With Living Organism Condition Determination Using Conductivity Effects Patents (Class 324/692)
  • Patent number: 10249039
    Abstract: A skin condition detection method adapted to detect a skin condition of each of a plurality of facial areas by a detection apparatus is provided. The skin condition detection method includes the following steps: providing an action prompt that prompts to place the detection apparatus on one of the facial areas; detecting a user action corresponding to the detection apparatus; determining if the user action including the detection apparatus corresponds to the facial area prompted by the action prompt; and when the user action including the detection apparatus corresponds to the facial area prompted by the action prompt, analyzing the skin condition of the facial area by a skin analysis method corresponding to the facial area. In addition, an electronic apparatus and a skin condition detection system using the skin condition detection method are also provided.
    Type: Grant
    Filed: July 12, 2017
    Date of Patent: April 2, 2019
    Assignee: CAL-COMP BIG DATA, INC.
    Inventors: Shyh-Yong Shen, Min-Chang Chi, Yung-Hsuan Lin
  • Patent number: 10190158
    Abstract: A circuit comprising a substrate with sectors on the substrate is provided, each sector comprising clock and data lines, a controller in electrical communication with the clock and data lines, a counter bias line, an amplifier input line and nano-electronic measurement devices on the substrate. A source of each device is coupled to the counter bias line and a drain of each device is coupled to the amplifier input line to obtain an electrical signal on the drain, the identity of which is determined by electrical interaction between the device and a charge label. Each device drain is gated by a corresponding switch between an on state, in which the drain is connected to the amplifier input line, and an off state, in which the drain is isolated from the amplifier input line. The controller controls switch states responsive to clock signal line pulses and data input line data.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: January 29, 2019
    Assignee: Pacific Biosciences of California, Inc.
    Inventors: Stephen Turner, Jonas Korlach, Steven Warren
  • Patent number: 10140427
    Abstract: The analysis of compounds utilising the physical response of cellular networks is described. Typically, the electrical characteristics of the cellular network are monitored although other characteristics such as fluorescence may be monitored. In any event, the analysis utilises signal processing techniques to derive a set of features which may be evaluated against a library of known responses. The technique may be applied to both the detection and identification of unknown compounds and the detection of concentrations of known compounds.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: November 27, 2018
    Assignee: Midas Mediscience Limited
    Inventors: Richard D. A. Heal, Alan T. Parsons
  • Patent number: 10051635
    Abstract: In one aspect, a device includes a processor and storage accessible to the processor. The storage bears instructions executable by the processor to determine that power from a secondary power source at least one of is being received and will be received. The instructions are also executable to, responsive to the determination that power from the secondary power source at least one of is being received and will be received, perform a first action regarding operating an apparatus using the secondary power source.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: August 14, 2018
    Assignee: Lenovo (Singopore) Pte. Ltd.
    Inventors: Nathan J. Peterson, Christopher Miles Osborne, Scott Edwards Kelso
  • Patent number: 10048190
    Abstract: A microfluidic particle analysis device comprising an inlet with an inlet manifold providing parallel fluid communication with a bypass channel and a measuring channel having a sensor system for detecting a particle, wherein the angle of the measuring channel relative to the main flow direction is in the range of 0° to 60°, and wherein the angle of the bypass channel relative to the main flow direction is in the range of 0° to 60°. The present invention also relates to a method of using the device microfluidic particle analysis.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: August 14, 2018
    Assignee: SBT INSTRUMENTS APS
    Inventors: Gustav Erik Skands, Christian Vinther Bertelsen
  • Patent number: 10015938
    Abstract: An irrigation system is disclosed that includes a control system for determining whether to apply a soil conditioning agent to an agricultural field is disclosed. In an implementation, the control system includes memory operable to store one or more modules and a processor coupled to the memory. The processor is operable to execute the one or more modules to cause the processor to receive one or more signals representing a soil moisture characteristic from a soil sensor. The processor is also operable to determine whether to apply a soil conditioning agent to a soil based upon the soil moisture characteristic and to initiate operation of the irrigation assembly to apply the soil conditioning agent to the soil in response when the soil requires the soil conditioning agent.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: July 10, 2018
    Assignee: Valmont Industries, Inc.
    Inventors: Craig S. Malsam, Jacob L. LaRue
  • Patent number: 9612140
    Abstract: A support device for sensors and/or actuators, of a node element or End Device (10) of a wireless network of sensors/actuators which support device comprises a base body or base module (1) with a plurality of faces (2), to which a sensor and/or actuator module or block (3) is mounted, and an electrical supply block/module (4). The main feature of the base body (1) is the possibility of adding to the node element (10) further sensors and/or actuators (3) as well as adapter elements, bridge interface elements (60) or expansion modules (50). The base body (1) can have a plurality of connection faces (2) with positive engagement means (54), which allow to assemble the above described modules. The positive engagement means (54) ensures an electromechanical connection between the many modules and, furthermore, assists an easy and intuitive accessibility for a user.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: April 4, 2017
    Assignee: WINMEDICAL S.R.L.
    Inventors: Antonio Mazzeo, Alessio Misuri, Virginia Pensabene, Sergio Scapellato, Pietro Valdastri, Monica Vatteroni
  • Patent number: 9425905
    Abstract: In various embodiments of the present disclosure, there is provided a receiver for body channel communication. The receiver includes an electrode configured to receive an incoming signal transmitted as a multi-level transmission signal from a transmitter through a body channel, a differentiator configured to obtain a time derivative of the incoming signal indicating a plurality of data transitions, and an analog to digital converter configured to generate a multi-level output signal representing the multi-level transmission signal based on the plurality of data transitions. A corresponding method of controlling a receiver for body channel communications is provided.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: August 23, 2016
    Assignee: Agency for Science, Technology and Research
    Inventors: Jung Hyup Lee, Vishal Vinayak Kulkarni, Tao Wang, Jun Zhou, Xin Liu, Minkyu Je
  • Patent number: 9041420
    Abstract: Techniques for characterizing a molecule are described herein. In one example, a portion of the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore until the trapped portion of molecule is moved within the nanopore, and the molecule is characterized based on the electrical stimulus required to affect movement of at least a portion of the trapped portion of the molecule within the nanopore.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: May 26, 2015
    Assignee: Genia Technologies, Inc.
    Inventors: Roger J. A. Chen, Randy Davis
  • Patent number: 9030187
    Abstract: A nanogap device includes a first insulation layer having a nanopore formed therein, a first nanogap electrode which may be formed on the first insulation layer and may be divided into two parts with a nanogap interposed between the two parts, the nanogap facing the nanopore, a second insulation layer formed on the first nanogap electrode, a first graphene layer formed on the second insulation layer, a first semiconductor layer formed on the first graphene layer, a first drain electrode formed on the first semiconductor layer, and a first source electrode formed on the first graphene layer such as to be apart from the first semiconductor layer.
    Type: Grant
    Filed: April 3, 2013
    Date of Patent: May 12, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Chang-seung Lee, Yong-sung Kim, Jeo-young Shim, Joo-ho Lee
  • Patent number: 9029165
    Abstract: A method for detecting electromagnetic waves derived from bacterial DNA, comprising extracting and purifying nucleic acids from a sample; diluting the extracted purified nucleic acids in an aqueous solvent; measuring a low frequency electromagnetic emission over time from the diluted extracted purified nucleic acids in an aqueous solvent; performing a signal analysis of the low frequency electromagnetic emission over time; and producing an output, based on the signal analysis, in dependence on the DNA in the sample. The DNA may be extracted from at least one of blood, feces, urine, saliva, tears, seminal fluid, sweat, seminal and vaginal fluids of a patient, or water to determine, e.g., potability. The samples may be frozen. The extracting and purifying may comprise diluting the sample with an aqueous buffer and mixing; degrading proteins in the diluted sample; precipitating DNA from the buffer solution; and resuspending the precipitated DNA in an aqueous solution.
    Type: Grant
    Filed: May 9, 2014
    Date of Patent: May 12, 2015
    Inventor: Luc Montagnier
  • Publication number: 20150109007
    Abstract: A differential amplifier is described that provides a high common mode rejection ration (CMRR) without requiring the use of precisely matched components. One variation employs a method of noise reduction to increase the SNR of the device. The differential amplifier may be used in an apparatus for measuring biopotentials of a patient, such as an electrode for measuring brain activity. The electrodes can communicate the measured biopotentials with a remote system for further processing, while providing electrical isolation to the patient.
    Type: Application
    Filed: March 29, 2012
    Publication date: April 23, 2015
    Inventor: George Townsend
  • Publication number: 20150102830
    Abstract: According to one aspect, the disclosure is directed to an example embodiment in which a circuit-based arrangement includes a circuit-based substrate securing a channel, with an effective width that is not limited by the Debye screening length, along a surface of the substrate. A pair of reservoirs are included in or on the substrate and configured for containing and presenting a sample having bio-molecules for delivery in the channel. A pair of electrodes electrically couple a charge in the sample to enhance ionic current flow therein (e.g., to overcome the electrolyte screening), and a sense electrode is located along the channel for sensing a characteristic of the biological sample by using the electrostatic interaction between the enhanced ionic current flow of the sample and the sense electrode. Actual detection occurs by using a charge-signal processing circuit to process the sensed charge signal and, therefrom, provide an output indicative of a signature for the bio-molecules delivered in the channel.
    Type: Application
    Filed: October 16, 2014
    Publication date: April 16, 2015
    Inventors: Yang Liu, Robert W. Dutton, Roger T. Howe
  • Publication number: 20150102829
    Abstract: The objective of the present invention is to provide a fingerprint sensor package having a novel structure and a method for manufacturing same, the fingerprint sensor package enabled with obtaining an accurate fingerprint image by minimizing the distance between a top surface of a sensing portion in a fingerprint sensor and a fingerprint, so as to improve mechanical strength and tolerance to electrostatic discharge compared to existing fingerprint sensor packages.
    Type: Application
    Filed: May 14, 2013
    Publication date: April 16, 2015
    Applicant: CRUCIALTEC CO., LTD
    Inventors: Dong Nam Son, Young Moon Park, Ki Don Kim
  • Publication number: 20150091592
    Abstract: A system for determining usability of an analytical test strip having two electrodes connected in series with a sample cell includes a test meter configured to receive the test strip. The sample cell receives a fluid sample, the sample cell with the received fluid sample having a frequency-dependent impedance. A microprocessor and circuit in the test meter cause application of an AC waveform across the sample cell via the electrodes upon detection of sample in the sample cell and concurrently measure of a current through the electrodes. The AC waveform has a frequency at which the characteristic impedance is substantially zero. The measured current is inversely proportional to a series resistance of the two electrodes. A hand-held test meter and a method for determining usability of an analytical test strip are also described.
    Type: Application
    Filed: September 30, 2013
    Publication date: April 2, 2015
    Applicant: Cilag GmbH International
    Inventor: David ELDER
  • Publication number: 20150077142
    Abstract: A planar sensor having a conductor pattern for electric field sensing and its manufacturing method, the planar sensor comprising arrays of planar electrically conductive sensor areas (2) arranged to follow each other in a successive manner along the longitudinal direction, and conductors connecting electrically conductive sensor area to at least one connector, wherein the sensor further comprises a first elastic flooring layer (3) and at least one of the following: a second elastic flooring layer (4) or a flexible circuit board, and the electrically conductive sensor areas (2) and the conductors are attached between the first elastic flooring layer (3) and the second elastic flooring layer (4) or between the first elastic flooring layer (3) and the flexible circuit board to form a unitary floor sensor structure.
    Type: Application
    Filed: September 4, 2012
    Publication date: March 19, 2015
    Applicant: ELSI TECHNOLOGIES OY
    Inventors: Temmo Pitkänen, Juha Lindström
  • Patent number: 8975901
    Abstract: Measurement devices, systems, and methods to measure a high field conductivity of a fluid are provided herein. The measurement device includes a fluid cell, a pair of electrodes, a voltage switch, and a measurement unit. The fluid cell is on an inclined plane to receive the fluid. The pair of electrodes are connected to the fluid cell. The pair of electrodes are spaced apart from one another to receive the fluid therebetween and positioned parallel to one another to pass an electrical current therethrough. The power unit provides a high voltage power supply to one electrode of the pair of electrodes. The measurement unit measures the electrical current that passes between the pair of electrodes through the fluid.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: March 10, 2015
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Henryk Birecki, Omer Gila, Michael H Lee, William D Holland
  • Patent number: 8937478
    Abstract: An electrostatic occupant detection system includes an electrostatic sensor and an electronic control unit. The electronic control unit is switchable between an occupant determination state in which the electronic control unit outputs a sine wave having a constant amplitude and a diagnosis state in which the electronic control unit maintains a voltage of the electrostatic sensor at a constant level. The electronic control unit gradually changes at least one of an amplitude and a frequency of the sine wave either when the electronic control unit switches from the occupant determination state to the diagnosis state and/or when the electronic control unit switches from the diagnosis state to the occupant determination state.
    Type: Grant
    Filed: May 9, 2011
    Date of Patent: January 20, 2015
    Assignees: Denso Corporation, Freescale Semiconductor, Inc.
    Inventors: Ryo Shimizu, Craig M. Aykroyd, John M. Pigott
  • Publication number: 20150002177
    Abstract: Apparatus for use in performing impedance measurements on a subject. The apparatus includes a processing system for causing a first signal to be applied to the subject, determining an indication of a second signal measured across the subject, using the indication of the second signal to determine any imbalance and if an imbalance exists, determining a modified first signal in accordance with the imbalance and causing the modified first signal to be applied to the subject to thereby allow at least one impedance measurement to be performed.
    Type: Application
    Filed: September 12, 2014
    Publication date: January 1, 2015
    Inventors: Scott Chetham, Christopher Newton Daly, Ian John Bruinsma
  • Patent number: 8860442
    Abstract: According to an embodiment of the present invention, a method of determining or adjusting the sensitivity of a biosensor arrangement comprising at least one field effect biosensor is provided, each of the at least one field effect biosensor comprising: a semiconductor substrate comprising a source region, a drain region and a channel region disposed between the source region and the drain region; a gate isolation layer covering the channel region; and a reference electrode disposed over the gate isolation layer such that a electrolytic solution to be sensed can be provided between the reference electrode and the gate isolation layer.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: October 14, 2014
    Assignee: Agency for Science, Technology and Research
    Inventors: Minkyu Je, Guo-Jun Zhang, Tshun Chuan Chai, Cheng Fang
  • Patent number: 8841928
    Abstract: In an organic EL panel inspection method, to determine whether an organic EL panel is good or bad, a plurality of voltages having different values are sequentially applied to the organic EL panel, thereby measuring the respective currents. According to the currents, the following three criteria are checked: criterion (1), whether or not a spike current is present in the measured currents, criterion (2), between when the plurality of voltages are sequentially applied from one direction to the other direction of the voltage and when the plurality of voltages are sequentially applied from the other direction to the one direction, whether or not currents having different current densities occur at the same voltage, and criterion (3), the absolute value of the current density of current flowing when a predetermined voltage in the reverse direction is applied to the organic EL panel.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: September 23, 2014
    Assignee: Konica Minolta Holdings, Inc.
    Inventors: Keiichi Furukawa, Kuniaki Uezawa, Toshiyuki Kinoshita
  • Patent number: 8810236
    Abstract: An analyte sensor apparatus and a corresponding fluid medium, the analyte sensor apparatus comprising a sensing element, the external surface of which comprises a membrane to inhibit exposure of the sensing element; the corresponding fluid medium comprising a receptor species and an activatable species, the receptor species for interacting with an analyte to activate the activatable species, activation of the activated species causing increased porosity of the membrane of an in-contact analyte sensor apparatus to correspondingly increase exposure of the sensing element to allow for production of a detectable electrical signal which can be used to sense the presence of the analyte.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: August 19, 2014
    Assignee: Nokia Corporation
    Inventors: Marc J A Bailey, Elisabetta Spigone
  • Patent number: 8797025
    Abstract: A source-measure unit (SMU) may be implemented with respective digital control loops for output voltage and output current. The output voltage and output current may be measured with dedicated ADCs (analog-to-digital converters). The readings obtained by the ADCs may be compared to a setpoint, which may be set in a digital loop controller. The digital loop controller may be used to produce an output to drive a DAC (digital-to-analog converter) until the output voltage and/or output current and/or a function thereof reach the respective desired levels. The digital loop controller may implement respective integrating functions for the respective digital control loops, and may also implement a compensation function featuring pole-zero pairs to stabilize the respective current/voltage outputs. Coefficients of the compensation function may be calculated based on user programmable parameters corresponding to the gain bandwidth product, compensation frequency, and ratio of the added pole-zero frequencies.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: August 5, 2014
    Assignee: National Instruments Corporation
    Inventors: Christopher G. Regier, L. Rolando Ortega-Pohlenz
  • Patent number: 8760178
    Abstract: [Object] To provide a method for measuring a target component in an erythrocyte-containing specimen with high reliability while suppressing the influence of the Ht value of the specimen. [Solution to Problem] In the measurement method of the present invention, first, prior to measurement, a relationship between amounts of the target component and a plurality of signals corresponding thereto is provided. Then, a plurality of signals derived from the target component in the erythrocyte-containing specimen are acquired with a biosensor. With reference to the relationship, the amount of the target component in the specimen is determined based on the thus-acquired plurality of signals.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: June 24, 2014
    Assignee: Arkray, Inc.
    Inventor: John James Rippeth
  • Patent number: 8736287
    Abstract: A detection system and method for detecting one or a plurality of species from a mixture of species in a phase. The detection system and method detect changes in conductance induced by the species. The conductance includes a cell structure having a rigid architecture having a top surface a portion of which is electrically conductive forming a first conductive component. A second conductive component substantially overlaps the first conductive component and is spaced from the first conductive component by an insulating component. One or more flow pathways exist between the first conductive component and the second conductive component for the chemical and/or biological species to flow. A time dependent electrical signal for inducing a time dependent response is applied to at least one of said first and second conductive components and a signal detector coupled to at least one of the first and second conductive components measures the time dependent response.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: May 27, 2014
    Assignee: Universal Nanosensor Technologies Inc.
    Inventors: Al-Amin Dhirani, Yoshinori Suganuma
  • Patent number: 8736250
    Abstract: A method for detecting electromagnetic waves derived from bacterial DNA, comprising extracting and purifying nucleic acids from a sample; diluting the extracted purified nucleic acids in an aqueous solvent; measuring a low frequency electromagnetic emission over time from the diluted extracted purified nucleic acids in an aqueous solvent; performing a signal analysis of the low frequency electromagnetic emission over time; and producing an output, based on the signal analysis, in dependence on the DNA in the sample. The DNA may be extracted from at least one of blood, feces, urine, saliva, tears, seminal fluid, sweat, seminal and vaginal fluids of a patient, or water to determine, e.g., potability. The samples may be frozen. The extracting and purifying may comprise diluting the sample with an aqueous buffer and mixing; degrading proteins in the diluted sample; precipitating DNA from the buffer solution; and resuspending the precipitated DNA in an aqueous solution.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: May 27, 2014
    Inventor: Luc Montagnier
  • Patent number: 8725245
    Abstract: An oscillator provides a reference signal having a phase. A tunable reactive circuit, including an induction coil, is driven by the fixed frequency reference signal of the oscillator with coil adapted to be positioned adjacent the specimen to generate an oscillating signal corresponding to the condition of the specimen. The tunable reactive circuit provides an output signal having a parameter indicative of the condition of the specimen. A resonant control circuit compares the reference signal to the oscillating signal and provides to the tunable reactive circuit a resonance control signal representative of the comparison. The resonance control signal tunes the tunable reactive circuit, which may be a series RLC circuit, so that the frequency of the oscillating signal is substantially constant.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: May 13, 2014
    Assignee: Kimberly-Clark Worldwide, Inc.
    Inventors: Joseph R. Feldkamp, Jeffrey R. Heller, Shawn J. Sullivan
  • Patent number: 8725424
    Abstract: Systems and methods for estimating a physical characteristic of a seafood product are provided. In one system, the estimate is based on a slope defined by a ratio of changes in peak resonant amplitude and frequency of an electromagnetic resonant circuit in loaded and unloaded states. In another system, a first probe of a plurality of probes is driven with a test signal when the plurality of probes is loaded by a seafood product and the estimate is based on received test signals at one or more of the other probes. In another system, the estimate is based on the loading effect of a seafood product on an electromagnetic resonant circuit, which is also used to read an ID from an RFID associated with the seafood product. The systems and methods may be used for individual specimens, or to determine an average estimate for multiple specimens at one time.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: May 13, 2014
    Assignee: Clearwater Seafoods Limited Partnership
    Inventors: Timothy A. Burke, Peter H. Gregson, Gleb J. Sekretta, Stephen J. F. Hankinson
  • Patent number: 8642287
    Abstract: Methods and apparatus for designing and measuring a cell-electrode impedance sensor to detect chemical and biological samples, including biological cells. The method of designing a cell-electrode impedance sensor comprises: determining a cell free cell-electrode impedance and a cell-covered cell-electrode impedance; obtaining a sensor sensitivity of the cell-electrode impedance measurement system; and choosing one or more design parameters of the cell-electrode impedance sensor to maximize the sensor sensitivity. When the frequency of AC signal between electrodes ranges from 10 kHz to 40 kHz, the sensitivity of the sensor is maximized.
    Type: Grant
    Filed: July 25, 2007
    Date of Patent: February 4, 2014
    Assignee: CapitalBio Corporation
    Inventors: Lei Wang, Keith Mitchelson, He Wang, Jing Cheng
  • Patent number: 8633033
    Abstract: A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample.
    Type: Grant
    Filed: December 21, 2012
    Date of Patent: January 21, 2014
    Assignee: The Regents of the University of California
    Inventors: Boris Rubinsky, Cesar A. Gonzalez
  • Patent number: 8604810
    Abstract: Arrays of biosensors are provided along with methods for operating the arrays of biosensors. The array of biosensors may include a first reference electrode that is connected to an input of a first control amplifier; a first working electrode and a second working electrode in proximity with the first reference electrode; and a counter electrode that is connected to at least an output of the first control amplifier, where the first control amplifier is operative with the counter electrode to maintain a first specified voltage between the first working electrode and the first reference electrode, and between the second working electrode and the first reference electrode.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: December 10, 2013
    Assignee: MicroCHIPS, Inc.
    Inventor: Norman F. Sheppard, Jr.
  • Patent number: 8587327
    Abstract: A device for use with a conduit having a first conduit end and a conduit second end, into which conduit a cable can be installed using a flow of air into the first conduit end, the device being suitable for confirming that the air is flowing out from the second conduit end. In an embodiment, the device includes a housing, means to enable connection of the device to the second conduit end, a detector arranged to detect an electrical property change, and an actuator for causing an electrical property change detectable by the detector, wherein in use, the air flowing into the device causes the detector and the actuator to move relative to each other, causing an electrical property change detectable by the detector.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: November 19, 2013
    Assignee: British Telecommunications Public Limited Company
    Inventors: David John Taylor Heatley, Philip Alfred Barker, Ian Neild
  • Patent number: 8558563
    Abstract: In a first embodiment, electrodes are coupled to a surface at first, second, and third locations, the first location being further from the third location than from the second location. Impedance is measured at distinct frequencies between pairs of the electrodes. As a result, impedance is measured at differing regions below the surface, one region being deeper below the surface than the other region. In a second embodiment, a microfluidic device carries out an analysis. The analysis may be within a flexible patch adhered to a surface, or may be in a solid device implanted in a body of liquid surrounded by tissue. The analysis may involve pumping a fluid or may involve drawing an analyte electrophoretically through a microfluidic channel.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: October 15, 2013
    Assignee: Proteus Digital Health, Inc.
    Inventor: Mark J. Zdeblick
  • Patent number: 8525533
    Abstract: A conductivity detector detects the electrical conductivity of a fluid under analysis for determining chemical or physical properties of the fluid that are related its electrical properties. Such conductivity detectors may find use in, for example, hemodialysis systems for analyzing the effectiveness of the hemodialysis treatment. In an aspect, to improve accuracy of the conductivity measurements, the detector utilizes four-wire resistance measurement methods. In another aspect, to avoid fouling or contamination of the electrodes, the detector utilizes capacitively-coupled contactless conductivity detection (C4D) methods so that the electrodes are physically unconnected to the fluid contained in a fluid chamber. In a possible further aspect, the fluid chamber may be a disposable component removable from the electrodes. The conductivity detector can include other features such as calibration circuits and features for electrically isolating the fluid under detection from the fluid in the rest of the system.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: September 3, 2013
    Assignee: Fresenius Medical Care Holdings, Inc.
    Inventor: Thomas A. Sullivan
  • Publication number: 20130214801
    Abstract: A method and apparatus for sensing a fingerprint has an array of sensors, each sensor having a sensing surface for receiving the pressure of a finger and having an ITO layer that has an intrinsic variable resistance characteristic that varies because of the varying ridges and valleys of a finger. The intrinsic variable resistance characteristic is converted to a variable voltage for a given pixel based on the pressure applied by the finger, and the fingerprint is determined based on the variable voltage readings for each pixel.
    Type: Application
    Filed: February 17, 2012
    Publication date: August 22, 2013
    Applicant: JP SENSOR CORPORATION
    Inventor: Hsu-Feng Hsiao
  • Publication number: 20130169296
    Abstract: An impedance analyzer includes: a control voltage generating unit for generating a control voltage that has a predetermined amplitude value; a measuring unit operable to provide an output current, which has an amplitude value corresponding to that of the control voltage, for flowing through first and second body portions of a biological target, and to generate a measurement voltage that has an amplitude value corresponding to a difference between voltages at the first and second body portions attributed to flow of the output current therethrough; and a calculating module operable to determine an electrical impedance between the first and second body portions according to a predetermined adjustment value and the amplitude value of the measurement voltage.
    Type: Application
    Filed: July 23, 2012
    Publication date: July 4, 2013
    Applicant: NATIONAL CHI NAN UNIVERSITY
    Inventors: Tak-Shing Ching, Tai-Ping Sun, Chia-Ming Liu
  • Patent number: 8466694
    Abstract: A biometric measurement apparatus has a measurement unit for measuring bioelectric impedance of different parts of a body and hematocrit. The measurement unit has impedance calculators (IPG1, IPG2) for measuring the impedance of tissues and blood of a living body with a first frequency to output as a first impedance (Z1), and for measuring the impedance of the tissues and blood of the living body with a second frequency to output as a second impedance (Z2), and has pulse wave analyzing units (MS1 and MS2) for analyzing differences of the first impedance between a first time and a second time and difference (?ZH) of the second impedance between the first time and the second time, and a hematocrit calculator (245) for calculating hematocrit based on the difference (?ZL) of the first impedance and the difference (?ZH) of the second impedance.
    Type: Grant
    Filed: October 1, 2010
    Date of Patent: June 18, 2013
    Assignee: Tanita Corporation
    Inventors: Tomio Sato, Tadaaki Ishige
  • Publication number: 20130149774
    Abstract: A cell counter system includes an inlet via which a fluid containing a plurality of cells inflows; a channel in which the fluid flows; a valve unit, which controls flow of the fluid in the channel; an electrode unit, which is arranged in the channel for measuring impedance for counting a number of the plurality of cells; and an outlet, which is connected to the channel to drain the fluid.
    Type: Application
    Filed: September 13, 2012
    Publication date: June 13, 2013
    Applicant: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Min-seok KIM, Tae-seok SIM, Yeon-jeong KIM, Sang-hyun BAEK, Jin-mi OH, Hyo-young JEONG, Jeong-gun LEE
  • Patent number: 8461854
    Abstract: Techniques for characterizing a molecule are described herein. In one example, a portion of the molecule is trapped in a nanopore, a variable voltage is applied across the nanopore until the trapped portion of molecule is moved within the nanopore, and the molecule is characterized based on the electrical stimulus required to affect movement of at least a portion of the trapped portion of the molecule within the nanopore.
    Type: Grant
    Filed: September 15, 2012
    Date of Patent: June 11, 2013
    Assignee: Genia Technologies, Inc.
    Inventors: Roger Chen, Randy Davis
  • Patent number: 8427181
    Abstract: A follower amplifier with power supply biased by a controlled voltage source such that the power supply potentials are, for the frequencies of interest, as close as possible to the potential of the follower output. There is proposed a front-end electronic circuit for biopotential and impedance measurements with outstanding performances (very high input impedance and gain very close to unity). Preferably, the explicit guard electrode and the explicit electronic unit at the belt are no longer necessary; all electronics is embedded in units placed directly at the measurement sites. Moreover, the proposed front-end electronic circuit allows a drastic simplification of the cabling and connectors since all units are connected to only one wire (the theoretical minimum) for potential reference and current return. Preferably, this wire does not even require an electrical isolation and can be easily embedded in the textile of a shirt, in a garment, mesh, belt, etc.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: April 23, 2013
    Assignee: CSEM Centre Suisse d' Electronique et de Microtechnique SA—Recherche et Developpement
    Inventors: Olivier Chetelat, Josep Sola I Caros
  • Patent number: 8421484
    Abstract: A method for measuring membrane potential using dielectric spectroscopy is described. A new theoretical model allows for the determination of membrane potential from low-frequency impedance measurements to provide a non-evasive method which is both rapid and inexpensive.
    Type: Grant
    Filed: July 30, 2008
    Date of Patent: April 16, 2013
    Assignees: Purdue Pharma L.P., New Jersey Institute of Technology
    Inventors: Camelia Prodan, Victor I. Ilyin, Donald J. Kyle, Kevin Carlin, Gang Wu
  • Publication number: 20130082722
    Abstract: The present invention relates to a method of forming a nanopore and a structure formed with the nanopore. The present invention relates to a method of forming a nanopore by preparing a first structure and a second structure having a surface on which nucleotides can be attached; attaching one ends of a plurality of oligonucleotides complementary to each other on the surface; binding the first structure and the second structure; and removing some of the bound oligonucleotides. The present invention is effective in that a pore of a desired size can be accurately formed by adjusting the length of the oligonucleotides.
    Type: Application
    Filed: September 25, 2012
    Publication date: April 4, 2013
    Applicant: LG ELECTRONICS INC.
    Inventor: LG ELECTRONICS INC.
  • Patent number: 8384402
    Abstract: The present invention relates to an analysis tool including a reagent portion and electrodes. The electrodes include a porous conductive portion where the reagent portion is formed. The porous conductive section is formed by, for instance, coating at least a part of a surface and an inner surface of a porous body with a conductive film. The porous body is, for instance, an insulating fiber mesh cloth. Preferably, the electrodes are formed in a sheet shape.
    Type: Grant
    Filed: October 31, 2008
    Date of Patent: February 26, 2013
    Assignee: Arkray, Inc.
    Inventor: Yoshiharu Sato
  • Publication number: 20130027064
    Abstract: An analyte test sensor strip is disclosed having information coded thereon as well as a method of forming the same and conducting an analyte test using the analyte test sensor strip. Information relating to an attribute of the strip or batch/lot of strips may be coded based on resistance values pertaining to electrical aspects of the strip, such as a primary resistive element and a secondary resistive element, the secondary resistive element having one of a plurality of states defined by a location of a closed tap to form a unique resistive path for the secondary resistive element that includes a portion of the primary resistive element depending on the location of the closed tap. The states may be formed on the strip by a secondary processing step in the manufacture of the strip in which a plurality of taps are severed leaving only one tap in a closed state.
    Type: Application
    Filed: July 29, 2011
    Publication date: January 31, 2013
    Applicant: ROCHE DIAGNOSTICS OPERATIONS, INC.
    Inventors: John T. Austera, Terry A. Beaty, Abner D. Joseph, Nathan E. Manlove, Steven K. Moore, James L. Pauley, JR., Randall K. Riggles
  • Patent number: 8361391
    Abstract: A method and apparatus of determining the condition of a bulk tissue sample, by: positioning a bulk tissue sample between a pair of induction coils (or antennae); passing a spectrum of alternating current (or voltage) through a first of the induction coils (or antennae); measuring spectrum of alternating current (or voltage) produced in the second of the induction coils (or antennae); and comparing the phase shift between the spectrum of alternating currents (or voltages) in the first and second induction coils (or antennae), thereby determining the condition of the bulk tissue sample.
    Type: Grant
    Filed: December 16, 2011
    Date of Patent: January 29, 2013
    Assignee: The Regents of the University of California
    Inventors: Boris Rubinsky, Cesar A. Gonzalez
  • Patent number: 8344742
    Abstract: The invention provides methods of investigating a mechanism of action of a compound, which includes providing a device for monitoring cell-substrate impedance; attaching the device to an impedance analyzer; adding cells to two or more wells; adding a test compound to at least one of the wells and providing at least one control well; monitoring impedance of the wells to obtain a series of impedance measurements; plotting impedance measurements to obtain impedance curves and comparing the impedance curves to determine a time frame at which the test compound has a significant effect on cell growth or behavior. Determining the time frame provides information on changes in cell status in response to the test compound, including cell attachment or adhesion status, cell growth or proliferation status, the number of viable or dead cells, cytoskeletal organization or structure, and the number of cells going through apoptosis or necrosis.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: January 1, 2013
    Assignee: ACEA Biosciences, Inc.
    Inventors: Yama A. Abassi, Xiaobo Wang, Xiao Xu
  • Publication number: 20120326732
    Abstract: The present disclosure includes a sensor and method for detecting a target molecule. In one instance, a sensor comprises a substrate including a hole, a first insulating layer located on the substrate and including a first nanopore corresponding to the hole, a first electrode, a second electrode, wherein the first electrode and the second electrode are located on a surface of the first insulating layer and are spaced apart by the first nanopore forming a nanogap, and a modulation unit configured to apply a unit input signal between the first electrode and the second electrode, wherein at least one unit input signal is applied as a target molecule passes through the nanogap.
    Type: Application
    Filed: May 18, 2012
    Publication date: December 27, 2012
    Applicant: SAMSUNG ELECTRONIC CO., LTD.
    Inventors: Seong-ho CHO, Dong-ho LEE, Jeo-young SHIM
  • Publication number: 20120292255
    Abstract: This disclosure provides methods to use nanoparticles as non-optical tags for detecting a change in mass. chemical sensing or bio-sensing events or reaction upon conjugation of nanoparticles onto a thermoresistor heat sensor. Particularly described is the use of metal nanoparticles in thermal sensors, thermal bio-sensors, and sensing pixel arrays for multiple analyte sensing. In addition, an asymmetric filter is disclosed that allows size separation of molecules from nanoparticles. The asymmetric filter is a porous membrane that is designed to have a small pore size in one size and a large pore size on the other side.
    Type: Application
    Filed: May 16, 2012
    Publication date: November 22, 2012
    Inventor: Babak Nikoobakht
  • Patent number: 8289035
    Abstract: An unadjusted ion population is obtained by measurement of an unadjusted charge transfer due to an imposed electrical potential between two surfaces within a plant. An adjusted ion population is determined by dividing the unadjusted charge transfer by the wetted surface area through which the charge transfers occurs. Changes in wetted surface area are measured by changes in the electrical capacitance of the surface/liquid interface. The type of ion is identified by application of a sequence of potential values imposed on the two surfaces by a source which permits the potential of the electron emitting surface to take on a value set by the ion involved in the electron transfer. The ion is identified by the value of this potential.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: October 16, 2012
    Inventor: William George Gensler
  • Patent number: RE43815
    Abstract: An electrochemical biosensor test strip with four new features. The test strip includes an indentation for tactile feel as to the location of the strips sample application port. The sample application port leads to a capillary test chamber, which includes a test reagent. The wet reagent includes from about 0.2% by weight to about 2% by weight polyethylene oxide from about 100 kilodaltons to about 900 kilodaltons mean molecular weight, which makes the dried reagent more hydrophilic and sturdier to strip processing steps, such as mechanical punching, and to mechanical manipulation by the test strip user. The roof of the capillary test chamber includes a transparent or translucent window which operates as a “fill to here” line, thereby identifying when enough test sample (a liquid sample, such as blood) has been added to the test chamber to accurately perform a test. The test strip may further include a notch located at the sample application port. The notch reduces a phenomenon called “dose hesitation”.
    Type: Grant
    Filed: November 21, 2011
    Date of Patent: November 20, 2012
    Assignees: Roche Diagnostics Operations, Inc., Roche Operations Ltd.
    Inventors: William F. Crismore, Nigel A. Surridge, Daniel R. McMinn