Using An Electron Resonance Spectrometer System Patents (Class 324/316)
  • Patent number: 8836331
    Abstract: The major object of the invention is to provide a volume-type hologram resin composition and a surface relief-type hologram resin composition having a high effect of preventing forgery and excellent in foil cutting, as well as a hologram layer and a hologram transfer foil using thereof. To achieve the object, there is provided a volume-type hologram resin composition having at least one kind of photopolymerizable compound, a photopolymerization initiator and fine particles, wherein the fine particles show magnetic resonance.
    Type: Grant
    Filed: August 15, 2011
    Date of Patent: September 16, 2014
    Assignee: Dai Nippon Printing Co., Ltd.
    Inventors: Hiroyuki Otaki, Kenji Ueda
  • Patent number: 8816685
    Abstract: A method and system for performing pulsed electron paramagnetic resonance is disclosed. In one aspect, the method includes generating an excitation pulse train for applying to an object having probes and detecting from the probes an echo response induced by the excitation pulse train.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: August 26, 2014
    Assignees: IMEC, Pepric nv
    Inventors: Peter Vaes, Stephanie Teughels
  • Publication number: 20140218032
    Abstract: In some aspects, a resonator device for spin resonance applications is described. In some examples, the resonator device includes a substrate, terminals, and resonators. The terminals include a first terminal having first terminal segments disposed on a substrate surface, and a second terminal having second terminal segments disposed on the substrate surface opposite the first terminal segments. The resonators include conductors disposed on the substrate surface between the first and second terminals. Each conductor is disposed between one of the first terminal segments and a respective, opposite one of the second terminal segments.
    Type: Application
    Filed: June 28, 2013
    Publication date: August 7, 2014
    Applicant: Quantum Valley Investment Fund LP
    Inventors: Hamidreza Mohebbi, David G. Cory
  • Patent number: 8798949
    Abstract: A spectrometer has: Accumulation means to obtain a data set containing N data points, repeating the measurement M times to obtain M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN), and accumulating the M spectral data sets or time-domain data sets. Means for creating sets S1 (dn) to SM (dn) of the data points contained in the M spectral data sets or time-domain data sets S1 (d1 to dN) to SM (d1 to dN). Correlation computing means for finding correlations. Computing means for finding either the product of an accumulated or anticipated spectrum.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: August 5, 2014
    Assignee: JEOL Resonance Inc.
    Inventors: Kiyonori Takegoshi, Yusuke Nishiyama
  • Publication number: 20140210473
    Abstract: An electron spin resonance spectrometer includes a bridge to transmit an excitation frequency and to receive a signal frequency; a probe electrically connected to the bridge and comprising: a first conductor in electrical communication with the bridge to transmit the signal frequency to the bridge; a shorting member electrically connected to the first conductor to transmit the excitation frequency to a sample, to produce the signal frequency, and to transmit the signal frequency to the first conductor; and a second conductor electrically connected to the shorting member; and a magnet disposed proximate to the probe.
    Type: Application
    Filed: April 3, 2014
    Publication date: July 31, 2014
    Applicant: NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
    Inventors: JASON P. CAMPBELL, KIN P. CHEUNG, JASON T. RYAN, PATRICK M. LENAHAN
  • Publication number: 20140167754
    Abstract: Apparatus, methods, and other embodiments associated with nuclear magnetic resonance (NMR) fingerprinting using echo splitting are described. One example apparatus includes an NMR logic configured to repetitively and variably sample a (k, t, E) space associated with an object to acquire a set of NMR signals. Members of the set of NMR signals are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The varying parameters may include the number of echo splitting pulses, spacings between echo splitting pulses, flip angle of echo splitting pulses, echo time, RF amplitude, and other parameters. The NMR apparatus may also include a signal logic configured to produce an NMR signal evolution from the NMR signals, and a characterization logic configured to characterize a resonant species in the object as a result of comparing acquired signals to reference signals.
    Type: Application
    Filed: September 12, 2013
    Publication date: June 19, 2014
    Applicant: Case Western Reserve University
    Inventors: Renate Jerecic, Mark Griswold, Yun Jiang, Dan Ma
  • Patent number: 8717025
    Abstract: In a method and system for echo planar imaging, after having applied a radiofrequency pulse and a slice selection gradient, continuous readout gradients alternating between positive and negative are applied and a phase encoding gradient is applied before starting each readout gradient. A slice selection gradient is applied at the same time as applying the phase encoding gradient. Scanning signals are collected during the duration of the readout gradients. Image reconstruction is implemented based on the scanning signals to obtain a scanned image.
    Type: Grant
    Filed: October 20, 2010
    Date of Patent: May 6, 2014
    Assignee: Siemens Aktiengesellschaft
    Inventor: De He Weng
  • Publication number: 20140097842
    Abstract: A method includes generating, from an integrated oscillator circuit, an oscillating output signal and generating, by an integrated power amplifier (PA) circuit, an amplified oscillating output signal based on the oscillating output signal. The method further includes receiving, by integrated receiver amplifier circuit, an electron spin resonance (ESR) signal from biological samples that include a magnetic species and generating, by the integrated receiver amplifier circuit, an amplified ESR signal based on the received ESR signal. The method further includes receiving, by the integrated receiver amplifier circuit, an electron spin resonance (ESR) signal from magnetic nanoparticles that are loaded with drugs or attached to human cells.
    Type: Application
    Filed: September 30, 2013
    Publication date: April 10, 2014
    Applicant: William Marsh Rice University
    Inventors: Xuebei Yang, Charles Chen, Payam Seifi, Aydin Babakhani
  • Publication number: 20140097841
    Abstract: Systems and methods for spinwave-based metrology in accordance with embodiments of the disclosure involve generating and detecting spinwaves in a sample having a ferromagnetic material; and determining a material thickness, a material integrity measure, a presence of a manufacturing defect, a categorical type of manufacturing defect, and/or a manufacturing process statistic corresponding to spinwave behavior in the sample. In an embodiment, spinwaves are generated by way of concurrent exposure of a target measurement site of the sample to each of a bias magnetic field and radiation (e.g., microwave or radio frequency radiation) produced by a first set of integrated waveguides. A response signal corresponding to a behavior of spinwaves within the target measurement site can be generated by way of a second set of integrated waveguides.
    Type: Application
    Filed: September 6, 2013
    Publication date: April 10, 2014
    Applicant: NATIONAL UNIVERSITY OF SINGAPORE
    Inventors: Hyunsoo YANG, Sankha Subhra MUKHERJEE, Jae Hyun KWON
  • Patent number: 8674694
    Abstract: An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of fingernails, toenails, and/or teeth. A coil structure allows in vivo measurement of tooth enamel or fingernail keratin with reduced coupling to underlying tissue.
    Type: Grant
    Filed: August 25, 2010
    Date of Patent: March 18, 2014
    Inventors: James S. Hyde, Jason W. Sidabras, Richard R. Mett
  • Patent number: 8664955
    Abstract: The present invention provides an apparatus and a corresponding method useful for electron paramagnetic resonance imaging, in situ and in vivo, using high-isolation transmit/receive (TX/RX) coils, which, in some embodiments, provide microenvironmental images that are representative of particular internal structures in the human body and spatially resolved images of tissue/cell protein signals responding to conditions (such as hypoxia) that show the temporal sequence of certain biological processes, and, in some embodiments, that distinguish malignant tissue from healthy tissue. In some embodiments, the TX/RX coils are in a surface, volume or surface-volume configuration.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: March 4, 2014
    Inventor: Howard J. Halpern
  • Patent number: 8653819
    Abstract: A method, system, apparatus, and computer readable medium has been provided with the ability to obtain a complex permittivity ? or a complex permeability ? of a sample in a cavity. One or more complex-valued resonance frequencies (fm) of the cavity, wherein each fm is a measurement, are obtained. Maxwell's equations are solved exactly for ?, and/or ?, using the fm as known quantities, thereby obtaining the ? and/or ? of the sample.
    Type: Grant
    Filed: September 2, 2010
    Date of Patent: February 18, 2014
    Assignee: California Institute of Technology
    Inventors: Martin B. Barmatz, Henry W. Jackson
  • Patent number: 8648596
    Abstract: Described is an electron spin resonance (ESR) spectrometer comprising a miniaturized radio-frequency (RF) microwave cavity resonator. The miniaturized RF microwave cavity resonator receives a carrier signal from a circulator, modulates the signal path signal, and reflects the carrier signal back to the circulator to amplify the carrier signal prior to demodulation. A mixer receives and demodulates the carrier signal and outputs an audio signal to generate an ESR spectrum for analyzing a chemical composition of a fluid sample. The ESR spectrum represents a magnetic susceptibility of the fluid sample to a magnetic resonance cause variation in a resonant frequency of the miniaturized RF microwave cavity resonator. In a desired aspect, the carrier signal is split into two paths prior to demodulation. The two paths are demodulated by different mixers to produce two separate outputs, an absorption spectrum and a dispersion spectrum.
    Type: Grant
    Filed: October 18, 2010
    Date of Patent: February 11, 2014
    Assignee: Active Spectrum, Inc.
    Inventors: Colin T. Elliott, Christopher John White, James R. White
  • Patent number: 8643362
    Abstract: According to one embodiment, a apparatus includes a coil, a clock generator, an echo transmitter, a carrier generator, a clock transmitter, a regenerator, an receiver, a reconstructor, a detector, and a controller. The echo transmitter generates and transmits an echo transmission signal synchronously with a clock signal generated by the clock generator to wirelessly transmit an echo signal output from the col. The carrier generator generates a carrier signal have a frequency within a variable range. The clock transmitter wirelessly transmits a clock transmission signal. The regenerator regenerates the clock signal based on the transmitted clock transmission signal. The receiver extracts the echo signal synchronously with the regenerated clock signal from the transmitted echo transmission signal. The detector detects a frequency of an interference wave.
    Type: Grant
    Filed: March 15, 2011
    Date of Patent: February 4, 2014
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Takahiro Sekiguchi, Koji Akita, Toshiyuki Nakanishi, Kazuya Okamoto, Sojuro Kato
  • Publication number: 20140021952
    Abstract: A microwave resonator device (1), being configured in particular for electron spin resonance measurements, comprises a resonator being resonant with first and second microwave field modes and including first and second resonance sections (7, 8) arranged along a longitudinal axis (2) of the resonator, and a coupling unit being arranged between the first and second resonance sections, wherein the coupling unit includes a conducting plate (16) being arranged on the longitudinal axis (2) and covering a central portion of a cross-sectional area of the resonator, the conducting plate (16) is adapted to adjust a first mode frequency of the first microwave field mode, and the conducting plate (16) is arranged at a field minimum of the second microwave field mode. Furthermore, a method of conducting an electron spin resonance measurement with a sample to be investigated is described.
    Type: Application
    Filed: July 27, 2010
    Publication date: January 23, 2014
    Applicant: Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.
    Inventors: Igor Tkach, Marina Bennati
  • Publication number: 20140009159
    Abstract: A system and method involve performing electron paramagnetic resonance on an object under study. The system comprises a first field generator adapted for generating an orienting magnetic field for orienting the magnetization of the object under study and a second field generator adapted for generating RF excitation waves at a frequency to generate electron paramagnetic resonance (EPR) in the object under test. The system also comprises a detection unit adapted for detecting the EPR signals emitted by the object under test and a control unit adapted for controlling the relative orientation of the orienting magnetic field induced by the first field generator with respect to the detection unit. The system furthermore comprises a processing unit programmed for combining detected EPR signals obtained using different relative orientations of the orienting magnetic field with respect to the detection unit.
    Type: Application
    Filed: March 21, 2012
    Publication date: January 9, 2014
    Applicant: PEPRIC NV
    Inventors: Peter Vaes, Stephanie Teughels
  • Patent number: 8610434
    Abstract: In an electron paramagnetic resonance spectrometer, a closed cycle cryocooler is used to cool gaseous helium, which is then circulated around a sample to cool the sample by direct convection. Since the sample is not mechanically connected to the refrigerator, no vibrations are transmitted from the refrigerator to the sample and the sample can be quickly removed and replaced. The cooled helium can be passed through a Joule-Thomson expansion device before circulating the cooled helium around the sample to further cool the helium. In addition, a vacuum pump can be connected to the helium outlet after circulating the cooled helium around the sample to increase the pressure differential across the Joule-Thomson expansion device and further cool the helium. In order to raise the temperature of the cooled helium, a heater can be placed about the cooled helium line upstream from the sample.
    Type: Grant
    Filed: July 21, 2011
    Date of Patent: December 17, 2013
    Assignee: Coldedge Technologies, Inc.
    Inventors: Arthur H. Heiss, Ajay Khatri
  • Publication number: 20130285661
    Abstract: The invention relates to a spin detector arrangement for detecting vector components of a predominating spin vector in a particle beam (T) having a predominating spin orientation of the particles. The spin detector arrangement comprises a spin rotator (1) having a switchable coil (5), wherein the switchable coil (5) comprises an axial direction and is aligned such that the particle beam (T) passes through the switchable coil (5) along the axial direction; a deflection device (7) connected downstream of the spin rotator (1) and deflecting the path of the particle beam (T) electrostatically by a deflection angle; a spin detector (9) connected downstream of the deflection device (7), allowing the deflection of the vector component of the spin vector predominating in the particle beam (T) perpendicular to the direction of motion of the particle beam (T); and a switching unit (15) connected to the switchable coil (5), allowing switching of the excitation state of the coil (5).
    Type: Application
    Filed: November 16, 2011
    Publication date: October 31, 2013
    Applicant: SPECS SURFACE NANO ANALYSIS GMBH
    Inventor: Oliver Schaff
  • Patent number: 8564293
    Abstract: The invention relates to a method for changing spin relaxation, a method for detecting a spin current, and a spintronic device using spin relaxation, and spin relaxation is changed through injection of a spin current. A spin current 4 is injected into a material 1 in a certain spin state, so that the spin relaxation time can be controlled.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: October 22, 2013
    Assignee: Tohoku University
    Inventors: Kazuya Ando, Kazuya Harii, Kohei Sasage, Eiji Saitoh
  • Publication number: 20130271140
    Abstract: Example apparatus and methods order projections in a 3D MRI acquisition to achieve improved equidistant spacing or to achieve improved adherence to a target distribution. The equidistant or target spacing may exist in k-space and/or in kt-space. In one embodiment, the improved equidistant spacing is a substantially uniform spacing. The substantially uniform spacing may be achieved using a modification of a charge repulsion analysis that treats points of projections that intersect the surface of a 3D volume to be imaged as point charges distributed on the 3D volume. In another embodiment, the target spacing may be uniform, non-uniform, uniform in parts and non-uniform in other parts, and other combinations.
    Type: Application
    Filed: April 13, 2012
    Publication date: October 17, 2013
    Applicant: Case Western Reserve University
    Inventors: Mark Griswold, Gregory R. Lee
  • Patent number: 8552724
    Abstract: A method for spin magnetic resonance applications in general, and for performing NMR (nuclear magnetic resonance spectroscopy) and MRI (nuclear magnetic resonance imaging) in particular is disclosed. It is a quantum theory-based continuous precision method. This method directly makes use of spin magnetic resonance random emissions to generate its auto-correlation function and power spectrum, from which are derived spin relaxation times and spin number density using strict mathematical and physical equations. This method substantially reduces the NMR/MRI equipment and data processing complexity, thereby making NMR/MRI machines less costly, less bulky, more accurate, and easier to operate than the pulsed NMR/MRI. By employing extremely low transverse RF magnetic B1 field, MRI with this method is much safer for patients. And, by employing continuous spin magnetic resonance emissions, NMR with this method is of virtually unlimited spectral resolution to satisfy any science and engineering requirements.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: October 8, 2013
    Inventor: Derek D. Feng
  • Publication number: 20130257431
    Abstract: Various systems and methods for detecting electron spins using electron paramagnetic resonance are described. An excitation signal generator configured to generate an excitation signal of varying amplitude and phase as compared to a reference signal may be present. A crossed-loop resonator configured to isolate a detection signal produced by the excitation signal exciting an object with a magnetic field may also be present. Further, a detection device configured to detect electron spins of the object using the detection signal isolated by the crossed-loop resonator may be present.
    Type: Application
    Filed: March 7, 2013
    Publication date: October 3, 2013
    Inventor: Colorado Seminary, which owns and operates the University of Denver
  • Patent number: 8542014
    Abstract: A method and system are disclosed for gathering information about an object including single domain particles which have a diameter in the range of about 5 to 80 nm. In one aspect, a method includes generating a static magnetic field of less than about 0.1 Tesla on the object and generating an RF energy, pulsed or continuous wave, so as to generate electron paramagnetic resonance of the single domain particles. The method also includes detecting the electron paramagnetic resonance of the single domain particles in the form of an image of the object. The single domain particles may have a predetermined diameter and a predetermined saturation magnetization and the applied magnetic field may be such that the single domain particles reach a magnetization being at least about 10% of the saturation magnetization. The method may be used for detecting tags in an object and for activating tags.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: September 24, 2013
    Assignee: IMEC
    Inventors: Stephanie Teughels, Peter Vaes
  • Patent number: 8525516
    Abstract: This atomic clock comprises means for applying two mutually perpendicular oscillating magnetic fields (9, 10), governed by a control device (5) that makes them apply a static or nearly static magnetic field for compensating the ambient magnetic field in order to cancel sub-level energy variations of the matter, which disrupt the frequency of the returned photons and the reference provided by the clock. Traditional magnetic shielding may be omitted. Said device can also operate as a magnetometer.
    Type: Grant
    Filed: December 10, 2008
    Date of Patent: September 3, 2013
    Assignee: Commissariat à l'énergie atomique et aux énergies alternatives
    Inventors: Matthieu Le Prado, Jean-Michel Leger
  • Patent number: 8508229
    Abstract: A magnetic resonance elastography (“MRE”) driver that can produce shear waves in a subject without relying on mode conversion of longitudinal waves is disclosed. More specifically, the MRE driver includes a pneumatic driver located remotely from a magnetic resonance imaging (“MRI”) system which is operable in response to an applied electrical current to oscillate, a pressure-activated driver that is positioned on a subject in the MRI system, and a tube that is in fluid communication, at one end, with the pneumatic driver. The pressure-activated driver includes a base plate and a driver plate having a region between them that receives the tube. Oscillations of the pneumatic driver produce a pressure wave in the tube that causes the driver plate to vibrate. The driver plate rests against the subject of interest to apply a corresponding shear oscillatory force to the subject during the MRE examination.
    Type: Grant
    Filed: July 30, 2010
    Date of Patent: August 13, 2013
    Assignee: MAYO Foundation for Medical Education and Research
    Inventors: Eric C Ehman, Kiaran P McGee, Richard L Ehman
  • Publication number: 20130127466
    Abstract: A scanner for assessing localized oxygenation of a desired region of interest includes a handheld housing having a proximal end and a distal end. A resonator coil is disposed within the housing and also disposed adjacent the distal end of the housing. The resonator coil is configured to both excite and read paramagnetic materials. A magnet is disposed within the housing and also disposed adjacent the distal end of the housing. The magnet is configured to provide a substantially uniform magnetic field over the desired region of interest. The scanner is configured to use electron paramagnetic resonance to assess localized oxygenation in the desired region.
    Type: Application
    Filed: May 25, 2012
    Publication date: May 23, 2013
    Applicant: 02 Insights, Inc.
    Inventors: Periannan Kuppusamy, Samit Kumar Gupta, Robert Lawrence Rushenberg
  • Publication number: 20130119986
    Abstract: The invention relates to a method for acquiring, by use of a continuous-wave electron spin resonance imaging scheme that sweeps a magnetic field, a 14N nitroxy radical distribution image and a 15N nitroxy radical distribution image in a single image capturing operation. This image acquiring method is characterized in that the central one (B) of three absorption peaks derived from 14N nitroxy radical is caused to move to a higher or lower magnetic field side and Fourier transform is used to determine a parameter (?), which represents the amplitude of the absorption peak of the higher or lower magnetic field side, and a parameter (?) which represents the peak position of that absorption peak.
    Type: Application
    Filed: July 26, 2011
    Publication date: May 16, 2013
    Applicant: NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventor: Hiroshi Hirata
  • Publication number: 20130093424
    Abstract: A resonator system for electron spin resonance (ESR) is disclosed. The resonator system comprises: a generally planar resonator layer defining an open-loop gapped by a non-conductive gap in the layer, and a microwave feed, positioned configured for transmitting microwave to the resonator layer such as to concentrate, with a quality factor of at least 100, a magnetic field within an effective volume of less than 1 nL above the layer.
    Type: Application
    Filed: October 18, 2011
    Publication date: April 18, 2013
    Inventors: Aharon BLANK, Ygal TWIG
  • Patent number: 8421460
    Abstract: An upconverter has a two port parametric amplifier that has a first port to receive an input signal to be amplified and upconverted and a second port to receive a local oscillator signal and to output the amplified, upconverted signal at upper and lower sideband frequencies. The upconverter further has an antenna coupled to the second port to receive the local oscillator signal and transmit the amplified, upconverted signal at upper and lower sideband frequencies and a low noise amplifier at the first port of the parametric amplifier, which is powered by the local oscillator signal.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: April 16, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventor: Anthony Peter Hulbert
  • Patent number: 8421461
    Abstract: A magnetic resonance imaging system upconverter stage has a number of local coils and a number of upconverters to receive a signal from an output of each coil. Each upconverter has a number of two port upconverter cores, each core having a first port to receive a signal from a local coil and a second port to output an upconverted signal at upper and lower sideband frequencies through an antenna coupled to the second port. The inputs of the plurality of upconverter cores are connected in parallel, and at least one antenna is associated with the second port of each core.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: April 16, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventors: Peter Cork, Anthony Peter Hulbert
  • Patent number: 8415951
    Abstract: An upconverter has a two port parametric amplifier that has a first port to receive an input signal to be amplified and upconverted and a second port to receive a local oscillator signal and to output the amplified, upconverted signal at upper and lower sideband frequencies. The upconverter further has an antenna coupled to the second port and a power splitter inserted between the second port of the parametric amplifier and the antenna.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: April 9, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventor: Markus Vester
  • Patent number: 8410778
    Abstract: In a magnetic resonance (MR) method and apparatus for the acquisition of a first image data set and a second image data set of an examination subject, a series of excitation pulses is radiated into the examination subject, and after each excitation pulse, a first echo signal is detected after a first echo time TE1 and a second echo signal is detected after a second echo time TE2, with TE2 greater than TE1, and the first echo signal is entered in a first raw MR data set and the second echo signal is entered in a second raw MR data set. A first image data set is acquired from the first MR data set on the basis of magnitude information contained in the first MR data set. A second image data set is acquired from the second MR data set on the basis of phase information contained in the second MR data set. The first and second image data sets are stored on at least one memory device.
    Type: Grant
    Filed: March 12, 2010
    Date of Patent: April 2, 2013
    Assignee: Siemens Aktiengesellschaft
    Inventors: Patrick Gross, Joerg Roland
  • Patent number: 8410776
    Abstract: An emission tomography detector module and an emission tomography scanner are disclosed. In at least one embodiment, the emission tomography detector modules includes a scintillator to capture an photon, the scintillator emitting a scintillating light on capturing the photon; a first type of solid-state photodetector to detect the scintillating light; and a second type of solid-state photodetector to detect the scintillating light, wherein the first type of solid-state photodetector and the second type of solid-state photodetector are different with respect to a detecting property.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: April 2, 2013
    Assignees: Siemens Medical Solutions USA, Inc., Siemens Aktiengesellschaft
    Inventors: Matthias J. Schmand, Markus Vester, Nan Zhang
  • Publication number: 20130021032
    Abstract: In an electron paramagnetic resonance spectrometer, a closed cycle cryocooler is used to cool gaseous helium, which is then circulated around a sample to cool the sample by direct convection. Since the sample is not mechanically connected to the refrigerator, no vibrations are transmitted from the refrigerator to the sample and the sample can be quickly removed and replaced. The cooled helium can be passed through a Joule-Thomson expansion device before circulating the cooled helium around the sample to further cool the helium. In addition, a vacuum pump can be connected to the helium outlet after circulating the cooled helium around the sample to increase the pressure differential across the Joule-Thomson expansion device and further cool the helium. In order to raise the temperature of the cooled helium, a heater can be placed about the cooled helium line upstream from the sample.
    Type: Application
    Filed: July 21, 2011
    Publication date: January 24, 2013
    Applicant: COLDEDGE TECHNOLOGIES, INC.
    Inventors: Arthur H. HEISS, Ajay KHATRI
  • Publication number: 20130015857
    Abstract: A method and system are disclosed for gathering information about an object including single domain particles which have a diameter in the range of about 5 to 80 nm. In one aspect, a method includes generating a static magnetic field of less than about 0.1 Tesla on the object and generating an RF energy, pulsed or continuous wave, so as to generate electron paramagnetic resonance of the single domain particles. The method also includes detecting the electron paramagnetic resonance of the single domain particles in the form of an image of the object. The single domain particles may have a predetermined diameter and a predetermined saturation magnetization and the applied magnetic field may be such that the single domain particles reach a magnetization being at least about 10% of the saturation magnetization. The method may be used for detecting tags in an object and for activating tags.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 17, 2013
    Applicant: IMEC
    Inventors: Stephanie TEUGHELS, Peter Vaes
  • Publication number: 20120326722
    Abstract: Instrumentation and methodologies are provided that enable the direct measurement of free radicals generated in patients as a result of radiation therapy through the use of proton beams and other forms of ionizing radiation. As a result, in accordance with at least one disclosed embodiment, the instrumentation and methodologies may be used in conjunction with radiation therapy to detect, monitor and/or control generation of free radicals in cancerous tissue during such radiation therapy.
    Type: Application
    Filed: May 18, 2012
    Publication date: December 27, 2012
    Applicant: WEINBERG MEDICAL PHYSICS LLC
    Inventors: Irving N. WEINBERG, Stanley Thomas FRICKE
  • Patent number: 8334698
    Abstract: A sample holding device, adapted for holding a sample, like a rodent or an MR phantom sample in a magnet bore of a magnetic resonance tomography (MRT) device, comprises a sample carrier being adapted for an arrangement in the bore of the MRT device, wherein the sample carrier comprises a carrier platform for accommodating the sample and at least one clamping part with radial locking pieces being adapted for fixing the sample carrier in a hollow enclosure structure, wherein the at least one clamping part is connected with the carrier platform. Furthermore, an MRT device and a method of MRT imaging of a sample are described.
    Type: Grant
    Filed: August 1, 2007
    Date of Patent: December 18, 2012
    Assignees: Max-Planck-Gesellschaft zur Forderung der Wissenschaften e.V., Biomedizinische NMR Forschungs GmbH
    Inventors: Roland Tammer, Susann Boretius, Thomas Michaelis, Andreas Pucher-Diehl
  • Patent number: 8314740
    Abstract: A magnetic field focusing assembly includes a magnetic field generating device configured to generate a magnetic field, and a split ring resonator assembly configured to be magnetically coupled to the magnetic field generating device and configured to focus the magnetic field produced by the magnetic field generating device.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: November 20, 2012
    Assignee: DEKA Products Limited Partnership
    Inventor: David Blumberg, Jr.
  • Publication number: 20120262176
    Abstract: A method for determination of the images of electron relaxation times, T1, in EPR tomography consists in the resultant relaxation time, T1, established from the ratio of amplitudes of signals recorded for various scanning directions is found, whereupon a variability function of the resultant relaxation time, T1, is found for at least two different scan frequencies, whereupon projections for the respective relaxation times are established for every point of the recorded spectra by matching functions specific for the respective relaxation times to the resultant function of variability of relaxation time, and then images are reconstructed in 1D or in 2D or in 3D depend of the experimental conditions.
    Type: Application
    Filed: March 22, 2012
    Publication date: October 18, 2012
    Applicant: POLITECHNIKA POZNANSKA
    Inventors: Tomasz CZECHOWSKI, Mikolaj BARANOWSKI, Kazimierz JURGA, Jan JURGA, Wojciech CHLEWICKI, Piotr SZCZEPANIK, Piotr KEDZIA
  • Publication number: 20120265426
    Abstract: An instrument and method using electron spin resonance spectrometry for measuring the concentration of airborne soot particles, and the like, that includes continuously passing a sample of exhaust gas through a resonating RF microwave cavity resonator during the application therethrough of a uniform slowly varying uniform magnetic field that is rapidly modulated and measuring the resulting phase modulation or amplitude modulation thereof to derive an electron spin resonance signal that directly senses the concentration of carbon free radicals produced as a result of inefficient combustion of hydrocarbons during operation of the vehicle or boiler. A further invention is the use of this signal for feedback control of the engine or boiler operating parameters to minimize or substantially eliminate particulate matter emissions.
    Type: Application
    Filed: June 25, 2012
    Publication date: October 18, 2012
    Inventors: James Robert White, Christopher John White, Colin T. Elliott, Alexander H. Slocum
  • Patent number: 8283926
    Abstract: A method and system are disclosed for gathering information about an object including single domain particles which have a diameter in the range of about 5 to 80 nm. In one aspect, a method includes generating a static magnetic field of less than about 0.1 Tesla on the object and generating an RF energy, pulsed or continuous wave, so as to generate electron paramagnetic resonance of the single domain particles. The method also includes detecting the electron paramagnetic resonance of the single domain particles in the form of an image of the object. The single domain particles may have a predetermined diameter and a predetermined saturation magnetization and the applied magnetic field may be such that the single domain particles reach a magnetization being at least about 10% of the saturation magnetization. The method may be used for detecting tags in an object and for activating tags.
    Type: Grant
    Filed: December 2, 2010
    Date of Patent: October 9, 2012
    Assignee: IMEC
    Inventors: Stephanie Teughels, Peter Vaes
  • Patent number: 8269496
    Abstract: An electron paramagnetic resonance imaging system that includes means for continuously irradiating a sample with RF irradiation; means for imposing on the sample a sinusoidally varying magnetic field along with rotating gradients for spatial encoding; means for directly detecting signal data from the sample, without using field modulation, while irradiating the sample with RF radiation continuously, the means for directly detecting having means for sweeping the sinusoidally varying magnetic field; and means for processing the signal data, using means including a digital signal processor.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: September 18, 2012
    Assignee: The United States of America, as represented by the Secretary of the Department of Health and Human Services
    Inventors: Sankaran Subramanian, Nallathamby Devasahayam, Janusz Koscielniak, James B. Mitchell, Murali Krishna Cherukuri
  • Patent number: 8237441
    Abstract: A method and an apparatus are disclosed for determining the effective count rate of photons in a combined MR/emission tomography recording.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: August 7, 2012
    Assignee: Siemens Aktiengesellschaft
    Inventors: Axel Martinez-Möller, Stephan Nekolla
  • Patent number: 8217657
    Abstract: A diplex filter is formed by two impedance-transforming filters with separate transmission frequency ranges and with separate cut-off frequency ranges and a connection node at which two series elements of the two filters are connected. These two series elements are each fashioned as a parallel oscillating circuit, each parallel oscillating circuit exhibiting a predetermined reactance in a midband of the respective transmission frequency range and a parallel resonance in a midband of the respective cut-off frequency range. The diplex filter can be realized in a simple and cost-effective manner without ferrite-containing special components, for instance inductively coupled coils or tapped coils thereby allowing use thereof in a magnetic resonance tomograph, for example.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: July 10, 2012
    Assignee: Siemens Aktiengesellschaft
    Inventor: Ralph Oppelt
  • Patent number: 8212563
    Abstract: An instrument and method using electron spin resonance spectrometry for measuring the concentration of airborne soot particles, and the like, that includes continuously passing a sample of exhaust gas through a resonating RF microwave cavity resonator during the application therethrough of a uniform slowly varying uniform magnetic field that is rapidly modulated and measuring the resulting phase modulation or amplitude modulation thereof to derive an electron spin resonance signal that directly senses the concentration of carbon free radicals produced as a result of inefficient combustion of hydrocarbons during operation of the vehicle or boiler. A further invention is the use of this signal for feedback control of the engine or boiler operating parameters to minimize or substantially eliminate particulate matter emissions.
    Type: Grant
    Filed: May 6, 2009
    Date of Patent: July 3, 2012
    Assignee: Active Spectrum, Inc.
    Inventors: James Robert White, Christopher John White, Colin T. Elliott, Alexander H. Slocum
  • Patent number: 8203339
    Abstract: An apparatus comprising a magnetic field generator for generating a magnetic field of a predetermined orientation, an element provided in the apparatus at a location that, in use, is within a region of the magnetic field having the predetermined orientation generated by the generator, and a device for determining an angle between the element and the magnetic field, the device comprising a Hall Effect sensor.
    Type: Grant
    Filed: October 19, 2007
    Date of Patent: June 19, 2012
    Assignee: University of Southampton
    Inventors: Ole Gustav Johannessen, Malcolm Harris Levitt
  • Publication number: 20120133364
    Abstract: A method of and miniaturized apparatus adapted for in-situ measurement of degradation of automotive fluids and the like by micro-electron spin resonance (ESR) spectrometry, wherein the use of a modulated constant magnetic field in an RF resonating variable frequency microwave cavity resonator through which a fluid sample is passed, enables direct detection of molecular changes in such fluid sample resulting from fluid degradation during use.
    Type: Application
    Filed: February 6, 2012
    Publication date: May 31, 2012
    Inventors: James R. White, Christopher John White
  • Publication number: 20120112746
    Abstract: An apparatus and method for triaging patients according to radiation exposure operates by measuring electron paramagnetic resonance spectra of fingernails, toenails, and/or teeth. A coil structure allows in vivo measurement of tooth enamel or fingernail keratin with reduced coupling to underlying tissue.
    Type: Application
    Filed: August 25, 2010
    Publication date: May 10, 2012
    Inventors: James S. Hyde, Jason W. Sidabras, Richard R. Mett
  • Publication number: 20120049847
    Abstract: A method and system for performing pulsed electron paramagnetic resonance is disclosed. In one aspect, the method includes generating an excitation pulse train for applying to an object having probes and detecting from the probes an echo response induced by the excitation pulse train.
    Type: Application
    Filed: March 29, 2011
    Publication date: March 1, 2012
    Applicant: IMEC
    Inventors: Peter Vaes, Stephanie Teughels
  • Patent number: 8125224
    Abstract: A method of and miniaturized apparatus adapted for in-situ measurement of degradation of automotive fluids and the like by micro-electron spin resonance (ESR) spectrometry, wherein the use of a modulated constant magnetic field in an RF resonating variable frequency microwave cavity resonator through which a fluid sample is passed, enables direct detection of molecular changes in such fluid sample resulting from fluid degradation during use.
    Type: Grant
    Filed: December 9, 2008
    Date of Patent: February 28, 2012
    Assignee: Active Spectrum, Inc.
    Inventors: James R. White, Christopher J. White