With Sample Resonant Frequency And Temperature Interdependence Patents (Class 324/315)
-
Patent number: 12092711Abstract: In a general aspect, a sample holder has multiple sample containers. In some instances, the sample holder can be received into a resonator package in a primary magnetic field of a magnetic resonance system. The resonator package includes a resonator configured to interact with a sample in a sample region. The sample holder includes a first sample and a calibration sample. The position of the sample holder relative to the resonator is calibrated. After calibrating the position of the sample holder, the sample holder is translated to position the first sample in the sample region. Magnetic resonance data is acquired based on magnetic resonance signals generated by an interaction between the resonator and the first sample.Type: GrantFiled: August 18, 2023Date of Patent: September 17, 2024Assignee: Quantum Valley Investment Fund LPInventors: Wei-Lin Ou, Troy W. Borneman, Derek Blair Poirier Thompson, Hamidreza Mohebbi, Andrew Boorn, Donald Edward Carkner
-
Patent number: 11971374Abstract: A method of using the transverse relaxation time (T2) of solvent NMR signal to detect filling errors of an alum-containing product in real-time and in-line during manufacturing, for example during a fill-finish unit operation. This method can be used for quality control in vaccine manufacturing to ensure the delivery of the correct concentration of alum-containing product to the product container such as a vial or pre-filled syringe.Type: GrantFiled: January 3, 2023Date of Patent: April 30, 2024Assignee: UNIVERSITY OF MARYLAND, BALTIMOREInventors: Yihua (Bruce) Yu, Marc B. Taraban
-
Patent number: 11624794Abstract: An automatic protocolling system and methods involving a processor operable by way of a set of executable instructions storable in relation to a nontransient memory device, the set of executable instructions configuring the processor to: receive information relating to an initial protocol comprising an initial ordering of a plurality of sequences, the information comprising data relating to an interaction extent value of at least one of an imaging system and a patient as a function of time corresponding to each sequence in the plurality of sequences, the data relating to a time-integrated effect of each sequence in the plurality of sequences; and dynamically determine an alternative protocol comprising an alternative ordering of the plurality of sequences based on the time-integrated effect, whereby an alternative protocol is provided.Type: GrantFiled: August 17, 2021Date of Patent: April 11, 2023Inventors: Chad Tyler Harris, Jeff Alan Stainsby, Andrew Thomas Curtis, Philip J. Beatty, Curtis Nathan Wiens
-
Patent number: 11543481Abstract: Magnetic resonance elastography (“MRE”), or other imaging-based elastography techniques, generate estimates of the mechanical properties, such as stiffness and damping ratio, of tissues in a subject. A machine learning approach, such as an artificial neural network, is implemented to perform an inversion of displacement data in order to generate the estimates of the mechanical properties.Type: GrantFiled: November 19, 2018Date of Patent: January 3, 2023Assignee: Mayo Foundation for Medical Education and ResearchInventors: Matthew C. Murphy, Richard L. Ehman, Kevin J. Glaser, Joshua D. Trzasko, Armando Manduca, John Huston, III, Jonathan M. Scott, Arvin Forghanian-Arani
-
Patent number: 11543371Abstract: A method of using the transverse relaxation rate (R2) of solvent NMR signal to detect filling errors of an alum-containing product in real-time in-line during manufacturing, for example during a fill-finish unit operation. This technique can be used for quality control in vaccine manufacturing to ensure the delivery of the correct concentration of alum-containing product to the product container such as a vial or pre-filled syringe.Type: GrantFiled: September 23, 2020Date of Patent: January 3, 2023Assignee: UNIVERSITY OF MARYLAND, BALTIMOREInventors: Yihua (Bruce) Yu, Marc B. Taraban
-
Patent number: 11484207Abstract: The present disclosure provides a method for determining an ultrasound focus location in a thermal image. In one aspect, the method includes obtaining a magnetic resonance thermal image of a tissue heated by a focused ultrasound and correcting a chemical shift and a k-space shift of a monitored ultrasound focus location in the magnetic resonance thermal image such that the monitored ultrasound focus location is aligned with a real physical ultrasound focus location. Correcting the chemical shift includes correcting a first spatial error of the monitored ultrasound focus location caused by resonance frequency changes of hydrogen nuclei due to environmental differences of water molecules. Correcting the k-space shift includes correcting a second spatial error of the monitored ultrasound focus location caused by temperature error due to spatial variations of a primary magnetic field.Type: GrantFiled: March 22, 2019Date of Patent: November 1, 2022Assignee: Soochow UniversityInventor: Chang-Sheng Mei
-
Patent number: 11137458Abstract: A rotor housing assembly for NMR spectroscopy. An elongate rotor has a distal drive end, a proximal end and an internal sample space positioned along its length between the drive and proximal ends. The rotor is driveable about a rotation axis by a drive gas flow. A rotor housing has an interior space in which the rotor is at least partially received. At least one first heated gas flow inlet is positioned opposite the internal sample space, through which a first heated gas flow is controllably flowable into the interior space to heat it and the rotor. At least a pair of spaced apart second heated gas flow outlets are axially spaced from the first heated gas flow inlet to controllably convey a second heated gas flow to heat distal and proximal areas of the sample space to minimize a temperature gradient extending axially within the sample space.Type: GrantFiled: May 29, 2020Date of Patent: October 5, 2021Assignee: Battelle Memorial InstituteInventors: Hardeep S. Mehta, Jesse A. Sears, Jr., Eric D. Walter, Nancy M. Washton, Karl T. Mueller, Ying Chen
-
Patent number: 11137443Abstract: Systems for probing superconducting circuits, including using a non-magnetic cryogenic heater, are disclosed. A system including a circuit board having a socket and a heater, mounted on the socket, is provided. The heater includes a resistive element and an arrangement for connection with wires configured to supply a current to the resistive element, where the heater is non-magnetic. The system further includes an integrated circuit package, mounted on the socket, such that the heater is located between the socket and the package, where the integrated circuit comprises superconducting circuits having a first temperature corresponding to a superconducting transition temperature. The heater is configured to raise a temperature associated with the integrated circuit from a second temperature to the first temperature, where the second temperature is lower than the first temperature, and where each of the first temperature and the second temperature is a cryogenic temperature.Type: GrantFiled: July 11, 2019Date of Patent: October 5, 2021Assignee: Microsoft Technology Licensing, LLCInventors: Miriam E. Marizan, Edward M. Kurek
-
Patent number: 11119169Abstract: System and methods that reconstruct absolute temperature using a multi-nuclear approach. Specifically, the methods and systems utilize independent NMR/MRI information provided by the precession frequency of two different nuclei to reconstruct a map of the absolute temperature.Type: GrantFiled: April 9, 2020Date of Patent: September 14, 2021Assignee: New York UniversityInventors: Leeor Alon, Guillaume Madelin, Emilia Silletta, Alexej Jerschow
-
Patent number: 11112469Abstract: A method for control of a radio-frequency amplifier of a magnetic resonance system is provided. The method includes determining a radio-frequency power to be output by the radio-frequency amplifier during an examination of a patient in the magnetic resonance system. Using a Lambert W function, a maximum temperature in tissue of the patient is determined as a function of the radio-frequency power. The radio-frequency amplifier is set as a function of the maximum temperature.Type: GrantFiled: October 10, 2019Date of Patent: September 7, 2021Assignee: Siemens Healthcare GmbHInventor: Volker Schnetter
-
Patent number: 11079452Abstract: Some aspects of the present disclosure relate to systems and methods for magnetic resonance thermometry. In one embodiment, a preliminary balanced steady state free precession (bSSFP) magnetic resonance imaging pulse sequence is applied to an area of interest of a subject. Based on bSSFP image phases, a relationship between frequency and image phase associated with the area of interest can be determined and a bSSFP magnetic resonance imaging pulse sequence applied for temperature change measurement during and/or after focused energy is applied to the subject. Based on image phase change associated with temperature change and using the determined relationship between frequency and image phase, a change in the resonance frequency associated with the target area due to the application of the focused energy can be determined, and the temperature change can be determined based on the determined change in the resonance frequency.Type: GrantFiled: October 9, 2015Date of Patent: August 3, 2021Assignee: University of Virginia Patent FoundationInventors: Grady Wilson Miller, Yuan Zheng
-
Patent number: 11009572Abstract: A method and a system are disclosed for obtaining imaging data using a MRI system configured to provide accurate images with high Signal-to-Noise Ratio (SNR) using superconducting magnets with field strengths in the range of 0.5 Tesla (T) to 3 T. The MRI includes a scanning bore deployed within a Cryogen-Free (CF) conduction-cooled superconducting magnet. The CF may have two stages, in which one stage cools a radiation shield down to a mid-level temperature, such as 35-80 degrees Kelvin (K), and the second stage cools the cold-mass further down to about 3-6 degrees K. The two-stage CF cryocooloer is used to cool target bodies of the superconducting magnet system and the receiving RF coil to create a higher SNR relative to when RF coils are not cooled. Sapphire sheets or bars may be used to cool the RF coils because sapphire conducts heat but not electricity, reducing electrical noise.Type: GrantFiled: September 24, 2018Date of Patent: May 18, 2021Inventor: Shahin Pourrahimi
-
Patent number: 10845444Abstract: Disclosed is a system and method for estimating quantitative parameters of a subject using a magnetic resonance (“MR”) system using a dictionary. The dictionary may include a plurality of signal templates that sparsely sample acquisition parameters used when acquiring data. The acquired data is compared with the dictionary using a neural network. Thus, systems and methods are provided that are more computationally efficient, and have reduced data storage requirements than traditional MRF reconstruction systems and methods.Type: GrantFiled: January 16, 2018Date of Patent: November 24, 2020Assignee: The General Hospital CorporationInventors: Ouri Cohen, Bo Zhu, Matthew S. Rosen
-
Patent number: 10598740Abstract: A magnetic resonance imaging apparatus according to an embodiment includes a temperature sensor and a processing circuit. The temperature sensor acquires a temperature. The processing circuit calculates, based on information on an imaging sequence in which magnetic resonance imaging is to be performed, an estimated value of consumption energy of a gradient coil in a case when the imaging sequence is executed and calculates, based on the temperature acquired by the temperature sensor and the estimated value of the consumption energy, an estimated value of a temperature of the gradient coil, the temperature of the gradient coil undergoing changes as the imaging sequence is executed.Type: GrantFiled: July 29, 2016Date of Patent: March 24, 2020Assignee: Canon Medical Systems CorporationInventors: Yuki Takai, Naoyuki Furudate, Masaaki Nagashima, Yutaka Machii
-
Patent number: 10484583Abstract: Some embodiments include a camera of a mobile computing device. In some embodiments, the camera includes an autofocus coil for moving a lens module, a plurality of optical image stabilization coils, a driver circuit element, connected to the autofocus coil, for passing an alternating current waveform through the autofocus coil, and one or more measurement circuit elements, connected to respective ones of the plurality of the optical image stabilization coils, for measuring changes induced in currents in the respective ones of the plurality of the optical image stabilization coils by the waveform.Type: GrantFiled: August 12, 2016Date of Patent: November 19, 2019Assignee: Apple Inc.Inventors: Thomas M. Gregory, Albert A. Ho, Richard J. Topliss, Richard H. Tsai
-
Patent number: 10310523Abstract: A method for operating a temperature control apparatus for a medical examination device, in particular a magnetic resonance apparatus, wherein the medical examination device causes a heat input into the body of a patient to be examined during an examination procedure, and wherein the temperature control apparatus has at least one temperature modifier designed for controlling the temperature of the patient, at least one item of heat information that describes the heat balance of the patient is determined, in order to determine a control parameter for controlling at least one ambient parameter that describes the at least one temperature modifier by taking into account at least one ambient condition on the body of the patient, and at least one examination parameter that describes the examination procedure as the input variables of a heat balance model.Type: GrantFiled: February 9, 2017Date of Patent: June 4, 2019Assignee: Siemens Healthcare GmbHInventor: Volker Schnetter
-
Patent number: 10274634Abstract: The present invention provides a nuclear magnetic resonance logging instrument probe with double-layered magnets and an antenna excitation method, the nuclear magnetic resonance logging instrument probe includes: a probe framework and a shielding layer arranged in the probe framework; a plurality of main magnets are provided above and below the shielding layer, respectively; central axes of the main magnets are parallel with each other, and distances between the central axes of each of the main magnets and a central axis of the probe framework are the same; a distance between central axes of any two main magnets is not smaller than a first preset value; and an antenna is provided at outer side of each main magnety. In the present invention, circumferential recognizing capability of the nuclear magnetic resonance logging instrument probe can be improved and three-dimensional (radial, axial and circumferential) stratum detection can be achieved.Type: GrantFiled: September 7, 2016Date of Patent: April 30, 2019Assignee: CHINA UNIVERSITY OF PETROLEUM-BEIJINGInventors: Lizhi Xiao, Guangzhi Liao, Qunjie Du, Xin Li, Sihui Luo
-
Patent number: 10265016Abstract: A diagnostic imaging system (100) includes a magnetic resonance (MR) imaging system (110) for providing an image representation of at least a portion of a subject of interest (120), a hyperthermia device (111) for locally heating a target zone within the portion of the subject of interest (120), and one or more processors for controlling the MR imaging system (110) and the hyperthermia device (111). Correlating image representations obtained at different temperatures of the target zone provides information on temperature dependent changes of the metabolism of the subject of interest (120). A treatment module (146) applies a treatment to the subject of interest (120) for destroying cells within the target zone. The one or more processors control the treatment module (146) for applying the treatment based on diagnostic image representations obtained by the diagnostic imaging system (100).Type: GrantFiled: February 19, 2014Date of Patent: April 23, 2019Assignee: KONINKLIJKE PHILIPS N.V.Inventor: Erkki Tapani Vahala
-
Patent number: 10234518Abstract: An MR loop coil design incorporates a balun into the loop coil. With this approach, some components of the coil may be simultaneously part of the imaging coil and the balun. Further, with this approach the number of components used to build an MR coil may be reduced, which may result in a reduction in cost, weight and size. This MR loop coil design may also be used to build phased array coils from the smaller loop size. Such an approach may use small feeder circuit boards oriented generally perpendicular to the coil elements to reduce interactions between the feeder boards and the coils. Such feeder boards may also be made smaller than conventional feeder circuits because the integrated balun coil design may reduce the number of components needed to create balanced coils in the array.Type: GrantFiled: February 20, 2015Date of Patent: March 19, 2019Assignee: Children's Hospital Medical CenterInventors: Wolfgang Manfred Loew, Randy Otto Giaquinto, Charles Lucian Dumoulin
-
Patent number: 10228430Abstract: A method for the transmission/reception of RF signals for NMR measurements uses a heat exchanger (1) for cooling heat sources (5), the heat exchanger having a contact element (4.2) for thermal connection between a cryogenic fluid and the heat source, is characterized in that the heat exchanger comprises a container having an interior volume VB into which a first cryogenic fluid F1 that has a liquid component F1L and a gaseous component F1G flows through an inflow conduit (8) and from which a second cryogenic fluid F2 that has liquid component F2L and a gaseous component F2G flows out through an outflow conduit (9). The inflow conduit has a flow cross-section QZ and a circumference UZ from which an associated parameter VZ=4·Q2Z/UZ results, wherein VB>10·VZ, and the outflow conduit has a flow diameter QA wherein QA?QZ. The contact element is in close thermal contact with both the liquid volume component VL of the cryogenic fluid and with the heat source.Type: GrantFiled: June 5, 2014Date of Patent: March 12, 2019Assignee: Bruker BioSpin AGInventors: Marc A. Schnell, Marc Enrique Paredes, Cengiz Cetrefli, Philippe Stauffenegger, Daniel Marek
-
Patent number: 10180362Abstract: Systems, methods and computer-accessible mediums for determining a specific absorption rate (SAR) of a radio frequency (RF) radiation on an object(s) can be provided, which can, for example hardware arrangement configured to receive thermal information for a portion(s) of the at least one object, and determine the SAR based on the thermal information.Type: GrantFiled: May 8, 2014Date of Patent: January 15, 2019Assignee: New York UniversityInventors: Leeor Alon, Cem Murat Deniz, Gene Young Cho, Leslie F. Greengard
-
Patent number: 10175311Abstract: Method for operating a thermal insulation device (100) comprising a screen (101, 102, 103, 104) for insulating a first member (21) and/or a second member (20; 30; 16; 10; 30) from a thermal radiation, the method comprising: a heat-exchange step in which heat is exchanged between a stream of a fluid, notably a gas, and the screen, notably a step of transferring heat from the heat screen to the stream, and a use step in which the stream is used for guiding the first member (21) and/or for driving the movement of the first member and/or for exchanging heat with the first member, notably for cooling the first member.Type: GrantFiled: February 7, 2013Date of Patent: January 8, 2019Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Gaël De Paëpe, Eric Bouleau
-
Patent number: 10159424Abstract: In a method and medical imaging apparatus, for generating medical image data records, raw data of the examination object are acquired by operation of a medical imaging scanner, a reconstruction algorithm issued for reconstructing a medical image data record on the basis of raw data and of a value of a physiological parameter. At least two medical image data records are created by applying the reconstruction algorithm at least twice to the acquired raw data using a different virtual value of the physiological parameter each time. The at least two medical image data records are provided from the reconstruction computer.Type: GrantFiled: May 28, 2015Date of Patent: December 25, 2018Assignee: Siemens AktiengesellschaftInventors: Andreas Greiser, Peter Speier, Aurelien Stalder
-
Patent number: 10151852Abstract: The present invention provides a multi-azimuth nuclear magnetic resonance logging instrument and an antenna excitation method, the nuclear magnetic resonance logging instrument includes: a probe framework and a shielding layer arranged in the probe framework; a plurality of main magnets are provided above and below the shielding layer, respectively; central axes of the main magnets are parallel with each other, and distances between the central axes of each of the main magnets and a central axis of the probe framework are the same; a distance between central axes of any two main magnets is not smaller than a first preset value; and an antenna is provided at outer side of each main magnet, and a plurality of the antennas are fed independently. In the present invention, circumferential recognizing capability of the nuclear magnetic resonance logging instrument can be improved and three-dimensional (radial, axial and circumferential) stratum detection can be achieved.Type: GrantFiled: September 7, 2016Date of Patent: December 11, 2018Assignee: CHINA UNIVERSITY OF PETROLEUM-BEIJINGInventors: Lizhi Xiao, Guangzhi Liao, Xin Li, Feng Deng, Sihui Luo, Zhe Sun, Wei Liu, Weiliang Chen, Jie Wang
-
Patent number: 10126393Abstract: A method for magnetic resonance fingerprinting and to a magnetic resonance device is provided. The method for magnetic resonance fingerprinting includes the following method steps—detecting a magnetic resonance signal waveform of an examination area of an examination object by means of a magnetic resonance fingerprinting method, comparing the detected magnetic resonance signal waveform with a number of signal waveforms stored in a database, wherein a database value of at least one tissue parameter is assigned to each of the database signal waveforms, and determining a value of the at least one tissue parameter on the basis of the signal comparison, wherein an influence of a temperature of the examination object on the magnetic resonance signal waveform is taken into consideration in the further processing of the magnetic resonance signal waveform.Type: GrantFiled: July 27, 2015Date of Patent: November 13, 2018Assignee: SIEMENS AKTIENGESELLSCHAFTInventor: David Grodzki
-
Patent number: 10073153Abstract: A device for attaching and detaching a cryogenic probe to and from a nuclear magnetic resonance (NMR) spectrometer. The device permits the probe to be loaded in the spectrometer in a shortened time and achieves high measurement throughput. The device has loading platforms (11-1, 11-2) on which cryogenic probes (P1, P2) are loaded. Each loading platform has a horizontal drive mechanism, a vertical drive mechanism, and a spacing mechanism. The device further includes probe cooling devices (14-1, 14-2) for circulating a refrigerant to and from the cryogenic probes (P1, P2) via transfer tubes (12-1, 12-2) made of a flexible material, thus cooling the probes (P1, P2). A temperature-controlled gas feeder (18) supplies a temperature variable gas for temperature adjustment to the probes (P1, P2). A vacuum pumping system (15) evacuates the interiors of the probes (P1, P2) via vacuum pipes (17-1, 17-2) made of a flexible material.Type: GrantFiled: November 18, 2014Date of Patent: September 11, 2018Assignee: JEOL Ltd.Inventors: Masanori Hirose, Yoshiaki Yamakoshi, Masahide Nishiyama, Shinji Nakamura, Katsuyuki Toshima, Fumio Hobo, Terumasa Okada, Shigenori Tsuji, Ryoji Tanaka, Hiroto Suematsu
-
Patent number: 10037841Abstract: A magnetic field generating apparatus comprises two or more co-facing, coaxial magnetic field generators configured to generate equivalent magnetic fields directed toward a symmetrically central convergence plane; a magnetically shielding encasement configured to contain all of the associated magnetic fields generated by the coaxial magnetic field generators; and articulation frames and supports for positioning of the apparatus about a fixed point, wherein the generated magnetic fields are counter-rotated relative to one another.Type: GrantFiled: October 15, 2015Date of Patent: July 31, 2018Inventor: Vincent Suzara
-
Patent number: 9995802Abstract: The NMR analysis method for analyzing a solid sample positioned in a sample-holder (21) includes generation of a plurality of high-pressure gaseous flows (2, 3, 4) from at least one first source (1) of a high-pressure gas; cooling of the gaseous flows (2, 3, 4) in at least one heat exchanger (12) from a coolant gas (15) originating from at least one second source (11) of gas; and rotation of the sample-holder (21) by a first cooled high-pressure gaseous flow (2) and cooling of the sample-holder by a second cooled high-pressure gaseous flow (3).Type: GrantFiled: December 11, 2012Date of Patent: June 12, 2018Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVESInventors: Eric Bouleau, Gaël De Paëpe
-
Patent number: 9971003Abstract: A medical apparatus (300, 400, 500, 600) comprising a magnetic resonance imaging system (302). The medical apparatus further comprises a memory (332) storing machine readable instructions (352, 354, 356, 358, 470, 472, 474) for execution by a processor (326). Execution of the instructions causes the processor to acquire (100, 202) spectroscopic magnetic resonance data (334). Execution of the instructions further cause the processor to calculate (102, 204) a calibration thermal map (336) using the spectroscopic magnetic resonance data. Execution of the instructions further causes the processor to acquire (104, 206) baseline magnetic resonance thermometry data (338). Execution of the instructions further causes the processor to repeatedly acquire (106, 212) magnetic resonance thermometry data (340).Type: GrantFiled: March 2, 2012Date of Patent: May 15, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Max Oskar Köhler, Erkki Tapani Vahala, Kirsi Ilona Nurmilaukas
-
Patent number: 9877791Abstract: Systems and methods provide visualization of the projected results of an aesthetic treatment, such as facial skin therapy, using an image display device and a plurality of stored transformation instructions. The system receives an input image of a subject, such as a recent portrait photograph. The system determines the aesthetic treatment to apply, retrieves the associated transformation instructions, and transforms the input image with the transformation instructions to produce a modified image that represents changes to the subject's face that are expected to occur after the selected treatment. The system may include or access a virtual treatment visualization engine that stores transformation parameters describing changes to make to the input image based on the selected treatment and other input parameters. The transformation parameters may be obtained from a model that received the selected treatment. The system may determine similarities of the subject to the model.Type: GrantFiled: July 25, 2016Date of Patent: January 30, 2018Assignee: PERSAIS, LLCInventors: Michael H. Slayton, Vadim Kouklev
-
Patent number: 9872622Abstract: A magnetic resonance scanner (12) is configured for thermographic imaging. One or more processors (28) receive (56) thermal image data from the magnetic resonance scanner and reconstruct at least one thermal image in which each voxel includes a measure of temperature change. The one or more processors identify (58) thermally abnormal voxels. A display (44) displays at least one reconstructed image with the identified abnormal thermal locations.Type: GrantFiled: December 13, 2012Date of Patent: January 23, 2018Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Feng Huang, Arne Reykowski, George Randall Duensing
-
Patent number: 9864031Abstract: Nuclear magnetic resonance properties of a sample containing fast relaxation components are determined using direct detection of the longitudinal component of the nuclear magnetization. Excitation and detection can be performed in different frequency ranges, which enables short dead time of measurements. In some implementations a nuclear magnetic resonance apparatus can be configured for use in oil well logging.Type: GrantFiled: May 15, 2014Date of Patent: January 9, 2018Inventor: Arcady Reiderman
-
Patent number: 9835704Abstract: In an image creating device, an obtainer obtains the phase of a magnetic resonance signal generated from a target object upon application of a static magnetic field and a high-frequency magnetic field to the target object (step S102). A calculator calculates a change level of the obtained phase per a predetermined distance in a direction of the static magnetic field (step S103). A generator generates an image representing a positional distribution of a parameter depending on the calculated change level (step S106).Type: GrantFiled: March 30, 2013Date of Patent: December 5, 2017Assignee: National University Corporation HokkaidoInventors: Toru Yamamoto, Yuta Kobayashi
-
Patent number: 9808176Abstract: In magnetic resonance (MR) thermometry, first and second magnetic resonance data that are acquired sequentially, from which a phase shift is determined between a measurement phase and a reference phase. In a first region of an examined person, the measurement phase is determined from the second magnetic resonance data and the reference phase is determined from the first magnetic resonance data. In a second region of the examined person, both the reference phase and measurement phase are determined from the second magnetic resonance data. Techniques for reference-based magnetic resonance thermometry and reference-free magnetic resonance thermometry can be applied.Type: GrantFiled: March 20, 2014Date of Patent: November 7, 2017Assignee: Siemens AktiengesellschaftInventor: Patrick Gross
-
Patent number: 9726735Abstract: An NMR probe head (3) has a coil system (9) and a radial centering mechanism for a sample vial (4) having two centering devices spaced axially from each other to center the sample vial in the radial direction only. The first centering device (5) is disposed above the receiver coil system and at least one further centering device (6) is disposed axially above the coil system with an axial spacing (d) above the first centering device. The first and second centering devices restrict the radial scope for movement of the sample vial to such an extent that the sample vial cannot touch an endangered space (7) during the entire duration of transport of the sample vial to its measuring position, thereby precluding damage to the probe head components in the endangered space by the sample vial.Type: GrantFiled: June 17, 2014Date of Patent: August 8, 2017Assignee: Bruker BioSpin AGInventors: Daniel Schmidig, Danijela Al Adwan Stojilkovic, Dirk Wilhelm
-
Patent number: 9689942Abstract: NMR analyzers and associated methods, circuits and computer program products that allow NMR operation in fluctuating ambient temperature environments of at least +/?5 degrees F. in a relatively large operating temperature range, typically between about 60-85 degrees F.) with the ability to still generate accurate quantitative measurements using an electronically applied temperature sensitivity adjustment based on an a priori model of temperature sensitivity and a detected temperature proximate the NMR signal acquisition (e.g., scan). The clinical NMR analyzers can be remotely accessed to evaluate linearity and temperature compensation adjustments.Type: GrantFiled: June 27, 2012Date of Patent: June 27, 2017Assignee: LipoScience, Inc.Inventors: David R. Morgan, Elias J. Jeyarajah
-
Patent number: 9594132Abstract: A magnetic resonance imaging system (402, 500) includes magnetic field gradient coils (516), a gradient coil power supply (320, 424, 518), a processor (540), and a chiller (308, 526) for providing the coolant to the gradient coils. The magnetic resonance imaging system further includes a memory (546) for storing machine executable instructions (580, 582, 584, 586, 588, 590, 592). The instructions cause the processor to receive (100, 200) a pulse sequence (550), to generate (102, 202) the chiller control signals using the pulse sequence and a chiller thermal model (582) of the gradient coils and the coolant reservoir, and to send (104, 206) the chiller control signals to the chiller. The chiller control signals cause the chiller to halt chilling at least a portion of the time when the gradient coil power supply supplies current to the magnetic field gradient coils.Type: GrantFiled: March 23, 2012Date of Patent: March 14, 2017Assignee: KONINKLIJKE PHILIPS N.V.Inventor: Marinus Johannes Adrianus Maria Van Helvoort
-
Patent number: 9594131Abstract: New method of cooling of MRI coil and resonators is disclosed and described. MRI coil designs showed in the disclosure are based solely on the use of copper tube elements filled with liquid nitrogen. Inside the conducting tubes at rf frequency there is no rf electric field, thus the liquid nitrogen presence inside such coils will not have any influence on MRI coil dielectric losses and on the resonant frequency modulation. Liquid nitrogen cooled coils, when in the coil noise regime, demonstrate 2-3 gain of signal-to-noise ratio comparing with room temperature equivalent coils. Methods for making and using both superconducting and normal metal MRI coils and/or arrays in such configurations are also disclosed.Type: GrantFiled: May 11, 2012Date of Patent: March 14, 2017Assignee: THE UNIVERSITY OF HOUSTON SYSTEMInventors: Jarek Wosik, Krzysztof Nesteruk, Lei Ming (Patrick) P. Xie (Leiming)
-
Patent number: 9494663Abstract: An NMR spectrometer and method in the following three steps are performed. (1) An external magnetic field is set to H0+?H (where 4H>0). When the detection coil made of the superconducting material is still in a normal state, a magnetic field stronger than the ultimate target static magnetic field strength H0 by ?H is applied to the detection coil. (2) The detection coil made of the superconducting material is cooled down to T0 lower than its critical temperature Tc to bring the coil into a superconducting state while the external magnetic field H0+?H is applied to the detection coil. (3) The external magnetic field is lowered from H0+?H to H0 such that the applied external magnetic field is decreased by ?H while the detection coil is kept in the superconducting state.Type: GrantFiled: January 2, 2013Date of Patent: November 15, 2016Assignee: JEOL Ltd.Inventors: Shigenori Tsuji, Fumio Hobo, Ryoji Tanaka, Hiroto Suematsu
-
Patent number: 9465090Abstract: An MRI method (10) to map the temperature of a bodily tissue using measurements of the tissue density.Type: GrantFiled: June 2, 2011Date of Patent: October 11, 2016Assignee: Siemens AktiengesellschaftInventor: Atilla Peter Kiraly
-
Patent number: 9372247Abstract: An NMR (nuclear magnetic resonance) detection module (such as an NMR probe) mounted in a vacuum vessel permits a transmit/receive coil to be cooled efficiently and to be placed closer to a sample container. The NMR detection module includes a core module (detection module) (54) consisting of a refrigerant block (118) and a transmit/receive coil formed on the inner surface of a detection hole (130). A sleeve (cylindrical partition wall) (122) forming a part of the vacuum vessel is inserted in the detection hole (130). A sample tube (56) is inserted in the sleeve (122). The refrigerant block (118) is connected to a heat exchanger via a support member (82). Since it is not necessary to form a bobbin inside the transmit/receive coil, the distance between the coil and the sample can be set small. The coil is entirely surrounded by the refrigerant block.Type: GrantFiled: August 21, 2013Date of Patent: June 21, 2016Assignees: Kyoto University, JEOL Resonance Inc.Inventors: Kiyonori Takegoshi, Takashi Mizuno
-
Patent number: 9335389Abstract: A cooled NMR detection probe including a detection coil and an internal structure (65) mounted in a vacuum vessel (58) includes a radiation shield assembly (68), a connecting member (74), and a heat exchanger (80). The internal structure (65) is secured to the vacuum vessel (58) by a holding member (66). If the internal structure shrinks during cooling, the position of an upper portion of the first heat exchanger (80) hardly varies, thus suppressing displacement of a core module (54).Type: GrantFiled: August 21, 2013Date of Patent: May 10, 2016Assignees: Kyoto University, JEOL Resonance Inc.Inventors: Kiyonori Takegoshi, Takashi Mizuno
-
Patent number: 9271794Abstract: Image-guided therapy of a tissue can utilize magnetic resonance imaging (MRI) or another medical imaging device to guide an instrument within the tissue. A workstation can actuate movement of the instrument, and can actuate energy emission and/or cooling of the instrument to effect treatment to the tissue. The instrument can be an MRI compatible laser probe that provides thermal therapy to, e.g., a tissue in a brain of a patient. By tracking a probe position within tissue through feedback, multiple data slices provided around the probe position can be processed to monitor treatment and view thermal data. The operator selects treatment area reference points with the assistance of noise masking.Type: GrantFiled: December 1, 2014Date of Patent: March 1, 2016Assignee: MONTERIS MEDICAL CORPORATIONInventors: Richard Tyc, Salman Qureshi, Mark Andrew Grant, Luis Filipe Silva Fernandes, Daniel Prazeres Carreira, John Schellhorn
-
Patent number: 8989838Abstract: The present invention provides a method and apparatus for delivering and controlling thermal therapy to a volume of diseased tissue. Specifically, the invention includes using thermal imaging and other inputs to determine an acoustic (ultrasonic) treatment regime employing interstitial ultrasound applicators to deliver a required therapeutic temperature or thermal dose to the affected region in a body or organ. Various aspects of the treatment that can be controlled include individual transducer element operating power and frequency, as well as the rate of cooling and rotation of the entire applicator.Type: GrantFiled: July 6, 2010Date of Patent: March 24, 2015Assignee: Sunnybrook Health Sciences CentreInventors: Rajiv Chopra, Michael Bronskill, Mathieu Burtnyk
-
Patent number: 8862203Abstract: This disclosure employs temperature, magnetism and Curie point transition to construct and use catheters and other medical devices that can be visualized using magnetic resonance imaging (MRI). Accordingly, this disclosure includes, but is not limited to, medical devices, means of constructing medical devices, and methods of imaging medical devices using magnetic resonance and other technologies.Type: GrantFiled: March 27, 2003Date of Patent: October 14, 2014Assignee: Boston Scientific Scimed Inc.Inventor: Jan Weber
-
Patent number: 8847595Abstract: Temperature control device (20) for an NMR sample tube (22), wherein multiple interleaved, concentric flow channels (28, 31; 40, 41, 42; 50, 51) for temperature control fluid extending coaxially with respect to a cylindrical interior space (21) for holding the NMR sample tube are constituted around said interior space (21), wherein said temperature control device is constituted such that it is closed toward the interior space in an axial end region (26) and, an axial end region (23) at the opposite end thereto, open to the interior space for inserting the NMR sample tube into said interior space (21), wherein, in a counter flow region (GB), adjacent flow channels (28, 31; 40, 41, 42; 51) are interconnected through a fluid passage (34, 43, 44) at one axial end in such a way that the direction of a fluid flow in the flow channels of the counter flow region is reversed with respect to the corresponding adjacent flow channel in the counter flow region, wherein the outermost flow channel (28; 51) of the counter flType: GrantFiled: May 10, 2011Date of Patent: September 30, 2014Assignee: Bruker BioSpin AGInventors: Beat Grossniklaus, Federico Raffa, Markus Mayer, Dirk Wilhelm
-
Publication number: 20140285197Abstract: In magnetic resonance (MR) thermometry, first and second magnetic resonance data that are acquired sequentially, from which a phase shift is determined between a measurement phase and a reference phase. In a first region of an examined person, the measurement phase is determined from the second magnetic resonance data and the reference phase is determined from the first magnetic resonance data. In a second region of the examined person, both the reference phase and measurement phase are determined from the second magnetic resonance data. Techniques for reference-based magnetic resonance thermometry and reference-free magnetic resonance thermometry can be applied.Type: ApplicationFiled: March 20, 2014Publication date: September 25, 2014Inventor: Patrick Gross
-
Patent number: 8810246Abstract: Proton resonance frequency shift thermometry may be improved by combining multibaseline and referenceless thermometry.Type: GrantFiled: January 19, 2011Date of Patent: August 19, 2014Assignees: Insightec Ltd., The Board of Trustees of The Leland Stanford Junior UniversityInventors: William A. Grissom, Kim Butts Pauly, Michael Lustig, Yoav Medan, Yoav Levy, Viola Rieke
-
Patent number: 8797032Abstract: The temperature of an MRI gradient magnetic field coil unit is measured at least two times. Shift data indicating a center magnetic resonance frequency of a hydrogen atom in response to variation of the gradient coil temperature is stored in advance. Estimated shift of the center frequency based on the measurement result is determined and the center frequency of an RF NMR excitation pulse is corrected based on the estimated shift.Type: GrantFiled: July 1, 2011Date of Patent: August 5, 2014Assignees: Kabushiki Kaisha Toshiba, Toshiba Medical Systems CorporationInventor: Masashi Ookawa
-
Patent number: 8792961Abstract: In a method and magnetic resonance (MR) system to create an MR magnitude image data set and a phase image data set of an examination subject, first echo signals in a first raw MR data set are detected after a first echo time TE1 and at least second echo signals in at least one second raw MR data set are detected after a second echo time TE2 that is longer than TE1, a magnitude image data set is generated on the basis of the first raw MR data set and the at least one second raw MR data set with averaging of the first and the at least one second raw MR data set, and the phase image data set is generated based on the phase information contained in the at least two raw MR data sets, with averaging of the respective phase information contained in the at least two raw MR data sets.Type: GrantFiled: October 11, 2010Date of Patent: July 29, 2014Assignee: Siemens AktiengesellschaftInventors: Patric Gross, Joerg Roland