With Gas Or Vapor Treating Patents (Class 34/298)
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Patent number: 11480390Abstract: A freeze-drying device includes a controller configured to control depressurization of containers filled with a liquid including a raw material and a medium to freeze the liquid from a liquid surface. The freeze-drying device also includes a gas capture pump configured to exhaust a freeze-drying chamber accommodating the containers, and a positive-displacement pump configured to discharge gas from a space accommodating the gas capture pump. The controller executes an exhaust mitigation process that performs the depressurization at an exhaust capability that is less than a rated exhaust capability of the freeze-drying device. The controller uses a partial pressure value of the medium to determine when the exhaust mitigation process ends. The controller maintains an exhaust speed of the gas capture pump and decreases an exhaust speed of the positive-displacement pump in the exhaust mitigation process.Type: GrantFiled: February 28, 2022Date of Patent: October 25, 2022Assignee: ULVAC, INC.Inventors: Tsuyoshi Yoshimoto, Yoichi Ohinata, Tomomitsu Ozeki
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Patent number: 9470453Abstract: A method of controlling and enhancing the nucleation of product in a freeze dryer wherein a product is maintained at a predetermined temperature and pressure. A mixture of water vapor and CO2 gas is introduced into a condenser chamber separate from the product chamber to create a predetermined volume of condensed frost, ice and dry ice crystals on an inner surface of the condenser chamber. The condenser chamber is connected to the product chamber and has a predetermined pressure that is greater than that of the product chamber. Upon the opening of the condenser chamber into the product chamber, gas turbulence is created that causes the condensed frost in the form of an ice fog and accompanying ice and dry ice crystals to rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.Type: GrantFiled: August 6, 2013Date of Patent: October 18, 2016Assignee: Millrock Technology, Inc.Inventor: Weijia Ling
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Patent number: 9435586Abstract: A method of controlling and enhancing the nucleation of product in a freeze dryer, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of condensed frost is created on an inner surface of a condenser chamber separate from the product chamber and connected thereto by a vapor port. The opening of the vapor port into the product chamber when the condenser chamber has a pressure that is greater than that of the product chamber creates gas turbulence that breaks down the condensed frost into ice crystals that rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.Type: GrantFiled: March 12, 2014Date of Patent: September 6, 2016Assignee: MILLROCK TECHNOLOGY, INC.Inventor: Weijia Ling
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Publication number: 20150128446Abstract: A shelf for a freeze dryer and method for enhancing temperature uniformity across the shelf. In one embodiment, the shelf has a lower shelf plate and an upper shelf plate mounted on the lower shelf plate and channels in a serpentine pattern are positioned between the upper and lower shelf plates to circulate heating or cooling fluid in a counter-flow pattern therebetween for temperature uniformity. The upper-shelf plate is formed of a temperature conductive material.Type: ApplicationFiled: November 4, 2014Publication date: May 14, 2015Inventor: Weijia LING
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Publication number: 20150040420Abstract: A method of controlling and enhancing the nucleation of product in a freeze dryer wherein a product is maintained at a predetermined temperature and pressure. A mixture of water vapor and CO2 gas is introduced into a condenser chamber separate from the product chamber to create a predetermined volume of condensed frost, ice and dry ice crystals on an inner surface of the condenser chamber. The condenser chamber is connected to the product chamber and has a predetermined pressure that is greater than that of the product chamber. Upon the opening of the condenser chamber into the product chamber, gas turbulence is created that causes the condensed frost in the form of an ice fog and accompanying ice and dry ice crystals to rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.Type: ApplicationFiled: August 6, 2013Publication date: February 12, 2015Applicant: Millrock Technology, Inc.Inventor: Weijia Ling
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Patent number: 8875413Abstract: A method of controlling and enhancing the nucleation of product in a freeze dryer, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of condensed frost is created on an inner surface of a condenser chamber separate from the product chamber and connected thereto by a vapor port. The condenser chamber has a predetermined pressure that is greater than that of the product chamber. The opening of the vapor port into the product chamber creates gas turbulence that breaks down the condensed frost into ice crystals that rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.Type: GrantFiled: August 13, 2012Date of Patent: November 4, 2014Assignee: Millrock Technology, Inc.Inventor: Weijia Ling
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Patent number: 8839528Abstract: A method of controlling and enhancing the nucleation of product in a freeze dryer, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of ice fog is created in a condenser chamber separate from the product chamber and connected thereto by a vapor port. The ice fog has a predetermined pressure that is greater than that of the product chamber, and is rapidly conveyed through the vapor port into the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.Type: GrantFiled: April 29, 2011Date of Patent: September 23, 2014Assignee: Millrock Technology, Inc.Inventor: Weijia Ling
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Patent number: 8800162Abstract: A method for monitoring and/or controlling and a freeze drying process in a freeze dryer apparatus provided with a drying chamber having a temperature-controlled shelf supporting containers of a product to be dried, comprises during a primary drying phase of the freeze drying process the steps of: isolating the drying chamber closing an isolating valve thereof and sensing and collecting pressure values inside the drying chamber for a defined pressure collecting time and a shelf temperature of the temperature-controlled shelf (Step 1); calculating a product temperature of product and a plurality of process/product related parameters (Step 2); calculating a new shelf temperature and a sequence of shelf temperatures up to the end of the primary drying phase, that maximizes a sublimation rate of the product maintaining the product temperature below a maximum allowable product temperature.Type: GrantFiled: September 19, 2007Date of Patent: August 12, 2014Assignee: Azbil Telstar Technologies, S.L.Inventors: Salvatore Velardi, Antonello Barresi
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Patent number: 8793896Abstract: A device for controlling the dehydration operation during a freeze-drying treatment comprises a freeze-drying chamber (1) connected to a vacuum line, and a gas analyzer, for analyzing the gases contained in the chamber. The gas analyzer comprises a gas ionization system (8) comprising a plasma source (13) in contact with the gases, which plasma source is combined with a generator (15) capable of generating a plasma from said gases, and a system for analyzing the ionized gases, comprising a radiation sensor (17) located close to the plasma generation zone and connected to an apparatus (18) for analyzing the change in the radiative spectrum emitted by the plasma. According to the invention, the device includes a means (16) for repeatedly turning the plasma source (13) on and off. The device may further include an optical port (25) placed between the gas ionization system (8) and the freeze-drying chamber (1).Type: GrantFiled: February 1, 2011Date of Patent: August 5, 2014Assignee: Adixen Vacuum ProductsInventors: Ketan Patel, Didier Pierrejean, Cyrille Nomine, Aurélie Chapron
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Publication number: 20140202025Abstract: A method of controlling and enhancing the nucleation of product in a freeze dryer, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of condensed frost is created on an inner surface of a condenser chamber separate from the product chamber and connected thereto by a vapor port. The opening of the vapor port into the product chamber when the condenser chamber has a pressure that is greater than that of the product chamber creates gas turbulence that breaks down the condensed frost into ice crystals that rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.Type: ApplicationFiled: March 12, 2014Publication date: July 24, 2014Applicant: MILLROCK TECHNOLOGY, INC.Inventor: WEIJIA LING
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Patent number: 8758681Abstract: A free radical sterilization system having a chamber defining a region, and a generator for generating free radical reach effluent from a free radical electric generator and/or a vaporizer. A closed loop circulating system without a free-radical destroyer is provided for supplying the mixture of free radicals from the electric generator mixed with the hydrogen peroxide solution in the form of the effluent to the chamber. The free-radical sterilization system is used in sterilizing items in the chamber and, with an open-bottomed wound chamber, in treating wounds on a body.Type: GrantFiled: June 15, 2012Date of Patent: June 24, 2014Inventor: Czeslaw Golkowski
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Publication number: 20140041250Abstract: A method of controlling and enhancing the nucleation of product in a freeze dryer, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of condensed frost is created on an inner surface of a condenser chamber separate from the product chamber and connected thereto by a vapor port. The condenser chamber has a predetermined pressure that is greater than that of the product chamber. The opening of the vapor port into the product chamber creates gas turbulence that breaks down the condensed frost into ice crystals that rapidly enter the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.Type: ApplicationFiled: August 13, 2012Publication date: February 13, 2014Inventor: Weijia Ling
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Publication number: 20130263467Abstract: A device for a supplying a gas flow to products, for example for a dry or freeze procedure, comprising a top and bottom grid, which are located parallel at a certain distance above each other, which top and bottom grid are both provided with a large amount of passage openings for the gas flow and in which, during operating, the to the gas flow subject products can be arranged on the upper grid, as well as flow generating means for generating and for providing the gas flow through the top and bottom grid towards the products. According to the invention the distance between the top and bottom grid is at least substantially equal to the diameter of the balls such that the balls are only able to be arranged in a single layer between the grids.Type: ApplicationFiled: April 5, 2013Publication date: October 10, 2013Applicant: Mooij Agro B.V.Inventor: Maarten Mooij
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Publication number: 20130006546Abstract: A freeze-drying process includes a primary drying phase. Within this phase, a test is performed for causing a variation of partial pressure of solvent inside a drying chamber. At the beginning of the test, a product sublimation flux, a total pressure and a partial pressure of the solvent in the drying chamber are measured. A product temperature is estimated at the interface of sublimation at the beginning of the test. The solvent vapor pressure at the interface of sublimation is calculated as is a resistance of a dried layer of the product to the vapor flow of the solvent. Next, a thickness of a frozen layer of the product is calculated and a coefficient of heat transfer between heating surface and product is also calculated. An initial temperature profile of the frozen product is then calculated as is a total pressure in the drying chamber. A value of the product temperature at the interface of sublimation at the beginning of test is determined and a time constant of the freeze-drying process is calculated.Type: ApplicationFiled: December 22, 2010Publication date: January 3, 2013Applicant: TELSTAR TECHNOLOGIES, S.L.Inventors: Davide Fissore, Roberto Pisano, Antonello A. Barresi
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Publication number: 20120272544Abstract: A method of controlling and enhancing the nucleation of product in a freeze dryer, wherein the product is maintained at a predetermined temperature and pressure in a chamber of the freeze dryer, and a predetermined volume of ice fog is created in a condenser chamber separate from the product chamber and connected thereto by a vapor port. The ice fog has a predetermined pressure that is greater than that of the product chamber, and is rapidly conveyed through the vapor port into the product chamber for even distribution therein to create uniform and rapid nucleation of the product in different areas of the product chamber.Type: ApplicationFiled: April 29, 2011Publication date: November 1, 2012Applicant: Millrock Technology, Inc.Inventor: Weijia Ling
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Publication number: 20110179667Abstract: A method for distributing a cryogenic fluid inside a freeze drying chamber. The cryogenic fluid is fed into the freeze drying chamber through a venturi device. The cryogenic fluid will form an ice fog which will be rapidly and uniformly distributed throughout the freezing chamber and into the vials present in the freezing chamber.Type: ApplicationFiled: September 15, 2010Publication date: July 28, 2011Inventors: Ron C. Lee, Prerona Chakravarty
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Patent number: 7842310Abstract: A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35? and about 300?, and/or the powder comprises dried particles having an average mean diameter of between about 35? and about 300?. Compositions made by the above methods, and methods of using the compositions, are also described.Type: GrantFiled: November 19, 2002Date of Patent: November 30, 2010Assignee: Becton, Dickinson and CompanyInventors: Robin Hwang, Vincent Sullivan, Juan Huang, Zhaolin Wang, John A. Mikszta, David Montgomery, Brandi Ford, Anjana Bhuta-Wills
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Publication number: 20100000111Abstract: The present invention provides a method of measuring moisture content of an object for drying during drying in a drying chamber by, for example, freeze-drying, fluidized bed drying or shelf drying, in real-time and in a non-destructive manner. According to the present invention, when measuring moisture content of an object for drying, a near infrared absorption spectrum of moisture present around the object for drying is measured, and the moisture content of the object for drying is calculated from a predetermined relationship based on a measured amount obtained from the measured near infrared absorption spectrum.Type: ApplicationFiled: November 28, 2006Publication date: January 7, 2010Applicant: Eisai R&D Management Co., Ltd.Inventor: Tomohiko Takeuchi
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Patent number: 7640756Abstract: An integrated industrial plant includes various systems, all of which use a cryogenic liquid obtained from a common source. One system includes a fermentation unit, in which cold air, chilled by heat exchange with the cryogenic liquid, absorbs excess heat generated by the fermentation. Another system is a lyophilization unit, in which a refrigeration step is performed through the use of air that has been chilled by heat exchange with the cryogenic liquid. Another system is a device for freezing discrete samples of biological products, the samples being frozen by partial immersion in the cryogenic liquid. The invention substantially reduces the use of electric power, and provides systems which operate economically and reliably.Type: GrantFiled: March 30, 2006Date of Patent: January 5, 2010Assignee: American Air Liquide, Inc.Inventor: Sudhir R. Brahmbhatt
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Publication number: 20090260253Abstract: An membrane drying system comprising: a chamber, a vacuum pump, a sweep gas source, and a membrane device, wherein the membrane device comprises a membrane, a first inlet in fluid communication with the chamber and the membrane, a first outlet in fluid communication with the membrane and the vacuum pump, a second inlet in fluid communication with the sweep gas source and the membrane, and a second outlet in fluid communication with the membrane.Type: ApplicationFiled: April 17, 2009Publication date: October 22, 2009Inventors: Keith A. Roberts, Ryan Hoitink, Michael Spearman
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Publication number: 20090241364Abstract: A drying and freezing method without cooling medium comprises the steps of removing moisture, separating cold air from hot air and mixing the cold air with the hot air. Under the condition of no cooling medium, the above-mentioned steps separate the moisture from the compressed air, separate the cold air from the hot air and mix the cold air with the hot air. The system using the drying and freezing method without cooling medium comprises at least one air dryer having an air-moisture separation chamber for separating air from moisture and at least one separator having a separation chamber for separating cold air from hot air. The separator is connected to a pipeline to mix the cold air with the hot air.Type: ApplicationFiled: March 27, 2008Publication date: October 1, 2009Inventor: Jack LEE
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Publication number: 20080063493Abstract: The present invention is directed to a substrate dryer, a substrate treating apparatus including the substrate dryer, and a substrate treating method. The substrate dryer includes a chamber, a process chamber constituting one part of the chamber and provided for supplying supercritical fluid to a substrate to dry the substrate, and a high-pressure chamber constituting the other part of the chamber and provided for boosting the process chamber above a critical pressure. According to the present invention, the substrate drying chamber is boosted fast by the high-pressure chamber to change to a supercritical state and thus a substrate dry treatment is performed using supercritical fluid.Type: ApplicationFiled: May 31, 2007Publication date: March 13, 2008Inventors: Jung Keun Cho, Kyo-Woog Koo
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Patent number: 6783602Abstract: The present invention is directed to a method for controlled environment processing of parts in a chamber or chambers wherein solvents and/or solutions used for processing the parts can be introduced. The process includes applying a negative gauge pressure to the chamber to remove air or other non-condensable gases. Next a solvent, solvent mixture or solution in either a liquid or vapor state is introduced to the chamber. A first system is then applied to recover the solvent(s) or solution(s) from the object being processed and chamber, and a second system, separate from the first system, is applied that further recovers residual solvent or solution from the object and chamber. Treatment of the part may be in the form of coating, etching, deposition, cleaning, stripping, plating, adhesion, dissolving, penetrating, anodizing, impregnating, debinding or any other process in which material is removed or deposited on a solid surface by transfer from or to a liquid or gas phase.Type: GrantFiled: September 23, 2003Date of Patent: August 31, 2004Inventor: Donald Gray
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Patent number: 6684524Abstract: The invention relates to a lyophilization method which comprises the following steps: reducing the pressure in the drying chamber until the onset of a visible crystallization of the solvent at a temperature in the drying chamber which is above the solidification point of the preparation; reducing the temperature in the drying chamber to a temperature which is below the solidification point of the preparation or is identical to it, until completion of the crystallization of the solvent, resulting in a frozen solvent; and sublimation of the frozen solvent by means of reduced pressure.Type: GrantFiled: February 1, 2002Date of Patent: February 3, 2004Assignee: Bayer AktiengesellschaftInventors: Bernd Sennhenn, Martin Kramer
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Patent number: 6108934Abstract: A tanning hair dryer and/or hair steamer and process is disclosed wherein a user can receive light from an ultraviolet ray source while also receiving conditioned air from a hair dryer and/or hair steamer. The invention can either be manufactured or applied to existing hair dryers and/or hair steamer hoods by retrofitting. Two embodiments of the invention are disclosed. In the first embodiment, a tanning shield is attached to a hood by two pivotally attached attaching arms. In the second embodiment, two tanning shields are attached to the hood by universal positioning means, or means that enable the tanning shields to be placed in a number of different positions with a number of different orientations.Type: GrantFiled: March 16, 1999Date of Patent: August 29, 2000Inventor: Miljko Todorovic
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Patent number: 5843506Abstract: The present invention provides a new ice nucleus-forming bacterium strain, Xanthomonas campestris INXC-1 (FERM BP-4191), a process for the cultivation of the new ice nucleus-forming bacterium, an ice nucleus-forming substance containing the ice nucleus-forming bacterium, and the uses of the ice nucleus-forming substance. Further, a method for lyophilizing a food using the strain as an ice nucleus-forming substance is disclosed; wherein the method is carried out by adding the strain to the food, thereby freezing the food, and then vaporizing moisture from the frozen food to effect drying. The food types which may be lyophilized using the method include tea extracts, fruit juices, soy sauce, sauces, drippings, soups fermented soy bean paste and agar.Type: GrantFiled: June 23, 1997Date of Patent: December 1, 1998Assignee: Q.P. CorporationInventors: Michiko Watanabe, Takahiro Makino, Kazuo Honma
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Patent number: 5522155Abstract: The present invention relates to a lyophilization process involving the use of a cap intended for vials or use therewith for containers that are subjected to lyophilization conditions where the cap, which may be resiliently helped in place or screwed on, includes a plug member movable within a fluid passageway in the cap, the plug member while positioned in the fluid passageway is movable between a first upwardly extending venting position and second downwardly engaging, sealing position whereby fluid from the vial or container is precluded from flowing through the fluid passageway in the cap.Type: GrantFiled: April 7, 1995Date of Patent: June 4, 1996Assignee: W. L. Gore & Associates, Inc.Inventor: C. Bradford Jones