Using A Nuclear Resonance Spectrometer System Patents (Class 324/307)
  • Patent number: 11959982
    Abstract: A low-cost modular liquid nitrogen low-temperature multi-nuclear magnetic resonance probe includes a Dewar, a pluggable coil and a front-end gain amplifier. The Dewar includes a cylindrical sandwich chamber, the center of the cylindrical sandwich chamber constitutes a room-temperature chamber, a sandwich of the cylindrical sandwich chamber is divided into a vacuum chamber and a liquid nitrogen chamber by a liquid nitrogen vessel wall, the vacuum chamber is located between the room-temperature chamber and the liquid nitrogen chamber, the pluggable coil and the front-end gain amplifier are provided in the vacuum chamber, the pluggable coil comprises a coil portion and a pluggable base, the coil portion is in pluggable connection with the pluggable base, and the pluggable coil is connected with the front-end gain amplifier. The probe realizes the transmission of radio frequency pulses and the reception of magnetic resonance signals, and is applicable to whole-body imaging of a small animal.
    Type: Grant
    Filed: November 10, 2021
    Date of Patent: April 16, 2024
    Assignee: INNOVATION ACADEMY FOR PRECISION MEASUREMENT SCIENCE AND TECHNOLOGY, CAS
    Inventors: Zhi Zhang, Qingjia Bao, Chaoyang Liu, Xinjie Liu, Fang Chen, Jiaxin Wang, Xin Cheng, Maili Liu
  • Patent number: 11960859
    Abstract: A method for discovering optimal algorithms is provided. The method comprises defining a starting condition for a program defining a number of program targets, wherein the program targets map program user-specified inputs to expected outputs, defining a number of program objectives, and defining a number of program constraints. An iterative optimization problem is then initialized to solve for the resulting program. A determination is made if defined termination conditions have been met according to the program targets and optimization objectives. Responsive to the defined termination conditions not being met an update to the program is selected by addition or subtraction of operations, the updated program is evaluated according to the program targets, the number of program objectives are evaluated, and the optimization problem is re-iterated. Responsive to the defined termination conditions being met, the program is reassembled into an instruction set.
    Type: Grant
    Filed: November 12, 2021
    Date of Patent: April 16, 2024
    Assignee: The Boeing Company
    Inventor: Richard Joel Thompson
  • Patent number: 11938200
    Abstract: The present disclosure relates to magnetic resonance imaging (MRI) methods comprising (i) obtaining a baseline chemical exchange saturation transfer (CEST) MRI image of a patient, (ii) administering an effective amount of a non-nutritive sweetener to the patient, and (iii) obtaining one or more test CEST MRI image of the patient subsequent to the administering step (ii); wherein the step (i) and (iii) acquisition parameters are substantially the same. The non-nutritive sweetener may include a natural or artificial sugar alcohol, polyol, or combinations or derivatives thereof.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: March 26, 2024
    Assignees: The Trustees of the University of Pennsylvania, Sidra Medicine
    Inventors: Ravinder Reddy, Mohammad Haris, Hari Hariharan, Puneet Bagga, Francesco M. Marincola, Mitchell D. Schnall
  • Patent number: 11940518
    Abstract: The disclosure relates to a technique for providing an image of diagnostically relevant area of a jaw region of a patient by means of a magnetic resonance apparatus by capturing information about the jaw region of the patient, which comprises at least one reference to a position and/or an extent of the diagnostically relevant area of the jaw region. The technique also includes adjusting a parameter of a magnetic resonance measurement as a function of the captured information about the jaw region of the patient, carrying out the magnetic resonance measurement with the adjusted parameter, capturing image data of the jaw region of the patient, reconstructing an image of the diagnostically relevant area of the jaw region as a function of the captured image data, and providing the image of the diagnostically relevant area of the jaw region of the patient.
    Type: Grant
    Filed: March 25, 2022
    Date of Patent: March 26, 2024
    Assignee: Siemens Healthineers AG
    Inventors: Andreas Greiser, Carmel Hayes, Mario Zeller
  • Patent number: 11930894
    Abstract: The present application discloses a pluggable connecting buckle, including a male buckle and a female buckle. A first connecting rod is arranged on one end of the male buckle, and a decorative plate and a buckling rib are arranged on an other end. A buckling block is arranged on the buckling rib, and a corresponding engagement groove is arranged on the buckling rib. A second connecting rod and an accommodating cavity are respectively arranged on two ends of the female buckle. Two engagement assemblies are respectively arranged on two sides of the accommodating cavity. A limiting plate is arranged on the engagement assembly which includes a turning plate. An inclined engagement surface is arranged on the engagement groove, and an inverted hook plane is arranged on the turning end of the turning plate. The pluggable connecting buckle has a good anti-loosening effect, a long service life, and good user experience.
    Type: Grant
    Filed: February 16, 2023
    Date of Patent: March 19, 2024
    Assignee: Foshan Tuorun Precision Hardware Technology Co., Ltd
    Inventor: Maoyang Gao
  • Patent number: 11927660
    Abstract: A method for determining movement of an object to be imaged in a medical imaging method which includes at least one Magnetic Resonance Imaging, wherein the method comprises the following steps determining first coefficients of a mathematical transformation based on first navigator data of the object, wherein the first navigator data are recorded by a magnetic resonance tomograph (100) using a first spherical Lissajous navigator in the k-space with kr<0.2/cm, preferably kr<0.15/cm, and particularly preferably kr<0.1/cm, wherein kr represents the absolute value of the wave vector k.
    Type: Grant
    Filed: May 22, 2019
    Date of Patent: March 12, 2024
    Assignee: FORSCHUNGSZENTRUM JÜLICH GMBH
    Inventors: Richard Buschbeck, Nadim Joni Shah
  • Patent number: 11914016
    Abstract: The invention relates to a method of MR imaging of an object (10). It is an object of the invention to enable MR imaging using radial acquisition with a reduced level of phase distortions and corresponding image artefacts. The method of the invention comprises the steps of: a) generating MR signals by subjecting the object to an imaging sequence comprising RF pulses and switched magnetic field gradients; b) acquiring the MR signals as radial k-space profiles, wherein pairs of spatially adjacent k-space profiles are acquired in opposite directions and wherein k-space profiles acquired in temporal proximity are close to each other in k-space; c) reconstructing an MR image from the acquired MR signals. Moreover, the invention relates to a MR device (1) and to a computer program for a MR device (1).
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: February 27, 2024
    Assignee: Koninklijke Philips N.V.
    Inventors: Guruprasad Krishnamoorthy, Gabriele Marianne Beck
  • Patent number: 11896392
    Abstract: Systems and methods are provided for determine the fat composition in an organ of interest using a non-invasive health measurement system. The non-invasive health measurement system may include an open magnet NMR apparatus. The NMR apparatus may measure NMR signals in a sensitive volume of a patient. The sensitive volume may coincide with an organ of interest, such as a liver. Systems and methods disclosed herein may provide for separation of the water contribution and the fat contribution to the measured NMR signal. Diffusion based separation, T2 based separation, and T1 based separation may each serve as different methods for separating the water and fat contributions to the signal. Separating the water and fat contributions to the single may allow for computation of a proton density fat fraction which may reflect the fat composition of the organ of interest.
    Type: Grant
    Filed: March 10, 2022
    Date of Patent: February 13, 2024
    Assignee: Livivos Inc.
    Inventors: Pablo Jose Prado, Alejandro Bussandri
  • Patent number: 11898976
    Abstract: A method for determining the pore types of a core sample can include: determining a porosity of a core sample, wherein the core sample has a permeability of 10 mD or less; saturating the core sample with a NMR saturation fluid to achieve a saturated core sample; taking a NMR measurement of fluids in the saturated core sample; and deriving a volume for a pore type based on the porosity based on a correlation between the NMR measurement and a NMR signal to fluid volume calibration, wherein the pore type is selected from the group consisting of a nanopore, a micropore, a macropore, and any combination thereof.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: February 13, 2024
    Assignee: ExxonMobil Technology and Engineering Company
    Inventors: Pavel Kortunov, Hubert E. King, Harry W. Deckman
  • Patent number: 11878188
    Abstract: Devices, systems, and methods for enhancing MRI image quality and tracking accuracy in MR-guided treatment systems are described.
    Type: Grant
    Filed: May 3, 2022
    Date of Patent: January 23, 2024
    Assignee: Washington University
    Inventors: H. Michael Gach, Austen Curcuru, Taeho Kim, Umberto Villa
  • Patent number: 11874347
    Abstract: A method for shaping an RF pulse for use with an MRI system includes shaping an RF pulse for use with an MRI system that uses an RF coil. The RF pulse is shaped to reduce changes in B1 amplitude and in an off-resonance effect with respect to Larmor frequency as a function of distance from the RF coil.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: January 16, 2024
    Assignee: Clear-Cut Medical Ltd.
    Inventors: Saul Stokar, Tal Bareket, Zachi Peles
  • Patent number: 11857356
    Abstract: A method is disclosed for recording medical images of the human body or that of an animal. The method includes scanning for acquiring data and signaling the start and/or end of a manual administration of a contrast medium in temporal relation to the scan for acquiring data.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: January 2, 2024
    Assignee: SIEMENS HEALTHCARE GMBH
    Inventors: Johannes Georg Korporaal, Rainer Raupach
  • Patent number: 11849885
    Abstract: A grinder comprises a bearing track and a plurality of bearing elements such as ball bearings or roller bearings. Optionally, the bearing elements are protected from fouling or contamination from the material being ground, which can be, for example, herbs, spices, tobacco, or cannabis.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: December 26, 2023
    Inventor: Amit Gorodetzer
  • Patent number: 11841413
    Abstract: The present application provides a system and method for using a nuclear magnetic resonance (NMR) system. The method includes performing a pulse sequence using the NMR system that spatially encodes NMR signal evolutions to be acquired from a subject using an aggregated radio-frequency (B1) field incoherence and resolving the NMR signal evolutions acquired from the subject using at least one of a dictionary of known magnetic resonance fingerprinting (MRF) signal evolutions to determine matches in the NMR signal evolutions to the known MRF signal evolutions or an optimization process. The method also includes generating at least two spatially-resolved measurements indicating quantitative tissue parameters of the subject in at least two locations.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: December 12, 2023
    Assignees: Case Western Reserve University, Vanderbilt University
    Inventors: Mark A. Griswold, William A. Grissom
  • Patent number: 11815481
    Abstract: A method for determining the porosity of a core sample can include: saturating a core sample with a nuclear magnetic resonance (NMR) saturation fluid, wherein the core sample has a permeability of 100 milliDarcy (mD) or less, to achieve a saturated core sample; taking a NMR measurement of fluids in the saturated core sample; determining a porosity of the core sample based on a correlation between the NMR measurement and a NMR signal to fluid volume calibration.
    Type: Grant
    Filed: March 19, 2020
    Date of Patent: November 14, 2023
    Assignee: ExxonMobil Technology and Engineering Company
    Inventors: Hubert E. King, Pavel Kortunov, Harry W. Deckman, Shreerang S. Chhatre, Hemantkumar R. Sahoo, Antonio S. Buono
  • Patent number: 11815577
    Abstract: The invention relates to a method of MR imaging of an object (10) placed in an examination volume of a MR device (1). The method comprises the steps of: —generating MR signals by subjecting the object to an imaging sequence, —acquiring MR signal profiles in a Cartesian k-space sampling scheme, wherein each MR signal profile is acquired in the presence of a temporally constant magnetic field gradient along a readout direction and a sinusoidally modulated magnetic field gradient along a phase encoding direction, and—reconstructing an MR image from the acquired MR signal profiles taking the modulation scheme of the magnetic field gradients into account. The invention proposes that the frequency of the sinusoidal modulation of the magnetic field gradient is varied during acquisition of each MR signal profile. Moreover, the invention relates to a MR device for carrying out this method as well as to a computer program to be run on a MR device.
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: November 14, 2023
    Assignee: Koninklijke Philips N.V.
    Inventors: Zechen Zhou, Peter Bornert
  • Patent number: 11800978
    Abstract: A computer-implemented method of performing deep learning based isocenter positioning includes acquiring a plurality of slabs covering an anatomical area of interest that comprises a patient's heart. For each slab, one or more deep learning models are used to determine a likelihood score for the slab indicating a probability that the slab includes at least a portion of the patient's heart. A center position of the patient's heart may then be determined based on the likelihood scores determined for the plurality of slabs.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: October 31, 2023
    Assignee: Siemens Healthcare GmbH
    Inventors: Xiaoguang Lu, Carmel Hayes
  • Patent number: 11802925
    Abstract: A magnetic resonance imaging (MRI) system with low-power miniaturization, a power supply system, and a power management system are provided. The MRI system includes: a permanent magnet using samarium-cobalt material, an MR console, a transmission RF chain, a receiving RF chain, gradient coils, gradient amplifiers, and a terminal device for user interactions. Each of above systems is a ultra-light and ultra-low-power ultra-low field brain MRI system for highly accessible healthcare applications.
    Type: Grant
    Filed: October 29, 2021
    Date of Patent: October 31, 2023
    Assignee: CHENGDU YIJIAN MEDICAL TECHNOLOGY CO., LTD
    Inventors: Ruixing Zhu, Zhizun Zhang, Hangxuan Li
  • Patent number: 11796619
    Abstract: Methods of assessing or obtaining an indication of the presence of a cognitive disorder by analysing microstructural changes in regions of the brain are provided. The invention particularly relates to methods of assessing or obtaining an indication of the presence of types of dementia, for example Alzheimer's disease, by analysing changes in minicolumns in regions or layers of the cortex of the brain or of the whole brain.
    Type: Grant
    Filed: December 8, 2020
    Date of Patent: October 24, 2023
    Assignee: Oxford University Innovation Limited
    Inventors: Steven Chance, Rebecca McKavanagh, Mark Jenkinson, Karla Miller
  • Patent number: 11796616
    Abstract: A method of performing multidimensional magnetic resonance imaging on a subject comprises collecting imaging data for a region of interest of the subject, the imaging data related to one or more spatially-varying parameters of the subject within the region of interest; collecting auxiliary data for the region of interest in the subject, the auxiliary data related to one or more time-varying parameters of the subject within the region of interest; linking the imaging data and the auxiliary data; and constructing an image tensor with one or more temporal dimensions based on at least a portion of the linked imaging data and at least a portion of the linked auxiliary data.
    Type: Grant
    Filed: May 28, 2021
    Date of Patent: October 24, 2023
    Assignee: CEDARS-SINAI MEDICAL CENTER
    Inventors: Debiao Li, Anthony Christodoulou, Zhaoyang Fan, Zixin Deng, Nan Wang, Zhengwei Zhou, Sen Ma, Christopher Nguyen, Yibin Xie, Jaime Shaw
  • Patent number: 11796617
    Abstract: A method for k-space registration is provided. The method of k-space registration includes receiving a first partial k-space dataset for an object and a second partial k-space dataset for the object, selecting the first partial k-space dataset as a reference, selecting feature for estimating a transformation matrix for transforming k-space data, estimating a transformation matrix based on the feature of entire or part of the first partial k-space dataset and the feature of the second partial k-space dataset corresponding to the entire or part of the first partial k-space dataset, correcting the second partial k-space dataset based on the transformation matrix, and obtaining the corrected second partial k-space dataset. The present method is further used for partial Fourier reconstruction.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: October 24, 2023
    Assignees: University of Cincinnati, Children's Hospital Medical Center
    Inventors: Jinghua Wang, Lili He
  • Patent number: 11779258
    Abstract: A peripheral nerve conduction diagnosis system that utilizes an electrostimulation device having dry elastomer electrodes and a distance measuring device that allow a user to move the electrostimulation device along the skin of a patient while in constant contact with the skin and measure the distance moved.
    Type: Grant
    Filed: June 13, 2016
    Date of Patent: October 10, 2023
    Inventor: Tomasz Andrzej Kosierkiewicz
  • Patent number: 11774383
    Abstract: The present invention relates to a method based on proton NMR technique to differentiate genuine and spurious Hand-rub formulations. This method identifies and estimates all four components present in WHO-recommended Hand-rub formulations. Further, this method also identifies the presence of non-recommended/additional components present in WHO-recommended Hand-rub formulations. The method described in this invention utilizes experimental parameters and derived equations to quantify all four components in just fifteen minutes without using any organic solvents.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: October 3, 2023
    Assignee: INDIAN OIL CORPORATION LIMITED
    Inventors: Ravindra Kumar, Sujit Mondal, Christopher Jayaraj, Gurpreet Singh Kapur, Sankara Sri Venkata Ramakumar
  • Patent number: 11768257
    Abstract: Improved magnetic resonance imaging systems, methods and software are described including a low field strength main magnet, a gradient coil assembly, an RF coil system, and a control system configured for the acquisition and processing of magnetic resonance imaging data from a patient while utilizing a sparse sampling imaging technique.
    Type: Grant
    Filed: June 23, 2022
    Date of Patent: September 26, 2023
    Assignee: VIEWRAY TECHNOLOGIES, INC.
    Inventor: James F. Dempsey
  • Patent number: 11747422
    Abstract: An approach to estimate noise, Rician signal bias and true signal in magnitude signal data obtained with magnetic resonance imaging. The method uses multiple measurements at different scan parameter settings, also referred to as weightings, and an iterative algorithm to estimate noise, expected signal and associated Rician signal bias. Measurements at all measured weighting levels contribute to the ultimate estimation of the bias-free signal decay function. Therefore, of the so processed magnetic resonance image data, weighted signals can be computed at arbitrary weighting levels and with considerably better signal-to-noise ratio than the originally obtained data at corresponding weightings. Bias-free weighted image data at desired weighting levels, maps of the decay function fit parameters, or maps of a combination of such decay function parameters can be used for rapid and highly sensitive tissue characterization.
    Type: Grant
    Filed: October 18, 2021
    Date of Patent: September 5, 2023
    Inventor: Stephan Maier
  • Patent number: 11733336
    Abstract: A method a for acquiring magnetic resonance data of an object under examination by means of a magnetic resonance system comprises: in an excitation phase, applying an RF excitation pulse; in a wait phase following the excitation phase, applying at least one first RF refocusing pulse after the applied RF excitation pulse according to a first echo spacing; in an acquisition phase following the wait phase, applying at least two further RF refocusing pulses to generate echo signals according to a second echo spacing, wherein the second echo spacing is smaller than the first echo spacing; and reading out the echo signals generated in the acquisition phase as magnetic resonance data from which image data can be reconstructed, wherein in the wait phase at least two spoiler gradients are switched in the readout direction.
    Type: Grant
    Filed: September 27, 2021
    Date of Patent: August 22, 2023
    Assignee: Siemens Healthcare GmbH
    Inventors: Nadine Dispenza, Dominik Paul, Mario Zeller
  • Patent number: 11733338
    Abstract: An MRI phantom having an MRI compatible temperature measurement device having an MRI compatible body containing an MRI compatible fluid, wherein the device senses accurate temperature measurement within an MR Scanner environment using image processing of the contrast in signal between the areas of the image around the device and the fluid contained within the body of the device. The MRI Phantom may further include an internal expansion bladder device accomodating internal changes in pressure within the phantom, wherein the internal expansion bladder device includes frames supporting a pair of spaced membranes defining a chamber filled with a compressible gas.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: August 22, 2023
    Assignees: PSYCHOLOGY SOFTWARE TOOLS, INC, UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
    Inventors: Anthony P. Zuccolotto, John Dzikiy, Leroy K. Basler, Benjamin A. Rodack, Walter Schneider, Sudhir K. Pathak, Michael A. Boss
  • Patent number: 11733334
    Abstract: A method of magnetic resonance (MR) imaging includes a phantom that is inexpensive to produce and enables simple, practical and fast assessment of image sharpness, in particular for checking image quality of MR imaging with spiral acquisition. The method includes subjecting a phantom, which comprises a volume filled with a bulk of granules of solid material surrounded by a liquid, to an imaging sequence, acquiring MR signals from the phantom, reconstructing an MR image from the acquired MR signals, and deriving a measure of the local image sharpness in two or more different image regions from the MR image, wherein each image region is a representation of a part of the phantom volume.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: August 22, 2023
    Assignee: Koninklijke Philips N.V.
    Inventors: Miha Fuderer, Silke Hey
  • Patent number: 11733330
    Abstract: The disclosure relates to a magnetic resonance tomography scanner and to a method for operating the magnetic resonance tomography scanner. The method includes determining a B0 field map. The method further includes determining an excitation of the nuclear spins to be achieved and a spectrally selective excitation pulse for transmission by a transmitter by way of an antenna as a function of the B0 field map. In the method, the excitation pulse is configured here to generate the excitation of the nuclear spins to be achieved in the patient. The excitation pulse is then output by way of the antenna.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: August 22, 2023
    Assignee: Siemens Healthcare GmbH
    Inventors: David Grodzki, Michael Köhler, Dieter Ritter
  • Patent number: 11726157
    Abstract: A method for denoising magnetic resonance images and data is disclosed herein. An example method includes receiving a series of MRF images from a scanning device; identifying one or more subsets of voxels for the series of MRF images; generating one or more sets of eigenvectors, each set of the one or more sets of eigenvectors corresponding to one of the one or more subsets of voxels, and each eigenvector of the one or more sets of eigenvectors having a corresponding eigenvalue; applying a noise distribution model to each of the eigenvalues; identifying a subset of the eigenvalues as corresponding to noise based on the noise distribution model; and reconstructing the series of MRF images without the subset of eigenvalues identified as corresponding to noise.
    Type: Grant
    Filed: November 15, 2021
    Date of Patent: August 15, 2023
    Assignee: REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Matthew Zhu, Yun Jiang
  • Patent number: 11728038
    Abstract: Methods, computer-readable storage media and systems are described for constructing a three-dimensional electronic library of simulated decays of the diffusion-weighted 1H2O MR signal in b-space. Methods, computer-readable media, and systems are described for preparing a parametric tissue map for tissue in a subject. Computer readable media, having an electronic library of simulated decays of the diffusion-weighted 1H2O signal in b-space and method of using such a library.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: August 15, 2023
    Assignee: OREGON HEALTH & SCIENCE UNIVERSITY
    Inventors: Charles Springer, Gregory Wilson, Jeffrey Maki, Thomas Barbara, Xin Li, William Rooney, Wei Huang, Brendan Moloney, Eric Baker
  • Patent number: 11719655
    Abstract: A method for measuring oil-water distribution using DNP-MRI, comprising adding a free radical for DNP enhanced NMR signal of a water phase or an oil phase in a sample containing oil and water; performing an MRI experiment on the sample, and collecting an MRI image of the sample without DNP enhancement; applying microwave excitation for DNP-MRI experiment under the same MRI experiment condition as step 2, and collecting an MRI image of the sample after DNP enhancement; and comparing the MRI image after DNP enhancement with the MRI image without DNP enhancement. In the MRI image with DNP enhancement, an area with enhanced MRI signal intensity is a selectively enhanced fluid phase distribution area, and an area without obviously changed MRI signal intensity is a non-selectively enhanced fluid phase distribution area. The method is simple, convenient to operate, short in measurement time, and high in measurement efficiency.
    Type: Grant
    Filed: November 5, 2021
    Date of Patent: August 8, 2023
    Assignee: Innovation Academy For Precision Measurement Science And Technology, Chinese Academy of Sciences
    Inventors: Li Chen, Junfei Chen, Chaoyang Liu, Zhen Zhang, Tao Feng, Jiwen Feng, Fang Chen
  • Patent number: 11698373
    Abstract: Apparatus and methods for the detection of proteins in biological fluids such as urine using a label-free assay is described. Specific proteins are detected by their binding to highly specific capture reagents such as SOMAmers that are attached to the surface of a substrate. Changes to these capture reagents and their local environment upon protein binding modify the behavior of color centers (e.g., fluorescence, ionization state, spin state, etc.) embedded in the substrate beneath the bound capture reagents. These changes can be read out, for example, optically or electrically, for an individual color center or as an average response of many color centers.
    Type: Grant
    Filed: February 15, 2022
    Date of Patent: July 11, 2023
    Assignee: SomaLogic Operating Co., Inc.
    Inventors: Jason Paul Cleveland, Karoly Holczer, Barry Patrick John Vant-Hull
  • Patent number: 11694373
    Abstract: Methods for reconstructing images from undersampled k-space data using a machine learning approach to learn non-linear mapping functions from acquired k-space lines to generate unacquired target points across multiple coils are described.
    Type: Grant
    Filed: March 14, 2018
    Date of Patent: July 4, 2023
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Mehmet Akcakaya, Steen Moeller
  • Patent number: 11624797
    Abstract: A system and method for correcting phase shift in echo images are provided. The method may include one or more of the following operations. A plurality of echo images may be obtained. Homogeneous pixels in the plurality of echo images may be identified. A vector corresponding to each of at least some of the identified homogeneous pixels may be determined. A vector of a homogenous pixel includes a phase element and an amplitude element. A first complex linear model of phase shift may be determined based at least in part on the determined vectors. Phase shift of at least one of the plurality of echo images may be corrected based on the first complex linear model.
    Type: Grant
    Filed: February 21, 2021
    Date of Patent: April 11, 2023
    Assignee: SHANGHAI UNITED IMAGING HEALTHCARE CO., LTD.
    Inventors: Yanen Guo, Zhongqi Zhang
  • Patent number: 11609289
    Abstract: In a method for providing setting parameter sets for at least one measuring protocol described by protocol parameters for acquiring magnetic resonance data with a magnetic resonance facility, setting parameter set is determined for each of at least two temperature status categories of the magnetic resonance facility using a temperature model describing a development of a temperature status of at least one component of the magnetic resonance facility. The method also includes preventing overheating of the at least one component due to the measurement with the measuring protocol being repeated a maximum number of times for a specified number of repetitions.
    Type: Grant
    Filed: September 24, 2020
    Date of Patent: March 21, 2023
    Assignee: Siemens Healthcare GmbH
    Inventors: Thorsten Feiweier, Michael Köhler
  • Patent number: 11586966
    Abstract: Techniques regarding the development and/or analysis of one or more quantum computing programs are provided. For example, one or more embodiments described herein can comprise a system, which can comprise a memory that can store computer executable components. The system can also comprise a processor, operably coupled to the memory, and that can execute the computer executable components stored in the memory. The computer executable components can comprise a circuit component, operatively coupled to the processor, that can create a quantum computing program over a period of time. The computer executable components can also comprise a visualization component, operatively coupled to the processor, that can generates a quantum state visualization that depicts a characterization of the quantum computing program over the period of time.
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: February 21, 2023
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Sanjana Arun Sharma, Anna Obikane, Francisco José Cabrera Hernández, Jay M. Gambetta
  • Patent number: 11585881
    Abstract: In vivo methods for non-invasively imaging (or measuring without spatial localization) of neuro-electro-magnetic oscillations are achieved by a pulse sequence of radio frequency (RF) irradiation and magnetic field gradients. These RF and gradient pulses create an intermolecular zero-quantum coherence (iZQC), the frequency of which is: 1) controlled by one or more magnetic field gradients; and 2) made to match the frequency of the targeted neuro-electro-magnetic oscillation.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: February 21, 2023
    Assignee: VANDERBILT UNIVERSITY
    Inventor: Daniel Gochberg
  • Patent number: 11573282
    Abstract: Techniques for compensating magnetic resonance imaging (MRI) data for artefacts caused by motion of a subject being imaged. The techniques include obtaining spatial frequency data obtained by using a magnetic resonance imaging (MRI) system to perform MRI on a patient, the spatial frequency data including first spatial frequency data and second spatial frequency data; determining a transformation using a first image obtained using the first spatial frequency data and a second image obtained using the second spatial frequency data; determining a residual spatial phase; correcting, using the transformation, second spatial frequency data and the residual spatial phase, to obtain corrected second spatial frequency data and a corrected residual spatial phase; and generating a magnetic resonance (MR) image using the corrected second spatial frequency data and the corrected residual spatial phase.
    Type: Grant
    Filed: October 23, 2020
    Date of Patent: February 7, 2023
    Assignee: Hyperfine Operations, Inc.
    Inventor: Carole Lazarus
  • Patent number: 11562282
    Abstract: In methods for simulating the evolution of a real-world quantum system over time, a state-preparation sequence of quantum gates is applied to a qubit register of a quantum computer. The state-preparation sequence is configured to prepare in the qubit register an initial model state representing an initial state of the real-world quantum system. A Hamiltonian operator for the real-world quantum system is received and used in the example method. The Hamiltonian operator represents two-body potential-energy interactions in a factorized form comprising at least one Majorana operator. A time-evolution-operator sequence of quantum gates comprising a block-encoded form of the Hamiltonian operator is now applied to the qubit register of the quantum computer, yielding a changed model state that represents a time-evolved state of the real-world quantum system. A measurement operation is applied subsequently to the qubit register.
    Type: Grant
    Filed: March 5, 2020
    Date of Patent: January 24, 2023
    Assignee: Microsoft Technology Licensing, LLC
    Inventor: Guang Hao Low
  • Patent number: 11554269
    Abstract: A method, apparatus and components thereof enable selective or differentiated manipulation of at least one of a plurality of particles located in a region of space via magnetic field generation and variation.
    Type: Grant
    Filed: January 31, 2020
    Date of Patent: January 17, 2023
    Assignee: WEINBERG MEDICAL PHYSICS, INC.
    Inventors: Irving Weinberg, Bradley English
  • Patent number: 11525880
    Abstract: Disclosed is a method for generating a time-dependent magnetic field gradient in diffusion weighted magnetic resonance imaging G(t)=[Gx(t)Gy(t)Gz(t)]T, which is asymmetric in time with respect to a refocusing pulse, by meeting one or more of the requirements: A=?0TEh(t)G(t)G(t)Tdt is zero, where TE is an echo time and h(t) is a function of time which is positive during an interval prior to the refocusing pulse and negative during a time interval after the refocusing pulse); minimize A or m=(Tr[AA])1/2 where A=?P1G(t)G(t)Tdt??P2G(t)G(t)Tdt where P1 and P2 represent time intervals prior to and subsequent to the refocusing pulse; m is smaller than a threshold value. an attenuation factor AF p = exp ? ( - t T ? 2 * ) due to T2* relaxation is one. Signal attenuation due to concomitant field gradients, regardless of the shape or orientation of the diffusion encoding b-tensor and the location of signal is hereby minimized.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: December 13, 2022
    Assignee: RANDOM WALK IMAGING AB
    Inventors: Filip Szczepankiewicz, Markus Nilsson
  • Patent number: 11519989
    Abstract: Devices for determining a state of a magnetic field-generating article are provided. In various embodiments, a device comprises: a single crystal diamond having a plurality of NV centers, the single crystal diamond configured to be disposed adjacent to a magnetic field-generating article, and configured to generate a fluorescent signal in response to being illuminated by a light source; a coherent light source configured to generate a light beam directed at the single crystal diamond; a microwave (MW) radiation source configured to irradiate the single crystal diamond with a MW signal; a magnetic field source configured to apply a bias magnetic field to the single crystal diamond; a photosensor configured to collect the fluorescent signal generated by the single crystal diamond; and a computing node operatively coupled to each of the coherent light source, the MW radiation source, the magnetic field source, and the photosensor.
    Type: Grant
    Filed: January 31, 2021
    Date of Patent: December 6, 2022
    Assignees: The MITRE Corporation, President and Fellows of Harvard College
    Inventors: Matthew James Turner, Edlyn Victoria Levine, Pauli Kehayias, Daniel T. Walters, Ronald L. Walsworth, Marko Loncar, Nicholas Ryan Langellier
  • Patent number: 11493576
    Abstract: The present disclosure relates to techniques for the selection of one or more measuring coils in magnetic resonance imaging. Herein, account can be taken of a preselection in the selection of the one or more measuring coils from a plurality of candidate coils.
    Type: Grant
    Filed: October 25, 2019
    Date of Patent: November 8, 2022
    Assignee: Siemens Healthcare GmbH
    Inventors: Stefan Meyer, Manuela Rick
  • Patent number: 11493584
    Abstract: In a method (100 to 208) in which hyperpolarizable tracer molecules (20, 88 to 98) are hydrogenated and then optionally also hyperpolarized for magnetic resonance imaging, it is provided that, in a first method step (104, 202), a hydrogen solution (10, 12, 4) having a saturation factor of at least 50% be prepared and that the hydrogenation reaction (186 to 190, 206) not be triggered until a subsequent, second method step (106, 204). An apparatus (1) with which the method of the invention (100 to 208) is executable is also provided.
    Type: Grant
    Filed: August 14, 2019
    Date of Patent: November 8, 2022
    Assignee: ALBERT-LUDWIGS-UNIVERSITAT FREIBURG
    Inventors: Andreas Schmidt, Jan-Bernd Hovener, Jurgen Hennig, Stephan Berner
  • Patent number: 11486948
    Abstract: The present invention relates to a method of calculating a proton density fat fraction, PDFF, from a water and fat separated magnetic resonance imaging, MRI, based on fat-referenced lipid quantification in a region of interest (ROI) and using determination of a reference tissue. The method comprises the step of determining: F·?f/R, wherein F is the fat signal in the ROI provided from the MRI, ?f is a function providing a ratio between T1 saturation values of the fat signals in the reference tissue and in the ROI; and R is a representation of the sum of fat and water signals on an intensity scale where the saturation of each of the fat and water signals equals the saturation of fat in the reference tissue.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: November 1, 2022
    Assignee: AMRA MEDICAL AB
    Inventor: Olof Dahlqvist Leinhard
  • Patent number: 11486951
    Abstract: In MRI, upon simultaneously generating computed images of multiple parameters, imaging time is efficiently reduced while preventing decrease in spatial resolution and SN ratio as much as possible. A plurality of original images is reconstructed from nuclear magnetic resonance signals acquired under various imaging conditions, and a computed image is obtained by calculation performed among the plurality of original images. The various imaging conditions include an imaging condition that a repetition time of an imaging sequence is different from one another, and upon imaging, the number of phase encoding steps is made smaller when the repetition time is long. An image is reconstructed in such a manner that a matrix size of the image obtained when the number of phase encoding steps is small is made equal to the matrix size of the image obtained when the number of phase encoding steps is large.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: November 1, 2022
    Assignee: FUJIFILM HEALTHCARE CORPORATION
    Inventors: Yo Taniguchi, Hisaaki Ochi, Tomoki Amemiya, Toru Shirai
  • Patent number: 11486946
    Abstract: A sample chamber holder for MAS-NMR capable of operating at both low and high pressures. In one example the sample chamber holder is made up of a sample holder body defining a sample chamber therein, a connector configured to operatively statically hold an in situ rotor within the sample chamber; a coupler configured to operatively connect the sampler holder body to a magnetically coupled rotation member. The magnetically coupled rotation member is configured to engage and rotate a sealing cap from an NMR rotor in such a way so as to allow an NMR cap to be alternatively opened or sealed in-situ while the NMR rotor remains statically positioned in an NMR device.
    Type: Grant
    Filed: October 16, 2020
    Date of Patent: November 1, 2022
    Assignee: BATTELLE MEMORIAL INSTITUTE
    Inventors: Jian Z. Hu, Nicholas R. Jaegers, Mark R. Townsend, Mary Y. Hu
  • Patent number: 11474178
    Abstract: A method for generating a magnetic resonance image includes providing MR segment data records, wherein each MR segment data record has N×M frequency voxels in k-space. To reduce the acquisition time during MR segment recordings, the amount of MR data is reduced by incompletely sampling the k-space during a recording. The missing data of the MR segment data records are reconstructed twice: Preliminarily reconstructed MR segment data records are calculated first, with a reconstruction kernel obtained from reference data. Modified reference images containing phase information are obtained by creating phase images from the preliminarily reconstructed MR segment data records and combining these phase images with the absolute value of the reference image generated from the reference data. The second reconstruction kernels are ascertained therefrom in turn. In contrast to the first reconstruction kernel, these contain phase information, such that the missing data can be reconstructed without phase artifacts.
    Type: Grant
    Filed: February 24, 2021
    Date of Patent: October 18, 2022
    Assignee: BRUKER BIOSPIN MRI GMBH
    Inventor: Michael Herbst
  • Patent number: 11474181
    Abstract: The present disclosure discloses a magnetic resonance imaging method based on a blade sequence. The method can include acquiring 3-D data collected by a surface coil, determining a corresponding plurality of kernel data of each blade from the 3-D data according to the position information of each blade, collecting a corresponding plurality of slices of aliasing K-space data of each blade, performing convolution operations for the corresponding plurality of slices of aliasing K-space data of each blade and the corresponding plurality of kernel data of each blade to obtain a corresponding plurality of unaliasing K-space data of each blade, and reconstructing images for the corresponding plurality of unaliasing K-space data of different blades to obtain a plurality of unaliasing images. The present disclosure further describes a magnetic resonance imaging device for realizing the method and a computer-readable storage medium.
    Type: Grant
    Filed: November 13, 2019
    Date of Patent: October 18, 2022
    Assignee: Siemens Healthcare GmbH
    Inventors: Kun Zhou, Wei Liu