Abstract: A hydraulic actuator system including an actuator and a valve assembly configured for bi-directional regeneration. The actuator may include a hollow body and a rod disposed within and extending outwardly from the hollow body. The rod may include a first chamber within the rod and a piston disposed at one end of the rod, defining a second chamber and a third chamber within the hollow body. A valve assembly may be in fluid communication with a first conduit, a second conduit, the first chamber, the second chamber, and the third chamber, wherein the valve assembly is configured to selectively couple one of the first conduit and the second conduit to one or more of the first port, the second port, and the third port, wherein one of the first conduit and the second conduit is configured as a pressure source.

Abstract: A system for recovering energy while treating a body of wastewater comprises a tank, a plurality of diffusers, a propeller, and a generator. The tank contains the body of wastewater. The plurality of diffusers is immersed in the body of wastewater and is operative to create motion therein by the discharge of bubbles. The propeller is immersed in the body of wastewater and is operative to spin in response to the motion in the body of wastewater. The generator is linked to the propeller and is operative to generate electrical energy in response to the spinning of the propeller.

Abstract: A vibrating meter (5) is provided. The vibrating meter (5) includes one or more conduits (103A, 103B) including a vibrating portion (471) and a non-vibrating portion (472) and a driver (104) coupled to a conduit of the one or more conduits (103A, 103B) and configured to vibrate the vibrating portion (471) of the conduit at one or more drive frequencies. The vibrating meter (5) also includes one or more pick-offs (105, 105?) coupled to a conduit of the one or more conduits (103A, 103B) and configured to detect a motion of the conduit. One or more meter components exclusive of the vibrating portion (471) of the conduits (103A, 103B), the driver (104), and the pick-offs (105, 105?) is provided with a damping material (310) applied to at least a portion of a surface of a meter component of the one or more meter components that reduces one or more vibrational resonant frequencies of the meter component below the one or more drive frequencies.

Abstract: The invention relates to a system for use in the treatment of produced water, e.g., water treatment in connection with hydrocarbon production operations. Silica in produced water produces undesirable scaling in processing equipment, which causes excess energy usage and maintenance problems. Electrocoagulation (EC) at relatively high water temperature, followed by any of membrane distillation (MD) or forward osmosis (FO), may be combined with a process of ceramic ultra-filtration (UF filtration) to treat water. Water to be treated may be produced water that has been pumped from a subterranean reservoir. The treated water may be employed to generate steam. The system comprises a plurality of units (e.g., EC, forward osmosis, membrane distillation unit, UF filtration, etc) which can be configured as an on-site installation or a mobile unit for on-site or off-site water treatment.

Abstract: A device forming a manometer, configured to measure pressure of a biphasic fluid in a fluidic network, including: a first channel inside which a biphasic fluid is able to flow; a second channel emerging into the first channel, wherein the second channel is blind, with each of its dimensions less than capillary length of the fluid's liquid phase, and with at least one of its lengthways wall having a surface energy gradient that decreases from its inlet to the end. The surface energy gradient enables the wetting angle of the meniscus of the fluid's liquid phase to be increased in the blind channel from its inlet to the end. Such a device may find application to measurement of pressure of a biphasic fluid in a heat exchanger or in a fuel cell.

Abstract: A pneumatic single-lumen medical gas conserver combines the advantages of typical single-lumen and dual-lumen conservers. In particular, a pneumatic single-lumen conserver can provide a rapid response to patient inhalations without the need for a more expensive dual-lumen cannula hose. In addition, after delivering oxygen the conserver has a specific pneumatically-implemented delay period before being able to detect the next inhalation to inhibit “double pulse” deliveries. In addition to a conserving or pulse flow mode, the conserver can provide a user-selectable gas flow at a continuous or constant flow mode.

Abstract: Embodiments of oxygen concentrators having a sieve bed that includes a vessel filled with a separation medium are disclosed. The sieve bed vessel at least partially supports one chassis component of the oxygen concentrator with respect to another chassis component. of the oxygen concentrator.

Abstract: A method of manufacturing a flow path member includes inserting the first flow path member into each concave portion of the second flow path member and welding the first flow path member and the second flow path member in a circumferential direction of a region where the first flow path and the second flow path communicates each other; and providing two or more injecting portions which are provided with a gap wider than a gap between a wall surface of the concave portion which faces the first flow path member and a circumference surface of the first flow path member inserted into each concave portion which faces the wall surface, communicate with each concave portion, and are opened to the same side as the concave portion to have a concave shape to each concave portion in the second flow path member.

Abstract: A spray nozzle assembly and hub combination for operation in a boiler feedwater deaerator is disclosed, the combination including a tubular hub capable of being affixed to a wall of a deaerator tank and a spray nozzle assembly that is removably engageable with the hub, the nozzle assembly including a nozzle body, a twist lock for retaining the nozzle body relative to the hub when the nozzle body is in a fully engaged position, and a spreader moveably coupled to the nozzle body and biased by a spreader spring against opening, the spreader is capable of moving to an open position against the spreader spring bias in response to boiler feedwater pressure to form an annular opening about the spreader, thereby enabling feedwater flow.

Abstract: A dispensing apparatus to dispense at least one of a first substance and a second substance therefrom includes a head having a first inlet to receive the first substance therethrough, a second inlet to receive the second substance therethrough, and an outlet to expel a mixture of the first substance and the second substance therefrom, with the head configured to vary a ratio of the mixture between substantially all of the first substance and substantially all of the second substance. The dispensing apparatus further includes a first airless chamber to contain the first substance therein, with the first airless chamber fluidly coupled to the first inlet of the head.

Abstract: The present invention provides a steam injection mechanism improved so that water accumulation on an object to be processed can be reliably restricted. A steam injection mechanism comprises a common channel through which steam supplied from a steam supply source flows and distribution channels branched from the common channel to distribute the steam from the common channel wherein the steam is injected from steam injection orifices formed in distal ends of the distribution channels to an object (a fibrous nonwoven fabric) to be processed. When the steam injection mechanism is located above the fibrous nonwoven fabric, the lowermost region of the common channel functions as a condensed water collecting region and, when the steam injection mechanism is located under the fibrous nonwoven fabric, the uppermost region of the common channel functions as the condensed water collecting region.

Abstract: A bidet system comprising an adaptor assembly, handle assembly, and attachment assembly. The adaptor assembly is adapted to be connected to a water system or other suitable liquid supply, and delivers liquid to the bidet system. The handle assembly allows a user to manipulate the flow and pressure of liquid to a discharge nozzle of the handle system. The attachment assembly is adapted to fix the handle assembly to a toilet.

Abstract: A microchannel chip is provided that is easily mountable irrespective of limitation of arrangement of devices therearound and relatively inexpensive in manufacturing cost. The microchannel chip includes: a substrate holder including a recess; a reaction substrate mounted in the recess of the substrate holder; a first sheet disposed so as to cover the substrate holder and the reaction substrate; and a second sheet disposed so as to cover the first sheet. The reaction substrate includes: a first surface exposed to the reaction chamber; and a second surface exposed to the outside through an observation window provided on the recess of the substrate holder. A reaction spot including a microstructure is formed on the first surface of the reaction substrate. The reaction spot is exposed to the reaction chamber.

Abstract: A piston assembly includes an outer shell, an end plate and an attachment column. A first flowed-material joint is disposed between and fixedly attaches the end plate and the outer shell to one another such that a fluid-tight seal is formed therebetween. A second flowed-material joint is disposed between and fixedly attaches the attachment column and the end plate to one another such that a fluid-tight seal is formed therebetween. A gas spring assembly and method that include the piston assembly are also included.

Abstract: A vehicle brake hydraulic pressure control unit includes a base body 1 incorporating therein a brake fluid flow path 1a and an electromagnetic valve 2 which is an assembled part assembled into a mounting hole portion 10A which is formed in the base body 1 in such a manner as to communicate with the flow path 1a. A hole wall of the mounting hole portion 10A has a plastically deformed portion 18 formed by pressing the hole wall in a downward direction of the mounting hole portion 10A. A locking groove 214 for the plastically deformed portion 18 to enter is formed on an outer circumferential surface of the electromagnetic valve 2. An outside diameter of the electromagnetic valve 2 at an upper side of the locking groove 214 is made smaller than an outside diameter of the electromagnetic valve 2 at a lower side of the locking groove 214.

Abstract: A drainage catheter including a body, a drainage lumen extending between the body proximal end and the body distal end, the drainage lumen including a distal fluid inflow port and a proximal fluid drain coupling, and an inflation lumen extending between the body proximal end and the body distal end, conveying inflating fluid from a proximal fluid supply element to a distal fluid acceptor balloon, the proximal fluid supply element adjacent the proximal fluid drain coupling. A sleeve may be secured about the proximal fluid supply element and the proximal fluid drain coupling to provide a fluid impervious coating.

Abstract: A fuel injector is described having a multi-orifice nozzle provided with a multitude of spray orifices through which fuel is injected, the multi-orifice nozzle having at least two spray orifices that have different spray-orifice diameters. Furthermore, a method is described for producing, by laser drilling, a multi-orifice nozzle having a multitude of spray orifices, at least two spray orifices having different spray orifice diameters.

Abstract: A cartridge for dispensing a stock liquid is provided. The cartridge includes a hollow body and a pump. A liquid dispenser suitable for numerous applications, having a removably insertable cartridge and methods of dispensing a liquid are also provided. Appliances including a removably insertable cartridge and methods of dispensing a liquid are also provided.

Abstract: The invention relates to a fuel injector for a fuel injection system, in particular a common rail injection system, having a nozzle body (1) and having an injector body (2), wherein in the nozzle body (1) there is formed a high-pressure bore (3) for accommodating a nozzle needle (4) which can perform a stroke movement and by means of the stroke movement of which at least one injection opening (5) can be opened up or closed off, and wherein in the injector body (2) there is formed a low-pressure chamber (6) for accommodating a piezoelectric actuator (7), which low-pressure chamber can be or is hydraulically coupled via a coupling device (8) to the nozzle needle (4) in such a way that the nozzle needle (3) assumes the closed position thereof when the piezoelectric actuator (7) is electrically discharged.

Abstract: Series of bio-detection elements, shown as short hollow transparent reaction vessels (32), batch-surface-coated with capture-agent, are placed in channel of larger width (a3; c8; 15; 28; 44), and fixed by flexible or elastomeric over-lying sheet (a1; c7; 13; 38). Portions of sheet form pneumatically-activated pistons (22; 36) and valves (23-27; 54) to produce and control channel flow. Overlying sheet is of reflectively-coated Mylar (b4) or PDMS, bonded with channel-defining structure. PDMS sheet is surface-activated for molecular-bond with PDMS channel-defining structure, molecular-bond with PDMS-valve-seat-forming portions (34) defeated by repeated make-and-break contact during cure. Pick-and-place of detection elements in channel employs electrostatic attraction to seize elements, enabling tool removal. Rigidly-backed parts are brought together to channel-fix detection elements. Active capture-agent on batch-coated bio-elements defeated by shear-force removal or laser-scanning deactivation, so, e.g.

Abstract: A method of installing a seal on a fuel injector includes installing a seal in a groove in an outer surface of the fuel injector. The seal is then clamped in a heated clamp portion at a temperature sufficient to soften a material of the seal to allow the material to flow into the seal groove. The seal is then cooled while being maintained in the clamped state to allow the heated material to set to a desired outer diameter size. The seal groove in the fuel injector may be provided with an extrusion zone into which the softened material of the seal is allowed to flow as the seal outer diameter is reduced to the desired diameter during the heating and clamping process.

Abstract: A flowmeter for detecting fluid flow rates in a pipe includes a tube having a channel disposed in the pipe through which fluid in the pipe flows. The flowmeter includes an upstream transducer in contact with the pipe and positioned so plane waves generated by the upstream transducer propagates through the channel. The flowmeter includes a downstream transducer in contact with the pipe and positioned so plane waves generated by the downstream transducer propagate through the channel and are received by the upstream transducer which produces an upstream transducer signal. The downstream transducer receives the plane waves from the upstream transducer and provides a downstream transducer signal. The flowmeter includes a controller in communication with the upstream and downstream transducers which calculate fluid flow rate from the upstream transducer signal and the downstream transducer signal. A method for detecting fluid flow rates in a pipe.

Abstract: A drop-in nozzle system for use with a multi-well or multi-column synthesizer or other element distribution system. The drop-in nozzle system includes one or more insertable/removable and/or disposable nozzle inserts, a nozzle housing, an input tube and a fitting. The one or more nozzle inserts are able to vary in length and have ferrule assembly positioned at the top of the insert. As a result, the system enables a user to disconnect a fitting from a nozzle housing cavity thereby releasing the system's liquid-tight seal, replace the current nozzle insert with another insert, and then reconnect the fitting recreating the liquid-tight seal and enabling the system for operation with the new nozzle insert.

Abstract: The present invention concerns a nozzle with a nozzle body on the back of which a blind hole or seat hole is realized, whereby at least one spray hole leads outward from the blind hole or seat hole, in such a way that the spray hole displays a non-round cross section in the area of the spray hole aperture.

Abstract: In a module system for manufacturing variants of two and three stable positions fluid-operated actuators a cylinder housing of both variants of two and three stable positions actuators is manufactured from a blank. The blank includes at least one opening for a cover and is identical for the variants of the two and three stable position actuator, and is at least prepared for the arrangement of a first pressure duct, a second pressure duct, and a first cylinder diameter of the cylinder housing.

Abstract: A microfluidic probe head includes a first layer, a second layer, and a first tubing port extending from an upper face of the first layer. The first layer has a first via, enabling fluid communication between the first port and a lower face of the first layer. The second layer includes a first aperture on a face, and a first microchannel enabling fluid communication between an upper face of the second layer, facing the lower face of the first layer, and the first aperture. The head enables fluid communication between the first via and the first microchannel. At least a portion of the first microchannel is a groove open on the upper face of the second layer, closed by a portion of a lower face of a layer of the head. The probe head further comprises a second tubing port, a second via, a second aperture and a second microchannel.

Abstract: An misting apparatus disperses odor-removing mist and comprises a reservoir assembly, misting pack(s), and a fan assembly. The reservoir assembly includes a reservoir and a baffle assembly. A reservoir receives and contains a deodorizing solution. The reservoir comprises an air flow inlet and a mist flow outlet. The baffle assembly is received in the reservoir and forms first and second chambers therewithin. The baffle assembly comprises air flow apertures for enabling air to flow from the first to the second chambers. The packs generate mist within the second chamber. The fan assembly generates air flow at the air flow inlet through the first chamber into the second chamber via the air flow apertures. The air flow into the second chamber thereby forms a mist flow which mist flow is directed through the mist flow outlet into the air surrounding the reservoir assembly for removing odors therefrom.

Abstract: Provided is a microfluidic control apparatus that includes at least one control means and a microfluidic control chip. When the microfluidic control chip is loaded to the control means, a needle provided to the control means is inserted into a reaction solution storage chamber of the microfluidic control chip, in which the reaction solution storage chamber is sealed with a sealing tape. Thus, fluid connection is easily formed between the microfluidic control chip and the control means without leakage.

Abstract: A configurable actuation-orientation valve (100) includes a valve body (120) including a valve bore (126) and a coil (180), a first port (101) and a third port (103) located at a first end (111) and a second port (102) located at a second end (112), a pole piece (138), an armature (130) configured to move in response to energization of the coil (180), and a biasing device (135) between the pole piece (138) and the armature (130). When the biasing device (135) is selected to provide a normally-closed biasing force to the armature (130) then the configurable actuation-orientation valve (100) comprises a normally-closed (NC) valve and when the biasing device (135) is selected to provide a normally-open biasing force to the armature (130) then the configurable actuation-orientation valve (100) comprises a normally-open (NO) valve.

Abstract: A system and method for launching promotional material is described. A gas-powered cannon having an actuation system and a magazine attached to the actuation system is provided. The magazine includes a plurality of tubes capable of receiving the promotional items to be launched. A promotional item is loaded into each tube, wherein loading includes loading a first promotional item in a first one of the plurality of tubes and loading a second promotional item into a different one of the plurality of tubes. The first promotional item is launched and then the magazine is rotated around the actuation system under gas power to line up the second promotional item. The second promotional item is then launched.

Abstract: A collar for a dispensing connector and a fitment assembly are disclosed. The connector collar engages a valved fitment for a container for holding and dispensing fluid. The fitment includes a spout connected to the container and a sliding internal valve body and an external valve body securely positioned within the spout. The connector collar has a fitment end mateable with the fitment so as to compress the top edge of the external valve body so as to form a seal between the external valve body and the dispensing connector.

Abstract: A device for blood-plasma separation and plasma-based blood analysis is described. The device uses blood samples smaller than 5 ?L, (directly from the finger) and flow is achieved with a degassing-driven flow technique that causes blood to flow spontaneously into air-filled dead-end channels without external pumping mechanisms.

Abstract: A dispensing device for a preferably cosmetic liquid as well as a method for the manufacture thereof are proposed. A lasting and tight joining of two materials is achieved while allowing for simple manufacture by pretreating the surface of the first material by means of plasma treatment or irradiation in a desired joining area in order to form radicals there or to break up the polymer chains of the first material, and by then injecting the second material directly against the first material. Another aspect consists in covering the first material with a second material for joining with another material or component.

Abstract: A cartridge (100) for containing and dispensing a medicament, the cartridge (100) including a cartridge body (104) having an interior cavity (10B) therein, a stopper (112) movably disposed within the interior cavity (108), and a septum (116, 148) disposed at an opposite end of the interior cavity (108) from the stopper (112), for containing the medicament within the Interior cavity (108). The cartridge (100) also Includes a connection thread (120) integrally formed as a unitary construction of the cartridge body (104), the thread (120) being disposed at a first end of the cartridge body (104) for connecting a pen needle directly to the cartridge body (104) to pierce the septum (116, 148) and provide communication between the medicament and a patient end of the pen needle.

Abstract: A portable system for subatmospheric pressure therapy in connection with healing a surgical wound includes a wound dressing dimensioned for positioning relative to a wound bed and a collection canister in fluid communication with the wound dressing. The canister includes a first vacuum chamber for drawing a vacuum and a second fluid chamber for collecting fluids removed from the wound dressing under the vacuum. The canister further includes a hydrophobic membrane separating the first and second chambers. The hydrophobic membrane is dimensioned to span a major portion of the cross-sectional area of the canister. The hydrophobic membrane may be dimensioned to substantially span an internal dimension of the collection canister. The hydrophobic membrane may include one or more outwardly extending lobes. The hydrophobic membrane may be releasably mountable to the canister, and, may be supported within a divider separating the first vacuum chamber and the second fluid chamber.

Abstract: A fuel rail includes an elongated tube having an inlet and a plurality of outlets. The elongated tube defines a fuel passageway for directing fuel toward the plurality of outlets. The fuel rail also includes a plurality of baffles positioned within the elongated tube to divide the fuel passageway into a plurality of chambers such that each outlet is positioned in one of the plurality of chambers. The plurality of baffles restricts fluid flow between adjacent chambers. A majority of the plurality of outlets are located essentially at an acoustic node of each corresponding chamber to reduce noise generated by the fuel rail.

Abstract: A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

Abstract: A fluid handling structure configured to supply immersion liquid to a space defined between a projection system and a facing surface facing the fluid handling structure, wherein the fluid handling structure has a main body with an undersurface, a moveable member moveable relative to the main body, and a self-regulating mechanism to maintain a gap of a certain size between a bottom surface of the moveable member and the facing surface independent of the size of a gap between the undersurface and the facing surface.

Abstract: Prosthetic valve devices for implantation in body vessels are provided. The prosthetic valve device includes at least one flexible member that permits fluid flow in a first direction and substantially prevents fluid flow in a second. The valve device also includes an inflatable chamber at least partially attached to the flexible member. The inflatable chamber is adapted to receive inflating media and is adapted to contact the body vessel. A delivery system is also provided that includes a valve device and a delivery apparatus. The delivery apparatus includes a member adapted for filling the chamber of the valve device with inflating media. A related method of making the valve device is also provided.

Abstract: A top nozzle is provided. The top nozzle can include a coupling plate, a perimeter wall and a hold-down spring unit. The coupling plate can be coupled to a guide thimble of the nuclear fuel assembly. The perimeter wall can protrude upwards from the perimeter of the coupling plate. A spring clamp can be provided on the upper surface of the perimeter wall. The hold-down spring unit can be mounted to the upper surface of the perimeter wall in such a way to couple a corresponding end of the hold-down spring unit to the spring clamp. A fastening pin hole can be vertically formed through an upper surface of the spring clamp. A spring insert hole into which the hold-down spring unit can be inserted and formed by electro-discharge machining in an insert direction of the hold-down spring.

Abstract: Systems, methods and apparatus for making a chemical head including forming a first return chamber in the chemical head, forming a second return chamber in the chemical head, forming a plurality of first return conduits from a head surface to the first return chamber, forming a plurality of second return conduits from a head surface to the second return chamber and wherein at least one of the first return conduits and the second return conduits being formed at a first angle relative to the head surface, the first angle being greater than about 20 degrees to a meniscus plane normal.

Abstract: The invention particularly relates to a tool set making it possible to introduce in a sheath (2) a flow-monitoring device (1) comprising a hollow body (11), a valve (12), a cup-type seal member (13), and a plurality of retention elastic legs (14). This tool set comprises three tools (3, 4, 5), whereof the first tool is formed of a contention bushing (31) and an ejecting pusher (32), whereof the third tool (5) receives the sheath (2) and comprises a cylinder (51) wherein a centering piston (51) slides in the sheath, and whereof the second tool (4) shaped like a funnel, is inserted between the first tool (3) and the third tool (5), and makes it possible to radially compress the seal (13) and the legs (14) of the device (1) while inserting them into the sheath (2) while this device is pushed out of the first tool.

Abstract: A case member includes a first surface and a second surface which have different heights that are adhered to a head main body, that is, another member, and an absorption member that is made of a material having elasticity and absorbs an adhesive is interposed between the second surface and a protection substrate while the first surface is adhered to a communication plate.

Abstract: According to one embodiment, an inkjet head comprises a substrate, and a nozzle plate. The substrate includes grooves. The nozzle plate includes nozzles that are formed by laser processing to communicate with the grooves. Electrodes are formed on respective internal surfaces of the grooves. Each of the electrodes is formed of a plurality of metal layers, and includes a flat surface that is apart from the internal surfaces of the grooves. A first inorganic film is superposed on the surfaces of the electrodes. A second inorganic film is superposed on the first inorganic film.

Abstract: A wireline or drill pipe retrievable coring tool with an inner barrel to receive a core, a bottom coring tool valve operable to seal off a bottom of the inner barrel and at least one pressure canister operable to receive fluid from the core in the inner barrel. The pressure canister is operable to significantly reduce the pressure inside the inner barrel utilizing an expandable chamber to receive fluid from the core as the tool is removed from the wellbore. In one embodiment, a bottom valve mechanism moves the cored formation materials out of the way of the bottom valve before the bottom valve is closed.

Abstract: A molded waterway assembly for a centerset faucet including a hot water inlet tube, a cold water inlet tube, and a central body of a coupler overmolded within hot and cold water bodies of the coupler.

Abstract: A system and method for remediating a body of water and collecting suspended and dissolved solids therefrom are provided. The system includes a water-impervious lining positionable in a depression in or adjacent a body of water. The lining and depression define a treatment vessel, which includes a treatment portion, an outlet portion for containing treated water, and an outflow weir between the treatment portion and the outlet portion. Water to be treated is transported from the water body to the treatment portion. An entrapment element is delivered and mixed into the transported water, the entrapment element for capturing suspended and dissolved solids in the transported water and effecting a separation between the captured solids and water cleansed therefrom. The captured solids can be removed from the treatment basin, and the cleansed water can move through a channel in the outflow weir into the outlet portion.

Abstract: A method for producing at least one deformable membrane micropump including a first substrate and a second substrate assembled together, the first substrate including at least one cavity and the second substrate including at least one deformable membrane arranged facing the cavity. In the method: the cavity is produced in the first substrate; then the first and second substrates are assembled together; then the deformable membrane is produced in the second substrate.

Abstract: An infusion device for subcutaneously administering a medication or a therapeutic fluid to a patient includes a base element which has fluid receiving means for receiving the fluid and fluid communication means for transferring the fluid into a cannula. The base element has at least one recess accommodating a septum that is pierceable by a needle. The septum is secured to the base element by a septum housing in such a way that a fluid transfer volume is formed in the recess between an internal surface of the septum and an inner section of the recess. The fluid transfer volume is in communication with the fluid communication means, and the septum housing accommodates a premounted septum. The septum housing is fixed and fluid sealed to the base element in the inner section of the recess.

Abstract: The present invention provides a loading element for reversibly coupling a microfluidic or nanofluidic cartridge to a processing apparatus wherein the loading element comprises: (a) a first connector part comprising a first set of air inlet ports and a first set of air outlet ports; (b) a second connector part comprising a second set of air inlet ports and a second set of air outlet ports; and (c) a guide part configured to guide the cartridge into reversible coupling with the loading element.