to about 430° C. The asphaltenic particles can be contacted with a film of cooling medium. The film can have a thickness of from about 1 mm to about 500 mm. At least a portion of the asphaltenic particles can be solidified by transferring heat from the asphaltenic particles to the cooling medium to provide solid asphaltenic particles. The solid asphaltenic particles can be separated from at least a portion of the cooling medium.

Abstract: A porous and permeable composite for treatment of contaminated fluids, said composite including a body of iron particles and 0.01-10% by weight of at least one functional ingredient distributed and locked in the pores and cavities of the iron body. Also, methods of making a permeable porous composite for water treatment. Also, use of a permeable porous composite for reducing the content of contaminants in a fluid, wherein said fluid is allowed to pass through the permeable composite.

Abstract: The invention relates to novel solid formulations comprising as pharmaceutically active compound pimobendan and to processes for producing such solid formulations. The invention furthermore relates to a method for manufacturing a medicament for the prevention and/or treatment of congestive heart failure, wherein the solid formulations according to the invention are used.

Abstract: Sulfur (or sulphur) spray nozzles disposed with a cooling tank spray liquid molten sulfur into the cooling liquid in the tank. Solid sulfur seeds are formed in the cooling liquid and settle in the tank. The cooling tank may be a spiral dewaterer tank that has a screw conveyor at the bottom of the tank that moves the seeds to a granulating drum for enlargement into sulfur granules. The cooling tank may also be used to capture and remove sulfur dust from a slurry of sulfur dust and water recycled from the granulating drum. The sulfur dust in the cooling tank may be captured by contact with molten sulfur droplets streaming down the cooling liquid column such that the dust particles become incorporated into the droplet, thereby being converted to seed. The granulating drum may be equipped with two or more sets of segmented lifting flights. The sets of flights may not be in alignment. The flights may be spaced apart from the inside surface of the drum with segmented rib members.

Abstract: An oral delivery product comprising a semi-permeable pouch designed for delivery of an active agent in the oral cavity of a subject. The pouch encloses multiple particles, and the particles are alginate matrices that comprise an active agent, e.g. nicotine. The alginate is e.g. sodium alginate, such as Protanal LFR 5/60 or Protanal LF 10/60.

Abstract: The present invention relates to a new iron containing phosphate adsorbent and its use e.g. for treating hyperphosphataemia.

Abstract: The present invention has as an objective to provide protein particles which have strongly reduced surface activity, and can be used as an ingredient in foams and aerated food products while not interfering with stabilisers at the gas bubble interface. This invention provides a method to produce such aggregated protein particles, as well as the aggregated protein particles which have strongly reduced surface activity.

Abstract: The present invention relates to formulations comprising atazanavir and a silicate, and the process of preparation thereof, wherein the silicate is present in the extragranular portion.

Abstract: A method for forming nanofiber web comprises the steps of: mixing (21) polymeric material with a solvent to obtain a liquid mixture having a viscosity above a predetermined shear viscosity value at room temperature; feeding (23) a spray nozzle with said mixture; projecting (25) said mixture through said nozzle with a gas jet, wherein the projected polymeric material solidifies and forms nanofibers; depositing (27) said nanofibers on a collecting surface to form said nanofiber web.

Abstract: Granule comprising lipid powder particles having a microporous structure.

Abstract: The invention relates to a method for test pressing tablets with at least two layers.

Abstract: The present invention relates to pharmaceutical compositions of DPP IV inhibitors with an amino group, their preparation and their use to treat diabetes mellitus.

Abstract: This invention relates to non-woven fabrics, in particular to a method of making fabrics by spraying fibres onto a support member, and to a mixture of fibres, binder and diluent for use in the method of the invention. The present invention has the objective of providing a composition that can be used to produce fabrics having an improved texture and which gives excellent results when sprayed as an aerosol using a propellant.

Abstract: Compartmentalized chips of at least two chemically similar crystallizable thermoplastic polymers each having a different intrinsic viscosity placed in separate zones are disclosed. These compartmentalized chips exhibit thermal characteristics that are different from the traditional technique of homogeneously combining the two materials into the chip. These compartmentalized chips in their amorphous, crystalline and solid phase polymerized forms exhibit a longer crystallization half time than the homogeneous mixture, thus permitting faster injection cycle times when compared to an equivalent homogenous mixture.

Abstract: The present invention relates to a composite of carbon nanotubes and of graphenes in agglomerated solid form comprising: a) carbon nanotubes, the content of which represents from 0.1% to 50% by weight, preferably from 10% to 40% by weight relative to the total weight of the composite; b) graphenes, the content of which represents from 0.1% to 20% by weight, preferably from 1% to 10% by weight relative to the total weight of the composite; and c) a polymer composition comprising at least one thermoplastic polymer and/or one elastomer. The present invention also relates to a process for preparing said composite, its use for the manufacture of a composite product, and also to the various applications of the composite product.

Abstract: The invention relates to a composite ceramic material which comprises: (a) a first phase based on zirconia containing CeO2 as stabilizer, and (b) a second phase based on an aluminate. The invention also relates to a ceramic powder composition, processes for the preparation of the composite ceramic material and the ceramic powder composition as well as uses thereof.

Abstract: A high-efficacy, long-acting, slow-release formulation of the poorly soluble drug, comprising solid dispersion of the poorly soluble drug, silica nanoparticles loaded with the poorly soluble drug, matrix material, and release enhancer, wherein the mass ratio of these components is solid dispersion of the poorly soluble drug: silica nanoparticles loaded with the poorly soluble drug: matrix material: release enhancer=1: 0.5˜1.25: 0.1˜0.3: 0.1˜0.3; the said solid dispersion of the poorly soluble drug contains povidone K30, soybean lecithin, and acrylic resin IV, wherein the mass ratio of the drug and the accessory materials is poorly soluble drug: povidone K30: soybean lecithin: acrylic resin IV=1: 1-3: 0.3˜0.8: 0.2˜0.5. Compared with the existing formulations, the in vivo half life of the high-efficacy, long-acting formulation of the poorly soluble drug disclosed in this invention is 2.3˜14.8 times longer while the mean residence time (MRT) of which is 7.94˜4.

Abstract: The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof, which exhibits high dissolution rates of amlodipine and losartan even under a low pH condition and improved storage stability.

Abstract: This invention relates to an improved method for making composite structures by dispersing a high tenacity fiber such as aramid in a polymeric matrix to form a premix, combining the premix with a natural fiber such as wood flour and extruding the resulting mixture through a fiber alignment plate and die such that the fibers are substantially aligned in the flow direction of the extrudate.

Abstract: A high-efficacy, long-acting formulation of silymarin, comprising silymarin solid dispersion, silymarin-loaded silica nanoparticles, slow-release matrix material and release enhancer, wherein the mass ratio of these components is silymarin solid dispersion:silymarin-loaded silica nanoparticles:slow-release matrix material:release enhancer=1:0.5˜1.25:0.1˜0.3:0.1˜0.3; the drug loading rate of the said silymarin-loaded silica nanoparticles is 51.95%-52.87%; the said silymarin solid dispersion contains povidone K30, soybean lecithin and acrylic resin IV, and the mass ratio between silymarin and other medical accessories in silymarin solid dispersion is silymarin:povidone K30:soybean lecithin:acrylic resin IV=1:1˜3:0.3˜0.8:0.2˜0.5. Compared with the existing formulations, the half life of the high-efficacy, long-acting formulation of silymarin disclosed in this invention is 2.3 times longer while the mean residence time (MRT) of which is 9.

Abstract: The embodiments herein provide a dental and medical biomaterial and its use for sealing and/or filling the tooth and bone cavities. In the embodiments herein, the calcium salt, calcium oxide, calcium silicate, and calcium phosphate compounds are mixed with a water-base solution, and a bioactive phosphate and calcium enriched mixture is prepared. The mixture comprises high concentration of water-soluble calcium and phosphate, and consequently forms hydroxyapatite during and after setting. The dental/medical biomaterial is biocompatible, antibacterial and capable of forming an effective seal against reentrance of microorganisms into the filled cavity. The biomaterial is compatible to handle and set in an aqueous environment and to stimulate soft/hard tissue healing/generation/regeneration.

Abstract: The present invention relates to a process for manufacturing an agglomerate in the form of beads made up of microcapsules of a phase change material, the process comprising wet-granulation and fluidized-bed drying.

Abstract: Systems and methods for pelletizing hot asphaltenes are provided. Asphaltenic hydrocarbons can be dispersed to provide two or more asphaltenic particles. The asphaltenic hydrocarbons can be at a temperature of from about 175° C. to about 430° C. The asphaltenic particles can be contacted with a film of cooling medium. The film can have a thickness of from about 1 mm to about 500 mm. At least a portion of the asphaltenic particles can be solidified by transferring heat from the asphaltenic particles to the cooling medium to provide solid asphaltenic particles. The solid asphaltenic particles can be separated from at least a portion of the cooling medium.

Abstract: A portable apparatus for producing sulphur granules includes a granulator with a rotatable drum having distinct zones for seed generation and product growth. The seed generation zone has an intense water spray pattern for each sulphur spray nozzle with intersecting water sprays to solidify molten sulphur and create seeds. The growth zone has a moderate, non-intersecting water spray pattern to allow sulphur nozzles to coat and grow a curtain of seeds into granules. The granulator's exhaust air is filtered either by a heated cyclone separator to recapture residual sulphur particles and moisture before venting, and/or by a granular air filter which uses the produced granules to filter the granulator's exhaust air. A two piece collar enhances maintenance of the granulator's drive system.

Abstract: A method for manufacturing an elastic deformation body made of an Al2O3 ceramic, according to which a highly pure alumina having at most 2000 ppm MgO, at most 200 ppm inorganic impurities, a specific surface of at least 10 m2/g, an average grain size of at most 0.3 ?m is applied. With the alumina and additives, there is produced via aqueous processing a homogeneous mixture, from which a pressable spray granulate is produced, which is formed by means of a uniaxial pressing method to a homogeneous, green body, which is subjected to a sinter process. The resulting elastic deformation body has a bending fracture stress ?c, whose distribution F(?c) is given by the Weibull parameters ?0?800 MPa and m?24, with an average grain size of the sintered material of no more than 2 ?m, and wherein the sintered material of the deformation body has a density of not less than 3.98 g/cm3.

Abstract: A sustained release composition comprising spray dried particles of at least one polysaccharide gum and at least one polyhydric sugar alcohol, as well as methods of making the sustained released composition are provided. A sustained release pharmaceutical solid dosage form, and a method of making the solid dosage form by compression are also provided.

Abstract: A process of making micro-sized protein particles comprising the step of drying nano-sized protein particles suspended in a liquid medium under conditions to agglomerate the nano-sized protein particles and thereby form micro-sized protein particles.

Abstract: A spinning apparatus comprising one or more exits for extruding liquid, and an exit for ejecting gas, located upstream of the exits for extruding liquid, wherein the apparatus comprises a columnar hollow for liquid, in which the exit for extruding liquid forms one end of the columnar hollow; the apparatus comprises a columnar hollow for gas having the exit for ejecting gas; a virtual column for liquid, extended from the columnar hollow for liquid, is adjacent to a virtual column for gas, extended from the columnar hollow for gas; the central axis of the columnar hollow for liquid is parallel to the central axis of the columnar hollow for gas; and there exists only one straight line having the shortest distance between an outer boundary of the cross-section of the columnar hollow for gas and an outer boundary of the cross-section of the columnar hollow for liquid, is disclosed.

Abstract: The present invention is directed to new methods for combining, processing, and modifying existing materials, resulting in novel products with enhanced mechanical, electrical and electronic properties. The present invention provides for polymer/carbon nanotube composites with increased strength and toughness; beneficial for lighter and/or stronger structural components for terrestrial and aerospace applications, electrically and thermally conductive polymer composites, and electrostatic dissipative materials. Such composites rely on a molecular interpenetration between entangled single-wall carbon nanotubes (SWNTs) and cross-linked polymers to a degree not possible with previous processes.

Abstract: The invention relates to a method for the production of carrier pellets for pharmaceutical active substances. Likewise, the invention relates to such carrier pellets and also to pharmaceutical formulations containing these. The carrier pellets according to the invention are used for transporting and releasing pharmaceutical active substances, in particular in the human body.

Abstract: The present application discloses a sustained release composition in pellet form, wherein the core of the pellet comprises: (a) a therapeutically effective amount of a medicament; (b) 0.5 to 50% by weight of a water-soluble polymer; and (c) 25% by weight of a water-insoluble polymer applied as an aqueous latex dispersion and subsequently the water is removed, wherein the sum of the percentages of the medicament, the water-insoluble polymer and the water-soluble polymer is equal to or less than 100%. It also discloses methods of making this composition.

Abstract: Process for preparing a powder comprising the steps of providing at least one first component in liquid form at ambient temperature, providing at least one second component having a melting point or melting range in the range from above ambient temperature to below the degradation temperature of said first component, forming a homogenous liquid mixture comprising the at least one first component and the at least one second component by stirring and heating the mixture to or keeping the mixture at a temperature in the range from above the melting point or melting range of the second component and below the degradation temperature of the first component, transferring the liquid mixture to at least one spray congealing unit, spray congealing the mixture, and isolating the powder obtained upon spray congealing.

Abstract: A method of producing nanoparticles comprises effecting conversion of a nanoparticle precursor composition to the material of the nanoparticles. The precursor composition comprises a first precursor species containing a first ion to be incorporated into the growing nanoparticles and a separate second precursor species containing a second ion to be incorporated into the growing nanoparticles. The conversion is effected in the presence of a molecular cluster compound under conditions permitting seeding and growth of the nanoparticles.

Abstract: A compound oxide manufacturing method includes: dispersing micelles, in each of which an aqueous phase is formed, in an oil phase; producing primary particles of a precursor of compound oxide in the aqueous phases in the micelles; synthesizing secondary particles by causing the primary particles to aggregate; and causing the secondary particles to aggregate by breaking the dispersion state of the micelles, or by causing the micelles to coalesce. In particular, polarization is produced in each of the micelles with the use of a cation having an ionic radius larger than that of a metal ion at least when the secondary particles are synthesized in the micelles.

Abstract: A polyaryletherketone polymeric material, for example polyetheretherketone and composite materials comprising said polymeric material are described. The polymeric material has a melt viscosity (MV) in the range 0.05 to 0.12 kNsm?2 preferably in the range 0.085 to 0.095 kNsm?2.

Abstract: The invention relates to a process for preparation of polymer blends comprising at least one polyoxymethylene and at least one thermoplastic elastomer, where the thermoplastic elastomer is micropelletized by a pelletizing process and the pellets obtained in a) are dispersed in the polyoxymethylene matrix via melting of the components and mixing of these at low shear forces, and also to the use of micropelletized thermoplastic elastomers for preparation of polyoxymethylenes with low formaldehyde emission.

Abstract: Methods and devices relating to polymer blend/bioceramic composite implantable medical devices are disclosed.

Abstract: The present invention provides a method of producing porous structures, particles or matrixes, which may be comprised of one or a plurality of components, an apparatus for carrying out the method and particles formed in accordance with the method. The method is particularly suitable for producing porous composite or pure particles for pharmaceutical applications. In accordance with the method, a composite comprising a material such as a pharmaceutical, a biodegradable polymers and/or a biological agent is formed. The composite must further comprise a material that is soluble in supercritical fluid. Extraction of the supercritical fluid soluble material produces porous structures, which may be in the form of particles or matrixes.

Abstract: The present invention relates to pharmaceutical compositions comprising at least one active ingredient delivered by a nanoparticle. More specifically, the invention relates to solid pharmaceutical compositions comprising nanoparticles, wherein the nanoparticles are in the form of agglomerates with elevated equivalent aerodynamic diameters. The invention further relates to a process for producing such nanoparticles.

Abstract: A process for manufacturing solid oral dosage forms in an equipment train that comprises multiple pieces of apparatus designed for unit operations, such as blending, extruding, cooling, milling and finishing. The equipment in the equipment train allow for the transfer of raw materials and intermediate-processed materials from one apparatus to the next using transfer means, for example, gravity, vacuum, belts, and the like.

Abstract: It is an object of the present invention to provide a fine particle granulation method capable of granulating fine particles in an extremely easy operation without the need for carrier particles that cannot be reliably isolated and removed or binders that remain as impurities, and of improving the handling properties of these fine particles, and of obtaining fine particles that can be rapidly broken down into primary particles during use. To achieve this object, the fine particle granulation method comprises an agitation step in which fine particles are dispersed in a supercritical fluid, and a spraying step in which the supercritical fluid with the fine particles dispersed therein is subjected to rapid adiabatic expansion.

Abstract: A process for manufacturing fiberboard by preparing a fiber slurry mixture including containing cellulose fibers and water then atomizing a liquid bituminous material, such as asphalt. The liquid bituminous material is atomized by mixing it with a pressurized gas, such as compressed air, forming a mist comprising droplets of bituminous material having a diameter between 20 microns and 50 microns. A water spray solidifies the bituminous material droplets thereby forming bituminous particles which fall into the fiber slurry within the spray chamber. From there the slurry is sheared, dewatered, and dried, forming a finished fiberboard.